LOCUS       NZ_JAPWIK010000007     25366 bp    DNA     linear   CON 14-FEB-2024
DEFINITION  Rhodococcus qingshengii strain IEGM 766
            NODE_7_length_276774_cov_282.431474, whole genome shotgun sequence.
ACCESSION   NZ_JAPWIK010000007
VERSION     NZ_JAPWIK010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Rhodococcus qingshengii
  ORGANISM  Rhodococcus qingshengii
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Rhodococcus; Rhodococcus erythropolis group.
REFERENCE   1  (bases 1 to 276774)
  AUTHORS   Krivoruchko,A.V. and Elkin,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-DEC-2022) Lam, Institute of Ecology and Genetics of
            Microorganisms, Ural Branch of the Russian Academy of Sciences,
            Golev Str., 13, Perm, Perm Kray 614081, Russia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2022
            Assembly Method                   :: SPAdes v. 3.15.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 311x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/14/2024 02:58:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,449
            CDSs (total)                      :: 6,385
            Genes (coding)                    :: 6,320
            CDSs (with protein)               :: 6,320
            Genes (RNA)                       :: 64
            rRNAs                             :: 1, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 5 (23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 17 of 65
            Pseudo Genes (incomplete)         :: 52 of 65
            Pseudo Genes (internal stop)      :: 6 of 65
            Pseudo Genes (multiple problems)  :: 9 of 65
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:17:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 158152
            Orig. end                         :: 183518
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPWIK010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25366
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25366
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25366
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15366](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15366
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    451..465
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.69"
                     /tool="antismash"
     gene            complement(1459..2103)
                     /locus_tag="O4271_RS22870"
                     /old_locus_tag="O4271_22865"
     CDS             complement(1459..2103)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748878.1"
                     /locus_tag="O4271_RS22870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22865"
                     /product="hypothetical protein"
                     /protein_id="WP_003941715.1"
                     /transl_table=11
                     /translation="MSRQGKSGAAQRAYDKRTARAAGRTGTVAAAGPSISPRAMLKGRV
                     PFVASVIGLLSIGLAVTLLLTTRAAEDSYQLSDARAYNQSLVEQKAALERDFQSRNSAP
                     ELANQASALGMVPAKDPARLVVHPDGSVEVVGTPTPATAGAMPPLDAPTSVPAPTATPP
                     RTTTPVAPGATPSVPNNTRNLAQSEQLVPVIPTTTAPATTTAVPAPPEERR"
     gene            complement(2100..3113)
                     /gene="rsmH"
                     /locus_tag="O4271_RS22875"
                     /old_locus_tag="O4271_22870"
     CDS             complement(2100..3113)
                     /EC_number="2.1.1.199"
                     /GO_function="GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730079.1"
                     /locus_tag="O4271_RS22875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22870"
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="WP_269613647.1"
                     /transl_table=11
                     /translation="MVDHEVNEPSDADGFAHVPVLLHRADDLLGPAITAVGDGGAGAYM
                     IDATLGLGGHSEFFLGKYPGLHLIGLDRDTNALRIASERLAPFADRTTFVHTTYDGIED
                     ALEQAGLPSTESVHAILFDLGVSSMQLDEADRGFAYSIDAPLDMRMDQTVGLTAAEVLN
                     TYSHGDLARILSTYGEERFAGKIASEILRQREREPFTTSAALVELLYRTIPAATRRTGG
                     HPAKRTFQALRIEVNAELDSLRAAVPAGLDALAVGGRVVFMSYQSLEDRVVKAELVPRS
                     KSTSPEGLPVELPGMGPEFRILTRGAERASEQEIEENPRSAPVRLRAAERISRRRT"
     gene            complement(3304..3735)
                     /gene="mraZ"
                     /locus_tag="O4271_RS22880"
                     /old_locus_tag="O4271_22875"
     CDS             complement(3304..3735)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0051302 - regulation of cell division
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mraZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011560648.1"
                     /locus_tag="O4271_RS22880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22875"
                     /product="division/cell wall cluster transcriptional
                     repressor MraZ"
                     /protein_id="WP_003941779.1"
                     /transl_table=11
                     /translation="MFLGTFTPKLDDKGRLTLPAKFRDELAGGLMITKSQDHSLAIYPR
                     DEFVKLARKAAAAPRNDPAARAYVRALAAGTDEQHADAQGRITLSADHRRYANLSKECV
                     VTGSVDYLEIWDLAAWERYLGDNEEDYSQATGESLSEIV"
     misc_feature    complement(3863..3877)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.88"
                     /tool="antismash"
     gene            complement(4330..4776)
                     /locus_tag="O4271_RS22885"
                     /old_locus_tag="O4271_22880"
     CDS             complement(4330..4776)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005247640.1"
                     /locus_tag="O4271_RS22885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22880"
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_003941660.1"
                     /transl_table=11
                     /translation="MPLSEHEQRMLDQIESALYAEDPKFASNVRGGRMRAPSSRRRFQA
                     AALFVLGLVLLIAGVALPLKPGGFPIISLFGFLFMFGAGVLFLWGGGRKSAPAADSASE
                     GGNHPSGPPGRGSAGGSGRGRGRKSGGGFSSRMEDRFKRRFEQD"
     gene            complement(5014..5565)
                     /locus_tag="O4271_RS22890"
                     /old_locus_tag="O4271_22885"
     CDS             complement(5014..5565)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748881.1"
                     /locus_tag="O4271_RS22890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22885"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_231783463.1"
                     /transl_table=11
                     /translation="MSERVKPERVKCQRTLPAELSSPSDAAISRLPMSARRSFGATDAS
                     HRTARVGKSGVAWGLLRKADALLEEAIGAGDPADRFRCAYLAALRGAGAVLAAAPAGAG
                     SKRKRSGNAWVLMDAAAPAFGAWSKFFAGWSATRAAVETGVSIVITDSDSDAFFAEVGR
                     FLTAVEDFIGQDASEHLRAS"
     misc_feature    5651..5666
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.27"
                     /tool="antismash"
     misc_feature    complement(5652..5665)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.07"
                     /tool="antismash"
     gene            5713..6318
                     /locus_tag="O4271_RS22895"
                     /old_locus_tag="O4271_22890"
     CDS             5713..6318
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748882.1"
                     /locus_tag="O4271_RS22895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22890"
                     /product="N-acetyltransferase"
                     /protein_id="WP_003941672.1"
                     /transl_table=11
                     /translation="MRPVDPQIAWTPHTVDLDRAEFASRLHEALAVYVTAMDYPRGTEF
                     HRAPMWQEHANRPGWKAVGALAVPQQPSHENLPLVGIAYGYRGSPDQWWHQQVLHGLRR
                     SGRPQSEIDAILSDYFELTELHVHPNGQGHRLGESLLRHLLVDRPERSVLLSTPEVYDE
                     DNRAWRLYRRLGFRDVLRRFRFAGDNRPFAVLGRGLPL"
     gene            6315..7913
                     /locus_tag="O4271_RS22900"
                     /old_locus_tag="O4271_22895"
     CDS             6315..7913
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748883.1"
                     /locus_tag="O4271_RS22900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22895"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_269613528.1"
                     /transl_table=11
                     /translation="MSALLDAVVVGSGHNALVSAAYLAREGWSVEVLEKDTVLGGAVST
                     VERFPGYMVDRGSSAHLMIRHSGIIEELGLGAHGLRYIDCDPWAFAPPAPGTDGPGIVF
                     HRDLDATCWSIERACGTKDADSYRRFVAVWSERSRHVMKAFSAPPTGSNLIGAFGGLAT
                     ARGNSELSRQFLAPGDALLDEYFDSEALKAALAWFGAQSGPAMSEPGTAPMVGFAALMH
                     VLPPGRAVGGSGALSAALASRMAVDGATVALGDGVTSIRRNSSHWTATTESGREVHARK
                     VIAGCHILTTLDLLGRGGFDRTTLDHWRRKIRVGPGIGAVLRLATSALPSYRGDATTRE
                     STSGLQLLVSDRAHLRTAHGAALAGELPPRPAVLGMSFSGIDPTIAPAGRHQVTLWSQW
                     QPYRLSGHRDWASVAEAEADRIVGEMEAFAPGFADSVLDRFIQTPRDIESELGMIGGNV
                     MHVEMSLDQMMLWRPLPELSGHRVPGADGLYLTGASTHPGGGVSGASGRSAARIALSDS
                     RRGATRRWMRRSSRS"
     gene            7984..8778
                     /locus_tag="O4271_RS22905"
                     /old_locus_tag="O4271_22900"
     CDS             7984..8778
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003941798.1"
                     /locus_tag="O4271_RS22905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22900"
                     /product="DUF3153 domain-containing protein"
                     /protein_id="WP_269613530.1"
                     /transl_table=11
                     /translation="MTTVQQSTDPAAKPTSRKRFLTVAALALMLVPLLAGCIRVQVSMG
                     VSANDRVTGQVVAAAIPANEADKGPQLTPPSSLEDKIRVQEYKKDGYVGSQAFFSDLSF
                     GDVTQLGSMYAEGSGSFQITLKRSGDTVTLDGKADLKTVPTQGADVQVSIAFPARVGTT
                     NGTRDGDSRVSWTLPAGEVSTMRAEVNYADPSTRSFAGWAGIMAGLALGVAIVVGAMAW
                     MARNRAPIKRAPAAKAPVMKTPVTKSPASKQADNRNPKNTTK"
     misc_feature    complement(8033..8044)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.3"
                     /tool="antismash"
     gene            complement(8841..9830)
                     /locus_tag="O4271_RS22910"
                     /old_locus_tag="O4271_22905"
     CDS             complement(8841..9830)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0006555 - methionine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003941803.1"
                     /locus_tag="O4271_RS22910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22905"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_003941803.1"
                     /transl_table=11
                     /translation="MTFDPVRGRSSEGWATRTPSIVDRIASSTGSRIPFSVEFSPPRDA
                     DAEARLWRAVRTFERLGPAFVSMTYGAGGSTRDRTVRVTGELAEETTLLPVAHLTAVSH
                     STEELRAMVGAYADRGISNILVLRGDPPGDPLGEWKKHPEGVEYAEELVRMVRDLGDFH
                     VGVASFPEGHYRAPDLAYDTKYLVSKLRAGAEYSITQMFFDVEDYLRLRDRVSAYDAEQ
                     GAKPIIPEIMPVTSLRSVRRMLELSGSSLPPALERRFDAAAGSGPDENRAAVRELGIDL
                     ATEMGERLIAEGAPCLHFITLNFARATSEVLERLGLTPDTSVGTAQAV"
     gene            10001..11140
                     /locus_tag="O4271_RS22915"
                     /old_locus_tag="O4271_22910"
     CDS             10001..11140
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748885.1"
                     /locus_tag="O4271_RS22915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22910"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_269613532.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.3e-50, bitscore:
                     164.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEATLSAGTARVGQSSTNTAPHPTSLELPGLFEAALRDFFASRRE
                     LVSNIGGGYEEAVSTLEAFVLRGGKRVRPSFAWTGWLGAGGDPNGKDADAVIRACAALE
                     LVQACALVHDDIIDASTTRRGFPTVHVEFEDQHRDEEWSGDSAHFGEAVAILLGDLALA
                     WADDMIRESGISPEAAARVSPVWSAMRTEVLGGQFLDISNEARGDETVEAAMRVNRYKT
                     AAYTIERPLHLGAALFGADAELVDAYRTFGTDIGIAFQLRDDLLGVFGDPSVTGKPSGD
                     DLIAGKRTVLFAMALARADAADPAAAELLRNGIGTQLTDTEVDTLRQVITDLGAVNDVE
                     TQIDTLVEAAANALDSSTATAESKARLTDMAIAATKRSY"
     gene            11143..12735
                     /gene="crtI"
                     /locus_tag="O4271_RS22920"
                     /old_locus_tag="O4271_22915"
     CDS             11143..12735
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003941668.1"
                     /locus_tag="O4271_RS22920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22915"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_269613534.1"
                     /sec_met_domain="DAO (E-value: 1.2e-12, bitscore: 42.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHVHRTRTVSSPTDRVVIVGAGLAGLSAGLYLRGAGRDVTILES
                     NSSVGGRVGVYQGNDYSIDNGATVLTMPELVEDALAAVGADPASTNPKFVVHKLDPTYH
                     ARFADGTALDVHADPEDMAAEVSRVCGPEEAQRYRALRRWLNRIFDAEFDRFMDADFDS
                     PLGLVNSRDAVKDLSRLVALGGFGKLGGQVDRKIRDPRLRRIFTFQALYAGVAPSRALA
                     VYGAIAHMDTSLGVYFPEGGMRTIAESMADAFTEAGGILHLGRTVERLEVSDRRVHTVH
                     TRDGERFDCDAAVLTPDMAVTDSLLRPHTRLRPRPVRTSPSAVVIHGTVSSAVADEWPA
                     QRHHMIDFGEAWKRTFAEITARRGRGRLMSDPSLLVTRPAQTDPSLAFSRDGRIREPLS
                     VLAPCPNLDSASLDWSTLGPPYVREIILTLQERGYTGLVEGFEIDHVDTPQTWLEKGMA
                     AGSPFAASHTFTQTGPFRRKNLARGFDNVVLAGSGTVPGVGVPTVLLSGRLAAERITGT
                     RERASAVGTRASN"
     gene            12834..14411
                     /locus_tag="O4271_RS22925"
                     /old_locus_tag="O4271_22920"
     CDS             12834..14411
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003941737.1"
                     /locus_tag="O4271_RS22925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22920"
                     /product="alpha-(1->6)-mannopyranosyltransferase A"
                     /protein_id="WP_003941737.1"
                     /transl_table=11
                     /translation="MTSSAAATERPWHLRAANFLRTPEGHSALLGFFGAVMITFGGFGA
                     GSVRRQDPLLESMHLSWLRFGHGSILSAAIVWIGVLCMIAAWVRLGRSTLRGDVSLRGL
                     RYVVPVWTFPLLFAVPMFSRDAYSYLAQGALLRNGFDPYAVGPVVNPGILLDNVSNVWT
                     TTTTPYGPVHLLLADAIVRLTGENVIAGTMLLRITMLPGLALMMWAVPHLATKLGGNTS
                     IALWLAVLNPLVLIHLIGGVHNEMLMVGLMAAGIALALERKHLFGIGLIALAVAIKATA
                     GVALPFIVWIWMIHEREDAAAAGREPASPIRSFVKTAGAGFAVFVAVLGSTSLIAGVGL
                     GWTTALSGSAKIINWLSLPTIVAHIGTMATSWFAGDHFNDILEVSRTISAVVLIAIIAV
                     VWWRYRKTERDAVMGIVIVMVAIVVLSPAALPWYYSWPLAVAAGFAMSPTTLAVLTGLS
                     TWLMLVFQPDGSIGLYTFPHVALAIVAAVIAAMSLQTEDPLRLRGRKHEKPIEMTSAAS
                     APSTSGSA"
     gene            14422..15366
                     /locus_tag="O4271_RS22930"
                     /old_locus_tag="O4271_22925"
     CDS             14422..15366
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730072.1"
                     /locus_tag="O4271_RS22930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22925"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_269613537.1"
                     /sec_met_domain="phytoene_synt (E-value: 7.1e-91, bitscore:
                     298.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.1e-59,
                     bitscore: 194.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALPASYEFCEDVTREHGRTYFLATRLLPEPRRRAVHALYAFAR
                     VVDDVVDEPSGPHERGTVLADVERAAVTALDNPTATGGFPSTVPLDLTRVLPAFADAVK
                     TFDIPRAYFDAFFESMRMDAPDTAKFRPVYDTMDELSEYMYGSAVVIGLQMLPILGVSV
                     PQQEAVVPASNLGEAFQLTNFIRDVGEDLDRGRLYLPAGEFAAFGVDIEMLEHGRRTGT
                     VDVRVKRALAHFIAVTRGRYRSAESGIPMLDRRVQPSIRTAFVLYGAILDQVERADFRI
                     LHRRVSVPGRTRLRVAAPGLVRSATYAAKNRMR"
     gene            complement(15387..15755)
                     /locus_tag="O4271_RS22935"
                     /old_locus_tag="O4271_22930"
     CDS             complement(15387..15755)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007297456.1"
                     /locus_tag="O4271_RS22935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22930"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_003941747.1"
                     /transl_table=11
                     /translation="MSAIPYCDDVLDSSVSLFQLVDVAKNVGLPVSKVHQLLRDHKIIA
                     VKRHGVLGVPEVFFGEDGQIVKWLPGLLAVLHDGGYTDVEILRWLFLADDSLPGRPVDA
                     LHGDLAREVIRRAQAMAF"
     gene            16059..18122
                     /gene="pknB"
                     /locus_tag="O4271_RS22940"
                     /old_locus_tag="O4271_22935"
     CDS             16059..18122
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730071.1"
                     /locus_tag="O4271_RS22940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22935"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_211921181.1"
                     /sec_met_domain="Pkinase (E-value: 2.9e-50, bitscore:
                     165.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGEMLERRYRVDAPIARGGMSTVYRGLDTRLDRPVAIKVMDPQF
                     AGDPAFLTRFEFEARAVARLKHPALVAVYDQGSDRNHVFLVMELVDGGTLRELLRERGP
                     MPPHAVAAVVAPVLDALAVAHRAGLVHRDVKPENILISDTGEVKIADFGLVRAAAAATT
                     TSNSVILGTAAYLSPEQVTSGIADTRSDVYSTGVLMFELLTGTTPFTGDTSLSIAYQRI
                     HDDVPRPGSRIPGVPAQFDRLVAEATHREPAHRFADAGEMAAALRSVSEQLELPAYRVP
                     APRRSAQHQSAQVAPARPQPAPAPPTEVHPNSAARPNPAATTVLASGVAPAVAATTALG
                     TGSPPPGGIQHTRAVTAQTARPATVDGDSDFDDGSDFGDDHPGHDDPHAHFVEARRKSR
                     RATLIWLLVIAVLALALGFGGWWMGSGRYTAVPSIDGLTKDTAVTALQDAGLSPDVQGQ
                     YSDAQPIDTVIGTDPASGSRVTKGSTVALLTSLGRPTVPPIPAGGDVSALGAQLADRTL
                     VAVDGGDTFSSKIPIGGVAALDPAPGTEVAVGSSVKVITSKGSPPVDIPDVKGMSENAA
                     RAALDKVGISVSTTRTTFDDAVEGGSVIGTDPAVGSSVNAGTSVVLLISDSVKVPSLIG
                     RSVSSAREELGRLGLEITVRQLTQNDSSVIISQSVKNDLVAKGTDISVVAIP"
     gene            18150..18578
                     /locus_tag="O4271_RS22945"
                     /old_locus_tag="O4271_22940"
     CDS             18150..18578
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003941706.1"
                     /locus_tag="O4271_RS22945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22940"
                     /product="protein-tyrosine phosphatase family protein"
                     /protein_id="WP_054187279.1"
                     /transl_table=11
                     /translation="MATWEPESIGILDLPSGRSIRGRGLRNPLPSGPLPTFGVYLTGKE
                     PPDTEWESEWVRWRDFWLPSDPDALRRALHEVWVRSETERVEIACGGGYGRTGTALAAL
                     AVMDGVPSEDATAYVRARYSPRAVEMPWQRRFVTRFTQ"
     gene            complement(18662..20047)
                     /locus_tag="O4271_RS22950"
                     /old_locus_tag="O4271_22945"
     CDS             complement(18662..20047)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016933765.1"
                     /locus_tag="O4271_RS22950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22945"
                     /product="3-deoxy-7-phosphoheptulonate synthase class II"
                     /protein_id="WP_007730070.1"
                     /transl_table=11
                     /translation="MNWTVDVPIDRLPELPPLPAGLRKQLDEALAKPAAQQPSWPADQA
                     AAMRTVLESVPPITVASEVEALQERLAQVARGEAFLLQGGDCAETFADNTEPHIKGNIR
                     TLLQMAVVLTYGSSMPVVKVARIAGQYAKPRSADIDSLGLKSYRGDMINSLVADEAVRA
                     HDPSRLVRAYANASAAMNLVRALTGAGMADLHKVHDWNREFVAASPAGARYEQLAAEID
                     RGLQFMNACGVTDPSLHQAQIFASHEALVLDYERAMLRLDNDSDHPKLYDLSAHFLWIG
                     DRTRQLDGAHIAFAELVSNPIGLKIGPSTTPEMAVEYVERLDPTNKPGRLTLISRMGNG
                     KVRDLLPAIIEKVQATGHQVIWQCDPMHGNTHEASTGYKTRHFDRIVDEVQGFFEVHNG
                     LGTHPGGIHVELTGENVTECLGGAQDISDLDLGGRYETACDPRLNTQQSLELAFLVAEM
                     LRG"
     misc_feature    complement(20080..20095)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.66"
                     /tool="antismash"
     gene            complement(20138..20629)
                     /locus_tag="O4271_RS22955"
                     /old_locus_tag="O4271_22950"
     CDS             complement(20138..20629)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012688083.1"
                     /locus_tag="O4271_RS22955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22950"
                     /product="polyadenylate-specific 3'-exoribonuclease AS"
                     /protein_id="WP_003941683.1"
                     /transl_table=11
                     /translation="MRYFYDCEFIEDGRTIDLVSIGVVCEDGREYYAVSTEFDPARAGS
                     WVRKNVLPKLPQPSSPLWKSREKIRDDLLKFFVPRPMVVPELWAWVAAYDHVALCQLWG
                     DMTELPQSMPRYTRELRQFWEDNGSPALPSAPADAHDALADARHNLVKFDAISAARSLR
                     "
     gene            complement(20696..21502)
                     /locus_tag="O4271_RS22960"
                     /old_locus_tag="O4271_22955"
     CDS             complement(20696..21502)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003941692.1"
                     /locus_tag="O4271_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22955"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_003941692.1"
                     /transl_table=11
                     /translation="MWYWLFKYVLLGPILWLLGRPTVKGHENIPTDGAAILASNHQAVL
                     DSFYLPLRVNRRITFLAKSEYFTGSGLKGAFQKWFFTAVGQVPIDRTGADAAQDALNAG
                     LKVLGSGSLLGIYPEGTRSPDGRLYKGKTGMARLALESGVKVIPVAMVGTDKMNPIGSR
                     MWRPAKVTVIVGEPIDFSRFEGMGGNRFVERAVTDEVMYKLMKLSGQEYVDIYAASLKN
                     QAPTKPEAAVDVPAEGGESVVDLVASAESKESAKSDKDSLPDAQAS"
     gene            complement(21597..22637)
                     /locus_tag="O4271_RS22965"
                     /old_locus_tag="O4271_22960"
     CDS             complement(21597..22637)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748895.1"
                     /locus_tag="O4271_RS22965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22960"
                     /product="ROK family protein"
                     /protein_id="WP_020969875.1"
                     /transl_table=11
                     /translation="MSARRLKAVSDSTMDDILTVGIDVGGTSIRASVVDVDGQVLEMIQ
                     APTPQSARALEDGLDRVVRELVTRHEVSAVGLAVAGFITSDRSSVRFAPHLPWVDAPVG
                     SDLSKRLGLPVVLEHDANAAAFAEHRFGAAAGGRNVVMVAIGTGIGGALLINGELYRGS
                     HGVAPELGHIQVVPGGRQCACGKRGCWERYCSGTALVDTAIELLAADPAASTVLAREVA
                     VDPGSLTGRRIANAAQDGDPLALATIAEFTRWLAVGLAMVGDVYDPDLVVIAGGVASSA
                     PLFLDDAREQYATLLTGAKHRPLARIRSAQLGEAAGMVGAAALARSVVPQDLGGVDGAG
                     TTSAGL"
     gene            complement(22762..23157)
                     /locus_tag="O4271_RS22970"
                     /old_locus_tag="O4271_22965"
     CDS             complement(22762..23157)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748896.1"
                     /locus_tag="O4271_RS22970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22965"
                     /product="hypothetical protein"
                     /protein_id="WP_042453569.1"
                     /transl_table=11
                     /translation="MSEEHERLVAEFRALAETVLTRLEPVLQKAAAATADVASDSASTD
                     TQPVFTGCSWCPVCALAALVRGEHHELLAFLAGQAAAFLALLREILDEFLGGPSGPDRG
                     PDGGPTTPGAERTRTAAFVPINVTVKD"
     gene            complement(23154..24404)
                     /locus_tag="O4271_RS22975"
                     /old_locus_tag="O4271_22970"
     CDS             complement(23154..24404)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1157: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730068.1"
                     /locus_tag="O4271_RS22975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22970"
                     /product="ArsA-related P-loop ATPase"
                     /protein_id="WP_204856025.1"
                     /transl_table=11
                     /translation="MPEQRSRVQLFVGKGGVGTTTLAAATAVSAATDGARVLLVSIDQA
                     GSLADVLGVPNPRTTTSLTERLDVRQLDTSALLEDKFRGLSGLIDAAGTFGAGDHEHGS
                     SFEGLEPEELTGSLGIQDMLGLAEIVDLSDSGDYDVVIVDCPAAAEALRILGSPSMVSE
                     YLERLWPRHRRMVAVTGTDMRLLLLVSVVERVLASVDRIAVHLSDRENTGVRVVTSADG
                     VSVAATRRTLSGLALAGLRVDGIVVNNLVPQFNSPAGKGVDDSPAAQWLASIRAAQALV
                     VDELRGSTDGMSVTTVERACAEPVGLAALGEIAATFEGGAGTDSGTVGTADNIVVSLES
                     GTGVDSVYVMRMYLPLVDPSSLSLGRVEDDVLVGADGVRRRVRLASVLRRCVVNGAELD
                     GSYLIIRFSPDPAVWPV"
     gene            complement(24405..24842)
                     /locus_tag="O4271_RS22980"
                     /old_locus_tag="O4271_22975"
     CDS             complement(24405..24842)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (8-144). E-value:
                     5.9e-17. Score: 54.3. Matches aSDomain:
                     nrpspksdomains_O4271_RS22980_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005247694.1"
                     /locus_tag="O4271_RS22980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22975"
                     /product="SRPBCC family protein"
                     /protein_id="WP_269613543.1"
                     /transl_table=11
                     /translation="MAEKTKGLISIDAPADAVMDVIADFERYPEWVAAAKSVEVTAPGQ
                     GGRADRVRFVLDAGMVKDTYELQYSWAPNGMAVSWELISGEIQKSQFGSYTLEPGLNGT
                     TSVTYELTVDLTIPMIGLFKRKAEKIITDTALKELKKRVEG"
     aSDomain        complement(24411..24818)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS22980_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="5.90E-17"
                     /label="O4271_RS22980_Polyketide_cyc2.1"
                     /locus_tag="O4271_RS22980"
                     /protein_end="144"
                     /protein_start="8"
                     /score="54.3"
                     /tool="antismash"
                     /translation="ISIDAPADAVMDVIADFERYPEWVAAAKSVEVTAPGQGGRADRVR
                     FVLDAGMVKDTYELQYSWAPNGMAVSWELISGEIQKSQFGSYTLEPGLNGTTSVTYELT
                     VDLTIPMIGLFKRKAEKIITDTALKELKKRVE"
     misc_feature    24808..24821
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.45"
                     /tool="antismash"
     gene            complement(24906..25292)
                     /locus_tag="O4271_RS22985"
                     /old_locus_tag="O4271_22980"
     CDS             complement(24906..25292)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-55). E-value:
                     4.7e-08. Score: 25.5. Matches aSDomain:
                     nrpspksdomains_O4271_RS22985_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748899.1"
                     /locus_tag="O4271_RS22985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22980"
                     /product="hypothetical protein"
                     /protein_id="WP_003941776.1"
                     /transl_table=11
                     /translation="MSSIQVADQTFIAAPPERVAELLSSRAQWRRWFSDLELEVREDRG
                     PAGFRWGVSGQLVGTMEVWLEPVMDGTIAHYFLHCEPVGVSPSDLATLDLAGMNRKRRV
                     DGKVMSFQLKRELEAGRAAGVAPD"
     aSDomain        complement(25128..25280)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS22985_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.70E-08"
                     /label="O4271_RS22985_Polyketide_cyc2.1"
                     /locus_tag="O4271_RS22985"
                     /protein_end="55"
                     /protein_start="4"
                     /score="25.5"
                     /tool="antismash"
                     /translation="QVADQTFIAAPPERVAELLSSRAQWRRWFSDLELEVREDRGPAGF
                     RWGVSG"
ORIGIN
        1 tctcggtccg cgtgccggaa gaatcgacag tcgacttcac gatccgcgga ggaattcgca
       61 cgccgtcgtt ggcaatggcc tggtacatcc cggtcatctg cagggttgtc atcgagagac
      121 cctgcccgat cggcaggttc gcgaaggttc cgccggacca ctggtcgcga ctcggaacgc
      181 tgcccgcgct ctcgccggga agtccgacgt cggtgcgttg tccgaggccg aacctgttca
      241 gcatgtctgc gtagcgatcc tcgcccactc gctgagcgag catcaaggtg ccgacgttcg
      301 aggactttcc gaatacaccg gtagaggtgt acggggccac accgtgatcc cacgcgtcct
      361 tgactgtggc accggacatc gtgatgctgc ccgggacctg cagaacttcg tccggagttg
      421 tcttaccgtc ctcgatggcc gctgctgcgg tgacgatctt gttcaccgat ccgggctcga
      481 acggcgtact gaccgacgga ttgcccattt cggctgtcgg cgcgttcttg tcgatgccga
      541 ttgcggggtt gaaggtgctg tcgttggaca tggccaacac ctgtcccgtc ttggagtcca
      601 tgaccacaac cgaagcgttc tttgcgcccg acttgtcctt ggcgatctgg acctgctgct
      661 gaacgtagaa ctggaggtcc gaatcgatgg tcagctcgac acccgaaccg ttgactgccg
      721 gttgcttgtc acgccagctg ccggggatca cagcgccgtc ggaaccgcgg tcgtacgttt
      781 cggatccatc ggttccggcg agcgtggagt ccatcgaatc ttcgagaccg agcaaaccgt
      841 gcccgtccca gccggtcgcg ccgacgagat tcgcggccag agagccaccg gggtactcgc
      901 ggatgtcctg acgctcgagg ccgacctccc ggaacttgtc cgagatctcg gcagcaaccg
      961 ccggatccac gctgcgcgcg aggtacgtga aagtctcgtt gctgttcatc ttctgaagca
     1021 gatctttttc cggaacggta tcgccgagct tggcgtggat tccggcggcg atctcggcga
     1081 ggcgatcgct cacttccggc gcctgcttgt caccctcggc gccctgctcg atgctcttgg
     1141 cgcgcgcttc ctcgagttcc ttgcgtaccc gcaccggctg gaaagtcagc gccttggctt
     1201 ccatggtgaa ggcgaggggg tttccgttgc gatcggttat cgagccacgt acagccggat
     1261 cgacctgcgt cgtggttcgt tgattggcag attccgcagc cagactcggc gcgtcgattc
     1321 cctgaatcca caagagctgc aatgccgcaa cggcgagcgc accacacatg gtgatacgac
     1381 cgactcgctg acgaaacgga aatgaggcgg tggccgagcg gcgcggacgc cgaccggggt
     1441 tgttacggga gttctgactc accgacgttc ctcaggcgga gcaggcaccg ccgtcgtggt
     1501 ggcgggtgct gtcgtcgtgg ggatcacagg aaccaattgt tcactctgcg cgaggtttcg
     1561 cgtgttattc ggaacgctcg gcgtggctcc gggagcaacc ggcgttgtgg tgcgcggggg
     1621 tgtcgcagtc ggtgcgggca ccgatgtggg cgcatcgagc ggcggcatag ctccggcagt
     1681 cgcgggagtc ggcgttccga cgacctcgac cgaaccgtcc ggatgaacta ccagtcgtgc
     1741 agggtccttg gcggggacca tgccgagagc gcttgcctga tttgccaact ccggagccga
     1801 gttacgcgac tggaagtcac gttcgagcgc tgctttctgc tcgaccaaag actggttgta
     1861 tgcacgtgca tcactgagtt ggtacgaatc ctcggcagcg cgagtggtca gcagcagagt
     1921 caccgcgaga ccgatggaca gaagtccgat gacggaggcg acgaacggca ctctcccctt
     1981 gagcatcgcc cgaggagaga tagacgggcc ggcagcagcg acagttccgg tccggcctgc
     2041 cgcccgtgcg gtgcgcttgt cgtatgcacg ttgcgctgca ccggatttgc cctgacgact
     2101 catgtccgcc tcctggaaat gcgttctgcg gcacgcaaac gcaccggagc tgatcgtggg
     2161 ttctcttcga tttcctgctc tgacgcacgt tctgcgccac gggtgagaat gcggaactcc
     2221 ggtcccatac ccggcaactc gaccggtagt ccttcaggac tggtggactt cgagcgggga
     2281 accaactccg ccttcacaac tcgatcctcg agcgactggt aggacatgaa caccactcgc
     2341 ccaccgactg ccagtgcgtc gagcccggca ggaacggctg cacgaagcga atccaactcg
     2401 gcattgactt cgatccgcag cgcttggaag gtgcgcttgg ccgggtgtcc ccccgtacgc
     2461 cgcgtggctg ccgggattgt tcggtacagc aattcgacca gagctgcact ggtggtgaag
     2521 ggttcacgct cacgctgccg aaggatctcg gacgcaatct ttcccgcgaa ccgttcttcg
     2581 ccgtacgtgc tcagaatgcg agcaaggtcg ccgtgactgt aagtgttcag gacctctgcc
     2641 gcggtcagcc cgaccgtctg atccatccgc atgtcgagag gagcgtcgat cgagtacgca
     2701 aaacctcggt cggcttcgtc caactgcatc gacgacacac ccagatcgaa aaggatcgcg
     2761 tgaaccgact ccgtcgacgg cagacctgcc tgttcgagcg cgtcctcgat cccgtcatac
     2821 gtggtgtgca cgaacgtcgt tcggtccgcg aatggcgcca gacgctctga agcgatccgg
     2881 agtgcgttgg tgtcgcgatc gagaccgatg aggtgaaggc ccgggtactt gcccaggaag
     2941 aattcggagt ggccaccgag ccccaacgtc gcatcgatca tgtatgcgcc cgctccaccg
     3001 tcaccgacgg cggtgatggc agggccgaga agatcgtcgg cgcggtgcag aagtacaggg
     3061 acgtgcgcga agccatcggc atccgagggt tcgttcacct cgtgatccac catgattgct
     3121 ccggctccta ctttcatgat ttccgatgac ttttcgaaaa ggtgctgact ttccgagaag
     3181 gcgatgactg ttcgagaagg cgaatgcttc gaggtccctg cccgaaggag aacctggcgc
     3241 tggggaagtg cgtcagggtc tttccgggca gaggcctcgc ggcattcgcc gggggctctt
     3301 cgcctagacg atctcgctga gagattcgcc tgttgcctgc gaatagtcct cttcgttgtc
     3361 tccgagatac ctctcccagg ctgctagatc ccagatctcg aggtaatcga cggagccggt
     3421 cactacgcat tccttggaca ggtttgcgta acgccgatga tcagccgaga gggtgattcg
     3481 cccctgggca tcggcgtgct gttcatctgt gccggcggcc agggcacgga cataagcccg
     3541 agctgccgga tcattgcgtg gagctgccgc tgcctttcga gcaagcttga cgaactcgtc
     3601 ccgggggtag atggcgaggc tgtgatcctg actcttggtg atcatcaatc ctcctgccag
     3661 ttcgtctcgg aactttgccg gcaacgtgag ccgacctttg tcgtcgagct tcggcgtgaa
     3721 ggtaccgagg aacactcgac acctcctgcg agcttgcgct gaaaccctcc ctatcgagcg
     3781 gatcgtgctt cagctctccg cccgaaccca cagtacccca ctttccccca caaacaagga
     3841 gcacatggtc cctattcagc atcatttgct gataaatagc aggtcagcgc aggtggggag
     3901 acgtggggga aatttgtaac cgtgtcccgg cccacaccgc cgtcagatcg accctttacg
     3961 ccacgatctg ttgctccccc acacaaaatc gcagtacaag cgcggttttc gaatagacgt
     4021 gagcgggacg aggtctggtc gtgcgttgca gttcgaccag ggtggaggaa agtggagggc
     4081 cgagtggagc gaagtggagg aagcccgcgg gcatgccctg aggcagcagg agtggcgagt
     4141 gattcgctcg cacgtcactg attcactcga tggattgccg gcgcacacgt acaacactta
     4201 cagcaacggc gtgtggcggt cggcaacctt ggttgccgac cgccacacgt gtggtcgtcc
     4261 gtgccctgaa gagggcgtca cgtccgaact gcatcactct cgaagtacgc ccgaagaagg
     4321 gcgggagagc tagtcctgct cgaacctgcg tttgaatcga tcttccatcc gcgacgagaa
     4381 tccgccgccg gacttccggc cgcgtccccg cccggatccg ccggcactac ccctacccgg
     4441 cggaccggag ggatgattgc caccttcgga agcggagtcg gcggccggcg cagacttacg
     4501 tccaccaccc cagaggaaca acacccctgc gccgaacatg aacaagaaac cgaacaggct
     4561 gatgatcgga aaaccgcccg gcttgagcgg gagtgcaacc cccgcgatca gcaggaccag
     4621 acccagcacg aatagagccg ctgcttggaa ccgccgtcta ctcgacggag cccgcatacg
     4681 gccgcccctc acattggagg cgaacttggg gtcttcggca tagagagcgc tctcgatctg
     4741 atcgagcatg cgctgctcgt gctcggagag tggcacggta cctcccccgg cactggaagt
     4801 ttggcaacca ccccacggtg tgaggcggcg ggtaatcaag ttggacgatt acctgttttc
     4861 ataatacgag cagtttaggt ctcggaccac caactccggg tacgagttcc gccacaagcg
     4921 tacgtattcg tgccgaaggg ccccgattcg gctccatttg cctgtgcgga ccaggaaatt
     4981 ccccggaaac aactgccgac acggaccatt tgttcacgac gctcgcaaat gctcggacgc
     5041 gtcctgaccg atgaaatctt cgaccgccgt gagaaaacgg ccgacctcgg cgaagaatgc
     5101 gtcggaatcg gagtccgtga tcacgatcga cacgccggtt tccacggccg cacgcgtagc
     5161 ggaccaccct gcgaagaatt tcgaccacgc tccgaacgcg ggcgctgcgg cgtccatcag
     5221 aacccacgcg tttccacttc gcttgcgctt cgagccggca ccggcaggag ctgcggccaa
     5281 cactgccccg gcaccacgta gggccgccag gtaggcacac cggaaccggt cggcaggatc
     5341 gcccgcccca atcgcttcct ctaaaagcgc atccgccttc cggagcagcc cccacgccac
     5401 accggacttt cccactcgag cagtgcggtg gctggcgtcc gtcgcgccga aggaccgcct
     5461 cgccgacatt ggcaatcgag aaattgcggc atccgacgga ctcgacaact cggcaggaag
     5521 agttcgttgg cacttcacac gttcaggctt cacacgctcg gacatcgggg cacctcctgc
     5581 accgtgagga tccaagacca ggtgggccgg agatgcccgc ttcccttcgg gcatctccgg
     5641 atcacccaca tcgaacatct gttcgaccta ttcaatataa ctgcacccac cgacacgccg
     5701 tcaagagaag aggtgagacc ggtcgacccg cagatcgcct ggacaccaca tacggtcgac
     5761 ctcgatcgcg cagaattcgc gagtcgactc cacgaggcac tggccgtgta cgtcaccgcg
     5821 atggactatc cgcgaggaac cgagttccat cgcgcaccga tgtggcagga gcacgcgaac
     5881 cggccaggct ggaaggccgt cggcgcattg gcggttcctc agcaaccgtc acacgaaaat
     5941 ctgccgctgg tggggatcgc ttacgggtat cgcgggagcc cggaccagtg gtggcatcaa
     6001 caggtactgc acgggcttcg gcgctcgggt cgtccccaga gcgagatcga cgcgattctg
     6061 agcgactact tcgaactcac cgaactccac gtgcatccga acggacaagg tcaccggttg
     6121 ggcgaatcgc tcttgcgtca cctcctcgtc gatcgacccg aacgcagtgt tctgttgtcg
     6181 acacccgagg tgtacgacga ggacaaccga gcctggcggc tgtaccgtcg cctcggcttt
     6241 cgtgacgtgc tccgcagatt tcgttttgcc ggcgacaacc ggccgttcgc agtcctcggc
     6301 cgtggactgc cgctgtgagc gcgcttctcg acgccgtcgt cgtcggctcc ggacacaacg
     6361 cgctcgtatc ggccgcctac ctcgcacgcg agggttggtc ggtcgaggtt ctggagaagg
     6421 acacggttct cggcggcgcc gtctcgaccg tcgagcgatt tcccggatac atggtggacc
     6481 gggggtcgtc ggcacacctc atgatccgac acagcggcat catcgaggaa ctcggactcg
     6541 gcgcgcacgg actgcgctac atcgactgtg acccgtgggc gttcgcgccg cccgccccgg
     6601 gcaccgacgg gccgggcatc gtgtttcacc gcgacctcga cgcaacctgc tggtccatcg
     6661 aacgagcatg cgggacaaag gacgccgact cctaccggcg attcgtcgcg gtctggtcgg
     6721 agcgcagtcg acatgtcatg aaagcgtttt ccgcaccgcc caccggatcg aacctgatcg
     6781 gtgcgttcgg aggtctcgcc accgcacgcg gcaacagcga actgtctcgg cagttcctcg
     6841 cgcctggcga cgcactgctc gacgagtatt tcgacagtga ggcactcaaa gcagcgcttg
     6901 cgtggttcgg cgcccagtcc gggcctgcga tgtcggaacc gggaaccgct ccgatggtcg
     6961 gcttcgcggc cctcatgcac gtcttgccgc cagggcgagc agtcggtgga agcggcgcac
     7021 tgagtgctgc gttggcctcc cggatggctg tcgacggcgc cacggtcgcg ctcggtgacg
     7081 gcgtgacgtc gatccgtcga aactcgagtc actggaccgc cacaaccgag agcggtcgag
     7141 aagttcacgc tcgcaaggta atcgccgggt gccacatcct gaccacgctc gacctcctgg
     7201 gccgaggggg cttcgaccga accacgctcg atcactggcg gcggaaaatc agggtcggcc
     7261 ccggcatcgg cgcggtactt cgactggcga catccgcgct tccgtcgtac cgcggcgacg
     7321 ccacgacacg ggaaagtacc tcgggattgc aattactcgt ctccgatcgc gcacacttgc
     7381 gcactgcaca cggcgcagca ctggcggggg aacttcctcc tcgccctgcg gttctcggaa
     7441 tgagtttcag cggaatcgat cccacgatcg ccccggcagg tcggcatcag gtgacactgt
     7501 ggtcgcagtg gcaaccgtat cgcctcagcg gacatcgcga ttgggcatcg gtcgccgagg
     7561 cggaggccga ccggatcgtc ggcgagatgg aggctttcgc acccgggttc gccgattccg
     7621 tcctcgaccg gttcattcag actccccggg acatcgagtc ggaattgggg atgatcggcg
     7681 gaaatgtcat gcacgtcgag atgtcactcg atcagatgat gttgtggcga ccgcttcctg
     7741 aactgtccgg ccatcgtgtt ccgggagcag acgggttgta tctgaccgga gcatcgactc
     7801 atcccggtgg cggtgtgtcc ggagccagcg gtcgcagtgc ggctcgaatc gcactgtcgg
     7861 acagccgccg gggcgcgact cgtcgttgga tgcgtcgttc gagcaggtcg tgaaggtcac
     7921 ccgccgaact tcacccgccg acacgccccc gcctcgatga ctggctacgc cacggctggc
     7981 acgatgacca ctgtgcaaca gtccaccgat cccgccgcca agccgaccag tcggaaacgt
     8041 ttcctgacgg ttgccgcgct cgccctcatg cttgttccct tgcttgccgg gtgcatccgc
     8101 gtgcaggtgt cgatgggagt gtccgcgaac gatcgtgtga ccggacaggt ggtagctgcc
     8161 gctattccgg cgaacgaggc ggacaagggt ccgcagctga ccccaccttc gtcgctggag
     8221 gacaagatac gggttcagga gtacaagaag gacgggtacg tcggcagcca ggcgttcttc
     8281 agcgacttgt ccttcggtga cgtcacccaa ctgggctcca tgtacgccga ggggtccggg
     8341 tcgttccaga tcaccctcaa gcgatccggg gacaccgtca cgctcgacgg caaggcagac
     8401 ctgaagacgg ttccaactca gggcgccgac gtccaggtca gcatcgcctt cccggcacgg
     8461 gtcggcacga ccaacggaac acgagacggc gattcccggg tgtcgtggac cttgcccgcc
     8521 ggcgaggtgt cgacaatgcg cgccgaggtc aactacgcgg acccaagcac ccgaagcttc
     8581 gccgggtggg caggaatcat ggccgggctg gcgctcggtg tcgcgattgt cgtcggtgcg
     8641 atggcctgga tggcgcgcaa tcgagcaccg atcaagcgcg cgcccgccgc gaaagcaccg
     8701 gtcatgaaga cgcctgtcac gaaatcacct gccagcaagc aagctgacaa caggaatccg
     8761 aaaaacacca cgaagtagcg cctggcgatt gccccactcg attgccccac tcgattgtcg
     8821 tcgagcgggg caaccggaga tcagacggct tgtgctgtcc cgaccgaagt gtcgggagtg
     8881 agaccgagtc gctcgaggac ctcactggtg gcgcgcgcaa agttcaacgt gatgaagtgc
     8941 aggcacggag cgccttcggc gatcaaccgc tcacccatct cggtggccag atcgatgccg
     9001 agttcgcgga ccgctgcacg gttctcgtcc ggaccgcttc cggccgcggc gtcgaatcga
     9061 cgctcgagag cggggggcaa cgacgagccc gagagctcga gcatgcgccg caccgagcgc
     9121 agcgacgtca ccggcatgat ctccgggatg atcggcttgg cgccctgttc tgcgtcgtac
     9181 gcactcaccc ggtcacgaag acgcaggtag tcctccacgt cgaagaacat ctgtgtgatc
     9241 gagtactcgg cgccggcacg caacttcgac accaggtact tcgtgtcgta tgccaagtcc
     9301 ggagcgcggt agtgcccctc ggggaacgac gcgacgccga cgtggaagtc gcccaggtca
     9361 cggaccatcc gcacgagttc ctcggcgtac tcgacgcctt cgggatgctt cttccattcg
     9421 ccgagcggat cgccgggcgg atcgccgcgc aatacgagga tgttgctgat cccacgatcg
     9481 gcgtaggcac cgaccatggc gcgaagctct tcggtgctgt gtgagacagc agtcaggtga
     9541 gcaaccggca gcagggtcgt ctcttcggca agttcgccgg tgacacgcac cgtacgatcg
     9601 cgcgtcgagc cacctgcgcc gtaggtcatc gagacgaacg ccggtccgag ccgctcgaag
     9661 gtacgcaccg cacgccacag gcgcgcttcg gcgtccgcgt cacgcggcgg cgaaaactcg
     9721 accgagaacg gaatacggct acctgtcgag gaagcgatcc gatcgacgat cgacggtgtt
     9781 cgggtggccc acccctcgct ggagcggccc ctgactggat cgaatgtcac cggtcaagca
     9841 tatgttttcc agctgcaaac aagctcatcg cccagtactg cgtatcccga atgtcaggat
     9901 cgcgcagttc acggcccgac ccgccgttga ttccaacccc tactaagctg ggccccaagc
     9961 tcgcttccgt gtaaccatcc ggcgcgagaa cataccgatc ttggaggcca ccctgtccgc
    10021 aggaaccgcg cgcgttggac agagttcgac caacaccgca ccgcatccga cctcactcga
    10081 actgccaggt ctgttcgaag cagcgctccg cgacttcttc gcttcacgcc gcgaactcgt
    10141 ctcgaacatc ggcggtggat acgaggaggc cgtcagcacc ctcgaggcct tcgtcctgcg
    10201 cggaggaaag cgcgtccgac cgtcgttcgc ctggacggga tggctcggcg ccggaggcga
    10261 cccgaacggt aaggacgcag acgcggtgat tcgtgcgtgc gccgccctcg aactggtgca
    10321 ggcctgcgcg ctcgtccacg acgacatcat cgacgcatcc acgaccaggc gcggcttccc
    10381 gaccgttcac gtcgaattcg aggaccagca ccgagacgag gagtggagcg gcgattccgc
    10441 gcacttcggc gaggccgtcg ccattcttct cggcgacctg gccttggcct gggcggacga
    10501 catgatccga gaatccggga tcagccccga ggcggccgca cgtgtcagcc cggtctggtc
    10561 ggcaatgcgc accgaggtgc tcggtggcca attcctcgac atcagcaatg aagcccgagg
    10621 cgacgagacc gtcgaggcag ccatgcgggt caaccgctac aagaccgccg cgtacacgat
    10681 cgaacgccca ctgcacctcg gcgccgcgct gttcggtgcg gacgccgagt tggtcgatgc
    10741 ctaccggacc ttcggcacgg acatcggtat cgccttccaa cttcgcgacg acctgctcgg
    10801 tgtcttcgga gatccgtccg tcacgggcaa accgtcgggc gacgatctca tcgccggtaa
    10861 gcgaactgtc ctgttcgcga tggcgcttgc ccgcgccgac gccgcagatc cggcggcagc
    10921 agaactgctc cgcaacggaa tcggcaccca gctgaccgac accgaggtcg acactctgcg
    10981 ccaggtgatc accgatctgg gcgccgtcaa cgacgtcgaa acgcagatcg acaccctcgt
    11041 cgaggcagct gcgaacgccc tcgactcgag cacggcaacg gcagagtcca aggctcgcct
    11101 gaccgacatg gcgatcgcgg ccacgaagcg aagctactga ccgtggcaca cgtgcaccgc
    11161 actcgaaccg tcagctcgcc gaccgatcga gtcgtgatcg tcggcgcggg acttgccgga
    11221 ctgtctgcgg ggttgtatct gcgtggcgcc ggccgcgacg tcacgattct cgagagcaac
    11281 agctcggtcg gtgggcgagt cggtgtctac cagggcaatg actacagcat cgacaatggc
    11341 gcaacggtgc tcacgatgcc cgaactcgtc gaagacgcgc ttgccgccgt cggtgccgac
    11401 ccagcctcga caaaccccaa attcgttgtg cacaagctcg atccgacgta ccacgcgcga
    11461 ttcgcagacg gcaccgctct cgatgtccac gccgatccag aagacatggc tgccgaggtc
    11521 tcccgtgtct gcgggccgga agaagcgcag cgataccgtg cgttgcggcg atggctgaac
    11581 cggatcttcg acgcggaatt cgaccgcttc atggacgccg acttcgattc tcccctcgga
    11641 ctggtcaatt cgcgtgacgc agtcaaagat ctgagccggc tcgtcgcact gggaggattc
    11701 gggaaactgg gcgggcaggt ggatcgcaag atccgcgacc ctcgcctccg gcggatcttc
    11761 accttccaag cgctgtatgc gggcgttgct ccgtctcggg ccctcgcggt gtacggggcg
    11821 atcgctcaca tggacacctc actcggcgtc tacttccccg agggcgggat gcgcacgatc
    11881 gccgagtcga tggccgacgc cttcaccgag gccggcggaa ttctgcatct cggccgcact
    11941 gtcgaacgcc tcgaggtgag cgatcggcgc gtgcacaccg ttcacacacg cgacggcgag
    12001 cgcttcgact gtgacgccgc cgtcctcact cccgacatgg ccgtcacgga ctcgctgttg
    12061 cgcccgcata cgcgattgcg tccgcgcccg gtgcgtacat cgccgtccgc tgtcgtgatt
    12121 cacggcactg tttcctccgc ggtcgccgac gaatggcccg cgcagcgaca ccacatgatc
    12181 gacttcggcg aggcgtggaa gcgtaccttc gccgagatca cggcacgccg cggccgcggg
    12241 cggctgatga gtgatccgtc actgctcgtc acccgaccgg cacagaccga tccgagcctg
    12301 gccttctcgc gagacggccg aatccgtgaa ccgctgtcag tcctcgcgcc gtgtccgaat
    12361 ctggacagtg caagtctcga ctggtcgact ctcggcccgc cctacgtgcg cgaaatcatc
    12421 ctcacgctgc aagaacgtgg ctacacggga ctggtcgaag ggttcgagat cgatcacgtc
    12481 gacaccccgc agacctggct cgaaaagggc atggccgcgg gtagcccgtt cgcggcgtca
    12541 cacaccttca cccagacggg gccgttccga cgcaagaacc tcgcccgcgg cttcgacaac
    12601 gtcgttctcg ccggatcggg aaccgttccg ggggtgggag taccgaccgt tctgctgtcc
    12661 ggacggctcg ccgccgaacg tattaccggt acacgcgagc gagccagcgc ggtgggcact
    12721 cgtgcgagca actaaactag cccctcgtaa ccgaccattc atccacgatt caccgactcg
    12781 ggcgctgcat gcgccgatcg acaccgatct cctcggggga ggaacctgca ccgatgacgt
    12841 cctctgccgc agccactgaa agaccgtggc acctaagggc cgccaatttc cttcggactc
    12901 ccgaaggtca cagtgcactg ctcggtttct tcggcgcagt catgatcact ttcggcggat
    12961 tcggtgccgg tagcgtccgg cgccaagatc cgctgctcga gtcgatgcat ctgtcctggc
    13021 tccgtttcgg acacggatcg attctgtcgg cggccatcgt ctggatcggt gtcctgtgca
    13081 tgatcgccgc ctgggttcga ctgggccgct cgactctgcg cggtgacgtc tcgttgcgcg
    13141 gcctgcgcta cgtcgtcccg gtctggacgt ttccgctgct gttcgcggtg cccatgttca
    13201 gccgtgacgc ctactcctac ctggcgcaag gcgcgttgtt gcgcaacggc ttcgacccgt
    13261 atgccgtcgg ccccgtcgtc aatccgggaa tcctgctcga caacgtctcc aacgtgtgga
    13321 cgacgacaac taccccgtac ggtccggttc accttctcct tgccgacgca atcgttcggc
    13381 tgaccggtga gaacgtcatc gccggcacga tgctgttgcg gatcacgatg ctccccggac
    13441 tcgccctgat gatgtgggcc gttccccatc tcgcgacgaa gctcggcgga aacacctcga
    13501 tcgccctgtg gctcgcagta ctcaatcccc tcgtcctgat ccacctgatc ggcggcgttc
    13561 acaacgagat gctcatggtc ggcctcatgg ccgcaggcat tgcgctcgct ctcgaacgca
    13621 agcacctctt cgggatcggg ctgatcgcgc tcgccgtcgc gatcaaggca accgcaggcg
    13681 tcgcacttcc cttcatagtc tggatctgga tgatccacga gcgggaggac gccgcagccg
    13741 ccgggcgaga accggcgtca ccgatccgat cgttcgtcaa aacggccggc gcaggtttcg
    13801 cggtgttcgt ggcggtactc ggatccacct cactgatcgc cggagtcggc ctcggctgga
    13861 cgacggcact ctccggttcg gcaaagatca tcaactggct ctcgctgccc acgatcgtgg
    13921 cgcacatcgg aaccatggca acctcctggt tcgccggcga ccatttcaac gacatcctcg
    13981 aagtctcccg gaccatctcg gcggttgtgt tgatcgcgat catcgccgtc gtgtggtggc
    14041 gctaccgcaa gaccgagcgc gacgccgtca tgggcatcgt gatcgtgatg gtcgccatcg
    14101 tcgttctgtc ccccgcagca ctcccctggt actactcctg gccactggca gtagctgccg
    14161 gtttcgcaat gtcgccgacg actctcgccg tactgaccgg gctgtccacc tggctgatgc
    14221 tggtgttcca gccggacgga tcgatcggcc tgtacacctt cccgcacgtt gctctggcca
    14281 tcgtcgctgc cgtgatcgcg gcgatgtcct tgcagacgga agacccactg cgacttcgtg
    14341 gacgcaaaca cgagaaacca atcgaaatga cgtcagccgc ctcggcgccc tcgacgtcag
    14401 gatctgcgtg atccgcgtgt catgaacgca ctgcctgcgt cctatgaatt ctgcgaggac
    14461 gtgacgaggg aacacggccg aacgtacttt ctggccaccc ggttgttgcc cgaacctcga
    14521 cgccgcgcag ttcacgcgct ctacgcattt gctcgcgtcg tcgacgacgt cgtggacgaa
    14581 ccctcgggtc cacatgaacg aggcacggtg ctcgccgacg tcgaacgtgc agccgtcacc
    14641 gcactcgaca accccactgc gacaggtggc ttcccgtcga cggttcccct cgacctgaca
    14701 cgcgtactcc cggccttcgc ggatgctgtg aagacgttcg acatcccgcg cgcatatttc
    14761 gacgccttct tcgagtccat gcggatggac gcccccgaca cggcgaagtt tcgacccgtc
    14821 tacgacacga tggacgaact cagcgagtac atgtacggct ctgccgtcgt catcggtttg
    14881 cagatgctcc cgattctcgg agtgagcgtt ccgcagcagg aagcggtagt gcccgcgtcg
    14941 aatctcggtg aggcgtttca gctgaccaac ttcatccgcg acgtcggtga agacctcgac
    15001 cggggacgtc tgtatctacc ggcgggcgag ttcgccgcat tcggggtcga catcgagatg
    15061 ctcgagcacg ggcgcagaac cggaacggtg gacgttcggg tcaagcgcgc gctggcgcac
    15121 ttcattgccg tgacgcgggg gcggtatcgg tctgccgaat ccggcatccc gatgctcgat
    15181 cggcgggtcc agccgtcgat ccgcacggct ttcgtgttgt acggagcaat tctcgaccag
    15241 gtcgagcgcg ccgacttccg gatactgcat cgacgtgtgt ccgttcccgg acgcacgcga
    15301 cttcgagtcg ctgcgccggg tctggtccgg tcggcaacct acgcggcgaa aaaccgcatg
    15361 cggtgagttg tcagaaggcc ggcagctcag aaagccatgg cctgtgcgcg gcggatgacc
    15421 tcacgcgcga gatcaccatg cagtgcgtcc accgggcgcc ccggcaggga atcgtcggcc
    15481 aggaacaacc agcggaggat ttcgacatcg gtgtagccgc cgtcgtgcag caccgccagc
    15541 agaccgggca gccacttgac gatctggccg tcctcgccga agaacacttc ggggacaccg
    15601 agaacgccat gccgcttgac tgcgatgatc ttgtgatcgc gaagcaactg gtgaaccttg
    15661 ctcaccggca acccgacgtt cttcgccaca tccaccagct ggaacaggga aaccgaagaa
    15721 tccaggacat catcacaata aggaatcgcg ctcaccgcga gaagtttatc cggtccggcg
    15781 agcccgctgt gtaccgcccg gtgcagtgct cgaaactgcc gctccgctca ggtcacagcg
    15841 ctctgtgacg ttctcgagac ttccgcgtcg gtatcgctgg ctacgatgga cgggatgcgg
    15901 cgtatcagta accgggattt cgcggtggat gtaaatgggt gccctcactg cgggagccag
    15961 tacgcggtaa acaaccaccc acatgccgac agctaccacc tagaccgcaa gcacgcagat
    16021 cgcaagcacg gaggaatagt cattacggag gtcgagggtt gatcggcgaa atgctcgagc
    16081 gccgctatcg agtggacgca ccgatcgcgc gcggcggtat gtcgaccgtg tatcgaggcc
    16141 tcgatacacg gttggatcga cctgtcgcga tcaaggtgat ggatccgcaa ttcgccggcg
    16201 atccagcgtt cctgactcgt ttcgagttcg aagcccgggc cgtggcccga ctcaagcatc
    16261 cggcccttgt ggccgtctac gaccaaggca gcgatcgcaa tcacgtgttc ctcgtgatgg
    16321 aactcgtcga cggcggaacc ttgcgtgaac tccttcgtga gcgcggaccg atgccgccac
    16381 acgcagtcgc tgcagtcgtg gcacctgtcc tggacgcgtt ggcggtggcg catcgagcgg
    16441 gactggtgca ccgtgacgtc aaacccgaga acatcttgat ctcggacacc ggcgaagtga
    16501 agatcgccga cttcggattg gtgcgtgcag ctgcggcagc aaccaccacc tccaacagcg
    16561 tgatcctcgg caccgcggcc tatctgtcgc cggaacaggt gacgtcagga attgccgaca
    16621 ctcgaagcga cgtctattcc accggcgtgt tgatgttcga acttctcacc ggtacaacac
    16681 cgttcaccgg cgatacgtca ctctccatcg cctaccaacg catccacgac gatgtcccgc
    16741 gcccaggttc acgtatcccc ggtgtaccgg cgcagttcga tcgtctggtt gccgaagcca
    16801 ctcaccgcga gcccgcacat cgtttcgccg acgccggtga gatggcagct gcacttcgca
    16861 gtgtgagcga gcaactggaa cttccggcat accgcgttcc cgctccgcgt cgaagcgccc
    16921 agcaccagag cgcgcaagtt gccccggccc ggccacaacc ggcgcctgcg cctcccacgg
    16981 aggtacatcc gaactctgct gcgcgaccga accctgctgc cacgacggta ttggcgtccg
    17041 gcgtggcccc ggctgtggca gccaccacgg cgctcggcac gggctctcct ccccctggcg
    17101 gtatccagca cactcgcgcg gtcaccgcac aaactgctcg tccggcgacg gtcgacggcg
    17161 actcggattt cgacgacggt tccgatttcg gcgacgacca cccggggcac gacgatccgc
    17221 atgctcattt tgtcgaggca cgtcgtaaat cgcgacgagc caccctgatc tggctgctcg
    17281 tcatcgcggt cctcgcgctc gcgttgggct tcggcggatg gtggatgggc tcgggccgct
    17341 atacagccgt tccctcgatc gacgggctga ccaaggacac tgcggtcacc gctctgcagg
    17401 acgccgggct ctcccccgac gtccagggtc agtactccga cgcccaaccc atcgacacgg
    17461 tgatcgggac ggacccggcc tccggctcga gggttaccaa aggctcgacc gtggcgttac
    17521 tgacttcgct cgggcgtccg actgtcccgc ccattccggc cggcggcgac gtctcggccc
    17581 tgggcgcaca actcgccgac cgcactctcg tcgcggtcga cggcggggac acattcagct
    17641 ccaagatccc gatcggcggc gtggccgcgc tcgacccggc accgggaacc gaagttgccg
    17701 tgggctcctc ggtcaaggtc atcacgtcca aagggtcacc gcccgtagac attcccgatg
    17761 tgaagggcat gtccgagaac gctgcgcgcg ccgccctcga caaggtaggc atctcagtca
    17821 gcaccaccag aacaacgttc gacgacgccg tcgagggcgg tagcgtgatc ggcaccgatc
    17881 ccgcagtcgg gtcctccgtc aacgccggca cctccgtggt tctgctcatc tccgactccg
    17941 tcaaggttcc ctcgctgatc ggccgctccg tctcctccgc acgcgaagaa ctcggccgcc
    18001 tcggcctcga gatcaccgtg cgtcagctca cccagaacga cagctcggtc atcatcagcc
    18061 agagcgtcaa gaacgacctc gttgccaagg gcaccgacat cagcgtcgtc gcaattccct
    18121 gacagtccgc ttcggcctaa tctgaattca tggccacgtg ggaacccgag agcattggga
    18181 tactcgactt gccgtcgggg agatcgattc ggggtcgagg actccgcaat ccacttcctt
    18241 cgggacctct ccccaccttc ggcgtctatc tgaccggtaa agaacctccc gacaccgagt
    18301 gggagtcgga gtgggtccgc tggcgagatt tctggttgcc gagcgatccc gatgcgctgc
    18361 gcagggcctt gcacgaagtg tgggtgcgct cggaaaccga aagagtcgag atcgcgtgcg
    18421 gtggtggata cggccgcacc ggaacagcgt tggccgctct tgccgtcatg gacggagtgc
    18481 ccagtgagga cgccaccgcg tacgttcgcg cacgttactc acctcgcgcc gtcgaaatgc
    18541 cctggcagcg ccgattcgtc acacgattca cgcaatagcg aacgccccca cctgcgcgag
    18601 cgggtgaggg cgtttgccga aaatctatgc cggcgcgaat cagcttcggc gaagcagggt
    18661 ttcagcctcg cagcatctcg gccacgagga acgcgagctc caacgactgt tgggtgttca
    18721 atcgggggtc gcacgccgtc tcgtagcgac cgccgagatc gaggtcggag atgtcctgcg
    18781 cgccgccgag gcactcggtg acgttctcac cggtcagctc gacgtggatg ccacccggat
    18841 gcgtgccgag accgttgtgg acctcgaaga atccctggac ctcgtcgacg atgcggtcga
    18901 agtggcgcgt cttgtacccg gtggaggctt cgtgggtgtt gccgtgcatc ggatcgcact
    18961 gccagatgac ctggtgaccg gtggcttgga ccttctcgat gatcgccggc agcaggtcgc
    19021 ggaccttgcc gttgcccatg cgcgagatca gagtcagacg acccggcttg ttggtggggt
    19081 cgagacgctc gacgtattcc accgccattt ccggcgtcgt gctcgggccg atcttgaggc
    19141 cgatcgggtt ggacaccaac tcggcgaagg cgatgtgcgc gccgtcgagc tgacgagtgc
    19201 ggtcaccgat ccagaggaag tgagccgaca ggtcgtagag cttggggtga tcgctgtcgt
    19261 tgtcgagacg cagcatcgcg cgctcgtagt cgagaaccag agcctcgtgg ctggcaaaga
    19321 tctgtgcctg gtgcaggctc ggatcggtga cgccacacgc gttcatgaac tgcaggccgc
    19381 ggtcgatctc ggctgccagt tgctcgtagc gtgcgcccgc gggagacgct gcgacgaatt
    19441 cgcggttcca atcgtgcacc ttgtgcaggt cggccatgcc ggcgccggtg agtgcgcgaa
    19501 ccaggttcat cgcggcgctg gcgttggcgt atgcacgcac cagtcgcgaa ggatcgtggg
    19561 cgcggactgc ctcgtcggcg acgagcgagt tgatcatgtc gccgcggtag gacttcagac
    19621 ccaacgagtc gatgtcggca gagcgcggtt tggcgtactg gccggcgatg cgagcgacct
    19681 tgacgaccgg catcgaggaa ccgtaggtga gcacgacggc catctgcagc aacgtgcgga
    19741 tgtttccctt gatgtgcggc tcggtgttgt ccgcgaaggt ctcggcgcag tcaccgccct
    19801 ggagcagaaa tgcctcacca cgcgcgacct gcgcgagacg ctcttgcagc gcctcgactt
    19861 cgctggccac cgtgatggga ggcacgctct cgagcacagt ccgcatggct gccgcctggt
    19921 cagcgggcca cgagggctgc tgagcagcgg gcttcgcgag cgcctcgtcg agctgcttac
    19981 gcagtccggc aggcaacggc gggagttcgg gcaagcggtc gatcggcacg tcgacagtcc
    20041 agttcacctc tacaggatat tcgctcgctc gtcggcgcgt cacacaggct ctcgatcgca
    20101 gcccaatcgg aacacttccc gcgcaccgaa acctgggtca gcgaagtgac cgtgcagccg
    20161 aaatggcgtc gaacttcacg aggttgtgcc tggcgtcggc aagtgcgtcg tgtgcgtcgg
    20221 cgggcgccga cgggagggca ggactgccgt tgtcttccca gaactgtcgg agttcgcggg
    20281 tgtaccgcgg catcgactgc ggtagttccg tcatgtcgcc ccacaactgg cacagcgcga
    20341 cgtggtcgta ggcggcgacc cacgcccaga gctccggaac caccatcggc cgcggaacga
    20401 agaatttcag aagatcgtcg cggatcttct cgcgtgattt ccacagcggc gacgaaggct
    20461 gcggcaactt cggcagcacg ttcttgcgca cccaactacc ggcacgggcg ggatcgaact
    20521 ccgtcgaaac cgcgtagtac tctcggccgt cctcacagac aacgccgatg gacacgagat
    20581 cgatggttcg accgtcttcg atgaattcac agtcgtagaa gtagcgcacg tccgaaaact
    20641 atgccgcacg cgcaggctct ggagccaatg cgcgtgcggc cggtgtggga aatctctagc
    20701 tggcttgtgc gtccgggagc gaatccttgt cggacttcgc ggattccttc gactcggccg
    20761 aggccacgag atcgacaacc gactcgccgc cttccgccgg aacgtcgacg gcagcttcgg
    20821 gtttcgtggg cgcctggttc ttgaggcttg ccgcgtagat gtccacgtac tcctggccgg
    20881 agagtttcat caacttgtac atcacctcgt cggtcacagc gcgctcgacg aagcggtttc
    20941 cgcccatgcc ttcgaagcgg gagaaatcga tgggttcgcc gacgatcacg gtgaccttgg
    21001 cgggacgcca catccgtgag ccgatcggat tcatcttgtc ggtgccgacc atcgctaccg
    21061 ggatcacctt gacgcccgat tcaagtgcga ggcgcgccat tccggtcttg cccttgtaga
    21121 ggcgaccgtc aggcgagcgc gtcccctcgg ggtagatacc cagcaggctg cccgaaccga
    21181 ggaccttgag accggcgttg agtgcatcct gcgccgcgtc tgcaccggtt cggtcgatgg
    21241 ggacctgacc gaccgcggtg aagaaccact tctggaaagc gcccttcaga ccggaaccgg
    21301 tgaagtactc actcttggca aggaacgtga tgcggcggtt gacgcgaagc ggaaggtaga
    21361 acgagtccag aaccgcctgg tgattgctgg ccagaatggc cgccccgtca gtcggaatgt
    21421 tctcgtgacc cttgaccgtc ggacgcccga gcagccagag aatcggcccc agcaacacat
    21481 acttgaagag ccaataccac acggcgtccc tcccattcac agctgaattt cgctgagtac
    21541 gaccttactg ccgaccggta acccccgcta cacacgcccc tgcaggatcg acccgatcac
    21601 agtccggcag acgtggttcc agcgccgtcg accccaccga ggtcctgagg cactaccgat
    21661 cgggccaaag cggcggcgcc gaccatgccc gcagcttcgc ccagctgagc ggaacggatg
    21721 cgggccagtg ggcggtgctt cgccccggtc aacaatgtcg cgtactgctc gcgggcgtcg
    21781 tcgagaaaca gtggggcaga actcgcgacg ccgccggcga tcacgaccag atcgggatcg
    21841 tagacgtcac cgaccatggc cagacccacg gccagccaac gggtgaactc ggcgatcgtt
    21901 gccagcgcga gtgggtcacc gtcctgcgcg gcgttggcga tccggcgacc ggtgagcgaa
    21961 ccaggatcca ccgcaacctc acgcgccagg accgtcgacg cggccgggtc ggcggcaagc
    22021 agttcgattg ccgtgtcgac gagcgccgtt ccgctgcaat agcgctccca acacccacgt
    22081 ttgccacacg cgcactgacg cccgcccgga acgacctgga tgtggcccag ttcgggggcg
    22141 acgccgtgac tcccccggta cagctcaccg ttgatcagca gcgcaccacc gatgccggtc
    22201 ccgattgcca ccatcacgac attgcggcca cctgcggccg cgccgaatcg atgctccgcg
    22261 aaagccgccg cattggcgtc gtgttcgaga acgaccggca agccgagccg cttgctcaag
    22321 tcacttccga ccggcgcgtc cacccacggc aagtgcggag cgaaccgaac cgagcttcga
    22381 tcggaggtga tgaagccggc gaccgccaac cccacggccg atacctcgtg cctggtgacc
    22441 aattcgcgca cgacgcgatc gagaccgtct tcgagtgccc tggccgactg cggggtcggg
    22501 gcttgaatca tctcgagcac ttgtccgtcg acgtccacga cggaggccct gatactcgtc
    22561 ccgccgacgt cgatgccgac cgtcaagatg tcgtccatgg tggagtcgga gaccgctttc
    22621 aagcggcgcg cgctcatcgc gacgattccc gcgcgagcgg cgtccgctgg agtgcgcacc
    22681 ctgaatcggt gcctcgtgcg tcggtgacca ttgtgtcgat tgtgctcatc tcgggccgtt
    22741 cgctctaccc ggggtactga gtcagtcctt gaccgtcacg ttgatcggga caaatgccgc
    22801 cgtgcgagtt cgctccgcac ctggcgtcgt cggaccgccg tccggtccac gatcgggacc
    22861 tgacggcccc ccgagaaact cgtcgagaat ctcacgaagc aacgcaagga atgctgctgc
    22921 ttgacccgcg aggaatgcca acagttcgtg gtgctcaccg cgaaccagtg cggcgagggc
    22981 gcacaccggg caccagctgc agccggtgaa caccggctgc gtgtccgtgg acgccgagtc
    23041 actcgcaacg tctgccgtcg ctgctgcggc cttctgcagc accggttcca ggcgcgtcag
    23101 aacggtttcc gccagcgcgc gaaactccgc gacgaggcgc tcgtgctctt cgctcatacc
    23161 ggccacaccg cgggatccgg gctgaaccgg atgatcaggt aactgccgtc caactccgcc
    23221 ccgttcacga cacaacgacg cagcaccgac gccaaacgaa ctctgcgtcg tacgccgtct
    23281 gctcccacca gcacatcgtc ctccacccgg cccaacgaca acgacgacgg atccacgagc
    23341 ggaaggtaca tccgcatcac gtacaccgaa tcgactccgg tcccggactc caacgacacc
    23401 acgatgttgt ccgcggtacc gacggtgccc gaatccgtgc ccgctccacc ctcgaacgtg
    23461 gccgcgatct cgcccagagc ggccaaccct accggttcgg cgcaagcgcg ttcgaccgtt
    23521 gtgacggaca ttccatcggt tgatccacgc agttcgtcca cgacgagtgc ctgagccgcc
    23581 cggatcgacg cgagccactg cgccgccggt gaatcgtcga cacccttccc ggcgggcgag
    23641 ttgaactgcg ggacaaggtt gttgaccaca atcccgtcaa ctcgcaaccc ggccagagcc
    23701 agcccggaca acgtccgacg agtcgccgcg accgacacgc cgtcggccga cgtcaccaca
    23761 cgcacgccgg tgttctcccg atccgagagg tgaaccgcga tccgatccac cgacgcgagc
    23821 acgcgttcga ccacggacac gagcaggagc agccgcatgt ccgtacctgt cacagcgacc
    23881 atccgcctgt gccgcggcca caatcgctcg agatactccg acaccatcga cggcgagccg
    23941 agtatccgca gcgcttcggc tgcggccgga cagtccacga tcacgacgtc gtagtcgccg
    24001 ctgtccgaga ggtcgacgat ctcggcgagc ccgagcatgt cttggatgcc cagggatccc
    24061 gtcaactctt ccggttccaa gccctcgaac gacgaaccgt gttcgtgatc tcccgctccg
    24121 aaagttcctg cagcgtcgat caaccccgac aatcctcgga acttgtcctc gaggagcgct
    24181 gacgtgtcga gttgccggac gtcgagacgc tcggtgagag atgtggtcgt tcgcggattc
    24241 ggcacgccca ggacgtctgc aagagaacct gcctgatcga tcgacacgag cagcactctc
    24301 gccccatcgg tcgcagccga cacagcagtc gctgcggcaa gcgtcgtcgt gcctactccg
    24361 cctttaccga cgaacagttg gacgcgcgat cgttgctccg gcactcagcc ctcgactcgc
    24421 ttcttcagtt ccttcagagc tgtgtcggtg atgatcttct cggccttgcg cttgaacagt
    24481 ccgatcatcg gaatcgtcag gtcgaccgtc aactcgtagg tgaccgacgt ggtgccgttc
    24541 aggccgggct cgagtgtgta cgaaccgaat tgggacttct gaatctcgcc cgagatcagc
    24601 tcccaactca ccgccatacc gttcggtgcc cacgaatact gcagttcgta ggtgtccttc
    24661 accatccccg cgtcgaggac gaaacgtact cggtccgcgc ggccgccctg tcccggcgcc
    24721 gtcacctcga cggacttcgc cgcggccacc cactcggggt accgctcgaa atcggcgatg
    24781 acgtccatca cggcgtcggc aggagcgtcg atgctgatca accccttggt cttctcggcc
    24841 atacgactgc gctaccttcc ttcgtcaaaa gtccagaacc tgcacaacgt gcagtgcttc
    24901 gattatcagt ccggtgctac tccggcggca cgtcccgctt cgagttcgcg tttgagctgg
    24961 aacgacatga ccttgccgtc gacccgacgc ttgcggttca tcccggcgag gtcgagggtc
    25021 gccagatcgg acggcgatac gccgaccggc tcacagtgca ggaagtagtg cgcgatcgtc
    25081 ccgtccatga ccggttcgag ccagacctcc atggtgccga ccagctgacc tgacactccc
    25141 caacggaatc ctgcgggacc gcgatcttcc cggacttcga gctcgagatc actgaaccag
    25201 cgacgccact gcgcgcgcga ggacaacagt tcggcgaccc gctcgggcgg ggcggcgatg
    25261 aaagtctggt ctgcgacctg aatgctgctc accgaagtag cttcacatat cgcgtccgcg
    25321 aagcgtcgag gggtgtcgca acactacata ccggacagac tgtaag
//
