LOCUS       NZ_CP114205            10216 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces tubercidicus strain DSM 40261 chromosome, complete
            genome.
ACCESSION   NZ_CP114205
VERSION     NZ_CP114205.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tubercidicus
  ORGANISM  Streptomyces tubercidicus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8284047)
  AUTHORS   Ruckert,C., Busche,T., Kalinowski,J. and Wittmann,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2022) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-MAR-2022
            Assembly Method                   :: flye v. 2.9; Newbler v. 2.8
            Assembly Name                     :: DSM40261_v1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 133.7x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/09/2024 02:53:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,167
            CDSs (total)                      :: 7,077
            Genes (coding)                    :: 6,906
            CDSs (with protein)               :: 6,906
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 171
            CDSs (without protein)            :: 171
            Pseudo Genes (ambiguous residues) :: 0 of 171
            Pseudo Genes (frameshifted)       :: 72 of 171
            Pseudo Genes (incomplete)         :: 133 of 171
            Pseudo Genes (internal stop)      :: 9 of 171
            Pseudo Genes (multiple problems)  :: 41 of 171
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:04:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7461106
            Orig. end                         :: 7471322
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP114205.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from DSM 40261.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="30"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    70..83
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            602..1510
                     /db_xref="GeneID:96287413"
                     /locus_tag="STRTU_RS32705"
                     /old_locus_tag="STRTU_006542"
     CDS             602..1510
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96287413"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091736.1"
                     /locus_tag="STRTU_RS32705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_006542"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_159748695.1"
                     /transl_table=11
                     /translation="MIEARRLHILRAVADHRTVTAAAAALYLTPSAVSQQLAALEQETG
                     HRLVERSARGVRLTAAGDILLTHANAVLAQLERAESELAAYGSGEAGTVTVAAFATGIG
                     LVVAPALTALARTAPGIRVRVQDAEGDASLLMVLDRQVDVAVAVEYRGAPGADDPRLTR
                     VPLYAEPFDAVLPPGHRLAETPQVALAELAGDPWIGPYPGNPCHDVVVLACEYAGFQPR
                     LEHTSDDFRAVVALASAAAGVALVPRSALRDMDLTGVVVRPVDEVAPTRRVFAAVRRGA
                     EEHPLFRPVLAALREAAASQG"
     misc_feature    621..637
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            1670..3028
                     /db_xref="GeneID:96287414"
                     /locus_tag="STRTU_RS32710"
                     /old_locus_tag="STRTU_006543"
     CDS             1670..3028
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96287414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091737.1"
                     /locus_tag="STRTU_RS32710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_006543"
                     /product="chloride channel protein"
                     /protein_id="WP_159748696.1"
                     /transl_table=11
                     /translation="MSVGPAGPVGEAPTTVPQDPYALVRTRGYLKLLLVAAAIGFPVCA
                     VAFGFLALVHELEPLIYQDLPRALGFAGTPLWWPVPMLLVAGLLVGLTVRYLPGGGGHE
                     PADGLALHGAPPLSALPGVVLAALASLSFGAVVGPEAPLIALGGGLAAGAVRLVDRGAP
                     AQTVATVGAAGSFAAISALLGSPLLGAFLLMEVSGLGGPMLGIVLVPGLLASGLGALIF
                     TGLGDWTGLGTYSLTLHDIPAASAPTIAEFGWALVIGLAAGFAATGVGRLARFLKGHVA
                     RHRVPATMVMGLVVGALAVAFAASTGKPASEMLYSGQSALGSLFRDSAGYTVGALLLLL
                     LCKGLAYCASLSAFRGGPIFPALFLGAAGGVALSHLPGLSLTAGFAMGVGAMCVAMLRL
                     PMTSVLLATLLLGKSGLTVMPLVIVAVVVAYVVALRLTPAPAPDAPAPAPHPA"
     gene            complement(3152..4183)
                     /db_xref="GeneID:96287415"
                     /locus_tag="STRTU_RS32715"
                     /old_locus_tag="STRTU_006544"
     CDS             complement(3152..4183)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96287415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389366.1"
                     /locus_tag="STRTU_RS32715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_006544"
                     /product="PHP domain-containing protein"
                     /protein_id="WP_159748697.1"
                     /transl_table=11
                     /translation="MEPVEALERIAFLLERQGAVTYRVQAFRTAATVIGALPADELRSR
                     AGSGSLARLKGLGPKTTRVIEEALAGARPAYLTHLEEEAGGPLVEGDQGQRMRQALRGD
                     CHLHSDWSDGGSPVEAMARAARDLGHSWCVLTDHSPRLTVARGLTAERLRQQLSLVAEV
                     NERLAPFRLLTGIECDILDDGSLDQEPELLEQLDVVVASVHSKLRMDKAPMTRRLLAAV
                     RNPLVDVLGHCTGRQITGKRRPESQFDADEVFAACAEHHTAVEINCRPDRLDPPRRLLR
                     QALETGTLFSIDSDAHAPGQLDWQIYGCARAEECGVPPERVINTWTERQLATWTRTGRT
                     PHG"
     misc_feature    4583..4599
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.17"
                     /tool="antismash"
     gene            5001..5216
                     /db_xref="GeneID:96287416"
                     /locus_tag="STRTU_RS32720"
                     /old_locus_tag="STRTU_006545"
     CDS             5001..5216
                     /codon_start=1
                     /db_xref="GeneID:96287416"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="STRTU_RS32720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_006545"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_159748698.1"
                     /sec_met_domain="strepbact (E-value: 8.4e-27, bitscore:
                     92.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVQTQEISDSDLDNVSGGLVGGVLGAADSIAPVSGAVGTA
                     TGLVDGVAGTDTTGVVGTATGLVSGL"
     misc_feature    complement(5258..5270)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            5395..6204
                     /db_xref="GeneID:96287417"
                     /locus_tag="STRTU_RS32725"
                     /old_locus_tag="STRTU_006546"
     CDS             5395..6204
                     /codon_start=1
                     /db_xref="GeneID:96287417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="STRTU_RS32725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_006546"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_159748699.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEEIDLPVRFARPQGWLVLTVTVLFVIAASVW
                     AVTGTVSSTLNAPGILTHGQGSYILQSPVAGQVTAVLAEEGKRVPAHTPVLRVRTAQGT
                     TTVVRTLAAGRLTTMVATIGSVVTTGADVASVERIAKASDPLTATLYVPAQNGATVPVG
                     AAVDLTVQSVPTQQYGVLRGRVKAVGRTAQSRQRIGTYLGSSQLGEEFSQHGQPIAVLV
                     ELDAAPHSKSGYAWSTSGGPPYTVDSMTPASGAVHLAAQHPIDWLLP"
     gene            6201..8486
                     /db_xref="GeneID:96287418"
                     /locus_tag="STRTU_RS32730"
                     /old_locus_tag="STRTU_006547"
     CDS             6201..8486
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96287418"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091742.1"
                     /locus_tag="STRTU_RS32730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_006547"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_159748700.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.9e-37, bitscore:
                     126.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHDSAAPQQQLPPPVRGRRRSETAPGARRARRAAPAPKPKKT
                     KTVRTPTVLQMEAVECGAASLAMVLAHYGRHVPLEELRIACGVSRDGSRASNLLKAARS
                     YGLQAKGMQMEPAALAEVQGPAILFWEFNHYVVYDGMGRRLGRRGVHINDPDKGRRFVA
                     MEDFDTSFTGVALVLEPGESFHKGGRKPGVLSAVPARMRGTTGTLLAALLASLLLVAVG
                     AAVPALSRTYIDMFLIGNQTSLLGPLFASMAAMVGLTAVLTGLQQANLLRGRIISSTLT
                     SARFLRHLLRLPVTFFAQRSPADLVQRLQSNDAVAETLARDLAAAGVDGIVVILYAFLL
                     WTYDPQLTVIGVGIALLNVVAMRIVVRLRATHTQKLRADTARLTNTSYTGLQLIETMKA
                     TGGENGYFRRWAGQHATTLEEQQRLGVPSAALAVVAPTLATFNSALILWIGGLRAVEGH
                     ISIGLLVAFQALVTRFTAPITRLNGVAGRIQDFAADVARLKDVESFPVDTLYSRPEPDA
                     DTRRLKGHVTLEDITFGYSPLDKPLLTGFSLAVGPGRQVALVGGSGSGKSTVSRLISGL
                     YSPWEGTIRIDGQRLEDLSRSALAASVSFVDQDIFLFEGTVRDNVALWDPSIPDDAVIT
                     ALQDAGLYDEVIAPRPDGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSA
                     LDARTEQIIMDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGVVVERGRHEDLVAAGGP
                     YAELVKEH"
     misc_feature    9848..9862
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     misc_feature    complement(9876..9885)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 tcgacgactc gcacgcggtc ggcttcgtcg gccccggcgg ccgcggcacc cccgagctgc
       61 acggcgtgat ggaccgggtc gacatcatca ccggcaccct cggcaaggcc ctcggcggtg
      121 cctccggcgg ctatgtcgcg gcccgcgccg agatcgtcgc cctgctgcgc cagcgctcgc
      181 gcccgtacct cttctccaac tcgctcgccc cggtgatcgc ggccgcctcg ctgaaggtgc
      241 tcgacctgct ggagtcggcc ggtgacctgc gcgagcggct caacgccaac accgcgctgt
      301 tccgctcgcg gatgaccgag gagggcttcg acatcctccc cggcgaccac gccatcgccc
      361 ccgtcatgat cggtgacgcg gccgaggcgg cccggatggc ggagctgctc ctggagcgcg
      421 gcgtctacgt catcggcttc tcctaccccg tggtgccgca gggccaggcg cggatccgcg
      481 tccagctgtc cgccgcccac tccaccgagg acgtcaaccg cgcggtcgac gccttcgtcg
      541 cagccagggc cgcgctcgcg ggctgacacc gcccgctctc cggtcctgcg agactgggag
      601 catgatcgaa gcacgacggc tgcacatcct ccgtgcggtg gccgaccacc gcacggtcac
      661 cgccgcggcc gccgcgctct atctcacgcc ctcggcggtc tcccagcagc tggccgccct
      721 ggaacaggag accggccacc gactggtgga gcgcagcgcc cgcggcgtac ggctgaccgc
      781 cgcgggcgac atcctgctca cccacgccaa cgccgtcctg gcacagctgg agcgcgccga
      841 gtccgagctc gccgcctacg gttcgggaga ggcgggcacg gtgaccgtcg ccgccttcgc
      901 caccggcatc ggcctggtcg tcgcgcccgc cctcaccgcg ctggcccgta cggcccccgg
      961 catccgggtc cgtgtccagg acgccgaggg cgacgccagt ctgctgatgg tcctcgaccg
     1021 gcaggtcgat gtggcggtgg ccgtcgaata ccggggcgcc ccgggcgccg acgacccacg
     1081 gctgacccgg gtcccgctct acgccgagcc gttcgacgcg gtgctgccgc ccggtcaccg
     1141 cctcgccgag acgccccagg tggccctggc cgagctcgcc ggcgacccct ggatcggccc
     1201 ctaccccggc aatccctgcc atgacgtggt ggtcctggcc tgcgaatacg ccggtttcca
     1261 gccgcgtctg gagcatacgt ccgacgactt ccgcgccgtg gtcgcactcg cctcggccgc
     1321 ggcgggcgtg gcgctcgtcc cccgctcggc gctgcgcgat atggacctca cgggggtggt
     1381 ggtccgcccc gtcgacgagg tggctcccac ccgccgggtc ttcgccgcgg tacgccgtgg
     1441 cgcggaggag cacccgctgt tccgcccggt gcttgccgcc cttcgggagg cggcggcgtc
     1501 gcaggggtga gggcgtcgcg gagacggcgg caaccgctgt gagcatcaca gcgacggtgc
     1561 cccgcccggc cgcttccgaa gtgcccgccc cgccccgcca tggcaggctc atcacggcgg
     1621 cggcccggtc gggctccggg gcagccccgg ttccgaggag gcgaggcgca tgtcggtcgg
     1681 cccggccggc ccggtgggcg aagcgccgac caccgtgccc caggacccct acgcgctggt
     1741 gcgcacccgc ggctatctga agctgctgct ggtggcggcg gccatcggct tcccggtctg
     1801 cgccgtcgcg ttcggctttc tcgcgctggt ccacgagctg gaaccgctca tctaccagga
     1861 cctgccgcgg gcgctgggct tcgccgggac gcccctctgg tggccggtcc cgatgctgct
     1921 ggtggccggt ctcctcgtcg ggctgaccgt ccgttatctg cccggcggcg ggggccatga
     1981 gccggccgac gggctggcgc tccacggtgc gcccccgctc tccgcgctcc ccggtgtcgt
     2041 ccttgccgcc ctggcctccc tcagcttcgg cgcggtggtc ggccccgagg cgccgctgat
     2101 cgcgctcggc ggcggtctgg ccgcgggcgc cgtacggctg gtggaccgtg gcgcgccggc
     2161 tcagacggtc gccacggtgg gcgcggccgg cagcttcgcg gcgatcagcg cgctgctcgg
     2221 ctccccgctg ctgggggctt tcctgctgat ggaggtgtcg gggctgggcg gtccgatgct
     2281 gggaatcgtc ctggtgcctg gcctgttggc gtccggcctg ggggcgctga tcttcaccgg
     2341 gctgggggac tggaccgggc tcggtacgta ctcgctcacg ctgcacgaca tccccgcggc
     2401 ctccgcgccc acgatcgcgg agttcggctg ggccctggtc atcgggctgg ccgccgggtt
     2461 cgccgcgacc ggggtagggc gcctcgcgcg gttcctcaag gggcatgtcg cccggcaccg
     2521 ggtaccggcc acgatggtga tgggtctcgt ggtgggcgca ctggcggtgg cgttcgccgc
     2581 gtccaccggc aagcccgcct ccgagatgct ctattcgggc cagtcggcgc tgggttcgct
     2641 gttccgggac agcgccggtt acacggtggg tgcgctgctg ctcctcctcc tgtgcaaggg
     2701 cctggcgtac tgcgcctcgc tgagcgcctt ccggggcggc ccgatcttcc cggcgctgtt
     2761 cctgggcgcg gcgggcggtg tggcgctgtc ccacctgccc ggtctgtcgc tcaccgcggg
     2821 cttcgcgatg ggcgtcggcg cgatgtgtgt ggcgatgctc cggctgccga tgacgtcggt
     2881 gctgctggcc acgctgctgc tggggaagag cggtctgacg gtgatgccgc tcgtgatcgt
     2941 cgccgtggtt gtcgcctacg tcgtggcgct gcgcctcacc cctgcccccg caccggacgc
     3001 cccggccccc gcacctcacc ccgcctgacg acgtgtgggt tccgcctcgc gcggtccctc
     3061 tgccgccggg gcggtgcgcg gcgtccggcg ggagggcggg aattacgaac ccctaccggc
     3121 ccctaccggc cccgaccggc cccgcccgcg ctcagccgtg cggggtccgg cccgtccgcg
     3181 tccaggtggc caactggcgc tccgtccagg tgttgatgac ccgctccggt ggtacgccgc
     3241 actcctcggc gcgggcgcag ccgtagatct gccagtccag ttggccgggt gcgtgggcgt
     3301 cgctgtcgat ggagaagagg gtgccggtct ccagcgcctg gcggagcagt cggcgtgggg
     3361 ggtcgaggcg gtcggggcgg cagttgatct ccaccgcggt gtggtgctcg gcgcaggccg
     3421 cgaacacctc gtcggcgtcg aactgcgact ccgggcgccg tttgccggtg atctgccgcc
     3481 cggtgcagtg gccgagcaca tccaccagcg gattacggac cgcggccagc agccgccggg
     3541 tcatcggcgc cttgtccatc cgcagtttgg agtgcaccga ggcgaccacc acatcgagct
     3601 gctccagcag ctccggctcc tggtcgagtg agccgtcgtc gaggatgtcg cactcgatcc
     3661 cggtcagcag ccggaacggt gccagccgct cgttcacctc cgccaccagc gacaactgct
     3721 gccgcagccg ctcggcggtc agtccacggg cgacggtgag ccggggggag tggtcggtca
     3781 gcacacacca gctgtgtccg aggtcgcggg cggcccgtgc catcgcctcg accggactgc
     3841 cgccgtccga ccagtccgag tgcagatggc agtcgccgcg cagcgcctga cgcatccgct
     3901 gcccctggtc gccctcgacg agcgggccgc ccgcctcctc ctcaaggtgt gtcagatacg
     3961 cgggccgcgc gcccgccaga gcctcctcga tcacccgggt ggttttgggg ccgagccctt
     4021 tgaggcgcgc cagcgagccg cttccggcac gggagcgcag ttcgtcggcg gggagtgcgc
     4081 cgatcaccgt cgcggccgta cggaacgcct ggacgcggta ggtcaccgct ccctgccgct
     4141 ccagcagaaa ggcgatccgc tccagcgcct ccacgggctc cacgtacggc tccttcccgg
     4201 ggcgcccgcc ccgcagcgtc catctcacgg tgcctcacct ggtgggcggc tgccaccggg
     4261 tggggcaccg gggcggccgc ggcagccggt acggccggtg cggtggtgcg accggcgcgg
     4321 tggtgccaat cgcccattac cgacgcatcc gaaggtgctc cgttatgcgg ttatgtccgt
     4381 tgtccgctca ctcgatccgt tcctgatccg tttccgcaga aatggcatac ggatagcgcc
     4441 gatgagtcca ttccatatgt tccgcaccgc agatatcgct gatgaactcc gggcgaatcg
     4501 ggcgcactta atgcccttgt cgcattcggc cgggctctgt cggaagtgtg tgtcggagtt
     4561 gtctgtccgt atcgcgccga ggtgccgtaa aaattggcgg ccttcaagga atctgcacac
     4621 cgaatgtgca gtcggtacac gccccaccgg gtcgcatccc cacgctgacc tgcggcaaag
     4681 cggtttggtg agggaatgtc cagttcgccg atcgggtgct tgccggggtt ccggaaaaga
     4741 aaccggagga gatgtgaaga agctgccacc aagtcatgga cgggcgtgca cgtcaggtat
     4801 ttcgaggggg tgatgacgcc cggatctgcg gctgtccgat tcgcagtgca acgcacctgc
     4861 gtgctttgat ccttcgcact gcgggagtca ccccccggtt cccgatatcg ggaaccccga
     4921 ctgccgctgc cgcggccggg ccactccacc ggacggttcg gtcgcagctt tttcgagata
     4981 ttcatccgaa gggaatcatc atgaactcca ccccccaggt tcagacgcag gaaatctccg
     5041 acagcgacct ggacaacgtg tccggtggcc tcgtgggtgg cgtgctcggc gccgctgaca
     5101 gcattgcccc ggtctcgggc gccgtgggca ccgccaccgg cctggtcgac ggtgtcgccg
     5161 gcaccgacac cacgggcgtc gtcggcaccg ccacgggcct ggtctccggt ctctgagccc
     5221 cttctgtgcc actgagcggc acagccggct ttgaacggtg acaacggcag gtcggcgccc
     5281 cctccttgcc gacatgccgg gccggctgcc ccggtccgcc cggactccat ccgggcccgg
     5341 ggcaccggcc accacctgtc cgaacgagaa cgttgcagtt gagggaagag tgtcgtgcag
     5401 ttccgccaac aggccctttc caagctgcag tcgcccgagg aaatcgatct tccggtccgg
     5461 ttcgcccggc cccagggctg gctcgtcctg accgtcacgg tcctctttgt gatcgccgcc
     5521 tccgtatggg cggtgaccgg caccgtgtcc tccaccctga acgcacccgg aatcctcacg
     5581 cacggccagg gcagctacat cctgcagagc cccgtcgcgg gccaggtcac cgccgtcctc
     5641 gcggaagagg gcaagcgggt gcccgcccac acgcccgtcc tgagggtccg taccgcccag
     5701 ggcaccacca ccgtcgtccg tacgctcgcc gccggccggc tgaccacgat ggtcgccacc
     5761 atcggctccg tcgtcacgac cggcgcggac gtggcctccg tggaacgcat cgcgaaggcc
     5821 agcgaccccc tgacggcgac gctgtacgta ccggcccaga acggcgccac cgtccccgtc
     5881 ggcgccgccg tcgacctcac cgtccagtcc gtgccgacgc agcagtacgg cgtgctgcgc
     5941 gggcgggtca aagcggtcgg caggaccgca cagagccgcc agcggatcgg cacctacctg
     6001 ggcagcagcc agctcggcga ggagttctcg cagcatggcc agcccatcgc ggtcctggta
     6061 gagctcgacg ccgccccgca cagtaagtcc ggctacgcct ggtcgacctc cggcggcccc
     6121 ccgtacaccg tcgactccat gacgccggcc agtggcgccg tccacctggc cgcgcagcac
     6181 ccgatcgatt ggctgctgcc gtgaccgccc cccacgactc cgccgccccg cagcagcagt
     6241 tgccgccgcc ggtccgcggc cgccgccgct cggaaaccgc gcccggcgcc cgccgcgccc
     6301 gccgtgccgc gcccgccccg aagcccaaga agacgaagac cgtccgcacc cccaccgtcc
     6361 tccagatgga ggccgtggaa tgcggcgccg cctcgctggc catggtgctg gcccactacg
     6421 gacggcacgt cccgctcgaa gagctgcgga tcgcctgcgg cgtctcccgc gacggctcgc
     6481 gcgccagcaa tctgctcaag gcggcccgca gctacggcct ccaggccaag ggcatgcaga
     6541 tggaaccggc cgcgctcgcc gaggtgcagg gccccgcgat cctgttctgg gagttcaacc
     6601 actacgtcgt ctacgacggt atgggccggc gcctcggccg ccgcggcgtg cacatcaacg
     6661 accccgacaa gggccgccgc ttcgtggcga tggaggactt cgacaccagc ttcaccggcg
     6721 tcgccctggt cctcgaaccc ggcgagtcct tccacaaggg cggccgcaag cccggcgtgc
     6781 tgagcgccgt gcccgcccgg atgcgcggca cgaccggcac cctgctggcc gcgctgctcg
     6841 ccagcctgct gctggtcgcg gtcggcgccg cggtgcccgc gctcagccgt acgtacatcg
     6901 atatgttcct gatcggcaac cagacctctc tgctggggcc gctcttcgcg tcgatggccg
     6961 ccatggtcgg gctgaccgcc gtactgaccg gtctgcaaca ggccaatctg ctgcgcggcc
     7021 ggatcatctc ctccaccctc accagcgccc gcttcctgcg ccatctgctc agactcccgg
     7081 tcaccttctt cgcccagcgc agcccggccg acctggtcca gcggctgcag tccaacgacg
     7141 cggtcgccga gaccctggcc cgtgacctcg ccgccgcggg cgtggacggg atcgtcgtca
     7201 tcctctacgc gttcctgctg tggacctacg acccccaact gaccgtcatc ggcgtgggga
     7261 tcgcactgct caatgtcgtc gccatgcgga tcgtggtccg gctgcgggcc acccacaccc
     7321 agaagctgcg cgccgacacc gcacggctga ccaacacctc ctacaccggc ctccagctca
     7381 tcgagacgat gaaggccacc ggcggggaga acggctactt ccgccgctgg gccgggcagc
     7441 acgccaccac gctggaggaa cagcagcggc tgggtgtgcc gagcgccgcg ctggccgtcg
     7501 tcgcgcccac cctggccacg ttcaacagcg cgctgatcct gtggatcggc ggactgcggg
     7561 ccgtcgaggg ccatatctcc atcggactgc tggtcgcctt ccaggcgctg gtgacccgct
     7621 tcaccgcgcc catcacccgg ctcaacggag tggccggccg catccaggac ttcgccgccg
     7681 atgtggcccg cctcaaggac gtcgagagct tccccgtcga caccctctac tcgcgccccg
     7741 agccggacgc cgacacccgc cgcctcaagg gccatgtgac gctggaggac atcaccttcg
     7801 gctacagccc gctggacaaa ccgctgctga ccggcttctc gctggccgtc ggccccggcc
     7861 ggcaggtcgc cctggtcggc ggctccggca gcggcaagtc caccgtctcc cggctgatct
     7921 ccggcctcta cagcccctgg gaaggcacca tccgcatcga cgggcagcgg ctggaggacc
     7981 tctcgcgcag tgcgctggcc gcctccgtgt ccttcgtcga ccaggacatc ttcctcttcg
     8041 agggcacggt ccgggacaac gtcgcgctgt gggacccgtc catcccggac gacgcggtga
     8101 tcaccgccct ccaggacgcc gggctctacg acgaggtgat cgccccccgc cccgacggca
     8161 tccacagccg ggtcgagcag gacggccgta acttctccgg cgggcagcgg cagcggctgg
     8221 agatcgcccg cgccctcgtc cggcgcccca gcatcctggt cctcgacgag gtcaccagcg
     8281 cgctggacgc ccggaccgaa cagatcatca tggacaacct gcggcggcgc ggctgcgcct
     8341 gcgtcgtcat cgcccaccgg ctgagcacgg tccgcgacag cgacgagatc gtcgtcctcg
     8401 accacggagt ggtcgtcgaa cgcggccggc acgaggacct ggtcgccgcc gggggcccgt
     8461 acgccgagct ggtcaaggag cactgacgtg tccgtacccc cgtccacggt cgtgggaccg
     8521 ggcgacaccg atgccgtgac gtacgcactg ggcggcctcg gcacaccggt cgactgcacc
     8581 gggctgcgca gcgtccccct ggagggcccg catgtgctgt ggctcgtcac aggcggctcg
     8641 ctggacctct tcgcggtcga cgccgcccag gaagggcact ggcacttcct cggccgcctg
     8701 gaagcaggca ccctgctgct cggcccggtc gcgggcccgc agcacaccct gctcggccgg
     8761 ccctcccagg actgcctgct gcgccgcctc ccgctgcgcg agctgccccg gtacgagtac
     8821 ggggagtacg gcgacaccgg gtcgttcccg cagtacggca cgcaggacgg ctacggccac
     8881 gacgccgcgt acggagccca ggcccaggcg ccctccgcac tggagcacgc cttcgcgctg
     8941 ggcaccgccc gcagcctggg cgtgctcttc gaggcaccgc tcgacggccg gcccggcgat
     9001 gacgcggtgg ccgacgacga catcctgtgg atgccggtcc cgcccggcag tgtgcagtac
     9061 ggcgcctcct acagcgcgga ggcggccggc gatctgctgg tggaccccga gctgtggcag
     9121 cagatggtca atcagcagta ccggctgctg tccgccgtcg accgctggat cgagcagctg
     9181 gagcgcgccc acgaggaccg tacggcggcc ggtatcaagg cgggcgaaac cgttcgcgag
     9241 cgcgccgacc aggcgctggt ggcatccatc ggccgggccg ggcggggcgg tgccacgacg
     9301 gaccggaccg gcgatgacac caccttcgcg gtctgccgca cggtcgcgga ggcggccggt
     9361 atcacgctca ccgagccgcc gaagggcggc gccgtcaacg accggatcac cccggtcgaa
     9421 cggatcgcgg tcagctcgcg gatccggacc cgggcggtcc ggctccaggg accctggtgg
     9481 cggaccaaca ccgggcccct ggtgggccat cgcgccaagt ccggtgcccc ggtggcgctg
     9541 ctgtggcgcc gtggccggta cgaggcggtc aacccggtct ccggtctgcg gatgcgcctc
     9601 ggcaaggaca acgccgggga actcgaaccg cgcgccgtca tgttctaccg cccgctgccg
     9661 gagcggccca tgagcctgtg gcggctgatg ctcttcagcc tgcgcggcac ccgtatggac
     9721 ctgcgcaatc tggctctcag cggactggtg accgtcggcc tcggcgccct cgtcccgctc
     9781 gccaccggca aggtgctcgg ggagtacgta ccgagcgcgg acaagagcct gatcgtgcag
     9841 gtctccctgg ccgtcatggt caccagcgtg gtctcggccg ccttcatgct gatgcagaac
     9901 ctcaccgtcc tgcggatgga gggccgcatc gagagcgccc tccagccggc cgtatgggac
     9961 cggctgctgc ggctgccgac gaagttcttc accgaacgct ccaccggaga gctggccagc
    10021 gccgcgatgg gcatcagcag catccgccgg gtgctgtccg gcctcggccc ggtggccgtg
    10081 cagtccacca ccgtcggcgc gatgaatctg gtgctgctgc tctgcttcag cgtgccgctg
    10141 gcgctggccg cgatcgccat gctgctcgtc atcggcgcgg tgttcctcgg catgggcctg
    10201 tgggaactgc gctggc
//
