LOCUS       NZ_JAPTYM010000001     25184 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10034062
            Orig. end                         :: 10059246
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25184
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aureonuclemycin"
                     /region_number="46"
                     /rules="(her4 and her5 and her6 and her7)"
                     /tool="antismash"
     cand_cluster    1..25184
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(her4 and her5 and her6 and her7)"
                     /kind="single"
                     /product="aureonuclemycin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25184
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15184](+)"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15184
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
     misc_feature    3..17
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            646..5508
                     /locus_tag="O1M07_RS44460"
                     /old_locus_tag="O1M07_44445"
     CDS             646..5508
                     /NRPS_PKS="Domain: PKS_KR (1009-1237). E-value: 8.4e-28.
                     Score: 89.5. Matches aSDomain:
                     nrpspksdomains_O1M07_RS44460_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_DH (1313-1474). E-value: 2.3e-08.
                     Score: 26.5. Matches aSDomain:
                     nrpspksdomains_O1M07_RS44460_PKS_DH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020243.5"
                     /locus_tag="O1M07_RS44460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44445"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_189868030.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.2e-16, bitscore:
                     59.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 1.4e-45, bitscore: 155.1,
                     seeds: 2284, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRARTTREPGPVLPGLARDQYVAIVGMGLVVPGADTPERFWTL
                     LQSDDVALIGPTRFRSRPLTASREPGERSSGARAGFVRAFEPHPVLAANLAAGDLDDVP
                     DETLWLRHSALHALTGVTVRPDDRVTHAFGAWTHSTQAMEDTLVVEEIAERVAREGADE
                     PFEQIAACHRQRRRLGEHFRHARQRPADALPGAVLARALEGLTPEPREVLLVDAASASS
                     LYALQLAWEQLRSGESDIALVGGFNNVGRLGMAQLTAFRGMAASGCLRAYDPAADGTLF
                     AEAAAVLALKPLGRAIADHDPIRAVVGAVATAGDGRGAHIAVPNPRGQSRAVSDAMTTA
                     SVTTDDVAWVIGHGGGSPVGDRIERAVLTELWRDTPLVCASNKPHIGHPSWAAGAVSLI
                     HAVLGLHHRPSAGHLPPSSRPLTAAGVTAIGLGGANAHAIVHDRHHARPPVAQRPRDDT
                     NPVVVGWSAVLPGRPDRHQIGHLLRTRTAQRTYSAADLDLPFDVTRLPPALQPSLDPHQ
                     LLALDAAHALVAVQGELWSRHRDTTAVVVATPLPSPRLSAVTLRSAIPELSELPWEGQD
                     AVAWARVRAGIRERTPVSEETMPGIVPGVAAGRVANRWDLRGPSMALTGPTAGHAALTA
                     ATTLLAAGRLDIALVLGSTLGAGPLHAAFAETHPGSLREGTFLLAVTTAGLASRAGWPV
                     LGTLDTDAEPPAWTTTRTDRPTGYFGIDPIAETVARLAASSLACAPSTARRRTEDDMPD
                     AAPRPADSPPPQPDSRQHSDPVSAHTTRTALVLRRSALPPANHGAERVGALPPGCLVLT
                     NSHALAATLTRRCRARRALLVSTDTADGPPAEGVHQLAGAGGAEGLKEQLISLRPHVRV
                     IADVRAAAAPWPGPVPAALAHLHDALLTALKAFGARMADGSLAVIVHDTLTAGLVRPHG
                     ALLTGMVRSLAWELPRRHTLALVTDAPPDQALKQLATELAADRDRPVVHYSNGTRLTEH
                     LVASPLPADRDLTSPFAPGSVIVAAGGARGITATILCDLAARHRPAIWLLGTTSIDGLG
                     EDLALAAAEDEGTLRRKHIAQAVSAHPPRSVAEANREFTALWQAREVVANLRRLRALCG
                     SDRVRYLRCDITDARATARAAHTILANHPRIDLLIHAATRSRPALLAAKTIQDVHQVLD
                     TKVGGYLNLRAAFAQSPPALWCNFGSDVPLFGIPGDLDYVAANAFLSAAARYNSALGTR
                     QEITIGWGLWTESGFAAGELERERTRRLGLATGLTDAEGTAAFRREIATPPSLEANPLW
                     TSSSERALAERHSPGITSALDPAPPTPRTLLGAPDHRGTDHAQWTWTLDPHRDTYLLDH
                     TLDQRPLLAGTLFLALAAEAADTLMPDTPATATAMENAQFDQYAWADPTRPGPTKYRIA
                     ARRSGPTRIHVAMRSDITTPDGKTLLKDRRHAAVDIVLTTPAPHTIANPTEPAPAAQPP
                     DTVRPPASRRRTDPTWEPQSPLRLYGPFHNLHALEQSPTRVRARWHAHLSPHDTTAQLR
                     LPALLLDAMVRTTFFTAGEPQHAHIRVLRGIARIDLPAHRSDRDLALLHPEGIELTCDI
                     PTNDCTATTRSGRLVASLTGVDTPAVARIPTLPVRNPRTPR"
     misc_feature    3055..3057
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        3673..4356
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1M07_RS44460_PKS_KR.1"
                     /evalue="8.40E-28"
                     /label="O1M07_RS44460_PKS_KR.1"
                     /locus_tag="O1M07_RS44460"
                     /protein_end="1237"
                     /protein_start="1009"
                     /score="89.5"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="VIVAAGGARGITATILCDLAARHRPAIWLLGTTSIDGLGEDLALA
                     AAEDEGTLRRKHIAQAVSAHPPRSVAEANREFTALWQAREVVANLRRLRALCGSDRVRY
                     LRCDITDARATARAAHTILANHPRIDLLIHAATRSRPALLAAKTIQDVHQVLDTKVGGY
                     LNLRAAFAQSPPALWCNFGSDVPLFGIPGDLDYVAANAFLSAAARYNSALGTRQEITIG
                     WGLWTE"
     aSModule        3673..5067
                     /domains="nrpspksdomains_O1M07_RS44460_PKS_KR.1"
                     /domains="nrpspksdomains_O1M07_RS44460_PKS_DH.1"
                     /incomplete
                     /locus_tags="O1M07_RS44460"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       4231..4299
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O1M07_RS44460_0001"
                     /evalue="3.90E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="O1M07_RS44460"
                     /protein_end="1218"
                     /protein_start="1195"
                     /score="16.2"
                     /tool="antismash"
                     /translation="LFGIPGDLDYVAANAFLSAAARY"
     aSDomain        4585..5067
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1M07_RS44460_PKS_DH.1"
                     /evalue="2.30E-08"
                     /label="O1M07_RS44460_PKS_DH.1"
                     /locus_tag="O1M07_RS44460"
                     /protein_end="1474"
                     /protein_start="1313"
                     /score="26.5"
                     /tool="antismash"
                     /translation="LLGAPDHRGTDHAQWTWTLDPHRDTYLLDHTLDQRPLLAGTLFLA
                     LAAEAADTLMPDTPATATAMENAQFDQYAWADPTRPGPTKYRIAARRSGPTRIHVAMRS
                     DITTPDGKTLLKDRRHAAVDIVLTTPAPHTIANPTEPAPAAQPPDTVRPPASRRRTD"
     CDS_motif       4660..4737
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O1M07_RS44460_0002"
                     /evalue="2.10E-03"
                     /label="PKSI-DH_m2"
                     /locus_tag="O1M07_RS44460"
                     /protein_end="1364"
                     /protein_start="1338"
                     /score="10.8"
                     /tool="antismash"
                     /translation="YLLDHTLDQRPLLAGTLFLALAAEAA"
     gene            5505..5954
                     /locus_tag="O1M07_RS44465"
                     /old_locus_tag="O1M07_44450"
     CDS             5505..5954
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024675.5"
                     /locus_tag="O1M07_RS44465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44450"
                     /product="thioesterase family protein"
                     /protein_id="WP_189868031.1"
                     /sec_met_domain="4HBT_2 (E-value: 1.7e-13, bitscore: 50.0,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSYDIELVATTGDTNMVGNVYFATFLRWQGMCRELCLAEHAPK
                     YLQELDGEITALTESASCTYRDELWVGDRVSIRMTIPWIRLHLMPLRFEYYRLTDDGEQ
                     LVATGEQMIACMRKHGRSFSPGPWPPEMLALGSHLGADIHRAFTE"
     gene            6214..6510
                     /locus_tag="O1M07_RS44470"
                     /old_locus_tag="O1M07_44455"
     CDS             6214..6510
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS44470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_44455"
                     /product="hypothetical protein"
                     /protein_id="WP_189868032.1"
                     /transl_table=11
                     /translation="MSPQRRLRLREAPLARTGAELGEVLDFVREEIAPFPTGNGHPAFF
                     AWVNSPPAPAGINAELLASAINATCGMGENALRRRALSRVPSLTSSAFEERSP"
     gene            7010..9772
                     /locus_tag="O1M07_RS44475"
                     /old_locus_tag="O1M07_44460"
     CDS             7010..9772
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.5"
                     /locus_tag="O1M07_RS44475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44460"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_189868033.1"
                     /transl_table=11
                     /translation="MGSVLLEREEALAAAARAGQSARSGAGRWLVFGAAAGTGRTALLR
                     EVAGREAAGGAMRVLRADCSPEESGFPFALVRQLFPEDGEVPFADLPAAEEQMVFHRLV
                     TRLARTADRRPVLLAVDDLHDADMASRRWLGYLARRLAALPVLLVLTECREKGTAVLPS
                     ATGTSVVLRPLGPEAVARLVSAHGHGADRAELCVRACAGNPVLVHALLADLREGPLPRS
                     LSELGGSRYRDAIVHWIRARATPWSRRLSLALAVAGGGAALLGGALLHEAAGLRPDHRA
                     ASAGASALRRLFSHPLAREAALAAVDPAELGALRGRIARLLDERGAPTADVAAQLLHLD
                     RPGEEWMTQSLEDAAEDAVRGGRVDEATAFLRHALTAPLAPGRRAGLTLRLGALELPHS
                     ADAGIRRLRAALELHADRHERAAVAPALGAALVARGRTDTAMRVMRQVGSAVDDGELVR
                     VLQTTAAVMASHDAVAWRNAVARMRELAATAPAAVEPLACGLVTEYEVGTGRLSAAEAL
                     GRVLPRLAAPVDPRLRDGWLGTAATLLQWADRLDEARALAEEALPAPPALPDLTDIGRQ
                     CLISVRAEAALWAGDFRRVIAENAPLLDACAGQGIRMPHLASMVALAHCELGHRAHARR
                     LLAGLDEESADSSWEWNELHYARAFLHMAEGNWQAALDDYLSCGRGQSARDFVSPVATP
                     WRSGAALALVGLGQPARALDLAEEELRHARTWGTPRTVSRALRAHAAAVGGRRGLESLG
                     EAAAVLRTAPAPVELVETLLDLGHARIDAGNSRKGREDLHEAHALALRLLAPDPTGHPD
                     APDAPATGRLLRATGNALRASGARGTRRDTTGSAALTRAERRIVELAAQGQTNAQIGEV
                     LHLARRTVETHLTHAYRKLGVTRRTQLASRLTGTGTAASSSARSLTTSG"
     misc_feature    7328..7330
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9824..9838)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.13"
                     /tool="antismash"
     gene            10001..11629
                     /locus_tag="O1M07_RS44480"
                     /old_locus_tag="O1M07_44465"
     CDS             10001..11629
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941311.1"
                     /locus_tag="O1M07_RS44480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44465"
                     /product="hypothetical protein"
                     /protein_id="WP_272492967.1"
                     /sec_met_domain="her4 (E-value: 4.3e-287, bitscore: 952.2,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDPHPPGPCEVLEGPLGVGDLLAAVRAVLDGHGGAPARPELTVH
                     GPGQYTVRVGGDRLDIRSRPLSDQPPGTLDPVLDGPGARRIVLTASGAPSEPARDLFTA
                     LTEAISRRARCYTEAEAAAIAAGMPLTGRYAQPEPALAGWALIFRDHYVENSVGFLLAM
                     ERAGLDPEWIFALSKGDRTQHRERVHSWFLRRGYASDTLDNSVINGTAGAAEAARARAV
                     DAQVANFVRRAHAAGRKVLVVDDGGLLAQGYGADGPGPRVDAAIELTVSGLKRITAAPG
                     ELAVPVLNMARSQLKSRLGYNEIADSCVRRLRAIVPGQKFIGRHVLLLGYGTLGARAAR
                     SLRALGCRVAVVDTDILALITAAEDGFETHRSIAEALDRQRPFLILGSSGGTAVTAEDV
                     PLLPDGVLLAGFATKDFSVLTDGYPGATAQRIPHVGVRYDLPHATTATVLGDGRSLNLF
                     EYEGIANRGYDAYRAGTLLAVLALCRDPERFPPGLHLEPVDRIIDDAGLFDAYYTQYLC
                     ARSAPLGTGAFSGTAETSGEDAHAR"
     gene            11619..12740
                     /locus_tag="O1M07_RS44485"
                     /old_locus_tag="O1M07_44470"
     CDS             11619..12740
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her5"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941309.1"
                     /locus_tag="O1M07_RS44485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44470"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_229922362.1"
                     /sec_met_domain="her5 (E-value: 3.1e-183, bitscore: 607.9,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGRPHVCVVGHGVAGRLHHQLLDGMGMSVSVVDPTAPGCGAPFP
                     TAATVGELSTDRPVDVWSVCTPTAGHVQAVAAVLARDPEARILLEKPACRSWEGPELTA
                     LLGAYDRARLVVMNQYAHAKAPAILEAVRAEFAPRHPVAAIRVAFCKDRREDIAAGRFV
                     DLDYGVFGYEWLHMLAVLGGFLPARAFHHYLLAGPEPQAVRIARDPHLVSTAAHDTTTL
                     SAGAGPAGEVEVELYSTIIGPDAPHAAPAPSWARRTAPAADSRLRLARIEAGPVLLTLE
                     LDPVFLPNGTRLPRNTHRLTMDGPHGHREWLIPDSPMDNALRHGIAALLGPGPRPALDL
                     RPLDRIGRLAELARAERPAPSGPPTPAALTTRL"
     gene            12754..14061
                     /locus_tag="O1M07_RS44490"
                     /old_locus_tag="O1M07_44475"
     CDS             12754..14061
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her6"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941308.1"
                     /locus_tag="O1M07_RS44490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44475"
                     /product="radical SAM protein"
                     /protein_id="WP_268934627.1"
                     /sec_met_domain="her6 (E-value: 3.1e-249, bitscore: 825.9,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRICLVIPSNKFDQYFIQLPLDAVTAAGQLRAEGHTVAVWDQRL
                     QEAPDGEEFDLLVVFSAIADRAQCYPLELGCVRVAVERAVSRYPAARTVAVGPHGTHLP
                     VSTRAELGVDHIACGEADSATVGAVRALLAGADASVLPGAAAPHNLLESPESRPRPFPN
                     LRLEELAFPAYDLVPTADYTAEVISGGLPLPGPCGMVLAARGCTYGCTFCHLPFGTKMR
                     NQPLDRVVCEIEAQQAAGLEFVFFLDYVFGINRVFYSELCARLEGRGVGWVGQTRAEVV
                     LKSDVAAWARAGCQGMWLGAESPAIADTGVHKRVSEAQIEEAVLKLRDAGITPFAFVLL
                     GLPQDQACVSGRLVDWAAKLPAWFGINQLYLRPGTALYDELAPRYNGGVLPATWREVQE
                     VTRRYRAAYPIDLDQQQQRLIELPNYLGNAIAPVAG"
     gene            14072..15184
                     /locus_tag="O1M07_RS44495"
                     /old_locus_tag="O1M07_44480"
     CDS             14072..15184
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576688.1"
                     /locus_tag="O1M07_RS44495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44480"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_189868189.1"
                     /sec_met_domain="her7 (E-value: 6.9e-207, bitscore: 685.8,
                     seeds: 189, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2.1e-22, bitscore:
                     79.0, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 8.2e-29,
                     bitscore: 99.1, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRFGILGCGSIGGFLGRLLARPDGPLRERACLVAVAGRDPVRAR
                     RLAAELGCVALAVPELLARMDIDAVAVCTPSGTHAELGSAALRAGKHVLVEKPVDVTPE
                     AADRLVAVARHTGRTLGVISQHRFDPAAEVARAAIEDGTLGRITSVLIEVPLWRARSYY
                     ASGQWRGTRALDGGGALMNQAVHAVDLAQWLAGPVVEAAAHTGLLAHDGIEVEDVATAS
                     LKFADGALGALLATTAAYPGRTTRVAVNGERGSVVIDNDELAYFHTAREGERPAAYGAY
                     GDGNQAADRCPPPREPPPRDRVGLLHQPHRDQLADFCDAVRTGRPPLVDGAAGRRAVAV
                     VHAVYTSARTGRTVRLDESGNLTQDKGRTP"
     gene            15181..16041
                     /locus_tag="O1M07_RS44500"
                     /old_locus_tag="O1M07_44485"
     CDS             15181..16041
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576689.1"
                     /locus_tag="O1M07_RS44500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44485"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_189868190.1"
                     /sec_met_domain="PCMT (E-value: 2.1e-09, bitscore: 36.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTLRHPAPDEHKQALARLFDRSAPTYEKVGVSHFGALGRQLVE
                     EARVREGERVLDVGCGTGAVLVPAARAVGPSGSVTGIDLSAGMVERSRAAIAEEGLSNA
                     RALVADAETAHWQPGPPVDGTFDAVLAGISMFFFPHPRAAAARYRRLLAGGGRFAISWW
                     GRQDERWNPVFAASAPYGGASSHRLAPDSPFRSVEDLHAMLSEEGFSSVDTVERACVTR
                     FRGPHQWWRWVWSTAGRQFWESVPEDAMADAVKAVEAELAALRAPDGSLTSRSIVRFTV
                     AEVAR"
     gene            16038..17660
                     /locus_tag="O1M07_RS44505"
                     /old_locus_tag="O1M07_44490"
     CDS             16038..17660
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941300.1"
                     /locus_tag="O1M07_RS44505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44490"
                     /product="serine hydrolase"
                     /protein_id="WP_189868191.1"
                     /transl_table=11
                     /translation="MSAARTAPHGSPTAAPAAHPLFSREWLWHAEATAGQRPEEGGALR
                     LGLRLTDPPVGVAGQILVLTDLATGALWFRAGEWDERPTLVLTLRHEEAAVLLFGDGER
                     RVRLFEHGRLVLEGVFLFIFFLDRLLQQDPSGALARLRGFTADAPQAAGPWPGTAAAVT
                     APDAEAEAARAATEALPHTMGALRAELGRTTPGAQLHVSHAPSGTTVSAALGSCRPGVP
                     FTRASLPIWYCCSKTLGAVAIGQLWERGLLDPAAPVARYLPWYDGDGRERVTLYQLLTH
                     TSAVPMGLDPLHGAMAAPVALRREQLRNMTVPAGTPPGARINYGPWWAWFLIAEVVRAV
                     DGRDYERYLAQEILAPCGMTDTRVVLTPQEYRAEADRLPLIHITGGGLPAQPTHWYATE
                     ASCARPIPGLNIRGPMSDLALFFAALASGGRGRHGRILLPQTVMALTAHHRVGLVDPFG
                     NADWGLGFRVESRHLGDECTAFSRHASPRTFGHYGLWTSAAFADPDAGLVVALHLNGKT
                     WQEEHQERMITIGDAVYQDLRLT"
     gene            17719..18819
                     /locus_tag="O1M07_RS44510"
                     /old_locus_tag="O1M07_44495"
     CDS             17719..18819
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016579249.1"
                     /locus_tag="O1M07_RS44510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44495"
                     /product="methyltransferase"
                     /protein_id="WP_189868192.1"
                     /transl_table=11
                     /translation="MTTPQPEDAFPADSPHAIIDVAIAFWKSKALLSAVELGVFEELAV
                     RPATGAELTGRLGIAGRGAADFLDALVSLGLLERDGGVYRNSPIADRYLDPRKPATDIS
                     GYLSFLNAGFGCWAGLTDALRSGGRLDFSAALAASQSADQARAGDPKLVGADATDDTFG
                     EAYAAPDQVTGFLRAMTGYSMGANQAIAERYDWSRSRTVADVGCAEGSLLAQVLSRNPH
                     LQGIGFDLPVVGPGFDAHLERVGLTDRARFAGGDFFTDPLPTADAIVMGHVLHDWDLDT
                     KKTLIGKAYEALPEDGRLLIYESLIDDDRRERTTGLLISLNVSTVSAGGLGYTGAECGD
                     WMRAVGFRDIAVSHLDGPEYLVVGVK"
     gene            18941..19072
                     /locus_tag="O1M07_RS44515"
                     /old_locus_tag="O1M07_44500"
     CDS             18941..19072
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS44515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_44500"
                     /product="hypothetical protein"
                     /protein_id="WP_268254091.1"
                     /transl_table=11
                     /translation="MPRRAAGAAVLLVSVCVPVAYADEKGAGVCDTSGFLGVCPVEG"
     gene            complement(<19108..20376)
                     /locus_tag="O1M07_RS44520"
                     /old_locus_tag="O1M07_44505"
                     /pseudo=""
     CDS             complement(<19108..20376)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009062240.1"
                     /locus_tag="O1M07_RS44520"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="O1M07_44505"
                     /product="IS256 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDTTIEQISGSEPAAEAVAASDEQLVAVLVDRARSEGLQLTGEG
                     GLLQQLTSGCWSPLWRARSPITSDTRSTMPRAVAAATAATGPGRRRC"
     misc_feature    20566..20581
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.1"
                     /tool="antismash"
     gene            complement(20874..21191)
                     /locus_tag="O1M07_RS44525"
                     /old_locus_tag="O1M07_44510"
     CDS             complement(20874..21191)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015422.5"
                     /locus_tag="O1M07_RS44525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44510"
                     /product="helicase associated domain-containing protein"
                     /protein_id="WP_229922394.1"
                     /transl_table=11
                     /translation="MIWSVPDARFWKNLTAARAYYAEHGTLAAPKDAMIEDVAVGQWLA
                     NLRKPGGLGKDEKRAEVRRQALVAIDPDWNPAWPIDWQRHYAALADLLDQGATLAEVLP
                     G"
     gene            complement(21328..21825)
                     /locus_tag="O1M07_RS44530"
                     /old_locus_tag="O1M07_44515"
     CDS             complement(21328..21825)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS44530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_44515"
                     /product="hypothetical protein"
                     /protein_id="WP_189868223.1"
                     /transl_table=11
                     /translation="MMASASYRPLVAVLQGLRARDERIVERMIVASRGARGKATSVVAL
                     DPQREEEEEQQAAGEGGQEPAAVEDLGAGTPEEGEGGQERGAGRGEAGREQDEDQEDEK
                     KGVPLLRFSLPRNPDVIAAFLRTRVLRPDSQVWLAGYNALRKWVESTATRRCRWTRWSR
                     SG"
     gene            complement(21872..22471)
                     /locus_tag="O1M07_RS44535"
                     /old_locus_tag="O1M07_44520"
     CDS             complement(21872..22471)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS44535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_44520"
                     /product="hypothetical protein"
                     /protein_id="WP_189868224.1"
                     /transl_table=11
                     /translation="MDDVDLYGPVLYELGLLESIEWRILARFEIDVLEIRDPETPGLDA
                     SVEEVRGRRLAALQAALLKHADACGVQSLMTFHSRTLDAMSLARALPETAAGLHETDPA
                     VYPKRVGAEWLCGEHSAQHRRTVLDRFADGLDADGWVTDFSVLASCQVLGEGVDIRGKR
                     GVQVWCSLIRAPRRCRSCRSPAGACGRTPGRGRSRG"
     misc_feature    complement(22586..22597)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(22894..22908)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            22900..23178
                     /locus_tag="O1M07_RS44540"
                     /old_locus_tag="O1M07_44525"
     CDS             22900..23178
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012334.5"
                     /locus_tag="O1M07_RS44540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44525"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_268934431.1"
                     /transl_table=11
                     /translation="MSDPVVLITGALTGIGRATALAYARQGANLVVSGRHEDVGEQFAR
                     ELTDLGAPCQRPCGAPRRRPVVLPAGGRLGVPAGGQLSPRQWLVWIS"
     misc_feature    23119..23121
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23143..23145
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(23171..23962)
                     /gene="istB"
                     /locus_tag="O1M07_RS44545"
                     /old_locus_tag="O1M07_44530"
     CDS             complement(23171..23962)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="istB"
                     /gene_functions="other (smcogs) SMCOG1151: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003944771.1"
                     /locus_tag="O1M07_RS44545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_44530"
                     /product="IS21-like element helper ATPase IstB"
                     /protein_id="WP_189868233.1"
                     /transl_table=11
                     /translation="MATPLRTVPGTNGDPLAEAIELTKRLKLPHIRRSLTDIIPTAKAQ
                     RWDPAEVVRVLLAEEAAGRDRANLHTRRKRAGFPTGKTFGDWHEGKSSIPRPTQDALKS
                     LEWVGRRENFCICGPSGTGKSHFTEALGQTAVEAGLTVAWFTIEDLGALVRRHRADDSI
                     ARALAKIVRSDLIIVDDIGLLPVSEDAAEGFYRLVDAAYERRSIAVSSNLHPSGFDEIM
                     PKTLATATVDRLLHHAHVTVTQGDSFRFTEATTGKGVKPFS"
     misc_feature    24075..24089
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    24210..24224
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    24886..24900
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
ORIGIN
        1 ccggtcgagt tcggccaggc tctgcagcgt ctgtacgacg acggatgcga ccggttcgtc
       61 gagtgcggag cccgctcggt cctcgccgac ctcgtcggag acgtcctgcc gctcgcggca
      121 catgcccgct ccctgctgcc ccggcgcctc acccgcgagg agttcaacga actggccggt
      181 ggccggtacc tctccgacac ccccgtgcca tccgagaccg gtctcccgcc tgtcgacacc
      241 ccggctccgg caaccggccc gagccagggc gccgtacaca caccggacac ggaccgaccg
      301 cagccgacgc gcgccgcaga cggcgccgag ccccgccccg gcgtggggag tctgccggcc
      361 gactccgagg aactgcaccg ccaactgcgc accgtctacg cctccgtgct gcagtacccc
      421 gaggacgtgt tcaccccgga tgccgacctc gaagcggacc tgggagtctc ctcgatcaag
      481 cagaccgaga tcttcgcccg ccttctggac cgcttcaacc tgcccactcc gtcggcggac
      541 acccgggtct cggcctaccg caatctgggg cgcatcgccg gactgctgcg gtccctggcg
      601 gatgactcct gacgcaccac atgacgacat ctgcggaggc aacctgtgac tgaccgcgca
      661 cgcaccaccc gtgagcccgg accggtcctg cccggactgg cgcgggatca gtacgtcgcc
      721 atcgtgggca tgggcctggt cgtccccggc gccgacaccc cggagcggtt ctggacactg
      781 ctgcaatccg acgacgtcgc cctgatcggc cccacccgct tccgctcccg gccgctgacc
      841 gcctcccgcg agccggggga gcgcagctcc ggcgcccgcg cgggcttcgt ccgcgccttc
      901 gagccgcacc ccgtcctcgc cgcgaacctc gccgccggcg acctcgacga cgtccccgac
      961 gagacgctgt ggctgcgcca cagtgctctg cacgccctca caggggtgac tgtccggcct
     1021 gacgaccggg tcactcatgc cttcggagcg tggacccaca gcacgcaggc gatggaggac
     1081 accctggtgg tcgaggagat cgccgagagg gtggccaggg agggcgccga tgagcccttc
     1141 gagcagatcg ccgcgtgcca ccggcagcgg cgccggctcg gcgagcactt ccgccacgcc
     1201 cgtcagcgcc ccgccgacgc cctgccaggt gccgtgctcg cccgcgccct cgaaggactc
     1261 acccccgagc cccgagaggt cctcctcgtc gacgccgcca gcgcatcgtc cctgtacgcc
     1321 ctgcagctgg cttgggagca actgcgcagc ggggaaagcg acatcgccct ggtcggaggt
     1381 ttcaacaacg tcggccgcct gggcatggca cagctcacgg ccttccgcgg catggccgcc
     1441 tccggatgtc tgcgggccta cgacccggcg gccgacggca ccttgttcgc cgaagccgcc
     1501 gcagtcctcg cgctcaagcc gctgggccgc gccatcgccg accatgaccc catccgagcc
     1561 gtcgtcggcg ccgtcgccac cgccggcgac ggccggggtg cccatatcgc cgtacccaac
     1621 ccgcgagggc agtcccgagc cgtctccgac gccatgacca ccgcctcggt caccactgac
     1681 gacgttgcct gggtgatcgg ccacggaggc ggctccccgg tcggggatcg gatcgagcgc
     1741 gccgtcctga cggagctctg gcgggacaca ccgctggtct gcgcgtcgaa caagccgcac
     1801 atcgggcacc cgtcgtgggc agcgggagcc gtctcgctta tccacgcggt cctcggcctg
     1861 caccaccgcc catctgctgg ccacctgccc ccgtcgtccc gcccgctcac cgccgccggt
     1921 gtcaccgcga tcggcctggg cggggccaac gcccatgcga tcgtccacga ccggcaccac
     1981 gcccgccctc cggtcgccca acgccctcgt gacgacacca accccgtcgt cgtcggctgg
     2041 agcgccgtgc tgcccggacg cccggaccgc caccagatcg ggcacctcct gcgcaccagg
     2101 accgcacagc gcacctactc ggccgccgac ctcgacctgc ccttcgacgt cacccggctg
     2161 cctcccgcgc tgcagccctc gctggatccg caccaactgc tcgctctgga cgcggcccat
     2221 gcgctggtcg ccgtacaggg cgagttgtgg agcaggcacc gcgacaccac tgccgtcgtc
     2281 gtcgcgacgc cgctgccctc accccgcctg tcggccgtca ccctccggtc ggcgatcccc
     2341 gagctctccg aacttccctg ggaaggacaa gacgccgtcg cctgggcgcg ggtccgcgcc
     2401 ggtatccggg agcggacacc ggtctcggaa gagaccatgc ccggcatcgt ccccggcgtc
     2461 gccgcaggca gggttgccaa caggtgggac ctgcgcggcc ccagcatggc cctcaccggt
     2521 cccaccgcgg gccacgccgc cctgactgcc gccaccacgc tgctggccgc cggccgcctg
     2581 gacatcgccc tggtgctcgg cagcaccctg ggcgcaggac cgttgcacgc cgcgttcgcc
     2641 gagacccacc cgggctcgct gcgcgaaggg accttcctgc tggcggtcac caccgctggc
     2701 ctcgcgtccc gtgccggctg gcccgtgctg ggcacgctcg acaccgatgc cgagcccccg
     2761 gcgtggacca cgacccgtac cgaccgcccc accggctact tcggcatcga ccccatcgcc
     2821 gaaaccgtcg cgcggctggc cgcttcatcc ctcgcctgcg caccttccac agctcgtcgc
     2881 cgaacggagg acgatatgcc cgacgcggcg ccccgaccag cggactcccc acccccacaa
     2941 ccggattcga ggcagcattc cgacccagtc tccgcccaca ccacgcgtac cgcgctcgtg
     3001 ctgcgccgct ccgccctgcc acctgcgaac cacggggcgg agcgggtcgg tgccttaccg
     3061 cccggatgcc tggtcctgac caactcccac gcgctggccg ccacgctcac ccggcgttgc
     3121 cgggctcgtc gggccctgct cgtcagcacc gataccgctg acggtccacc ggccgagggt
     3181 gtgcaccagc tggcgggagc gggcggcgcc gagggactga aggagcagct catctcgttg
     3241 cgcccgcacg tccgcgtgat cgccgacgtc cgtgcggccg cggcgccgtg gcctggcccc
     3301 gttcccgcgg cacttgccca tctccacgac gccctcctga ccgcgctcaa agcgttcggc
     3361 gctcgcatgg ccgacggctc gctcgcggtc attgtccacg acaccctcac tgccggtctc
     3421 gtccgccctc atggtgcgct gctgaccggg atggtccgca gtctcgcctg ggagcttccg
     3481 cgccggcaca ccctcgcgct cgtcaccgac gcaccgcccg accaggccct gaagcaactg
     3541 gccaccgaac tcgccgccga tcgagaccgc cctgtcgtcc actacagcaa cggcacgcgc
     3601 ctcaccgagc acctcgtcgc ctcccctctg ccggcggacc gggacctcac cagccccttc
     3661 gcccccggca gcgtgatcgt cgccgcgggc ggagcccggg gcatcaccgc caccatcctc
     3721 tgcgacctcg ccgcgcgcca ccgaccggcc atctggctcc tgggcaccac atccatcgac
     3781 ggactcggtg aggacctcgc cctggcagcc gccgaagacg aaggcaccct gcgcagaaag
     3841 cacatcgccc aggccgtctc cgcgcacccg ccgcgcagtg tcgccgaggc caaccgggag
     3901 ttcactgccc tgtggcaggc acgcgaggtg gtcgccaacc tccggcgcct gcgcgcgctg
     3961 tgcggttctg accgggtgcg ctacctgcgc tgcgacatca ccgacgcccg agccaccgca
     4021 cgcgccgcgc acaccatcct cgccaaccac ccccggatcg acctgctcat ccatgcggca
     4081 acccgcagcc gcccggccct gctggcggcc aagacgatcc aggacgtcca ccaggtactg
     4141 gacaccaagg tcggcggcta cctcaacctt cgggcagcct ttgcacagtc accccctgcg
     4201 ctctggtgca acttcgggtc ggacgtcccg ctcttcggca tccccggaga cctggactac
     4261 gtcgccgcca acgcgttcct gagcgccgcc gcccgctaca actccgcact cggtaccaga
     4321 caagagatca cgatcggctg gggtctgtgg accgagtccg gcttcgccgc gggcgaactc
     4381 gaacgtgaac gcacccggcg gctgggactt gccaccggac tgaccgacgc cgaaggcacc
     4441 gccgcctttc gcagagagat cgcgacgccc ccttccctcg aagcgaaccc gctgtggacc
     4501 agttccagcg agcgggcact ggccgaacgg cactcgcccg gtatcaccag tgccctcgac
     4561 ccggccccgc cgacgccccg caccctgctg ggcgcccccg accaccgcgg caccgaccac
     4621 gcccagtgga cctggacact tgacccgcac cgtgacacct acctgctcga ccacaccctc
     4681 gaccagcgcc ccctcctcgc cggcaccctc ttcctcgccc tcgccgccga agccgccgac
     4741 accctcatgc ccgatacccc ggcaacggca accgccatgg agaatgccca gttcgaccag
     4801 tacgcatggg cggaccccac tcgccccggc cccaccaaat accgcatcgc cgcccgccgc
     4861 agcggcccca cccggatcca tgtggcgatg cgctccgaca tcaccacgcc cgacggaaag
     4921 accctcctca aggaccgccg acacgctgcc gtcgacatcg tcctcaccac ccccgcaccg
     4981 cacaccatcg ccaaccccac ggaaccggct cccgcggcac aaccgcccga caccgtccgg
     5041 ccccccgcat cccgtcgccg gaccgatccg acatgggagc cacaatcccc gctccggctc
     5101 tacggcccct tccacaacct ccacgccctc gaacagtcgc cgacccgtgt ccgagcccgc
     5161 tggcacgcac acctcagccc gcacgacacc accgcgcaac tgcgcctgcc ggccctgctc
     5221 ctcgacgcca tggtccgcac gaccttcttc accgccggcg agccgcagca tgcccacatc
     5281 cgcgtgttgc gcggcattgc ccgcattgac ctgccggccc accgctccga tcgcgacctc
     5341 gccctactcc accccgaagg gatcgagctc acctgcgata tccccaccaa cgactgcacc
     5401 gcgaccaccc gctcaggccg gctcgtcgcc agcctcaccg gcgtcgacac gcccgctgtg
     5461 gcgcgcatcc ccaccttgcc cgtacggaac ccaaggacac cgcgatgacc cgcagttacg
     5521 acatcgaact tgtcgccacc accggcgaca ccaacatggt cggcaacgtc tacttcgcga
     5581 cgttcctcag gtggcagggc atgtgccgag aactctgcct ggcggaacac gcacccaagt
     5641 acctccagga actcgacggc gagatcaccg cgctcaccga gtccgcctcc tgcacctacc
     5701 gcgacgaact ctgggtgggc gatcgcgtct ccatccgcat gaccattccc tggatccgcc
     5761 tgcacctgat gccgttgcgg ttcgagtact accgcctcac cgacgatggc gaacaactcg
     5821 tcgccaccgg ggagcagatg atcgcctgca tgcgcaagca cggccgctcg ttctcgcccg
     5881 gcccctggcc cccggaaatg ctggcgctcg gcagccacct gggagccgac atccaccgcg
     5941 ccttcacgga gtgaccccgg cgcggtggcg tgccgtgaga cggcggggac ggcggctccc
     6001 cgatcgccgg ggcacggtct actgcgcggc tcctctgctg tcgccggggc ggctgcccgc
     6061 cgtcgccggc cagtgtcgct gccgagctgc tgggcgttgg tctgccgggt gccgcgcccg
     6121 gttcgccgtg cgcggtcggt cgccctcgtg gccgcggcga agtggatgtc gcagtacccg
     6181 agcgagctcc cggcgggctc ggtgagcagt ccgatgtctc cgcagcggcg gctccggctg
     6241 cgcgaggcac cgctggcccg caccggcgcg gagttgggag aggtgctcga cttcgtgcgc
     6301 gaggagatcg cgcccttccc gacgggcaac gggcaccccg cgttcttcgc ctgggtcaac
     6361 tccccacccg caccggccgg gatcaacgcc gagctgctgg ccagcgccat caacgcgacc
     6421 tgcggcatgg gtgagaacgc cctccgccgt cgagcgctga gccgcgtccc cagcctgacc
     6481 tcgtcggcgt tcgaggaacg gtcgccgtga ctgctctcga atgcttccgc cccaactccg
     6541 cccgggcgcc gcccggcgac cgcgaccgct tgaccactgg gatgcttcgc ggcccgacga
     6601 agaagtatgt cgagtcattg atccgtccct gtggggcatg ggtgtcggcg tacaagaggc
     6661 ggccgcgggc cgaacgggcg gtcaggcagc gaggggccca cgacagggct ccgccggtgg
     6721 ccgcccgccg gcctgcggca agacggtcta caggcacagg cactccgtcg agtgcggtgc
     6781 caaccgcctc aaaggcaccg tgcggtcgcc gcgaggtacc acccggcccg gccccgacgc
     6841 cacgccatcc acatcaagat cattacgtgt ctggccaggt catgcgggac atcgtccgga
     6901 gagaatgctg ccccggaata ggggatttcg cgactttcgg catgcaggat tcaactcggg
     6961 cgccctgcac cgaggggcgt cgtgtgcacc gaggtggagg agtgtgggta tgggcagtgt
     7021 gcttctcgaa cgcgaggaag cgctggcggc cgcggcgagg gccggacagt ccgcgcggtc
     7081 cggtgcgggc cgttggctgg tgttcggcgc ggcggcgggg acgggccgca ccgccctgtt
     7141 gcgggaggtg gcggggcggg aggcggcggg cggggcgatg cgtgtgctgc gcgcggactg
     7201 ttcgccggag gagtcggggt tccccttcgc tctcgtgcgc cagctctttc ccgaggacgg
     7261 ggaggtgcct ttcgcggacc taccagcggc cgaggagcag atggtcttcc accgccttgt
     7321 gacccgctta gcgcggactg ccgaccgtcg gcccgtactt ctggccgtcg acgacctgca
     7381 cgatgccgac atggcgtcac gccgttggct cggctacctg gcccgtcggc tggcggccct
     7441 gcccgtgctg ctggtcctga ccgagtgccg ggagaagggc accgccgtgc tgcccagtgc
     7501 gacgggcacg tccgtggtgc tccgcccgct gggcccggag gccgtggccc gtctggtgtc
     7561 cgcccacgga cacggcgccg accgggccga gttgtgtgtc cgggcgtgcg ccggcaatcc
     7621 ggttctggtg cacgccctcc tcgccgacct ccgtgagggg ccgctgcccc gcagtctgtc
     7681 cgagctgggc ggaagccgct accgtgacgc gatcgtccat tggatacggg cccgggcgac
     7741 cccgtggtcg cgccgcctct ccctggcgct cgccgtggcc gggggcggcg ccgcgctgct
     7801 cggcggagct ctgctccacg aggccgccgg cctccgcccg gaccaccgcg ccgcgtccgc
     7861 gggcgcgtcc gccctccgcc gcctcttctc ccacccgctg gcacgcgagg ccgccctcgc
     7921 ggcggtcgat ccggccgaac tcggcgcgct gcgcggtcgt atcgcccgcc tgctcgacga
     7981 gcgcggcgcg cccacggcgg acgtcgccgc ccagctgctc cacctcgacc ggcccggcga
     8041 ggagtggatg acgcagtccc tggaggacgc ggccgaggac gccgtacgcg gcggccgggt
     8101 cgacgaggcc accgctttcc tccgccacgc cctcaccgct ccgctcgccc ccggccgccg
     8161 cgccgggctc accctgcgcc tcggcgccct ggagctgccc cacagcgcgg atgccggcat
     8221 ccgcaggctg cgtgcggcgc tggagctgca cgccgaccgt catgaacgcg ccgctgtcgc
     8281 acccgccctc ggcgcggcgc tcgtcgcccg gggccgcacg gacaccgcca tgcgcgtcat
     8341 gcgccaagtg ggcagcgccg tggacgacgg cgagctcgtc cgtgtgttgc agaccaccgc
     8401 cgccgttatg gcctcccacg acgcggtcgc gtggcgcaac gccgtcgccc gcatgcggga
     8461 actggcggcg acggcccccg ccgccgtcga gccgctcgcc tgcggcctgg tcaccgagta
     8521 cgaggtcggg accggccggc tgtcggcggc cgaggccctc ggccgtgtgc tgccgcggct
     8581 ggccgcaccg gtggaccccc ggctccgcga cggctggctg ggaaccgcgg ccaccttgct
     8641 gcagtgggcc gaccggctgg acgaggcacg cgccctcgcc gaagaggccc tccccgcccc
     8701 gcccgcgctc ccggatctga cggacatcgg ccgacagtgc ctgatcagcg tacgggccga
     8761 agcggccctg tgggccggtg acttccggcg cgtgatcgcc gagaacgccc cgctcctcga
     8821 cgcgtgcgcc gggcagggga tccgcatgcc ccacctggcg tccatggtgg cactcgccca
     8881 ctgcgaactc ggccaccgtg cccacgcccg gcggctgctg gccggcctcg acgaggagag
     8941 cgccgacagc tcctgggaat ggaacgaact gcactacgcc agagcctttc tgcacatggc
     9001 cgagggcaac tggcaggccg ccctcgacga ctacctgtcc tgcggccgcg gtcagagcgc
     9061 ccgcgacttc gtcagccctg tcgccacccc ctggcgctcc ggcgccgccc tcgccctggt
     9121 cggactcgga cagccggcga gagccctgga cctcgccgag gaggaactgc gtcacgcgcg
     9181 gacctggggg acaccccgca cggtgagccg ggccctgcgg gcccacgccg cggccgtggg
     9241 cggccgccgg gggctcgagt cgctcggcga ggccgcggcc gtgctgagaa ccgcaccggc
     9301 ccccgtcgaa ctcgtcgaga ccctcctcga cctgggccac gcgcggatcg acgccgggaa
     9361 cagccgcaag ggccgcgagg acctgcacga ggcccacgcc ctggcactgc gcctgctggc
     9421 ccccgacccc accggacacc cggacgcccc ggacgcgccc gccaccggac gcctgctccg
     9481 cgccaccggt aacgccctgc gggccagcgg cgcccgcgga acccgccggg acacgacggg
     9541 cagcgccgca ctcacccggg cagagcggcg catcgtcgag ctggcggccc agggccagac
     9601 gaacgcccag atcggcgagg tgctccacct ggcccgccgc accgtggaga cccacctcac
     9661 ccacgcctac cgcaaactcg gcgtgacccg ccgcacccag ctcgcctccc ggctgaccgg
     9721 gacgggcacg gcggcctcct ccagcgcgcg gagcctcacc acatccggct gaccagggcc
     9781 gtcgcccgcg ccgggcgacc accgggatcg tggatctcca cgatggccgt caagatcccc
     9841 cgcacggcag gctgacctga gaacaccagc cggaccagga gtgcctcctg atccggcccg
     9901 gccacaacaa gtccgttctc acgaggaatg cacgcctggc gtgggtggat atatgtcggt
     9961 atctgatgtt gcttcgcgtc gcaccgttcc cggcggggga gtgggggatc ctcatccgcc
    10021 gggcccgtgc gaagtgctgg aggggccgct cggcgtcggt gacctgctgg cggccgtgcg
    10081 cgcggtcctc gacggccacg gcggggcgcc ggcgcgaccg gagctgaccg tgcacgggcc
    10141 cggccagtac acggtgcggg tgggcggcga ccggctggac atccgcagcc ggccgctgtc
    10201 cgaccagccg cccggcaccc tggaccccgt cctcgacggg ccgggggccc gccggatcgt
    10261 gctcaccgcc tccggcgccc cctcggagcc ggcccgtgac ctgttcaccg cgctgaccga
    10321 ggcgatcagc cggcgggccc ggtgttacac cgaggccgag gccgccgcca tcgcggccgg
    10381 catgccgctg acgggccgtt atgcccagcc cgaaccggcg ctcgccggat gggcgttgat
    10441 cttccgggac cactatgtgg agaacagcgt cggcttcctg ctggccatgg agcgcgccgg
    10501 actcgacccc gagtggatct tcgcgctgtc caagggcgac cggacgcagc accgcgagcg
    10561 ggtgcactcc tggttcctgc gccgcggcta cgccagcgac accctggaca actccgtcat
    10621 caacggcacg gccggagcgg cggaagcggc ccgcgcacgg gcggtggacg cccaggtggc
    10681 caacttcgtc cgccgggcgc acgccgccgg ccgcaaggtc ctggtcgttg acgacggcgg
    10741 cctgctcgcc cagggctacg gcgccgacgg gccgggaccg cgggtggacg ccgccatcga
    10801 gctgacggtc agcgggctca agcgcatcac agccgccccc ggcgaactgg ccgtccccgt
    10861 gctgaacatg gcccgctccc agctgaagtc acggctgggc tacaacgaga tcgccgactc
    10921 ctgcgtgcgc cggctgcggg cgatcgtgcc cggccagaaa ttcatcggcc ggcacgtcct
    10981 gctgctgggc tacggcaccc tgggcgcacg ggcggcccgc tcgctgcggg cgctgggctg
    11041 ccgggtcgcc gtggtggaca ccgacatcct ggcactgatc accgccgccg aggacggctt
    11101 cgagacccac cgcagcatcg ccgaggccct cgaccggcag cggccgttcc tcatcctcgg
    11161 cagcagcggc ggcaccgccg tcaccgccga ggacgtgccg ctgctgcccg acggcgtgct
    11221 gctggccggc ttcgccacca aggacttcag cgtgctgacc gacggttacc ccggtgccac
    11281 cgcgcagcgc atcccgcacg tcggcgtgcg ctacgacctg ccgcacgcca ccaccgccac
    11341 cgtgctgggc gacggccgtt cgctgaacct cttcgagtac gagggcatcg ccaaccgcgg
    11401 ctacgacgcc taccgcgccg gcaccctgct cgccgtgctc gccctctgcc gtgatccgga
    11461 acggttcccg cccggcctcc acctggagcc ggtggaccgg atcatcgacg acgccgggct
    11521 gttcgacgcg tactacaccc agtacctgtg cgcgcggtcc gccccgctgg gcaccggagc
    11581 gttctccggc accgctgaga cctccggtga ggacgcccat gcccggtagg ccgcatgtgt
    11641 gcgtcgtcgg ccacggcgtg gccggccggc tgcaccacca actgctcgac ggcatgggca
    11701 tgtccgtgtc cgtcgtggac cccaccgccc ccggctgcgg cgcccccttc cctaccgccg
    11761 ccaccgtggg ggaactgtcc acggaccggc cggtggacgt ctggtcggtc tgcaccccga
    11821 ccgccggcca cgtacaggcc gtggccgccg tcctcgcccg cgaccccgag gcccgcatcc
    11881 tgctggagaa accggcctgc cggtcctggg agggccccga actcaccgcg ctgctcggcg
    11941 cgtacgaccg ggcccggctg gtggtgatga accagtacgc gcacgccaag gctcccgcca
    12001 tactcgaggc cgtacgcgcc gagttcgccc cccggcaccc ggtggcggcc atccgcgtcg
    12061 ccttctgcaa ggaccgccgc gaggacatcg cggccggccg cttcgtcgac ctcgactacg
    12121 gcgtcttcgg ctacgagtgg ctgcacatgc tcgccgtcct cggcggcttc ctgcccgccc
    12181 gggccttcca ccactatctg ctggccgggc ccgagccaca ggccgtacgg atcgcccgtg
    12241 acccccacct ggtcagcacc gcggcccacg acaccacgac actgagcgcg ggtgccggcc
    12301 ccgcgggcga ggtcgaggtc gagctgtact ccaccatcat cggccccgac gccccgcacg
    12361 cggcccccgc gccctcctgg gcccggcgca ccgcacccgc cgccgacagc cggctgcggc
    12421 tggcccggat cgaggccgga ccggtcctcc tcaccctgga actcgacccg gtcttcctgc
    12481 ccaacggcac ccggctgccc cgcaacaccc accggctgac catggacggg ccgcacggcc
    12541 accgcgagtg gctgatcccc gactccccga tggacaacgc gctgcggcac ggcatcgcgg
    12601 ccctgctcgg ccccggccca cgccccgcgc tggacctgcg gcccctcgac cgcatcggcc
    12661 ggctggccga actggcccgc gccgaacgcc ccgcgccctc cggccccccg acccccgccg
    12721 ccctgacgac ccgactgtga gagtgaaccg cccatgagcc ggatctgcct cgtcatcccc
    12781 agcaacaagt tcgaccagta cttcatccag ctccccctgg acgccgtcac cgccgccggc
    12841 caactgaggg cggagggcca caccgtcgcc gtgtgggacc agcggctcca ggaggcgccc
    12901 gacggcgagg agttcgacct gctggtcgtc ttctccgcga tcgccgaccg cgcccagtgc
    12961 tacccgctgg agttgggctg cgtgcgggtt gctgttgagc gtgctgtgtc ccgctatccc
    13021 gcggcccgta ctgtcgcggt tggtccgcat ggcacgcacc tgcccgtttc cactcgcgct
    13081 gagttgggtg tggaccacat tgcctgtggt gaggccgatt cggctaccgt cggtgcggtt
    13141 cgcgccctgc tggccggcgc tgacgcatcc gtgctcccgg gcgccgccgc cccgcacaat
    13201 ctgctggagt cacccgagtc ccgcccccgt ccctttccca acctccgcct ggaagaactt
    13261 gccttccctg cctatgacct ggtgcccacg gccgactaca cggctgaggt catctctggt
    13321 gggttgccgc tgcctggtcc ctgtggcatg gtgctcgctg cccgtggctg cacctacggc
    13381 tgtaccttct gccacctgcc gttcggcacc aagatgcgta accagccgct ggatcgggtg
    13441 gtgtgcgaga ttgaggccca gcaggccgcg ggtctggagt ttgtgttctt cctcgactac
    13501 gtgttcggta tcaatcgcgt cttctacagc gagttgtgcg cccggttgga gggtcgcggg
    13561 gtgggctggg tgggccagac ccgcgccgag gtcgtcctga agagcgacgt cgccgcttgg
    13621 gcgcgggccg gctgtcaggg catgtggctg ggcgccgaat cgcctgccat cgccgacacc
    13681 ggtgtccaca agcgggtcag tgaggcgcag attgaggagg ctgtcctgaa gctgcgggac
    13741 gccggcatca cccccttcgc cttcgtcttg ctggggttgc cgcaggatca ggcgtgcgtc
    13801 tccggtcgcc tggtcgactg ggcggcgaag ctgccggcct ggttcggtat caaccagctc
    13861 tatctgcggc cgggcaccgc cctctacgac gagctcgccc ctcggtacaa cggtggggtg
    13921 ctgcctgcca cctggcgcga ggttcaggag gtcacccgtc gctaccgtgc cgcctacccc
    13981 atcgacctgg accagcagca gcagcggctc atcgaacttc ccaactacct gggcaacgcc
    14041 attgctccgg tggcgggctg aggaggcggt cgtgctgcgc ttcggcattc tcggttgcgg
    14101 ttcgattggt ggcttcctgg gccgcttgct ggctcggccc gatggcccgc tgcgtgagcg
    14161 ggcctgtctg gtggcggtcg ccggacggga cccggttcgg gcacgccggc tcgccgcgga
    14221 actgggttgc gtcgcgctcg ctgtccccga gttgctggcc cgcatggaca ttgacgctgt
    14281 cgccgtgtgc actccctccg gtacccacgc cgaactgggc tccgcagccc tgcgcgcggg
    14341 caagcacgtc ctggtcgaaa agcccgtcga cgtcaccccg gaggccgccg accggctggt
    14401 cgccgtcgcc cggcacaccg gccgcaccct gggcgtcatc tcccagcacc gcttcgaccc
    14461 cgctgccgaa gtggccaggg ccgccatcga ggacggcact ctgggccgga tcacgtcggt
    14521 cctcatcgag gtccccctgt ggcgggcgcg gtcctactac gcgtcggggc agtggcgcgg
    14581 cacccgtgcc ctggatggcg gtggcgccct gatgaaccag gccgtgcacg ccgtcgacct
    14641 cgcccagtgg ctggccggcc ctgtggtgga ggccgccgcc cacaccggcc tgctcgccca
    14701 cgacggtatc gaggttgagg acgtggccac cgccagcctg aagttcgccg acggcgcgct
    14761 tggggcgctg ctggccacca ccgccgccta cccggggcgt accacccggg tcgcggtcaa
    14821 cggcgagcgt ggatcggtcg tcatcgacaa cgacgagctg gcctacttcc acaccgcccg
    14881 tgagggcgag cggcccgccg cctacggcgc gtacggcgac ggcaaccagg ccgccgaccg
    14941 gtgcccgccg ccgcgggagc ccccgccgcg cgatcgcgtc ggcctgctcc accagcccca
    15001 ccgcgaccag ctggccgact tctgcgacgc ggtccgcacc ggccgaccac ccctggtcga
    15061 cggcgccgcg ggacggcggg cggtggcggt ggtgcacgcc gtgtacacct ccgcccgcac
    15121 cgggcgcacc gtacggctcg acgagagcgg caacctcaca caggacaagg ggaggacccc
    15181 atgagcggga cccttcggca cccggcgccg gacgagcaca agcaggccct ggcccggctc
    15241 ttcgaccgca gcgccccgac gtacgaaaag gtcggtgtct cgcacttcgg cgccctcggc
    15301 cgccagttgg tggaggaagc ccgcgtccgg gagggcgagc gggtcctgga cgtggggtgc
    15361 ggcaccggcg ccgtgctcgt tcccgcggcg cgggccgtcg gaccgagcgg ctcggtgacc
    15421 ggcatcgacc tgtccgcggg catggtggag cggtcccgcg cggccatcgc ggaagaaggg
    15481 ctgagcaacg cccgcgccct ggtcgccgac gccgagaccg cccactggca gcccggaccg
    15541 cccgtggacg gcaccttcga cgcagtactc gccgggatct cgatgttctt cttcccccac
    15601 cccagggccg cggccgcccg ctaccgccga ctcctcgccg gcggtggccg gttcgccatc
    15661 tcctggtggg gccgccagga cgagcgctgg aacccggtct tcgccgccag tgccccctac
    15721 ggcggcgcct cctcccaccg gctcgcgccg gacagcccgt tccgctccgt cgaggacctg
    15781 cacgccatgc tgtccgagga gggcttcagc tccgtcgaca ccgtggagcg ggcctgtgtc
    15841 acccgcttcc gcggccccca ccagtggtgg cggtgggtgt ggtccaccgc gggccggcag
    15901 ttctgggaga gcgtgcccga ggacgcgatg gccgacgcgg tcaaggcggt cgaggccgag
    15961 ctggccgcac tgcgcgcccc cgacgggagc ctgaccagcc ggagcatcgt ccgcttcacc
    16021 gtcgcggagg tcgctcggtg agcgccgccc gcacagcgcc gcacgggtcc cctacggcgg
    16081 cacccgccgc ccacccgctg ttctcccggg agtggctgtg gcacgccgag gccacggccg
    16141 ggcagcggcc cgaggaaggc ggggccctcc ggctgggcct gcgcctgacc gatccgcctg
    16201 tcggggtggc cgggcagatc ctcgtcctga cggatctggc caccggcgcc ctgtggttcc
    16261 gcgccggcga gtgggacgaa cggcccaccc tcgtcctgac cctccggcac gaggaggccg
    16321 ccgtcctgct gttcggggac ggcgagcggc gggtgcggct cttcgagcac ggacggctgg
    16381 tcctggaagg ggtgttcctc ttcatcttct tcctggaccg gctgctgcaa caggacccgt
    16441 ccggggcgct ggcccggctg cgggggttca ccgccgacgc gccgcaggcg gcgggcccgt
    16501 ggccgggcac cgccgcggcg gtcaccgcgc cggacgccga ggccgaagcg gcccgcgccg
    16561 ccaccgaggc gctgccccat acgatgggcg ccctgcgcgc cgaactcggc cgaaccaccc
    16621 ccggcgccca gctccacgtc agccacgccc cgagcggcac caccgtctcc gccgccctgg
    16681 gcagctgccg ccccggagtg cccttcaccc gagcctccct gcccatctgg tactgctgct
    16741 ccaagacgct gggcgcggtg gcgatcggcc agttgtggga gcggggcctg ctggacccgg
    16801 cggcgccggt cgcacgctac ctcccctggt acgacggcga cggccgcgaa cgggtcaccc
    16861 tctaccagct gctcacccac acctcggccg tccccatggg cctggacccg ctgcacgggg
    16921 ccatggccgc cccggtcgcg ctccgccgtg agcagctgcg gaacatgacg gtcccggcgg
    16981 ggacgccccc cggcgcgcgg atcaactacg ggccgtggtg ggcctggttc ctgatcgccg
    17041 aggtcgtccg cgccgtggac ggacgcgact acgagcgcta tctcgcccag gagatcctgg
    17101 cgccctgcgg gatgaccgac acccgcgtgg tgctcacccc gcaggagtac cgggcagagg
    17161 cggaccggct gcctctcatc cacatcaccg gcggcggcct cccagcccag cccacccact
    17221 ggtacgccac cgaggcatcc tgcgcccggc ccatcccggg cctgaacatc cgcgggccga
    17281 tgtccgacct ggcgctgttc ttcgccgcgc tggcgagcgg cggccggggg cgccacgggc
    17341 gcatcctgct gccgcagacc gtcatggcgc tcaccgcgca ccaccgggtc ggcctggtgg
    17401 acccgttcgg caacgccgac tgggggctgg gcttccgcgt cgagtcccgc cacctcggcg
    17461 acgagtgcac ggccttcagc cgccacgcct cgccgcgcac cttcggccac tacgggctgt
    17521 ggacctcggc ggccttcgcc gacccggacg ccggcctggt ggtcgcgctg cacctcaacg
    17581 gcaagacctg gcaggaagag caccaggaac gaatgatcac catcggtgac gccgtctacc
    17641 aggacctccg gctgacctga tgcccgggcc ccttgaagcg cccgcacacg cccgcaccgc
    17701 aggaacggag aaccgagcat gaccaccccg cagcccgagg acgccttccc ggccgactca
    17761 ccgcatgcca tcatcgacgt cgcgatcgcc ttctggaagt ccaaggcgct gctgagcgcg
    17821 gtcgaactgg gcgtgttcga ggagcttgca gtacgtcccg ccaccggcgc cgaactcacc
    17881 gggaggctgg ggatcgccgg ccgcggcgcc gccgacttcc tcgatgctct ggtgtccttg
    17941 ggactgctgg agcgcgacgg cggcgtctac cgcaactccc cgatcgccga ccgctatctg
    18001 gaccctcgca agcccgccac cgacatctcc ggctacctct ccttcctcaa cgcgggcttc
    18061 ggctgctggg cggggctgac tgacgcgctg cgcagcggcg gccgactgga cttctccgcg
    18121 gcgctggccg cctcgcagtc cgcggaccag gcaagggccg gcgacccgaa gctggtgggc
    18181 gccgacgcca cggacgacac cttcggcgag gcgtacgccg ccccggacca ggtgaccgga
    18241 ttcctgcggg cgatgaccgg ctacagcatg ggcgccaacc aggccatcgc ggaacggtac
    18301 gactggtcgc ggtcgcggac ggtcgccgac gtgggctgtg ccgagggctc gctgctggcc
    18361 caggtgctgt cccggaaccc gcacctccag ggcatcggct tcgacctgcc cgtggtcggc
    18421 cccggcttcg acgcccacct cgaacgggtc ggcctcaccg accgggcgcg tttcgccggc
    18481 ggcgacttct tcaccgaccc gctgccgacc gccgacgcga tcgtgatggg acacgtcctg
    18541 cacgactggg acctggacac caagaagacc ctcatcggca aggcgtacga ggcgctgccg
    18601 gaggacggcc ggctgctgat ctacgagtcg ctgatcgacg acgaccgccg cgaacgcacc
    18661 acgggcctgc tgatcagcct caacgtctcc acggtctcgg ccggcggact gggctacacc
    18721 ggtgccgagt gcggcgactg gatgcgcgcg gtgggcttcc gggacatcgc cgtgagtcac
    18781 ctggacggcc cggagtacct cgtcgtcggc gtcaagtagc accgcgtacc cggccggtgc
    18841 cgtgtggcgc cggccgcgta ccccaccccg cacgcctccc gtcacgcccc gcggcgtcca
    18901 gcagccgggt gagcgactgc gcgccggacg gagcgcaccc gtgccaaggc gcgccgcggg
    18961 tgccgcggtg ctcctggtga gcgtctgcgt ccccgtcgcg tacgcggacg agaagggcgc
    19021 aggggtgtgc gatacctccg gcttcctggg ggtgtgtcca gtagagggct gatccagttt
    19081 ttgtaggggt cggttggcgg ccggggtgag tcggccttcg aaggcgatct ggaaggcgtt
    19141 caggggtgcc ttcgagcgcg tggtccatcg cttgcggctg ccggttgggt ccaggctcat
    19201 cagggccatg tagatgcact tcatggccgc ggtctcgttg gggaagtggc cgcgggcgcg
    19261 gacggccttg cggatgcggg cgttgatgga ctcgatcgcg ttcgtcgagc agatgacctt
    19321 gcggatctcg acgtcgaagg agaggagggg cacgaactga agcccaggcg ttctcccagg
    19381 gctggatgac cgtcgggtac tttttcctcc aggcttcttg gaactcgccg agccgctcgg
    19441 tcgcggcggc ctcgttcggc gccgtgtaga cgggcttgag cgccttggcg atcttgtccc
    19501 agtcctggcg ggccgcgtgc cggaagctgt tcctgggcag gtgaacgacg caggtctgga
    19561 ccaccgtgcg cggccatacc gtctccaccg cttccggcag gcccttcaac ccgtcgcaga
    19621 ccagcatcag gacatcgtcg acgccctgtt cttcaggtcc gtgaacatgc tcagccagta
    19681 cttcgcgtcc ccgccgccgt cgccggccca gatccccagg atgtcccggt ggccctcggt
    19741 ggtcatggcc atgacggcgt agaccggacg gttcgccgcc tggccgtccc ggatcttcac
    19801 gttgatcgcg tccacgaaca gcaccgggta aacgcgatcc agcgggcggt tggaccattc
    19861 cgccatcccg tccatcacgt tgtcggtgat cgtggagatg gtcgccttgg acacgctcgc
    19921 gccgtagacc tcggccagat gcgcgaaggg tctccccgcg cgtcagaccc ttcgccgaca
    19981 gcgacaacac cctctcatcc acccctgaca ggcgccgctg ccgcttcttg acgatctgcg
    20041 gctcgaacga acccgccacg tcccggggga ccttgacctc gaccgggccc acatcggtca
    20101 gcaccgtctt cgcccgggtc ccgttgcggc tgttgccgct gccacggccc tgggcatcgt
    20161 gcttctcgta tccgaggtga tcggcgatct cgccctccag agcggactcc agcacccgct
    20221 tgtcagctgc tggagcagcc cgccctcccc ggtcagctgc aggccctccg accgggcccg
    20281 gtccacgagc accgcaacca actgctcgtc actcgccgcc acggcctccg ctgccggctc
    20341 gctacccgat atctgctcga tggtcgtgtc gctcatccgg cgtctccttg atcatcggat
    20401 ccgccaatca tcgaacactc ctcccacgga aggaccgcag ggcgcctgca cgacactctc
    20461 cgcgcgacct accaaatccc gcatacccaa cccctcacgc caccgcccac tggagaccga
    20521 ggtcggcgag ggcctggagc ttgtcccccg tgagcttccc ccgcctcgac ctggtgttcg
    20581 acgagaaggc cccgagcttt tacagagtgc tcctggccgt cgaccacaac cgtctctacg
    20641 tggcccctgg ggacggtcaa cgagccggtg cgggctttgt attgcatcaa ggccgccacg
    20701 ccccgctcga aggccccaga acggcccttt agtcgccttg acaggcgtct gctgctcggg
    20761 aggcaagggc acgatgccga gggaccccag acgttctcgt tgctggtcgc tgagttgctc
    20821 ccagccctga acctgcgtgt ggtgccatgt gccgacgtcc tggccgcgga aggtcacccc
    20881 ggcagaacct ccgccagcgt ggccccttgg tcgaggaggt cggccaaggc ggcgtagtgg
    20941 cgttgccagt cgatcggcca tgcagggttc cagtccggat cgatggccac cagagcctgt
    21001 cggcgtactt cggcccgctt ctcgtccttg cccaggccgc cgggtttgcg gaggttggcc
    21061 agccactgac cgaccgcgac gtcctcgatc atcgcgtcct tgggcgccgc cagcgtgccg
    21121 tgttcggcgt agtaggcccg ggccgcggtg aggttcttcc agaaccgggc gtcggggacc
    21181 gaccagatca tgcccagttc attgaggagt tcgacgcgcc acgccttcag tgtcccggcg
    21241 gcgaagctgc gtcgttgttc gctgacccat gccccaacgg gtacgtctca ccggagtctt
    21301 cggcagcgtc ttcgccgtcg ctctcggtca tcccgatcgg gaccaccgcg tccaacggca
    21361 cctgcgcgtg gccgtactct cgacccattt acgcagggcg ttgtagccgg cgagccagac
    21421 ctgggagtcg ggccgtagga cgcgggtgcg caagaaagcg gcgatgacgt cggggttgcg
    21481 cggcagggaa aaccgcagca acggcacccc cttcttctcg tcctcctggt cctcgtcctg
    21541 ctcccggccg gcctcgccgc gcccggcccc cctctcttgg ccgccctcgc cctcctcggg
    21601 ggtgccggcg ccgaggtctt cgactgccgc cggctcctgg ccgccttcgc cggccgcctg
    21661 ctgctcctct tcctcctcgc gctggggatc gagagcgacc acggaggtgg ccttgccgcg
    21721 ggcaccgcga ctggccacga tcatgcgctc gacgatgcgc tcgtcgcggg cccgcaatcc
    21781 ctggagaacg gcgaccaggg gccggtagct ggcggaggcc atcatgtcct cggggtcctc
    21841 cccgggctgg gctgcaggaa gatcggcacg atcagccgcg cgaccttccc ctccccgggg
    21901 ttctgccgca ggccccggcc ggtgatctgc acgatctgca ccggcgagga gcgcgtatca
    21961 gcgaacacca cacctggacg ccgcgtttgc cgcggatgtc gacgccctcg cccaacacct
    22021 gacacgacgc caggacgctg aagtcggtga cccatccgtc ggcgtcgagg ccgtcggcga
    22081 accggtccag caccgtccgc cgatgctggg ccgagtgctc cccgcacagc cactccgccc
    22141 ccacccgctt cggatacacc gcggggtcgg tctcgtggag tccggccgcg gtctccggca
    22201 gcgcccgagc caagctcatc gcgtccaggg tgcgactgtg gaaggtcatc agactctgca
    22261 ccccacacgc atccgcgtgc ttgagcaggg cggcctgcag cgccgccagc cgccggccgc
    22321 gcacctcctc caccgacgca tccagcccgg gggtttcggg gtcgcggatc tccaggacgt
    22381 cgatctcgaa acgggcgagg atcctccact cgatgctctc caacagcccg agttcgtaca
    22441 ggaccgggcc gtacaaatcg acgtcatcca tcgaggcgac cagccgcccc tccaggaccc
    22501 ccgagccgtc cccaagtcac cggcagcgcc ctggcgaccc gatgtaccag ccgccttggg
    22561 agaggcttcc cacaggcgag gggtggcggt catgtacagc cgccgcaccg ccggaatccg
    22621 ctcctgatcg tgaaccgccg cccacgcctt cccaagtccc cggagctgcg gtgcgcctcg
    22681 ttgtctgccc cggccgccgt ccctgggtca tacgggtcat cgagtgccgc cgatcgatgg
    22741 atacggcggt cgggtccgat gcggccgtcg tccggctggg acacgttcct tgcgggcgta
    22801 ccggcggaca cgccccagca cgaagaggaa cccagtgtcg tggggttccg aacgccttgc
    22861 ccatagttca cctgggtggt tgcaggaagg accctcgacg tgtctgatcc agtcgtcctc
    22921 atcacgggag cgctcaccgg tatcggccgc gccaccgctt tggcttacgc ccgtcaaggc
    22981 gcgaaccttg tcgtctccgg ccgccacgag gacgtgggcg agcagtttgc cagggaactc
    23041 accgacctcg gtgccccgtg tcaacggccg tgtggtgctc cccgtaggcg gccagtagtt
    23101 ctccctgctg gcggccggtt aggagtcccc gctggcggcc agttatctcc ccgccagtgg
    23161 ttggtgtgga tcagctgaag ggcttcactc cctttccggt ggtggcctcg gtgaacctga
    23221 acgaatcacc ctgagtgacc gtgacgtgag catggtgaag tagccggtcg acggtcgcgg
    23281 tggccagggt cttgggcatg atctcgtcga atccggaggg gtgaaggttg ctggagacgg
    23341 cgatcgagcg tcgctcgtag gcggcgtcga ccaggcggta gaagccctcg gcggcgtcct
    23401 cggaaacggg cagcagtcca atgtcgtcga cgatgatcaa atccgagcgg acaatcttcg
    23461 ccagcgcccg ggcgatggag tcgtcggcgc ggtggcggcg gaccagggcg cccaggtcct
    23521 cgatggtgaa ccaggcaacg gtcaggccgg cttcgaccgc ggtctgcccg agagcctcgg
    23581 tgaagtgcga ctttcccgtg cccgagggtc cgcagatgca aaaattctcc cggcggccga
    23641 cccattccag gctcttcagg gcgtcctggg tgggcctggg tatggacgac ttgccctcgt
    23701 gccagtcgcc gaaggtcttg ccggtgggga agccggcccg cttgcggcgg gtgtggaggt
    23761 tggcccggtc gcgtccggcg gcctcctccg ccagcaggac gcggacgacc tcggcgggat
    23821 cccagcgttg ggccttcgcg gtggggatga tgtcggtcaa cgaccggcgg atgtgcggga
    23881 gtttgaggcg cttggtgagc tcgatggcct cggcgagcgg gtcgccgttg gtgccgggaa
    23941 cggtgcgaag aggggtggcc atcaggcgag gtcgctttcg tcgtactcgg aaagatcggg
    24001 agtgctcgtg gccggggcgc cgagggcgga ccaggcggag gtgccgggct gcagcgagtg
    24061 gtcctcgctg cggcggacgg gctcggccat gccgtggacg gcctggtagt cgaggatgga
    24121 gagcaggtcc ttgtcggcga agcgggcggt gaccgcggcg gtgccgagcg cgcggtcgac
    24181 ttccgctgcc gagtagagct ttgacagcgc gacggcctcg gccatcttcg ccttgacccg
    24241 gcgaaccccg gccgccccgg cctcgatcag ccaactcgcg gcacccgggc cgagctggag
    24301 gaacgcggcc tcctcggcgg acgtggcccg cggggtgcgg tccgttccct tgtcctcgcg
    24361 gggcgggtag tgggcgtcat ccaggaccgg cgagccgggc tcaccgcgcg ggtggcgggc
    24421 cacctcgatg gccgagccgt gctcgtcgac ggcggtgacg atcagctcgt cgccgtggaa
    24481 acgggcccag acccgggtgt cgatcagctc gtgcgggacc gagtaacgca ccgcgtcgac
    24541 cgagatcgtc gactcccagg tgacccggcg ggtggtgccg aacgccgcgg tgaacggact
    24601 gcgcggcagc gggtgcagcc gctgggcttc ctccgcgaga cgctcgacgg gtttgcgccg
    24661 agtcgccttg tggatgcggg agttgacctc ctcgcagaaa ctgcggcagg ccgcctccag
    24721 ctcgccgaag gtcctgtact cctcgcgcag attcacgtcc cggggcacca gatcggcctt
    24781 cgcgatcttc accgtggact ccgagccacc cttggtctcc gggtccgccg gcagacacgt
    24841 ccgtatcgtc gtgccgtagt gcctcgccac ctcgacgacc tccggattac ggatggcgat
    24901 cccggcgacg tgatcggtgg tgaccgtctt ctcgttgtcc gtgaggacgt aggccgggat
    24961 cccgccgatc cttcggaacg tggcgtccag acacgcggtg accgtcggca gcgtcttgtc
    25021 ccagatcggg atgacgacac ggaaacggga ccaggccagc catgcgcaga acagcgtggt
    25081 cttgcgcccc ttgatcaccg ggccgtcacc gaagtcgtac tgaagccaga gccccggttc
    25141 ggtcacccac ggccgataga cccgccgccg accggccctg aact
//
