LOCUS       NZ_CP114205            24586 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces tubercidicus strain DSM 40261 chromosome, complete
            genome.
ACCESSION   NZ_CP114205
VERSION     NZ_CP114205.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tubercidicus
  ORGANISM  Streptomyces tubercidicus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8284047)
  AUTHORS   Ruckert,C., Busche,T., Kalinowski,J. and Wittmann,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2022) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-MAR-2022
            Assembly Method                   :: flye v. 2.9; Newbler v. 2.8
            Assembly Name                     :: DSM40261_v1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 133.7x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/09/2024 02:53:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,167
            CDSs (total)                      :: 7,077
            Genes (coding)                    :: 6,906
            CDSs (with protein)               :: 6,906
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 171
            CDSs (without protein)            :: 171
            Pseudo Genes (ambiguous residues) :: 0 of 171
            Pseudo Genes (frameshifted)       :: 72 of 171
            Pseudo Genes (incomplete)         :: 133 of 171
            Pseudo Genes (internal stop)      :: 9 of 171
            Pseudo Genes (multiple problems)  :: 41 of 171
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:04:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 693020
            Orig. end                         :: 717606
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP114205.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from DSM 40261.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24586
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="7"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24586
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24586
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14586](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14586
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            569..1456
                     /db_xref="GeneID:96281524"
                     /locus_tag="STRTU_RS03140"
                     /old_locus_tag="STRTU_000628"
     CDS             569..1456
                     /codon_start=1
                     /db_xref="GeneID:96281524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543160.1"
                     /locus_tag="STRTU_RS03140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000628"
                     /product="phenylalanine 4-monooxygenase"
                     /protein_id="WP_159742123.1"
                     /transl_table=11
                     /translation="MSTAWQYTPISADGRLGLADQHPGRSDPAYRRRRDALAARAEGHR
                     VGAPYPAVDYTEDEHRTWRAVHRALGPAHHAHACRAVLDAGEDAGIRADRIPQHTEVSA
                     LLTARTGFAFTLAGGVVPNERFLGAMAHGYFHAVQFVRHPAVPLYAPEPDVLHDVFGHG
                     VHLSCARLARLYRLIGQAANRTETDEALATLSRVYWFTLEYGLITEAGTPKAFGAALLS
                     SYGEIGAHDRRTIHPLDLRAAATTPYLISGYQPVLYAARSLEHLEDVLGAFCTDFDDDS
                     ASRLCVPALPRDRP"
     gene            complement(1485..2465)
                     /db_xref="GeneID:96281525"
                     /locus_tag="STRTU_RS03145"
                     /old_locus_tag="STRTU_000629"
     CDS             complement(1485..2465)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (51-219). E-value: 3.4e-15.
                     Score: 48.3. Matches aSDomain:
                     nrpspksdomains_STRTU_RS03145_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GeneID:96281525"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540479.1"
                     /locus_tag="STRTU_RS03145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000629"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_308789354.1"
                     /sec_met_domain="adh_short (E-value: 5.3e-33, bitscore:
                     113.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPMVCVHALNCAALHQVLQHARHQLGTAERFAMSSHPTHSSQASH
                     TSHPSKVVLITGTSSGIGLAAAVAAARAGWQVVATLRDTGRAGALRKAAEEAGVELDVR
                     QLDVTDERSVATAVDGVIADYGRLDAVINNAGAGHLGTLENESVAGVRTVMEVNFFGVL
                     HVSKAALPHLRATGGRLITVTSVGGVIGQPFNEAYCAAKFAVEGYMESLAPVAARLGVT
                     VSVVEPGAVATEFVNNIGVDLADEVAAAGPYADALQAYLDRTVAQFHGSAQTPDEAAVA
                     VLEALTADRPAFRLQTSDWARQFTGTKLTDLDGSAVLGLTSGWIG"
     aSDomain        complement(1809..2312)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRTU_RS03145_PKS_KR.1"
                     /evalue="3.40E-15"
                     /label="STRTU_RS03145_PKS_KR.1"
                     /locus_tag="STRTU_RS03145"
                     /protein_end="219"
                     /protein_start="51"
                     /score="48.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGTSSGIGLAAAVAAARAGWQVVATLRDTGRAGALRKAAEE
                     AGVELDVRQLDVTDERSVATAVDGVIADYGRLDAVINNAGAGHLGTLENESVAGVRTVM
                     EVNFFGVLHVSKAALPHLRATGGRLITVTSVGGVIGQPFNEAYCAAKFAVEGYMESLAP
                     VAARL"
     gene            2501..2962
                     /db_xref="GeneID:96281526"
                     /locus_tag="STRTU_RS03150"
                     /old_locus_tag="STRTU_000630"
     CDS             2501..2962
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281526"
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945613.1"
                     /locus_tag="STRTU_RS03150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000630"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_159742125.1"
                     /transl_table=11
                     /translation="MAKRKLTQAEMPVADHAFYGLVWAGTVLTERVDRALSKAHDLPVS
                     WFEVMLWLASSPDPVPASVLGNSTMLSRSQVSRVVDALQSRGLATRTPSARDARSVEVS
                     LTPDGHRLFDEADATRRACLAPVFTDLLDQEDLEALSTVWRKLKANKEG"
     misc_feature    complement(2505..2519)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            3094..4263
                     /db_xref="GeneID:96281527"
                     /locus_tag="STRTU_RS03155"
                     /old_locus_tag="STRTU_000631"
     CDS             3094..4263
                     /codon_start=1
                     /db_xref="GeneID:96281527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389355.1"
                     /locus_tag="STRTU_RS03155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000631"
                     /product="lactate 2-monooxygenase"
                     /protein_id="WP_159742126.1"
                     /transl_table=11
                     /translation="MAKHWADFQYEIYLHGMTGTVPRLPTDLTRLEQLAEQRLGPGPVG
                     YVAGSAGTGSTAAANRAALDRRRIVPRMLRDVHERDLSVELWGRALPAPLALAPVGVLS
                     IMHPDAESAAARAAAAHGVPYILSSASSTPMEQVAETMGDGERWFQLYWAKDREVTRSF
                     LNRAKAAGYTALFVTLDTPLLAWRPRDLDQAYLPFLHGVGTANYFSDPAFRAGLAKPVH
                     EDPNAAVRHFVGMFADPAKTWPDLAFLRENWDGPIVLKGVLHPDDALRAAEAGVDGVVV
                     SNHGGRQVAGSVAAADALPRVAEAAAGRLTVLFDSGIRTGDDIVKALALGAESVLVGRP
                     YAYGLGLDGQAGVEHVLRCLLAEFDLTLALSGHSRPAGLTADDLIEESV"
     misc_feature    complement(3104..3122)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.3"
                     /tool="antismash"
     gene            4260..5273
                     /db_xref="GeneID:96281528"
                     /locus_tag="STRTU_RS03160"
                     /old_locus_tag="STRTU_000632"
     CDS             4260..5273
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281528"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088668.1"
                     /locus_tag="STRTU_RS03160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000632"
                     /product="2-hydroxyacid dehydrogenase"
                     /protein_id="WP_159742127.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.2e-59, bitscore:
                     199.3, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPHSAPTPERHPVKNVLAVVSPHVGGRSAGAALAGLFPAQAR
                     VTVVESADEDPAALREAHLLITGLSPVTAAHLAAAPHLELVQCASHGFDYVDLDAARER
                     GIPVCNIGSSGAEKQNVAEQTFALMLALAKQLVPAHTALVEADWALPRLQQSLTELSGK
                     TLGIIGLGHIGKEVARRAVAFDMTVVYTGPRPAGPETEARLGGARYLSLNDLLRTSDYL
                     TLHAPLTDRTRNLLDAERLALLKPTAFVINTARGALIDQDALADALEAGTLAGAGLDVF
                     DPEPPTPALRLLKAPNVVLSPHVAGVTRETLVRIALAAVQNVIGHLEGKPLRDIVS"
     gene            5523..6815
                     /db_xref="GeneID:96281529"
                     /locus_tag="STRTU_RS03165"
                     /old_locus_tag="STRTU_000633"
     CDS             5523..6815
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281529"
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088667.1"
                     /locus_tag="STRTU_RS03165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000633"
                     /product="MFS transporter"
                     /protein_id="WP_159742128.1"
                     /transl_table=11
                     /translation="MAPRGRTRWAIGGLLAGGIVVNFLDRTAISVASSSIADEFGLDLQ
                     QLGVVLSAFTWSYCLVQLPAGMLVDVLGVSRLTRIASALWAVAGLLTAVAGGVGPIILA
                     RLLLGVAEGPSMVGASKATASWFPVSERGMATALFDGATKLANMVAFPVLAFVMSEWGW
                     RAGFLFCAAVSVLFTVVWWWGYREPSDYRSLRPAEREFILRGGARDTDRGGLRQFRAAL
                     RSGRVWVVACGFACYGYTINIVLTWMPEFLQREFHVRLLQSGFYSMVPWAVATVAELAV
                     GGWLVDRLIRRGRNPWAVRRTVLTGGLALGGTIGAAGSAGSPAIAVCWMSVSLAGLAIA
                     APVAWGLPGLLAPPGAVGAVSGLMNFLNTAATAGGVLLTGWLAQVSGSFNTPFLFAVGV
                     LAVGVALYWGALRPGTVRDSGAGPVRELDRV"
     misc_feature    5709..5711
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6951..6966
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     gene            7174..8481
                     /db_xref="GeneID:96281530"
                     /locus_tag="STRTU_RS03170"
                     /old_locus_tag="STRTU_000634"
     CDS             7174..8481
                     /codon_start=1
                     /db_xref="GeneID:96281530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601817.1"
                     /locus_tag="STRTU_RS03170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000634"
                     /product="hypothetical protein"
                     /protein_id="WP_159742129.1"
                     /transl_table=11
                     /translation="MNETSVLASCLARLAWPPERLAREINKRCGSGTISSKAPYNWLKG
                     ACPRRRLPYIVAKILSDHLGEPIVVGALWPAHFPSTAPPRRQVTARPHLAAPVRQSSAL
                     DPLTASVDWLVADEALPPPSRARGEEIPGVAIEMLTARIQQLRQLDDSGSSGLVLDWAL
                     QDLQWAERLAAKYAYDASTGRQLHRILAELGQLTAWLTADQGMDELSNSRFLAALDAAR
                     AAGDRPLAAYIISCMSYRAGWAGRAEEALRLIRIARKGSAQEDMGIGQALLATREARAH
                     AGLGDEAACQRALDEAAELSREGKPSAGPPWAYWLTPAVMVADAGRAWLELGRPERAER
                     HLTLGIDMLRGSQPRNLLLHSASLAEARLSRRELDGAAAAATDALALAENVSSQRAHAR
                     LMALRRRFVRYDSAVARDIVQRSDDLLAAGQTRAAC"
     misc_feature    7192..7194
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7213..7215
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8557..9585
                     /db_xref="GeneID:96281531"
                     /locus_tag="STRTU_RS03175"
                     /old_locus_tag="STRTU_000635"
     CDS             8557..9585
                     /EC_number="1.3.1.98"
                     /GO_function="GO:0008762 - UDP-N-acetylmuramate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088665.1"
                     /locus_tag="STRTU_RS03175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000635"
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="WP_159742130.1"
                     /transl_table=11
                     /translation="MRVTHEVLLAPMTTLGLGGPAAVLFELFDPADFPEFVALADAFPA
                     PPVCLGEGSNVVVSDAGCEGAVLRMSTKGVRMTGRADEERVLVEVQAGHLLGDLVGITV
                     AEGLTGMEMLVGIPGTTGATPVQNVGAYGQETADCLLEVTAWDWELGRVVTLDAAACGL
                     GHRTSVFKHSRRWTLLTLVFALRRSELSAPVTYRTVAAALDVPVGSRVPLDEVTQAVLA
                     VRRSKGMVLGCSGTDDRSVGSVFLSPEITPVQADGLRARNAPVNRFPDGSTRVSASWLI
                     RQAGFALSTPIVEGVRMSSLHYTLVADEGATAAGFTRAIELVQQEVLRRTGVRLTSELD
                     FL"
     gene            9794..9934
                     /db_xref="GeneID:96281532"
                     /locus_tag="STRTU_RS03180"
                     /old_locus_tag="STRTU_000636"
     CDS             9794..9934
                     /codon_start=1
                     /db_xref="GeneID:96281532"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="STRTU_RS03180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="STRTU_000636"
                     /product="hypothetical protein"
                     /protein_id="WP_159742131.1"
                     /transl_table=11
                     /translation="MENVTINVDEFDLDLDMEILESATTAVKAQDSKLMTQVCPPTSWH
                     C"
     gene            10001..13201
                     /db_xref="GeneID:96281533"
                     /locus_tag="STRTU_RS03185"
                     /old_locus_tag="STRTU_000637"
     CDS             10001..13201
                     /codon_start=1
                     /db_xref="GeneID:96281533"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="STRTU_RS03185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000637"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_159742132.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.3e-172,
                     bitscore: 574.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-14,
                     bitscore: 53.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.8e-37, bitscore:
                     127.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSQESDEAGMSVRGTGEVAFECGEVALVRAAALPLPSDAPTAAR
                     QSRPSGEAPHEPEESRLRRQITELAAEPRFMEAVSLASASLAAEVDRVLAGERLRLKSL
                     RRIAMALAKYRSRMSHRPTPFGLFAGVGLAGFGTAPVREPIGGRRGVTRPDAAWLDGVL
                     ETLRTVPAVLERSRLTANNLHTVRDGRLVLVDHHDPTGERQLAGSVRHTRVVRHLLAAA
                     ARPTPFPRLVEEAKRQFPQAPGGAVEGSIAQLVRGHFLLTDLTPPPDCTTPLDHLRDRV
                     HGVDHPTAHELRAIHGELGSLDATPPGDRRARLTAVSARMRALRPAADVLQTDLSLDVR
                     LTLPHEVAREAARAATVLWRTSPVHRGNPQLRDYHLAFLERYGTERAVPVLELLDDARG
                     LGLPRAYRQPGAMPSPEAGAARDRVLGELLLDAARRGAREVVLDEETVRALEPEGRGPA
                     PLSMEVVAELVAPGWDALCTGDFDLVLAPQAVSPLAGAMFSRFAPVLGGAGARIQELAR
                     HAERSAPDGEIPACVAYRPRVARSANVSAVPQWLSHRLPLGVGPATTETAHDLRLETLA
                     VHADPDGLRLIDGPTGRRVRPLSYSMLNPGNGHLPYVARFLLELGQEGRSFCAGWSWGR
                     WASAPALPRVRHGRTVLSPARWLPDRALRAAAVQGDAEWGERVGQWRRRWDVPRRVLLT
                     KADHRVAVDLDDPLDLLVLRDEVRRAGDLTLMERFGGRAERQWFRGPEGPHAAEFVFPV
                     FARPPGRSTAHATGRARPVAAAPVPLLTDGPDSGRDARTHLPGGDWLYAKLYVPPARQP
                     EVLARHLGALTDPELLRRAGADLWFFLRYEDPAPHIRLRFHGKPDSLWPVLLPELHSWA
                     RARSAAGLLGQLVLDSYEPEIERYGGPAALGHAERVFHADSESVVTLLAMAPDQLGDPS
                     LPAALGILDILTRLGTPDEALGWLSSPSVLEHRGEVPRARKQEVAALLDAHARPRPPAA
                     ADGWGVGWSTRGPALAGLHEVLSAGGADRDRTGRIALSLAHMHCNRLLGPRPEQERAAR
                     VTAREALALWLGRRRNNQ"
     aSDomain        10535..10801
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_STRTU_RS03185_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.10E-17"
                     /identifier="RREFam001.1"
                     /label="STRTU_RS03185"
                     /locus_tag="STRTU_RS03185"
                     /protein_end="267"
                     /protein_start="178"
                     /score="53.1"
                     /tool="antismash"
                     /translation="TANNLHTVRDGRLVLVDHHDPTGERQLAGSVRHTRVVRHLLAAAA
                     RPTPFPRLVEEAKRQFPQAPGGAVEGSIAQLVRGHFLLTDLTPP"
     misc_feature    10829..10831
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13198..14586
                     /db_xref="GeneID:96281534"
                     /locus_tag="STRTU_RS03190"
                     /old_locus_tag="STRTU_000638"
     CDS             13198..14586
                     /codon_start=1
                     /db_xref="GeneID:96281534"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="STRTU_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000638"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_159742133.1"
                     /sec_met_domain="LANC_like (E-value: 3e-37, bitscore:
                     126.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPLALCDAASDLAYRVADLLSSPERVAATARQALAALPPELLQ
                     PAWQPASLLMGHPGIALLHIRCARNDARYAAVGHAHLTAAVAATAAAGPSMVGDLLLPA
                     QLHADAHGGYTRLLARSAEVHAGYVRAHVARLVARRQDHGPGLAADDYDVTSGLAGEGR
                     GLLQAADRGDERCAEALREVLDFLVGMAHPVRSPTAEGVQVPGWWCAPDRYLVPRDRDT
                     YPNGDLNVGAAHGICGPLALLSLAHRSGHRVPGMTDALRRMADWVVSVGYSDGTGMRWP
                     GRVAASEAAGAPSRPSARGAGARSRPGWCYGTSGIAWALYLAGRALGDHRLTSLAEDAI
                     GGLLRRPLDAAVSTDPGFCHGRAGILHTINRMAAATGRTDWWTAADALARELVAEYDAG
                     TPFGYRQVVPPSPLSGPAPHRVHNPGLLDGAAGIALVLADYADARRGAAVDEVSGWDAA
                     VLMG"
     gene            complement(14727..15491)
                     /db_xref="GeneID:96281535"
                     /locus_tag="STRTU_RS03195"
                     /old_locus_tag="STRTU_000639"
     CDS             complement(14727..15491)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837624.1"
                     /locus_tag="STRTU_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000639"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_159746658.1"
                     /transl_table=11
                     /translation="MERNLAEHACHLHRHIAGMTVADADDLLVADSGIDDDTFNIVAMA
                     RFSSDTADARIADTVRTLAARHRPFSWWVGPASTPWDLSARLTTVGLETSEREVAMWAP
                     LDEATPPENPAGLDIRPVTTREGLADYATVLAANWDPPAATVQHFFALAAERALADDCP
                     ARYLVGYVNNQPVCSAEIFLHAGLAGIYNIATLATHRRRGYGGAITLAALGTARDHGHR
                     TAVLQASADGLPVYRRLGFHDCGQFIEHAISP"
     gene            complement(15822..16106)
                     /db_xref="GeneID:96281536"
                     /locus_tag="STRTU_RS03200"
                     /old_locus_tag="STRTU_000640"
     CDS             complement(15822..16106)
                     /EC_number="3.6.1.7"
                     /codon_start=1
                     /db_xref="GeneID:96281536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088661.1"
                     /locus_tag="STRTU_RS03200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000640"
                     /product="acylphosphatase"
                     /protein_id="WP_174878798.1"
                     /transl_table=11
                     /translation="MIRRRMVVSGDVHGVFFRDTCRRTADELGVSGWVRNLADGTVEAV
                     CEGEPESVRELVDWAHQGPPLATVDAVSVREEEPEGLTGFEIRPTAGGV"
     gene            complement(16177..16950)
                     /db_xref="GeneID:96281537"
                     /locus_tag="STRTU_RS03205"
                     /old_locus_tag="STRTU_000641"
     CDS             complement(16177..16950)
                     /codon_start=1
                     /db_xref="GeneID:96281537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088660.1"
                     /locus_tag="STRTU_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000641"
                     /product="DUF72 domain-containing protein"
                     /protein_id="WP_159742134.1"
                     /transl_table=11
                     /translation="MTVLVGTSGWQYKDWRDVLYPQDRPQRLWLEEYARHFATVESNAA
                     FYRLPEEKTFADWRDRTPDGFVMAVKASRYLTHIKRLREPQEPVGRLMARAAALGPRLG
                     PVLLQLPPTLRADAELLDDCLRCFPTGTRVAVEPRHTSWWTAEIRTVLERRGAALCWAD
                     RGSRPVTPLWRTADWGYLRFHEGRAEPWPRYGRQALTTWARRIADTWPAGADVYTYFNN
                     DPGGAAVRDATHFARAAAATGRSVSRAPSGRGATR"
     gene            complement(17105..18262)
                     /db_xref="GeneID:96281538"
                     /locus_tag="STRTU_RS03210"
                     /old_locus_tag="STRTU_000642"
     CDS             complement(17105..18262)
                     /codon_start=1
                     /db_xref="GeneID:96281538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999768.1"
                     /locus_tag="STRTU_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000642"
                     /product="XdhC/CoxI family protein"
                     /protein_id="WP_159742135.1"
                     /transl_table=11
                     /translation="MLDLAETLHGWLEEGREFAVATVVAVDGSAPRTPGAALAVDSRGT
                     VIGSVSGGCVEAAVHDLCVQALRDGRAVPARFGDHPEDAFAVGLTCGGTIEVLVTPVRA
                     DTPDRQVWAAALTAVGGGAAAALALVARGPAALLGRALLVHPDGSYEGGLDGPPELDRA
                     VADETRALLDAGRTGSFALSERGSRCGSALTLFVESSVPPPRMIVFGAVDFAAALVRTA
                     KFLGYHVTVCDARPVFATRDRFPEADDVVVDWPHRYLRRTGTDGRTVLCVLTHDAKFDI
                     PLLTEALRLPVAFVGAMGSRRTHEDRNRRLREAGVTERELARLHSPIGLDLGARTPEET
                     ALSIAAEIVAVRQGGTGVPLTGSQTPIHHDANERIPGATGPHAAA"
     gene            complement(18255..20402)
                     /db_xref="GeneID:96281539"
                     /locus_tag="STRTU_RS03215"
                     /old_locus_tag="STRTU_000643"
     CDS             complement(18255..20402)
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281539"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713434.1"
                     /locus_tag="STRTU_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000643"
                     /product="xanthine dehydrogenase family protein
                     molybdopterin-binding subunit"
                     /protein_id="WP_159742136.1"
                     /transl_table=11
                     /translation="MTTTTEPRAVTGAVGAAHTRLEGWDKVTGAARYASEIPFAELTHG
                     WLVLSTIARGRIRSVESAPVLAMPGVLAVLHHGNAPRVSGDYTGPLGSPDPILQVFQHD
                     RVPHVGWPVALVVAETPEQAREAAETLIVRYDEEPHDVAFSPGRPGMYTPENSPMSAAE
                     TAKGDLEAELDASAVVVDAEYTTPEEHHSPLEPHAAMARWDSGRLEVVDSNQGSRFVAD
                     ELAKLFSLDPDSVRVRSEHVGGGFGAKATRPHVVLAAMAATVLHRPVRVVLTRRQMFSV
                     VGYRSPTAQRIRLGADPDGRLRAFDHQAESLTSTVHEFIERSADFGRPMYDAEAHYTVN
                     RVVPLDVPTPSWMRAPGEAPGSFALESALDELAEKCAMDPIALRARNEPEVGPVSGLPF
                     SSRRMLACFEEGARRFGWADRDPRPGTRREGRWLLGTGTAAATFPSGVAPSTAAVTAEA
                     DGTFTVRITAADIGTGARTALALVAADALEVAPERIHMKIADSDFGPAMIAGGSMGTRS
                     WAWAITAAVSELREQLALGGGIPPQGITARSDTGEAVMALAKKERHTFGAQFAEVAVDI
                     ASGEVRVRRMLGIFAAGRIVNPLTARSQFIGGMTWGLSMALHEEAVRDQASGGHVGADL
                     AGYHFAAHADVPPIEADWVDDPDPDDPVGIKGIGEVGIVGAAAAIANAVWHATGVRHRH
                     LPIRPDRVLAAATAPGGDRDA"
     gene            complement(20399..21391)
                     /db_xref="GeneID:96281540"
                     /locus_tag="STRTU_RS03220"
                     /old_locus_tag="STRTU_000644"
     CDS             complement(20399..21391)
                     /codon_start=1
                     /db_xref="GeneID:96281540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027599.1"
                     /locus_tag="STRTU_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000644"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_159742137.1"
                     /transl_table=11
                     /translation="MREFGYQRAFDVPGAVALLGADPDARCLGGGTNLVDLMKSGVERP
                     ALLIDVRDLPLGRIEPRDGGGLHIGATVTNSDLAAHPEVRRRYPALAEAVLAGASGQLR
                     NMATVGGNLLQRTRCGYFTDPAKPCNKRVPGSGCPAVAGEHHNHAILGASAHCVAVHPS
                     DMGVALTAFDAVVSYETVDGPGELPLADFYLPVGDTPHRETALPPGALITGLTLPPAPV
                     AATSRYRKVRERASYAFAIGSVAAALDVREGVVQDVRLAFGAVASRPWRAREAERVLTG
                     GPADAEAFAAAADAELAAAETLPHNGYKVTLMRNLVVSVLSELTEEATR"
     gene            complement(21388..21960)
                     /db_xref="GeneID:96281541"
                     /locus_tag="STRTU_RS03225"
                     /old_locus_tag="STRTU_000645"
     CDS             complement(21388..21960)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552072.1"
                     /locus_tag="STRTU_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000645"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_159742138.1"
                     /transl_table=11
                     /translation="MAPSTSSVITLNINGEKRTLPVDHRTTLLDALREQLDLTGTKKGC
                     DHGQCGACTVLLDGRRAVSCLQLAVAAEGCEITTIEGVADGARLHPVQQAFLDLDGYQC
                     GYCTPGQICSAIAVIEEHAAGWPSAATADLRPEAGPPALTAEEIRERMSGNLCRCGAYV
                     SIVQAVAQAAETAAGRTTGSAEGEMAV"
     gene            22303..22881
                     /db_xref="GeneID:96281542"
                     /locus_tag="STRTU_RS03230"
                     /old_locus_tag="STRTU_000646"
     CDS             22303..22881
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281542"
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523194.1"
                     /locus_tag="STRTU_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000646"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_159742139.1"
                     /transl_table=11
                     /translation="MQQRKPAPVRSDAQRNRDRILEVALEELTRSADAPLSTIAKKAGV
                     GQGTFYRNFPNREALVLEVYCHEVQQVSDTASQLLETRAPDQALREWMDRLAQYAMAKA
                     GLAEAMRKATCTHGSLAGLGHGPVTSAVTLLLRANEEAGTIRPGVTPDDFVLAISGLWQ
                     IDPHSDWQPRAERLLDLVMDGLRAGAPGA"
     gene            complement(22998..23615)
                     /db_xref="GeneID:96281543"
                     /locus_tag="STRTU_RS03235"
                     /old_locus_tag="STRTU_000647"
     CDS             complement(22998..23615)
                     /codon_start=1
                     /db_xref="GeneID:96281543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973084.1"
                     /locus_tag="STRTU_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000647"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_159742140.1"
                     /transl_table=11
                     /translation="MRLTKYTHSCVRLERPGAGTLVIDPGIWSEARALHGADAILVTHE
                     HADHVDVLRLKGLGAPVYAPKGADFGGLLDVIEVEPGEEFSAAGFPVTAHGGRHARIYG
                     DLPDCANLGYLIDERLYHPGDSLHVPDKPVETLLVPVQASWLRTSEAIDFVRAIGPERA
                     YGIHDAQINERGLQSVNGWLGEEAGGCYSWVPPGAVSPCSER"
ORIGIN
        1 cgctccgtat cactccggaa agttccgttt acggtcggcc gcctggaggc ggaatcccga
       61 ggtgcaacga ggggtaacga ggggtaacac cagccccttc cctgtcggcc gacccgacaa
      121 tcagggcata tctgaacgga gttgcatcgc cacgccccct cgcgagctca cgctcggcac
      181 ggccgcagcc ttccctctca cacatcgggc agcacggaga gaggggaaat agatgctggg
      241 cgcatccttc cggagtggcc atggggccgt tgccgcccgg ctcgtccggc cgggacacct
      301 gagccgccga ccaccgccgc cccgatgacg agaacccccg ccgaatattc tccgccccgc
      361 gccacaatca aatgcggcga cggagaaggg aattccccgg agatttcttg agctcgattt
      421 cctgcccacc cggccgtccg ggcggttcgg tgagatcctg agagcagggc gacccgccga
      481 gtcccccgcg gtcgccgggg gcggcggacg gaacccgatg caggcggacg gagcccgatt
      541 cacctgggtg cggagcaagg tgacggatat gagcacggcg tggcagtaca cccccatctc
      601 cgccgatggc cggctggggc tcgcggacca gcaccccggc cgcagcgacc cggcctaccg
      661 gcgccgtcgt gacgcactgg ccgcgcgggc cgaagggcat cgcgtggggg cgccctaccc
      721 ggccgtcgac tacaccgagg acgagcaccg cacctggcgg gcggtacacc gggcgctcgg
      781 cccggcacac cacgcccatg cctgccgtgc ggtcctggac gccggtgagg acgcgggaat
      841 ccgcgccgac cggatcccgc agcacacgga ggtcagcgcc ctcctcaccg cccgtacggg
      901 attcgccttc acactggcgg gcggagtggt gcccaatgag cggttcctgg gggcgatggc
      961 acacggctac ttccatgccg tgcagttcgt ccgccacccc gcggttccgc tgtacgcgcc
     1021 cgaacccgat gtcctgcacg acgtcttcgg gcatggcgtc cacctgtcgt gcgcgcgcct
     1081 cgcccggctg taccggctca tcggacaggc cgccaaccgg accgaaaccg atgaagccct
     1141 cgccaccctc agccgggtct actggttcac cctcgaatac gggctgatca ccgaagccgg
     1201 cacccccaag gcgttcggcg ccgccctcct gtcgtcctac ggcgagatcg gcgcccacga
     1261 ccggcggacg atccaccccc tggacctccg tgcggcggcc accaccccgt acctcatctc
     1321 cgggtaccag cccgtcctct acgccgcccg ctccctggaa catctcgaag atgtcctcgg
     1381 cgccttctgc accgacttcg acgacgacag cgcgagccgg ctgtgcgtcc cggcgctccc
     1441 ccgcgaccgg ccctagctcc gatcgcggga ctcccgcccg cccgtcagcc gatccagccg
     1501 ctcgtgaggc ccagcaccgc cgagccgtcc aggtcggtga gcttggtgcc ggtgaactgc
     1561 cgtgcccagt ccgaggtctg gaggcggaac gcgggccggt ccgcggtgag cgcctccagt
     1621 acggcgacgg cggcctcgtc gggggtctgc gcgctgccgt ggaactgcgc gacggtgcgg
     1681 tccaggtacg cctgcagcgc gtccgcgtac gggccggccg cggccacctc gtccgccaga
     1741 tcgaccccga tgttgttcac gaactcggtc gccaccgccc cgggctcgac cacggacacg
     1801 gtcacaccga gccgggccgc caccggcgcc aggctctcca tatagccctc gacggcgaac
     1861 ttggcggcgc agtacgcctc gttgaagggc tgcccgatga ccccgccgac gctggtgacg
     1921 gtgatcagac ggccgccggt cgcgcgcaga tgcggcagtg cggccttcga gacatggagc
     1981 actccgaaga agttcacctc catcaccgtg cgcaccccgg cgacgctctc gttctccagg
     2041 gtgccgaggt gtccggcacc ggcgttgttg atcacggcgt cgagacggcc gtaatcggcg
     2101 atcacaccgt cgaccgcggt ggcgacggag cgctcgtcgg tgacgtccag ctgccggacg
     2161 tcgagctcca ctcccgcctc ctcggccgcc ttgcgcagtg caccggcgcg gccggtgtcc
     2221 cgcagcgtcg cgaccacctg ccagccggcc cgcgccgcgg cgaccgcggc ggccaggccg
     2281 ataccggagg acgtaccggt gatcagaacg accttggacg ggtgagacgt gtgagacgcc
     2341 tgagacgagt gagtcgggtg ggaggacatg gcgaaccttt cggccgtacc gagctgatga
     2401 cgtgcgtgct gaagcacctg atgaagcgcc gcgcaattaa gtgcgtgtac acacaccata
     2461 ggcattacgt gtgcgcacac gcaaccggta gccttgccgc atggcgaaaa ggaagctcac
     2521 ccaggccgag atgcccgtgg ccgatcacgc cttctacggg ctggtctggg ccggaaccgt
     2581 cctcaccgaa cgcgtggacc gcgccctgag caaggcgcac gacctgccgg tctcctggtt
     2641 cgaggtgatg ctctggctcg cctccagccc ggatccggtc ccggcctcgg tgctcggcaa
     2701 cagcaccatg ctcagccgca gccaggtctc ccgcgtcgtg gacgccctcc agagccgcgg
     2761 gctggccacc cgcaccccgt cggcccgcga cgcccgctcc gtcgaggtgt cgctcacccc
     2821 cgacggccac cggctcttcg acgaggccga tgccacccgg cgcgcctgtc tggccccggt
     2881 cttcaccgac ctcctcgacc aggaggacct ggaagcgctc agcaccgtgt ggcggaagct
     2941 caaggccaac aaggagggct gatacggcgg ccccggcacg gcgggcgacc gcgagcgcag
     3001 cgcctgtact gcgcagcgcg gtggacggga ccggtcacga tcgccaggat ctgcggggac
     3061 acgcagtctc agcgacgaga ggcggacgta cggatggcga agcactgggc ggacttccag
     3121 tacgagatct atctccacgg catgaccggt accgtgccgc ggctgccgac cgatctgacc
     3181 cggctggaac agctcgccga gcagcggctg ggccccggcc cggtcggcta tgtggcgggc
     3241 agcgcgggca ccggcagcac cgccgccgcc aaccgggccg cactggaccg ccggcggatc
     3301 gtcccgcgga tgctccgcga tgtgcacgaa cgcgacctgt ccgtggagtt gtggggccgc
     3361 gcgctgcccg caccgctcgc gctcgcgccg gtcggcgtgc tgtcgatcat gcacccggac
     3421 gccgagtcgg ccgccgcgcg ggccgccgcg gcgcacggcg tgccgtacat cctgtcctcc
     3481 gcctccagca cccccatgga gcaggtcgcc gagacgatgg gcgacgggga gcggtggttc
     3541 cagctgtact gggcgaagga ccgcgaggtc accaggagct ttctgaaccg ggccaaggcg
     3601 gccggctaca ccgcgctgtt cgtcacgctc gacaccccgc tcctcgcctg gcggccgcgc
     3661 gatctcgacc aggcgtatct gccgttcctg cacggtgtgg gcaccgccaa ctacttcagc
     3721 gatcccgcgt tccgggcggg gctcgccaag ccggttcacg aggatccgaa cgcggcggtc
     3781 aggcacttcg tggggatgtt cgccgacccc gccaagacct ggccggacct ggccttcctg
     3841 cgggagaact gggacgggcc gatcgtcctc aagggcgtgc tgcacccgga tgacgcgctg
     3901 cgggccgccg aggccggcgt ggacggtgtg gtcgtctcca accacggcgg acgccaggtg
     3961 gcgggctccg tcgccgcggc cgatgcgctg ccccgggtcg ccgaggcggc cgccggccgg
     4021 ctcaccgtgc tcttcgacag cggtatccgc accggcgacg acatcgtcaa ggcgctcgcc
     4081 ctgggcgcgg agtcggtgct ggtggggcgg ccttacgcgt acggtctcgg cctcgacggc
     4141 caggcgggcg tggagcatgt gctgcgctgt ctgctcgccg agttcgatct caccctcgcg
     4201 ctgtccgggc actcccgccc cgccggcctg accgccgacg acctgatcga ggagtccgta
     4261 tgaccaccgc gccgcactcc gcccccaccc ctgagcggca ccccgtgaag aacgtgctcg
     4321 ccgtcgtctc accgcacgtc ggcggccgtt ccgccggagc cgcgctggcc ggcctcttcc
     4381 ccgcccaggc ccgggtcacc gtcgtcgaat cggccgacga ggacccggcg gcgctgcgcg
     4441 aagcacacct cctgatcacc gggctgagtc cggtcaccgc cgcccatctc gccgccgcac
     4501 cacatctgga actcgtccag tgcgccagcc acggcttcga ctacgtcgac ctggacgcgg
     4561 cccgcgagcg gggcatcccg gtctgcaaca tcggctccag cggggcggag aagcagaatg
     4621 tggcggagca gaccttcgcc ctcatgctcg ccctcgccaa gcagctggtc ccggcccaca
     4681 cggccctggt cgaggccgac tgggcgctac cgcgcctcca gcagtcgctg accgaactgt
     4741 ccggcaagac ccttggcatc atcggcctcg gccatatcgg caaggaagtg gcccgccgcg
     4801 ccgtcgcgtt cgacatgacc gtcgtctata cgggaccgag gcccgccgga cccgagaccg
     4861 aggcgcgact gggcggcgcc cgctatctga gcctcaacga cctgctccgc acctccgact
     4921 acctcaccct gcacgccccg ctcaccgacc ggacccgcaa cctgctcgac gccgagcgcc
     4981 tcgccctcct caagcccacc gccttcgtca tcaacaccgc acgcggcgcc ctcatcgacc
     5041 aggacgccct cgcggacgca ctggaggcgg gcaccctcgc cggggccggc ctggacgtct
     5101 tcgaccccga accgcccacg ccggcgctgc gcctgctcaa ggccccgaat gtggtgctct
     5161 cgccgcatgt cgcgggcgtc acccgcgaga ccctggtccg tatcgctctg gcagcggtgc
     5221 agaacgtcat cggccatctg gagggcaagc cgctgcggga catcgtgtcg taacggcggc
     5281 acgcgccacg gcggcacgtg ccgcggcagg tggccccggg gtgcgcgctc ctttcgcaat
     5341 ttcagccatt gttcggcgcg tcggtcagcg ggcccgaaca cagcggcgag gcaccgcggt
     5401 ggcgtgtccc cggcgcgcca ccgccatttc acgacacgcc cgacggctgc cccctcggca
     5461 actggagtag cgtccgcgcg gcattggctc cgacgctcca ccaggaaagg ctggcgcacc
     5521 tcgtggcacc ccgtggacgc acccgttggg cgattggcgg actgctcgcc ggcggtatcg
     5581 tcgtcaactt ccttgaccgt acggcgatat cggtggcgag ctcctcgatc gccgacgagt
     5641 tcgggctgga ccttcagcaa ctcggtgtgg tgctctcggc cttcacctgg tcgtactgcc
     5701 tggtgcagtt acccgccggg atgctcgtgg acgtcctggg cgtttcgcgg ctgacccgga
     5761 tcgcctccgc gctgtgggcc gtcgcgggcc tgctgaccgc ggtggccggc ggggtcgggc
     5821 ccatcatcct ggcgcggctg ctgctcgggg tggccgaagg gccgtcgatg gtcggcgcct
     5881 ccaaggcgac cgcatcgtgg ttcccggtca gtgagcgcgg gatggcgacg gccctgttcg
     5941 acggtgccac caagctcgcc aacatggtgg cgttcccggt gctggcgttc gtgatgagcg
     6001 agtggggctg gcgggccggg ttcctgttct gcgccgcggt cagtgtgctg ttcaccgtgg
     6061 tgtggtggtg gggctaccgg gagccgtccg actaccgctc gctacggccc gcggagcggg
     6121 agttcatcct ccggggcggg gcacgggaca ccgaccgggg aggactgcgg cagttccgcg
     6181 cggccctgcg ctccggccgg gtctgggtcg tggcctgcgg cttcgcctgc tacggctaca
     6241 caatcaatat cgtgctgacc tggatgcccg agttccttca acgggagttc catgtacggc
     6301 tgttgcagtc cggcttctac tcgatggtcc cgtgggcggt ggcgacggtc gccgaactcg
     6361 ctgtgggcgg ctggctggtg gaccgcctga tccgccgggg ccgcaacccg tgggccgtcc
     6421 gcaggaccgt actgaccggt ggtctggcgc tcggcggcac gatcggcgcc gcgggcagcg
     6481 ccggatcacc cgccatcgcg gtctgctgga tgtccgtctc cctggccggc ctggccatcg
     6541 ccgccccggt cgcatgggga ctgcccggac tgctcgcacc gcccggcgcg gtgggggcgg
     6601 tgagcggact gatgaacttc ctcaacacgg cggccaccgc gggcggcgta ctcctcaccg
     6661 gctggctcgc ccaggtgagc ggctccttca acaccccctt cctgttcgcg gtcggcgtgc
     6721 tggcggtcgg ggtcgcgctc tactggggcg cactccggcc gggaacggtg cgggactcgg
     6781 gggccgggcc ggtccgggag ctggacaggg tctgagggct cggggtggcc ttgcgtccga
     6841 agcccagcgg ctcgtggagg tcggcgggtt cgcggtagtg cataggccac ctccatggtc
     6901 gtgcctggcg ccagccccgc gagacgctcc tgcacaccat gtgcagcggc tgtgtccgtc
     6961 ctcacaggtt tggtgtcacg ctccagggca tccctactat ggctgggcag ttgtcggcag
     7021 gggggcgtgg gaagcggcta tgcacaccgt cggcccgatg tcgctgcggt ccgggatgac
     7081 ggcgggcctg cgttcgtcct cggaggcgga cggtcctgcc ccgggcgtcg cgccctcaga
     7141 gttgagcgct cgcgcgggtg aggttctccg gcgatgaatg agacgtctgt gttagcgagc
     7201 tgtctggcgc gattagcctg gccaccggag cggttggccc gtgagatcaa caagcggtgc
     7261 ggcagcggga ccatcagcag caaggcgccg tacaactggc tgaagggcgc ctgcccccgg
     7321 cgtcggctgc cgtacatcgt cgcgaagatc ctgtccgatc acctcggcga gccgatcgtg
     7381 gtcggggcgt tgtggcccgc gcacttcccg tccacggccc cgccgcggcg gcaggtcacc
     7441 gctcggccgc acctcgcggc gcccgtacgg cagtcgtccg cgctcgatcc gctcaccgcg
     7501 tcggtggact ggctggtggc cgacgaagcg ctgccgccgc cctcgcgggc gcgcggcgag
     7561 gagattcccg gggtcgcgat cgagatgctg accgcccgga tccagcagct gcggcagctg
     7621 gacgacagcg gcagcagcgg gctcgtactg gactgggcgc tacaggatct gcagtgggcg
     7681 gaacggctgg ccgccaagta cgcctacgac gcgtcgaccg gacggcagct gcatcggatt
     7741 ctcgccgaac tcggccagct caccgcctgg ttgacggccg atcaggggat ggatgagctg
     7801 agcaactcgc gttttctggc ggccctggat gccgcacggg cggccggcga ccggccgctc
     7861 gccgcgtaca tcatctcctg tatgagctac cgggccggct gggccgggcg ggcggaggag
     7921 gcgctgcggc tgatccggat cgcccgtaag gggtccgcgc aggaggacat gggcatcggc
     7981 caggcgctgc tggccacccg cgaggcccgc gcccatgccg gcctcggcga tgaggcggcc
     8041 tgtcagcggg ccctggacga ggcggccgag ctcagccggg agggcaagcc gtcggccggg
     8101 ccgccctggg catactggct cacccccgcg gtcatggtgg ccgacgccgg ccgggcctgg
     8161 ctggagttgg ggcgccccga gcgggcggag cggcatctca ccctcgggat cgacatgctc
     8221 cggggcagtc agccgcgcaa tctgctgctg cacagcgcct cgctggccga ggcgcgactg
     8281 tcgcgccgcg agctcgacgg cgcggcggcg gccgccacgg acgcgctggc cctggccgag
     8341 aatgtcagct cacagcgcgc ccacgcgcgg ctgatggcgc tgcggcggcg attcgtgcgg
     8401 tacgacagcg cagtggcgcg cgacatcgtg caacggtccg acgatctgct ggccgcgggc
     8461 cagacgcggg cggcgtgctg aggcgtggcc acgaagtccg ctcggccata gcaccgcccc
     8521 tcgacatggg aacggcatcc aggagaacag gaacatatgc gagtcacgca cgaggtactg
     8581 cttgccccga tgacgacgct cggcctcgga gggccggccg cggtcctctt cgagctgttc
     8641 gaccccgcgg acttccccga gttcgtcgcg ctggccgacg ccttccccgc cccgccggtc
     8701 tgtctcggcg agggcagcaa tgtggtggtc agcgatgccg gatgcgaggg cgccgtgctg
     8761 cggatgagca ccaagggcgt ccggatgacc ggccgcgccg acgaggaacg ggtgctggtc
     8821 gaggtgcagg ccggtcacct gctcggcgac ctggtgggca tcaccgtcgc cgagggcctc
     8881 acgggtatgg agatgctggt gggcatcccg gggaccaccg gcgccacacc ggtccagaat
     8941 gtcggtgcct acggtcagga gaccgccgac tgtctgctgg aggtgacggc ctgggactgg
     9001 gagttgggcc gtgtggtcac cctggacgcg gcggcctgcg ggctggggca ccgcaccagc
     9061 gtcttcaagc actcccgccg gtggaccctg ctgaccctgg tcttcgcact gcgccggtcc
     9121 gagctgagcg cgccggtgac ctatcggacg gtcgccgccg cgctggacgt cccggtcggg
     9181 agccgggtgc ccctggacga ggtgacccag gcggtgctgg cggtacggcg gagcaagggc
     9241 atggtgctgg gatgcagcgg caccgatgac agatcggtcg gcagtgtgtt tctcagcccc
     9301 gagatcacgc ccgtacaggc cgacggtctg cgggcgcgca acgcaccggt gaaccgcttc
     9361 cccgacggct cgacgcgggt cagtgcgagc tggctcatcc ggcaggccgg tttcgcgctg
     9421 agtaccccga ttgtcgaggg cgttcgcatg tcgtcactgc actacacact ggtcgccgac
     9481 gagggggcga cggcagccgg attcacccgg gcgatcgagc tcgttcaaca ggaggttttg
     9541 cgccgcaccg gggttcggct cacctccgaa ctcgactttc tctgagtggg gctccgacgg
     9601 ccctatagag gcgttcaagc ggtgcgcggt gtggctgaac agggccccgg agacggggag
     9661 ttgagcccgg gatacgtctt gaaagcgctt gacgcggatc ttgacctcgg atggactatc
     9721 tcggtcgttg cggcattgcg ccgcaacgac ggaaatactc cggaattgaa ttaactttct
     9781 ttggaggggc accatggaga acgtcaccat caacgtggac gaattcgacc tcgacctgga
     9841 catggaaatc ctggagtcgg ccacgaccgc cgtgaaggcg caggactcga agctcatgac
     9901 gcaggtctgc ccgcccacct cctggcactg ctgagacacg ggtgcggggt gctgcaggac
     9961 gtcgtccgcg gcaccccgca ccgtcgtcgg gtgaagcgga gtgcggagtc aggagagcga
    10021 cgaggcgggg atgagcgtgc gcggtacggg tgaggtggcc ttcgagtgcg gggaggtggc
    10081 gctggtacgg gccgcggctc tcccgctgcc ctcggatgcg cccacggcag cccggcagtc
    10141 ccggccgtct ggcgaggccc cgcacgaacc cgaggagagc cgactgcgtc ggcagattac
    10201 ggaactcgcc gccgagccac ggttcatgga ggcggtgagc ctggccagcg cgagcctggc
    10261 ggcggaggtc gaccgggtcc tcgccgggga acggctccgg ctcaagtcgc ttcgccgtat
    10321 cgccatggcg ctggcgaaat accgctcacg gatgtcccac cgccccaccc cgttcggcct
    10381 gttcgccgga gtcgggctcg ccggattcgg gacggcgccc gtacgggagc ccatcggcgg
    10441 caggcgcggt gtgacccggc cggacgcggc ctggctggac ggcgtactgg agacgctgcg
    10501 caccgtcccc gccgtactgg agcgttcacg gctcacggcc aacaacctgc acaccgtgcg
    10561 ggacggccgg ctggtgctcg tcgatcacca tgaccccacc ggggagcggc agttggcggg
    10621 atccgtgcgc cacacccggg tggtccggca cctcctggcg gccgcggcgc gccccacgcc
    10681 ctttccccgg ctggtggagg aggcgaagcg acagttcccg caggcgcccg gcggggcggt
    10741 cgaaggcagc atcgcgcagc tcgtccgcgg ccacttcctg ctgaccgacc tgacgccgcc
    10801 acccgactgc accactcccc tcgatcactt acgcgaccgg gtgcacgggg tcgaccaccc
    10861 caccgctcat gaactgcgcg caatacacgg ggagttgggg tcactggacg ccacgccgcc
    10921 cggcgaccgg cgggcccggc tgaccgcggt ctccgcgcgg atgcgggcgc tgcgaccggc
    10981 cgccgatgtc ctccagaccg acctgtccct ggacgtacgg ctgaccctgc cgcatgaggt
    11041 ggcccgcgag gcggcgcgtg ccgcgacggt gctgtggcgg acctcccccg tccaccgcgg
    11101 caatccgcag ctgcgcgact accacctggc gttcctcgaa cggtatggca ccgagcgggc
    11161 ggtgccggtc ctggaactgc tcgacgacgc ccgtgggctg gggctgcccc gcgcctaccg
    11221 gcagcccgga gccatgccct cccccgaggc cggggcggcg cgcgaccggg tcctcggtga
    11281 gctgctgctg gacgcggccc gtcgtggcgc gcgggaagtg gtgctcgacg aggagaccgt
    11341 acgcgccctg gaaccggagg ggcgcgggcc ggctcccctg agcatggagg tggtggccga
    11401 gctggtggcg cccggctggg acgccctgtg tacgggggac ttcgatctgg tgctcgcgcc
    11461 gcaggcggtg tcgccgctgg ccggggcgat gttcagccgg ttcgcgccgg tgctcggcgg
    11521 ggcgggcgcg cggattcagg agcttgcgcg gcatgcggag cggagcgcac cggacggcga
    11581 gatccctgcc tgtgtcgcct accggcccag ggtggcgcgt tccgccaatg tctccgccgt
    11641 cccgcagtgg ctctcccatc gcctccccct gggcgtcggc cctgccacga cggagacggc
    11701 gcacgatctg cgcctggaga ccctcgcggt ccacgcggat ccggacggcc tccggctcat
    11761 cgacggaccg accggccgca gagtgcgccc gctgtcgtac tcgatgctca acccgggcaa
    11821 cggccatctt ccgtacgtgg cacggttcct gctggaactc gggcaggagg ggcggtcctt
    11881 ctgcgcgggg tggagctggg gacgctgggc gtcggctccc gcgctgccac gggtgcgcca
    11941 cggccggacc gtgctctccc cggcgcgctg gctgccggac cgggccctgc gcgccgcggc
    12001 cgttcaaggg gacgcggagt ggggcgagcg ggtcgggcag tggcggcggc gctgggacgt
    12061 cccccggcgg gtgctgctca ccaaggccga tcaccgcgtc gcggtcgacc tcgacgatcc
    12121 gctggatctg ctggtgctcc gcgacgaggt gcggcgggcg ggcgacttga cgctgatgga
    12181 gcggttcggg ggccgggcgg agcggcagtg gttccggggc cccgagggtc cccatgccgc
    12241 cgagttcgtc tttcccgtct tcgcccggcc ccccggccgg agcaccgccc acgccaccgg
    12301 gcgggcccgc ccggtggcgg cggcgccggt cccgctcctg acggacggcc cggacagcgg
    12361 ccgcgacgcg cgcacgcacc tgcccggcgg cgattggctc tacgccaagc tctatgtgcc
    12421 cccggcacgc cagccggagg tactggcccg tcacctgggc gccctgaccg atcccgagct
    12481 gctccgtcga gcgggcgccg acctctggtt cttcctccgt tacgaggacc cggcaccgca
    12541 catccggttg cgcttccacg gcaagccgga ctccctgtgg ccggtgctgc ttcccgagct
    12601 ccactcctgg gcgcgggcac ggtcggcggc cgggctcctc gggcagctgg tcctggacag
    12661 ctacgagccc gagatcgagc gatacggcgg accggccgcc ctcggccacg ccgaacgcgt
    12721 cttccacgcc gacagcgaat ccgtggtcac gctgctggcc atggcccccg accagctcgg
    12781 cgatccgtca ctgcccgccg ccctgggcat cctcgacatc ctcacccgcc tcggcacccc
    12841 ggacgaggca ctcggctggc tcagcagccc gtcggtactg gagcaccggg gagaggtccc
    12901 acgggcccgg aagcaggagg tcgccgcgct gctcgacgcg cacgcccggc cccggccgcc
    12961 ggccgccgcg gacggctggg gcgtggggtg gagcacccgt ggcccggcgc tggccggact
    13021 gcacgaggtg ctgtccgccg gtggcgcgga ccgtgaccgg acgggccgga tcgccctgag
    13081 cctggcccat atgcactgca accggctgct cggcccgcgg cccgaacagg aacgggcggc
    13141 gcgggtgacg gcccgtgagg cgctggcgct atggctcggc cggaggcgga acaaccaatg
    13201 accgcaccgc tcgcactgtg cgacgcggcg tcggacctcg cctaccgcgt cgccgatctg
    13261 ctcagctcac cggagcgggt ggccgccacc gcccggcagg cgttggccgc actgccgccg
    13321 gaactgctgc aacccgcctg gcagcccgca tcgctgctga tggggcaccc cggcatcgcg
    13381 ctgctgcaca tccggtgcgc ccggaacgac gcccgctatg cggcggtcgg gcacgcccat
    13441 ctcaccgcgg ccgtcgcggc aaccgccgcc gccggcccgt ccatggtcgg cgatctactc
    13501 ctgcccgccc aactgcacgc cgacgcgcac ggcggctata cccggctgct ggcacgcagc
    13561 gccgaggtgc acgccggata cgtccgggcc catgtcgccc ggctggtggc acggcggcag
    13621 gaccatggcc cggggctggc ggccgacgac tacgacgtga cctccggcct ggcgggtgaa
    13681 ggccgcggcc tcctgcaggc ggccgaccgg ggcgacgagc ggtgcgcaga ggcgctccgc
    13741 gaggtcctgg acttcctggt cggcatggca caccccgtcc ggtcccccac ggcagaagga
    13801 gtccaggtgc cggggtggtg gtgcgccccc gaccggtacc tcgtcccccg cgaccgcgat
    13861 acgtacccga acggcgacct caacgtcggt gccgcccacg ggatttgcgg ccccctcgcc
    13921 ctgctgtcgc tggcgcaccg ctccggacac cgggtgccgg ggatgacgga tgccctccgc
    13981 cgcatggccg actgggtggt gagcgtgggg tactccgacg gcacggggat gcggtggccc
    14041 ggccgggtcg ccgcgtcgga ggcggccggg gcgccgtccc ggccgtccgc ccggggagcg
    14101 ggggcgaggt cccggccggg atggtgttac gggacgtccg ggatcgcctg ggccctgtat
    14161 ctggccgggc gggcgctcgg tgaccaccgg ctgacgtccc tggccgagga cgcgatcggc
    14221 ggcctgctgc gccgcccact cgatgccgcc gtatccaccg acccgggctt ctgccatggc
    14281 cgtgcgggca tcctgcacac catcaaccgc atggccgccg ccacggggcg caccgattgg
    14341 tggacggcgg cggacgctct cgcccgggaa ctggtggcgg agtacgacgc cggaactccc
    14401 tttggctacc ggcaagttgt gccaccctca ccgctgtcgg gacccgcacc tcaccgggtg
    14461 cacaaccccg gcctcctgga cggcgccgcc gggatcgcac tcgtactggc tgactacgcc
    14521 gatgcccgcc ggggagccgc cgtcgatgag gtgagcgggt gggacgcggc ggtcttgatg
    14581 ggctgaggcg gggcgtccgg cggctcagat cctttgcctc gcggggctgc tgcgggcgtt
    14641 caccggacgg ctgacgcggc cgttcctcgc gcggggcgca ccgactcggg tctggtgcga
    14701 gagtggccca ggagtagcgg tggttttcag gggctgatgg cgtgttcgat gaactggccg
    14761 cagtcatgga agcccaagcg tcggtagacg ggtaggccgt ccgcagaggc ttgcaggacg
    14821 gcggtccgat ggccgtggtc acgtgcggtg cccaaagcag cgagggtgat ggcgccgcca
    14881 tagccgcgtc ggcgatgggt ggccagcgtg gcgatgttgt agatcccggc gagtcccgca
    14941 tgaaggaaga tctccgccga gcagaccggc tggttgttca cgtagccgac caggtagcgg
    15001 gccgggcagt cgtcggcgag cgcccgctct gcggccaggg cgaagaagtg ctggacggtt
    15061 gcggcgggcg gatcccagtt cgcggccagg accgtggcgt agtcggcgag gccctcgcga
    15121 gtcgtcacgg ggcggatatc gagcccggcg gggttctccg gcggtgtggc ctcgtccagg
    15181 ggcgcccaca tggccacctc ccgttcggac gtctcaaggc cgacggtggt caggcgggcg
    15241 gagagatccc acggggtcga ggcagggccg acccaccacg agaacgggcg atgcctggcg
    15301 gccagcgtcc ggacagtgtc ggcgatgcgc gcgtcggcag tgtccgagct gaagcgggcc
    15361 atggcgacga tgttgaaggt gtcgtcgtcg ataccgctgt cagcgaccag aaggtcatcc
    15421 gcgtcggcaa cggtcatacc cgcaatgtgc cgatgcaggt gacaggcgtg ctcggccagg
    15481 ttccgctcca tccgggtcag cagatccgca tggtccgaag ccggatgtct tatctcaccc
    15541 atggtggttg attccaccac gtgggagtcg gggcggtctc ttgatttggc gctcggcccg
    15601 gcacccgtga tggcggttac caccactcgt tgagcgcggc gaccagtacc gtcgcctcgt
    15661 agcggacggc aaacctgtcg taccgggtcg cgactgcccg gtgcctctta cgcggggcgc
    15721 ccccctcagg gttgcgcctc gcgccggggc gcctcgcgcc gggcaccccc agggcgccgg
    15781 tccatgccgc gcccagcccg gcccagcccg gcccggcccg gtcagacccc tccggctgtc
    15841 ggccggatct cgaagcccgt cagcccctcc ggctcctcct cccgtacgga cacggcgtcg
    15901 acggtggcca gaggcgggcc ctggtgcgcc cagtccacca actcccgcac gctctcgggc
    15961 tctccctcgc acaccgcctc caccgtgccg tccgcaaggt tgcgcaccca gccggacacc
    16021 cccagctcgt cggccgtgcg gcggcaggtg tcgcggaaga acacgccgtg cacgtcgccg
    16081 gagaccacca tccgtctgcg gatcatccgt gtctcacctc gtcagctcgt tcgcccggcc
    16141 cggcggtacg agcgcagata tatcccggcg ccatggtcac cgggtggcgc cacgcccgga
    16201 tggggcacgg ctcacggagc ggcccgtggc cgccgcggca cgggcgaagt gggtggcgtc
    16261 gcggacggcc gcgccgcccg ggtcgttgtt gaagtaggtg tagacgtcgg ccccggccgg
    16321 ccaggtgtcg gcgatccggc gtgcccaggt ggtgagcgcc tgtctgccgt agcgcggcca
    16381 gggttccgcg cggccctcgt ggaagcgcag atacccccag tcggcggtcc gccacagggg
    16441 cgtcacgggt cgggaaccgc ggtccgccca gcacagcgcg gcgccccgcc gctccagcac
    16501 cgtacggatc tccgcggtcc accacgaggt gtggcggggc tcgacggcca cccgggtgcc
    16561 ggtgggaaag cagcggaggc agtcgtccag cagctcggcg tccgcccgta gcgtgggcgg
    16621 tagttggagc aggacgggac cgagacgggg gccgagggcg gcggcccgcg ccatcagccg
    16681 gccgaccggc tcctgcggct cgcgcagccg cttgatgtgg gtcagatagc ggcttgcctt
    16741 tacggccatc acgaacccgt cgggggtccg gtcccgccag tccgcgaagg tcttctcctc
    16801 gggcagccgg tagaaggcgg cattgctctc gacggtcgcg aagtgccgtg cgtactcctc
    16861 cagccacagt cgctgcggcc ggtcctgtgg gtagaggaca tcgcgccagt ccttgtactg
    16921 ccagccggag gttccgacga ggacggtcat gaccgcatgc ctgcccgctc gggggcgggg
    16981 cgtatcagcg ggacgtatca gcggggcgta tcagtcgcct gctctgtaac ccgtcatctc
    17041 gcccgccctc tcgcgggccg tctcgcgggc cacctgggtt cgggcggccc gcgaggcggc
    17101 cgcgttatgc ggccgcatgc ggtccggtcg cgcccggtat tcgttcgttc gcgtcgtggt
    17161 gaatgggggt ttgcgagccg gtcaggggta cgcccgtgcc gccctggcgt acggcgacga
    17221 tctcggccgc gatcgacagg gcggtctcct cgggcgtacg ggccccgagg tcgaggccga
    17281 tcggggagtg cagccgggcc agttcgcgct cggtgacgcc ggcctcgcgc agccggcgat
    17341 tgcggtcctc gtgggtgcgg cgggagccca tcgcgccgac gaacgcgacc ggcagccgca
    17401 gtgcctccgt cagcagcggg atatcgaact tggcgtcgtg ggtgagcacg cacaggaccg
    17461 tgcggccgtc ggtcccggtg cgccggaggt agcggtgcgg ccagtcgacc accacgtcgt
    17521 cggcctccgg gaagcggtcg cgggtggcga agacggggcg ggcgtcgcac accgtcacgt
    17581 ggtagccgag gaatttcgcg gtacgcacca gcgccgcggc gaagtcgacg gcgccgaaga
    17641 cgatcatgcg gggtggcggc acgctcgact cgacgaacag ggtcagcgcg cttccgcagc
    17701 gcgatccgcg ctccgagagg gcgaagctgc cggtgcggcc cgcgtcgagc agggcgcggg
    17761 tctcgtcggc caccgcgcgg tccagctccg gaggcccgtc gaggccgcct tcgtacgagc
    17821 cgtcggggtg cacgagcagg gccctgccga ggagcgcggc ggggccacgg gccacgaggg
    17881 cgagtgccgc cgccgctccc ccgccgacgg ccgtcagcgc cgccgcccac acctgccggt
    17941 ccggtgtgtc agcgcgcacc ggcgtgacca ggacctcgat ggttccgccg caggtcaggc
    18001 ccaccgcgaa ggcatcctcg gggtggtcgc cgaaccgcgc cggcaccgcc cggccgtccc
    18061 ggagcgcctg gacacacagg tcgtggaccg ccgcttccac acagccgccg gagaccgagc
    18121 cgatgaccgt gccccggctg tcgacggcga gggcggcgcc cggggtgcgt ggcgcactgc
    18181 cgtcgacggc cacgaccgtg gcgacggcga actcccgccc ctcctccagc cagccgtgca
    18241 acgtctcggc gaggtcaagc atcccggtct cctcctggtg cggttgcggc cgccaggaca
    18301 cggtcggggc ggatcggcag gtgccggtgg cggacgcctg tcgcatgcca gaccgcgttg
    18361 gcgatggccg ccgcggctcc cacgatcccg acctcgccga tgcccttgat cccgaccggg
    18421 tcgtcggggt ccgggtcgtc cacccagtcc gcctctatgg gcgggacatc ggcatgcgcg
    18481 gcgaagtggt agcccgcgag atcggcgccg acatggccgc ccgaggcctg gtccctgacc
    18541 gcctcctcgt gcagcgccat ggacagtccc caggtcatgc cgccaatgaa ctggctgcgc
    18601 gcggtcagcg gattgacgat tcggcccgcg gcgaagatgc cgagcatccg ccgcacccgc
    18661 acttcgccac tcgcgatgtc cacggcgacc tcggcgaact gcgccccgaa cgtatgccgt
    18721 tccttcttcg ccagcgccat gacggcctcg ccggtgtccg agcgggccgt gatcccctgt
    18781 ggcgggatgc cgccgcccag ggccaattgc tcccgcagct cgctcaccgc ggcggtgatc
    18841 gcccaggccc aggagcgggt gcccatcgag ccgccggcga tcatcgccgg gccgaagtcg
    18901 ctgtccgcga tcttcatatg gatgcgttcc ggggccactt ccagtgcgtc cgcggcgacc
    18961 agggccaatg cggtccgggc cccggttccg atgtccgccg cggtgatccg tacggtgaag
    19021 gtgccgtccg cctccgccgt cacagcggcc gtggacggag cgacgcccga ggggaacgtg
    19081 gccgctgcgg tgccggtgcc gagcagccag cgcccttcgc ggcgggtgcc gggacgcgga
    19141 tcgcggtccg cccagccgaa ccggcgggcg ccctcctcga agcaggcgag catcctgcgg
    19201 ctgctgaagg gcagaccgga gaccggcccc acctccggtt cgttgcgggc gcgcagcgcg
    19261 atcgggtcca tggcgcactt ctcggcgagt tcgtcgagcg cggactccag cgcgaacgag
    19321 cccggtgcct cgcccggtgc gcgcatccag ctcggtgtcg gtacatcgag cgggacgacg
    19381 cggttgacgg tgtagtgcgc ctcggcgtcg tacatcggcc gcccgaagtc ggcgctgcgc
    19441 tcgatgaatt catgcacggt cgaggtgagg gactccgcct ggtggtcgaa tgcgcgcagc
    19501 cgcccgtcgg ggtcggcgcc gagccggatc ctttgcgccg tggggctgcg gtagccgacg
    19561 acggagaaca tctggcggcg ggtcaggacg accctgaccg ggcggtggag gacggtggcg
    19621 gccatcgcgg cgagcaccac atgcgggcgg gtcgccttgg cgccgaagcc accgccgacg
    19681 tgttcggacc gtacccgcac cgagtccggg tcgagcgaga acagcttcgc cagttcatcc
    19741 gccacgaacc tgctgccctg attggagtcg acgacctcca gccggccgct gtcccagcgc
    19801 gccatcgccg catgcggctc caacgggctg tgatgctctt ccggtgtggt gtattcggcg
    19861 tccacgacca ccgcggacgc gtcgagttcg gcctccaggt cccccttcgc cgtctccgcc
    19921 gccgacatgg gggaattctc cggtgtgtac ataccggggc gccccgggga gaaggcgacg
    19981 tcgtgcggct cctcgtcata gcggacgatc agagtctcgg cggcttccct ggcctgctcc
    20041 ggggtttccg cgacgaccag cgccaccggc cagccgacat gcggcacccg gtcgtgctgg
    20101 aagacctgca ggatcgggtc cggtgagccg agcggcccgg tgtagtcccc gctgacgcgc
    20161 ggtgcgttgc cgtggtgcag gaccgcgagg acgccgggca tggccaggac gggcgccgac
    20221 tccacggagc ggatacggcc gcgggcgatc gtggacaaca ccagccagcc gtgggtgagt
    20281 tcggcgaacg ggatctcgct cgcatagcgc gccgctccgg tgaccttgtc ccagccctcc
    20341 agacgggtgt gggcggcgcc gacggccccg gtcaccgcgc ggggttccgt ggtggtggtc
    20401 atcgagtggc ctcctcggtg agttcgctca gcacggacac gacgaggttg cgcatcaggg
    20461 tcaccttgta tccgttgtgg ggcagcgtct cggcggcggc gagttcggcg tccgcggcgg
    20521 cggcgaacgc ctcggcgtcc gccgggcccc cggtcagcac ccgctcggcc tcccgggccc
    20581 gccacggccg ggacgcgacc gccccgaagg cgaggcgcac gtcctggacg acgccctccc
    20641 ggacgtcgag ggcggcggcg accgagccga tcgcgaaggc gtaggacgcc cgctcacgca
    20701 ccttccggta gcgggaggtg gcggcgaccg gcgccggcgg cagggtgagg ccggtgatca
    20761 gcgccccggg cggcagcgcg gtctcccggt gcggggtgtc gcccaccggc agatagaagt
    20821 ccgcgagcgg caactcgccc ggcccgtcca cggtttcgta cgagaccacg gcgtcgaagg
    20881 cggtcagtgc cacccccatg tccgaggggt ggacggccac acagtgggcg gaggcgccca
    20941 ggatggcgtg gttgtggtgc tcgcccgcga cggcggggca gccgctgccg gggacgcgct
    21001 tgttgcacgg cttcgccggg tcggtgaagt agccgcagcg ggtgcgctgg agcagattcc
    21061 cgccgaccgt ggccatattg cgcaactgcc ccgaggcacc ggccagcacg gcctccgcca
    21121 acgccgggta gcgccgccgt acttcggggt gggcggcgag atcgctgttg gtgaccgtcg
    21181 cgccgatgtg cagaccgccg ccgtcccggg gctcgatccg gccgagcggc aggtcgcgta
    21241 cgtcgatgag cagcgcgggc cgttccaccc cggacttcat caggtcgacg aggttggtgc
    21301 cgccgccgag acagcgggcg tcaggatcgg cgccgagcag tgcgaccgcc ccggggacgt
    21361 cgaacgcccg ctgatagccg aattccctca taccgccatc tccccttccg ccgaaccggt
    21421 cgtccgtccg gccgccgtct ccgctgcctg ggccaccgcc tgcacgatcg acacataggc
    21481 accgcagcgg cacagattgc cgctcatccg ctcccggatc tcctcggcgg tcagcgccgg
    21541 tgggcccgct tcggggcgta ggtcggcggt cgcggcactc ggccagcccg ccgcatgctc
    21601 ctctatcacc gcgatggccg agcagatctg ccccggtgtg cagtagccgc actgatagcc
    21661 atcgaggtcg aggaaggcct gctgcaccgg atggagccgc gctccgtccg ccacaccctc
    21721 gatggtggtg atctcgcagc cctcggcggc gaccgcgagc tgcagacagg agacggcccg
    21781 gcgcccgtcg agcagcaccg tgcacgcacc gcactggccg tggtcacagc cctttttggt
    21841 gccggtgaga tcgagctgct cgcgcagcgc gtcgagcagg gtggtgcggt ggtcgacggg
    21901 cagcgtgcgc ttttcgccgt tgatgttcag ggtgatgacg ctggacgtcg atggggccat
    21961 gatcagcctt ctttcgcgtg ggtgaggcgc ggcaggtcgg cccggtggcc aaactggccg
    22021 gccaggacgt cgagctgtcc ttgtcgcgag agagcggggc gtcgaaaggg acggcctcgc
    22081 gtgcggttcg ggaggattgc gctgtacgtg cgggcgtcga caggggttcc tgcggcgggt
    22141 gcggtgggac gaggggccgg tcgctgtgtc ccggccgtcc acgccggccg catccggcgg
    22201 tatggtggac ctaagcggac agctgtccgc tggattctga atctaccgga cagctgtccg
    22261 cttagcaaga ccgatccgtc cgtgatttcg ggaggaggac gagtgcagca gagaaagccc
    22321 gcgccggtgc gctcggacgc gcagcggaat cgcgaccgca ttctggaagt cgccctggag
    22381 gagctgacgc ggtcggccga cgccccgctg agcacgatcg cgaagaaggc gggcgtcgga
    22441 caagggacct tctaccgcaa cttccccaac cgcgaggcgc tggtccttga ggtctactgc
    22501 catgaagtgc agcaggtctc cgacaccgcg tcccagctgc tggagacccg cgcacccgac
    22561 caggccctgc gggagtggat ggaccgcctc gcccagtacg ccatggccaa ggccggtctg
    22621 gccgaggcga tgcgcaaggc cacctgcaca cacggcagtc tggccggact cgggcacggc
    22681 ccggtgacct cagccgtcac cctcctcctg agggcgaacg aagaggccgg caccatccgc
    22741 ccgggggtga cccccgacga cttcgtcctc gccatctccg gcctctggca gatcgatccg
    22801 cacagcgact ggcaaccacg cgccgaacgg ctcctggacc tcgtcatgga cggcctgcgc
    22861 gccggcgcgc ccggggcctg agcgacaccg cgcgtccggg cgggctgagc gagcgccgta
    22921 ccggatcgcc ggaccggctg agcgagcgcc gtccgggatc gccggacggg ccggaagtta
    22981 ccgttccggg cccgcagtca gcgctccgag cagggcgaca ccgcccccgg cggcacccag
    23041 ctgtagcacc cgcccgcttc ctcgccgagc cagccgttga cgctctgcag accccgctcg
    23101 ttgatctgcg cgtcatggat gccgtaggcg cgttccggcc cgatcgcccg gacgaagtcg
    23161 atggcctcgg acgtgcgcag ccacgatgcc tgcacgggca cgagcagggt ctccaccggc
    23221 ttgtccggca catggagcga gtcgccggga tggtagaggc gctcatcgat cagatatccg
    23281 aggttggcgc agtccgggag atcgccgtag atccgcgcat gccgaccgcc gtgcgccgtg
    23341 acagggaagc cggccgcgct gaactcctcg cccggctcca cctcgatgac atccaggagg
    23401 ccgccgaagt ccgcgccctt gggtgcgtag acgggcgcgc cgagtccctt gagccgcagc
    23461 acgtcgacgt ggtcggcatg ttcgtgcgtc accaggatcg cgtcggcacc gtgcagcgcc
    23521 cgtgcctcgc tccagatgcc ggggtcgatg accagtgtcc cggcccccgg acgctccagc
    23581 cggacacagg aatgtgtgta cttggtaaga cgcatggccc ctcgcaaaga caactcccta
    23641 aatcctgtcc gtcacatcca cgctccgata ggccagctcg cgtggtgtca gcgtgagctt
    23701 cagccggtgc ctggccgtgg cggccgacga ggtgccgccg gcgtccgtga tcacccaggt
    23761 gcggacaccg gaccgtgccc gggggtcgcg ttccagctcg acggtgaact ccagctcgat
    23821 cggtcccatc tcgaactgca ggtcaccgcc gtcgaacgtg cgggtggccg cgcgcagatc
    23881 gtcgcgtacg gcctgcaccg cttcggtgag gtcaatccgg ttccggtcca tgctccgctg
    23941 ctctctgtgt ggctgtgcga catcgtcgac gggttcaaca cgatggatct ctacatgcgc
    24001 cgggatgctg cccaatcccg aggtggccga gtacgcgtcg gcctcggcgg ccaggtggta
    24061 ggcggacagc gcctcgcccg cgacgtcccc gctcccctgc tctcctcccg ccagtacggc
    24121 gtgcagctgc tgggcccggc tccgctccgc cgccagagcc gagttgcccg tcgtggagag
    24181 ccggtcgtac agcgtgaggg actcttccag gagggccagg gcctgctccc actcggcgcg
    24241 ggaggccagc agggtggcga gattgtgcag accacgcgcc agttccggtg ccacgctcgg
    24301 gtcctcctcg aacagtgccc ggtatcccct gatcgcccgt tgcgaggcag cgacggcctc
    24361 cgccgtgcgt cccgatgagc cgaggatcag cgcgaggcat tcgagcgcgt tgcagcgcag
    24421 ccgctgcgcg ggcggccgga gctgtgccgg cagggtgtgg gtgagcgcga tgcattcctg
    24481 cagtacgtcc accgcctctt cggacgcccc gacctcggcc agacagagcc ccagctgtag
    24541 cagtgcatgc gccaggccgg ttccgacgga gcggtatcgg tcgagg
//
