LOCUS       NZ_JAPTYM010000001     22077 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8817085
            Orig. end                         :: 8839162
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22077
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="39"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22077
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22077
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12077](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12077
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            77..835
                     /gene="hypB"
                     /locus_tag="O1M07_RS38875"
                     /old_locus_tag="O1M07_38865"
     CDS             77..835
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_function="GO:0016530 - metallochaperone activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /GO_process="GO:0051604 - protein maturation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="hypB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570317.1"
                     /locus_tag="O1M07_RS38875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38865"
                     /product="hydrogenase nickel incorporation protein HypB"
                     /protein_id="WP_039629845.1"
                     /transl_table=11
                     /translation="MCRVLDLQQAVLAKNDACAHTLREELAGRGTAVVNLLSSPGSGKT
                     ALLERELTRARERGVPVAALTADLATENDAVRLARSGVPVKQVLTDGLCHLEAEMLGGH
                     LDGWLPAGTRLLFVENVGNLVCPASYDLGETLRVVLASVTEGEDKPLKYPTAFGLAHLV
                     LITKTDIAAAVDFDEAAFRANVERVNPGAEVVRTSVRAGEGVGVLLDRALAAREGGPAH
                     IPVMTRQSHHVHDASADRVGHRDTVGSSRS"
     misc_feature    complement(90..103)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            832..3333
                     /gene="hypF"
                     /locus_tag="O1M07_RS38880"
                     /old_locus_tag="O1M07_38870"
     CDS             832..3333
                     /EC_number="6.1.2.-"
                     /GO_function="GO:0003998 - acylphosphatase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016743 - carboxyl- or
                     carbamoyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hypF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570316.1"
                     /locus_tag="O1M07_RS38880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38870"
                     /product="carbamoyltransferase HypF"
                     /protein_id="WP_189865046.1"
                     /transl_table=11
                     /translation="MTVGRPGAGTAPAPSPEPSMSLDEGASPGTGEDSRTGAAGTVRRA
                     EAPGTAPARHRVVVRGIVQGVGFRPFVHGLATELGLAGHVSNTGEGVVAEVEGPPGALH
                     RFGARLRAEAPPLAVVEAVDGQDIAVTGGTGFAILPSRTGGPARTLVAPDAATCDACLA
                     ELTDPADRRYRHPFVTCTHCGPRFTIVRALPYDRAQTTMADFPMCPRCAAEYADPADRR
                     FHAQPVACHDCGPRLRLLAHGPDGPAGPPRPLPGDPVAGARRLLAEGAIVAVKGLGGYH
                     LVCDAQDDRAVAELRRRKARGDKPFALMVRQLADVEGLVEIGAEERALLTGPVRPIVLL
                     RRRPGGPAPGAPVLSDHVAPGCPDLGLMLPYTPLHHLLFGLPGDPQGPRLLVMTSGNVS
                     GDPLVTDDADALVRLAHLADAWLAHDRAIQVPCDDSVARISDGAPLYVRRSRGCAPYPV
                     PLPVSVRPALATGGDLKTVLCLGEGHRAWLSAHIGDMDDLATQLAFERAAEHLATLTGV
                     RPRLLATDRHPGYRTGQWAHRHTHGRPLVRVQHHHAHIASAMAEHGLDGRRPVIGVAFD
                     GTGYGDDGAVWGGEVLLADYAGYRRFAQLGYVPQPGGDSAVRRPYRMALAHLHAAGLPW
                     TPDLPPVTACPPDELQLLARQLERNLNCAPTSSMGRLFDAVSSLAGICHHAGYEAQAAA
                     ALEAAARAAGDDRGPGYTFGLRTGAPGDGGAALVADPAPVLAAVTEDVRAGAGPAPVAA
                     RFHAAVAGLVRRCCGLARERTGLSTVALTGGVFVNTLLAETAARMLRQDGFTVLRHRLV
                     PPNDGGLALGQLLVAARRRGA"
     gene            3374..3673
                     /locus_tag="O1M07_RS38885"
                     /old_locus_tag="O1M07_38875"
     CDS             3374..3673
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570315.1"
                     /locus_tag="O1M07_RS38885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38875"
                     /product="HypC/HybG/HupF family hydrogenase formation
                     chaperone"
                     /protein_id="WP_189865044.1"
                     /transl_table=11
                     /translation="MCLAVPGKVMEIEERDGTRMATVDFGGVVKEVCLEYVPDLVVGDY
                     AIVHVGFALQRLDEESARRTLELFEELGLLQEEFGDPWEAAAAQEAMQAQEARK"
     gene            3670..4794
                     /gene="hypD"
                     /locus_tag="O1M07_RS38890"
                     /old_locus_tag="O1M07_38880"
     CDS             3670..4794
                     /GO_function="GO:0016530 - metallochaperone activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hypD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380323.1"
                     /locus_tag="O1M07_RS38890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38880"
                     /product="hydrogenase formation protein HypD"
                     /protein_id="WP_189865042.1"
                     /transl_table=11
                     /translation="MKYLDEFQNPELARRLLGEIRATVTRPWALMEVCGGQTHTIIRHG
                     IDQLLPEEVELIHGPGCPVCVTPLAVIDQALEIAARPEVIFCSFGDMLRVPGTDRDLFR
                     VRGEGGDVRVVYSPLDALKIAQQNPHREVVFFGIGFETTAPPNAMTVYQARKLGIRNFS
                     MLVSHVRVPPAIEAIMTSSSCRVQGFLAAGHVCSVMGTDEYPSLADRFRVPIVVTGFEP
                     LDILEGIRRTVRQLERGEHTVDNAYPRAVRPEGNPAARAMLADVFEVTDRSWRGIGTIP
                     ASGWRLSDRYRDHDAEHRFSVGGITTREPAACRSGEVLQGLIKPHECEAFGTTCTPRTP
                     LGATMVSSEGACAAYYLYRRLGSTPTPLEATPVV"
     gene            4787..5893
                     /gene="hypE"
                     /locus_tag="O1M07_RS38895"
                     /old_locus_tag="O1M07_38885"
     CDS             4787..5893
                     /codon_start=1
                     /gene="hypE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570313.1"
                     /locus_tag="O1M07_RS38895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38885"
                     /product="hydrogenase expression/formation protein HypE"
                     /protein_id="WP_272492949.1"
                     /transl_table=11
                     /translation="MSDTTSQAPTTEQGPRDLPTVDITGWTCPAPLRETPRVVMGHGGG
                     GALSAELVQQIFVPAFGGELLAQLGDSAVFALGGQRLAFSTDSYVVRPLFFPGGCIGDL
                     AVNGTVNDLAMSGARAAYLSCGFILEEGVEMPVVAGVADAMGAAARAAGVEVATGDTKV
                     VEAGRGDGVYLNTAGIGVIPPGVDLRPQRVVPGDVVIVSGDIGVHGVAIMSVREGLEFG
                     VEIESDCAALGGLVQTMLAVTPELHVLRDPTRGGLAAALNEIATASATGVVIDERAVPV
                     PPAVANACAILGLDPMYVANEGKLVAFVPREHADAVLDAMRAHPLGAGAAVIGEAVAAH
                     PGMVVARTPLGGTRVVDLPLGEQLPRIC"
     gene            6072..7154
                     /locus_tag="O1M07_RS38900"
                     /old_locus_tag="O1M07_38890"
     CDS             6072..7154
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003984262.1"
                     /locus_tag="O1M07_RS38900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38890"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_189865040.1"
                     /transl_table=11
                     /translation="MSGLTIAVHHVRAALGGARRLGIDTAPLLQGAGIPPLLLADDRAR
                     VTAEQFTRLIRALHQATDDEFLGLGPVPSRRGTFAMMCHACLGCPDLGSALDRATRFYR
                     LFPGGPDLAVALRPDDGPAVLTVRSALHRHDEAAFLAACLLLIWHRLAGWLIGRRIPLH
                     WAQFAHPAPAHADEYPALFGCPVHFGAPYTAAGWDARWLTAPVVRDQPALAALLRRAPA
                     DLLGRRDYGTTVAEQVRRSLAQALRSPAPARLPEAGEIAARLAVSPATLRRRLRAEGTS
                     YQRLKDTVRRDAALTALTAGREPIAALAARIGFSEDTAFHRAFRRWTGTTPGAYRLAGA
                     TPRSGEAPPSGPPVPRGQQK"
     gene            7238..8407
                     /locus_tag="O1M07_RS38905"
                     /old_locus_tag="O1M07_38895"
     CDS             7238..8407
                     /GO_function="GO:0004806 - triglyceride lipase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016042 - lipid catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943691.1"
                     /locus_tag="O1M07_RS38905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38895"
                     /product="lipase family protein"
                     /protein_id="WP_189865038.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 4e-06, bitscore:
                     25.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRRATALGTAAALALSLGTVGAAAADPPRTTAGRPGDIVTATPA
                     AFHPLPGQPTGTRAWHLTYRSTSAKGTPNTVSGTVIVPDDGRTGPRPLVTYAVGTVGLG
                     DSCAPSAGFPKGTTMEANLIQQLTARGWAVAVTDYEGLGTPGDHTYTVGRAEGQAVLDA
                     ARAAERLPEAAAAGVTQDSPVGIMGYSQGGQATSWAAELHRTYAPELKVKGTATGGVPA
                     DLRKVADANNGNVGAGLILMAAIGQNAAFPELDLAKYLNDRGRRYVAFLRENCVVADVA
                     AGLFKRISDVTVRNPLDQPDWQARLRESTLGTRTPDAPVYLYHGTADELIPYAVGKRLR
                     ADWCARGARVRWTSIPLGEHVLGAIVGAAPAADWLADRFADRPAPDNCP"
     misc_feature    complement(8462..8476)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.94"
                     /tool="antismash"
     gene            <9023..9094
                     /gene="pqqA"
                     /locus_tag="O1M07_RS38910"
                     /old_locus_tag="O1M07_38900"
                     /pseudo=""
     CDS             <9023..9094
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_147995344.1"
                     /locus_tag="O1M07_RS38910"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38900"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /pseudo=""
                     /transl_table=11
                     /translation="WRTPGYTVVETGLEVTAYALNTR"
     gene            9105..10004
                     /gene="pqqB"
                     /locus_tag="O1M07_RS38915"
                     /old_locus_tag="O1M07_38905"
     CDS             9105..10004
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="O1M07_RS38915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38905"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_268934602.1"
                     /transl_table=11
                     /translation="MQLRVLGTAAGGGVPQWNCACPGCAGARAHPDRRRRHASLAVRAD
                     HDHWYLINATPDIADQIEHTPTLHPDPGARRTPVAGIVLTDAELDHTLGLARLREADRI
                     EVLATDPVRAALRERLRLDDVLTPYADVAWRELAAALAPLSAGSDIEISAVPVSAKRPR
                     YAAGSRTGATGPWVVALRLHDRRTGGTALYAPALADWPDALQAAVADADLVLLDGTFWD
                     DEEPRRSGFATRTATGMGHLPIDGPGGTARRLAPLAARCLYTHLNNTNPLVDPTAPQHQ
                     ELAARGLAVAAEGMEIAL"
     gene            10001..10681
                     /gene="pqqC"
                     /locus_tag="O1M07_RS38920"
                     /old_locus_tag="O1M07_38910"
     CDS             10001..10681
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056908.1"
                     /locus_tag="O1M07_RS38920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38910"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_189865033.1"
                     /sec_met_domain="TIGR02111 (E-value: 8.6e-82, bitscore:
                     273.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPFEERLRTVARDGYHDRHPFNLRMHAGELTPEELRRWIRNRF
                     HYQRHIPVKDALVLAKLGTPELRRMWLRRIQDHDGQRDGEGGIERWLRLGEAAGLDRAL
                     LGDGTGVLPGVRLAVDGYVNFCRLRSPLEAVAASLTELSAPDIMRTRIDAFEKHYRWIE
                     PEGLDYFRGRQDQGRRDGKEALALVLDWARTEAEQQLAVEALRFKCQVLWSLLDAVERG
                     ESRP"
     gene            10678..10935
                     /gene="pqqD"
                     /locus_tag="O1M07_RS38925"
                     /old_locus_tag="O1M07_38915"
     CDS             10678..10935
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433952.1"
                     /locus_tag="O1M07_RS38925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38915"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_308217108.1"
                     /sec_met_domain="PqqD_RRE (E-value: 7.4e-20, bitscore:
                     69.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-12, bitscore: 46.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGWRPALAPAVLLRHDRVRDTDLLLLPERVVVLEGSAGAVLRLC
                     DGEREVADIVAELSRRYPDAPVAAEVPAFLGRMRGEGWLR"
     aSDomain        10690..10929
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_O1M07_RS38925_PqqD_RRE.1"
                     /evalue="2.30E-22"
                     /identifier="RREFam006.1"
                     /label="O1M07_RS38925"
                     /locus_tag="O1M07_RS38925"
                     /protein_end="84"
                     /protein_start="4"
                     /score="69.5"
                     /tool="antismash"
                     /translation="RPALAPAVLLRHDRVRDTDLLLLPERVVVLEGSAGAVLRLCDGER
                     EVADIVAELSRRYPDAPVAAEVPAFLGRMRGEGWL"
     gene            10923..12077
                     /gene="pqqE"
                     /locus_tag="O1M07_RS38930"
                     /old_locus_tag="O1M07_38920"
     CDS             10923..12077
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433951.1"
                     /locus_tag="O1M07_RS38930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38920"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_372516431.1"
                     /sec_met_domain="PF04055 (E-value: 3.9e-22, bitscore: 78.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-05, bitscore: 23.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.6e-07, bitscore: 30.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.7e-09, bitscore:
                     35.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVSAPPGPAPRPEPPWALLAELTHGCPLHCTYCSNPLRLIAGS
                     AELTTVEWQDALRQAADLGVVSAHLSGGEPLLRSDLEAVVAAADHAGIHTQLVTSGVGL
                     GRERLRRLADAGLRSVQLSVQHAAAAASDRIAGRRSFAAKERAAELVRAAGLPLGVNVV
                     LHRHNLDALDALIDLAAAWRADRIELANTQFYGWALLNRAELLPSHEQLGRAAETVRRR
                     RTELAGTLDVVWVVPDLFDGNAKPCMGGWGAVSLTVAPDGTVLPCPAAASIAGLDAPNV
                     RDHRLAWIWNHSPAFTRYRGTAWMREPCRSCAMREKDFGGCRCQAFAFTGDAAATDPAC
                     RLSPDHGLVRELVEAAPRRDPGRLGRPRRPARRAPVTGGGAAAE"
     misc_feature    12145..12160
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.47"
                     /tool="antismash"
     gene            12300..13058
                     /locus_tag="O1M07_RS38935"
                     /old_locus_tag="O1M07_38925"
     CDS             12300..13058
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570310.1"
                     /locus_tag="O1M07_RS38935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38925"
                     /product="chitinase"
                     /protein_id="WP_189865027.1"
                     /transl_table=11
                     /translation="MRTRLAALLSATTMAVGLALVAPASPAVASAGCPSCVAPAGADTR
                     AEGFVVSEAQFNQMFPNRNPFYTYSGLVAALSSYPEFANTGSDTVKRQEAAAFLANVGH
                     ETGGLVYVVEQNTGNYPHYCDATQPYGCPAGQAAYYGRGPLQLSWNFNYKAAGDALGID
                     LLNNPYLVERDAAVAWRTALWYWNTQNGPGTMTAHNAMVTGAGFGETIRSINGSLECNG
                     GNPGQVQNRIDNYTRFAQILGTVPGDRLGC"
     misc_feature    12324..12326
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13089..14372)
                     /locus_tag="O1M07_RS38940"
                     /old_locus_tag="O1M07_38930"
     CDS             complement(13089..14372)
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537732.1"
                     /locus_tag="O1M07_RS38940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38930"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_189865025.1"
                     /transl_table=11
                     /translation="MRSERTGDEQGPAQDGGRRGFLKYAAGIAGVAAGAGLGGGTAVAV
                     PAGRTATDGSPAPSGDGRQLPPDRVPFHGRHQAGIITPQQLFAGFAAFDVLVQNRADLA
                     RLLQRLTDRSRVLSAGVKPRDERTASEPQTPDSLTVTVGLGASLFDDRFGLAGHKPRHL
                     KAMPSFPDDRLEPARCHGDLSVQVCAEHPDAIVHVLRDLSRATHGMLRPRWRMDAFMNP
                     SRPSGSPRNFLGFKDGIVNPDTGSAEELDDLIWVTPPCGEPDWAEGGSYQVLRLIRFHS
                     ESWDDVPVRRQEEIFGRHKASGAPLGGAVEGDAPNYRDDPDGRTIPLDSHIRLANPRTR
                     RTDRSRFLRRSYNYNQGYDRHGQMDLGLVFCGYQQNVQRQFATVQHRLRHEPLSRFITP
                     EGGGYFFVPPGVRDEEDWFGARLMRDTH"
     gene            14568..14801
                     /locus_tag="O1M07_RS38945"
                     /old_locus_tag="O1M07_38935"
     CDS             14568..14801
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571421.1"
                     /locus_tag="O1M07_RS38945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38935"
                     /product="acyl-CoA carboxylase subunit epsilon"
                     /protein_id="WP_229922075.1"
                     /transl_table=11
                     /translation="MTRPPEESAEVPLRIVRGRADPEELAALTVIVCSRLALARALAEG
                     QGDEARPDALTGPQLRNHQVRSACWAGCWVCG"
     gene            15069..15620
                     /locus_tag="O1M07_RS38950"
                     /old_locus_tag="O1M07_38940"
     CDS             15069..15620
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS38950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_38940"
                     /product="transcriptional regulator"
                     /protein_id="WP_268934603.1"
                     /transl_table=11
                     /translation="MPRGAGLDAAGGRHRYYRLAAPDVARALEQLALIARPLPVHSLND
                     GTRARALLRARLCYDHLAGRLGVALMAALLADGILREEGTEAAQAPVRYLLTPHGRGRL
                     TALGVELEHLPRRRSAVRYCVDWGERRHHLAGAVGGAVTARLFALDWLRNGRYRRVVRL
                     TDAGRRGLGETFGLTPEQLV"
     misc_feature    complement(15637..15654)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.97"
                     /tool="antismash"
     gene            15801..17357
                     /locus_tag="O1M07_RS38955"
                     /old_locus_tag="O1M07_38945"
     CDS             15801..17357
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537729.1"
                     /locus_tag="O1M07_RS38955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38945"
                     /product="APC family permease"
                     /protein_id="WP_229922078.1"
                     /transl_table=11
                     /translation="MRRDLGFWGLTGIGFSNIVGSGWLFAAMYAAQTAGPAALLSWIGA
                     GLLCGLVALVMIELGASRPEGGGTVRWPLFANGRLVGTVVGWSVLLSVGGTAAEISAIM
                     QYTAHYLPGLYNGHTLTLAGLALACGLSVLLTALNWFAVKLFARLNTLVSIFKIAVPIA
                     TVLALIASGWHSGRLTDHGGFAPYGYVACLTALAGGGIVYSVNGFQAPLDFSGETRKPR
                     RTLPWAVLAGIGLALLMYLALQVAYLFTVPEHLLGGGWKGVSFDSPFGQLALILNLHWL
                     SSLLYADAVLSPGGSAYVGVAIDARHTYALAKNGTIPRYFMKVDEGSGMPRRALVINLV
                     VIVLFLLPFGGWQDIVSVMGDMYLLIYAASAVAVAVFRTGPGGTAGWVPGLRWIAPLSF
                     VVASEFVYWSGWQHLRLALPLVLAGVLLFLWMRRPGAPVIEDDGAGPRRSLGAELRIGA
                     WLVVYLVGLTALSWLGTFKGSGHLPAPYDSLTVAAAALAVFFWAVRSGVGQLTAAPQPA
                     G"
     gene            17446..18279
                     /locus_tag="O1M07_RS38960"
                     /old_locus_tag="O1M07_38950"
     CDS             17446..18279
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571425.1"
                     /locus_tag="O1M07_RS38960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38950"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_189865023.1"
                     /transl_table=11
                     /translation="MLRRRPPRAASADDLLTTLGRLTAQAREGAELQRARVELAEVLQR
                     EMLPAALPELPGLRTAATYAPARHGLAIGGDWYDGFPLPDGSLAFSVGDVQGHDVEAAA
                     FMGQIRIGLRAVAAHAADPGEVLSRANDLLLSIDCELFATCTFVRFDPLSWELTSARAG
                     HVPGVWATIDRRWGVAEDPGGIPLGVLPGQRYPVTRRRLTAAGVFVLLTDGVIEGPSFP
                     IEAGLAEVARLVRAKAGDDPAEVAGAVMCVAELTGHTDDAAVIVLCHDAGRRGAG"
     gene            18343..19320
                     /locus_tag="O1M07_RS38965"
                     /old_locus_tag="O1M07_38955"
     CDS             18343..19320
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537727.1"
                     /locus_tag="O1M07_RS38965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38955"
                     /product="MASE1 domain-containing protein"
                     /protein_id="WP_189865081.1"
                     /transl_table=11
                     /translation="MVRTGEIRRLAPATLGNLVLAAVYYGAAKIGLLEQVVIAGAVVTP
                     LWPPTGIALSCLLLLGLRMWPGIALGTVLVIWTLTRPDLAGFGVVAGNTLAPVCACLML
                     RRVGFHTELDRLRDGVALVSLGAFAAMVISATLGSGTQVLTGSLPAGDFWRTWASWWVG
                     DAMGVLVITPLVLAFRTVRPFRDVPLYRWGEAAALLVTAVVVSLVATRTSLSVLFLVFP
                     VIVWAALRFQLIGAAPCVLLMSVFAISAATGRYGPFTGRSLLESMVNLQAFNASAALTA
                     LLLSAIVTEQNTIRRKIEQVCQELAEVVDRLAPGESRRRWPPER"
     gene            complement(19337..20398)
                     /locus_tag="O1M07_RS38970"
                     /old_locus_tag="O1M07_38960"
     CDS             complement(19337..20398)
                     /EC_number="6.5.1.1"
                     /GO_function="GO:0003910 - DNA ligase (ATP) activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092025.1"
                     /locus_tag="O1M07_RS38970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38960"
                     /product="ATP-dependent DNA ligase"
                     /protein_id="WP_189865021.1"
                     /transl_table=11
                     /translation="MDLPVMPPVSPMLAKSVANIPAGMQYEAKWDGFRVIVFRDGDEVE
                     IASRTTKSLSRYFPEVLAAARAELPPRCVLDGEIVIAHDGRLHFEELLERIHPADSRVR
                     TLAARTPASLVAFDLLALDSASLLDEPQTARREALVEAVRPARAPVHLAPATTDRELAQ
                     RWFAQFEGAGLDGVIAKPPDLPYRPGERVMYKVKHARTADCVVAGYRLHKSGPVVGSLL
                     LGLHDDAGHLQHVGVCASFPMARRRALVEELAPLRMDDAAGHPWAAWADEAAHAGRRMP
                     GGPSRWSGGKDLSWVPLRPERVCEVGYDHMEGSRFRHTAQFRHWRPDRTPESCTYAQLE
                     EPVGYDLGELLGG"
     gene            20503..21516
                     /gene="ligD"
                     /locus_tag="O1M07_RS38975"
                     /old_locus_tag="O1M07_38965"
     CDS             20503..21516
                     /EC_number="6.5.1.1"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578712.1"
                     /locus_tag="O1M07_RS38975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_38965"
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_174717843.1"
                     /transl_table=11
                     /translation="MAGARAVELDVAGRAVRVSNPDKTYYPARGFTKLDVAQYYLSVAD
                     GVLRGLRDRPTTMQRFPDGVEGEFFYQKRAPKGLPDWLPTARITFPSGRFADEMCPNEP
                     AAVVWAANLGCLTFHPWPVRRADTEHPDELRIDLDPQPGTGFADAVTVAHELRALLTEH
                     GLRGWPKTSGGRGVHVYVPIRPHWTFTEVRRAAIAVARTLERRLPTLVTSAWWKEERGE
                     KVFVDYNQMARDRTIASPYSLRARPRATVSTPLRWEELSAVEPEDFDLRTVPPRFAELG
                     DVHADMADHAFGLEALLELADRHAADEGLGDLPYPPDHPKMPGEPARVQPSRARKH"
     gene            21664..22032
                     /locus_tag="O1M07_RS38980"
                     /old_locus_tag="O1M07_38970"
     CDS             21664..22032
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS38980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_38970"
                     /product="hypothetical protein"
                     /protein_id="WP_189865019.1"
                     /transl_table=11
                     /translation="MSDFLPYQEQRMRKFIGRSLAVAVLTAATVVPTVGMAQAAPQGQT
                     VAVSGDHGRGHHGRNHRHRRDDDCDFVGFGKFDEEGRSGHEGREGHRGRGHYEREGCEF
                     HDIGLIGRILRGLLGWWF"
ORIGIN
        1 cgcgaactgc ggatcgccga cgtcagctgg cacgacgccc cggtacccac accgacgcac
       61 gaggagcgct gatcccatgt gccgtgtcct tgatctgcag caggcggtgc tcgccaagaa
      121 cgacgcctgt gcgcacaccc tgcgcgagga actggccggc cgcggcaccg cggtcgtcaa
      181 tctgctctcc agcccaggga gcggcaagac cgccctgctg gaacgggagt tgacgcgggc
      241 gcgggaacgc ggggtgccgg tcgcggcgct caccgccgac ctggccaccg agaacgacgc
      301 ggtgcggctg gcccgctccg gagtccccgt caaacaggtg ctcaccgacg ggctgtgcca
      361 cctggaggcc gagatgctcg gcgggcacct ggacggctgg ctccccgccg ggacccggct
      421 gctgttcgtc gagaacgtcg gcaacctcgt ctgccccgcc tcctacgacc tgggggagac
      481 cctgcgggtg gtgctggcct cggtgaccga gggcgaggac aagccgctga agtaccccac
      541 cgccttcggg ctggcccacc tggtcctgat caccaagacc gacatcgccg cggcggtgga
      601 cttcgacgag gcggcgttcc gggccaacgt ggaacgggtc aaccccggcg ccgaggtcgt
      661 ccgcacctcg gtgcgcgccg gtgagggcgt cggggtgctg ctggaccggg ccctggcggc
      721 gagggagggc gggccggcgc acattccggt gatgacccgt cagtcccacc atgtgcacga
      781 cgcgtcggcg gaccgggtcg gccaccgcga caccgtgggg tcgagccgct catgaccgtc
      841 gggcggcccg gtgccggcac cgctcccgca ccctcccccg aaccgtcgat gtccctcgac
      901 gagggggcgt ccccgggcac gggggaggac tcccgaacgg gagcggcggg caccgtgcgt
      961 cgtgccgagg cccccgggac cgcccccgcc cgccaccggg tcgtcgtacg cggcatcgtc
     1021 cagggcgtcg gcttccgccc gttcgtgcac ggcctcgcca ccgagctggg gctggccggt
     1081 catgtcagca acaccggcga gggagtcgtc gccgaggtcg agggcccgcc gggcgcgctg
     1141 caccggttcg gtgcgcggct gcgcgccgag gcgccgccgc tggcggtcgt ggaggcggtg
     1201 gacggccagg acatcgcggt caccggcggc accggcttcg ccatcctccc ctcccgcacc
     1261 ggtggcccgg cccgcaccct ggtcgcgccg gacgccgcca cctgtgacgc ctgcctggcc
     1321 gaactgaccg accccgccga ccgtcgctac cggcacccct tcgtcacctg cacgcactgc
     1381 gggccgcgct tcaccatcgt ccgcgcgctg ccctacgacc gggcgcagac cacgatggcc
     1441 gacttcccga tgtgcccgcg ctgcgcggcc gagtacgcgg acccggccga ccggcggttc
     1501 cacgcccagc cggtcgcctg ccatgactgc gggccccggc tgcggctgct ggcccacggc
     1561 ccggacgggc ccgccggccc gccgcgtccg ctgcccggcg acccggtggc cggcgcccgg
     1621 cggctgctcg ccgagggcgc gatcgtcgcc gtcaagggac tgggcggcta ccacctggtg
     1681 tgcgacgccc aggacgaccg cgcggtggcc gagctgcgca ggcggaaagc ccggggcgac
     1741 aagccatttg ccctgatggt ccgtcaactc gcggacgtgg aagggctggt ggagatcggt
     1801 gcggaggagc gggcgctgct caccgggccg gtgcggccga tcgtgctgct gcgccgtcgg
     1861 cccggcgggc ccgcgccggg ggccccggtg ctctccgacc acgtcgcccc cggctgcccc
     1921 gacctggggc tgatgctccc ctacaccccg ctgcaccacc tgctgttcgg cctgccgggc
     1981 gacccccagg gcccccggct gctggtgatg accagcggca acgtctccgg cgacccgctc
     2041 gtcacggacg acgcggacgc cctggtgcgc ctggcgcacc tggccgatgc ctggctggcc
     2101 cacgaccggg cgatccaggt cccgtgcgac gactcggtgg cccggatcag cgacggcgca
     2161 ccgctgtacg tccggcgctc gcgcggctgc gccccgtacc cggtgccgct gccggtgtcg
     2221 gtccggcccg cgctggccac cggcggcgac ctgaagaccg tgctgtgcct gggggagggg
     2281 caccgggcct ggctgtccgc gcacatcggc gacatggacg acctcgccac ccaactggcg
     2341 ttcgagaggg ccgccgagca cctggcgacc ctcaccgggg tccggccccg gctgctggcc
     2401 accgaccggc accccggcta ccgcaccggc cagtgggccc accggcacac ccacggtcgt
     2461 cccctggtcc gggtccagca ccaccacgcg cacatcgcct ccgccatggc cgaacacggc
     2521 ctggacggcc gccggccggt catcggcgtc gccttcgacg gcaccggcta cggcgacgac
     2581 ggtgcggtct ggggcggcga ggtcctcctc gccgactacg ccggataccg ccgcttcgcc
     2641 cagctcggct acgtcccgca gcccggcggc gacagtgccg tacgccggcc ctaccggatg
     2701 gccctggccc atctgcacgc cgcgggcctc ccctggaccc ccgacctgcc gccggtcacc
     2761 gcctgcccgc ccgacgaact tcagctgctg gcacgccagt tggagcgcaa tctcaactgc
     2821 gcgccgacct ccagcatggg ccggctcttc gacgcggtct cctcgctcgc cgggatctgc
     2881 caccacgccg gctacgaggc gcaggccgcc gccgcgctgg aggccgccgc ccgcgccgcc
     2941 ggcgacgacc gcggccccgg ctacaccttc gggctgcgca ccggcgcccc gggcgacgga
     3001 ggagcggcgc tggtcgccga ccccgccccc gtgctcgccg cggtcaccga ggacgtgcgg
     3061 gccggcgccg gcccggcgcc ggtcgcggcc cgcttccacg ccgcggtcgc cgggctggtc
     3121 cggcgctgct gcggactggc cagggagcgc accggcctgt cgaccgtggc gctgaccggc
     3181 ggggtgttcg tcaacaccct gctcgccgag accgccgccc ggatgctgcg ccaggacggt
     3241 ttcaccgtgc tgcggcaccg cctggtcccg cccaacgacg gcggactggc gctcggtcag
     3301 ctgctggtcg cggcccggcg gcgcggcgcc tagccccctg tatgtccccg cacccgtacg
     3361 acgaggagga gccatgtgcc tggcggtgcc cggcaaagtg atggagatcg aggaacggga
     3421 cggcacccgg atggccaccg tcgacttcgg cggggtggtc aaggaggtgt gcctggaata
     3481 cgtgccggac ctcgtggtcg gcgactacgc gatcgtccat gtgggcttcg cgctgcagcg
     3541 cctcgacgag gagtcggccc ggcggaccct ggagctcttc gaggaactcg gcctgctcca
     3601 ggaggagttc ggcgacccgt gggaagcggc ggccgcccag gaagcgatgc aggcacagga
     3661 ggcgcggaag tgaagtacct cgacgagttc cagaacccgg agctggcccg gcggctgctc
     3721 ggcgagatcc gcgccacggt gacccggccc tgggcgctga tggaggtctg cggcggccag
     3781 acgcacacca tcatccggca cggtatcgac caactcctcc ccgaagaggt cgagttgatc
     3841 cacgggccgg gctgcccggt gtgcgtcacc ccgctggcgg tcatcgacca ggcgctggag
     3901 atcgccgccc gccccgaggt gatcttctgc tcgttcggcg acatgctccg cgtcccgggc
     3961 accgaccgcg acctgttccg ggtgcgcggc gagggcggcg acgtccgcgt ggtctactcg
     4021 ccgctcgacg ccctgaagat cgcccagcag aacccgcacc gcgaggtggt gttcttcggc
     4081 atcggcttcg agaccaccgc cccgcccaat gccatgacgg tctatcaggc ccgcaaactg
     4141 ggcatccgca acttcagcat gctggtctcg cacgtccggg tgccgcccgc gatcgaggcg
     4201 atcatgacct cgtcgagctg ccgggtccag ggattcctgg ccgccggcca tgtgtgcagc
     4261 gtgatgggca ccgacgagta cccctcactg gccgaccgct tccgggtgcc gatcgtcgtc
     4321 accggcttcg aaccgctgga catcctggag ggcatccgcc gcaccgtccg ccagctggaa
     4381 cgcggcgagc acaccgtgga caacgcctat ccgcgcgccg tccgccccga aggcaacccg
     4441 gccgcgcggg ccatgctggc cgacgtcttc gaggtcaccg accgcagctg gcgcggcatc
     4501 ggtaccatcc ccgccagcgg ctggcggctc tccgaccgct accgcgacca cgacgccgaa
     4561 caccgcttct ctgtcggggg catcaccacc cgcgagcccg ccgcctgccg cagcggcgag
     4621 gtcctgcagg ggctgatcaa gccccacgag tgcgaggcgt tcggcaccac ctgcaccccg
     4681 cgcaccccgc tcggcgccac catggtctcc agcgagggcg cctgcgccgc ctactacctc
     4741 taccgccggc tcggcagcac gccgaccccc ttggaggcga cccccgttgt ctgacaccac
     4801 ctcgcaggcc cccaccaccg agcagggccc ccgcgacctg cccaccgtcg acatcaccgg
     4861 ctggacctgc cccgccccgc tgcgcgagac cccgcgcgtc gtgatggggc acggcggggg
     4921 cggggcgctc tccgccgaac tcgtccagca gatcttcgtg cccgccttcg gcggtgaact
     4981 cctcgcccag ctcggcgact ccgcggtctt cgcgctcggc ggacagcgcc tggccttctc
     5041 caccgactcc tacgtcgtcc gcccgctgtt cttccccggc ggctgcatcg gcgacctcgc
     5101 ggtcaacggc accgtcaacg acctcgccat gagcggcgcc cgggccgcct acctctcctg
     5161 cggtttcatc ctggaggagg gcgtggagat gccggtggtc gccggggtcg ccgacgcgat
     5221 gggcgccgcg gcccgggccg ccggcgtgga ggtggccacc ggcgacacca aggtcgtcga
     5281 ggccggccgc ggcgacgggg tctacctcaa caccgccggc atcggggtga tcccgcccgg
     5341 cgtcgatctg cggccgcagc gggtggtgcc cggcgacgtg gtgatcgtca gcggcgacat
     5401 cggcgtgcac ggcgtggcca tcatgagcgt ccgcgagggc ctggagttcg gcgtggagat
     5461 cgagagcgac tgcgcggccc tcggcgggct cgtccagacg atgctcgcgg tcacccccga
     5521 actgcacgtg ctgcgcgacc ccacccgagg tggactggcc gccgcgctca acgagatcgc
     5581 caccgcctcc gccaccggcg tggtcatcga cgagcgcgcc gtccccgtcc ccccggccgt
     5641 cgccaacgcc tgcgcgatcc tcggcctcga tccgatgtac gtcgccaacg agggcaagct
     5701 ggtggcgttc gtcccccgtg agcacgccga cgccgtgctg gacgcgatgc gcgcccaccc
     5761 cttgggcgcc ggcgccgcgg tgatcggtga ggcggtcgcc gcccaccccg gcatggtggt
     5821 ggcccgcacc ccgctcggcg gcacacgggt ggtggacctg cccctggggg agcagctgcc
     5881 gcggatctgc tgagccggcg gtcgcaccgg tcggcggggc cgcccgcacc ggccccgccg
     5941 accggccgcg tcacgaccgc tgacctctgc gcccgccacc gctacggtgc ggccatgagc
     6001 gagcggagcg agcgaatcat cgacaggtgc gcgccgggcg catgcgaggg cgggcggagc
     6061 gagctctcgg catgagcggg ttgacgatcg cggtgcacca cgtacgggcg gcgctgggcg
     6121 gggcgcggcg gctcgggatc gacaccgcgc cgctgctcca gggcgccggg atcccgccgc
     6181 tgctgctcgc cgacgaccgg gcccgggtca ccgcggaaca gttcacccgg ctgatccggg
     6241 ccctgcacca ggccaccgac gacgagttcc tgggcctggg cccggtcccc agccgccgcg
     6301 gcaccttcgc catgatgtgc cacgcctgcc tgggctgccc ggacctcggt tccgccctgg
     6361 accgggccac ccgcttctac cggctcttcc ccggcggccc cgacctggcc gtggcgctcc
     6421 gcccggacga cgggccggcc gtcctcaccg tccgcagcgc actgcaccgg cacgacgagg
     6481 ccgccttcct cgccgcctgc ctgctgctca tctggcaccg gctcgccggc tggctgatcg
     6541 ggcgtcggat cccgctgcac tgggcccagt tcgcccaccc ggcccccgcg cacgccgacg
     6601 agtacccggc cctgttcggc tgcccggtcc acttcggcgc cccgtacacc gcggccggct
     6661 gggacgcccg ctggctcacc gcgccggtcg tccgggacca gcccgcgctg gccgccctgc
     6721 tgcggcgggc cccggccgac ctgctgggcc gccgcgacta cggcaccacc gtcgccgagc
     6781 aggtgcgccg cagcctcgcc caggcgctgc ggtccccggc gccggcacgg ctgccggagg
     6841 ccggcgagat cgcggcccgg ctggcggtca gcccggcgac gctgcggcgc cggctgcgtg
     6901 ccgagggcac ctcttaccag cggctgaagg acacggtgcg ccgggacgcc gcgctcaccg
     6961 cgctgaccgc cgggcgggag ccgatcgccg cactcgcggc ccggatcggc ttctccgagg
     7021 acaccgcctt ccaccgcgcc ttccgccgct ggaccggcac cacccccggc gcctaccgac
     7081 tggccggcgc caccccgcgg tccggcgaag ccccgccgtc cggcccgccc gttccgcgcg
     7141 gccagcaaaa gtgagcgttc cggtcagcgc ccgcccccgc gcaggtcact acggtcggcc
     7201 caaccaccca ggcccacagg acagttggga gagccgcatg caccgtcgcg ccaccgccct
     7261 gggcaccgcc gcagcgctgg ccctgtcgct cggcaccgtc ggcgccgccg ccgcggaccc
     7321 gccacgcacc acggccggcc gccccggcga catcgtcacc gccacccccg ccgcgttcca
     7381 tccgctgccc ggccagccga ccggtacccg cgcctggcac ctcacctacc gctccacctc
     7441 cgccaagggc acccccaaca ccgtctccgg caccgtgatc gtgcccgacg acggccgcac
     7501 gggcccgcgc ccgctcgtca cctacgcggt cggcaccgtc ggcctcggcg actcctgcgc
     7561 cccctcggcc ggcttcccca agggcacgac catggaggcc aacctcatcc agcagctcac
     7621 cgcccgcggc tgggcggtcg cggtcaccga ctacgagggg ctgggcaccc ccggcgacca
     7681 cacctacacc gtcgggcgcg ccgaggggca ggccgtcctg gacgccgccc gggccgccga
     7741 gcggctcccc gaagcggccg ccgccggcgt cacccaggac tccccggtcg gcatcatggg
     7801 ctactcccag ggcggccagg ccaccagctg ggccgccgag ctgcaccgga cctacgcgcc
     7861 cgaactcaag gtcaagggca ccgcgaccgg cggcgtcccg gccgacctgc gcaaggtcgc
     7921 ggacgccaac aacggcaacg tcggcgccgg gctgatcctg atggccgcca tcggtcagaa
     7981 cgccgccttc cccgagctgg acctggcgaa gtacctcaac gaccggggcc ggcgctatgt
     8041 cgccttcctg cgcgagaact gcgtcgtcgc cgacgtcgcc gccgggctct tcaagaggat
     8101 ctccgacgtg accgtccgca acccgctgga ccagccggac tggcaggccc ggctgcgcga
     8161 gtccacgctc ggcacccgga ccccggacgc gcccgtgtac ctctaccacg gcaccgccga
     8221 cgagctgatc ccgtacgccg tcggcaagcg gctgcgcgcc gactggtgcg cccggggcgc
     8281 ccgcgtccgg tggacctcga taccgctcgg cgagcacgtg ctcggcgcga tcgtcggcgc
     8341 cgcgccggcc gccgactggc tcgccgaccg tttcgctgac cgaccggcac ccgacaactg
     8401 cccctgagca atgaggcatt gacagaacgg gcgagtgggc gcgacccagc gcaggtcggt
     8461 ccggaacacc tggtccgaac cgggcccgcc gcctccgttg tcgtccgcgt gggtggtggc
     8521 cggccacagg ggtgggctgg cggagcgttg gtcgccgggg cgtccggatg gctgtgtgag
     8581 gcgtccacag gtcggaccaa ttttccgcgc cgcccttgac cgtgccgacc cggctgagga
     8641 ttctgcaatc ggcacagcca caccggccac caccacgcac cgtggtcgac gatccggcaa
     8701 ccgccggcgc gcccggtgcc gttgacgcac cgaccgccct ctcccgttcc ctccattccc
     8761 ttgcggcgtt ccgcggcgct cggcagcggc gccgggccgg ccgccgccgc tcgtcacgcc
     8821 gcagccccgc ccgctgctcc cgtcccccgc ccgcaccgcc acaccggccc gcgacacccc
     8881 gccacgctcc cgaaggaagg ctggaaccgg catgaactcc gcaacgcacg aggtcagcga
     8941 gcagtccccc ggtacggtcg tggcgcccgc gcaaccgggc ccgcccgacc cggccgccgc
     9001 gccccccgcc ccctccgggg agtggcggac cccgggctac acggtcgtcg agaccggact
     9061 cgaagtcacc gcctatgcgc tgaacacccg ctgaccgggc cgccgtgcag ctgcgggtgc
     9121 tcggcaccgc ggcgggcggc ggcgtgcccc agtggaactg cgcgtgcccc gggtgcgccg
     9181 gggcacgcgc ccacccggac cggcgccgcc ggcacgcctc gctcgccgta cgagccgacc
     9241 acgaccactg gtacctgatc aacgccaccc ccgacatcgc cgaccagatc gagcacaccc
     9301 ccaccctgca cccggacccc ggcgcgcgcc gcaccccggt ggccggcatc gtgctcacgg
     9361 acgccgaact cgaccacacg ctgggcctgg cacggctccg cgaggccgac cggatcgagg
     9421 tgctcgccac cgatccggtc cgcgcggcgc tccgcgagcg gctgcgcctc gacgacgtcc
     9481 tgaccccgta cgccgacgtc gcctggcggg aactggccgc cgccctcgct ccgctgagcg
     9541 cgggatccga catcgagatc agcgccgttc cggtctccgc caagcggccc cggtacgccg
     9601 ccgggtcccg caccggcgcc accggcccgt gggtggtcgc gctccgcctg cacgaccggc
     9661 ggacgggcgg gaccgcgctc tacgcccccg ctctcgccga ctggccggac gcgctccagg
     9721 cggcggtggc cgacgccgac ctcgtcctgc tcgacggcac gttctgggac gacgaggagc
     9781 cgcgccgcag cggcttcgcc acccgcaccg cgaccggcat gggccacctg ccgatcgacg
     9841 gaccgggcgg caccgcgcgc cgactggcgc cgctcgccgc ccgctgcctc tacacccacc
     9901 tgaacaacac caacccactc gtcgatccca ccgcaccgca gcaccaggag ctggcggcgc
     9961 gggggctcgc ggtggccgcg gaaggcatgg agatcgccct atgagcacgc cgttcgagga
    10021 gcgtctgcgg accgtggcac gggacggcta ccacgaccga catcccttca acctccgtat
    10081 gcatgcgggg gagttgacgc ccgaggagct gcgccggtgg atccgcaacc ggttccacta
    10141 ccagcggcac atcccggtca aggacgccct cgtactggcg aagttgggca cgccggaact
    10201 gcgccggatg tggttgcggc gcatccagga ccacgacggg cagcgggacg gcgagggcgg
    10261 catcgagcgc tggctgcggc tcggcgaggc ggccgggctg gaccgggcgc tgctcgggga
    10321 cgggaccggc gtactgcccg gggtgcggct cgccgtcgac ggctacgtca acttctgccg
    10381 gctgcgctcg ccgctggagg cggtcgcggc ctccctcacc gaactgtccg ccccggacat
    10441 catgcgcacc cggatcgacg ccttcgagaa gcactaccgg tggattgaac ccgagggcct
    10501 cgactacttc cgcggccgac aggaccaggg gcggcgggac ggcaaggagg ccctggcgct
    10561 ggtgctggac tgggcgcgca ccgaggccga acagcaactg gcggtcgagg cgctgcggtt
    10621 caagtgccag gtgctctggt cgctgctgga cgcggtcgag cgcggggaga gccggccgtg
    10681 accggctggc ggccggccct cgcccccgcc gtgctgctgc gccacgaccg ggtgcgggac
    10741 accgatctgc tgctcctgcc ggaacgcgtc gtggtgctgg aggggagcgc gggtgccgtc
    10801 ctgcggctgt gcgacgggga acgcgaggtg gcggacatcg tcgccgagct gagccgccgg
    10861 taccccgacg cgccggtggc ggccgaggtg ccggcgttcc tcgggcggat gcgcggggag
    10921 gggtggctgc ggtgagcgcg ccgcccggac cggcgccgcg accggagccg ccctgggccc
    10981 tgctcgcgga gctcacccac ggctgcccac tgcactgcac ctactgctcc aatccgctcc
    11041 gactcatcgc aggatcagcc gagttgacga ccgtcgaatg gcaggacgcg ctgcggcagg
    11101 ccgccgacct gggggtggtg agcgcccatc tctccggtgg cgaaccgctg ctccgctccg
    11161 atctggaggc cgtcgtggcc gccgccgacc acgccggcat ccacacccag ctcgtcacca
    11221 gcggcgtcgg actgggccgg gagcgcctgc gcaggctggc cgacgccggt ctgcgcagcg
    11281 tgcagctgtc cgtgcagcac gccgccgcgg cggcgtccga ccggatcgcc gggcgccgct
    11341 ccttcgccgc caaggaacgg gccgctgagc tggtccgcgc cgccgggctg ccgctgggcg
    11401 tcaacgtcgt cctgcaccgc cacaacctcg atgcgctgga cgccctgatc gacctcgccg
    11461 cggcctggcg tgcggaccgc atcgaactcg ccaacaccca gttctacggc tgggcgctgc
    11521 tcaaccgtgc cgagctgctg ccctcccacg agcagctcgg ccgggcggcg gagaccgtac
    11581 gccgccgccg gacggaactc gccggcacgc tcgacgtggt gtgggtggtc ccggacctct
    11641 tcgacggaaa cgccaagccg tgcatggggg gttggggcgc ggtgtccctg accgtcgcgc
    11701 ccgacggaac ggtcctgccc tgcccggcgg ccgcctcgat cgccggcctc gacgccccca
    11761 acgtccgtga ccaccggctg gcgtggatct ggaaccactc gcccgccttc acccgctacc
    11821 ggggcacggc ctggatgcgc gagccctgcc gcagctgcgc gatgcgggag aaggacttcg
    11881 gcggctgccg ctgccaggcg ttcgcgttca ccggcgacgc cgccgccacc gaccccgcct
    11941 gccgtctctc cccggaccac ggcctcgtcc gggaactggt ggaggcggct ccccggcggg
    12001 acccgggacg gctcggccgc ccgcgcagac ccgcccggcg ggctccggtg accggcggag
    12061 gggccgcggc ggagtgagcc ggggcggacc gccggccgtc gccgcggtgg tatggacagg
    12121 ctcgcgcgac cgcccgtagg gtgacctggt ctagaccgcg gatcgcctcc ggtcgcagcc
    12181 gccgacctgc ctgctcacac gtcaacaagc cggtgctgca cggcacttgc cccccacagt
    12241 ggttgccccc cgccctcctc ttcgcccgcg gggcccgacc gcacgaagga gtcaccgtca
    12301 tgaggacccg cctcgccgcc ctgttaagcg ccaccaccat ggccgtgggc ctcgcgctcg
    12361 tcgcaccggc ctcgccggcg gtggcctcgg cgggctgccc ttcctgcgtc gccccggccg
    12421 gtgccgacac ccgagccgag ggattcgtcg tcagcgaggc gcagttcaac cagatgttcc
    12481 cgaaccggaa tccgttctac acctacagcg gactggtcgc cgcgctgagc tcctacccgg
    12541 agttcgcgaa caccgggagc gacaccgtca agcgccagga ggccgccgcc ttcctggcga
    12601 acgtcggcca cgagaccggg ggcctggtct acgtggtgga gcagaacacc ggcaactacc
    12661 cgcactactg cgacgccacc cagccgtacg ggtgtccggc cggccaggcc gcctactacg
    12721 gacgcggacc gctccagctc agctggaact tcaactacaa ggccgcgggc gacgcgttgg
    12781 gcatcgacct gctgaacaac ccgtacctgg tcgagcggga cgccgcggtc gcctggcgga
    12841 ccgcgctgtg gtactggaac acccagaacg gaccgggcac catgaccgcg cacaacgcca
    12901 tggtcaccgg cgccggcttc ggcgagacca tccgcagcat caacggctcg ctggagtgca
    12961 acggcggcaa ccccggccag gtgcagaacc ggatcgacaa ctacacgcgc ttcgcgcaga
    13021 tcctcggcac cgtgccgggc gaccgcctcg gctgctgacc gggccccgcc cccgggacac
    13081 ccgcctcgtc agtgggtgtc ccgcatcagt cgggcgccga accagtcctc ctcgtcccgc
    13141 accccgggcg gcacgaagaa gtagccgccg ccttccgggg tgatgaagcg ggacagcggc
    13201 tcgtgccgca gccggtgctg cacggtggcg aactgccgct gcacgttctg ctggtagccg
    13261 cagaagacca ggcccaggtc catctgcccg tgccggtcgt acccctggtt gtagttgtaa
    13321 ctccggcgca ggaaacggga cctgtcggtg cgtcgggtgc gcgggttggc cagtcggatg
    13381 tgcgagtcga gcgggatggt ccggccgtcg gggtcgtcgc ggtagttcgg cgcgtcgccc
    13441 tccaccgcgc cccccagcgg cgcgccgctc gccttgtgcc gtccgaagat ctcctcctgg
    13501 cgccgcaccg gcacgtcgtc ccaggactcg gagtggaagc ggatcagccg cagcacctga
    13561 tagctgccgc cctcggccca gtccggctcg ccgcacggcg gcgtcaccca gatcaggtcg
    13621 tccagctcct ccgccgaccc ggtgtcgggg ttgacgatgc cgtccttgaa gccgaggaag
    13681 ttccgcggcg accccgaggg ccgggacggg ttcatgaacg cgtccatccg ccagcgcggc
    13741 cggagcatgc cgtgggtcgc ccggctcagg tcgcgcagca cgtgcacgat cgcgtccggg
    13801 tgctccgcgc agacctggac cgagaggtcg ccgtggcagc gcgccggctc cagccggtcg
    13861 tcggggaagg acggcatcgc cttcaggtgc cgcggcttgt gcccggccaa cccgaaccgg
    13921 tcgtcgaaga gggacgcccc gaggccgacc gtgacggtca gcgagtccgg ggtctgcggc
    13981 tccgaggccg tccgctcgtc cctcggcttc accccggcgg acagcacccg ggaccggtcg
    14041 gtcagcctct gcagcagccg tgccaggtcc gcccggttct gcaccagcac gtcgaacgcc
    14101 gcgaacccgg cgaagagctg ctgcggggtg atgatgccgg cctggtggcg gccgtggaac
    14161 ggcacccggt ccggcggcag ctgacggccg tcgcccgacg gggcggggga gccgtccgtc
    14221 gccgtccggc ccgccgggac ggccaccgcc gtgccgccgc ccagcccggc gccggccgcc
    14281 accccggcga tccccgccgc gtacttgagg aacccccggc gcccgccgtc ctgcgccggg
    14341 ccctgctcgt cgccggtccg ctcagatctc atcgcccagc catccccact gcggcatccg
    14401 ccgccggtgt gcgtgcccct acttgcgcgc gatcctcgcc gcccgcccgg cggcgcccgg
    14461 gagcaacacg gccgggccca tcgaaatcac gcctgcggag gcggcccggc cgccgaacgg
    14521 cgcaggccgc cgggccgccg ccaccacccg ctcctagcgt cggcggtatg acccgtccgc
    14581 ccgaggagtc cgccgaggtg ccgctgcgca tcgtccgagg tcgcgccgat ccggaggagc
    14641 tggccgcgct caccgtcatc gtgtgcagtc ggctcgccct ggcccgcgcg ctcgccgagg
    14701 gccagggcga cgaggcccga cccgacgcgc tgaccggacc gcagttgcgc aaccaccagg
    14761 tccggtccgc gtgctgggcg ggctgctggg tctgtgggtg agcatcgggg ccacagcggt
    14821 gccctcgcgc gacgggcgcg acgtcccggg cgcggattcc gcccccccgg acgcgggtgt
    14881 gccgacgcgg atcacgggca ggcggtcgtc gggaacgacc gtgaggagca gccgtatgac
    14941 cttgccgtgg cgacaggacg agagctggcg ccgccgcgca acgtgttcct cccgttcgtc
    15001 gtcggggcgg tggtggtcgc ggtggcggcc gtcgggctga tcgccttcgg gtgagggcgg
    15061 cggggggggt gccccggggc gccggcctcg atgcagccgg cggccggcac cgctactacc
    15121 ggcttgccgc gcccgacgtc gcccgcgccc tggaacagct cgccctgatc gcccggccgc
    15181 tgccggtgca ctccttgaac gacggcaccc gcgcccgggc cctgctgcgc gcccgcctgt
    15241 gctacgacca tctggcgggc cgcctcggcg tcgcgctgat ggcggccctg ctggccgacg
    15301 gcatcctccg ggaggagggc accgaggcgg cccaggcgcc ggtccgctac ctcctgacgc
    15361 cccacggccg cggccgactg accgcgctcg gcgtggagtt ggagcacctg ccgcgccgcc
    15421 gctcggcggt ccgctactgc gtcgactggg gcgagcggcg ccaccacctc gccggcgcgg
    15481 tcggtggcgc ggtcaccgcc cgactgttcg cgctggactg gctgcgcaac ggtcggtacc
    15541 ggcgggtcgt ccggctcacc gacgccgggc gccgggggct cggcgagacc ttcggcctga
    15601 cccccgagca actcgtctga ccccgccgcc acacgcttca cactgccgca acattcggcc
    15661 tccctgtggc gcgaacatgt cgagtagggt cctgaccagc gcagatcgcg aggcgaggag
    15721 gccgttccgt ggcggaacgt caggtatcgg gcgagcccgg cgggggcgcc gggcccgaag
    15781 tgcgggcaca ggaacgccgg ttgcggcggg acctgggctt ctgggggctg accggcatcg
    15841 gcttctcgaa catcgtcggc tccggctggc tgttcgcggc catgtacgcc gcgcagaccg
    15901 ccggaccggc cgcgctgctg tcctggatcg gcgcgggcct gctgtgcgga ctggtcgccc
    15961 tggtcatgat cgagctgggg gcgtcccggc cggagggcgg cggcaccgtc cgctggccgc
    16021 tgttcgccaa cggccggctg gtcggcaccg tcgtcggctg gtcggtgctg ctgtcggtcg
    16081 gcgggaccgc cgccgagatc agcgcgatca tgcagtacac cgcgcactac ctccccggcc
    16141 tctacaacgg ccacaccctc accctcgccg ggctggccct ggcctgcggg ctgagcgtgc
    16201 tgttgaccgc cctgaactgg ttcgcggtca aactgttcgc ccggctcaac accctggtct
    16261 cgatcttcaa gatcgccgta ccgatcgcca ccgtgctcgc cctgatcgcc tccggctggc
    16321 actccgggcg cctgaccgac cacggcggat tcgccccgta cggctacgtc gcctgcctga
    16381 ccgcgctggc cggcggcggc atcgtctact ccgtcaacgg cttccaggcg ccgctggact
    16441 tctccggcga gacccgcaag ccccgccgca ccctcccctg ggccgtcctc gccggcatcg
    16501 gcctggccct gctgatgtac ctcgcgctcc aggtcgccta cctgttcacc gtccccgaac
    16561 acctcctcgg cggcggctgg aagggcgtct ccttcgactc ccccttcggt caactggccc
    16621 tgatcctcaa cctgcactgg ctctccagcc tgctctacgc cgacgcggtg ctctcgcccg
    16681 gcggttcggc ctacgtcggc gtggcgatcg acgcccggca cacctacgcg ctggccaaga
    16741 acggcaccat tccccgctac ttcatgaagg tcgacgaggg ttccggcatg ccgcgccggg
    16801 cactggtcat caacctcgtc gtcatcgtgc tgttcctgct gccgttcggc ggctggcagg
    16861 acatcgtcag cgtgatgggc gacatgtacc tgctgatcta cgccgcctcc gcggtcgccg
    16921 tcgcggtctt ccgcaccggg cccggcggca ccgccggctg ggtgccgggg ctgcgctgga
    16981 tcgccccgct gagcttcgtg gtggccagcg agttcgtcta ctggtcgggg tggcagcacc
    17041 tccggctggc gctgccgctg gtcctcgccg gagtgctgct cttcctgtgg atgcggcggc
    17101 ccggcgcacc ggtcatcgag gacgacggcg ccgggccgcg ccgctcgctg ggggccgaac
    17161 tccgcatcgg cgcctggctg gtggtctacc tcgtcgggct caccgcgctg tcctggctgg
    17221 gcaccttcaa gggctccggg cacctgcccg ccccctacga ctcgctcacc gtggccgccg
    17281 ccgcgctggc ggtcttcttc tgggcggtgc ggtccggcgt cggccagctg accgcggccc
    17341 cgcagccggc cggctgagcc cgtcgcgccc cggggccgcc accggggcgc ccgcggccgt
    17401 tcaggccgtc aagcggatgc cggacccccg aaatatgatg gggccatgct tcggcgtcgt
    17461 cccccgcggg cggcgagcgc cgacgatctg ctcaccacgc tcgggcggct gaccgcccag
    17521 gcgcgggaag gcgcggagct ccagcgggcc agagtggagc tggccgaggt gctgcagcgc
    17581 gagatgctgc cggccgccct tccggagctg cccggtctgc gcaccgccgc cacctacgcc
    17641 cccgcccggc acggcctcgc gatcgggggc gactggtacg acggattccc cctgcccgac
    17701 gggtcgctgg ccttctccgt cggcgacgtc cagggccatg acgtggaggc ggccgcgttc
    17761 atggggcaga tccggatcgg actgcgggcc gtcgccgcgc acgccgccga ccccggcgaa
    17821 gtcctcagcc gggccaacga cctgctcctg tccatcgact gcgagctctt cgcgacctgc
    17881 accttcgtcc ggttcgaccc gctgtcctgg gagctgacca gcgcccgcgc cggacacgtc
    17941 cccggcgtct gggccaccat cgaccgacga tggggcgtcg ccgaggaccc cggcggcatc
    18001 ccgctcggcg tgctgcccgg tcagcggtat ccggtcaccc gccggcggct caccgcggcg
    18061 ggtgtgttcg tgctgctcac cgacggggtg atcgaggggc cgtcgttccc catcgaggcc
    18121 gggctggcgg aggtggcccg gctggtcagg gccaaggccg gcgacgaccc ggccgaggtc
    18181 gccggcgcgg tgatgtgcgt cgccgagctg accggccaca ccgacgacgc cgcggtgatc
    18241 gtgttgtgcc acgacgcggg gcggcgcggg gccgggtgaa gcccggaccg gcagcgcgtg
    18301 tcgcgtccgg cggccgcccg ccggcattgt ctgatggcag atgtggtgcg caccggggaa
    18361 atccgtcggc tggctccggc caccctgggc aacctcgtgc tcgccgccgt ctactacggg
    18421 gccgcgaaga tcggcctgct ggagcaggtg gtgatcgcgg gcgccgtggt caccccgctg
    18481 tggccgccca ccggcatcgc cctgagctgc ctgctcctgc tgggcctgcg gatgtggccg
    18541 ggcatcgcgc tcggcaccgt cctggtgatc tggacgctca cccggccgga cctggccggc
    18601 ttcggtgtgg tggcgggcaa caccctcgcc ccggtctgcg cctgcctgat gctgcggcgg
    18661 gtcggcttcc acaccgaact ggaccggctg cgcgacggcg tcgccctggt ctccctcggc
    18721 gccttcgccg cgatggtgat cagcgcgacg ctgggcagcg gcacccaggt gctcaccgga
    18781 tcactgcccg ccggggactt ctggcggacc tgggcgtcct ggtgggtggg cgacgcgatg
    18841 ggcgtcctgg tgatcacccc gctggtgctc gccttccgga cggtccggcc gttccgcgac
    18901 gtccccctgt accggtgggg cgaggcggcg gcgctgctgg tgaccgcggt ggtggtctcg
    18961 ctggtggcca cccggacctc actgtccgtg ctgttcctgg tcttcccggt gatcgtgtgg
    19021 gcggcgctgc ggttccaact gatcggggcg gcgccctgcg tcctgctgat gtcggtcttc
    19081 gcgatcagcg cggcgaccgg ccggtacggc ccgttcaccg ggcggagcct gctggagtcg
    19141 atggtcaacc tccaggcgtt caacgcctcc gccgcgctca ccgcgctgct gctctcggcg
    19201 atcgtcaccg agcagaacac catccgccgg aagatcgagc aggtgtgtca ggagctcgcc
    19261 gaggtggtcg accggctggc accgggggag agccggcgcc gctggccgcc ggagcgctga
    19321 ccggccgccc gccgggtcag ccgccgagca gctcgcccag gtcgtagccg accggctcct
    19381 ccaactgcgc gtaggtgcag ctctccggag tacggtcggg acgccagtgg cggaactgcg
    19441 cggtgtgccg gaaccggctg ccctccatgt ggtcgtagcc cacctcgcac acccgctccg
    19501 ggcgcagcgg cacccacgac aggtccttgc caccgctcca acgactcggc ccgcccggca
    19561 tccggcggcc ggcgtgcgcc gcctcgtcgg cccacgcggc ccaggggtgc ccggcggcgt
    19621 cgtccatccg cagcggcgcc agctcctcga ccagggcgcg ccgccgggcc atggggaatg
    19681 acgcgcacac cccgacgtgc tggaggtgcc cggcgtcgtc gtgcagtccg agcagcagcg
    19741 agccgaccac cggcccgctc ttgtgcagcc ggtagcccgc gaccacgcag tcggcggtcc
    19801 gggcgtgctt gaccttgtac atcacccgct cgcccggccg gtacggcagg tccggcggtt
    19861 tggcgatcac cccgtccagc ccggccccct cgaactgcgc gaaccaccgc tgcgccagct
    19921 cccggtcggt ggtggcgggc gcgaggtgca ccggcgccct ggccggccgc accgcctcga
    19981 ccagggcttc ccggcgggcg gtctgcggtt cgtccagcag cgaagcggag tccagcgcca
    20041 gcaggtcgaa ggcgaccagc gaggcgggcg tgcgggcggc cagcgtccgc acccgggaat
    20101 cggccgggtg gatgcgctcc agcagttcct cgaagtgcag ccggccgtcg tgcgcgatga
    20161 cgatctcgcc gtccagcacg cagcgcggcg ggagttcggc ccgcgccgcg gccagcacct
    20221 cggggaagta gcggctgagc gacttggtgg tgcggctggc gatctcgacc tcgtcgccgt
    20281 cccggaacac gatgacgcgg aagccgtccc acttggcctc gtactgcatg ccggcgggga
    20341 tgttcgccac cgacttggcg agcatggggg agaccggggg catcacgggc aggtccatgc
    20401 cctcgatcct gcgggccggc gcccgttccc gcccgccggg accggccgcc ccgccgcgcc
    20461 gcccaccgcg cggggtcccc cggcggaccc tagcgtggag tcatggccgg agcccgagct
    20521 gtggaactgg acgtcgcggg gcgtgcggtg cgcgtgtcga acccggacaa gacgtactac
    20581 ccggcgcgcg gattcaccaa gttggacgtc gcccagtact acctgtccgt ggcggacggg
    20641 gtgctgcgcg gcctgcggga ccggccgacg accatgcagc ggttccccga cggcgtcgag
    20701 ggcgagttct tctaccagaa gcgggcaccc aaggggctgc cggactggct gccgaccgcc
    20761 cgcatcacct tccccagtgg caggttcgcg gacgagatgt gtccgaacga acccgccgcc
    20821 gtggtctggg cggccaacct ggggtgcctg accttccacc cctggccggt ccgccgggcg
    20881 gacaccgaac accccgacga gctgcggatc gacctcgacc cgcagcccgg caccggcttc
    20941 gccgacgccg tcaccgtcgc ccacgagctg cgcgcgctgc tgaccgagca cgggttgcgc
    21001 ggctggccga agacctccgg cggccgcggg gtgcacgtct atgtaccgat ccgcccgcac
    21061 tggacgttca ccgaggtcag acgcgccgcg atcgccgtgg cacggacgct ggaacggcgg
    21121 ctgcccacgc tggtgacctc ggcctggtgg aaggaggagc gcggcgagaa ggtgttcgtc
    21181 gactacaacc agatggcccg cgaccgcacc atcgcctcgc cctattcgct gcgcgcccgg
    21241 ccccgggcga cggtctccac cccgctgcgc tgggaggagc tgtccgccgt cgagccggag
    21301 gacttcgacc tgcgcaccgt cccgccccgg ttcgccgaac tcggcgatgt ccacgcggac
    21361 atggccgacc acgccttcgg cctggaggcc ctgctggagc tcgccgaccg gcatgccgcc
    21421 gacgaggggt tgggcgacct gccgtatccg ccggaccacc cgaagatgcc cggcgagccc
    21481 gccagggtcc agcccagcag ggcccgcaag cactgacccg accggccgcg gaacgcaccg
    21541 ccgcgcggtg ccggcccggg cccggtcgtc ccggcggtac ccgttcagcc gcaatccgcg
    21601 ggctgttgga gtggccgtcc gctgcgcctg cgaggaacgc ggtaccgcgc ggtaccgatc
    21661 accttgtccg atttcctgcc atatcaggag cagcgcatgc gtaagttcat aggacgttcc
    21721 ctggccgtcg cggtgctcac cgccgcgacg gtcgtcccga cagtcggtat ggcccaggct
    21781 gcccctcagg ggcagaccgt cgcggtgagc ggggatcacg gccgtggtca tcacggtcgc
    21841 aaccaccgtc accgccggga cgacgactgt gacttcgtcg gcttcggcaa attcgacgaa
    21901 gaggggcgat ccggtcacga gggccgtgag ggccatcgcg gccgcggcca ctatgagcgg
    21961 gaaggctgcg agttccacga tatcgggctc atcggacgca ttctccgtgg cctgttgggt
    22021 tggtggttct gaccgtgcgc agccgggcgg gccgccgcag acacgtgctg cggcggc
//
