LOCUS       NZ_JAPWIK010000002     22583 bp    DNA     linear   CON 14-FEB-2024
DEFINITION  Rhodococcus qingshengii strain IEGM 766
            NODE_2_length_1167099_cov_313.895192, whole genome shotgun sequence.
ACCESSION   NZ_JAPWIK010000002
VERSION     NZ_JAPWIK010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Rhodococcus qingshengii
  ORGANISM  Rhodococcus qingshengii
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Rhodococcus; Rhodococcus erythropolis group.
REFERENCE   1  (bases 1 to 1167099)
  AUTHORS   Krivoruchko,A.V. and Elkin,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-DEC-2022) Lam, Institute of Ecology and Genetics of
            Microorganisms, Ural Branch of the Russian Academy of Sciences,
            Golev Str., 13, Perm, Perm Kray 614081, Russia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2022
            Assembly Method                   :: SPAdes v. 3.15.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 311x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/14/2024 02:58:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,449
            CDSs (total)                      :: 6,385
            Genes (coding)                    :: 6,320
            CDSs (with protein)               :: 6,320
            Genes (RNA)                       :: 64
            rRNAs                             :: 1, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 5 (23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 17 of 65
            Pseudo Genes (incomplete)         :: 52 of 65
            Pseudo Genes (internal stop)      :: 6 of 65
            Pseudo Genes (multiple problems)  :: 9 of 65
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:17:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 212089
            Orig. end                         :: 234672
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPWIK010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22583
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22583
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22583
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12583](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12583)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(507..1697)
                     /locus_tag="O4271_RS07125"
                     /old_locus_tag="O4271_07125"
     CDS             complement(507..1697)
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730416.1"
                     /locus_tag="O4271_RS07125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07125"
                     /product="lipid-transfer protein"
                     /protein_id="WP_030536146.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 8e-07, bitscore:
                     24.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDVAVLGVGMHPWGKWGQSFVKYGVAAARAALADSGVNWQDVD
                     FIVGGETVRNGYGGYVAGATFAQALGWNGARVATSYAACATGAQALDTARARILAGLSE
                     VALVVGADTTPKGFLAPVAGERWDDPDWLRFRLMGMTNPAYFALNARRRIDLYGATAED
                     FANVKVKNARHGLSNPNARYRKEVTVENVLASPVVSNPLHLLDICATSDGGAAILLTSM
                     EYARKMGIAEPVRIKAISTVTPTFPQTIMDMPNFSTDSSSAVPAPERTFKESIGYAAYE
                     EAGISPEDVDVAEVYDLATSVELDWIEDLALCKRGEAEHLLRAGDTSIGGRIPVNPSGG
                     LACFGEAVPAQALAQVCELTWQLRGQAEGRQVEGARIGITANQGLFGHGSSVIVSA"
     gene            complement(1694..2170)
                     /locus_tag="O4271_RS07130"
                     /old_locus_tag="O4271_07130"
     CDS             complement(1694..2170)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003943075.1"
                     /locus_tag="O4271_RS07130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07130"
                     /product="OB-fold domain-containing protein"
                     /protein_id="WP_037126255.1"
                     /transl_table=11
                     /translation="MSETATPAPNGSVTPAVEGWFTTGDEPALIGTKCQSCGTISFPRE
                     ATFCKNPSCFSEEFDDVELSRSGTVWSYTDAQYQPPPPYIPRSDPYEPFALAAVELPEG
                     IVILGQVADGFGVDDLKVGNTVELVVEPLYTDETGVRTTWRWKPVAAADQELQS"
     gene            complement(2381..4108)
                     /locus_tag="O4271_RS07135"
                     /old_locus_tag="O4271_07135"
     CDS             complement(2381..4108)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1285: ferredoxin fdxC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019745838.1"
                     /locus_tag="O4271_RS07135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07135"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_116057719.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.9e-08, bitscore:
                     30.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPHVVTQSCCSDASCVYACPVNCIHPTPDEPDFLTAEMLHIDPQA
                     CVDCGACVSACPVDAIVPESKLTDPQRVFLSINSDFYKEERPRPLLAKVIPAAHVDKGR
                     PPLRVAIVGSGPSAMYAADELLTQPDVQVNVFDRLPVPYGLVRAGVAPDHQKTKQVTRL
                     FDKIAAQKGFEFYLNVEIGKHISHSELLENHHAVLYAVGASSDRGLGIPGADLPGTASA
                     TDFVAWYNGHPDHADDVFDLSHRRAVIIGNGNVALDVARILTADPEKLAGTDISAHALA
                     ALRKSRVEEVVIVGRRGIAQSAFTVPEFTGLMALPDIELSVGPDDMVLDSATEELAKRG
                     ELPHAVEQKLRLLEALKNRDHVDVGNKRITLRYLLTPTSITGDDQVSGIEFARNALVDA
                     NGTVQIEATGDTETIDTGLVLTSIGYRGVPIPGVPFDERASVIPNENGRVLEAPNGDPA
                     TGVYATGWIKRGPSGFIGTNKSCAQETIRMLVDDFNDGRLTNPVADDSAVDRLVRARQS
                     DVVDREGWHAIDKAELERGAAHDRAREKVLDQVEITSILDAAARVKPTRRFGRPVRVR"
     gene            complement(4142..5149)
                     /locus_tag="O4271_RS07140"
                     /old_locus_tag="O4271_07140"
     CDS             complement(4142..5149)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AurF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003943163.1"
                     /locus_tag="O4271_RS07140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07140"
                     /product="diiron oxygenase"
                     /protein_id="WP_003943163.1"
                     /sec_met_domain="AurF (E-value: 1.9e-114, bitscore: 377.7,
                     seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTSPLDKRGEASDDSYNETLRLLSEGSVHKHFDPYLDIDWDSP
                     EFAVVPNDRRWILPAETDPLGAHPWYQSQSEARQIEIGMWRQANVAKVGLQFENILIRG
                     MMQYVFSLPNDSAEARYCTHESVEECNHTMMFQEMVNRIGADAPGMSRPMKMLAPFIPL
                     AAGPFPELFFVGVLAGEEPIDHIQKSILRAGGQIHPIMQSVMAIHVAEEARHISFAHKL
                     LSRRIPLMSRPNRFVLSLLFPIVMRILCDAIVIPPKSFWKQFDIPKSVKKDLFWDLPES
                     RQTLRNYFGDVRMLATDTGLMNRASRLVWKACKMDGRASRFRSEPHRSSHNAAA"
     misc_feature    5336..5350
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.78"
                     /tool="antismash"
     gene            5367..6269
                     /locus_tag="O4271_RS07145"
                     /old_locus_tag="O4271_07145"
     CDS             5367..6269
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730424.1"
                     /locus_tag="O4271_RS07145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07145"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_081305497.1"
                     /transl_table=11
                     /translation="MGCSGTGSHRIAREDRTEADVIRSILSNLALRPPTRLRSLVPSRG
                     VTLSDKTIVLTGASSGIGEATAHLLARRGAEMILVARGEENLEHVRDEIHRRGGWAHIV
                     PADLSRGEAVDELAETIADRFGSVDILVNNAGRSIRRTALDSVDRFHDYERTMALNYFG
                     PTRLTLRLLPAMLEAKSGHIINVGTWGVTAGVMPRFSAYHASKSALSAFGRSLGAECHG
                     TGVDVTTVQFPLIRTPMIAPTADYVSQPALTADQAASWILRAINTRPVELYPRYAGLLR
                     AIDVVSPSATDALVRRAGI"
     gene            complement(6366..7604)
                     /locus_tag="O4271_RS07150"
                     /old_locus_tag="O4271_07150"
     CDS             complement(6366..7604)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019745836.1"
                     /locus_tag="O4271_RS07150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07150"
                     /product="HNH endonuclease signature motif containing
                     protein"
                     /protein_id="WP_142006261.1"
                     /transl_table=11
                     /translation="MDSRDAWQLDGEGLKGEVLDLVRARHELQSRMVLLIVEMFSRDVL
                     GGKGFRAIAQWLHGSTNLEIGECSLLVGLARLLMLEPVVGDAFHRGDVDALKARQVASF
                     CQHPPKNMTPTDVDKARRILLGLASQNIADCDAVRAAIRRIEKQYGKREDGIPVGEDSE
                     RNEFYASKGLYGRVTVKGDLDAINGARLITLLSSLSAPTPEKDGVKDTRTPALRRADGF
                     CELLRRYERAGLGPIEGGVKPHITVTASAKDMTDLQALKDLLPSTQELGFAWTDWVGPI
                     SIDTARMLACDCTVTRILLDENGVPLDCGKEARTATVPQRRALAVRDGGCAFPGCGTSS
                     GWCDAHHIVHWNDGGPTDLDNLVLLCGHHHRTMHHTEWRVEIGPDRKTVFYPPMSIDPY
                     QQPIGGNSPPTAA"
     misc_feature    complement(7618..7633)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.95"
                     /tool="antismash"
     misc_feature    7619..7632
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.58"
                     /tool="antismash"
     gene            8708..9331
                     /locus_tag="O4271_RS07155"
                     /old_locus_tag="O4271_07155"
     CDS             8708..9331
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730431.1"
                     /locus_tag="O4271_RS07155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07155"
                     /product="hypothetical protein"
                     /protein_id="WP_054186991.1"
                     /transl_table=11
                     /translation="MDQAVSNSQATRRSGALRWVVLVNALIAASASAMYVAAKCHLTWP
                     EPADSALSIAGAVVLWVLTASVAIVLLGVCWWQRRRWLWSDVAVPVLVVIALGIAAAGQ
                     PHFDQYRADFETVAQQLLQEPDDPYSDGYHRDLRIGRFDISYANVSSEGHVYFYDARDG
                     LDILDNPGWVYAPDGVSDKTFNQLRLEDIGGGWYRFPHLVVDSY"
     CDS             complement(9750..9869)
                     /gene="allorf_0221839_0221958"
                     /locus_tag="allorf_0221839_0221958"
                     /protein_id="allorf_0221839_0221958"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTMDAILSLQDLSVAAGNVGDAGQLEQNAAISSLSFFCL"
     CDS_motif       complement(9807..9869)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTMDAILSLQDLSVAAGNVGD"
                     /locus_tag="allorf_0221839_0221958_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9750..9806)
                     /prepeptide="core"
                     /locus_tag="allorf_0221839_0221958_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.20"
                     /molecular_weight="1845.1"
                     /monoisotopic_mass="1843.9"
                     /core_sequence="AGQLEQNAAISSLSFFCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTMDAILSLQDLSVAAGNVGD"
                     /leader_location="[9806:9869](-)"
                     /alternative_weights="1863.1"
                     /alternative_weights="1881.1"
     gene            complement(10001..12583)
                     /gene="lanKC"
                     /locus_tag="O4271_RS07160"
                     /old_locus_tag="O4271_07160"
     CDS             complement(10001..12583)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019745831.1"
                     /locus_tag="O4271_RS07160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07160"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_211921702.1"
                     /sec_met_domain="micKC (E-value: 2.4e-194, bitscore: 643.8,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.2e-14, bitscore: 49.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 2e-06, bitscore: 24.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.3e-06, bitscore:
                     21.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYVAFTRADPHFYDRIRTVTRPDTSTDQHFIPAKSVDWSLWR
                     RGPQSGPWNYFQPPDGLLPEQGWKIHCSATRANAQELLDTVSVYCGHNHVPFKFLRTAA
                     DLMLSNSKQANRTSSGKFITIYPADGVATQRVITELDKLVAGADGPYILSDVRWNRGPL
                     YLRYGAYLPMQTYDSFGDRVPAIRRPDGSLEPDVRGTSFRTPDWVQIPDFVRAQQDKLK
                     SHDEFPYSINEALHFSNSGGIYSAFDDAGIDLVIKEGRPFTAPDANGRYAIDRIRNEYD
                     KLTHLADNPYTPSAISLFEREGHHFLVTERAAGTPLNQEVALRHPLIRADQTLSSRTEY
                     RTWALDIAQQLTTAVESFHNAGIVHADLHPGNVMCSPSGIRIIDFEMAHNIDEHPPRST
                     GAPGYTAPRQLTGIAADRYSLGCIELGLFVPLTTLFPLDRNKIPELIDYAVSRFDLPRA
                     FGASLYSMLDVQAPAPKNRPHRWDTSSNETLQRTAALLRCGILASLDLARADRLFPGDI
                     AQFEVNGYGIAHGSCGNLLADVLPADTLESVLEWTEHQVDSDTQPKFGFFDGLAGAVHT
                     FRHHGRHSTADRWVETLRRAPLDDIDSSLFSGLSGIGCLLLEESVSRPTVSPTLAVVTE
                     TLRERISAARLHVRDAGGTPWAVAGRGGLMRGPSGQALFWTRHYELSGDPRSLEHARQL
                     VDIDLSVMSMCPDGSMQLREERRTMPYLGSGSVGVGLVLLQLLRHVDEPRYAAAVRAIS
                     RAATVEFTAQAGLLNGRAGLILFLSELSKTPYAGADCEQTLAQQFQLLGLHSLNHAGGL
                     HFPGEQNLRLSTDWATGSAGILALLRYTRSATARQSFPLMCASNCHIA"
     gene            12952..14145
                     /locus_tag="O4271_RS07165"
                     /old_locus_tag="O4271_07165"
     CDS             12952..14145
                     /EC_number="2.3.1.16"
                     /GO_function="GO:0003985 - acetyl-CoA C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005264857.1"
                     /locus_tag="O4271_RS07165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07165"
                     /product="acetyl-CoA C-acyltransferase"
                     /protein_id="WP_073513459.1"
                     /transl_table=11
                     /translation="MTKAVIVDVVRIASGKGKPGGALSGTHPVELMAHVLRSITSRNGL
                     DPALVDDVIGGCVGQAGEQALNITRSAVLSAGFPESVPATTIDRQCGSSQQAAHFAAQG
                     VIAGAYDIVIAAGVESMSRVPMGTTTMGKDASGPGVAARYPEGLVNQGISAELIAAKWK
                     LDRDALDAFSAQSHQRAAEAAAKGLFDKEILPISVTNAAGETVSHTVDETVRASTTAEG
                     LAGLKPSFYSEKYAQRFPEAQWSITPGNSSPLTDGASAALIMSEEMASKLGLTPRARFH
                     SFSVAGDDPIFMLTAPIPATHKVLARAGLSIDDIDTYEVNEAFAPVPLAWAHEFGADPA
                     KLNPWGGAIALGHALGSSGTRLLTTMVNHLEATGGRYGLQTMCEGAGMANATIIERI"
     gene            14174..14935
                     /locus_tag="O4271_RS07170"
                     /old_locus_tag="O4271_07170"
     CDS             14174..14935
                     /NRPS_PKS="Domain: PKS_KR (6-163). E-value: 4.9e-13. Score:
                     41.3. Matches aSDomain:
                     nrpspksdomains_O4271_RS07170_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003875437.1"
                     /locus_tag="O4271_RS07170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07170"
                     /product="3-hydroxyacyl-CoA dehydrogenase"
                     /protein_id="WP_003942978.1"
                     /sec_met_domain="adh_short (E-value: 8.7e-31, bitscore:
                     103.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVNDSVAVVTGGASGLGLATTKALLADGASVVIIDLPSSNGEAI
                     AKELGDRVRFAAADVTDEAAVTAALDVAESLGPLRVAVNCAGIGNAVKTVSKKGAFPLD
                     AFKKVIDVNLIGTFNVLRLAAERISKTEPIDGERGVIINTASVAAYDGQIGQAAYSASK
                     GGVVGMTLPIARDLASLLIRVNTIAPGLFKTPLLAGLPEAAQASLGQQVPHPSRLGDPS
                     EYGALAAHIVSNPMLNGETIRLDGAIRMAPR"
     aSDomain        14192..14662
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS07170_PKS_KR.1"
                     /evalue="4.90E-13"
                     /label="O4271_RS07170_PKS_KR.1"
                     /locus_tag="O4271_RS07170"
                     /protein_end="163"
                     /protein_start="6"
                     /score="41.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAVVTGGASGLGLATTKALLADGASVVIIDLPSSNGEAIAKELGD
                     RVRFAAADVTDEAAVTAALDVAESLGPLRVAVNCAGIGNAVKTVSKKGAFPLDAFKKVI
                     DVNLIGTFNVLRLAAERISKTEPIDGERGVIINTASVAAYDGQIGQAAYSASK"
     CDS_motif       14198..14266
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS07170_0001"
                     /evalue="7.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="O4271_RS07170"
                     /protein_end="31"
                     /protein_start="8"
                     /score="15.3"
                     /tool="antismash"
                     /translation="VVTGGASGLGLATTKALLADGAS"
     gene            14949..15575
                     /locus_tag="O4271_RS07175"
                     /old_locus_tag="O4271_07175"
     CDS             14949..15575
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730441.1"
                     /locus_tag="O4271_RS07175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07175"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_065455052.1"
                     /transl_table=11
                     /translation="MTGEVESVSSVAVDWRSFPPLVMTDILMASLELFDENGYHGTTVR
                     QIANHVGVTVPALYYHHANKEAILVALFEVSMSELNTRTEAAEAEAGENPVRRFALVVE
                     AIVLYMTHRSRHAALDTEIRHVSPESRSRYAASRKRLELLMRRIVDDGVASGDFAVTDT
                     EETVRAILGMAQSLPRWFQTGGPMSPSQLAEKYVDIAFHTVGYRP"
     gene            complement(15661..17283)
                     /locus_tag="O4271_RS07180"
                     /old_locus_tag="O4271_07180"
     CDS             complement(15661..17283)
                     /NRPS_PKS="Domain: AMP-binding (27-436). E-value: 7.1e-83.
                     Score: 270.4. Matches aSDomain:
                     nrpspksdomains_O4271_RS07180_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003943212.1"
                     /locus_tag="O4271_RS07180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07180"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_003943212.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-95, bitscore:
                     316.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSTMQDAPLSIAQLLRHGASVHGASEVVTWTESGPRRVSYADVG
                     KRCAQLAHALRGLGVEGDERVATFMWNNSEHLEAYLAIPSMGAVLHTLNIRLFPEQLIH
                     VANHAEDRVIIVDPSLIPLLSPQLPSLTTVKHIVVTGSSTAGLEAPEGVQVHTYEGLIA
                     DQPTEFDWPEVDELSAAAMCYTSGTTGDPKGVVYSHRSIYLHSMQVCMSDGPNLAQGDR
                     ALAVVPQFHAMSWGLPYAAFMIGASLIMPDRFLQPAPLAAIIASEKPTFAAAVPTIWQG
                     LHLYLEQNPQDISSMREVLIGGSAVPPALMHAFEADHNVSVLHAWGMTETSPLGSVARP
                     PAGVTGDAMWKYRYSQGRFPASVEARLIDDDGKVVAHDGVSVGELEVRGPWITGSYYGV
                     DAEDKFNDGWLKTGDVGSITADGFLSLSDRSKDIIKSGGEWISSVDLENAVMGHPDVTE
                     AAVIGVPDEKWDERPLVAVVLRAGSETTMSELQQYLSDKVAKWQLPENWAVVQEVPKTS
                     VGKFDKKRLRADYHEGGLEVTRL"
     aSDomain        complement(15976..17202)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS07180_AMP-binding.1"
                     /evalue="7.10E-83"
                     /label="O4271_RS07180_AMP-binding.1"
                     /locus_tag="O4271_RS07180"
                     /protein_end="436"
                     /protein_start="27"
                     /score="270.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VVTWTESGPRRVSYADVGKRCAQLAHALRGLGVEGDERVATFMWN
                     NSEHLEAYLAIPSMGAVLHTLNIRLFPEQLIHVANHAEDRVIIVDPSLIPLLSPQLPSL
                     TTVKHIVVTGSSTAGLEAPEGVQVHTYEGLIADQPTEFDWPEVDELSAAAMCYTSGTTG
                     DPKGVVYSHRSIYLHSMQVCMSDGPNLAQGDRALAVVPQFHAMSWGLPYAAFMIGASLI
                     MPDRFLQPAPLAAIIASEKPTFAAAVPTIWQGLHLYLEQNPQDISSMREVLIGGSAVPP
                     ALMHAFEADHNVSVLHAWGMTETSPLGSVARPPAGVTGDAMWKYRYSQGRFPASVEARL
                     IDDDGKVVAHDGVSVGELEVRGPWITGSYYGVDAEDKFNDGWLKTGDVGSITADGFLSL
                     SDRSKDIIKS"
     CDS_motif       complement(16687..16743)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O4271_RS07180_0001"
                     /evalue="4.50E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="O4271_RS07180"
                     /protein_end="199"
                     /protein_start="180"
                     /score="22.3"
                     /tool="antismash"
                     /translation="AMCYTSGTTGDPKGVVYSH"
     gene            complement(17385..19070)
                     /locus_tag="O4271_RS07185"
                     /old_locus_tag="O4271_07185"
     CDS             complement(17385..19070)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019745827.1"
                     /locus_tag="O4271_RS07185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07185"
                     /product="dihydroxyacetone kinase family protein"
                     /protein_id="WP_039973156.1"
                     /transl_table=11
                     /translation="MFMRSAKTFVPDALRGLIASTDDIAWNPDPGYLTRARPLPRGRVA
                     LVSGGGSGHEPMHAGFIGEGMLTAVCPGLVFSSPNALQIHEGSKAADAGGGVLHIVKNY
                     TGDVMNFGIARELLREDKIDTDVVLVDDDVATERADGSGPGRRGTAATIVVEKVCGASA
                     ARGDDLAEVTRIGQHVAHSARSMAVALRPCTLPGADEPSFDLPAGQMELGIGIHGERGT
                     ERVDALPAPELVRRLTDPIIKSLSLAEGDRVIAVVNGLGATHPLELQLLFAELGDYLDE
                     QGIHIERTLIGTFVTALNMAGASITLVRTDKEILELWDAPTKAPAWPNAIAREYTGMGT
                     RESFGPTFTPDTSRTAESSFVGSWIADWAEKVLDQEPALTDLDRRAGDGDFGTNMVAAL
                     DQLDISAIRDTYSTATIFDAVSQAYLGHAGGTSGALFGIWFRHFFRVAADSADSELDLG
                     AIAAAARAGLDNITSLGGARVGDKTMVDAIVPAVESLEQSVSSEADRDAALASAAEAAA
                     AGAESTETMLANRGRASYVGEAARGVVDPGALLIAWFFASAVGH"
     gene            19125..19988
                     /locus_tag="O4271_RS07190"
                     /old_locus_tag="O4271_07190"
     CDS             19125..19988
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730450.1"
                     /locus_tag="O4271_RS07190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07190"
                     /product="patatin-like phospholipase family protein"
                     /protein_id="WP_047269365.1"
                     /transl_table=11
                     /translation="MDGVKLGLVLAGGGVAGIAWETGFLLGLQDKSPDTAAALLTADVL
                     IGTSAGSTVSAQIASGVTLQELFDAQTAEATGEIDPKVDVEVLGQMFVDAIAGSQDRAE
                     QLRLLGEAAMRADTVEPAVRRAVIEARLPNRLWPDRELRIPAINAQTGELRVFGNADGV
                     ELIDAVGASCAVPGVWPVVVIEGERYMDGGMASGSNVHLAADCDVVVVLSPAADPAPNL
                     LGGSLREEIDVMTPLPVLPVFADDAVVEAIGTNSLSPTTRRPAAELGREQGRRTADEIA
                     AFLVTA"
     gene            19985..20839
                     /locus_tag="O4271_RS07195"
                     /old_locus_tag="O4271_07195"
     CDS             19985..20839
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730453.1"
                     /locus_tag="O4271_RS07195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07195"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_047269366.1"
                     /transl_table=11
                     /translation="MSAARIAVVVRPEQSPEDLVRHARYADEVGIDEVWLWEDCFFGGG
                     IATAATVLAETDRVGVAIGVLPTPMRNTAITAMEISALARVHPDRLRVGFGHGVQSWMR
                     QIGAKAESPLTLLREQFGAVERLLGGESVTVSGRYVNLTDVTLAWPPETVPQLLVGATG
                     PKTLALSGELAQGTVLSGGTTPDGVRRAIAHIGASDHEVVVYVICAFGSGGRERALAEA
                     AASGSESPEDAIAVGNAAEVAAAARRWVAAGATTVVLQPTVDEPDVREFIRFVAQEVQP
                     LVA"
     gene            complement(20841..21851)
                     /locus_tag="O4271_RS07200"
                     /old_locus_tag="O4271_07200"
     CDS             complement(20841..21851)
                     /NRPS_PKS="Domain: Beta_elim_lyase (6-289). E-value:
                     5.8e-77. Score: 250.7. Matches aSDomain:
                     nrpspksdomains_O4271_RS07200_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007730456.1"
                     /locus_tag="O4271_RS07200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O4271_07200"
                     /product="GntG family PLP-dependent aldolase"
                     /protein_id="WP_083056313.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.7e-07, bitscore:
                     24.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSYIDLRSDTVTKPDAEMRKAMADAEVGDDVLDHDPTMAALEE
                     EVAHTLGLPAALWVPSGSMGNLIALMLHLHRGDQFLAPEHSHVLGSELGTAAWLAQGMP
                     MALPHDGGPGRPTPETVVKAAGSPGPYFALNTTLLCLENTHNFAGGAVMNPTEWTKLVN
                     AARSRGLKIHLDGARLWNAAVALDVSPTELTSGADTVQVCLSKGLGAPVGSILAASPEL
                     ITEARRIRKMLGGGVRQGGVLAAAGIVALRSQARLSDDHDNAQRLASGLRERGWAVDEP
                     ATNIVLAATADPSVTVAQLAAVDVGAVTVAGKVRFVTHRDVSTADIDAVLSRVTF"
     aSDomain        complement(20985..21833)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O4271_RS07200_Beta_elim_lyase.1"
                     /evalue="5.80E-77"
                     /label="O4271_RS07200_Beta_elim_lyase.1"
                     /locus_tag="O4271_RS07200"
                     /protein_end="289"
                     /protein_start="6"
                     /score="250.7"
                     /tool="antismash"
                     /translation="DLRSDTVTKPDAEMRKAMADAEVGDDVLDHDPTMAALEEEVAHTL
                     GLPAALWVPSGSMGNLIALMLHLHRGDQFLAPEHSHVLGSELGTAAWLAQGMPMALPHD
                     GGPGRPTPETVVKAAGSPGPYFALNTTLLCLENTHNFAGGAVMNPTEWTKLVNAARSRG
                     LKIHLDGARLWNAAVALDVSPTELTSGADTVQVCLSKGLGAPVGSILAASPELITEARR
                     IRKMLGGGVRQGGVLAAAGIVALRSQARLSDDHDNAQRLASGLRERGWAVDEPATNIVL
                     AA"
ORIGIN
        1 tgcagtcgtt ggtgtacatc gcggcgtttg ctccggttca gggtgagccg gtgcagatca
       61 cgatcgatcc catcaggttt cctggcagcc aattgcttcc tccggctctg ggattgaaga
      121 tcgtcgacga tcctcacgcg atcggcggga agaacgccga cggctacgtc acggacgagt
      181 atttccattc cgtcttcgct caggatgttt ccgacgagac agcggcaacg atgttggcgc
      241 atcagaagtc tgcggctttg tgggcgaacc tcgagctcgg cgggccaccg tcgtgggcga
      301 acacaccgag ctggtatctg gttgccggtg aggatcgcgt gatcccagca tcggcgcagc
      361 ggttcatggc aaaccggatg ggcgcgaaca ccagcgaact cccgacctcg cacgcatcgc
      421 tggtttcccg gccaggggca gtggcagacg tgatcgtggc ggccgctcac gggtgagtgt
      481 gcgaccgcca cgaaagtaga acagggtcag gcggaaacga ttaccgagga gccgtgtccg
      541 aacagacctt ggttggcggt gataccgatg cgggcgcctt cgacctgacg gccttcggcc
      601 tgtccacgaa gctgccaagt gagctcgcac acctgcgcaa gtgcctgtgc gggaacggct
      661 tcgccgaagc acgcgagacc gccggacgga ttgaccggga tgcggcctcc aatactggtg
      721 tcacccgcac gcaggaggtg ctcggcctcg ccccgcttgc agagggcaag gtcttcgatc
      781 cagtccagtt ccacggaggt agcgaggtcg tagacttcgg cgacgtcgac gtcctcggga
      841 gagatcccgg cttcttcgta tgcggcgtag ccgatggatt ccttgaacgt gcgctccgga
      901 gcgggaacgg cggagctgga atcggtggag aagttcggca tgtccatgat cgtctggggg
      961 aacgtcggcg tgaccgtcga aatagccttg atgcgaacag gttccgcgat gcccatcttg
     1021 cgggcgtatt ccatcgacgt cagcaagatt gcggcgccgc cgtcggacgt cgcgcagatg
     1081 tcgagcaggt ggaggggatt ggacaccacg ggggaggcca acacgttctc gacggtgact
     1141 tccttgcggt agcgcgcatt cggattgctc agcccgtgcc tggcgttctt gaccttcacg
     1201 ttggcgaaat cctccgcggt ggcgccgtag aggtcgatgc gacgacgcgc gttgagcgcg
     1261 aagtacgccg ggttggtcat acccatgagg cggaagcgca gccagtccgg gtcgtcccaa
     1321 cgctcaccgg cgacgggagc gaggaagccc ttcggcgtgg tgtcggcgcc gacgaccagg
     1381 gcaacttcgc tgaggccggc caggattcgt gcgcgcgcgg tgtcgagtgc ctgggctccc
     1441 gtcgcacacg cggcgtacga cgtggcgacg cgagcgccgt tccagccgag tgcctgcgcg
     1501 aaggtggctc cggcgacgta tccgccgtac ccgttgcgga cggtctcgcc gccgacgatg
     1561 aagtcgacat cctgccaatt cacacccgaa tcggcgagcg cggcgcgagc ggccgcaacg
     1621 ccgtatttca cgaacgactg cccccacttg ccccaggggt gcataccgac accgagtact
     1681 gcgacgtcct tgctcatgac tgcaactcct gatcagctgc ggcgacaggc ttccatcgcc
     1741 acgtcgtacg tactccggtt tcgtcggtgt acagcggctc gacaaccaat tcgacggtat
     1801 tgccgacctt gagatcgtcg acgccgaatc cgtcggccac ctggccgagg atgacgatgc
     1861 cctcgggcag ttcgactgct gcgagagcaa aaggctcgta cggatccgag cgcgggatgt
     1921 acggcggcgg gggctggtac tgcgcgtcgg tgtacgacca gacagtgccg ctacgggaga
     1981 gttccacgtc gtcgaactcc tcgctgaagc agctcgggtt cttgcagaac gtcgcctcac
     2041 gagggaagga aatggtgccg caggattggc acttcgtgcc gatcagagca ggttcgtcgc
     2101 cggtggtgaa ccaaccctct actgcaggtg tcacactccc gttcggcgcc ggcgttgcag
     2161 tctcgctcat gcaatcctca tctggttggc gagcgtgatc cggggatcgt ggctcgctgt
     2221 gccgcttact ggaacaggtt gcagtattac acgatttcgg ccgctgacgg gcataaattt
     2281 tcgctgagtg ggacgttgcc ggaacgcaga cggccccgcc gggcagacga gtctgcaggc
     2341 ggggcggtgt gcgtgaaagt agctgtttac ctgtagtgga tcagcgaacg cgtacgggtc
     2401 gaccgaatcg acgcgtcggt ttcactcggg ccgcagcgtc gaggatggag gtgatctcga
     2461 cctgatccag aaccttttcg cgggcacgat cgtgcgcagc gccgcgttcc agttccgcct
     2521 tgtcgatggc gtgccagccc tcgcggtcga cgacgtcgga ctgtcgcgcc cggaccagac
     2581 gatcgactgc ggagtcgtct gcgaccgggt tggtcaggcg tccgtcgttg aagtcgtcga
     2641 cgagcatcct gatcgtttcc tgcgcgcagg acttgttggt gccgatgaac ccactcggtc
     2701 cgcgcttgat ccaaccggtc gcgtagaccc cggtggcggg atcaccgttc ggagcttcga
     2761 ggactcggcc gttctcgttc ggaatgaccg acgcacgctc gtcgaacggg acgccgggga
     2821 tgggcactcc gcggtagccg atcgaggtga ggaccaagcc ggtatcgatg gtctcggtat
     2881 cgccggttgc ttcgatctgc acggttccgt tggcgtcgac aagagcgttg cgagcgaact
     2941 cgattccgct gacctgatcg tcgccggtga tcgaggtcgg tgtgagcagg tagcgcaacg
     3001 tgatgcgctt gttgccgacg tcgacgtgat cgcggttctt cagtgcttcg aggagacgca
     3061 acttctgctc gacggcatgc ggaagctcgc cgcgttttgc cagttcttcg gtggccgagt
     3121 cgagaaccat gtcgtcgggt ccgacagaga gttcgatgtc cggcagtgcc atcaggccgg
     3181 tgaactcggg gaccgtgaac gcggactgcg cgattccgcg tcgacccacg atgacaactt
     3241 cttcgacgcg actcttccgc agagcggcga gtgcgtgagc ggagatgtcg gtaccggcca
     3301 acttctcggg atcggccgtc agaatgcgag cgacgtcgag cgcgacattt ccgtttccga
     3361 tgatgaccgc gcggcgatgt gagaggtcga agacgtcgtc ggcgtgatcg gggtggccgt
     3421 tgtaccaggc tacgaagtcg gtggccgagg ccgtgccagg cagatcagcg cccggaatgc
     3481 cgagaccacg gtcggacgaa gcgccgactg cgtagagcac cgcatggtga ttttcgagca
     3541 gttcgctgtg cgagatgtgc ttgccgatct cgacgttgag gtagaactcg aaaccctttt
     3601 gtgcggcgat cttgtcgaac aagcgagtga cctgcttggt cttctgatgg tccggagcaa
     3661 cgccggcgcg aaccaagccg taaggcacag gaaggcgatc gaagacgttg acctgcacgt
     3721 caggctgagt cagtaactcg tccgcggcgt acatcgccga cggtccggaa ccgacgatgg
     3781 caacgcgcaa cggcggtcgg cccttgtcga cgtgggctgc cgggatgacc ttggcgagaa
     3841 gcggcctggg ccgctcttcc ttgtagaagt ccgaattgat ggacaggaag actcgctgcg
     3901 ggtcggtcag cttcgactcg gggacgatgg cgtcgaccgg gcaggccgag acgcatgcgc
     3961 cgcagtcgac gcaggcctgc ggatcgatgt gcagcatctc ggcggtgagg aagtccggct
     4021 cgtccggcgt cggatggatg cagttgaccg ggcaggcgta gacgcacgag gcgtcgctgc
     4081 aacaggactg cgtgactacg tgtggcatgg cgctatgagt ccgatctcga ctgtccggga
     4141 gctacgcggc ggcgttgtgc gagctgcggt gaggttcgct acggaagcgt gatgcgcggc
     4201 cgtccatctt gcaggccttc cacaccaggc gcgaggcacg gttcatcagg ccggtgtcgg
     4261 tggccagcat gcggacgtca ccgaagtagt tgcgcagggt ctggcgcgac tcgggcagat
     4321 cccagaacag gtccttcttc acggacttcg ggatgtcgaa ctgcttccag aaggacttcg
     4381 gcgggatgac gatggcgtca cagagaatgc gcatgacgat cgggaacagc agcgagagga
     4441 cgaaccggtt cgggcgtgac atcagcggga tgcggcggct cagaagcttg tgcgcgaacg
     4501 agatatgacg cgcttcctcg gctacgtgga tggccatgac cgactgcatg atcgggtgga
     4561 tctggccgcc ggcgcgcagg atgctcttct gaatgtggtc gatcggctct tcaccggcga
     4621 ggacaccgac gaagaacagt tcggggaacg gacccgcagc gaggggaatg aagggcgcaa
     4681 gcatcttcat cggacggctc atcccgggag cgtcggcacc gatgcggttg accatctcct
     4741 ggaacatcat cgtgtggttg cactcttcga ccgactcgtg cgtgcagtag cgcgcctcgg
     4801 ccgaatcgtt gggcagtgag aagacgtact gcatcatgcc gcggatcaga atgttctcga
     4861 actggagacc gaccttcgcg acattggcct ggcgccacat gccgatttcg atctgcctgg
     4921 cctcggactg cgactggtac cacgggtgtg cacccagcgg gtcagtctcg gccgggagga
     4981 tccagcggcg atcgttcggg acgacggcaa actcggggga gtcccagtcg atgtcgaggt
     5041 acgggtcgaa gtgcttgtgc accgagccct cggacaggag tcgaagcgtc tcgttgtacg
     5101 agtcgtcgga tgcttctccg cgcttgtcga gcggcgatgt gagcgtcatg gcgtctcctc
     5161 ttcgtttcgg tcaccgctgg tatttctcgc ggtgttcggt ggaatcgagg gccggttgtg
     5221 tgatcgctgg cactcggtct ggatttaatg taacccgagg tatcaggaaa agctagtggc
     5281 agatactcct gaatcccgac gaattcttga cacggccgaa acggcgccat aacttacttt
     5341 tgagtaattt ccgcggtgcg tccgaagtgg gctgttcagg gacgggttcg caccgaatcg
     5401 cacgcgaaga tcgaaccgag gccgacgtga tcagatcgat tctcagcaat cttgcattga
     5461 gaccgccgac gcgtctgcgc tcacttgttc cgtctcgcgg cgtcacgctt tccgacaaga
     5521 ccatcgtcct gacgggagcc tcctcgggga tcggtgaggc gacagctcat cttttggctc
     5581 gtcggggagc cgagatgatc ctggttgcgc gcggtgagga aaacctcgaa cacgtacggg
     5641 acgagattca ccgcagggga ggatgggcac acatcgtgcc tgcggacctc tcccgcggtg
     5701 aagccgttga cgaactcgcg gagacgatcg cggatcgatt cgggtcggtc gacatcctcg
     5761 tcaacaatgc gggtcgctcg atccggcgta ccgcgttgga ttcggtcgac cgattccatg
     5821 actacgagcg caccatggcg ctgaactact tcgggccgac aagactgacg ttgcggctac
     5881 tgcccgcgat gctcgaggcg aagtccggac acatcatcaa cgtcggaacc tggggagtca
     5941 ctgcgggcgt gatgcccagg ttcagcgcct atcacgcgtc gaagtctgct ctcagtgcat
     6001 tcggccgaag cctcggcgcg gaatgtcacg gcaccggtgt cgatgtcacc acagtgcaat
     6061 tcccactcat acgaacaccg atgatcgcgc cgacggcgga ttacgtgagc cagccggcgc
     6121 tgacggccga tcaagctgca tcgtggatct tgagggcgat caatacgcgt cccgtcgagc
     6181 tgtatccgcg gtacgcgggg ctgttacgag cgattgacgt tgtatcccct tctgccactg
     6241 acgctctcgt gcgaagggcc gggatctgag gggctgggat ttgaggggtt gggatctgac
     6301 cagaaacgtg caccagcacc ggggcatggt tcgtccccgg tgctgatgta ttcgattgtc
     6361 gcggttcagg ctgctgtggg tgggctgttc ccgccgatcg gctgttgata cggatcgatc
     6421 gacatgggtg gatagaacac cgtcttccga tccgggccga tctcgacacg ccactcggtg
     6481 tggtgcatcg tccggtggtg atgaccgcac aacagaacca ggttgtcgag atctgttggg
     6541 ccaccatcgt tccagtgaac aatatgatgg gcatcgcacc accccgacga agtcccgcac
     6601 cccggaaacg cgcacccgcc atcccggacg gccagtgctc gcctttgcgg aaccgtcgct
     6661 gttctcgctt ccttgccgca gtcgagcgga acaccgttct catccaacaa aattcgcgtc
     6721 acggtgcagt cgcacgccaa catccgcgcg gtatcgatac tgatggggcc cacccaatcc
     6781 gtccacgcga aacccagttc ctgagtcgac ggcaagaggt ctttcaacgc ctgcaggtcc
     6841 gtcatgtctt tcgccgacgc agtcaccgtg atgtgcggtt tcaccccgcc ctcgatcgga
     6901 cccaaccccg cccgctcgta ccgccgcaac aattcgcaga acccgtccgc ccgtcgtaat
     6961 gccggcgtac gggtgtcctt cacgccgtcc ttctccggcg tcggcgcaga caggctcgac
     7021 aacaacgtga tcaaccgggc cccgttgatc gcatccagat cccccttcac agtgacccgc
     7081 ccgtacaagc ctttcgaggc gtagaactcg ttacgttcgg aatcctcgcc gaccgggatg
     7141 ccgtcctcgc gcttgccgta ctgcttctcg attcggcgga tcgctgcccg cactgcatca
     7201 caatcggcga tgttctgcga cgccaggcca agcaggatcc tgcgggcctt gtccacatcc
     7261 gtcggggtca tgttcttcgg tggatgctga cagaacgacg cgacctgccg ggctttcaac
     7321 gcatccacgt caccacggtg aaacgcatcg cccacaacgg gttcgagcat caacaaccgc
     7381 gccaacccga ccagcagact gcactcaccg atctccagat tcgtcgaccc gtgcaaccac
     7441 tgcgcgatcg cccgaaaacc cttcccgccg agaacgtccc gggaaaacat ctccacgatc
     7501 agcaacacca tccgcgactg caactcgtgc cgggcgcgca ccagatccag aacctccccc
     7561 ttgaggccct cgccatccag ctgccacgca tcccgactgt ccatgccgaa agcataatcg
     7621 aacaaagttt cgaacacaag agaatgtgga tcgaaaattg ctgctatcaa atcgatttcg
     7681 acatttcgga cagtcggtta taggcgggtc gccgacgtag tccacgtgcg ccgacgagtg
     7741 cgagcgccac catcaacccg gagcgcaaca gcatcacgtc ggaattgtct gagccccagc
     7801 acattttgca atcggcgtcg atcatgttgc cgcctgtccc cggcaagcgc atgggtccag
     7861 ccgagcacca ggcccaggag tgtcatcgcc agcgtgatgg gaacgaagac caccaggacc
     7921 cgcaagaaat gccctcgaac aaggctggtg gattcgcgaa gatcgacgag tggtggaagc
     7981 gccggacacg acggacaccg atttattact catcggtctg gtgtcgagtg cgcatctgca
     8041 gtcccgagcc aaaaccaatc ttcagcgctt ccggcggccg aacaatacgc cgacagtcga
     8101 gatcatgatc agcgccacaa gaacgacgac gatgtacgac ctgtccgcgg ccggtgccac
     8161 cgtttcgctt tctttggtca ctgcatcagt gaatgtacag cttatgcctg gagggaacca
     8221 tccccagaag tctgtaattc ctgccgctac cctctccgcc cggccgggaa ggagataatt
     8281 gaatcgtgat gggattccat agtgatcaat gcaccagctg ggctgatgtt ggaggcgcaa
     8341 agaaaatgcg tccaacaaat agaccaaggt tagtgcgatc agcgatattg ctaaagacgc
     8401 ttggcttgct cgtaataatc gaatcttcac gactcgcccg caacagtcac gtcatcatgg
     8461 ggtgacgatg gtattggttg ctgcgatcca ccgaatccgg ccgtgctcaa aattgacctg
     8521 tcgactttgg gagtcgccga gctctcctga catcggtagt tcaaatcgac catcctcgca
     8581 gccctgcttc ccatagccag caaagatagc accgtggaca ctttctccgt gccgagaaac
     8641 aatcgatcgt gagatcgggg aagtggttac tgctagtccg cgacaaacag ctcgctattc
     8701 tcatcgaatg gatcaggcag tgtcgaactc gcaggcaacg agaaggtccg gtgctcttcg
     8761 ttgggttgtt ttggtaaacg cacttatcgc agcgtcggcg tcggcgatgt atgtcgcagc
     8821 gaaatgccat ctcacctggc ccgaacctgc ggatagtgca ctctcgatcg ccggtgcggt
     8881 cgttctctgg gtcctcacgg cgagtgttgc aatcgtgctg ctcggagtgt gctggtggca
     8941 gcgacgccga tggttgtggt ccgatgtcgc tgttccggtt ctcgtggtga tcgcactcgg
     9001 gatcgcggcc gcggggcagc cacatttcga tcagtatcgg gcagacttcg aaaccgttgc
     9061 acagcaacta cttcaagaac ctgacgatcc ctattccgat gggtatcatc gtgatctacg
     9121 aatcggcaga ttcgatatct cctatgccaa cgtcagcagt gaaggccacg tctatttcta
     9181 tgacgcacga gatggattgg acatcttgga caatcccggc tgggtgtatg cacccgatgg
     9241 tgtgtccgac aagaccttca atcagctccg gctggaagac atcgggggcg gatggtaccg
     9301 attccctcat cttgtcgttg acagctattg aaactcaaac caccagaccc tccgctcgaa
     9361 gtctcgggcg aatgtggtga cgccgaccag cattcctgag gcgaagggaa gtaggagtac
     9421 gaaaagcgtc gtgaaggtca aggcggtggc ggcgcggcaa ccgccacccc cgtcgtacca
     9481 gcgcgagcag atgtccccga agtcccaact ctcgccccaa cgctgaacga accagcccga
     9541 aagtgcggct gtcaggatca gtaggaatat cgtcgccagt gaccatgcga tctaccctcg
     9601 gcatcgccgc caggtcgcac acatcatcgg cgaatacagc tcggtgaagt gcggatgcgt
     9661 ctcatgatga aacaatattg ttcgtctgat gatccgcacg gattccgaaa gccgataccc
     9721 cggacttgct ccgaggtatc ggcctgaggt cagaggcaga agaaactgag cgaactgatt
     9781 gccgcgttct gctcgagttg gccggcatct ccgacgttgc cggcggcgac tgacagatct
     9841 tgaagggaga gaatagcgtc cattgtcatt tcctttgttg atcggcgttc ttgccgatgg
     9901 atttgatcga tcgagtttgc ttgcggtgtt gatttaattc caggtttttc gcctggtact
     9961 tctgtgctcc aatctgccgt gggtgataac ttccgaacaa ttaggcgatg tggcagttcg
    10021 acgcgcacat cagtggaaac gactgtcggg cagttgccga tcgggtatat cggagcaacg
    10081 ccagtattcc tgcagatccg gttgcccagt ctgtcgagag tctcaggttc tgttcacctg
    10141 gaaagtgcag gcctcctgcg tgattgaggc tgtgcaagcc cagaagctga aactgctgtg
    10201 caagcgtctg ttcacaatcg gcgccggcgt atggagtctt ggagagttcg ctgagaaaca
    10261 gaatcagccc ggctcgcccg ttgagtagtc cggcttgggc agtgaattcg actgtggcgg
    10321 cgcgggatat cgcacgcacc gcagctgcgt aacgcggttc gtcgacatgg cgcagaagtt
    10381 gtagaagtac caggcccaca ccgacagacc cggatccgag atacggcatc gtccggcgct
    10441 cctctctcag ctgcatcgac ccgtcagggc acatcgacat cacagacaga tcgatgtcga
    10501 cgagctggcg tgcgtgttcc agcgatcgag gatcaccact cagttcgtag tggcgagtcc
    10561 agaacagtgc ttgtccgctc ggtccccgca tcagcccacc tcggccggcc actgcccaag
    10621 gtgttccgcc ggcgtcgcgg acatgcaagc gagcagctga aattcgttcg cgcagagtct
    10681 cggtcacgac agcgagagtg ggtgacacag tcggtcgtga aaccgattcc tcgagtagga
    10741 ggcaaccgat tccggaaagg ccgctgaaaa ggctggagtc gatgtcgtcg agtggggctc
    10801 gacgcaaagt ctcgacccac ctgtcggctg tcgaatgtcg cccgtgatgc cgaaaggtat
    10861 gcaccgcacc cgcgagcccg tcgaagaagc cgaactttgg ttgagtatcc gaatcaactt
    10921 gatgttcagt ccattccaga actgactcca aggtgtctgc gggaagtaca tcggcgagca
    10981 ggtttccgca cgagccgtga gcaatgccgt agccgttcac ctcgaactgg gcgatgtcgc
    11041 cgggaaagag tcgatcagcg cgggcgagat caagcgaggc gaggatgccg cagcgcaata
    11101 gagcggccgt gcgttgcaag gtttcgttcg acgacgtgtc ccaacgatgc gggcgattct
    11161 tcggcgccgg cgcctgtacg tcgagcatcg aatagagcga ggcaccgaag gcgcggggaa
    11221 gatcgaatcg agacaccgca tagtcgatga gttcgggaat cttgttgcga tcgagaggga
    11281 acaatgtagt aagtgggaca aagagtccca gctcgatgca tcccaacgag tatcgatccg
    11341 ccgcgattcc tgtcaactgt cgaggtgctg tgtatccggg ggctccggtg gaccggggcg
    11401 gatgctcgtc gatgttgtgg gccatctcga agtcgatgat ccgaataccg gacggtgagc
    11461 acatgacgtt gccagggtga agatcggcat gaacgattcc ggcgttgtgg aagctctcga
    11521 ctgcggtagt caactgttgt gcaatgtcga gtgcccaggt tctgtattcc gttcgggaac
    11581 tgagtgtctg gtccgcacgt atcagtgggt gacggagcgc aacttcctga ttcaggggag
    11641 tgccggcagc gcgctcggtg acaaggaagt ggtgtccctc gcgctcgaac aagctgatcg
    11701 cagaaggtgt gtacgggttg tcggcaaggt gagtcaactt gtcgtactcg ttacggatgc
    11761 ggtcgattgc gtaccggccg tttgcgtccg gggcggtaaa gggacggcct tctttgatga
    11821 ccagatcgat gccggcgtcg tcgaatgcgg agtagatccc cccgctgttg ctgaagtgca
    11881 gggcttcatt gatcgaatag gggaattcgt catgtgattt cagcttgtct tgctgcgcgc
    11941 gaacgaagtc cgggatttgt acccagtccg gagttctgaa ggaagtgccg cgcacatcgg
    12001 gttcgagcga tccgtcagga cgccgaattg ccgggacgcg atcgccgaat gaatcgtagg
    12061 tctgcatggg cagatacgcg ccgtaccgta agtagagcgg tccccggttc catcgcacat
    12121 cgctgaggat gtacggcccg tcggcaccgg cgacaagctt gtccagttcg gtgatgacac
    12181 gttgtgtggc aacaccatcc gccggataga tcgtgatgaa ttttccgctg gaagttcgat
    12241 tggcctgctt gctgttggac aacatgaggt ctgctgccgt ccgaagaaat ttgaacggca
    12301 catgattgtg accgcaatac acggaaacgg tatcgagcaa ctcctgcgcg ttggctcggg
    12361 tagcggagca gtgaatcttc catccttgtt ctggcagcag accgtcgggc ggttggaagt
    12421 agttccacgg tccactttgg ggaccgcgcc gccagagcga ccaatccacc gacttcgcgg
    12481 ggataaagtg ctggtcagtt gatgtatctg gtcgggtgac cgttctgatt cggtcgtaga
    12541 aatgcgggtc ggcacgcgtg aaggcaacgt atcgcaggtc cacgccaaac ctcccagtca
    12601 gtccccctgc ggttgtcatc gattggtgcc acgccccgaa tcccctgtgg cttggattgc
    12661 ttgtggcgga aggttatccg attccggaca tttcgggcga agattgaaaa cctatcattc
    12721 gaaagtacta atgaatggcg tgggccaggc gaggtcactg atcgcccagc ttttagtcgg
    12781 ccacatttgt ttcgagttcg gaggccccct cttgacgaga ggatcaagtc ggtggtagtt
    12841 ctttagcgag cgctaagtca gggtgctccc tcgatctcgg tccggtaccc ggcgccacga
    12901 aactcgggtg ccggaccgcc ccagcaatgc acgtcctcga agggaacgaa gatgaccaag
    12961 gcagtgatcg tcgatgtagt ccggatcgcg tccggcaagg gaaagccggg cggcgcactg
    13021 tccgggacgc accctgtcga actgatggcc cacgttctgc gttccatcac ctcgcgaaac
    13081 ggcctcgacc ccgccctggt ggacgacgtg atcggcggtt gcgtcggaca ggccggtgag
    13141 caggcactca acatcacccg cagcgcggtc ctctcggccg gattccccga gtcggtaccc
    13201 gccaccacga tcgatcgcca gtgcggatca agtcagcaag ctgcgcactt tgcggcgcag
    13261 ggcgtgatcg ccggggccta cgacatcgtg atcgcggcag gcgtcgaatc catgagtcgt
    13321 gtcccgatgg gtaccacgac gatggggaag gacgcttccg gtccgggcgt cgctgctcgc
    13381 taccccgaag gcctggtcaa ccagggcatc tccgcagaat tgatcgccgc caagtggaag
    13441 cttgaccgcg acgctctcga cgcattctcc gcgcagtccc accagcgggc agcagaggca
    13501 gcggcgaagg ggctcttcga caaggagatt ctgccgatct cggtgaccaa cgccgccggt
    13561 gagaccgtct cgcataccgt cgacgagacg gttcgcgcgt ctactaccgc cgagggactc
    13621 gccggcttga agccgtcgtt ctactcggag aagtacgcgc agcgcttccc cgaggcgcag
    13681 tggtcgatca ctcccggtaa ctcgtcgccg ctcaccgacg gcgcgtccgc agcactgatc
    13741 atgagcgaag aaatggcgtc gaagctaggg ctgacgccgc gagctcgttt ccactccttc
    13801 tccgttgcgg gcgatgaccc gatcttcatg ctcaccgcac ccatcccagc cacccacaag
    13861 gtgctcgctc gcgcgggtct gagcatcgac gacatcgaca cctacgaggt caacgaagcc
    13921 ttcgctcccg ttccactcgc ctgggctcac gagttcggcg ccgacccggc aaagctcaac
    13981 ccgtggggcg gcgcgattgc actcggccat gccctggggt cctcgggtac tcgtctgctg
    14041 accacgatgg tcaaccacct cgaggccacc ggcggacgct acggattgca gaccatgtgc
    14101 gagggcgccg gcatggccaa cgccacaatc atcgaacgca tctgaaacac ataacctttc
    14161 gaaaggaact ctcatgatcg tcaacgacag cgtcgccgtc gtcaccggtg gagcatccgg
    14221 cctcggcctg gctacgacca aagcccttct tgccgacggt gccagcgtcg tcattatcga
    14281 ccttccgtcg tccaacggtg aagccatcgc caaggaactt ggcgaccggg tccgcttcgc
    14341 ggcggcagac gtcaccgacg aggctgcggt caccgcggca ctcgacgtgg ccgagtccct
    14401 cggacccctg cgcgtggcag tcaactgcgc cggaatcggc aacgcagtca agacggtcag
    14461 caagaagggc gctttcccgc tcgacgcgtt caagaaggtc atcgacgtca atctgatcgg
    14521 caccttcaac gtccttcgtc ttgctgcgga acgtatttcg aagaccgagc cgatcgacgg
    14581 tgaacgcggt gtcatcatca acaccgcttc ggtcgcagcg tatgacggcc agatcgggca
    14641 ggctgcgtac tccgcgtcga agggcggcgt cgtcggtatg acgcttccca tcgcccgtga
    14701 cctcgcgtcg ctgctgatcc gcgtcaacac cattgcacca ggcttgttca agaccccgtt
    14761 gctggccgga ctgcccgaag cagcccaggc gtcgttgggt cagcaggtgc ctcacccctc
    14821 tcgcctgggt gatcccagcg agtacggcgc gcttgctgcg cacatcgttt ccaaccccat
    14881 gctcaatggt gagacgatcc gcctcgacgg tgcaatccgt atggcaccgc ggtaatttcg
    14941 gctatcacat gactggcgag gtggagtcgg tgagctcggt ggcagtggac tggaggtcct
    15001 tcccgccgct ggtgatgacc gacatcctga tggcttcgct cgagctgttc gacgagaatg
    15061 gttaccacgg cacgacggtg cgccagattg ccaatcatgt cggggtaacc gttcccgcgc
    15121 tctactatca ccacgcgaac aaagaggcaa ttctcgtcgc tttgttcgag gtctcgatga
    15181 gtgagctgaa taccagaacc gaagcggcag aagcggaggc cggcgaaaat ccggtacgac
    15241 gcttcgcctt ggtggtggag gcgatagttc tctatatgac ccaccggtcg cggcatgctg
    15301 cgttggacac cgagattcgg catgtctcac cggaaagccg aagtcgatac gccgccagtc
    15361 gtaagcggct cgagttgctg atgcgcagga tcgtcgacga cggtgtggca tcgggagatt
    15421 tcgcggtcac cgataccgaa gagaccgtcc gggcaatact cggtatggcg cagtcactgc
    15481 cgcgttggtt ccagaccggc ggtccgatgt caccgtcgca attggcggag aagtacgtcg
    15541 atatcgcttt tcacacggtc ggctatcggc cgtaaagtgc atcgctcgtg aacgaaggtg
    15601 ggcaacaggt gaaaacctgt tgcccacctt cagtattcat acttcggcat tcactcggtg
    15661 tcagagtcgc gtaacttcga gtccgccctc gtggtagtcg gcgcgaaggc gtttcttgtc
    15721 gaacttgccg acgctcgtct tcgggacttc ctggaccacg gcccagttct cgggcagctg
    15781 ccacttggca accttgtccg aaaggtactg ttgcagttcg gacatggtgg tttcggaacc
    15841 agcgcgaaga acaaccgcaa ccaacgggcg ctcgtcccac ttctcgtccg gcacgccgat
    15901 gacggcagct tcggtgacgt cagggtgacc catgacggcg ttctcgaggt cgaccgagga
    15961 gatccattcg ccgccggact tgatgatgtc cttggagcgg tcggacaggc tcaggaagcc
    16021 gtcggccgtg atggatccga cgtcaccggt cttgagccag ccgtcgttga acttgtcttc
    16081 cgcatcgacg ccgtagtacg acccggtgat ccaggggccg cgcacttcga gctcgccgac
    16141 ggaaacgccg tcgtgtgcaa caactttgcc gtcatcgtcg atgagacgtg cctcgacgga
    16201 tgccgggaag cggccctgag agtagcggta cttccacatc gcgtcgccgg tgacaccggc
    16261 cggcgggcgg gcgacggatc cgagtgggga ggtttcggtc atgccccagg cgtgcaggac
    16321 ggagacgttg tggtcggctt cgaatgcgtg catgagggcg ggcggtaccg cggacccacc
    16381 gatcagaacc tcgcgcatcg aggagatgtc ctgcgggttc tgctcgaggt agaggtgcag
    16441 gccctgccag atggtgggga cggctgcggc gaacgtcggc ttctcgctgg cgatgatcgc
    16501 agccaacggg gcaggctgga ggaagcggtc gggcatgatc agcgaagcac cgatcatgaa
    16561 tgcggcgtag ggaagtcccc acgacatggc gtggaactga ggcaccacgg cgagtgcacg
    16621 atcgccctgc gcgaggttgg ggccgtcgct catgcagacc tgcatggagt gcaggtagat
    16681 cgaacggtgg gagtagacga cgcccttggg gtcacccgtg gtgccggacg tgtaacacat
    16741 tgcggcagcg ctcagttcgt cgacctcggg ccagtcgaac tcggtgggct gatcggcgat
    16801 caagccctcg taggtgtgaa cctgcactcc ctcgggagct tcgagtcctg cagtggagga
    16861 gccggtgacg acgatgtgtt tgacggtggt cagcgacgga agctgcggag agagaagcgg
    16921 aatcagggac gggtcgacga tgatcacgcg gtcctcggcg tgattggcga catggatcaa
    16981 ctgctcgggg aacagacgaa tgttcagggt gtggagcaca gcgcccatcg aggggatcgc
    17041 caggtacgcc tcgaggtgct cggagttgtt ccacatgaac gtggcgactc gctcgtcgcc
    17101 ctcgacgccg agcccgcgca gggcgtgcgc gagctgagca cagcgcttgc cgacgtcagc
    17161 gtaggacaca cggcgcgggc cggactcggt ccacgtgaca acctcggagg cgccgtgaac
    17221 ggaggcaccg tggcggagaa gttgagcaat ggagaggggg gcgtcttgca tggtgctcag
    17281 catgggctgc tcctgtgtgg tgtgtgagac cggtgctttt gcccacgggt cgtcacaaac
    17341 gatgtgctgt ggctgccaga ttagtcacag ccccgaagtg ctcgctagtg acccactgca
    17401 ctggcgaaga accacgctat gagtagcgct cccggatcga ctactccgcg agcggcttcg
    17461 cccacataac ttgcacgtcc gcggttcgcg agcatggttt cggtcgactc cgccccggcc
    17521 gctgcggctt ccgctgcgct cgccagcgca gcatctcgat cggcttccga gctcacggat
    17581 tgctccaacg actcgaccgc cggaactatc gcgtcgacca tcgtcttgtc gccgacgcgt
    17641 gcgccgccga gcgaggtgat gttgtcgagt cccgctcgcg ctgcagccgc gatcgcgccg
    17701 aggtcgagtt cggagtccgc cgagtctgcg gcaacgcgga agaaatgccg gaaccagatg
    17761 ccgaacaatg cgccggaggt gccaccggcg tggccgaggt acgcctgtga gactgcatcg
    17821 aatatcgttg cggtggagta cgtgtcacgg atcgccgaga tgtcgagttg atccagtgcg
    17881 gccaccatgt ttgtcccgaa atcgccgtcg cccgctcgtc ggtcgagatc ggtcagtgcc
    17941 ggttcctgat ccagtacctt ctcggcccag tccgcaatcc agcttccgac gaagctgctt
    18001 tcggcggtgc gtgaggtgtc gggtgtgaat gtgggaccga aagattcgcg cgtgcccatg
    18061 ccggtgtact cacgcgctat agcattcggc caggcgggcg cttttgttgg tgcgtcccat
    18121 aattcgagga tttctttgtc tgtgcgaaca agggtgatgg acgcgcctgc catgttcaat
    18181 gcagtgacga aggttccgat cagggtccgt tcgatgtgaa ttccctgttc gtccagataa
    18241 tctccgagtt cggcgaacag aagttgcaac tccagcgggt gggtggcgcc gagaccgttg
    18301 acgacggcga tgacgcggtc gccttcggcg agactcaggg acttgatgat cgggtccgtc
    18361 agccgccgca ccaattccgg tgcgggcagg gcgtccacgc gttctgtgcc gcgttcgccg
    18421 tggatgccga taccgagttc catctgaccc gccggcaagt cgaacgacgg ctcgtcagcc
    18481 cccggcaaag tgcatgggcg aagggcgacg gccatgctcc gagcggagtg cgcgacgtgt
    18541 tgtccgatcc gggtcacctc ggccaggtcg tcgccgcggg cggcggatgc gccgcagacc
    18601 ttctccacca cgatggttgc cgcagtaccg cgtcgtcccg gaccgctgcc gtctgcgcgt
    18661 tcggtcgcga cgtcgtcgtc gaccaggacg acgtccgtat cgatcttgtc ctcgcgtagc
    18721 aactctcggg cgataccgaa gttcatcacg tcgccggtgt agttcttcac gatgtgaagg
    18781 acgccgccgc cggcgtcggc agccttggat ccctcgtgga tctgaagtgc attgggtgag
    18841 ctgaagacca atccggggca gacggctgtg agcattcctt cgccgatgaa tccggcgtgc
    18901 atgggttcgt ggcctgaacc gccgccggag acgagcgcga cccgtccgcg gggaagtggc
    18961 cttgcgcgtg tgaggtaccc agggtcggga ttccacgcga tgtcgtcggt ggatgcgatc
    19021 aacccacgga gtgcgtcggg aacaaatgtc tttgcgctgc gcatgaacat cacttcagag
    19081 taggtctaac gtcgacttcg ggcacggatc acgatcgacg agaggtggac ggcgtgaaat
    19141 tggggttggt acttgccggt ggcggcgttg cgggaatcgc ctgggaaaca ggttttctgt
    19201 tgggccttca ggacaaatca ccggacactg ccgctgcgct gctgacggcg gacgtgttga
    19261 tcggcacttc cgcaggttcc acggtgagcg ctcagatagc gagcggcgtg acactgcaag
    19321 aacttttcga cgcacaaaca gcggaggcta ccggcgaaat cgacccgaag gtcgatgtcg
    19381 aggtactcgg tcagatgttc gtcgacgcga tcgcaggatc gcaggaccgg gccgagcagc
    19441 tccgtttgct cggcgaagca gcgatgagag ccgataccgt cgaacctgcc gtgcgtcgcg
    19501 cggtcatcga ggcgaggctg cccaatcggt tgtggcccga ccgggagttg cgcatcccgg
    19561 cgatcaacgc acagaccggt gagttgaggg tgttcggcaa cgctgacggc gtagaactga
    19621 tcgacgcagt cggagcaagt tgcgccgtac caggggtgtg gccggtagtc gtgatcgagg
    19681 gcgagcggta catggacggc ggaatggcga gtggctcgaa tgttcatctg gctgccgact
    19741 gcgatgtggt cgtggttctt tcacccgcag ccgaccccgc cccgaatctt ctgggcggca
    19801 gtctacgaga ggaaatcgac gtgatgacgc ccttgcccgt gctgcctgtc ttcgccgacg
    19861 acgccgtcgt cgaagcgatc ggaacgaact cgctttcacc gacaaccagg cgccccgcag
    19921 ccgaactcgg ccgcgaacag ggccgtcgaa ccgccgacga gatcgccgcg tttctggtga
    19981 cggcatgagc gccgcacgga ttgccgtcgt cgtgcgcccg gagcaatctc cggaagatct
    20041 ggttcgacat gccaggtatg cagacgaagt cggtatcgac gaggtctggt tgtgggaaga
    20101 ctgcttcttc ggcggaggaa tagccactgc tgcaactgta ttggctgaga ccgatcgcgt
    20161 gggtgtggcg atcggtgtgc tgccgacgcc gatgcgcaac accgcgatca cggcgatgga
    20221 gatttcagcg ctggccagag ttcatccgga tcgactacgg gttggcttcg gtcacggcgt
    20281 tcagagttgg atgcggcaga tcggggccaa agccgaatcg ccgttgaccc tcctgcggga
    20341 gcagttcgga gcagtcgagc ggctgctggg cggtgagtcg gtgacggtgt ccggtcgata
    20401 cgtgaatctc acggacgtca cgctggcgtg gccaccggag acggtgccgc agttgctcgt
    20461 cggcgccacg gggccaaaga ctttggcgct cagtggcgag ttggcgcagg gcaccgtgct
    20521 ctcgggtggg acgaccccgg acggcgtgcg tcgggcgatc gctcacatcg gggcgtcgga
    20581 tcacgaggtc gtcgtctacg tcatctgtgc tttcggttcc ggcggtcgtg agcgcgccct
    20641 tgccgaggcc gcagcgtccg gtagcgagtc gccggaggat gcgattgccg tgggcaacgc
    20701 ggccgaagtc gcggcagcag cacggcgatg ggttgcagca ggtgcaacca ccgtggtact
    20761 ccaaccgact gttgacgagc cggatgtccg cgagttcatt cgctttgtcg cgcaggaggt
    20821 tcaacccctg gtggcgtagt tcagaaggtt actctggaca gaaccgcgtc gatgtcggca
    20881 gtgctcacgt cgcgatgtgt cacgaaccga accttcccgg caacggtgac cgcgccgaca
    20941 tcgacagcgg cgagctgagc aacggtgacc gacggatcgg ctgtcgcggc cagaacgatg
    21001 ttggtggcag gttcgtcgac ggcccaaccg cgttcacgaa gccccgacgc gaggcgctgc
    21061 gcgttgtcgt gatcgtcgga gaggcgagct tgtgagcgca acgcgacgat gccggctgcg
    21121 gccagcactc cgccctgacg aacgccgccg ccgagcatct tgcggatcct tcgggcttcg
    21181 gtgatcaatt cgggtgatgc ggcgagtatc gagccgaccg gcgcaccgag tcccttactc
    21241 aggcacacct gaacggtatc ggcgccggaa gtcaattcgg tgggcgaaac atcgagtgca
    21301 acagcggcat tccagagacg ggcgccgtcg aggtgaatct tcaagccgcg tgatcgcgct
    21361 gcgttgacca gcttcgtcca ttcggtcgga ttcatgacgg caccgccggc gaagttatga
    21421 gtgttctcga gacagagcag cgtggtgttc aacgcgaagt acgggccggg ggagcccgcc
    21481 gccttcacga ccgtctcggg ggtgggacgt ccgggtccgc cgtcgtgcgg caacgccatc
    21541 ggcattccct gggcgagcca ggccgcggtg cccaattcgg agcccaagac gtgagagtgt
    21601 tccggtgcca ggaactgatc gccgcggtga aggtgcagca tcagcgcaat caggttgccc
    21661 atcgatccgc tcggcaccca cagtgccgcc ggtaaaccca gagtgtgcgc cacctcttcc
    21721 tcgagcgccg ccatggtcgg gtcgtgatcg aggacgtcgt caccgacctc ggcgtcggcc
    21781 atcgccttcc gcatctccgc atcaggcttg gtgacggtgt ccgagcgtag gtcgatgtac
    21841 gacgaagtca tggctcattc gatcaagccg cgtgttccgg cgtcaaaccg cggtatttcc
    21901 aggacggctc ttccggcctg ataaatcgat atcgctgagg atgccttccg tgtgatgatg
    21961 agcgccggca atcgccggtg acgagaacaa gaagtggaag gggacaggca tgcgcgactg
    22021 gaagcaagcg ttgcacctgc gcgggcactc accccgcggt atttcccatc ccgcattcgg
    22081 ggaacagagt ggcgctggat atatgccgtt ccccatttct tgcatttgct cctgacccgt
    22141 cttcgtgtcc aggagtttca ctcctcgaca cgaactgaga actctcatgc ggaacccgaa
    22201 ccgcgcactt gctcacagtt ggatgaaccg ccccgtccgg gtactcaacg ccacgtacga
    22261 gtacctcggt gaagtgagcg ccgatcgtgc ggtcgtcctg atcgccaccg gctccgcgca
    22321 gtccaccgaa gacgtgaccc cgatatttcc ggtgcgctcc aagcacgtcg aaatcccact
    22381 gccgaggacg atcctgctcg ccgagtacgt gtacgttgct caccgggtga cggtcaccga
    22441 ttccagtcgg gccacttttg ccggtgtctt cgaccgggac ggtcgtcaat gtgcgtactg
    22501 cgccgcccgg gcaacgacca tcgaccatgt ccagccgcgg agccgtaacg ggcccaacac
    22561 gtggggaaat ctggtggcgt gct
//
