LOCUS       NZ_CP114205            12980 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces tubercidicus strain DSM 40261 chromosome, complete
            genome.
ACCESSION   NZ_CP114205
VERSION     NZ_CP114205.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tubercidicus
  ORGANISM  Streptomyces tubercidicus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8284047)
  AUTHORS   Ruckert,C., Busche,T., Kalinowski,J. and Wittmann,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2022) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-MAR-2022
            Assembly Method                   :: flye v. 2.9; Newbler v. 2.8
            Assembly Name                     :: DSM40261_v1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 133.7x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/09/2024 02:53:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,167
            CDSs (total)                      :: 7,077
            Genes (coding)                    :: 6,906
            CDSs (with protein)               :: 6,906
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 171
            CDSs (without protein)            :: 171
            Pseudo Genes (ambiguous residues) :: 0 of 171
            Pseudo Genes (frameshifted)       :: 72 of 171
            Pseudo Genes (incomplete)         :: 133 of 171
            Pseudo Genes (internal stop)      :: 9 of 171
            Pseudo Genes (multiple problems)  :: 41 of 171
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:04:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 157522
            Orig. end                         :: 170502
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP114205.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from DSM 40261.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..12980
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="2"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12980
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12980
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7980](-)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7980)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     misc_feature    143..156
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(929..942)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.91"
                     /tool="antismash"
     gene            1327..1512
                     /db_xref="GeneID:96281046"
                     /locus_tag="STRTU_RS00730"
                     /old_locus_tag="STRTU_000146"
     CDS             1327..1512
                     /codon_start=1
                     /db_xref="GeneID:96281046"
                     /inference="COORDINATES: protein motif:HMM:NF024989.4"
                     /locus_tag="STRTU_RS00730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000146"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_269777153.1"
                     /transl_table=11
                     /translation="MAGGETGEFTLPVRGLDGWLRDGEIDASVGGTYPLEEAAHAHRDL
                     QQRRSTGKLLLSPEGS"
     gene            complement(1493..2083)
                     /db_xref="GeneID:96281047"
                     /locus_tag="STRTU_RS00735"
                     /old_locus_tag="STRTU_000147"
     CDS             complement(1493..2083)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281047"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067480.1"
                     /locus_tag="STRTU_RS00735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000147"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_269777154.1"
                     /transl_table=11
                     /translation="MNASVILRAPATPALPALVLRPWCLEDVDALVAAYRDPMLGRWAR
                     SRPENEAQGVQWIQDQQRGWSVGDRFGFAVLEESPDEAAPRLVGNVILKDVAPGKPTAE
                     AGYWTAGHARGRGVAARALEALTTWAFETFHAEGLEAIELLHQVDNLASCRVAEKCGYT
                     FARTLPAAPPRYPLESHLHLRHGALRSFKSPQG"
     gene            complement(2080..2772)
                     /db_xref="GeneID:96281048"
                     /locus_tag="STRTU_RS00740"
                     /old_locus_tag="STRTU_000148"
     CDS             complement(2080..2772)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281048"
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608085.1"
                     /locus_tag="STRTU_RS00740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000148"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_269777155.1"
                     /transl_table=11
                     /translation="MGHLKHRDLNATRERLRDQVAHALRAALISGELRPGEVYSAPVLA
                     EDFGISATPVREAMLDLAREGLVEPVRNKGFRVTEVNERDLDQYTEIRALIEIPMVGRI
                     TRTAARAELEALRPVAEEIVRAARDHDLIGYLEADRQFHLELLGLSGNDRLVETVGDLR
                     KRSRLYGLTALDEQGELIPSAEEHHELLDLMLAGDAKAAEKCMAKHLGHVRSLWARSGT
                     AATSSPAR"
     misc_feature    complement(2803..2821)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.39"
                     /tool="antismash"
     misc_feature    2810..2826
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.14"
                     /tool="antismash"
     misc_feature    2814..2824
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            complement(2876..3880)
                     /db_xref="GeneID:96281049"
                     /locus_tag="STRTU_RS00745"
                     /old_locus_tag="STRTU_000149"
     CDS             complement(2876..3880)
                     /codon_start=1
                     /db_xref="GeneID:96281049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891275.1"
                     /locus_tag="STRTU_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000149"
                     /product="proline racemase family protein"
                     /protein_id="WP_269777156.1"
                     /transl_table=11
                     /translation="MRTRHVFHAVDSHTEGMPTRVITGGVGVLPGATMAERRLHFIEHL
                     DHLRTLLMYEPRGHSAMSGAILQPPTRADADYGVLYIEVSGLLPMCGHGTIGVATVLVE
                     SGMVPVTEPVTPVRLDTPAGLVAVDVQVADGVAKSVTLTNVPAFCAGLDRTVEVPGYGT
                     VTYDLAFGGNFYAFVELDALGLPFDRARKDDLLAAGLAVMAAINASPDRPVHPEQPEIA
                     GVKHVYLAAPGSDAHHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGELPLDRDFVNE
                     SFIGTRFTGRLIAETEVGGRPAVVPTVTGRAWITGTAQYFLDPDDPFPGGFLL"
     gene            complement(3977..4897)
                     /db_xref="GeneID:96281050"
                     /locus_tag="STRTU_RS00750"
                     /old_locus_tag="STRTU_000150"
     CDS             complement(3977..4897)
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938965.1"
                     /locus_tag="STRTU_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000150"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_269777157.1"
                     /transl_table=11
                     /translation="MTASATAITWNSSRPWRGIMVATALPLRDDLSVDYDAYARHVRWL
                     IEQGCDGVVPNGSLGEYQTLTDEERARVVRTAVEAAGDGARVMPGVAAYGSAESRRWAE
                     QAGEAGCGSVLLLPPNAYRADEPAVRAHYAEAAKAGVPVVAYNNPLDTKVDLTPGLLAR
                     LHQDGSIVAVKEFSGDVRRAYEIAELAPELDLLIGADDVLLELAVAGAVGWIAGYPNAF
                     PATCATLYHAAVAGDLDTALPLYKSLHALLRWDSKTEFVQCIKLSMDLVGRRGGPARPP
                     RSPLTGETEAEVRAATEKAVAAGHH"
     gene            complement(5001..6494)
                     /db_xref="GeneID:96281051"
                     /locus_tag="STRTU_RS00755"
                     /old_locus_tag="STRTU_000151"
     CDS             complement(5001..6494)
                     /codon_start=1
                     /db_xref="GeneID:96281051"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091457.1"
                     /locus_tag="STRTU_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000151"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_269777158.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.3e-21, bitscore:
                     75.0, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 5.8e-10, bitscore:
                     38.1, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVSASDPYDLAVIGAGSAGLAGAVTAAGLGLSVALLDAAPQTGG
                     QFYRHPARAIGAARPEALHHDWAAFAALRRRLERSDVRHLPGHHVWAVTQEDGEQWAVH
                     AVTGADGTAERSVRVRARTVLLATGAYERQLPFPGWTVPGVVGAGGAQAMLKSGLVLPG
                     KRIVVAGSGPLLLAVASSLAVAGARVPAVIEASGYLGYARHPRALAAHPHKLVEAAVHG
                     AALLRHRVRLCTRSAVTEVHGTERVAAVTVTRLDRDWRPVRGTGRRIDCDALAVGHGLV
                     PQIELATALGCATRRTTDGTLALTLDALQETSVRGLWAAGETGGVGGTQLALAEGELAG
                     LAAAARLHGHPVHEGRLRALRRRRDRMRAFAEAMAVSHAPAAGWTDWLTDDTEVCRCEE
                     VTAGTIRAAVSGLGAHDARTVKLLTRAGMGWCQGRMCGTATACLAAGEGAAEPPAAHRP
                     VEPPAERRPLAVPVPLSALAASPDEPAGGRPDTAPADGD"
     gene            complement(6475..6789)
                     /db_xref="GeneID:96281052"
                     /locus_tag="STRTU_RS00760"
                     /old_locus_tag="STRTU_000152"
     CDS             complement(6475..6789)
                     /codon_start=1
                     /db_xref="GeneID:96281052"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091458.1"
                     /locus_tag="STRTU_RS00760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000152"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_269777159.1"
                     /sec_met_domain="Fer2_4 (E-value: 1.9e-24, bitscore: 84.2,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARTPAELAGANSGAPFEITMDGRPVPALPGQSVAAALWSAGILA
                     WRTTRTTGRPRGAFCGIGQCYDCLATINGEPNRRACLVPARPGDAITTQEGHGHARIGV
                     "
     gene            complement(6817..7980)
                     /db_xref="GeneID:96281053"
                     /locus_tag="STRTU_RS00765"
                     /old_locus_tag="STRTU_000153"
     CDS             complement(6817..7980)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96281053"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938974.1"
                     /locus_tag="STRTU_RS00765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRTU_000153"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_269777160.1"
                     /sec_met_domain="DAO (E-value: 3.6e-69, bitscore: 232.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSGRISDVSDVIVVGAGVVGAACAYYAARAGLSVTVLDRGSVAG
                     GTTGAGEGNLLVSDKEPGPELALALLSTRLWRELAELLPPQIEYEAKGGLVVASDEAGM
                     GALRDFAAGQDKAGVRAEEIPADRLPELEPHLTPGLAGGFHYPQDAQVMPALAAAHLLR
                     AGGDRVRVRLGEEVTGLLTTPDGAVRGVRTTAGEVSAPYVVNAAGTWGGVFARLAGVGL
                     PVLPRRGFVLVTEPLPRVVRRKVYAADYVADVASGSAALQTSAVVEGTAAGPVLIGASR
                     ERVGFDRTVSTEVLHRLAAQATALFPALAGVRALRTYVGFRPYLPDHLPAIGPDPRVPG
                     LLHACGHEGAGIGLAPATGLLIAQALSGEQPPLEASPFSPARFASAD"
     misc_feature    complement(7984..7999)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.3"
                     /tool="antismash"
     misc_feature    complement(7992..8002)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    complement(8152..8164)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    9062..9074
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    12534..12554
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.36"
                     /tool="antismash"
ORIGIN
        1 cagctccgcg tcccgtccgg ccgggaccgc ggtcccggcg aggcggctca tgccctgctt
       61 gaggcaggac cgggcgatgg agtcgccctg gagcagggtg cgggagttga cgtgcgggcg
      121 ggcgccgatc gcggtgaccc actggaccga ctccaccgga ggaccgtagg agaatcgggc
      181 cgggtggggg acgccccggg cgtcgatgag ctggaaggtc acatccgtga cgtccaggcc
      241 gcccgtctcg tagccggggc ctgccgcgtc ggggatgaag tgggcgcggc atccgcccgc
      301 ggaacggagc gacgccagca gcgggtcggt ggcccggcgc acgtcggtcg tcggcaggtg
      361 agcctcgacg agtgccgtca cacgaagcgg cgggcccggc acctggggcg agccgacgag
      421 gaaggcgccg gactcctcgt ccgccgtcat cctcatgcgc gggccgagca gctggacgac
      481 gcccgcctcg accagggcgc ggagctcccg gacgcgcgtg gccggcggcc cgctggcggc
      541 gtagttgttc aagccgctga accagtggtc gatgtggtcc cggtaggaag caccgctcag
      601 gccccggtgg gagatgacct gccgcacctc gtcgcgcagg tcacgcatga ccgcggcggc
      661 agccttgacg gcgctgacgg ccgggcccag atccgagtgc cgcagatcct catcgaggac
      721 gccgaggatc cacgcgcggt aatcggcgga gtcggtgaac tccctgcggt ccgccggccg
      781 gtcgagtgcc tcccagttcc agcgcagttc cggatcgggc accaggtcgc tcaggagcgc
      841 ctccatgccg ggggatcccc aggcgtgccg cggatactcg gccagcagcc gggcgtgccc
      901 ggtcgggtcg tcggtctgca acagcacctt gtagtagttc caggcgacct ccttcgccac
      961 gagggggaac aggtcgcgca ggaagtcggt gcgaccggtg cccgccgggc tcctcagccg
     1021 ggcgatctcg tcggcggaca ggaacgtcgc ccggtaacgg ggcacgatct cctgacggat
     1081 ctccgcccgc gcgcgatatg gcacaccgcg ccccgaaccg gcgtgcacca ccaattcgtt
     1141 gccgctcggc agataggtca gccggccgtc ggaaccgggg acgaaacgcc cgcccctgcc
     1201 ctcggtgagc aaggccatgt agtcgtagaa attcagcccg agtccgcgca gagcgacggg
     1261 ctgacccgcg ccgaccggcg ccaggtccgc ctccgccggg ctgctcggcg ggacgtagtg
     1321 cagaccgtgg cgggaggcga aaccggcgag ttcacgctgc ctgtccgtgg gctcgacggc
     1381 tggctgcgcg acggtgagat cgacgcctcc gtcggcggga cctacccgct ggaggaggcg
     1441 gcccacgccc accgcgatct ccagcagcgc cgctccacgg gcaagctcct cctcagccct
     1501 gagggctctt gaagctcctg agcgcgccgt gccgcaggtg cagatggctc tcaagggggt
     1561 atcgcggcgg cgccgccggc agagtccgtg cgaacgtgta gccgcacttc tccgcgacac
     1621 ggcacgaggc gaggttgtcc acctggtgca gaagctcgat ggcttccagc ccctcggcgt
     1681 ggaaggtctc gaaggcccag gtggtcagcg cttccagagc gcgtgcggcg acgccccgtc
     1741 cacgtgcgtg tcctgctgtc cagtagccgg cttcggcagt cggtttgccg ggagcgacgt
     1801 ccttgaggat cacattgccc accaaccgtg gggcagcctc atcgggagac tcttccagga
     1861 cggcgaagcc gaatcggtct cccacggacc agcctcgctg ctggtcctgt atccactgca
     1921 ccccttgcgc ctcgttttcc ggccgtgacc tggcccagcg tcccagcatg ggatcccggt
     1981 acgccgccac cagtgcgtcc acgtcctcca ggcaccaggg gcggagaacg agcgcgggca
     2041 gggccggtgt tgcgggcgcg cgcaggatca cggaagcgtt caccgggcag gtgatgaggt
     2101 cgccgcggtc ccgctcctgg cccagagtga gcggacatgg cccaggtgct tggccatgca
     2161 cttctcggct gccttcgcgt cgcccgccag catcagatcg aggagttcgt ggtgctcctc
     2221 ggccgacggg atcagctcgc cctgctcgtc cagggcggtg agcccgtaca gccgcgagcg
     2281 tttgcgcaga tcgccgacgg tctcgacgag gcggtcattg ccgctgaggc cgagcagttc
     2341 gaggtggaac tgccggtcgg cctccaggta gccgatgagg tcgtggtcgc gggcggctcg
     2401 tacgatctcc tcggcgaccg gccgcagcgc ttccagctcc gcgcgggcgg cggtgcgggt
     2461 gatccggccg accatgggga tctcgatgag cgcgcggatt tcggtgtact ggtcgagatc
     2521 gcgttcattg acttcggtga cccggaagcc cttgttgcgg acgggctcga ccaggccctc
     2581 gcgcgccaga tcgagcatcg cctcgcgcac gggcgtggcc gagatcccga agtcctcggc
     2641 cagcaccggc gccgagtaca cctcccccgg ccgcagctca ccggagatca gggcggcgcg
     2701 cagggcgtgg gcgacctggt cgcgcaaccg ctcccgggtg gcattgagat cgcggtgctt
     2761 caggtgcccc ataacggtgg tgatcccttc atgccggagc ggaatcacca gcatacaatt
     2821 tcacattttg tcagtggtcc agagggggga gagtcagccg ggggacggcc ggtggtcaca
     2881 ggaggaagcc cccgggaaac gggtcgtccg ggtcgaggaa gtactgggcg gtgccagtga
     2941 tccaggcgcg gccggtgacg gtcgggacga cggcgggccg tccgccgacc tcggtctcgg
     3001 cgatcagccg gccggtgaag cgggtgccga tgaaggactc gttgacgaag tcgcggtcca
     3061 ggggcagttc accgcgggcg tgcagctgcg ccatccgcgc cgaggtgccg gtgccgcagg
     3121 gtgagcggtc gaaccagccg ggatggatcg ccatcgcatg ccgtgagtgg tgggcgtccg
     3181 agccgggagc ggccaggtag acatgcttga ccccggcgat ctccggctgc tcggggtgga
     3241 ccggccggtc cggtgaggcg ttgattgccg ccatgacggc cagcccggcg gccagcaggt
     3301 cgtccttgcg ggcacggtcg aacggcagcc ccagcgcgtc gagttcgacg aaggcgtaga
     3361 agttgccgcc gaaggcgagg tcataggtca ccgtcccgta tcccgggacc tccacggtgc
     3421 ggtccaaccc ggcgcagaag gcgggcacat tggtgagggt gaccgacttc gccaccccgt
     3481 ccgccacctg gacatcgacg gcgaccagac cggccggggt gtcgagccgc accggggtga
     3541 ccggctcggt caccggcacc atgcccgact cgacgaggac ggtggcgacg ccgatggtgc
     3601 cgtgcccgca catcggcagc aggccggaga cctcgatata gagcacgccg tagtcggcgt
     3661 cggcgcgggt gggcggctgg aggatggcgc cgctcatggc ggagtgcccg cgcggctcgt
     3721 acatcaggag cgttctgaga tggtcgaggt gctcgatgaa gtggagcctg cgctcggcca
     3781 tggtggcgcc ggggagcaca ccgacaccac cggtgatcac gcgcgtgggc atgccctcgg
     3841 tgtgcgaatc gacggcgtgg aagacatgac gcgtacgcac gatgagtcct ttcgaagcgg
     3901 cacggaagcg gtcagctgat gcggtcgact gatgcggtca gctggtgcgg tgaagtgatc
     3961 cggtcaagtg atgcggtcag tggtgtccgg cggccacggc cttctcggtg gcggcccgta
     4021 cttcggcctc ggtctccccc gtgagcgggg agcgcggcgg gcgggcgggg ccgccgcgac
     4081 ggccgacgag gtccatggac agcttgatgc actggacgaa ctcggtcttc gaatcccagc
     4141 gcagcagcgc gtgcagggac ttgtagagcg gcagggcggt gtccaggtca ccggcgacgg
     4201 cggcgtggta cagcgtggcg caggtggcgg ggaaggcgtt ggggtagccg gcgatccagc
     4261 cgaccgcacc ggccacggcg agttcgagca ggacatcgtc cgcgccgatc aacaggtcca
     4321 gttccggggc gagttcggcg atctcgtagg cgcgccgcac atcgccggag aactccttga
     4381 ccgcgacgat gctgccgtcc tggtggagcc gggccagcag cccgggtgtc agatccacct
     4441 tggtgtcgag ggggttgttg tacgcgacga ccggtacgcc cgccttggcg gcctcggcgt
     4501 aatgggcgcg gacggccggt tcgtcggcgc ggtaggcgtt cgggggcagc aggaggaccg
     4561 agccgcagcc cgcctcgccc gcctgctccg cccagcggcg ggactcggcg ctgccgtacg
     4621 cggccacacc gggcatcacc cgcgccccgt cacccgccgc ttcgaccgcg gtccgcacca
     4681 cgcgggcccg ctcctcgtcg gtgagggtct ggtactcgcc gagcgagccg ttcggtacga
     4741 cgccgtcgca gccctgctcg atcagccagc ggacgtgccg ggcgtaggcg tcgtaatcga
     4801 cggacagatc gtcgcgcagg ggcagcgccg tggcgaccat gattccgcgc caggggcggc
     4861 tgctgttcca ggtgatggcg gtggcggagg cggtcatgct ggtgaacctt tctctcgcgt
     4921 gtgacaggtg tacggctctc gttgtgggct tttttgttgg ctggtgtgca gcggcccccg
     4981 caaggggcgg ggccggtgga tcagtcgccg tcggccgggg cggtgtccgg ccggcctccg
     5041 gcgggctcgt cgggtgaggc ggcgagcgcc gagagcggaa cgggtaccgc gagcgggcgg
     5101 cgttcggcgg gtggttcgac cgggcggtgc gcggcgggtg gttccgcggc tccttcgccc
     5161 gccgcgaggc aggcggtggc cgtaccgcac atccggccct gacaccaacc cataccggcc
     5221 cgggtgagga gtttgacggt gcgtgcgtca tgggcgccga ggccgctgac ggccgcgcga
     5281 atcgttccgg cagtcacttc ctcgcagcgg cagacctccg tgtcgtcggt cagccagtcg
     5341 gtccagcccg ccgccggtgc atggctgacg gccatcgcct cggcgaaggc gcgcatccgg
     5401 tcccgccgac gccgcagcgc ccgcaggcgc ccttcgtgga cgggatgccc gtggagcctg
     5461 gcggctgccg cgagtccggc caattctcct tcggcgaggg cgagttgggt gccccctact
     5521 cccccggtct cccccgccgc ccacagaccg cgtaccgagg tctcctgaag ggcgtccagg
     5581 gtcagggcca gggtcccatc ggtggtgcgg cgggtggcgc agccgagtgc ggtggccagt
     5641 tcgatctgcg ggaccaggcc gtgtcccacc gcgagcgcgt cgcagtcgat ccgacggccc
     5701 gtcccccgta cgggccgcca gtcgcggtcg agccgggtga cggtgacggc cgccacccgt
     5761 tcggtgccgt gcacctcggt gaccgcgctg cgggtacaca gccggacccg gtgccgcagc
     5821 agcgcggccc cgtggaccgc cgcctcgacg agcttgtgcg gatgggccgc gagcgcacgg
     5881 ggatggcgcg cgtatcccag ataaccggac gcctcgatca cggcggggac ccgcgcaccg
     5941 gcgacggcca gcgacgaggc gaccgcgagc agcagggggc cactgcccgc cacgacgatc
     6001 cgcttgccgg gcagcaccag cccggatttg agcatggcct gcgctccccc ggctcccaca
     6061 actcccggca ccgtccagcc gggaaagggg agttgacgtt cataggcgcc ggtcgcgagc
     6121 agcaccgtac gggcccgcac ccgcaccgac cgctcggcgg tgccgtcggc cccggtgacg
     6181 gcgtgcaccg cccactgctc accgtcctcc tgggtgacgg cccagacatg gtgccccggc
     6241 agatgacgga catcgcttcg ctccaggcgt cggcgcagtg cggcgaaggc cgcccagtcg
     6301 tggtgcagcg cctcgggccg ggccgcgccg atggcccgcg cgggatgccg gtagaactgt
     6361 ccgccggtct gcggcgcggc gtccaacagg gccacggaca ggccgagtcc ggctgccgtg
     6421 acggcgccgg cgagaccggc ggagcccgcg ccgatcaccg cgaggtcgta cgggtcagac
     6481 gccgatacgg gcatggccgt gtccctcctg ggtggtgatc gcgtcaccgg ggcgggcggg
     6541 caccagacag gcccggcggt tgggctcccc attgatggtg gccaggcagt cgtagcactg
     6601 tccgatgccg cagaaggcgc cgcgcgggcg accggtggtg cgggtcgtcc gccaggcgag
     6661 gatgccggcg gaccacaggg ccgcggcgac ggactggccg ggcagggcgg ggaccggacg
     6721 gccgtccatc gtgatctcga acggtgcgcc ggagttcgcc cctgccagtt cagcgggcgt
     6781 acgggccact gctggcctcc tctcgtcacg gacgggtcag tcggcggatg cgaagcgggc
     6841 ggggctgaac gggcttgctt ccaggggtgg ttgctcaccg ctcagggcct gcgcgatcag
     6901 gagcccggtg gccggggcga gaccgatccc cgcgccctcg tgaccgcagg cgtgcagcag
     6961 accgggcacc cgcggatcgg ggccgatggc cggcaggtgg tcgggcaggt agggccggaa
     7021 ccccacgtac gtccgcagcg cgcggacccc ggcgagggcc gggaacagtg cggtggcctg
     7081 ggccgccaga cggtgcagca cctcggtcga caccgtccgg tcgaagccga cccgttcccg
     7141 gctggccccg atcaggacgg gtccggccgc ggtcccctcg accaccgccg aggtctgcag
     7201 cgccgccgag ccgctggcga cgtcggcaac gtagtcggcc gcgtacacct tgcgccgtac
     7261 cacccgcggc agcggctccg tgacgaggac gaaaccgcgg cgcggcagca ccggcagccc
     7321 gacgcccgcg agccgggcga acacaccgcc ccaggtaccg gccgcgttga ccacgtacgg
     7381 ggccgacacc tcgccggccg tcgtccgcac cccccgcacc gctccgtccg gtgtggtcag
     7441 caggccggtg acctcctcgc cgagccgcac gcgcacccgg tcaccgcccg cgcgcagcag
     7501 atgcgcggcg gccagggccg gcatcacctg ggcatcctgc ggatagtgaa acccccctgc
     7561 cagaccggga gtcagatgcg gttccagctc cggcagccgg tccgcgggga tctcctccgc
     7621 cctcactccg gccttgtcct gtccggccgc gaagtcgcgc agggcgccca ttccggcctc
     7681 atcggaggcg accaccaggc cgcccttggc ctcgtactcg atctgcggcg ggagaagttc
     7741 cgccagctcc cgccacaacc gggtggacag cagcgcgaga gcgagttcgg gaccgggttc
     7801 cttgtcggag accaggagat tgccctcgcc ggcacccgtc gtgccgcccg cgaccgagcc
     7861 gcggtcgagc acggtgacgg agagcccggc gcgggccgcg tagtaggcgc aggccgcgcc
     7921 gaccacgccc gctccgacga cgatgacatc cgagacatcc gagattcttc ccgagagcac
     7981 atcagtaata tttcacattg cactggccct gccaagggtg gcgcgtgatc cggccgcaac
     8041 tcccccggag ccggggcccg tcgcccgttg cccattgccc attgcccgcc atcgcgtccg
     8101 gattcttcac gagtcctcgg gccggggtaa gtcacggacg cgccaacagt cgtgacagcg
     8161 gcgccctttc cgtcagacga ccagctggct cgtggtgccg gtggagggcg cgaagctgac
     8221 atcgccgttg tagttgccgg tgaccaagtg gaggcccctg ggaagcgggt tgaaggtcgc
     8281 gctggcctgt ccgccgacga gaggcacggt ctggggggtg cgtcccggga tggcgagggt
     8341 gacggtcccg gtgggcgtac ccgttccggg ggcgacggga accacggtcg cggtgaccgt
     8401 gacccggtcc cccgtccccg aggggttggg tgtggagacc acggtggtgg aggtcgcgga
     8461 ccgggtgacg gtctgggtgt cactgccggt ggagcctgtg aagccggcgt ccccgccata
     8521 ggtggccgtg acggtgaacg ggcttccggt ggtggtcgtg taggcgtggg tgacggtcgc
     8581 gacaccgccg gagagggtgc cggtggcggt gccggtgccg tcaccgaagc tgaaggtgac
     8641 cgtaccggtc ggcgtaccgg ccggggacga gacggtcgcc cggatggtca ccgtcccacc
     8701 ggacgccgag ggatcgggag ttgaggtcac cgtagtggtg gacacgttct tgctcagcgt
     8761 ttgggtgtcg gtgccggtgg aggccgagaa ggtggcgtcc ccgttgtagg tggccgtgag
     8821 ggggaacggg ctgccggacc tgctggcgta ggtgtgggtg acggtcgcga tgccgccgga
     8881 gagcgtggcg gtaccggcgc tggtgccgtc accgaagccg aaggtgaccg taccggtggg
     8941 agtaccggcc cccggcaccg tcgaggcaac cgtcgcggtc agcgtcaccg cctgcccggc
     9001 caccgacgga tccggcgacg acaccagctc cgtggtcgtc gccaccttcc ccacggtctg
     9061 cgtgtcactg ccactcgacg cggtgaagtt gccgtccccg ttgtagatcg ccgtgacggc
     9121 gtacgggctg acggaggcgc cgttgaacgt atgcgtcacg gtcgcggtgc cgttggagag
     9181 aggtttggtg gcggcgctgg tgccgtcacc gaagctgaag gtgaccgtac cggtgggagt
     9241 acccgccccc ggcgccaccg cggaaaccgt cgcggtcagc gtcaccgcct gcccggccac
     9301 cgacggatcc ggcgacgaca ccagctccgt ggtcgtcgcc gccctgccca ccgtctggct
     9361 gtcactgccg ctcgacgcgg tgaagccgct gtccccgttg taggtggcgg tgaggtggaa
     9421 ggggctgccg gacctggtgg cataggtgtg ggtgacggtc gcgatgccgt cggtgagcgt
     9481 tgtggtggtg gaaccggtgc cgtcgccgaa ggtgaaggtg accgtgccgg tggggacggc
     9541 ggcaccaggc gtggcggagg cgacggaggc cgtgagggtg gtgggctgac cgacgaccgt
     9601 gggatcgggc gaggaggcca ccgccgtggt cgtcgccgcc ttgccgacgc tctgggtgtc
     9661 gtgcccgctg gaggaggtga agttggcatc gccgccatac gtcccggtga tgacgaacgg
     9721 actgcccgag gtgccgctgt aggcatgcgt gacgactgcc cgaccatcac tcaccggcgc
     9781 cgtcaacgtc ggactgccat caccgaaatc aaacgtcacc gtccccgacg gcgcccccgc
     9841 ccccggcgca atcgacgcca ccgaagccgt caccgtcgtc aactgcccca ccaccgtggg
     9901 atcaggagaa gacaccaccc ccgtcgacgt cgccgcctta cccaccgtct gggtatcgcc
     9961 cccgctggag gaggtgaagt tggcatcgcc gccatacgtc ccggtgatga cgaacggact
    10021 gcccgacgta ccgccgtacg catgggtcac gaccgccaga ccatcactca ccggcgccgt
    10081 caacgtcgga ctgccatcac cgaaatcaaa cgtcaccgtc cccgacggcg cccccgcccc
    10141 cggcgcaacc gacgccaccg aagccgtcac cgtcgtcaac tgccccacca ccgtgggatc
    10201 aggagaagac accaccgccg tcgacgtcgc cgccctaccc accgtctggc tgtcgccccc
    10261 gctcgacggc aggaagccgg cgtccccgtc atagtccgcg gtcacctggt aggggccgcc
    10321 cgcgctcgtg taggtgtgcg tgatcctggc gacgccgtcg gagagcgagg tcagggtggg
    10381 cggtgtgccg tccccgaagg tgaaggtgac cgcgccggtc ggcacccctg ctcccggtgc
    10441 cgtcggtgcc acggtcgcgg tgagggtcac cggctggccg accaccgacg ggtccggcgt
    10501 ggccgtcacc gtggtcagtg tcgacgccgg agcgaccgtc tggctgtccg tgcccgagga
    10561 ggagctgaag ttggcgtctc cgctgtagcc cgcggtcacg gtgtacgggc tgtcggccac
    10621 ggtgttgtag acgtgggtga cgccggcgat ccccccggag agcggtgccg tgacggccgc
    10681 cgttccatcg ccgaaggtga aggtgaccgt gccggtgggg acaccggcgc cgggcggggt
    10741 cggggccacg gtcgcggtga aggacaccgg ctggcccgtc accgcggggt ccggggcgga
    10801 gctcacggtc gtcgacgtgg tggcggcgct gaccgccacc gtgtggactc cggtggcggt
    10861 ggcggaggtg aagtcgtcgt caccgctgta gtcggcggtg accgtgtagg ggctgcccga
    10921 cgtgcccacg taggcgtgtg tcacggtcgc cacctcggag gtgaccggtg cggtgacggg
    10981 tgcggtgccg tcaccgaaat cgaaggtgac ggtcccggtg ggggcgcccg cgcccggggg
    11041 gactgcggag accagggcgg tgaaggtgac ctgctgtccg gccacggacg gatccgggga
    11101 ggagaacagg gagatggtgg aggttgcctg gccgacggtc tggctccggg tgccggtgga
    11161 ggggctgaag tcggcgtccc cgccgtaggc ggccgtaatg gtgtacgggc cgggggcggt
    11221 gccggtccag gtgtgcgaga cggttgccac accggcggtg accgtggcgg tgacggaggg
    11281 ggtgccgtcg ccgaagtcga aggtgaccgt accggtcggg gtaccggccc ccggcgcggc
    11341 cgcggagacc gtcgcggtga tgtccaccgg ctggcccgtc accgaggggt ccggcgagga
    11401 ggccacttcg gtggtggtcg cggccggggt gacggtctgg gtgccggtgc cggtggaggg
    11461 gctgaagtcg gcgtccccgc tgtaggcggc cgtgagggcg taggggctgc cggaggtgct
    11521 cgcccaggcg tgggagacgg tcgcggtgcc gtccgtcacg ggtgcggtga cgggcgcggt
    11581 gccgtcgccg aagtcgaagg tgaccgtacc ggtcggggta ccggcccccg gcgcggccgc
    11641 ggagaccgtc gcggtgatgt ccaccggctg gcccgtcgcc gagggatccg gcagcgagct
    11701 gaccgtcgtc gccgacaacg acggctgcac accgtggttt cgggtcccca cggaggcggt
    11761 gaagcggtcg tcgccgtcgt aggtggcgcg gaccgtgtac gggctgcccg tggcactcgt
    11821 ataggcgtgg acggcggtcg ccacaccacc ggccgcggcg acggtgaccg gcgcggtgcc
    11881 gtcgccgaag tcgaaggtca ccgtcccggt cggcgcgccg gcctccacgg cgtcggatgt
    11941 caccctcgcg aggaacatca ccggctggcc cgtgaccgag gggtccggct gtccgctgac
    12001 ggtggtgctg gtcgtggccg gggcaacggt gtgggtgtcg gttccggtgg aggggctgaa
    12061 gtcggcgtcc ccgttgtagg cggccgtgac ggtgtagggg ctgccggagg tgccgggcca
    12121 ggcgtgggtg acggtggcgg tgccgtccgt caggggtgcg gtgaggggcg gggtgccgtc
    12181 gccgaagtcg aagaggacgg tgccggtggg ggtgcctgct cctggtgcga tggtggagac
    12241 ggtcgcggtg atgtccaccg gccggcccgt gatcgagggg tccggcagcc cggtgacagt
    12301 ggtgctggtc gcggcccggg cgacggtctg cgtgccggta gcggtggacg ggaggaagcc
    12361 gctgtccccg ctgtaggcgg ccgtgacgct gtagggactg ccggacgcgc cggtccaggt
    12421 gtgggtcgtc gtggccaccc cggaggtgac cggaaccgtg gtgggtgacg tgccgtcacc
    12481 gaagtcgaag gtgaccgtgc cggtcggtgt gccgtcgcct ggcgcggcgg ccgagagggt
    12541 cgcggtgacg gtcaccggct ggccggacac cgccggttcg ggcgacgagg tgagcagcgt
    12601 cgtggacgcg gcctggccga cggcctgtgt ggtggtgccg ctggaggcgg tggagtcggt
    12661 gtccccgccg taggtggcgg tgatggtgta cgggctgcct aacgggccgg tgtaggcgtg
    12721 ctcggcggtc gccaccccgt cggtgaccgg ctgcgcgacc gggtccgtac cgtcgccgaa
    12781 gtcgaagatc accgtgccgg tcggcgcgcc gctgcccggt tccgccgcgg tgacggtcgc
    12841 cgtgaaggtg accggctgac cgacgacgga cgggtccggc gcggagctca ccgtcgtggt
    12901 cgtcgcgtcc ggcaggaccg actgcgggga cgtggccacc gagttggtga agtcgtcgct
    12961 gccgctgtag gtggcggtga
//
