LOCUS       NZ_CP114899            21699 bp    DNA     circular CON 18-FEB-2024
DEFINITION  Bacillus subtilis strain 1 chromosome, complete genome.
ACCESSION   NZ_CP114899
VERSION     NZ_CP114899.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4214774)
  AUTHORS   Li,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-DEC-2022) College of Veterinary Medicine, Huazhong
            Agricultural University, Shizi street, Wuhan, Hubei 430000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v1.5 v. Hifiasm v0.12-r304
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/18/2024 04:35:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,515
            CDSs (total)                      :: 4,397
            Genes (coding)                    :: 4,195
            CDSs (with protein)               :: 4,195
            Genes (RNA)                       :: 118
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 202
            CDSs (without protein)            :: 202
            Pseudo Genes (ambiguous residues) :: 0 of 202
            Pseudo Genes (frameshifted)       :: 128 of 202
            Pseudo Genes (incomplete)         :: 67 of 202
            Pseudo Genes (internal stop)      :: 46 of 202
            Pseudo Genes (multiple problems)  :: 34 of 202
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:13:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3364119
            Orig. end                         :: 3385818
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP114899.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21699
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="epipeptide"
                     /region_number="8"
                     /rules="(TIGR04078 and yydH)"
                     /tool="antismash"
     cand_cluster    1..21699
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04078 and yydH)"
                     /kind="single"
                     /product="epipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21699
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11699](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04078 and yydH)"
                     /neighbourhood="10000"
                     /product="epipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11699
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04078 and yydH)"
                     /neighbourhood="10000"
                     /product="epipeptide"
                     /protocluster_number="1"
     misc_feature    3340..3351
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     misc_feature    3556..3576
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.32"
                     /tool="antismash"
     misc_feature    3902..3915
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.88"
                     /tool="antismash"
     misc_feature    4252..4266
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.43"
                     /tool="antismash"
     misc_feature    complement(4269..4283)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.75"
                     /tool="antismash"
     gene            4592..6373
                     /locus_tag="O6U12_RS17920"
                     /old_locus_tag="O6U12_17920"
     CDS             4592..6373
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017697254.1"
                     /locus_tag="O6U12_RS17920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17920"
                     /product="DUF262 domain-containing protein"
                     /protein_id="WP_029726127.1"
                     /transl_table=11
                     /translation="MKTKLTAQETPLHKVFSDDYLFTVPSVQRPYSWTTDEARELLDDL
                     LEFINHYGITENNVSKVDEPYFLGSIVLVKKDGPKSEVLDGQQRLTTLTILFSVLRDIL
                     SADYADDIEQMVVQKGSKILGTKDTYRLHLRKRDDEFLKKYIQEKGMTHKVTKDTPYKT
                     DSQKAIRDNAMYFMERLNELDEDTVKTLPLVLATLCFIVVVSTPSFDSAFRIFTVLNDR
                     GLDLLPSDIFKARVIGAISENEQDFYTNKWEDVEVSLGRDRFNKLFDHIRMIIQKRKGS
                     ANYKDEYEDIFSKVTGKEFIDNILIPYSEIYLKLLDYRSYYSHQPKIIKVLSLLNRIDN
                     NDWIPVAMFYIQGYSEKLEEFLNLLEQFAGISMVLRKNFNWRMSKYSQILRQMEKRVDV
                     FSEESLLKVSDEDKRAVLEKLNGDVYTELKDTVRRYVLLRLDSLLTNGQPFYDHSVITV
                     EHVLPQTPKEGSDWLANFADPSEYVHKLGNLVLLTRSKNSQARNYDFNKKKTLYFQPKN
                     GVTTFALTTQVVQEKEWTPTVLEERQKKLINLLRHAWDLNVKYNSTTPNKEDKNNNSNE
                     SHLNKKYFSNRFYIRYD"
     gene            6366..6425
                     /locus_tag="O6U12_RS17925"
                     /old_locus_tag="O6U12_17925"
     CDS             6366..6425
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024682.4"
                     /locus_tag="O6U12_RS17925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17925"
                     /product="hypothetical protein"
                     /protein_id="WP_085961365.1"
                     /transl_table=11
                     /translation="MTDGYAVNLHQELIGVKLP"
     gene            6446..7135
                     /locus_tag="O6U12_RS17930"
                     /old_locus_tag="O6U12_17930"
     CDS             6446..7135
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012958842.1"
                     /locus_tag="O6U12_RS17930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17930"
                     /product="hypothetical protein"
                     /protein_id="WP_017697255.1"
                     /transl_table=11
                     /translation="MSNFDISIKKRLILLLGQNSETLKVVETLSTTGNLLFFGGSIRDL
                     CMAPEVNKMPRDFDIAINFKNEEKFSALIGNYNYKKNRFGGYKFSISNIDFDVWDLNNT
                     WAFKNKHLKPSKENLAKSVYLNIDGIVYNFNEGLLYDDVFRSSIQNSKLDITLEENPEI
                     ELNLLRAIIFKYKYNLNFSEKLKNVFKTFMNIQEENLIENLYQIQIAHYKATSFSKEEI
                     RKELQCI"
     gene            complement(7397..9322)
                     /gene="fbp"
                     /locus_tag="O6U12_RS17935"
                     /old_locus_tag="O6U12_17935"
     CDS             complement(7397..9322)
                     /codon_start=1
                     /gene="fbp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391899.2"
                     /locus_tag="O6U12_RS17935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17935"
                     /product="fructose-1,6-bisphosphatase"
                     /protein_id="WP_017697256.1"
                     /transl_table=11
                     /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLHG
                     EYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAKAA
                     LNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQYYSE
                     IIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHSVDIQ
                     WGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYYDDNPA
                     FRPKADDNRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKIDYDKNE
                     ITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMNFMMKKGS
                     LYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFAHPEETDDL
                     ATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDEATCRNILAE
                     FGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGIAGYTLLYNSY
                     GMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEELLQEVAILESLR
                     EYRYMK"
     gene            9794..9943
                     /gene="liaD"
                     /locus_tag="O6U12_RS17940"
                     /old_locus_tag="O6U12_17940"
     CDS             9794..9943
                     /codon_start=1
                     /gene="liaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614717.1"
                     /locus_tag="O6U12_RS17940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17940"
                     /product="epipeptide YydF family RiPP"
                     /protein_id="WP_014478520.1"
                     /transl_table=11
                     /translation="MKKENTNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWIL
                     GSGH"
     misc_feature    9999..10017
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 25.45"
                     /tool="antismash"
     gene            10001..10960
                     /gene="liaE"
                     /locus_tag="O6U12_RS17945"
                     /old_locus_tag="O6U12_17945"
     CDS             10001..10960
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="liaE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     epipeptide: TIGR04078"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391897.1"
                     /locus_tag="O6U12_RS17945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17945"
                     /product="YydG family radical SAM peptide epimerase"
                     /protein_id="WP_003242609.1"
                     /sec_met_domain="TIGR04078 (E-value: 6e-173, bitscore:
                     572.4, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.6e-08, bitscore: 30.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 8.2e-06, bitscore: 23.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9.2e-11, bitscore: 40.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTEF
                     AKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFHDM
                     NSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHILEEL
                     GDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGEIYPC
                     CSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKIEEFDI
                     PYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV"
     gene            10941..11699
                     /gene="liaK"
                     /gene_synonym="yydH"
                     /locus_tag="O6U12_RS17950"
                     /old_locus_tag="O6U12_17950"
     CDS             10941..11699
                     /codon_start=1
                     /gene="liaK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     epipeptide: yydH"
                     /gene_kind="biosynthetic"
                     /gene_synonym="yydH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391896.2"
                     /locus_tag="O6U12_RS17950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17950"
                     /product="zinc metalloprotease LiaK"
                     /protein_id="WP_017697257.1"
                     /sec_met_domain="yydH (E-value: 3.5e-153, bitscore: 508.1,
                     seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDEQLLRF
                     KMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMNIV
                     LHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLFINY
                     FLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEYSRFK
                     TNHWLVLTIQIIGIGLAVNSVVHWILYIVN"
     gene            11849..12478
                     /gene="liaL"
                     /locus_tag="O6U12_RS17955"
                     /old_locus_tag="O6U12_17955"
     CDS             11849..12478
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="liaL"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391895.1"
                     /locus_tag="O6U12_RS17955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17955"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_014481448.1"
                     /transl_table=11
                     /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAKD
                     FLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAEMIDKIAHLLNLDN
                     IDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYIQEN
                     PEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE"
     gene            12499..13221
                     /gene="liaM"
                     /locus_tag="O6U12_RS17960"
                     /old_locus_tag="O6U12_17960"
     CDS             12499..13221
                     /codon_start=1
                     /gene="liaM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391894.1"
                     /locus_tag="O6U12_RS17960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17960"
                     /product="peptide ABC transporter permease"
                     /protein_id="WP_014478516.1"
                     /transl_table=11
                     /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPEM
                     FFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFLEC
                     FAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISMLCPNILISIGVSIVY
                     WMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLVSIII
                     INAIILRFSKTRWIKMGI"
     gene            complement(13352..13510)
                     /locus_tag="O6U12_RS17965"
                     /old_locus_tag="O6U12_17965"
     CDS             complement(13352..13510)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097799.1"
                     /locus_tag="O6U12_RS17965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17965"
                     /product="hypothetical protein"
                     /protein_id="WP_017697258.1"
                     /transl_table=11
                     /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFTIFFLFV
                     KLVKEKQ"
     gene            complement(13538..14248)
                     /gene="yydK"
                     /locus_tag="O6U12_RS17970"
                     /old_locus_tag="O6U12_17970"
     CDS             complement(13538..14248)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="yydK"
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391893.1"
                     /locus_tag="O6U12_RS17970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17970"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_017697259.1"
                     /transl_table=11
                     /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTITK
                     SLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVRKP
                     TPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSTFHYIR
                     EGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKISYNY
                     EQSQFVVQANSFLL"
     gene            14406..>14486
                     /locus_tag="O6U12_RS17975"
                     /old_locus_tag="O6U12_17975"
                     /pseudo=""
     CDS             14406..>14486
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012587.4"
                     /locus_tag="O6U12_RS17975"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17975"
                     /product="PTS beta-glucoside transporter subunit IIBCA"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGKVRDYTRLAKDILEAVGGEENVIG"
     gene            <14584..14823
                     /gene="ptsJ"
                     /locus_tag="O6U12_RS17980"
                     /old_locus_tag="O6U12_17980"
                     /pseudo=""
     CDS             <14584..14823
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene="ptsJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003236458.1"
                     /locus_tag="O6U12_RS17980"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17980"
                     /product="PTS glucose transporter subunit IIA"
                     /pseudo=""
                     /transl_table=11
                     /translation="TVVMVTPTKHAIGLRSASGVELLAHIGLDTVTLGGTPFSLKVKEG
                     DTVKKGEVLVEFDKAFIEEIEESALHQKIFTVVS"
     gene            14837..16276
                     /gene="bglA"
                     /locus_tag="O6U12_RS17985"
                     /old_locus_tag="O6U12_17985"
     CDS             14837..16276
                     /EC_number="3.2.1.86"
                     /codon_start=1
                     /gene="bglA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391891.1"
                     /locus_tag="O6U12_RS17985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17985"
                     /product="6-phospho-beta-glucosidase BglA"
                     /protein_id="WP_017697261.1"
                     /transl_table=11
                     /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVPR
                     KITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEPNE
                     AGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEACFTR
                     YKEKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVASALAV
                     AKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYPSYALK
                     EFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGGLPNGVE
                     NPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKVHDPERIQ
                     YLKSHIEALEKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRDNEGNGSMK
                     RYKKDSFEWYKNVIQTNGEEL"
     gene            complement(16372..17901)
                     /gene="ahpF"
                     /locus_tag="O6U12_RS17990"
                     /old_locus_tag="O6U12_17990"
     CDS             complement(16372..17901)
                     /GO_function="GO:0016668 - oxidoreductase activity, acting
                     on a sulfur group of donors, NAD(P) as acceptor [Evidence
                     IEA]"
                     /GO_process="GO:0006805 - xenobiotic metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009398 - FMN biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ahpF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391890.1"
                     /locus_tag="O6U12_RS17990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17990"
                     /product="alkyl hydroperoxide reductase subunit F"
                     /protein_id="WP_017697262.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6.6e-45, bitscore:
                     151.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDISKDMLALVDELA
                     SMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPKVD
                     QKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKAEVE
                     SKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGADASEFADKEPFDVLVVGGGPAGAS
                     AAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEYDIDVM
                     NLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGVAYCPHC
                     DGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRLYSLPNVT
                     VVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLEGTVERNRM
                     GEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIRN"
     gene            complement(17915..18478)
                     /gene="ahpC"
                     /locus_tag="O6U12_RS17995"
                     /old_locus_tag="O6U12_17995"
     CDS             complement(17915..18478)
                     /EC_number="1.11.1.26"
                     /GO_function="GO:0102039 - NADH-dependent peroxiredoxin
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ahpC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391889.1"
                     /locus_tag="O6U12_RS17995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_17995"
                     /product="alkyl hydroperoxide reductase subunit C"
                     /protein_id="WP_015483942.1"
                     /transl_table=11
                     /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFSF
                     VCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKIGKITYAMIGDPSQTI
                     SRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQNPG
                     EVCPAKWEEGGETLTPSLDLVGKI"
     misc_feature    18660..18674
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 23.04"
                     /tool="antismash"
     gene            complement(18952..20358)
                     /gene="gnd"
                     /locus_tag="O6U12_RS18000"
                     /old_locus_tag="O6U12_18000"
     CDS             complement(18952..20358)
                     /EC_number="1.1.1.44"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="gnd"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391888.1"
                     /locus_tag="O6U12_RS18000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O6U12_18000"
                     /product="decarboxylating NADP(+)-dependent
                     phosphogluconate dehydrogenase"
                     /protein_id="WP_017697263.1"
                     /transl_table=11
                     /translation="MFNTIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLVQKL
                     DGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNSHY
                     EDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAAQVG
                     DDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFETWNQ
                     GELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPSTIITE
                     SLFARYLSSLKEERMAAQDVLAGPESEEKHLDKDTWIEYVRQALYMGKVCAYAQGFAQY
                     KMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPYFTDKLHA
                     YQTGLRKIVCEGISTGIAFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDM
                     DGVFHTNWSE"
     misc_feature    20598..20612
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 17.93"
                     /tool="antismash"
     misc_feature    20898..20912
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
ORIGIN
        1 aaacccagaa atattattta ataaaatggc tcgaaaatct gatggtgaat ggtttcgtga
       61 taaagattta catagattcc tgactttaaa tggaattaag aagaaagatt ttaatggtcg
      121 tgctgatgag tggttctatt ttaatggaac accagaaaag gctgaagagc taacagataa
      181 gtttattaat cttgattatg atgagagtca aattgatgat agaaattcaa gctatgtttt
      241 acgaaatgaa caacagcaag ctgttgagaa aacgtatgag tattttcaaa gtgatcaaga
      301 accaagagaa ttcttgtgga atgcaaaacc tcgttttgga aaaactttaa caacttatga
      361 ttttataaga aacttaaaag caaccaatgt tttaatagta actaatagac ctgcgattgc
      421 caattcatgg tttgacgatt tccaaaaatt cattgcatgg caagagccac atatgaaatt
      481 cgtttcagaa acggaagcat tgaatggaaa agctatgact agaaaacagt atttagacta
      541 tctggataat acctcttatc ctaatccctc gcaaattact tttatatcct tacaagactt
      601 aaaaggagca aagtttgctg ggggcagtta tgaaaagtta gaatgggttg ctggattaaa
      661 ttgggatttg ttagttattg atgaagccca tgaaggaatt gatacgaaaa agacagatat
      721 agcatttagc caaataaaga gagactttac attgcattta tctggtactc cctttaaggc
      781 attggctaat aataaatttt ccgaagagca aatatttaat tggtcgtatg tggatgaaca
      841 agaagcaaaa gaaaaatggg atccaacaat aagtagtaac ccttatgaaa gcttgccaac
      901 tttaaatctg tttacttatc aaatgagtaa aatggtagaa gcagaagtgt ctgaagggat
      961 gacattagaa gaggagaaaa acgttgatta tgcttttgat ttaaatgaat tttttagagt
     1021 gaaggaaaat gggaactttg aatacgaaga aagtgtcaac cgatttttag ataatctttc
     1081 aacagggaaa tttcctttct ctaaagacca ataccgtaac gaactaaatc atactttttg
     1141 gttactgcca cgagtcaatg ctgcaaaggc actcgaaaaa ttattaaata ctcatcccac
     1201 ttttaaagat tataaggtga tacttgcagc tggggatgga gttagcttac gtgatagtgt
     1261 agaagaggaa gctcttgact tcaaagagaa cgcaaaaagt tttgacaaag ttagaagtgc
     1321 gattgaaaat tatgataaaa cgataacttt atccgtgggg caattgacaa caggtgtaac
     1381 tatccctgaa tggacagctg tattaatgtt aaataatatt gagtctccta gtttatactt
     1441 tcaggctgct ttcaggtcac aaaatccata tgagtttgaa aaggatggaa aattatatag
     1501 aaaagagaat gcatatatat ttgatttttc acccgatagg actttaaggc tttatgatga
     1561 ttttgctaat aatttatcgg gtagtggatc caagacaacg gatgaaagaa aaaataaaat
     1621 taaaaagtta ttaaactttt ttccagttat tgctgaagat gaagacggtg aaatgcatga
     1681 aataaacgct tctgaagttt tggcaattcc tactcgaata acatcgaaag aagtagtaaa
     1741 aagaggattt atgagcaatt tattatttgc taatatttca ggtatctttt caggggattc
     1801 accatttaaa gagattttgg ataaaatacc accagaaaaa aataaaaggt tagaaaaacg
     1861 acgagaaata cctgttacag atccacattt aaatgatgac ggggaagtag aaataccaaa
     1921 ggaagtagtg ttaggtaaat caaaggaact ttttggtgaa aagatatatg caacaataga
     1981 agttattgat gaagttgtat cttcatttga agaagcagaa gaaaagcaaa aagagtccat
     2041 taaaaattta gctaaagata taacagagtc gttttccgat ggctttacta gcttgaagga
     2101 ttcatttaat ttaaacaaag gacaaactga taaaataaaa ggtacagtaa atactgtcat
     2161 tgaagatatt ataagtgaga agagtttaac attaagtaac caagtaaaag aaatagaaaa
     2221 ggaatatgaa agcaaaaaac aagaagcaga aacaactaaa gatgagaata tgttgagatt
     2281 tgcaacccaa cagtatgaaa aagagaaaca gcaaatcgaa aagtctttta cagaagaaat
     2341 taataaagaa gtagaaaaaa cgatcaatac tgttgtggaa gaacaaatag aaaaaataga
     2401 agaaaagaaa aagaaaacaa cagaagatga tgttcgtgat catttacggg gatttgcacg
     2461 aacaatccct gcattcttaa tggcatacgg tgatgacaat acaaatttag caaattttga
     2521 agagaatatt gatgcagaca cgtttgaaga tttaacgagt ataactataa gtgaatttaa
     2581 gcagcttcgt gatggctttg agtatgttga tgataaaggt gaaaagaaag caatacccgg
     2641 tttattcaat gaggttgttt ttaatgccag tattcaagaa tttttaaata ctaaaaagcg
     2701 tttagcaaat tattttgacg atagcttaca agaggatata ttcgattaca ttcctccaca
     2761 aaaaacaaac caaattttta ctccaaaaag aatagttaag aaaatgatcg atattttaga
     2821 agaagaaaac cctgggattt tttctgacaa agcaataaaa tttgctgact tatatgtgaa
     2881 aagtggtttg tttattactg agatagtcaa gaaattaaac gatggtttga agggacaaat
     2941 tccgaatcaa caggaacgta ttaaatggat acttgaaaat caagtatatg catgtgcgcc
     3001 aagtaacatc atttataata ttgttaagaa ttttgtctat agtgatgtag tggatgtttc
     3061 gacaaaaaac ctaatagaaa tcgatacaat gattctaact agtcaagaaa aactaagtac
     3121 aaatatctat aaagcttttg gagatgataa attgaaattc gatgtaataa taggtaatcc
     3181 accttaccaa gatgaaacaa taggagataa taaaacttat gctcctccaa tttatcatag
     3241 gtttttggaa gagtcttata aactggctga taaagtagaa atgattcacc ctgctagatt
     3301 tttatttaat gcaggaagca ctccgaaatc atggaatatg aaaatgttat ctgatgaaca
     3361 tctgaaagtt gttaattatt tcgacgatag ctcaaaggtg tttccaaata ctgatattaa
     3421 aggcggaatt gctataactt atagggataa agaaaaattc tttggagaga ttgggacttt
     3481 tacagtttat gatgaattaa actcaattct gagtaaagtt gcttccaata cttcggaaac
     3541 attggattgt ctaatttctg gtcggggagt ctataaatta gcaaacgctg ctcatgagga
     3601 ttatcctgaa attgaggata tacagtcaaa gggacataag aatgatattg gttcaggagc
     3661 atttaagctg ttaaaagata ttatttttta taaagataaa cctaagcacg aaggcgaatt
     3721 tgttagaatt ttgggtcttg agaatagcca gcgtacgtat tattggatgg ataaaaagta
     3781 tctgaatgct ccaagtagtt ttgaagatta taaagtgatt atacccaaag cttatggaag
     3841 tggaacattc ggtgaagtga taagttcgcc attaatttta gaaccgaatg ttggggctac
     3901 agaaacgttt ctttcaattg gtggattttc aactaaatac gaagcagagt cagttttaaa
     3961 atatattaaa agtaaattta caagagcaat gttaggtgtt ttaaaaataa ctcaagataa
     4021 tactcgagat aagtggtcga aagtgcctct tcaggacttt actgaaagat cagatattga
     4081 ttggtcgaaa tctatttcag aaattgatca acagctatat aaaaagtata atttgagcca
     4141 gaatgaaatt cagttcattg aagataaagt gagacctatg gagtaaaagt aagcaaagca
     4201 tcgattatta ttgtattaaa ctaacatcat tattaattac ttttccaagt gtatattcac
     4261 aaaattgata aaaatggttt tcaatggttt taatatactt gaaatggata agtatgtttc
     4321 tcaaaacgct aagactgtac acttttaatg acagttttgg cgttttttat tggaacgatg
     4381 acctataatg aattgtaaga accataaaga tgattggaaa tgaatataga cggggaagga
     4441 tttaatgaac catcataaac tgtattaccg taagaattat ggaagataga ttaccaaata
     4501 atcttgtgga gtcattaagg gtagaagaag tggtaaaagg tgaacaaccg ttataagatg
     4561 ttatatatag aatgcattgg aggaatatat tatgaaaaca aaattaacag cccaagagac
     4621 tcctttacat aaagtatttt cagatgatta tttgttcact gttccatctg tacagcgtcc
     4681 ttattcgtgg acaacagatg aggcaaggga acttctggat gacttgttag aatttattaa
     4741 tcactatggt attacagaaa ataatgttag taaagttgat gaaccttatt ttctgggaag
     4801 tattgtttta gtaaaaaaag atggcccgaa atctgaggtg ttggacggac aacagcgttt
     4861 gactacactt actattttat tttctgtgct acgtgacatt cttagcgctg attatgcaga
     4921 tgatattgaa caaatggtgg tacaaaaggg tagtaagata ttaggaacaa aggatacata
     4981 tcgactacat ttacgaaaaa gggatgatga gttcctaaaa aagtacatac aagaaaaagg
     5041 aatgacacat aaggtaacga aggacacacc atataagacc gacagccaaa aggctattcg
     5101 agataatgca atgtatttta tggaacgtct aaatgagtta gatgaagata cagttaaaac
     5161 actaccatta gtattagcaa ctttatgttt cattgtagta gtttctaccc caagtttcga
     5221 ttcagctttt cgtatattta ctgttttaaa tgacagaggg ttggatttac ttccaagtga
     5281 tatttttaaa gcacgtgtaa taggagcaat ttcggaaaat gaacaagact tctacacaaa
     5341 taaatgggaa gatgtagaag tatcattagg tagggataga ttcaacaagt tgtttgatca
     5401 tatccgaatg ataatacaaa aaagaaaagg tagtgcaaat tataaagatg aatacgagga
     5461 tatcttctct aaagtaacgg gaaaagaatt cattgataat atattaattc cgtatagtga
     5521 aatttatctg aaactcttag attatcgatc ttattacagt catcaaccga agataataaa
     5581 agttttgagc ttgcttaata ggattgataa caatgattgg attcctgtgg caatgtttta
     5641 tattcaagga tatagtgaga aactagaaga atttttaaac ttacttgagc agtttgctgg
     5701 tataagcatg gtgttacgca aaaacttcaa ttggcgaatg tccaagtact ctcagatact
     5761 aaggcaaatg gaaaaaagag tcgatgtgtt ttcagaggaa tcgttattaa aggtatcaga
     5821 tgaagataag agggccgttt tggaaaaatt aaatggagat gtgtatacag agttaaaaga
     5881 tacagtaaga agatatgtat tgcttcgtct agattcatta ctaacaaacg gacaaccttt
     5941 ctatgatcac tccgttatta ctgttgagca tgtccttcca caaacaccta aagagggtag
     6001 tgattggttg gcaaactttg ctgatccttc tgagtatgtg cataaactag ggaatttggt
     6061 tctattaact cgctctaaaa attcccaagc tcgaaactat gattttaata aaaagaaaac
     6121 attatatttc caaccgaaga atggagttac gacttttgca ttaacaacac aagttgttca
     6181 agaaaaagaa tggacaccta cggttcttga agaaagacaa aagaaattga ttaacctctt
     6241 gcggcatgca tgggatctta atgtaaaata taacagtact acacctaata aagaggacaa
     6301 gaacaataat tctaatgaaa gtcacttaaa taaaaagtat tttagtaaca gattttatat
     6361 caggtatgac tgatggatat gctgtaaatc tacatcaaga gttaataggg gtaaaattgc
     6421 cataaaattt atgtgaggga tactgatgag taattttgat ataagcataa agaagcgcct
     6481 aattctatta cttgggcaaa actcggaaac ccttaaagtt gttgaaacat tgtcaacaac
     6541 aggaaatctt ttattttttg gagggtcaat aagagatttg tgtatggcac cagaagttaa
     6601 taagatgcct agagattttg acatagcaat taacttcaaa aatgaagaga aatttagtgc
     6661 gcttattggt aattataatt ataaaaagaa cagattcggt gggtataagt ttagtatatc
     6721 caatattgac tttgatgtat gggatttaaa taatacttgg gcgtttaaga ataaacattt
     6781 aaaaccaagt aaagaaaact tagccaaatc tgtttattta aatattgatg ggattgttta
     6841 taatttcaat gaaggtcttc tatatgacga tgtttttaga tcctcaatcc aaaactctaa
     6901 attagatata acgcttgagg aaaatcctga aatagaatta aacttgttaa gagcaattat
     6961 atttaaatat aaatataacc ttaacttctc agaaaaatta aaaaatgtct ttaagacatt
     7021 tatgaatatt caggaagaaa atttaattga gaatttatat caaattcaaa tagcacatta
     7081 taaagcaact tctttttcaa aagaggagat aaggaaagag ttacagtgta tttaaatgtc
     7141 attgaattaa cacggaaaac aatccacaat gttgaaaaac agtctaaagg taagttttag
     7201 actgtttttt gtaaaaaata acatcaaggt aactttcttc gcgagttagt tagatagtag
     7261 atcattaaaa ttttcaaatt atgttcttaa aaataaccat acttgttggc gttttttcaa
     7321 ggtgcagagt taaagtagat atctgaaaaa agtaaaacat atgctcagaa aatcaactcc
     7381 gaatcttaat aattcctcac ttcatatacc gatactcccg caaactctcc aaaatcgcaa
     7441 cttcctgcaa cagttcctca ccaacattcg tttccttcac tttctttcgc tcaagctctt
     7501 tgtccactaa gcgtttcacg gttaagacat cggtgccggt gcttaggact tctgccttgg
     7561 agttaaagtg tttatgggcg acgagctgca tgccgtagga gttgtatagc agcgtgtagc
     7621 cggcgatgcc tgttgtggat tggtaggctt tggagaagcc gccgtcgatg acgatcattt
     7681 ttccgtttgc tttgattggg tcttctcctt cgatttcttt tacgggtgta tggccgttaa
     7741 tgatatggcc atgatctgga ttgaggccga attctgccag gatgtttcgg caggttgcct
     7801 cgtcttcgcg taaataataa tacgggtttt tcttttcttt atgcgtttcc ttctctttga
     7861 tgaaatagcg ctcaaatgtc gtcatggcgc gttttccgaa gagggaggag tattcgcctg
     7921 tccataaata ccaagccata tctgtcgcca ggtcatcggt ttcttccggg tgggcaaagg
     7981 cttcccgcaa gaatcgttca aatacatcga gcagctcacg gcccgcatac ggtttatcct
     8041 caatcatcat cgtttccata ttgccgtttt catcaactgg aatacaaccg tgaatcaaca
     8101 ggttgccgtt atattttaaa taaaggctgc cttttttcat cataaaattc atatggcggc
     8161 ccagcttttc ggaatgctgg acagagaata gcagcttgtc tatgacttct gcttcttctt
     8221 ctaatagctg atctggctgc tccggattaa tcgtcgcaaa gcaggtgttt tccagttgat
     8281 atgtttttcc gtttagcgtg atttcgtttt tgtcataatc tattttctct aataacagcc
     8341 gctcttccat attaaagttc ggccgtctct tgataatcgg gctctcaagc ttgaattgaa
     8401 tcatcgcaat cgcttgatgg atttttgtga tttgcttaat ctcgtcctct ggcctgttgt
     8461 cgtctgcttt tggacggaac gctgggttat catcataata tttttcggcc aggttcagca
     8521 gcggtctcag gttgatgccg tacacgtcct caataatatc caggttgtcg tagcgggcac
     8581 agatgcggat aatattggcc aggcacactt tggaaccgga ataggcgccg atccaaagga
     8641 catcgtgatt tccccactga atatcgacag aatgatagtt gatcagttct tccataattc
     8701 tatccggctg cgggccgcgg tcataaatat cgccgaccac atgcagatgg tcgaccacca
     8761 atcgctgaac gctgtaagca aggccggtga taagcttatc ggcttggcca agctcaatga
     8821 tctgatcaat gatttcggag taatattgct ccttgttgcc agcttgttct gttttgtata
     8881 acagctcctc cgtaatataa gcaaattggg caggcagtgc tttgcgtaat ttggagcggg
     8941 tatacttgga ggagcaatat gaaacgagct taatcattcg atgaatcgtt tctttatacc
     9001 actcgtttaa tgctgctttc gcatcaaagt catgtttgat taacttcagt ttgtcttccg
     9061 gataatagac caatgctgct aattcatcaa tttctctatc gtaaatgaca ccgctgaaga
     9121 tgtcgcgtat cttctctttg actcgtcctg aaccattacg cagtacgtgc tgaaatgcct
     9181 gatactcccc gtgcagatca ctgacaaaat gctcggtgcc ttttggcagg ttcagtatcg
     9241 ctttcaaatt gatgatttct gttaccactt tttcttcaca atcgtatttt tgtgcgagta
     9301 gatctaggta cttgctttcc aaaaccgtcc atcccctttt tagaataaac ccctatttat
     9361 gagcatgtgc atgataaggt gaatttaaaa gtatgacatt atttttaaac attggacctt
     9421 tatatgatag taccgcataa ctgcttttat agacaattga aacgagtgaa agaggtgcca
     9481 aatgggggaa gcaagagctt aaaacagctt ttcagtacag gttggtttag ggtaagattg
     9541 tttgcctcat ttcttccact taaaatcttt atatccctta actagtgtag tcaatattga
     9601 tgttttactt ttcattacga agctttaaat caaactatgg cctttcattc ggtatagctt
     9661 agaggggcta gaggactata ggctttatat accaagaata gtgacatttt tcagattttt
     9721 taggtacaat atattgacat gtattgaatc atatagaata attggtttat attagaaaag
     9781 aaggagggat aatatgaaaa aggaaaacac taacaatgag actgtgaaaa acttagaatt
     9841 taagggtcta ttagatgaat cacaaaagct agcaaaagtg aatgatcttt ggtattttgt
     9901 aaaatcaaaa gaaaatcgct ggattcttgg aagtggtcat taattagagg ggtacaaagg
     9961 agagtctaac tctcctttac catttgttgg gggatatttc atgtataata aaacagtatc
    10021 aatcaattta gattcaaggt gtaatgcatc ctgtgaccat tgttgttttt ctagttcacc
    10081 aacttcaaca accaggatgg aaaaagaata cataagagag ttagtaactg aatttgcaaa
    10141 aaacaaaacc attcaagtga tttcttttac aggtggggaa gtttttttag attataaatt
    10201 tttaaaagaa ctaatggaaa tcattaaacc atatgaaaaa caaataacgt tgatctctaa
    10261 tggattttgg ggtttgagca agaaaaaggt ccaggagtac tttcatgata tgaattcttt
    10321 aaatgtgata gcactgacta taagttatga tgagtaccat gctccatttg tcaagtcttc
    10381 cagtattaaa aacatattag aacatagcag gaaataccct gatatcgata tttctcttaa
    10441 tatggcagtt accaaagaca aaatgtccaa ccatatttta gaggaattgg gggattcaat
    10501 cttaggtgta aagataacaa aatttccaat gatatcagtt ggcgctgcta aaactagaat
    10561 taagcaagaa aacatacata aattttacag tcttgaagat gaagattcct tacattgtcc
    10621 cggatatgac attgtatatc atcatgatgg agaaatttat ccatgttgtt cccctgctat
    10681 ttttgaaacg aaaataaccc taagggaaga atataaccaa agtttcgaaa gaaccgtgga
    10741 aaagttaaat tccaatttgc tattatttat tcttagaaaa gaaggattca aatggttttt
    10801 gaatatttta aaagagaata acaagataga ggaatttgac attccttatg aattttcctc
    10861 tatttgtgga gtttgtggtt ccttattcaa ctctgcagaa aaaataaact acttctatcc
    10921 ttatatggaa aaatactata atgaaaattt taaagtatga agatgaaaaa tatgaagtgc
    10981 ttgtgcaaaa caacgtattt ataaaagaca aaaaaagcgg agaatactat aaaaatagtt
    11041 taaattctct gtcagatgaa caattattac gttttaaaat gtataaagag aaagtatcac
    11101 caaagttttt ttatctgttc ttatccttta cggctctcat gttcatatta aattatattc
    11161 atttaataaa attgcaaaat ggattgtcct cagtatttta cggctggaaa atgtggataa
    11221 ttatagttat ttactttata atgaatatag tgcttcatga actgggacat atttattcct
    11281 taaaattttt cgggaaaaac tttgataaag tgggattcaa actgaatttt tatgtatttc
    11341 ctgcttttta tgtccaattg aatgaaacct atatgctatc aagaaatgaa aagataatcg
    11401 ttcatttatt tggcttgttt atcaattatt ttttaataaa cacattagaa ttaataaatc
    11461 aatttacatt ttccagtgaa gcattaacta tggcatttat gcttttctcg tctactttat
    11521 tgtggaactt aattccaata ctgaattctg atggttacaa aattctttta gcttttctga
    11581 gcttagatga atatagccgt tttaagacaa atcattggtt agttcttacg attcaaatta
    11641 tagggattgg ccttgcagtg aattcagttg tacattggat attatatatt gtaaactaga
    11701 gtaaaagatc tccaaattag ccatctaaaa acatttcttg cgcttccaga tcggaaacga
    11761 aagaggtacc tcaaaagctt agacattagt aacaaatcac aaggcagaac attttattat
    11821 tatgcaaata tttcctagga gtatgtatat gaatatagcg aattacactt taaaagtgaa
    11881 aggcaaaacg ttacttcagg acaccgactt gcatttttcg agcgggaaaa ttaatcacgt
    11941 tgtcggaaaa aatggagtcg gtaaatcaca gcttgctaaa gactttttgt tgaataatag
    12001 caagagaatc ggcagagata ttcgtcaaaa tgtttcttta atatccagct cgtcgaatat
    12061 acctaatgat gtttctaagg actttttatt acactttttg agtaaaaaat ttgatgcaga
    12121 aatgatagat aaaatcgcac atttacttaa tctggataat attgatggaa aagttctgat
    12181 caaaaatttg agtgatggac aaaagcaaaa attaaaattg ctcagtttct tattagagga
    12241 taaaaatatt attgttttag atgaaataac gaattcatta gacaaaaaaa cggttataga
    12301 gattcatggc ttcttaaaca agtatattca ggagaacccc gagaagatta tcatcaacat
    12361 tacacatgat ttgtctgatt taaaggcgat agaaggggat tattatatat ttaatcacca
    12421 agaaattcaa caatatcatt cagtggataa attaattgaa gtgtatataa atgagtaata
    12481 aaacagtggg ggcttgagat gaaattagag tttaaaaaga gtattagcaa caaagttatc
    12541 attattttag gagcaatgtt tgtattttta tttttgctgg gttatttttt acttgttgga
    12601 attgataaag tcagcaatgt tacacctgaa atgtttttct ttagctccta tactgttgcg
    12661 acccagtttg gtttgatgtt attttcattt gttatagctt tctttattaa tagagagtat
    12721 tcaaacaaaa atattctctt ttacaagtta attggagaga acatctatac tttcttttat
    12781 aaaaagatag ctgttttatt tttagaatgt tttgcattta taacgctagg cctgctaatc
    12841 atatcgttga tgtaccatga tttttcgcat tttgcattat tacttttttt attttctgca
    12901 gttatactgc agtatattct aattatcgga acgataagca tgttatgtcc taatatatta
    12961 attagtatag gtgtcagtat cgtttattgg atgacttctg ttatcttagt agctataagc
    13021 aataaaacgt ttggtttcat tgctcctttt gaggcaggta acactatgta tccccgaata
    13081 gaaagggtgc tgcaatctga taacatgaca cttgggagta atgatgtttt atttattatt
    13141 ttgtatttag tttcaattat tatcataaat gcgattatcc ttcgcttttc taaaactaga
    13201 tggatcaaaa tgggcattta ataaaggaag ctacttcaca atgaagtagc tttttatgtg
    13261 cacctatata tcattaacat caagattaat gcatgtgact ggctgagttt gttaagggaa
    13321 ggatgttttt ctgtttgcat cgcccaaact attattgttt ttctttcacc agctttacaa
    13381 agaggaaaaa gatagtgaat acgataaagt agttcattgg attcttaacg atgctcatct
    13441 ctagtgaaat ctgtaagagt atccagagcg caaagatggc tagtatggca ggaatgataa
    13501 ttttgtacat gtcgaccacc taccgtagtg aagagcccta taataaaaaa ctattagcct
    13561 gtaccacaaa ctgcgactgc tcataattat acgaaatctt cgagtaatca aacggctgcc
    13621 catttgtcag gtgaaaaata ctttctatat acagcttcgg cagtccagcc tctaatccca
    13681 aatattccgc ttcttcctca ttaagctggc ccacgtgcag aaacaaatca gaaaaaccaa
    13741 tcttcaaccc cagtccttcc cggatgtaat ggaaggtgga gtgggagacg atttcgttgt
    13801 ttaaatacgt cacgatggat ttggtgtaat aggattcttc gtagcaaagg gtctggccgt
    13861 tgatgtagcg gacccttttg acatagtaga tgtcctcgtc cattccgatg ttcaggtttt
    13921 ccgccgcttc cggtgttggc tttctcacgt ccagttcgat gacttttgag gtgacgttga
    13981 aatcctcgag atctttttta aatccctgat tcgacagaag gctgatatag ccttttcgtt
    14041 tatgttttct gacgaaaatg ccgcttcctc tgacctgaaa gatcgcgcct ttttgctcta
    14101 atagctcgag ggactttgtg attgtgcttt tgctgacttc aaactgggcc atgagggttt
    14161 ctaggactgg cagtttgtct ccctgctgaa gctggtgttc ttctatatat gtttcaattt
    14221 ccgttgcgat ttgctggtat tttaacatac gcattcctca tttattcgtt tagtttcact
    14281 tgtcaaaatt atagcataaa ccgcttacaa tgatagttag tgcgttaata ttttgtttcg
    14341 gcattgataa attataccgg tacaattata atgaaagcgt aaccaaaaca aaggggtggg
    14401 tgaaaatgtc ggggaaagtg agagattata cgagactagc aaaagacatt ttagaggccg
    14461 taggcgggga agagaatgtg attggggctt ctcgctgcgc taccagactt cgattggtgc
    14521 tgaagcggtc tacccctaaa gcgaaggata tcgtgaaatc gatgctacca tcccggcgtc
    14581 attacggttg tcatggttac gcctacaaag catgcgattg gcctgcgttc agcgtccggc
    14641 gtcgaattgc ttgcgcacat cgggctggat acggtgacat taggcggcac tcctttttcc
    14701 ttgaaggtaa aagaaggcga taccgtcaaa aaaggcgaag tgcttgttga gttcgataaa
    14761 gctttcattg aagagattga ggaaagtgca ttacatcaaa aaatatttac agtcgtaagc
    14821 tgaggaggaa ttaaacatgg gaaacatgcc aaaggatttt ttatggggcg gtgctttagc
    14881 tgcccaccaa tttgaaggcg gatggaatca aggcggtaaa gggccgagtg tcgtcgatgt
    14941 gatgacagcg ggtgcgcacg gcgtgccgag aaaaatcacg gacacgattg aagaaaacga
    15001 attttatcca aaccatgaag ccattgattt ctatcacaga tacaaggaag atatcgcttt
    15061 gtttgcggaa atgggattaa aatgcctgcg gacgtccatc ggctggagcc gcatttttcc
    15121 gaaaggcgat gaggctgaac cgaacgaagc gggtttgcag ttttatgatg atgtgtttga
    15181 tgaattgctg aagcatggga tcgagccggt cattaccctg tctcactttg aaatgccgct
    15241 gcacctggca agagaatatg gcggcttcag aaaccggaaa gtcgtggact tcttcgtcaa
    15301 ctttgcagag gcttgcttta cccgttacaa agagaaagtg aagtactgga tgacatttaa
    15361 cgagatcaac aaccaaatgg atgtgaacaa tccgttgttc ctatggacga attcaggtgt
    15421 tgtggttggc gaaaacgaaa acgccaagga agtcatgtat caaacggcgc accacgaatt
    15481 agtggcgagc gcattagcag tggcaaaagg aaaagacatc aatccagagt tccagatcgg
    15541 ggctatggta tcacacgtgc cgatttatcc tttctcctcc aatcctgaag atgtgatgct
    15601 ggctgaagaa gaaatgaggc agcgctattt cttccctgat gtgcaagttc gcggttatta
    15661 tccaagctac gcgttgaagg aatttgaacg cgaaggctac aacatcacat tcgaagacgg
    15721 cgatgatgag attttaagaa acggaaccgt cgattactta ggcttcagct attacatgtc
    15781 aacaactgtg aaaagcgatg tgaaaaatga taacactggc gatattgtaa atggcggctt
    15841 gccgaatggt gtcgaaaatc cgtacatcac ttcgagtgac tggggatggg cgattgatcc
    15901 aaccgggctg agatatacgt taaatcgttt ttatgaccga taccaaatcc cgttattcat
    15961 cgttgaaaat ggctttggcg cagtggatac gctggaggag gacggcaagg ttcatgatcc
    16021 ggaacgcatt caatatttaa aatcgcatat tgaagcattg gaaaaagcgg tcacgtacga
    16081 tggtgttgat ttaattggct acacgccgtg gggcattatt gatattgtct ccttcacaac
    16141 tggcgaaatg aaaaaacgct acggcatgat ctatgttgat cgtgacaatg aaggaaacgg
    16201 atccatgaaa cgatataaaa aagactcctt tgaatggtac aaaaatgtca ttcaaacgaa
    16261 cggagaggaa ctataagaag ctggcccgaa tcgagcactg gttcgggttt tttctgtaga
    16321 aaaagaaaaa tccgctatcc tgccaatctg gcaaaatagc ggattttttt atcagttacg
    16381 gattaggtaa tcaaacgcgc cgagagcggc agttgcacct gatcccatag aaataataat
    16441 ttggttgtac gcactgtctg tgcagtcgcc ggcagcaaat aagcctggta cgcttgttgc
    16501 gccatgtttg tcgacgatga tttcgcccat gcggttgcgt tcaaccgttc cttctaacca
    16561 ttctgtgttt ggcacgagac cgatttggac gaatacacct tgaagttcaa cgtgtttttc
    16621 ttcgcctgtt tcgcggtcta catatgtgat gccgttaaca ctctgatcac ctgtgatttc
    16681 ttttgtttgt gcgtttttca cgacagtgac gttaggcagg ctgtagagac gtttttgcag
    16741 gacttcgtct gctttcagtt ccggcgcaaa ttctagcacg gtaacgtgat tgacaatacc
    16801 tgcaaggtca attgctgctt cgataccaga gtttcctccg ccgataaccg ctacgtcttt
    16861 gccttcaaac aatggcccat cacagtgcgg gcagtatgcg acacctttgt ttttgaactc
    16921 ttgttcacca ggtacgttga cattgcgcca gcgtgcacct gttgaaagga tcactgtttt
    16981 acttttcaga acagcgccgt tttcgagttc aagttcgaac agatctttct tctcaaggcg
    17041 tttcgcacgc tgaaggttca taacatcaat atcatattcc ttcacatgct cttcaagact
    17101 tgccgcaagc ttcggccctt ccgtcgcttt gacgctgatg aagttttcga tgctcatggt
    17161 gtcgagaacc tgtccgccga agcgttcagc gacaacccca gtgcggatgc ctttacgtgc
    17221 agtgtagatc gccgcacttg caccagcagg tccgcctccg acaacaagaa cgtcaaacgg
    17281 ctctttgtca gcaaactcag atgcatctgc gccgctgccc attttcgcaa ggatttcttc
    17341 aagcgtcata cggccgcttc cgaaggattc gccattcagg taaacggtcg gcactgccat
    17401 gatgtttttg ctttcaactt ctgctttgta tgctgcaccg tcaatcatcg tgtgcgtaat
    17461 gttcggattc agcacgctca tcatgtttaa agcttgtaca acatcaggac agttgtggca
    17521 tgtcaggctg atataagatt cgaagtggta ttcaccgctg atcttcttca cctgatcaat
    17581 gactttttgg tccaccttag gcggtctgcc gctcacttgg agcaacgcca acactaatga
    17641 tgtgaattcg tggcccagag ggataccagc gaaagttacg ccagtgtctt ctccgacacg
    17701 attgacactg aagcttggcg ttctgtttaa ttcagctttt tcaactgaaa ttttcgatga
    17761 catggaagcc agctcatcaa cgagagccag catgtccttt gaaatgtcat cttcgcctgc
    17821 gctaactttg agaacaatgt cattctcaat tagctgcata tattgattta attgtgcttt
    17881 gatatttgca tcaagtacca attgaatgca ctccttagat tttacctact agatcaaggc
    17941 taggtgtaag agtttcgccg ccttcttccc atttagccgg gcaaacttca cctgggtttt
    18001 gacgaacgta ttgagctgct tttactttgt ttacaaggtt gcttgcgtca cggccgatac
    18061 cgcctgcatt gatttcaaca gtttggataa cgccgtctgg atcgatgatg aatgttccgc
    18121 ggtcagcaag accagtttct tcgtcaagaa catcgaagtt gcgagaaatt gtttgagatg
    18181 ggtcaccgat cattgcgtaa gtgattttgc cgattttttc agagctgtca tgccagcctt
    18241 tgtgtacgaa gtgagtatct gtagaaacag agtatacttc aacacctaat tctttaagag
    18301 cagcatattg ttcttgaaga tcttcaagct cagttgggca tacgaaagag aaatctgctg
    18361 ggtagaagca gaatacgctc cattggcctt tcaaatcttc gtttgttaca tcgatgaatt
    18421 caccgttttt gaatgctttt gcttcgaatg gaagtacttc tttaccgatt aaagacataa
    18481 tgtatattcc tcctaaaaat gtattagaaa gcatattcgc tttcaataat aattctaatt
    18541 atatatgaat tattaattaa tatatatttt ttgtcaagcg ataacctact ttttttcaac
    18601 ttatttaagg tatgacaggt aggatttagg tatttctttt ataacaaatg agaggctgat
    18661 tctcaattag acaaggtttt cagggacttt tgtaaatcag aatgacaggc cgttttggca
    18721 tttgaacatt ttatgacacc atgggcaagg gcaaaggaca atggccaaga gcagaataga
    18781 acggaacagc aagctgctgt cacatgatga tggggattgt ttctagctat tattgtatca
    18841 ctgtttatga tatttaaaac ataacttatg tcttctgttg tttgagatag aagaaatcat
    18901 agatgaaaaa aacacggttc agttgaaact gaccgtgttt ttgatgacag gttattcaga
    18961 ccaattcgta tggaaaacgc cgtccatatc agtccgttcg tacgtgtgag cgccaaagta
    19021 atcgcgctgc gcctgcaaga ggttcgcatt ggaacgccct gtgcggtagc cgtcgtaata
    19081 agagagcgcg gtagttaagc atgggaaagc gattccggtg ctgataccct cgcaaacgat
    19141 ttttcgcagg cctgtttgat aggcatggag cttatctgtg aaataaggcg cgatcagcag
    19201 gttagccaga tttggctgct cactgaatgc ttcgctgatc acgtttagga aatcagcgcg
    19261 gatgatgcag ccgcctcgga aaatcaaggc aatgtctttg agcggcagat tccagccgta
    19321 aagctcagat gacatcttat attgggcaaa gccttgtgca taggcgcata ctttccccat
    19381 gtaaagagcc tgtctgacgt attcaatcca ggtgtcttta tccaagtgtt tttcttcgga
    19441 ttccgggcct gctaatacgt cttgagctgc catccgttct tcttttaagg atgacaagta
    19501 gcgggcgaac aaggactctg tgatgatcgt ggacgggatg ccgttatcaa tcgcctgcat
    19561 gctcgtccat tttccagtgc ctttttggcc ggttttatca aggatgacat cgatcagagg
    19621 ctgtcctgtt ttttcgtctt ttttgcgtaa aatctcagct gtaatctcta ttaaatagct
    19681 tttcagctca ccttgattcc atgtttcaaa aatagatgca atttcatcta gcggcagacg
    19741 aagcgtttct cttagaaacg tatacgcttc tgcaatcagc tgcatgtcgg catattcaat
    19801 gccgttgtgc accatttttg taaagtgccc tgcccctttt ggtccgatat agacacagca
    19861 agggtcatct ccgacttggg ctgcgatttt cgtcaggata ggagcggctt tctcatagac
    19921 gtcgcgatct ccgcccggca tgatggaagg ccctgttaac gcaccgactt caccgccgga
    19981 aatgccgact cccaggtagc cgatcccttt ttccttcagc tcgtcatatc ttctttctgt
    20041 gtcttcataa tgggagtttc ctccatccat gatgacgtcg ccttcttcaa gcaaaggctt
    20101 taatgattgg atgacggaat ctacgggttt tcccgctgtg accatcaaaa agatttttct
    20161 tggtttttct aacgattgaa caaagtcctc aagctcgtaa tacgggctga gagattgtcc
    20221 atccagcttt tggacaagct ggtccgttaa atctctggtg taattataga cagcgacgtt
    20281 ttcaccttta tttgccatgt ttaaggcgat gttgcttccc attacgccta agcctatgac
    20341 accaatcgta ttgaacatgt gttacagctc cttcttaatt tcatacaact aaacttaaca
    20401 ataaaatgaa tcccagtcca gcaacggaaa taatggtttc cagcaatgtc catgtggcga
    20461 atgtttcttt catgcttaat ccgaagtatt ccttgaacat ccagaagccg gcatcattga
    20521 cgtgtgaagc gatgacactt ccggcgcctg ttgcgagcac gactaacgcc aggttaacat
    20581 cagaatggcc caataacggg atgaccagac ctgttgtgct tagtgcggca acagtcgctg
    20641 atcctagaga aatgcgcagg atcgccgcga tgagccatgc cagaatgatt ggcgataatg
    20701 ccgttccttt gaataagtct gctacgtaat cgccgacacc gccgttgatc agcacttgtt
    20761 tgaaggcgcc gcctcctccg atgatcaaaa gcatcatgcc gatttgtgaa atggcagttg
    20821 aacaagaatc catcacggtt ttgactggaa tgttgcgctt gatgcccatt gtatagactg
    20881 cgaccaataa cgaaataatc atagcagtcg atgcgtttcc aatcaatctg ataaaagcta
    20941 aaactccgtt atctgcaaac ccgattgttt cttgaagcag gtcgataatg gtcgcgaccg
    21001 acatgatgat aatcgggagc attgcggtaa agacactgat tccaaagccg ggtgtttctt
    21061 caaggttaaa cgttttttgt gtgccgagtg atgcaatatt gccgtttttc gcaaatgatg
    21121 caggaacgat ttttttcgcg aactttgtaa ataacggccc tgcgatgagc actgtcggaa
    21181 cagcaacaat aaagccgtac agcagcactt ctccaatgtt tgcgccatac tcaccggcga
    21241 tcgccgtagg tcccgggtgc ggcggcagga aaccgtgtgt gacggatagt gccgcgacca
    21301 tcgggattcc gagaaataaa atagaaatct tcaattctct tgaaatcgca aagacaatcg
    21361 gaattaatag aaccagtcct acttcaaaaa ataacgcaat cccaataatg aatgaggcaa
    21421 tgacaacggc ccattgaata tttttctcgc caaatttgtt gacgagcgtc atcgcaatgc
    21481 gctgtgcgcc tcctgaatcc gcgatcagct tgcccagcat cgcaccgagt ccgaagatga
    21541 gcgcgatgtg gccaagagtc ccccctattc ctgcttcgat ggagctaaca actttatcga
    21601 acggcatccc gagtgccagt gccacgccga acgatacgac cagcagggaa ataaatgtgt
    21661 ttaattttaa gcccataatc agaaatagta atgctaaga
//
