MIBiG Protein Description MIBiG Cluster MiBiG Product % ID % Coverage BLAST Score E-value
AVO00810.1 May11 BGC0001661.5 PKS 70.0 99.2 668.0 6.48e-240
AAO65351.1 oxygenase_reductase-like_protein BGC0000236.5 PKS 67.0 99.6 635.0 1.02e-227
CAG14970.1 oxygenase BGC0000253.4 PKS:Type II 65.0 99.4 611.0 5.39e-218
ARK36160.1 oxidoreductase BGC0001723.5 PKS 64.0 99.4 608.0 4.39e-217
AAD13541.1 oxygenase_homolog BGC0000239.5 PKS:Type II+saccharide:hybrid/tailoring 64.0 98.2 592.0 3.25e-210
WP_040253452.1 FAD-dependent_monooxygenase BGC0001596.3 PKS:Type II aromatic 64.0 96.4 567.0 9.15e-201
BBA97255.1 putative_oxygenase BGC0002383.3 PKS 60.0 99.0 559.0 2.46e-197
AAK57530.1 PgaM BGC0000262.5 PKS:Type II+saccharide:hybrid/tailoring 62.0 100.2 568.0 4.86e-197
CCH32750.1 Bifunctional_monooxygenase-dehydratase_like_protein BGC0002070.3 PKS 61.0 96.8 543.0 1.89e-191
ALJ99850.1 FlsO3 BGC0001904.2 PKS:Type II aromatic 59.0 98.2 540.0 4.07e-190
QDG00821.1 oxygenase-reductase BGC0002028.4 PKS 61.0 98.0 550.0 4.96e-190
AAX57196.2 auricin_polyketide_oxygenase-reductase BGC0000201.5 PKS+saccharide:hybrid/tailoring 61.0 99.2 548.0 3.52e-189
AAL15585.1 Sim7 BGC0000270.5 PKS 57.0 98.6 529.0 1.3e-185
AEE65463.1 Oxygenase_reductase-like_protein BGC0000223.5 PKS:Type II 58.0 97.6 527.0 9.45e-185
QHZ32178.1 anhydrotetracycline_monooxygenase BGC0002047.2 PKS 57.0 98.0 509.0 4.91e-178
ACP19358.1 SaqM BGC0000267.5 PKS:Type II+saccharide:oligosaccharide 55.0 97.4 508.0 1.78e-177
SEG87465.1 oxygenase/bifunctional_oxygenase/reductase BGC0002712.2 PKS 56.0 103.0 508.0 5.3e-177
B9W61_07270 monooxygenase BGC0001438.5 PKS+saccharide:hybrid/tailoring 57.0 98.2 501.0 6.96e-175
AAK06789.1 putative_oxygenase_SimA8 BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 55.0 98.6 491.0 1.29e-170
CBH32087.1 putative_FAD-dependent_monooxygenase BGC0000211.5 PKS 53.0 99.0 471.0 8.59e-163
ADB02848.1 AzicO5 BGC0000202.5 PKS 53.0 97.6 465.0 4.11e-161
CBH32814.1 putative_monooxygenase BGC0000263.5 PKS 52.0 98.2 461.0 7.74e-159
ALJ99849.1 FlsO2 BGC0001904.2 PKS:Type II aromatic 51.0 98.4 449.0 3.23e-154
OWA25247.1 monooxygenase BGC0001438.5 PKS+saccharide:hybrid/tailoring 49.0 99.6 448.0 6.69e-154
ADB02837.1 AzicO3 BGC0000202.5 PKS 48.0 98.6 437.0 1.61e-149
QOP59268.1 FAD-binding_monooxygenase BGC0002504.2 PKS 50.0 99.0 437.0 1.84e-149
ACP19351.1 SaqE BGC0000267.5 PKS:Type II+saccharide:oligosaccharide 50.0 99.2 434.0 1.34e-148
ARK36153.1 oxygenase BGC0001723.5 PKS 50.0 98.2 434.0 3.16e-148
ALJ99869.1 FlsO5 BGC0001904.2 PKS:Type II aromatic 49.0 99.4 432.0 1.31e-147
ADB02842.1 AzicO4 BGC0000202.5 PKS 48.0 98.6 431.0 3.31e-147
OKI81337.1 monooxygenase BGC0002478.3 PKS 49.0 99.8 431.0 4.19e-147
UPN68079.1 putative_FAD-dependent_monooxygenase BGC0002672.2 PKS 51.0 98.6 430.0 4.87e-147
CCH32751.1 Methylmalonyl-CoA_decarboxylase,_alpha_subunit BGC0002070.3 PKS 48.0 98.4 426.0 2.63e-145
AAK57522.1 PgaE BGC0000262.5 PKS:Type II+saccharide:hybrid/tailoring 47.0 100.2 424.0 2.33e-144
CBH32810.1 putative_oxygenase BGC0000263.5 PKS 48.0 104.6 424.0 2.99e-144
AAK06782.1 putative_oxygenase_SimA7 BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 48.0 99.2 423.0 4.68e-144
AVO00807.1 May8 BGC0001661.5 PKS 50.0 99.8 423.0 5.05e-144
ADI71441.1 putative_oxygenase BGC0000203.3 PKS 48.0 99.2 422.0 1.16e-143
QDG00828.1 FAD-binding_protein BGC0002028.4 PKS 48.0 99.4 422.0 1.23e-143
SEG87429.1 bifunctional_hydroxylase/dehydrase BGC0002712.2 PKS 48.0 100.4 421.0 4.06e-143
WP_040253455.1 FAD-dependent_monooxygenase BGC0001596.3 PKS:Type II aromatic 49.0 101.0 421.0 4.33e-143
CBH32083.1 putative_FAD-dependent_monooxygenase BGC0000211.5 PKS 48.0 100.0 420.0 1.09e-142
AAO65352.1 oxygenase-like_protein BGC0000236.5 PKS 48.0 100.0 418.0 4.87e-142
AAD13534.1 oxygenase_homolog BGC0000239.5 PKS:Type II+saccharide:hybrid/tailoring 48.0 99.8 417.0 8.57e-142
AEE65462.1 oxygenase BGC0000223.5 PKS:Type II 47.0 98.2 414.0 1.46e-140
BBA97256.1 putative_oxygenase BGC0002383.3 PKS 47.0 102.0 414.0 2.9e-140
CAG14963.1 oxygenase BGC0000253.4 PKS:Type II 49.0 98.2 413.0 4.31e-140
POM23760.1 Pentachlorophenol_4-monooxygenase BGC0002369.2 PKS 48.0 99.4 412.0 5.54e-140
ADI71448.1 putative_oxygenase-reductase BGC0000203.3 PKS 56.0 83.7 416.0 2.54e-139
TRO56982.1 SDR_family_oxidoreductase BGC0002361.3 PKS+saccharide 59.0 74.3 417.0 2.63e-139
OKI59864.1 monooxygenase BGC0002477.3 PKS 48.0 100.0 411.0 2.97e-139
EHM27503.1 monooxygenase_FAD-binding BGC0000235.5 PKS 48.0 100.0 410.0 8.41e-139
AEE65484.1 monooxygenase BGC0000223.5 PKS:Type II 48.0 98.8 409.0 2.03e-138
AEE65473.1 oxygenase-like_protein BGC0000223.5 PKS:Type II 49.0 100.2 409.0 2.09e-138
AAX57188.2 auricin_polyketide_oxiygenase BGC0000201.5 PKS+saccharide:hybrid/tailoring 48.0 99.0 408.0 2.29e-138
BAV16997.1 putative_oxygenase BGC0001384.5 PKS 47.0 99.4 405.0 3.26e-137
MBW8699681.1 Anhydrotetracycline_monooxygenase BGC0002140.2 PKS 47.0 100.0 405.0 4.19e-137
TRO56975.1 monooxygenase BGC0002361.3 PKS+saccharide 47.0 99.2 405.0 6.32e-137
CAH10119.1 putative_oxygenase BGC0000268.5 PKS 46.0 99.2 402.0 7.17e-136
QHZ32179.1 anhydrotetracycline_monooxygenase BGC0002047.2 PKS 47.0 98.6 401.0 1.91e-135
OKI81344.1 monooxygenase BGC0002478.3 PKS 55.0 83.9 407.0 2.15e-135
ABP54650.1 monooxygenase,_FAD-binding BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 46.0 99.2 399.0 1.08e-134
POM23767.1 Pentachlorophenol_4-monooxygenase BGC0002369.2 PKS 58.0 73.7 394.0 3.24e-134
ARO44651.1 monooxygenase BGC0001769.5 PKS 47.0 100.0 398.0 3.36e-134
AHZ61861.1 Lom27 BGC0000240.5 PKS:Type II+saccharide:hybrid/tailoring 46.0 99.2 395.0 2.45e-133
BAJ07846.1 putative_oxygenase-reductase BGC0000232.5 PKS 50.0 96.0 401.0 4.01e-133
BAJ07857.1 putative_oxygenase BGC0000232.5 PKS 48.0 93.0 392.0 1.4e-132
AGO50609.1 oxidoreductase BGC0000229.5 PKS:Type II+saccharide:hybrid/tailoring 46.0 99.4 394.0 1.53e-132
ARD70874.1 FAD-binding_monooxygenase BGC0001693.3 PKS 49.0 97.2 392.0 2.51e-132
ARD70872.1 FAD-binding_monooxygenase BGC0001693.3 PKS 47.0 99.6 393.0 2.78e-132
EHM27510.1 monooxygenase_FAD-binding BGC0000235.5 PKS 53.0 83.5 395.0 7.09e-131
ARD70875.1 FAD-binding_monooxygenase BGC0001693.3 PKS 46.0 99.0 389.0 8.9e-131
ALJ99859.1 FlsO1 BGC0001904.2 PKS:Type II aromatic 46.0 99.8 388.0 2.95e-130
OKI59857.1 monooxygenase BGC0002477.3 PKS 52.0 83.5 393.0 3.98e-130
AHZ61858.1 Lom24 BGC0000240.5 PKS:Type II+saccharide:hybrid/tailoring 47.0 98.8 385.0 2.85e-129
ABP54647.1 monooxygenase,_FAD-binding BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 47.0 98.8 381.0 1.82e-127
BAV17004.1 putative_oxygenase-reductase BGC0001384.5 PKS 53.0 85.1 385.0 3.29e-127
AGO50615.1 oxygenase-reductase BGC0000229.5 PKS:Type II+saccharide:hybrid/tailoring 51.0 85.1 384.0 9.23e-127
AHZ61860.1 Lom26 BGC0000240.5 PKS:Type II+saccharide:hybrid/tailoring 47.0 96.4 377.0 1.93e-126
ABP54649.1 monooxygenase,_FAD-binding BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 46.0 97.2 374.0 6.17e-125
QOP59275.1 oxidoreductase BGC0002504.2 PKS 47.0 99.0 374.0 6.57e-125
ARO44645.1 monooxygenase BGC0001769.5 PKS 54.0 77.5 377.0 4.92e-124
MBW8699688.1 Anhydrotetracycline_monooxygenase BGC0002140.2 PKS 54.0 77.5 375.0 2.75e-123
ALJ99864.1 FlsO4 BGC0001904.2 PKS:Type II aromatic 43.0 99.2 370.0 3.36e-123
POM23774.1 Pentachlorophenol_4-monooxygenase BGC0002369.2 PKS 44.0 98.6 366.0 1.41e-121
ARD70864.1 FAD-binding_monooxygenase BGC0001693.3 PKS 45.0 98.8 364.0 3.88e-121
UPN68086.1 putative_SDR_family_oxidoreductase BGC0002672.2 PKS 52.0 83.7 368.0 9.18e-121
AAO65343.1 oxygenase-like_protein BGC0000236.5 PKS 43.0 99.0 362.0 1.93e-120
AHZ61850.1 Lom16 BGC0000240.5 PKS:Type II+saccharide:hybrid/tailoring 45.0 98.4 362.0 2.63e-120
WP_040253436.1 FAD-dependent_monooxygenase BGC0001596.3 PKS:Type II aromatic 43.0 98.2 357.0 3.46e-118
ABP54639.1 monooxygenase,_FAD-binding BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 44.0 98.6 356.0 7.52e-118
QSV12648.1 AvmO2 BGC0002456.3 PKS+NRPS:Type I 44.0 105.0 353.0 1.48e-116
AEE65478.1 putative_oxygenase BGC0000223.5 PKS:Type II 43.0 98.6 352.0 3.29e-116
AKJ15842.1 hypothetical_protein BGC0002735.2 PKS+NRPS:Type I 42.0 101.4 347.0 1.88e-114
ACN64854.1 PokO4 BGC0001061.4 PKS:Type II aromatic 45.0 102.8 345.0 1.3e-113
AKD43495.1 Monooxygenase BGC0001409.5 PKS 44.0 102.6 343.0 1.06e-112
AHZ61851.1 Lom17 BGC0000240.5 PKS:Type II+saccharide:hybrid/tailoring 43.0 99.2 342.0 2.54e-112
AGZ15446.1 putative_polyketide_oxygenase/hydroxylase BGC0001036.5 NRPS:Type I+PKS 42.0 101.6 344.0 3.02e-112
AAG30198.1 oxygenase BGC0000261.5 PKS 42.0 100.8 341.0 9.91e-112
ABP54640.1 monooxygenase,_FAD-binding BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 43.0 99.4 340.0 1.01e-111
ARD70865.1 FAD-binding_monooxygenase BGC0001693.3 PKS 42.0 97.6 328.0 2.79e-107
AAZ77700.1 ChlE3 BGC0000036.5 PKS:Type I+saccharide:oligosaccharide 41.0 99.6 325.0 6.27e-106
CAE17536.1 oxygenase BGC0000210.5 PKS:Type II+saccharide:oligosaccharide 44.0 103.2 325.0 1.58e-105
AFU65887.1 DacO3 BGC0000216.5 PKS 42.0 96.2 320.0 7.12e-104
WP_051729299.1 FAD-dependent_monooxygenase BGC0002137.3 PKS 42.0 99.6 320.0 1.31e-103
AAZ78342.1 OxyS BGC0000254.5 PKS 41.0 102.4 319.0 2.53e-103
AAZ77692.1 ChlE1 BGC0000036.5 PKS:Type I+saccharide:oligosaccharide 39.0 104.0 313.0 4.52e-101
BAQ25484.1 FAD-dependent_oxidoreductase BGC0001288.5 PKS 42.0 100.8 312.0 8.48e-101
ACB46484.1 FAD-dependent_oxidoreductase BGC0000082.5 PKS 42.0 99.4 311.0 1.68e-100
AAP69582.1 putative_FAD-dependent_oxygenase BGC0000226.5 PKS 38.0 99.4 311.0 2.24e-100
CAK50794.2 oxygenase BGC0000247.5 PKS:Type II+saccharide:oligosaccharide 42.0 101.6 311.0 5.74e-100
QSV12647.1 AvmO1 BGC0002456.3 PKS+NRPS:Type I 39.0 102.6 305.0 8.09e-98
ACY06308.1 FAD-dependent_monooxygenase BGC0001042.5 NRPS:Type I+PKS 42.0 102.0 301.0 1.46e-96
AAM97364.1 RubN BGC0000266.5 PKS 41.0 100.0 301.0 1.99e-96
ACR50781.1 putative_FAD-dependent_oxygenase BGC0000163.5 PKS 39.0 102.8 300.0 3.36e-96
ADE34499.1 SsfO1 BGC0000269.5 PKS:Type II+saccharide:hybrid/tailoring 39.0 104.4 300.0 4.99e-96
BBA97264.1 putative_monooxygenase BGC0002383.3 PKS 39.0 103.6 300.0 8.37e-96
AFU65892.1 DacO1 BGC0000216.5 PKS 40.0 101.4 299.0 1.12e-95
AGC09488.1 LobA BGC0001183.5 PKS 38.0 101.0 288.0 1.11e-91
AGI99493.1 FAD-dependent_oxidoreductase BGC0001004.5 PKS:Type I 38.0 100.6 287.0 3.09e-91
QFU80897.1 FAD-dependent_oxidoreductase BGC0002550.2 PKS 38.0 100.6 287.0 3.09e-91
QSV12649.1 AvmO3 BGC0002456.3 PKS+NRPS:Type I 39.0 108.6 284.0 2.1e-89
ACB37744.1 FAD-dependent_oxygenase BGC0000162.5 PKS 40.0 100.4 280.0 1.42e-88
AAY28223.1 HbmL BGC0000074.5 PKS 39.0 97.8 280.0 3.41e-88
AEI98657.1 CtcN BGC0000209.5 PKS 39.0 101.0 278.0 1.51e-87
AAO06914.1 GdmL BGC0000066.5 PKS 37.0 99.6 276.0 5.25e-87
CAH10112.1 putative_oxidase-reducatse BGC0000268.5 PKS 46.0 76.9 280.0 5.67e-87
QVQ68811.1 mmyOIV BGC0002129.4 PKS 44.0 85.5 274.0 7.37e-87
BAQ21949.1 putative_FAD-dependent_oxidoreductase BGC0001204.5 PKS 37.0 104.2 271.0 1.34e-84
AOZ61203.1 oxygenase BGC0001762.3 other:other 38.0 105.0 271.0 1.49e-84
QNL10605.1 FAD-dependent_oxidoreductase BGC0002514.3 PKS 38.0 102.6 270.0 1.77e-84
QKG20158.1 cyclohexane_4+2_cyclase BGC0002124.3 PKS:Type I 38.0 98.0 268.0 5.79e-84
ABI22123.1 monooxygenase BGC0000422.5 NRPS:Type I 38.0 101.8 266.0 6.83e-83
WP_020275087.1 FAD-dependent_oxidoreductase BGC0002012.4 PKS 38.0 101.4 265.0 7.53e-83
BAE93724.1 putative_FAD-dependent_monooxygenase BGC0000164.5 PKS 37.0 102.8 258.0 7.03e-80
ARG41919.1 IstP BGC0001622.5 PKS 36.0 102.2 256.0 2.91e-78
SEG87398.1 2-polyprenyl-6-methoxyphenol_hydroxylase BGC0002712.2 PKS 39.0 102.6 254.0 3.68e-78
AGD80608.1 monooxygenase BGC0000394.5 NRPS:Type I 37.0 102.8 247.0 7.7e-76
ctg1_orf39 BGC0001013.5 NRPS:Type I+PKS 38.0 104.6 246.0 3.95e-75
ABO15838.1 FAD-dependent_monooxygenase BGC0000130.5 PKS 37.0 100.2 228.0 3.37e-68
AAG30200.1 oxygenase BGC0000261.5 PKS 35.0 105.2 224.0 6.27e-67
ABC87527.1 FAD-dependent_monooxygenase BGC0001011.5 NRPS:Type I+PKS 37.0 98.6 220.0 8.92e-66
AZY91999.1 spiro_cyclase BGC0002022.4 PKS 34.0 101.8 216.0 4.53e-64
CAG14971.1 oxygenase BGC0000253.4 PKS:Type II 36.0 102.0 215.0 2.12e-63
ARK36161.1 hypothetical_protein BGC0001723.5 PKS 36.0 102.0 215.0 2.12e-63
AAP69585.1 putative_FAD-dependent_oxygenase BGC0000226.5 PKS 39.0 76.3 205.0 2.57e-60
AKD43496.1 Monooxygenase BGC0001409.5 PKS 32.0 103.6 172.0 2.38e-47
AGI62225.1 AbeX1-like_monooxygenase BGC0001335.5 other:other 32.0 110.8 163.0 6.5e-44
BBM95966.1 monooxygenase BGC0002558.2 PKS 30.0 100.2 160.0 3.81e-43
ACN64853.1 PokO2 BGC0001061.4 PKS:Type II aromatic 31.0 107.2 159.0 1.3e-42
AKQ99277.1 pentachlorophenol_4-monooxygenase BGC0001484.3 other:other 35.0 70.5 150.0 5.79e-40
ARS01465.1 NcmL BGC0001702.3 NRPS:Type I+PKS 30.0 100.0 146.0 4.21e-38
AEF32090.1 monooxygenase BGC0001333.5 other:other 30.0 106.0 145.0 1.96e-37
AEO12714.1 flavin_monooxygenase BGC0001334.5 other:other 35.0 72.7 142.0 1.6e-36
AXO35174.1 hypothetical_protein BGC0001848.4 other:other 31.0 105.6 140.0 8.24e-36
AKQ20687.1 monooxygenase BGC0001337.5 other:other 33.0 70.7 138.0 1.07e-35
QXL90822.1 FAD-binding_monooxygenase BGC0002426.3 NRPS:Type I 31.0 106.8 139.0 3.09e-35
EWM63062.1 FAD-binding_monooxygenase BGC0000679.5 terpene 31.0 105.2 139.0 3.39e-35
QXL90824.1 FAD-dependent_monooxygenase BGC0002426.3 NRPS:Type I 31.0 109.0 137.0 8.15e-35
QUJ09171.1 Lon24 BGC0002440.3 NRPS:Type I 31.0 70.1 133.0 2.63e-33
AAM97362.1 RubL BGC0000266.5 PKS 30.0 104.2 132.0 6.78e-33
BAJ52699.1 putative_FAD-binding_monooxygenase BGC0000222.5 PKS 30.0 98.0 130.0 2.51e-32
ADQ55479.1 FAD-binding_monooxygenase BGC0000350.5 NRPS:Type I 27.0 76.7 128.0 8.34e-32
AKG47162.1 HysC BGC0001223.5 other:other 27.0 107.8 128.0 1.19e-31
ABB88524.1 Baeyer-Villiger_monooxygenase BGC0000050.5 PKS 30.0 82.5 125.0 7.7e-31
AUI41038.1 FAD-dependent_monooxygenase BGC0001512.5 PKS 32.0 71.3 124.0 2.85e-30
ABX71099.1 Lct16 BGC0000238.5 PKS 32.0 68.3 122.0 8.53e-30
AHX24715.1 FAD-binding_monooxygenase BGC0000200.5 PKS:Type II+saccharide:hybrid/tailoring 27.0 102.6 114.0 6.01e-27
RLV71184.1 2-polyprenyl-6-methoxyphenol_hydroxylase-like_oxidoreductase BGC0001846.4 saccharide:hybrid/tailoring+NRPS:Type I 29.0 113.5 114.0 1.16e-26
ADE22302.1 putative_FAD-binding_monooxygenase BGC0000279.5 PKS 27.0 107.4 113.0 2.02e-26
CAI94716.1 putative_hydroxyphenylpropionate BGC0000141.5 PKS 28.0 102.6 112.0 4.34e-26
QIE07117.1 OvmE BGC0001719.4 PKS 30.0 102.2 108.0 4.83e-25
CCP20041.1 divE_protein BGC0001119.5 PKS:Type I 30.0 102.2 108.0 6.29e-25
QBL56159.1 monooxygenase BGC0002376.2 PKS 29.0 68.5 106.0 3.9e-24
QES95468.1 3-(3-hydroxyphenyl)propionate_hydroxylase BGC0002453.2 PKS 29.0 73.3 102.0 5.86e-23
EAU38788.1 conserved_hypothetical_protein BGC0000161.4 PKS:Iterative type I 27.0 69.9 100.0 4.3e-22
CAO91863.1 putative_monooxygenase BGC0000968.5 NRPS:Type I+PKS:Iterative type I 28.0 72.5 95.0 2.26e-20
ESK96612.1 phenol_2-monooxygenase BGC0002212.3 PKS 23.0 75.7 78.0 9.31e-15
AYU66242.1 TjhO2 BGC0002461.2 PKS 26.0 82.7 75.0 6.19e-14
QIS94334.1 Tjp8 BGC0002482.2 other:other 29.0 33.5 71.0 3.24e-13
AAZ78329.1 OxyE BGC0000254.5 PKS 27.0 63.7 60.0 2.42e-09
CAK50781.1 oxygenase BGC0000247.5 PKS:Type II+saccharide:oligosaccharide 27.0 66.5 60.0 2.54e-09
QIQ28654.1 Nbc58 BGC0002541.2 other:other 26.0 68.5 60.0 3.09e-09
QIQ28598.1 Nbc2 BGC0002541.2 other:other 28.0 65.9 54.0 2.07e-07
ALJ99865.1 FlsP BGC0001904.2 PKS:Type II aromatic 26.0 64.1 53.0 3.79e-07
WP_091316344.1 NAD(P)/FAD-dependent_oxidoreductase BGC0002007.2 terpene 26.0 64.1 52.0 9.22e-07