LOCUS       NZ_JAPWIK010000007     25448 bp    DNA     linear   CON 14-FEB-2024
DEFINITION  Rhodococcus qingshengii strain IEGM 766
            NODE_7_length_276774_cov_282.431474, whole genome shotgun sequence.
ACCESSION   NZ_JAPWIK010000007
VERSION     NZ_JAPWIK010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Rhodococcus qingshengii
  ORGANISM  Rhodococcus qingshengii
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Rhodococcus; Rhodococcus erythropolis group.
REFERENCE   1  (bases 1 to 276774)
  AUTHORS   Krivoruchko,A.V. and Elkin,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-DEC-2022) Lam, Institute of Ecology and Genetics of
            Microorganisms, Ural Branch of the Russian Academy of Sciences,
            Golev Str., 13, Perm, Perm Kray 614081, Russia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2022
            Assembly Method                   :: SPAdes v. 3.15.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 311x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/14/2024 02:58:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,449
            CDSs (total)                      :: 6,385
            Genes (coding)                    :: 6,320
            CDSs (with protein)               :: 6,320
            Genes (RNA)                       :: 64
            rRNAs                             :: 1, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 5 (23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 17 of 65
            Pseudo Genes (incomplete)         :: 52 of 65
            Pseudo Genes (internal stop)      :: 6 of 65
            Pseudo Genes (multiple problems)  :: 9 of 65
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:17:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 25448
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPWIK010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25448
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..25448
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25448
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:5448](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..5448)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            complement(<1..5448)
                     /locus_tag="O4271_RS22190"
                     /old_locus_tag="O4271_22185"
     CDS             complement(<1..5448)
                     /NRPS_PKS="Domain: Condensation_Starter (15-302). E-value:
                     2.3e-75. Score: 245.6. Matches aSDomain:
                     nrpspksdomains_O4271_RS22190_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (706-1101). E-value:
                     4.1e-95. Score: 310.7. Matches aSDomain:
                     nrpspksdomains_O4271_RS22190_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1210-1277). E-value: 2.9e-25.
                     Score: 80.3. Matches aSDomain:
                     nrpspksdomains_O4271_RS22190_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1299-1602). E-value:
                     1.5e-114. Score: 374.0. Matches aSDomain:
                     nrpspksdomains_O4271_RS22190_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748691.1"
                     /locus_tag="O4271_RS22190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22185"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_269613383.1"
                     /sec_met_domain="AMP-binding (E-value: 3.3e-106, bitscore:
                     349.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.8e-15, bitscore:
                     49.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1e-67, bitscore:
                     222.3, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPFEVSRTDPSDETLFPLSAAQRATWFAQQFDPEVPILIAHYVE
                     LRGELDVELLDRETRAVAYEFQSPLLKVIEIDGQPMQYVDEKAEISVGLVDLRGSPDPI
                     EDALGWMRRDCRTQLDLAVDGIVATAVLRVGDAHYLWYSRIHHVALDGFGAMTMMNRIA
                     HRYSASAARKDSQPSRAATLRTLYDIDERYRMSDRFAADREYWAERNTTLTGSSLAEAS
                     GPAQTESRLESTLMSDRSCALLYESENHAAPVIAALALYLARMTAKETVQIHVPMSGRT
                     TAVLRDSGGMMVNVTPLLIRVAAVDTVGELFAQVQHELMGALRHQRCSLDDIRRDAGVT
                     SGLEGEDSYAGPMVNVMLFRQEVQLGEVVGEYHIVTSGPVDDLLVNVYPSGDRLRVDFR
                     ANPIRYEEAGLREHHRNFVGLLEELIASDSGAELADIHSPTAREGERRRREVRHLEYWR
                     HELTGAPELLQLPFDRPRPATQSLENGRVEVLIAADTHARITAMASDLGTDTRAVLHAS
                     FALLVSRLSGASDVVIGTPTGSDANIVAIRSRIDLETPFTALLGSVVEVRSNALPHSGI
                     RLEQLVQPLHVEDVPAYAPVVQVMFESVAGADERPRDIGRFDLGVSAVELFDEVGTPSG
                     ISVRLAFATDLFDAETVRGLGLRFACVLESVTADPAIMVGDIDILSDDERSAIRPVRGD
                     PRASHRTLADLFDGAARTHPDGVALSYLDDELTYRELDERSSKLARELIDRGIGPENIV
                     ALGMTRSIESVVAMLAVSKAGAAFVPVDPTYPNERVRFMLTDSGAVLGLTVVAELHRLP
                     DSVPWSAIDDAEFRGRLARLSVRSISDVDRVRPIRPDNPAYVIYTSGSTGLPKGVTVSH
                     RGLEALAAEQRSRFGATQDARTLHFSTPSFDASIFEYLLAFGAGATMVIAPSTIYGGDE
                     LSHFLESQRVTHGFVTTAALGTVSPEGLSDFGEVVVGGEACPPDLVQRWAPGRRLCNAY
                     GPTETTVMSNIGEPMVSSEDITVGGPLRGFEEIVLDQRLHPVPDGVVGELYISGDALAR
                     GYHRKYALTAERFVADPFGLPGQRMYRTGDLVRWRRGRGLEYVGRSDFQVKVRGFRIEL
                     GEIDSVVRSCPQVENAVTVARAAPSGTATITTYVVPAGGSALSTAELTRYVASRVPSYM
                     VPAAFVLLDELPVTPAGKVDRAALPAPRLDARSDDFRPPEGAEELVLAEIFADVLGVET
                     VGAGDDFFDLGGNSLIATKLIARVNAAEEIDFRVRTLFEAPTIESLARHVRDAKSSRVD
                     RTRSKRPILQAHSYRDKIPVSVAQRRLWFVNQFDTSSPAYNIPMVVRLSGALDVAAMQR
                     AVGDVVDRHESLRTVYPASVDGPHQVVVPSERVTSKIAWEVSVDEEALDRRIADLAREG
                     FDVSANVPLRGSLFRVTPDDHVLALVVHHISADGASLEPLARDLTRAYAARAAKRAPDW
                     SPLPVQYADYSQWQIELLGSDDDPDTLEAKQLDYWTSTLAGLPDVIDLPLDRPRPAERS
                     MRGESVRFSVPADVHSELLELARNHNTTPFMVMHAVLAVLLARLSASPDIAIGTPVGGR
                     AEQVLDDLVGMFVNTVVLRITVDTAATFEEILSRTREVDLAAFGQAEVPFERVVDAVAP
                     ERSSSRSPLFQVLLEFQNTADPHLELPGLGVDVVPVDVGVAKFDLQLSLSEQRGKDGVP
                     MGFDAAFTYASDIFERTTVAEFGERFVRLLRSVVSDPTVPVGDTEILGAPERGLVVGGW
                     DGVGVVVGGLTLVDVLDGRFAGVGGGGLVCGGVVLSWGEFDVRVNRFARLLISLGVGPE
                     S"
     CDS_motif       complement(493..606)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0016"
                     /evalue="3.50E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1652"
                     /protein_start="1614"
                     /score="51.5"
                     /tool="antismash"
                     /translation="REVDLAAFGQAEVPFERVVDAVAPERSSSRSPLFQVLL"
     aSDomain        complement(643..1551)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS22190_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.50E-114"
                     /label="O4271_RS22190_Condensation_LCL.1"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1602"
                     /protein_start="1299"
                     /score="374.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHISADG"
                     /tool="antismash"
                     /translation="DKIPVSVAQRRLWFVNQFDTSSPAYNIPMVVRLSGALDVAAMQRA
                     VGDVVDRHESLRTVYPASVDGPHQVVVPSERVTSKIAWEVSVDEEALDRRIADLAREGF
                     DVSANVPLRGSLFRVTPDDHVLALVVHHISADGASLEPLARDLTRAYAARAAKRAPDWS
                     PLPVQYADYSQWQIELLGSDDDPDTLEAKQLDYWTSTLAGLPDVIDLPLDRPRPAERSM
                     RGESVRFSVPADVHSELLELARNHNTTPFMVMHAVLAVLLARLSASPDIAIGTPVGGRA
                     EQVLDDLVGMFVNTVVLRITVD"
     CDS_motif       complement(655..744)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0015"
                     /evalue="1.10E-12"
                     /label="C5_LCL_267-296"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1598"
                     /protein_start="1568"
                     /score="40.3"
                     /tool="antismash"
                     /translation="DIAIGTPVGGRAEQVLDDLVGMFVNTVVLR"
     CDS_motif       complement(1015..1050)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0014"
                     /evalue="6.40E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1478"
                     /protein_start="1466"
                     /score="12.5"
                     /tool="antismash"
                     /translation="QYADYSQWQIEL"
     CDS_motif       complement(1099..1164)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0013"
                     /evalue="7.00E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1450"
                     /protein_start="1428"
                     /score="21.9"
                     /tool="antismash"
                     /translation="VHHISADGASLEPLARDLTRAY"
     CDS_motif       complement(1369..1485)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0012"
                     /evalue="1.30E-19"
                     /label="C2_LCL_024-062"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1360"
                     /protein_start="1321"
                     /score="62.5"
                     /tool="antismash"
                     /translation="PAYNIPMVVRLSGALDVAAMQRAVGDVVDRHESLRTVYP"
     CDS_motif       complement(1507..1536)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0011"
                     /evalue="3.30E-02"
                     /label="C1_LCL_004-017"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1314"
                     /protein_start="1304"
                     /score="7.3"
                     /tool="antismash"
                     /translation="SVAQRRLWFV"
     aSDomain        complement(1618..1818)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS22190_PCP.1"
                     /evalue="2.90E-25"
                     /label="O4271_RS22190_PCP.1"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1277"
                     /protein_start="1210"
                     /score="80.3"
                     /tool="antismash"
                     /translation="LVLAEIFADVLGVETVGAGDDFFDLGGNSLIATKLIARVNAAEEI
                     DFRVRTLFEAPTIESLARHVRD"
     aSModule        complement(1618..5403)
                     /complete
                     /domains="nrpspksdomains_O4271_RS22190_Condensation_Starter
                     .1"
                     /domains="nrpspksdomains_O4271_RS22190_AMP-binding.1"
                     /domains="nrpspksdomains_O4271_RS22190_PCP.1"
                     /locus_tags="O4271_RS22190"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2119..2181)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0010"
                     /evalue="3.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1110"
                     /protein_start="1089"
                     /score="35.2"
                     /tool="antismash"
                     /translation="YVGRSDFQVKVRGFRIELGEI"
     aSDomain        complement(2146..3330)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS22190_AMP-binding.1"
                     /evalue="4.10E-95"
                     /label="O4271_RS22190_AMP-binding.1"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1101"
                     /protein_start="706"
                     /score="310.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DGAARTHPDGVALSYLDDELTYRELDERSSKLARELIDRGIGPEN
                     IVALGMTRSIESVVAMLAVSKAGAAFVPVDPTYPNERVRFMLTDSGAVLGLTVVAELHR
                     LPDSVPWSAIDDAEFRGRLARLSVRSISDVDRVRPIRPDNPAYVIYTSGSTGLPKGVTV
                     SHRGLEALAAEQRSRFGATQDARTLHFSTPSFDASIFEYLLAFGAGATMVIAPSTIYGG
                     DELSHFLESQRVTHGFVTTAALGTVSPEGLSDFGEVVVGGEACPPDLVQRWAPGRRLCN
                     AYGPTETTVMSNIGEPMVSSEDITVGGPLRGFEEIVLDQRLHPVPDGVVGELYISGDAL
                     ARGYHRKYALTAERFVADPFGLPGQRMYRTGDLVRWRRGRGLEYVGRSDFQVKVR"
     CDS_motif       complement(2266..2355)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0009"
                     /evalue="3.70E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="O4271_RS22190"
                     /protein_end="1061"
                     /protein_start="1031"
                     /score="44.8"
                     /tool="antismash"
                     /translation="PDGVVGELYISGDALARGYHRKYALTAERF"
     CDS_motif       complement(2836..2895)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0008"
                     /evalue="1.60E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="O4271_RS22190"
                     /protein_end="871"
                     /protein_start="851"
                     /score="29.7"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGLPKGVTVSH"
     CDS_motif       complement(3106..3147)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0007"
                     /evalue="3.10E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="O4271_RS22190"
                     /protein_end="781"
                     /protein_start="767"
                     /score="14.2"
                     /tool="antismash"
                     /translation="LAVSKAGAAFVPVD"
     CDS_motif       complement(3646..3741)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0006"
                     /evalue="2.50E-03"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="O4271_RS22190"
                     /protein_end="601"
                     /protein_start="569"
                     /score="10.1"
                     /tool="antismash"
                     /translation="ALPHSGIRLEQLVQPLHVEDVPAYAPVVQVMF"
     CDS_motif       complement(4381..4503)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0005"
                     /evalue="1.30E-09"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="O4271_RS22190"
                     /protein_end="356"
                     /protein_start="315"
                     /score="30.6"
                     /tool="antismash"
                     /translation="QHELMGALRHQRCSLDDIRRDAGVTSGLEGEDSYAGPMVNV"
     aSDomain        complement(4543..5403)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS22190_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="2.30E-75"
                     /label="O4271_RS22190_Condensation_Starter.1"
                     /locus_tag="O4271_RS22190"
                     /protein_end="302"
                     /protein_start="15"
                     /score="245.6"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHVALDG"
                     /tool="antismash"
                     /translation="LFPLSAAQRATWFAQQFDPEVPILIAHYVELRGELDVELLDRETR
                     AVAYEFQSPLLKVIEIDGQPMQYVDEKAEISVGLVDLRGSPDPIEDALGWMRRDCRTQL
                     DLAVDGIVATAVLRVGDAHYLWYSRIHHVALDGFGAMTMMNRIAHRYSASAARKDSQPS
                     RAATLRTLYDIDERYRMSDRFAADREYWAERNTTLTGSSLAEASGPAQTESRLESTLMS
                     DRSCALLYESENHAAPVIAALALYLARMTAKETVQIHVPMSGRTTAVLRDSGGMMVNVT
                     PLLIRV"
     CDS_motif       complement(4555..4626)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0004"
                     /evalue="2.00E-08"
                     /label="C5_starter_265-294"
                     /locus_tag="O4271_RS22190"
                     /protein_end="298"
                     /protein_start="274"
                     /score="26.7"
                     /tool="antismash"
                     /translation="VPMSGRTTAVLRDSGGMMVNVTPL"
     CDS_motif       complement(4951..5016)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0003"
                     /evalue="1.10E-09"
                     /label="C3_starter_134-155"
                     /locus_tag="O4271_RS22190"
                     /protein_end="166"
                     /protein_start="144"
                     /score="31.1"
                     /tool="antismash"
                     /translation="IHHVALDGFGAMTMMNRIAHRY"
     CDS_motif       complement(5230..5334)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0002"
                     /evalue="1.60E-08"
                     /label="C2_starter_024-063"
                     /locus_tag="O4271_RS22190"
                     /protein_end="73"
                     /protein_start="38"
                     /score="27.2"
                     /tool="antismash"
                     /translation="LIAHYVELRGELDVELLDRETRAVAYEFQSPLLKV"
     CDS_motif       complement(5359..5400)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS22190_0001"
                     /evalue="4.40E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="O4271_RS22190"
                     /protein_end="30"
                     /protein_start="16"
                     /score="10.0"
                     /tool="antismash"
                     /translation="FPLSAAQRATWFAQ"
     misc_feature    5560..5573
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.76"
                     /tool="antismash"
     gene            5709..6533
                     /locus_tag="O4271_RS22195"
                     /old_locus_tag="O4271_22190"
     CDS             5709..6533
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003941432.1"
                     /locus_tag="O4271_RS22195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22190"
                     /product="FAD binding domain-containing protein"
                     /protein_id="WP_007733027.1"
                     /transl_table=11
                     /translation="MDITTITDVIRRPPDRPGDVWRPGDAWLAGGTWLFSAEQPDTRRL
                     VDLTALGWTPLEVGPTHFGVGATCTVAELYAFVPPDNWRASPLIRVSCEYFLSSFKVWN
                     SATVGGNICMSLPAGPMITLAVALEASFTLWATDGTVRTVDACDFVTGDHQNVLEPGEV
                     LRSIEFPVHALTKRHAHRRFSLTHLGRSTIFMIATQTPGADDFHLTITAGTTHPIRLTF
                     DTMPDEHSLRRAVDSISADIWFDDPNGTPDHRLHLARHYADELRNELTGSQS"
     gene            6530..9223
                     /locus_tag="O4271_RS22200"
                     /old_locus_tag="O4271_22195"
     CDS             6530..9223
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007733025.1"
                     /locus_tag="O4271_RS22200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22195"
                     /product="molybdopterin cofactor-binding domain-containing
                     protein"
                     /protein_id="WP_118606482.1"
                     /transl_table=11
                     /translation="MSYTVNDRQFHEEPFPGQCLRTFLRHLGHHGVKKGCDGGDCGACT
                     VWLDGTPIHSCITPAFRADGRAVTTIEGLGTPEDLHPIQQQFRDAPGFQCGFCTAGMIM
                     TSAALTDAQKEDLPRALKGNLCRCTGYRSIEDAVNGVGAIEVALPGQAVGTSVGAPAAT
                     DVVTGRAEYTMDTAIDGMLHLKVLHSPHAHARITSIDTTEALAVPGVHRVYTWKDVPRK
                     LFTTAIHTDHLVDPDDTYILDNVVRFVGQRVVAVLADSVVAAEEGRRKVKVDYEILPSV
                     FDPEEAMADGAPALHGSDDPFVRDPEHNILLELHGHVGDVEAGFAEADVIHEGTYFSPR
                     VQHAHLETHGSISWMEDGRLHVRTSSQSPSIAKVKLAHLFDLRPDQLRVFCKRVGGGFG
                     GKQEVISEDLVALATLDTGRPVCLEFTREEEFTTASPRHPMKLTIKLGAKSDGTLTAFQ
                     YRNVSNTGAYGNHGGETLFAGGAAVSLYRCANKKFDAYSVYTNNVPSGALRGYGMTQPA
                     FAVESAMTELAVALNMDPLELRRRNIVRPGDSLIALEDGPDDVIFTEDGLGQCIDLIDA
                     ALKRQPVPSLGADWLIGTGTANSLHETAPPTEHISEAWLTLGEDCVYELAIGTVEFGEG
                     TSTAHVQIAANQLGTTPSRVRIIQSDTDRTGFDTGAFASAGLFVAGNAVLRASNALRDR
                     LLAFAAHHTGVSIDQCSMDDDKIVCGSTRLTLQEILEAARPPGIRFTEARKAYGSPRSV
                     VSNTHGFRIAVHRITGEIRILYSVQATDAGVIINPAQVRGQIEGGVAQGIGFALTENFH
                     VDANGAMMNPNLRNYRIPTYADIPRTEVILVESSDSVGPLRSKGMAECCINPVAPALAN
                     ALQDATGSRFRSLPLTPERIYSGLNR"
     gene            9220..10191
                     /locus_tag="O4271_RS22205"
                     /old_locus_tag="O4271_22200"
     CDS             9220..10191
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748694.1"
                     /locus_tag="O4271_RS22205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22200"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="WP_007733021.1"
                     /transl_table=11
                     /translation="MTANTSADSAATVIIGQRVRAGLEKEFEVWQKDLNRAAADYAGFL
                     GAEIAAPTPTQPDWVIVYRFDSIAHVQAWINSATRQDYLDSGRQFFDGPATQQVVSGGI
                     RPPDPLLTVVVTHRVGDDSIDEFLAWQDRLREVESAFDGFRGTELFRPVDGVQDEWTLL
                     YRFDNAAHLDTWLTSPERQQLLAEGRKFHDFELRTVDNSFGSWFAFDENGNEAPPPSET
                     KTSIAVWVGLYPTVVLLTLALSPLKLPLWLGLLIGNLLSSFIMSFFTMPYYVNRLLRRW
                     LRPPPGIPVAKTNAQGVAIVAAVTLFWVIVFYLVTTQFWSLP"
     gene            complement(10277..11515)
                     /locus_tag="O4271_RS22210"
                     /old_locus_tag="O4271_22205"
     CDS             complement(10277..11515)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019745836.1"
                     /locus_tag="O4271_RS22210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22205"
                     /product="HNH endonuclease signature motif containing
                     protein"
                     /protein_id="WP_269613390.1"
                     /transl_table=11
                     /translation="MDSRGAWQLDGEGLKGEVLDLVRVRHELQSRLVLLIVEMFSREVL
                     GGKGFRAIAQWLHGSTNLEIGECSLLVGLARLLMLEPVVADAFHRGDVDALKARQVASF
                     CQHPPKNMTLADVDKARGILLGLASQNIADCDAVRAAIRRIEKQYGKREDGVPVGEDSE
                     RNEFYASKGLYGRVTVKGDLDAVNGARLITLLSSLSAPTPEKDGVKDTRTPALRRADGF
                     CELLRRYERAGLGPVEGGVKPHITVTASAKDMTDLKALKDLLPSTEELGFAWADWVGPI
                     SIDTARMLACDCTVTRILLDENGVPLDCGKEARTATVPQRRALAVRDGGCAFPGCGTPS
                     GWCDAHHIVHWNVGGPTDLDNLVLLCGHHHRTLHHMEWRVEIGPDRKSVFYPPMSVDPF
                     QHPIGGNSPPTAA"
     misc_feature    complement(11529..11544)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 26.77"
                     /tool="antismash"
     misc_feature    11530..11543
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.15"
                     /tool="antismash"
     misc_feature    11608..11622
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.3"
                     /tool="antismash"
     gene            complement(11634..14738)
                     /locus_tag="O4271_RS22215"
                     /old_locus_tag="O4271_22210"
     CDS             complement(11634..14738)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007732224.1"
                     /locus_tag="O4271_RS22215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22210"
                     /product="multicopper oxidase domain-containing protein"
                     /protein_id="WP_168798886.1"
                     /transl_table=11
                     /translation="MTMALAACTSGESAPEVGGNYGSGGTAVDYREPVKLSSRDGVLEV
                     RLSAHQGVIPLDTASAPVSNFLLFGYEVIRGTASDGSTSASDVYPAPTLRVNPGERLII
                     HYDNDLQDLTIQDFYDPAFTPAGGDVPIYPPALTSAPLNLHTHGVHVSPDGNADNVLLN
                     IPAGQGNVYDYAIPGTMPNGLYWYHSHRHTLTAQQTYMGLAGLLEIGRPDGNLPVVTAN
                     DVPIRDMALQYNFVFDRKGKGRQLNDANWPQFVSTLTPPAGTELADGTYRPSLAPVNFS
                     DTTEGAQYFTNWYTGPLSPANHRGQNQFVPGNLQSFVGESTTVPADPSLPDNQRDVQYT
                     VNGQFQPSLKLKPGQTEIWVLANISDFAYMPVTLTETASGAHPKFAIVGQDGNPFDEVR
                     PPVDGDGTRLVIPPASRYAIAVTMPESGDLVLEMPPLEGAKPVSNPGILYTNNGTDNPP
                     AELGTVTVDPSVISYADGFFTFPTQQLIRATPDEGEGKTTPFEFGQKLDTYTSFVDTAA
                     MTPDVTRNLTVSGGFGNEKASNSDPKAFTYEFADNTFPNIPLIQPRLNSVEEWKITNLN
                     NDEHPMHIHVNDFQVTEVVDPVAGTTTGVQPWGIDNVNVPAPVTDENENALEPASVTLR
                     TKFTEYTGTFVIHCHRLNHEDNGLMATVNVIPEVSTYAVAIPGSAGVPAKVQIFDANGD
                     KLITAVTPFPSFEGTPSVAMADVNGDMVLDLVAGTGAGSAPEVVAYNAVGGVPFTDELA
                     RFAPFDVGFRGGVNVGGVDIDGNALADNIIVASGPGMESQVKIYSTDLPADKRSAPAEF
                     GSFSPYPGSSSGVTFATGMVDSHSGRASIVTAPGAGEEPLIKTFRYDLYEPTAAAQGGS
                     DEHAGHTAGPVMTSQFLAFDQGYRDGVSLSTGWVAGAEGGAKSIVAGMLGGEGSIRVFS
                     SGSRLDGAPEMYLESPDHHSTDVAFREVAAFDPFTAPESGVGVATTSTTTGADLLVSGS
                     NGTGAEVRKFTLGRADPSATTLTPTLAGTLPPYPVGGGVLPLGGR"
     misc_feature    complement(14852..14869)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    complement(14859..14873)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.38"
                     /tool="antismash"
     gene            15056..15667
                     /locus_tag="O4271_RS22220"
                     /old_locus_tag="O4271_22215"
     CDS             15056..15667
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748763.1"
                     /locus_tag="O4271_RS22220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22215"
                     /product="glyoxalase"
                     /protein_id="WP_269613392.1"
                     /transl_table=11
                     /translation="MTTAKSVILDVPDLAAAEAFYNALGVGDRIQLHESNEPTTGFRGY
                     TLSLVVSQPNIVDAFVGAALAAGATALKPVKKSLWGYGGVVQAPDGSIWKIATSSKKND
                     GPATRTIDSLVLLLGAEDVKASKQFYLDRGLEVSKSFGRKYVEFTSAANNVTLALYGRR
                     ALAKDAGVAPEGTGSHRLTVAGASETFTDPDGFAWEAACA"
     gene            complement(15702..16715)
                     /locus_tag="O4271_RS22225"
                     /old_locus_tag="O4271_22220"
     CDS             complement(15702..16715)
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019748764.1"
                     /locus_tag="O4271_RS22225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22220"
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_007732228.1"
                     /transl_table=11
                     /translation="MTHEPKTSHGHGHTHGHGPKGFRSAVREVFSPHSHDAADSVDDAL
                     ESSAIGIRAVKISLVALGVTAVAQVAIVAISGSVALLADTIHNFSDALTAVPLWIAFAL
                     GRRAATRRYTYGFGRAEDLAGLFVLAMIALSAVIAGVEAVRRLINPVEIEHLGWVAAAG
                     LIGFIGNELVALYRIRVGRQIGSAALVADGLHARTDGFTSLAVLLGAGGVALGFPLADP
                     IIGLVITVAIVAVLRTAARDVFRRLMDGVEPELVDDAEHALMHEPGVLGVRDLKMRWIG
                     HRLHADAELDIDPRATLAEAHAIAHSAEHSLTHAVPKLATALVHAYPAHDAANSEV"
     gene            complement(16712..17134)
                     /locus_tag="O4271_RS22230"
                     /old_locus_tag="O4271_22225"
     CDS             complement(16712..17134)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005238135.1"
                     /locus_tag="O4271_RS22230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22225"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_003942406.1"
                     /transl_table=11
                     /translation="MNADSGVCRRKLPDDQVDLVVEVFRMLADATRVQVLWALVDRECS
                     VNELAERVGKPAPSVSQHLAKLRMARLVRTRRDGTTVFYRLENDHVRQLVTDAVFNAEH
                     AGPGLPGHHRSEGELREIHPERSANVDRTDQEEGAS"
     gene            17244..17669
                     /locus_tag="O4271_RS22235"
                     /old_locus_tag="O4271_22230"
     CDS             17244..17669
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011593749.1"
                     /locus_tag="O4271_RS22235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22230"
                     /product="nitroreductase/quinone reductase family protein"
                     /protein_id="WP_029255500.1"
                     /transl_table=11
                     /translation="MSTDDWNAGIIAEFRENEGKVGGPFEGAPMVLVHHTGRKSGRDFV
                     SPMMYLADEQDPKTIYVFASKAGAPTNPDWYYNLVATDQAEVEIGTETYPVSVSEVTGE
                     KRDRIYDEQASRYPGFAEYAEKTAGIRTIPVVALTRA"
     gene            complement(17730..18116)
                     /locus_tag="O4271_RS22240"
                     /old_locus_tag="O4271_22235"
     CDS             complement(17730..18116)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003942402.1"
                     /locus_tag="O4271_RS22240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22235"
                     /product="DUF2784 domain-containing protein"
                     /protein_id="WP_075833371.1"
                     /transl_table=11
                     /translation="MVYRLIEVVTVFVHFGFVLYVVLGGFVAWKWRRTIGFHLLAVVWG
                     AGSIAVGYDCPLTNLENWARRMAGIAELPSTGFISHYITGVFYPASIEGLVQALAATVV
                     VGSWVGYVLLGRHSKAEVKASSVS"
     gene            complement(18190..18450)
                     /locus_tag="O4271_RS22245"
                     /old_locus_tag="O4271_22240"
     CDS             complement(18190..18450)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O4271_RS22245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O4271_22240"
                     /product="hypothetical protein"
                     /protein_id="WP_223304508.1"
                     /transl_table=11
                     /translation="MEPDRWAEYGPGAVGVGWDMGLLGLARHVELGIATPLETPEWSAS
                     DEAKAFIAGSSELWAEAAIASGDDPDAAAAAAARTTAAYTG"
     gene            complement(18513..18806)
                     /locus_tag="O4271_RS22250"
                     /old_locus_tag="O4271_22245"
     CDS             complement(18513..18806)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005247896.1"
                     /locus_tag="O4271_RS22250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22245"
                     /product="DUF1905 domain-containing protein"
                     /protein_id="WP_042449548.1"
                     /transl_table=11
                     /translation="MATDKTPQPLDYSFTAPIEKDGAFATFLTVPGSAELLGTRRAVKV
                     LGTLDGEHPFEATLMPSGDGPHWLPLRVALCKAIGKSAAGEEVAVHLQQRLS"
     gene            complement(18813..19160)
                     /gene="hisI"
                     /locus_tag="O4271_RS22255"
                     /old_locus_tag="O4271_22250"
     CDS             complement(18813..19160)
                     /EC_number="3.5.4.19"
                     /GO_function="GO:0004635 - phosphoribosyl-AMP
                     cyclohydrolase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003942390.1"
                     /locus_tag="O4271_RS22255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22250"
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="WP_003942390.1"
                     /transl_table=11
                     /translation="MSLDPAIAAKLKRNDAGLFSAVAQEKSTGDVLMVAWMDDEALART
                     LETRKGTYYSRSRQQYWVKGETSGHTQYVHEVRLDCDGDSVLLIVDQEGAACHTGTHTC
                     FDTDVLLAAEQ"
     gene            19261..19782
                     /locus_tag="O4271_RS22260"
                     /old_locus_tag="O4271_22255"
     CDS             19261..19782
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003942395.1"
                     /locus_tag="O4271_RS22260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22255"
                     /product="universal stress protein"
                     /protein_id="WP_047272212.1"
                     /transl_table=11
                     /translation="MNHQHHDGPHPEYTCHLANPSTDRVRTRHVVLGIGPGATSKNVLS
                     YALTLAAKEDSALHVVHCITSEDLPVETDSPEFETRLHDEMVSQREQTTSALASHADTW
                     TYDCTYGDPAGVILATADKYDAFTIVIGSPRKGAASAVSRLMHISVTSRLNRQNRYPVI
                     SVPTGVSSAR"
     gene            complement(19804..21285)
                     /locus_tag="O4271_RS22265"
                     /old_locus_tag="O4271_22260"
     CDS             complement(19804..21285)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003942410.1"
                     /locus_tag="O4271_RS22265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22260"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_269613401.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.4e-17, bitscore:
                     56.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQYDAVVVGAGFGGMGAAIQLKRLGLNNLAILEREDDLGGTWH
                     VNRYPGLAVDIASVTYSYSFEPNPNWSRLFAPGAELKKYADHVADKYDLRKHMTFGAVV
                     NGARWDEDSSHWVVSVEGAPDITAKYLLTATGFLSQPRRPDISGIGDFAGKIIHTTAWD
                     DSYDLSGTKTAIIGTGATAVQLIPEVARQAAELTVYQRTPIWVVPKIDVPIPNAVQKLF
                     SRIPLTQRIARAVSSSILEMIMVSAVLHYKQVKLLNKGAAAASRAFLRSQVSDASLRKQ
                     LTPDYDFGCKRPTFSNSYFRTFTKDNVHLETTPIDHIAADGIVTADGRKTEIDTLVLAT
                     GFNLWDVNFPAIEVIGREGRNLGKWWRDNRFQAYEGVAVPYFPNFLTLASPYSYSGLSY
                     FTTIESQMQHMDRLFGEVKRRGAETFEVTETANAEFLDRMTENLADSVFYGGSCQTARS
                     YYFNQHGEAAILRPTSTRNAFVEAKRFPLEDYSII"
     gene            21378..22007
                     /locus_tag="O4271_RS22270"
                     /old_locus_tag="O4271_22265"
     CDS             21378..22007
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003942392.1"
                     /locus_tag="O4271_RS22270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22265"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_037126827.1"
                     /transl_table=11
                     /translation="MTKAMTRAERKKAELRREIIDASFECFAQRGYHATGIADIATTLG
                     IGHGTFYRYFENKRDIIDHVIDDLVAKIISALATENAPDAASTLDEYRAQVGRIAEALP
                     RIFFDDPRIPRVLLFETTGVDADLTGRMLDLLDQSASLTAAYLHHGVECGYLRADLDVD
                     NTAHAVNGMMLASAIQGLRAGSSVDCTALNQAISRLMFDGIRAENA"
     gene            complement(22004..22777)
                     /gene="hisF"
                     /locus_tag="O4271_RS22275"
                     /old_locus_tag="O4271_22270"
     CDS             complement(22004..22777)
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003942380.1"
                     /locus_tag="O4271_RS22275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22270"
                     /product="imidazole glycerol phosphate synthase subunit
                     HisF"
                     /protein_id="WP_003942380.1"
                     /transl_table=11
                     /translation="MTLAVRVIPCLDVDAGRVVKGVNFENLRDAGDPVELAAAYDAQGA
                     DELTFLDVTASTSDRGTMLDVVSRTAEQVFIPLTVGGGVRTVADVDRLLRAGADKVSVN
                     TAAIARPELLKELSERFGSQCIVLSVDARTVPQGQPDTPSGWEVTTHGGKRGTGIDAVE
                     WAERGAELGVGEILLNSMDADGTKAGFDLLMIRAVRAAVHVPVIASGGAGLVEHFAPAV
                     EAGADAVLAASVFHFGDLSIPEVKDAMRAEGIVVR"
     gene            complement(22774..23607)
                     /locus_tag="O4271_RS22280"
                     /old_locus_tag="O4271_22275"
     CDS             complement(22774..23607)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003942414.1"
                     /locus_tag="O4271_RS22280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22275"
                     /product="inositol monophosphatase family protein"
                     /protein_id="WP_003942414.1"
                     /transl_table=11
                     /translation="MTPTRDLDELLAIAGRLLDGVHDQFVSGVGAPSAVRKGWGDFATE
                     VDLALEKRLTAELFEQTGIEVHGEEFGGPDVGSGLVWVLDPVDGTFNYSAGLPTAGTLL
                     ALLDDGVPVLGLTWLPLIGHTYATRAGGPLLVNGIAVPPLEPTDLASSIVGLGALNVNS
                     RGRIPGSFRLDLLAEISKVSSRIRIHGSTGVDLAFTAAGILGGAIVYGRNAWDNAAGVA
                     LVRGAGGVVTDLAGRPWTVESESVLAAAPGIHGEILDILNALGDPRASSSGGPQS"
     gene            complement(23617..24351)
                     /gene="priA"
                     /locus_tag="O4271_RS22285"
                     /old_locus_tag="O4271_22280"
     CDS             complement(23617..24351)
                     /EC_number="5.3.1.16"
                     /EC_number="5.3.1.24"
                     /GO_function="GO:0003949 - 1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="priA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005247511.1"
                     /locus_tag="O4271_RS22285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22280"
                     /product="bifunctional 1-(5-phosphoribosyl)-5-((5-
                     phosphoribosylamino)methylideneamino)imidazole-4-
                     carboxamide isomerase/phosphoribosylanthranilate isomerase
                     PriA"
                     /protein_id="WP_269613405.1"
                     /transl_table=11
                     /translation="MSLVLLPAVDVVNGEAVRLVQGEAGSETGYGSPRDAALAWQNDGA
                     EWVHLVDLDAAFGRGSNSELLAGVIGDLTVKVELSGGIRDDASLEAALATGCARVNLGT
                     AAIEDPEWCARALAKYGDKIAVGLDVRLVDGQYRTRGRGWVTDGGDLWETLARLDGDGC
                     TRYVVTDVSKDGTLTGPNLELLSQVCAVTDAHVVASGGVSTIEDLLAISSLVDQGVEGA
                     IVGKALYAGRFTLPEALAAVSG"
     gene            complement(24371..24622)
                     /locus_tag="O4271_RS22290"
                     /old_locus_tag="O4271_22285"
     CDS             complement(24371..24622)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007732246.1"
                     /locus_tag="O4271_RS22290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22285"
                     /product="hypothetical protein"
                     /protein_id="WP_042449550.1"
                     /transl_table=11
                     /translation="MTGGSGPNRGDDFSLARLALFSLGAAVAALAVATVVIVVLKPSPG
                     VGLVIGLVGVVAAIAAMGVVSKRMTRKAFGDPEDGSRS"
     gene            complement(24619..25254)
                     /gene="hisH"
                     /locus_tag="O4271_RS22295"
                     /old_locus_tag="O4271_22290"
     CDS             complement(24619..25254)
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005247515.1"
                     /locus_tag="O4271_RS22295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_22290"
                     /product="imidazole glycerol phosphate synthase subunit
                     HisH"
                     /protein_id="WP_003942389.1"
                     /transl_table=11
                     /translation="MSASTIAVLDYGSGNLHSATRALARTGAQVEVTNDMKVALAADGL
                     VVPGVGAFAACMEGLRAVQGDRIIGRRLAGGRPVLGICVGMQILFDRGVEFGVEAEGCG
                     EWPGTVERLQAEVLPHMGWNTVEAPESSTLFKGIDADTRFYFVHSYGVQSWELAPSEHI
                     APPKLTWADHGGKFLAAVENGALSATQFHPEKSGDAGAELLSNWVQSL"
ORIGIN
        1 cgactccgga cccaccccca acgaaatcaa caaccgcgca aaacgattca cccgaacatc
       61 gaactcaccc cacgacaaca ccaccccacc acacaccaac cccccaccac ccacaccagc
      121 aaaccgccca tccaacacat ccaccaacgt caaacccccc accacaaccc ccacaccatc
      181 ccaaccaccc accaccaacc cacgctcggg cgcgcccaaa atttccgtat cccctactgg
      241 cactgttgga tccgacacga ccgaccggag gaggcggacg aaacgctcgc cgaactcggc
      301 gactgtggtg cgctcgaaga tatcggaggc ataggtgaag gcggcatcga aacccatggg
      361 gacgccgtct ttgccacgct gctcggagag cgacagttgc aagtcgaatt tggcgacacc
      421 gacgtcgact ggaacaacat cgacacccag tccgggtagt tcgaggtggg gatctgcggt
      481 gttctggaat tccaacagaa cctggaagag cggtgagcga gatgacgaac gctccggcgc
      541 aactgcatcg acgactcgct cgaacggcac ctcggcttgt ccgaacgctg ccagatcgac
      601 ttcgcgagtt cgtgaaagga tctcctcgaa agtcgcggcg gtgtcaacgg tgattcgcag
      661 gacgaccgtg ttgacgaaca tcccgaccag atcgtcgagg acttgctcgg cgcgccctcc
      721 taccggagtc ccgatcgcta tgtccggcga ggcgctcagc cgtgccaaca gaaccgccag
      781 cactgcgtgc atcaccatga acggtgtcgt gttgtgattc cgagcgagtt cgaggagttc
      841 actgtgcacg tctgcgggca ccgagaatcg gaccgattca ccgcgcatgg atcgttccgc
      901 cggtctcggt cgatccagcg gaaggtcgat cacgtcaggt agaccggcca gggtggacgt
      961 ccagtagtcc aactgcttcg cctcgagcgt gtccggatcg tcgtcactgc cgagcagttc
     1021 gatctgccat tggctgtagt cggcgtactg cacaggcaaa ggcgaccagt ccggtgcccg
     1081 tttcgcagcc cgcgccgcgt aggcgcgggt caggtcgcgg gccagcggct cgagggatgc
     1141 tccgtccgcc gaaatatggt gaaccaccag cgcaaggaca tgatcgtccg gcgtgacccg
     1201 aaaaagggag ccgcgcaggg gcacgttcgc gctcacgtcg aacccctcgc gagcgagatc
     1261 ggcgatgcgc ctgtccaagg cttcctcgtc cacggatact tcccacgcga tcttcgacgt
     1321 cacgcgttcc gaaggcacta ctacctgatg ggggccgtcg accgacgccg ggtagacggt
     1381 acggagcgat tcatgccgat cgacaacatc tcccaccgcg cgctgcatcg cagcgacatc
     1441 caaggcacct gacagtcgga ccaccatcgg aatgttgtag gccggggacg acgtgtcgaa
     1501 ctgattgacg aaccacaggc gtcgttgtgc cacagacacc ggaatcttgt ccctgtacga
     1561 atgtgcctgc aggattggac gcttcgaacg cgtgcgatca acgcgggatg acttcgcatc
     1621 ccgcacgtga cgggccaatg attcgatagt cggtgcttcg aacaaagtcc gcaccctgaa
     1681 atcgatttct tcagcggcat ttacgcgagc gatcagcttc gtggcaatca gtgagttccc
     1741 gcccagatcg aagaagtcgt cacccgcacc caccgtctcg acgcctagaa catcggcaaa
     1801 aatctcggcg agcactagtt cctcagcgcc ctcgggcggt cgaaagtcgt ccgaccgagc
     1861 atcgagccga ggtgcaggta aggcagcgcg atcgaccttt cccgccggag ttaccggcaa
     1921 ctcgtcgagt agaacaaatg ccgcaggaac catgtacgac ggaacacggc tcgcgacgta
     1981 ccgcgtcagc tcggccgtcg agagcgcact tccgccggca ggcacgacgt acgtggtgat
     2041 cgtcgctgtc ccggagggag ccgcacgcgc cacggtgact gcattctcga cctgcggaca
     2101 cgaccgcacg acgctgtcga tttccccgag ttcgatacga aatccgcgaa ctttcacctg
     2161 gaagtcacta cgaccgacgt actcgagtcc acggccacgg cgccaccgca ccaaatcccc
     2221 cgttcgatac atccgctgcc cggggaggcc gaaggggtct gccacgaatc gttctgcggt
     2281 caacgcatac ttccggtgat atccacgtgc gagcgcgtct cccgagatgt acagctcgcc
     2341 cacaacaccg tcggggacgg ggtgcaatcg ctgatcgagc acgatctcct cgaagccgcg
     2401 gagcggaccg cccactgtga tgtcctccga cgacaccatc ggctcgccga tgttcgacat
     2461 gacggtggtc tcggtcggcc cgtacgcatt gcacagccgt cggccgggag cccaccgctg
     2521 cacgagatcc ggcggacagg cctcaccacc gaccaccact tcgccgaagt ccgaaaggcc
     2581 ctcgggcgaa actgttccga gcgccgcagt agtgacaaaa ccatgcgtga cacgctggga
     2641 ttcgaggaag tgagacaact cgtcaccgcc gtagatcgtg ctcggcgcaa tcaccatggt
     2701 cgctccggca ccgaaagcca gcaggtactc gaaaatcgag gcgtcgaaac tcggggtcga
     2761 gaagtgcaac gttcgcgcat cctgggtcgc accgaaccgc gaacgctgtt cggcagcaag
     2821 cgcttccagt ccacgatgcg agaccgtcac ccccttgggg agtccggtgg acccggacgt
     2881 gtagatcacg tatgcgggat tgtcgggccg gatcgggcgc acccgatcga catcggagat
     2941 ggaacgcacg gacaaccgtg caagtcggcc acggaactca gcgtcgtcga tcgctgacca
     3001 gggaaccgaa tccggcaagc gatgaagttc cgcgacgacc gtgagtccca gtacggcgcc
     3061 ggaatcggtc agcatgaagc gaacacgttc attcggatag gtcggatcca ccggcacgaa
     3121 tgccgcgccg gctttgctca cggccaacat cgcgacaacc gattcgatcg aacgcgtcat
     3181 acccagcgcc acaatgtttt ccggaccgat gccgcggtcg atcaattctc gggccaactt
     3241 cgacgaacgc tcgtcgagtt ctcgatacgt caactcgtca tcgagatacg acagggccac
     3301 gccgtcgggg tgtgtgcgcg ccgcaccgtc gaacaaatcg gccagggtgc gatgcgaagc
     3361 gcgcgggtca ccgcggacag gccgtatcgc ggatcgctcg tcgtcggaca agatatcgat
     3421 gtcgccgacc atgattgccg gatccgctgt gacggattcc aggacgcagg cgaaccgcaa
     3481 accgaggccg cgtaccgtct cggcgtcgaa tagatcggtg gcaaacgcga gcctcaccga
     3541 gattccggac ggcgtaccca cctcgtcgaa cagttcgact gcagacactc cgagatcgaa
     3601 gcggccgatg tcgcgagggc gctcgtcagc gccggcgacg gactcgaaca tcacctgtac
     3661 aaccggcgca taggcgggta catcctccac gtgcaatggc tgaaccaact gctcgagccg
     3721 tatcccactg tgcggcagcg cattacttcg gacctcgacg acactgccca agagtgccgt
     3781 gaacggcgtc tccagatcga tgcgactccg gatggcaacg atgttcgcgt cggatcccgt
     3841 cggcgtaccg atcacaacat ccgaagcacc ggacaaccgg ctcaccagga gagcaaagct
     3901 tgcatgtaag accgcacgag tgtccgtccc gagatcactc gccatcgccg tgatccgcgc
     3961 gtgggtgtcg gcggcgatca ggacctcaac ccgtccgttc tccagcgatt gcgttgcagg
     4021 tctgggccga tcgaacggaa gttgcaatag ttcgggcgcc ccggtgagct catgtctcca
     4081 atactcgagg tgccgcactt cgcgtcgtcg tcgctcgccc tcccgggccg tcgggctgtg
     4141 aatgtctgcg agttcggcac cggaatcaga cgcgatcaac tcttccagca agccgacaaa
     4201 attccggtgg tgctcgcgta aacccgcctc ctcgtatcgg atcgggtttg cccggaagtc
     4261 gacacgcagc ctgtcgccgc tcggatacac gttgaccaga aggtcgtcca ccggcccgga
     4321 ggtgacgatg tgatactccc caaccacctc gcccaactgc acctcctggc gaaacagcat
     4381 gacgttgacc atgggcccgg catatgagtc ttcgccttcc agaccgctcg tcacgcctgc
     4441 gtcccgacgg atgtcgtcga ggctgcagcg ctggtgccgc aatgcaccca tgagctcatg
     4501 ctggacctgg gcgaagagtt caccgacggt gtcgaccgct gcgacacgga tgagcagtgg
     4561 cgtgacgttc accatcatgc cgcccgaatc ccgcagcacc gccgtagtcc gtccggacat
     4621 cggaacatga atctggacag tctctttcgc cgtcatccgc gcgaggtaca acgcgagcgc
     4681 agcgatgacc ggtgcagcgt ggttctcgga ttcgtagaga agggcacaac ttcggtccga
     4741 catcagtgtg ctttcgagtc ggctctcggt ttgcgcgggc ccagaagcct ccgccaggct
     4801 ggatccggtg agggtggtat tgcgctcagc ccagtactcc cggtcggcgg cgaatcgatc
     4861 cgacattctg taccgctcgt cgatgtcgta cagcgtgcgc agcgtcgcgg cacgactcgg
     4921 ctgcgagtcc tttctcgccg ccgaggccga gtaccgatgc gcaatgcggt tcatcatggt
     4981 catggcaccg aaaccgtcga gcgcaacatg atggatgcgg ctgtaccaca gatagtgcgc
     5041 gtcacccacg cgcagcacag cggtcgcgac gattccgtcg actgccaggt cgagctgtgt
     5101 ccggcaatct cggcgcatcc acccgagggc atcctcgatc ggatcggggg acccacggag
     5161 gtcgaccaaa ccgaccgaga tttcggcctt ctcatccacg tactgcatcg gttgaccgtc
     5221 gatctcgatc actttgagca aaggagattg aaactcgtat gccaccgctc gcgtttcgcg
     5281 atccagcagt tcgacgtcga gttcgccgcg cagctccacg tagtgcgcta tcagaatcgg
     5341 gacttcggga tcgaattgct gagcgaacca ggttgcccgt tgggcggccg agagcggaaa
     5401 gagcgtctca tcagaagggt cggtccgact tacctcgaag ggtttcacag cgccccgccc
     5461 cgcatgatct ccgcggccgc cgagtgcgta gccgcgtccg aatcaacagc gcgaaagcaa
     5521 gaggctgatc gcgcctctca agcagtcgta cccagaatcg gcaagcgcat gcaccgcccc
     5581 accagtcgat gtcacgtacg tatcgctcat gtttcgcctg cccgatatgt actaaaagtg
     5641 tgaatgcgtc tcgtcacctc ggtaatgtcc cactccgaga agacacatcc cccgagggga
     5701 gcaggcgcat ggacatcacc accattaccg acgtgatacg ccgaccaccg gatcgcccag
     5761 gggacgtgtg gcgtcccggc gacgcctggc tcgcgggagg aacgtggctg ttctcagcag
     5821 aacaacccga cacgcgtcga ctggtcgacc tcaccgcgct cggttggaca ccactggagg
     5881 tcggcccgac tcatttcggt gtcggagcta cgtgcaccgt tgccgaactg tatgcgtttg
     5941 tcccgccgga caattggcgt gcgagtccac ttattcgcgt cagctgcgag tacttcctct
     6001 cgtctttcaa ggtgtggaat tcggccaccg taggcggcaa catctgtatg tcgcttccgg
     6061 ccggaccgat gatcaccctg gcagttgcac tcgaggcttc gttcacacta tgggctaccg
     6121 acggaacagt gaggaccgtc gacgcgtgcg acttcgtgac cggtgaccac cagaatgtcc
     6181 tggagccggg cgaagtcctt cggagcatcg agttcccggt gcacgcactc accaaacggc
     6241 acgcccaccg ccgcttcagt ctcacgcacc tcggccgttc gacgatcttc atgatcgcga
     6301 cgcagactcc tggcgccgac gactttcacc tcaccatcac cgccggcacc acccatccga
     6361 tccggctgac gttcgacacc atgccggacg agcactctct gcgacgagcc gtcgactcca
     6421 tttcggccga catttggttc gacgatccca acggaacccc agaccaccgc ctccacctcg
     6481 cccgccacta cgccgacgag ctccgaaacg aactcacggg gagccagtca tgagctacac
     6541 ggtgaacgac cggcagttcc acgaggagcc gttcccggga cagtgtctcc ggacgtttct
     6601 tcggcacctc ggacaccacg gggtgaagaa ggggtgcgac ggcggggact gcggggcgtg
     6661 cacagtgtgg ctcgacggaa caccgataca cagctgcatc acgcccgcct ttcgcgccga
     6721 cggtcgcgcg gtaaccacga tcgagggact cggcacgccc gaagatctcc atccgattca
     6781 gcagcagttc cgggatgcac ccggctttca gtgtgggttc tgcaccgccg ggatgatcat
     6841 gacctcggcg gcgctcaccg acgcgcagaa agaagacttg ccgcgagcgc tcaagggaaa
     6901 cctgtgccgc tgcaccggtt accgatccat cgaagacgcg gtcaacggtg tcggtgctat
     6961 cgaagttgcc ctcccgggac aggccgtcgg aaccagcgtc ggggcgccgg cggccaccga
     7021 cgtggtgacc ggccgagccg aatacactat ggacaccgcg atcgacggca tgctgcacct
     7081 gaaagtgctg cactcgcctc acgcacatgc ccgcatcacc tccatcgaca ccaccgaggc
     7141 gctcgccgtc cccggtgtcc atcgcgtcta cacctggaaa gacgtgccgc gcaagctctt
     7201 caccacggca atacataccg accaccttgt cgatccggac gacacctaca ttctcgacaa
     7261 cgtcgtgcgg ttcgtgggtc agcgtgtagt ggccgtcctc gccgactccg tcgtcgctgc
     7321 ggaagaaggc cgtcggaagg tgaaggtcga ttacgagatc ctgccttccg tgttcgatcc
     7381 ggaagaggcc atggccgacg gcgctccagc cctgcacgga tccgacgatc cctttgttcg
     7441 agatcccgag cacaacatcc tgctcgaact tcacggtcat gtgggcgacg tcgaggcagg
     7501 gttcgccgag gccgacgtca tccacgaagg cacctacttc tcgccgcggg ttcagcacgc
     7561 gcacctcgag acgcacggtt cgatctcctg gatggaagac ggacgccttc acgttcgcac
     7621 aagttcgcag tccccctcca tcgccaaggt caaactcgcc catctcttcg acctccgccc
     7681 ggatcagcta cgcgtgttct gcaaacgcgt gggcggcggg ttcggaggaa aacaggaagt
     7741 gatcagcgag gatctggtgg cgctcgccac cctcgacacc ggtcgtcccg tctgcctcga
     7801 gttcacccga gaagaagagt tcaccaccgc gtcgccgcgt catccgatga agctcacgat
     7861 caagctcggt gccaagtcgg acggaaccct cacagccttt cagtatcgca acgtatcgaa
     7921 caccggtgcg tacggaaacc acggtggaga gacactcttt gccggcggcg cggcagtatc
     7981 gctctaccgc tgcgccaaca agaagttcga tgcgtattcc gtgtacacca ataacgtccc
     8041 gagcggcgct ctgcgtgggt acgggatgac gcaaccggcc tttgccgtgg aatcggccat
     8101 gaccgaattg gccgtcgcgc tgaacatgga tccgctcgaa ctgcgtcgac gcaatatcgt
     8161 ccgaccgggc gattcgctga tcgcactcga agacggccca gacgacgtga tcttcaccga
     8221 agacggactg gggcaatgca tagatctgat cgacgccgcg ttgaagcgcc aaccggttcc
     8281 ctcgctcgga gcggattggc tgatcggcac cggcactgcc aattcgctac acgagaccgc
     8341 gccacccacc gagcacattt ccgaggcttg gctcaccctc ggcgaagact gtgtatacga
     8401 acttgccatc ggcacagtcg aattcggtga gggaacttct accgcccacg tgcagatcgc
     8461 cgcgaatcag ctgggcacaa caccgtcacg tgtacgaatc attcagtcgg acaccgaccg
     8521 aaccggtttc gacacaggcg ctttcgccag cgccggcctg tttgtcgctg ggaacgcggt
     8581 acttcgcgcg tcgaatgcgc tccgcgatcg cctacttgcc ttcgccgcgc accacaccgg
     8641 cgtgtcgatt gaccagtgct cgatggacga cgacaagatc gtctgcggta gtactcgatt
     8701 aacactgcaa gagatactcg aggccgcacg cccgcccggg atccgattca ccgaggcgcg
     8761 gaaggcatac ggatctccgc gcagcgtggt gtccaacact catggcttcc ggattgccgt
     8821 ccatcgcatc accggcgaga tccgcattct ctacagcgtc caagccaccg acgctggggt
     8881 gatcatcaat ccggcgcagg tgcggggaca gatcgaaggt ggcgtcgccc agggcatcgg
     8941 cttcgcactc accgagaact tccacgtaga cgcaaacggc gcgatgatga acccgaatct
     9001 acgtaactac cggatcccga catatgcaga tatcccacgc acggaggtga tcctcgtcga
     9061 gtcatcagac tccgtcggcc cactccgctc caagggcatg gcggagtgct gcatcaatcc
     9121 ggttgcccct gcattggcga acgcactgca ggatgcaacc gggtcacgat tccggtcact
     9181 accgctcacc ccggaacgca tctactcagg cctgaaccga tgaccgcgaa cacgtcggcg
     9241 gacagcgccg cgacggtcat catcggccag cgagtgcgtg ccggactgga gaaagaattc
     9301 gaggtctggc agaaagatct caaccgagcc gccgcagatt atgcaggctt cctcggggca
     9361 gaaatcgctg ctccgacgcc cacccaacct gactgggtga tcgtgtaccg cttcgactcc
     9421 atcgctcatg ttcaagcgtg gatcaacagc gcgacgaggc aggactacct cgacagcggt
     9481 cgtcagttct tcgacggccc ggccacgcag caggtagtga gcggcgggat caggcctccg
     9541 gacccactgc tgaccgtcgt agtgacgcac cgagtaggtg acgacagcat cgacgagttc
     9601 cttgcctggc aggatcgcct tcgggaggtg gagagtgctt tcgacggatt ccgcggcacc
     9661 gaactgtttc gccccgtcga cggtgtgcag gatgaatgga ccctgctgta tcgcttcgac
     9721 aatgctgccc acctcgatac gtggctgact tcccctgagc gacaacaact cctcgccgag
     9781 ggccgcaagt ttcacgactt cgaactgcga accgtggaca attcgttcgg cagttggttt
     9841 gccttcgacg agaacggaaa cgaggcccct ccaccttcgg agacaaaaac ctcgatcgcg
     9901 gtctgggtcg gtctctaccc gactgtcgtc ttgcttactt tggcgctgtc accgctgaag
     9961 ctgccactct ggctcggatt gttgatcggc aatctgctgt cgagcttcat catgagtttc
    10021 ttcacgatgc cgtactacgt gaatcgactc ctgcgccgtt ggctgcgtcc gcctccgggg
    10081 attcctgtcg caaaaaccaa cgcacaaggg gtggcaatcg tcgccgctgt gaccttgttc
    10141 tgggttatcg tcttctacct cgtgactact cagttctggt cgctgccctg aactctccgg
    10201 aacacgaaaa gccagcgcat gtaacggggc atgattcttc cccggtgcat acgctggcat
    10261 tttcagttat gtccgttcac gcggccgttg gtgggctgtt cccgccgatc ggatgctgga
    10321 acggatcaac cgacatcggt ggatagaaca ccgatttccg atccggaccg atctccaccc
    10381 gccactccat gtgatgcagc gtccgatgat gatgaccaca caacaagacc agattatcga
    10441 gatccgttgg gccaccaacg ttccagtgaa caatatgatg agcatcgcac caccccgacg
    10501 gagtcccgca ccccggaaac gcacacccac catcacgaac cgccaacgcc cgccgctgcg
    10561 gaaccgtcgc cgttctcgct tccttaccgc agtcgagcgg aacaccattc tcatccaaca
    10621 aaatccgcgt gaccgtgcag tcgcacgcca acatccgcgc ggtatcgata ctgatcggac
    10681 ccacccaatc cgcccacgcg aaacccaact cctcagtgga cggcaagagg tctttcaacg
    10741 ccttgaggtc cgtcatgtct tttgcgctgg cggtgaccgt gatgtgcggt ttcaccccgc
    10801 cctcgaccgg acccaacccc gcccgctcgt accggcgcaa caactcgcaa aacccatccg
    10861 cccgccgcag cgccggagta cgcgtgtcct tgacgccgtc cttctccggc gtcggcgcag
    10921 acagactcga caacaacgtg atcagacggg ccccgttcac cgcatccagg tcgcccttca
    10981 cggtcacacg cccgtacaaa cctttcgagg cgtagaactc gttacgctcc gaatcctcac
    11041 ccaccggaac gccgtcctca cgcttgccgt actgcttctc gatccgccgg atcgccgccc
    11101 gcaccgcatc acaatcggca atgttctgcg acgccaaccc caacagaatc ccgcgagcct
    11161 tgtccacatc cgccagggtc atgttcttcg gtggatgctg acaaaacgac gccacctgcc
    11221 gcgccttcaa cgcatccacg tcaccgcgat gaaacgcatc cgcgacaaca ggttcgagca
    11281 tcaacaaccg cgccaacccg accagcagac tgcactcacc gatctccaga ttcgtcgaac
    11341 catgcaacca ctgcgcgatc gcccgaaaac ccttcccacc gagaacctca cgggaaaaca
    11401 tctccacgat cagcaacacc aaccgcgact gcaactcgtg ccggacacgc accagatcca
    11461 gaacctcccc cttgaggccc tcgccatcca gctgccacgc tccccgactg tccatgctca
    11521 aagtttaatc gaacacactt tcgataacca gagacaaaac ggacaggttt caagaaacat
    11581 cgatctcgag accggttgat atgtaactac tttcagaaac tctcaaaacc tgatcatcga
    11641 ccaccgagcg gcagaactcc cccgccgacg ggatagggcg gcagcgttcc cgcaagtgtc
    11701 ggtgtcaatg tggtcgcaga cggatcggca cgaccgagag tgaatttccg aacttcggca
    11761 cccgttccgt tgctgccgct gacgaggaga tccgcgccgg tagtcgtgct cgtcgtggcc
    11821 actcccacac ccgactctgg agcggtgaac gggtcgaaag ctgcaacctc ccgaaatgcc
    11881 acgtccgtcg aatggtgatc tggactctcg aggtacatct cgggtgcacc gtcgagcctg
    11941 gatccactcg aaaagacgcg gattgatcct tctcctccga gcatgcctgc cactatcgac
    12001 tttgcgccgc cctcggcgcc ggccacccaa cccgtcgaca gagacacccc gtcgcggtag
    12061 ccctgatcga atgccaagaa ctgcgacgtc attacaggac cagccgtatg acctgcgtgt
    12121 tcatcggagc cgccctgcgc agccgccgtc ggttcgtaca ggtcgtagcg gaacgtcttg
    12181 atcaacggct cctcgcccgc gccgggtgct gtcacgatgc tcgctcgacc ggagtgactg
    12241 tcaaccattc cggttgcgaa cgtgactccg ctactcgatc ccgggtacgg cgagaacgaa
    12301 ccgaattctg cgggtgcgga cctcttgtcc gccggaaggt cggtggagta gatcttgacc
    12361 tgcgactcca tccccgggcc tgatgcaacg atgatgttgt ctgccagtgc atttccgtcg
    12421 atgtcgacac cgccgacgtt cactccaccg cggaaaccca catcgaaggg ggcgaatctt
    12481 gccaactcgt cggtgaacgg cacgccgccg actgcgttgt acgccaccac ttccggagcc
    12541 gagcctgcac ctgttccagc gaccagatca agcaccatgt ctccgttcac gtccgccatc
    12601 gcaacactcg gggtgccttc gaacgacggg aagggcgtca cagcagtgat cagtttgtcg
    12661 ccgttggcat cgaatatctg caccttggcg ggcacgccgg ccgaaccagg tatcgcgacg
    12721 gcatatgtcg atacctcggg aatcacgttg acagtcgcca tcaaaccgtt gtcctcgtga
    12781 ttgagtcggt ggcagtgaat cacaaaggtt ccggtgtact cggtgaactt cgtccgcaac
    12841 gtcaccgatg ctggttccag cgcattctcg ttctcgtccg tcaccggcgc cggcacgttc
    12901 acgttgtcga ttccccaggg ctgaacgccc gtcgtggtac ctgcgacggg atccacaact
    12961 tccgttacct ggaagtcgtt gacgtgaata tgcatcgggt gttcgtcgtt gttgaggttc
    13021 gtgatcttcc attcctcaac ggaattcagt cgcggttgaa tcagcggaat gttggggaac
    13081 gtgttgtcgg cgaattcgta ggtgaaggcc ttcggatcgc tgttgctggc cttctcgttt
    13141 ccgaacccac cggacactgt gagattgcgg gtcacgtcgg gcgtcatcgc tgcggtatcc
    13201 acgaacgagg tgtaggtatc gagcttctgt ccgaactcga agggagtcgt ctttccttca
    13261 ccctcgtctg gcgtcgcacg gatcaactgc tgagtcggga acgtgaagaa tccgtccgcg
    13321 taactgatca ccgacgggtc gacggtgacg gttccgagtt cggcgggcgg attgtcggta
    13381 ccgttgttgg tgtagagaat gcctggattg ctcaccggct ttgcaccttc gagcggtggc
    13441 atctccagca ccagatcgcc ggactccggc atcgtcactg cgattgcgta tcgcgaggcc
    13501 ggcggaatca ccagcctggt tccgtcccca tccacgggtg gcctgacctc gtcgaacggg
    13561 tttccgtcct gccctacgat ggcgaacttc ggatgggcgc cgcttgcggt ttccgtcaac
    13621 gtgaccggca tgtaggcaaa gtcgctgatg ttggcaagca cccagatctc ggtctgcccc
    13681 ggcttcagtt tcagcgacgg ctggaactga ccgttcacgg tgtactgcac atcgcgttgg
    13741 ttgtccggca gtgagggatc ggccggtaca gtcgtcgatt cacccacaaa gctctgcaga
    13801 ttgcctggaa cgaattgatt ctgtccacga tgattggccg gggacaacgg tccggtatac
    13861 cagttggtga aatactgcgc gccctcggtg gtgtccgaga aattcaccgg agcaaggctc
    13921 ggacggtacg tcccgtcggc tagttccgta ccggcgggtg gcgtcaacgt actgacgaat
    13981 tggggccagt tcgcgtcgtt gagctgtcgg ccctttcctt tgcggtcgaa tacgaagttg
    14041 tactgcagtg ccatatcgcg aatcggaacg tcgtttgccg tcacgacagg cagattgccg
    14101 tccggccggc cgatttccag tagcccggcc aggcccatgt acgtctgctg ggcggtgagg
    14161 gtgtgccggt gactgtgata ccagtacaga ccgttcggca tcgtccccgg aatcgcgtag
    14221 tcgtacacgt ttccctggcc ggcgggaatg ttgagcaaca cgttgtccgc attgccgtcc
    14281 ggactcacgt gcactccgtg cgtgtgcaga ttcagcggag ccgacgtcag cgccggcgga
    14341 tagatcggca cgtccccgcc cgccggtgtg aatgccggat cgtagaagtc ctggatcgtg
    14401 agatcctgca aatcgttgtc gtaatgaatg atcaatcgct ctccgggatt gacgcggaga
    14461 gtcggcgccg gatagacgtc actcgccgag gtcgatccgt ccgacgccgt accgcggatg
    14521 acctcgtacc cgaagagcag aaaattcgac acgggcgccg aagcggtatc gagcggaatc
    14581 actccctgat gagcggacaa gcgcacctcg agaacaccat ctcggctact cagtttcacc
    14641 ggctcccgat agtcgacggc ggttccgcca gagccgtaat tgccgcccac ctcgggcgcc
    14701 gattcaccgg aggtacacgc ggccaacgcc atcgtcatgg acaccactac tgctgcggct
    14761 aacgactttc ctcgcagtgc gatcactggt ttccccgttc catggtggcg tgaggtacgt
    14821 ccgatcagcg ctcaccagcc tatcgagaaa acatcggctg aacaggatat tcacgacaaa
    14881 tcgcccacct aaggcctgcg tgagtgctgc accttgcaag cagtctcagc aaaccgatca
    14941 gaaatcgaga agcacagcca cgggacccgc aattacgttg aaacacatga acacaccaca
    15001 gaagtccact tccgaccaca cgtcgccaat ccacacatca gcagggagcg cccagatgac
    15061 caccgcgaaa tccgtgatac tcgacgttcc cgacctcgcg gcagccgaag ccttctacaa
    15121 cgctctcggc gtcggagatc gaatccagct acacgaatcg aacgaaccga caacagggtt
    15181 tcgtgggtac accctttcgc tcgtcgtctc ccaaccgaac atcgtcgacg ccttcgtcgg
    15241 cgcagcactc gcagccggtg ccaccgcctt gaagcctgtc aagaaatccc tctggggata
    15301 cggcggagtc gtccaggctc cagacggttc gatctggaag atcgccacgt cgtcgaagaa
    15361 gaacgacggg ccggccaccc gcacgatcga cagcctcgtg ctgctgctcg gcgccgaaga
    15421 cgtcaaggcc agcaagcagt tctacctcga ccgcggactc gaggtgtcca agagcttcgg
    15481 tcgcaagtac gtcgaattca ccagtgcagc aaacaatgtg acactcgcac tgtatggtcg
    15541 ccgcgctttg gcaaaggatg ccggggttgc tccggaaggc accggatcac accgtctgac
    15601 cgttgccggc gcgtctgaaa ccttcacaga cccagacggt ttcgcctggg aagccgcctg
    15661 cgcttgacat caagcacaga tcaccgggaa ggcggccggt atcagacttc ggagttggcc
    15721 gcgtcatgcg ccgggtacgc atgcaccaag gcagtagcga gtttgggcac cgcgtgagtg
    15781 agcgaatgct cggcgctgtg tgcaatcgca tgagcttcgg caagtgttgc ccggggatcg
    15841 atgtcgagtt ctgcatcggc atgcagtcgg tgtccgatcc accgcatctt cagatcacga
    15901 acaccgagga ctccaggttc gtgcatcaat gcatgctctg cgtcgtccac caactcaggt
    15961 tcgacgccgt ccatcaacct ccggaagacg tctcgcgctg cagtcctgag caccgccacg
    16021 atggcaacgg tgatgacaag gccgatgatc ggatctgcca acgggaaacc cagcgcaact
    16081 ccccccgccc ccagaaggac tgcgagcgaa gtgaatccgt cggtccgagc atgcaatcca
    16141 tcggccacca gggccgctga accgatttgc ctgccgaccc tgatccgata caacgccacc
    16201 aattcgtttc cgatgaaacc gatcaaacct gccgccgcta cccaaccgag gtgctcgatc
    16261 tcgaccgggt tgatcaatcg cctcaccgcc tcgacaccgg cgatcactgc cgacagtgcg
    16321 atcatggcga gcacgaacag tccggccaaa tcctccgcac gcccgaaacc ataggtatag
    16381 cgcctggtcg cagcgcgccg accgagcgcg aaggcaatcc agagtgggac tgccgtgagc
    16441 gcgtcggaga agttgtgaat ggtgtccgcc agcagcgcca ccgaacccga gatcgccacg
    16501 atcgcaacct gagcaactgc ggtgactccg agcgcgacaa gactgatctt gaccgcccgg
    16561 atgccgattg cgctcgattc caatgcgtcg tcgacactgt cggcagcgtc gtgactgtgc
    16621 ggcgagaaca cttcgcggac tgccgatcga aatcccttcg gcccgtggcc atgggtgtgg
    16681 ccgtggccgt gggacgtctt gggttcgtgc gtcatgacgc accttcttct tgatcggtcc
    16741 gatcgacgtt cgccgagcgc tccgggtgta tctcccgaag ctcaccttca ctacggtgat
    16801 gccccggcaa tccgggtccg gcatgctccg cattgaagac cgcgtccgta accagttggc
    16861 gcacatggtc gttctccagg cgatagaaca ccgtcgtacc atcgcggcgg gttcgtacca
    16921 accttgccat gcgcaatttc gccaggtgct gcgacaccga gggcgccggc ttgccgacgc
    16981 gttccgccag ttcgttcacc gagcactcgc ggtcgaccaa tgcccacaag acctgcacac
    17041 gggttgcgtc ggccagcatg cggaacacct cgacgacgag gtcgacttga tcatcgggaa
    17101 gcttgcggcg acaaacacca ctatctgcgt tcatacgtag atagtagatc atgctggacg
    17161 ccgaagatga cctctcgtcg attcaccagt tgtgcaaagc ttggcggcag agcccttcgc
    17221 cactcgcaga ccgggagaca acgatgagta ccgacgattg gaacgcagga atcattgcgg
    17281 aatttcggga gaacgagggc aaggtaggcg gccccttcga aggtgcgccc atggtgttgg
    17341 tccaccacac aggacgcaaa tccggacgcg atttcgtgag tcccatgatg tatctggcag
    17401 acgagcagga tccgaagacc atctacgttt ttgcatccaa ggccggtgcc ccgaccaatc
    17461 ccgactggta ctacaacctc gttgccaccg accaggcaga ggtcgagatc ggcaccgaaa
    17521 catacccggt ctccgtcagc gaagtaaccg gcgagaagcg tgaccgcatc tacgacgaac
    17581 aggccagtcg atacccggga tttgccgaat acgcggagaa gacagctggg atccgcacaa
    17641 ttccggtggt ggcactgact cgcgcgtaaa tcctgatcgc gcctccccgc cgtttccatc
    17701 cggaaacggc agggatcgtt tgtacggaat cacgacactg aagacgcttt gacctcagcc
    17761 ttcgaatgcc gtccgagcag cacgtatccg acccaggatc cgacaaccac tgtcgccgcg
    17821 agcgcctgta ccaggccttc gatactcgcc ggatagaaca cgccggtgat gtagtgcgag
    17881 atgaatccgg tggacggcaa ctccgcgatc ccggccatcc ggcgggccca gttctcgaga
    17941 ttggtcagcg ggcagtcata tccgaccgct atcgaaccgg ctccccagac gactgcaaga
    18001 aggtgaaaac cgatggtacg acgccacttc cacgccacga acccacccag caccacatag
    18061 aggacaaacc cgaagtgaac gaacaccgtc actacttcga tgagccgata caccatcgtc
    18121 gtctccgctc gtggcgcgga agtcccgcaa caaccagact aatccgatgt tagtcctcgt
    18181 agaggtgatc tacccggtgt atgcagcggt cgtgcgagca gcggcggctg cagccgcatc
    18241 cgggtcgtcg cccgatgcga tcgcagcttc ggcccacagt tcactgcttc ccgcgatgaa
    18301 tgccttggcc tcgtcgctcg ccgaccactc gggtgtctcg agtggcgtcg cgatccccag
    18361 ttccacgtgt cgagccagcc cgagcagtcc catgtcccac ccgacgccga cggcacctgg
    18421 accgtactcg gcccaccgat ccggctccac gtccgcggcg tgtgcgaagt cgaacagaat
    18481 tgcacgacgg cgctccttgg ttcgggaaaa cttcagctca ggcgctgctg tagatgtacc
    18541 gctacctctt ctccagcggc gctcttgccg atcgccttgc acagcgccac gcgcagcgga
    18601 agccagtgcg gtccgtcgcc ggagggcatc agcgtcgcct cgaagggatg ctcaccatcg
    18661 agggttccga gcaccttcac agcgcgtctg gttcccagaa gttccgccga gccgggcacg
    18721 gtcaagaacg ttgcgaacgc accgtctttc tcgatgggag cggtgaacga gtaatcgagc
    18781 ggttgtggag tcttgtcagt ggccatctcg cgtcactgtt cagcagcgag caggacgtcg
    18841 gtgtcgaaac acgtgtgagt gccggtgtgg cacgcggcgc cctcctgatc gacgatcagc
    18901 aagacggaat cgccgtcaca gtcgaggcgc acctcgtgca cgtactgggt gtgcccggag
    18961 gtctctccct tgacccagta ctgctgccgc gagcgcgaat agtacgtccc cttacgggtt
    19021 tccagtgttc gcgcgagcgc ttcgtcgtcc atccatgcga ccatcagcac atcaccggtc
    19081 gacttctcct gcgcaaccgc gctgaacagt ccggcgtcgt ttcgcttcag cttcgccgcg
    19141 attgcgggat caaggctcat atgacgttta taccttccac ctgcgacttc cgtggaattc
    19201 ccctgcacgg ccgccctaga atggaagttc cttcgctgtc accgtggaag aagatccgac
    19261 atgaaccatc agcatcatga cggtccgcac ccggagtaca cctgccatct cgcgaacccg
    19321 agtaccgatc gcgtccgaac ccgccacgtc gttctcggca tcggcccagg tgctaccagc
    19381 aagaatgtac tcagctacgc actgacgctt gccgccaagg aggattcagc cctccacgtc
    19441 gttcactgca tcacgtccga ggacctacct gtcgaaaccg actcaccaga attcgaaacg
    19501 cgtctgcacg acgagatggt gtcgcaacgc gagcagacaa cctcggcact tgcctcgcac
    19561 gccgacacct ggacgtacga ctgcacctat ggagacccgg ccggtgtcat tctcgcaacc
    19621 gcggacaaat acgacgcatt taccatcgtg atcggatctc cgcgaaaagg cgctgcctcc
    19681 gcggtgagcc gactgatgca catctcggtc acttcccgac tgaaccggca gaaccgttat
    19741 cccgtgatat cggttccgac cggagtcagc tcggcaagat agccgaacgc gggacaagcc
    19801 cgcctagatg atcgaatagt cctcgagcgg aaagcgtttc gcttcgacga acgcattccg
    19861 tgtagacgtg ggccgcagaa tcgcagcctc gccgtgctga ttgaagtaat agcttcgtgc
    19921 agtctggcaa ctaccgccgt agaagacgga gtccgccagg ttctcggtca tccggtcgag
    19981 gaactcggcg ttggcagttt cggtgacctc gaatgtttcc gcgccgcgcc gtttcacctc
    20041 gccgaacagt cgatccatgt gctgcatctg ggattcgatc gtcgtgaagt aggacaaccc
    20101 gctgtacgag tacggactgg cgagcgtgag gaagttgggg aaatacggaa ccgcgacccc
    20161 ttcgtaggcc tggaaacggt tgtcgcgcca ccacttaccg aggtttcgtc cctcgcgacc
    20221 gataacctcg atggctggaa agttcacatc ccagaggttg aatcccgttg ccagcaccaa
    20281 ggtgtcgatc tcggtcttgc gaccgtcggc ggtgacgatt ccgtcggcag cgatgtggtc
    20341 gatcggcgtc gtttcgagat gcacgttgtc cttggtgaac gtacggaagt agctgttgga
    20401 aaatgtggga cgcttgcacc cgaagtcgta gtccggtgtg agttgtttgc gaaggctggc
    20461 gtcgctgacc tgggaccgca gaaacgcacg tgatgcggcc gccgcaccct tgttcaacag
    20521 tttgacctgc ttgtagtgaa ggaccgcgct gaccatgatc atttctagga tcgacgaact
    20581 gacagcgcgg gcgattcgct gggtgagcgg aatacgcgag aacagcttct gcactgcatt
    20641 cggaatgggg acgtcgatct tgggaaccac ccagatcggc gtgcgctggt agacggtcaa
    20701 ctctgcggcc tgacgcgcca cctcggggat caactgcaca gcggtggcgc cggttccgat
    20761 gattgcggtc ttggtgccgg acagatcgta ggaatcgtcc caggccgtgg tgtggatgat
    20821 cttgccggcg aagtcgccga taccggagat gtcgggccga cgcggttgcg agaggaaacc
    20881 cgtcgcagtc aggaggtact tggcagtgat gtccggcgcg ccttcgacgg atacgaccca
    20941 gtgcgaggaa tcctcgtccc agcgggctcc gttgaccacg gcaccgaacg tcatgtgctt
    21001 ccgcagatcg tacttgtccg cgacgtgatc ggcgtacttc ttcagttccg cgcccggtgc
    21061 gaaaagcctg gaccagttcg gattgggctc gaacgaatac gagtaggtga ccgacgcgat
    21121 gtcgacagcc agaccgggat agcggttgac gtgccaggtt ccacccagat cgtcctcgcg
    21181 ctcgaggatc gccaggttgt tcaggcccag ccgcttgagt tgaatggccg cacccattcc
    21241 gccgaagccc gcccccacta ctactgcgtc gtactgcact gccatcggag aatccctctc
    21301 gtgaactgca catcagaaaa actgcacatc agaaactgac acgtcattcc gttattgaga
    21361 acggtatcat tcctgatgtg acgaaggcca tgaccagagc ggaacgaaaa aaggcggaat
    21421 tgcgccgcga gatcatcgac gcatcattcg agtgcttcgc ccagcgcggc tatcacgcaa
    21481 ccggaattgc cgacatcgca acaactctcg gaatcggcca tgggaccttc taccggtact
    21541 tcgagaacaa gcgcgacatc atcgatcacg tcatcgacga cctcgtcgca aagatcatca
    21601 gcgcactggc caccgagaat gctcccgacg ccgccagcac actggacgag taccgcgccc
    21661 aagtgggacg gatcgccgag gcgctccccc gcatcttctt cgacgacccc cgcatcccgc
    21721 gggttctgct gttcgagacg acgggcgtcg acgccgatct gacgggccgg atgctcgatc
    21781 tactcgacca gtcggcatcg ttgaccgcgg cgtacctgca ccacggagtc gaatgcggct
    21841 atctacgcgc cgacctcgat gtcgacaaca ctgcccacgc cgtcaacggc atgatgctgg
    21901 caagtgcgat tcaaggattg cgagccggtt cgtccgtcga ctgcacggcg ttgaaccaag
    21961 ccatcagccg cctcatgttc gacggaatcc gcgccgagaa cgcctagcga acgacgattc
    22021 cctcggcacg catcgcatcc ttgacctccg ggatgctcag atcgccgaag tggaagacac
    22081 ttgctgcgag aactgcgtct gcgcccgctt cgactgcagg ggcaaagtgc tcgaccaggc
    22141 cggcaccgcc actggcgatc accggtacgt ggactgccgc ccggacagcg cggatcatca
    22201 gaaggtcgaa gcccgctttg gtgccgtcgg catccatcga gttgagcagg atctccccca
    22261 ctcccaactc tgcaccacgc tcggcccact cgacagcgtc gatcccggtg ccgcgcttgc
    22321 ccccgtgcgt cgtgacctcc caccccgacg gtgtgtccgg ctgcccctgg ggaacggtgc
    22381 gggcatcgac cgagaggacg atgcactgcg agccgaaacg ctcactcagt tccttcagca
    22441 gttccgggcg cgcaatcgcc gcggtgttga cgctgacctt gtcggcaccg gcacgcagca
    22501 gacgatcgac atccgcgacc gtgcgcactc caccgccgac ggtcagagga atgaaaacct
    22561 gctcggcagt gcgacttacg acgtcgagca tcgtgccgcg atccgacgtg gaggcggtca
    22621 cgtccaggaa ggtcagttcg tcggcgccct gagcgtcgta cgctgccgcg agttccaccg
    22681 gatctccggc gtcgcgaaga ttctcgaaat tgacaccctt gaccactcgc ccggcgtcga
    22741 cgtcgaggca cggaatcaca cgaactgcga gggtcatgac tgtggtcctc ctgaggacga
    22801 agcgcgcgga tcaccgagcg cgttgaggat atcgagaatc tcaccgtgga tgcccggagc
    22861 ggcagcgagc accgactccg attctacggt ccacgggcgg ccggccaggt cggtgaccac
    22921 cccgcccgca ccgcgaacga gcgcgacccc ggccgcgttg tcccacgcgt tgcggccgta
    22981 gacgatcgca ccgcccagga tgccggccgc ggtgaaggcc agatcgactc cggtggaacc
    23041 gtgtatccgg atccgcgagg acaccttgct gatctcggcg aggaggtcga gacggaaact
    23101 gccggggatc cgccctcgac tattgacgtt gagcgcaccc aagccgacga tcgacgacgc
    23161 cagatcggtt ggctccagcg gcggtacggc gattccattg accaacaacg gaccgccggc
    23221 gcgagtcgcg tacgtgtgac cgatcaatgg aagccaggtc aatccgagca ccgggacacc
    23281 gtcgtcgaga agcgccaaca gcgttccggc agtgggcaat ccggccgagt agttgaaagt
    23341 accgtcaacg gggtcgagaa cccagacgag cccggaaccg acgtcgggac cgccgaattc
    23401 ctcgccgtgc acctcgatgc cggtctgctc gaacaactcc gcggtcaacc gcttctcgag
    23461 cgcaagatcg acctcggtgg caaaatcacc ccagcccttg cggaccgcac tcggggcgcc
    23521 gacaccggag acgaactgat cgtggacgcc gtcgagaagc cgacccgcaa tcgcgagaag
    23581 ttcgtcgagg tcacgcgtcg gagtcatctg gaaaatctat ccggaaactg ctgccagtgc
    23641 ttcggggaga gtgaagcgac cggcatacaa tgccttgccc acgatcgcgc cctcgacacc
    23701 ctgatcaacc aggctggaaa tggcgagtag atcctcgatg gtcgacacac caccggaggc
    23761 gacgacgtgc gcgtcggtga ccgcgcacac ctggctgaga agttcgagat tgggaccggt
    23821 gagtgtgccg tccttggaga cgtcggtgac gacgtaacga gtgcagccgt caccgtccag
    23881 acgcgcgagg gtctcccaca gatcgccgcc gtcggtgacc cagccgcgac cacgggtgcg
    23941 gtactgaccg tcgacgagac gaacatcgag gccgacagcg atcttgtcgc cgtacttggc
    24001 caatgcacgc gcacaccact cgggatcctc gatagcggca gtaccgagat tcacgcgagc
    24061 acagccggtg gccagtgcgg cttccaggga agcgtcgtcg cggatcccac cggacagttc
    24121 caccttgacc gtcaggtcgc cgatgacgcc ggccaacagt tcactgttgg acccacgccc
    24181 gaaagcagcg tcgaggtcga caagatgcac ccattcggca ccgtcgttct gccacgcaag
    24241 agcagcgtcg cggggcgacc cgtaaccggt ctcacttccc gcctctcctt gcacgaggcg
    24301 aacagcttca ccgttgacga catctacagc aggcaaaagg accaggctca cgtgcggtaa
    24361 ccctagtagg tcaggacctc gaaccgtctt ccgggtcacc gaacgctttt cgggtcatcc
    24421 gcttggatac gacgcccatt gccgcaatcg cagcgacgac ccccacgaga ccgatcacga
    24481 ggccgacgcc cggcgatggt ttgagaacaa cgatgacgac agttgcgacc gccagcgcag
    24541 ccacagcggc gccgagcgag aacaacgcca gacgggcgag ggagaaatcg tcaccgcggt
    24601 tcggtccgga tcccccggtc acaaactctg cacccagttg ctcagcaact cggcgcctgc
    24661 gtcaccggat ttctcggggt ggaactgcgt tgccgacaac gcaccgttct cgacggcagc
    24721 gaggaacttt ccgccgtgat cggcccatgt cagcttcggg ggtgcaatgt gctcggacgg
    24781 cgcgagctcc caactctgca caccgtagga gtggacgaag tagaagcggg tatcggcgtc
    24841 tatgcccttg aacagggtgc tggactccgg agcctccacg gtgttccagc ccatgtgcgg
    24901 caggacctct gcttgcagcc tctccacggt gccgggccat tcgccacagc cctccgcctc
    24961 gacaccgaat tcgactcccc ggtcgaacaa aatctgcatg ccgacgcaga tgcccagcac
    25021 cggtcggcca ccggccaggc gtctgccgat gattcggtca ccctgcactg cacgcagacc
    25081 ttccatgcag gccgcgaacg cgccgacgcc gggcaccacg agaccgtcgg ccgccagtgc
    25141 aaccttcatg tcgttggtca cctccacctg cgccccggtg cgcgccagtg cgcgagtagc
    25201 cgaatgcagg ttgccggagc cgtaatcgag tacagcaatc gtggaagcgc tcatgcccca
    25261 actctatcgg gcaaccctgc tgccgatcac tttgccgccc gcggccagtg ccgggagcag
    25321 agcgacaacg accgcagaga ccgcgaagac ccacgcatag ccggcagtcg tggccacgaa
    25381 tcccaacgcc agtgcaccga ttccggtgcc ggcgtcgtag ccgatgttcc agatcgcgct
    25441 ggcggatc
//
