LOCUS       NZ_JAPTYM010000001     22535 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7745942
            Orig. end                         :: 7768477
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22535
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="32"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22535
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12535](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12535
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(209..222)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.17"
                     /tool="antismash"
     gene            318..776
                     /locus_tag="O1M07_RS33815"
                     /old_locus_tag="O1M07_33805"
     CDS             318..776
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS33815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_33805"
                     /product="hypothetical protein"
                     /protein_id="WP_189863763.1"
                     /transl_table=11
                     /translation="MAGPGRVPFRDRGRDAHEHRRTPPVRPVVVRPRRPESDPPRPYTP
                     LWRRLREDEWPPLGEVLRGRREQMSPGVLLVLLLPCLWWLTVPLMVGFASGPALRHAFN
                     LSALRAALPALVTTALVWVFAFLGRSAGGLPPARRRSRSARSSVARCR"
     gene            1207..1974
                     /locus_tag="O1M07_RS33820"
                     /old_locus_tag="O1M07_33810"
     CDS             1207..1974
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (13-169). E-value: 2.3e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_O1M07_RS33820_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045908.1"
                     /locus_tag="O1M07_RS33820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33810"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_189863766.1"
                     /sec_met_domain="adh_short (E-value: 8e-31, bitscore:
                     106.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGMNSTAPQSSRVIAITGAGTGIGRATARAFATEGAHVIAIGRR
                     IAPLKETAAGHHRITPLAADITAESGPERIVRAVLETHGRLDVLVNNAGIVRSGALGTL
                     TPEIIAPQLATNLIAPILLSQAALPLLETARGVIVNVSTSVGQRAWPGSSVYAATKTAL
                     ELLTRSWAVELAPRGIRVVAVAPGAIDTPIGEHQGLTPERMAAVREWQLAHTPLGRIGR
                     PEEAAWAITRLAAPAASFITGVVLPVDGGAVVA"
     aSDomain        1246..1713
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1M07_RS33820_PKS_KR.1"
                     /evalue="2.30E-10"
                     /label="O1M07_RS33820_PKS_KR.1"
                     /locus_tag="O1M07_RS33820"
                     /protein_end="169"
                     /protein_start="13"
                     /score="32.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VIAITGAGTGIGRATARAFATEGAHVIAIGRRIAPLKETAAGHHR
                     ITPLAADITAESGPERIVRAVLETHGRLDVLVNNAGIVRSGALGTLTPEIIAPQLATNL
                     IAPILLSQAALPLLETARGVIVNVSTSVGQRAWPGSSVYAATKTALELLTRS"
     CDS_motif       1255..1341
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O1M07_RS33820_0001"
                     /evalue="4.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="O1M07_RS33820"
                     /protein_end="45"
                     /protein_start="16"
                     /score="13.0"
                     /tool="antismash"
                     /translation="ITGAGTGIGRATARAFATEGAHVIAIGRR"
     CDS_motif       1702..1752
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O1M07_RS33820_0002"
                     /evalue="9.70E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="O1M07_RS33820"
                     /protein_end="182"
                     /protein_start="165"
                     /score="-1.0"
                     /tool="antismash"
                     /translation="LTRSWAVELAPRGIRVV"
     gene            2001..2372
                     /locus_tag="O1M07_RS33825"
                     /old_locus_tag="O1M07_33815"
     CDS             2001..2372
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010035147.1"
                     /locus_tag="O1M07_RS33825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33815"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_195826933.1"
                     /transl_table=11
                     /translation="MQIGELAKVTGTTARALRHYEQAGLISSERASNGYRVYEEGAAVR
                     VRNIRYLLAAGLTLDDVRVFLPCLDGDVAAAPPSDKGLRVAWERLAVLNERIAAQTETR
                     DRLEAALRQKTGGLIRPAA"
     gene            complement(2447..2623)
                     /locus_tag="O1M07_RS33830"
                     /old_locus_tag="O1M07_33820"
     CDS             complement(2447..2623)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS33830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_33820"
                     /product="hypothetical protein"
                     /protein_id="WP_189863768.1"
                     /transl_table=11
                     /translation="MAWTGRPPGVAVMFGKQLPKDHDLPSFVKLQVNRITTAATGKNPD
                     AQEASSAPSTPTT"
     misc_feature    complement(2635..2650)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.14"
                     /tool="antismash"
     gene            complement(2678..3160)
                     /locus_tag="O1M07_RS33835"
                     /old_locus_tag="O1M07_33825"
     CDS             complement(2678..3160)
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012974.5"
                     /locus_tag="O1M07_RS33835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33825"
                     /product="DnaB-like helicase N-terminal domain-containing
                     protein"
                     /protein_id="WP_189863770.1"
                     /transl_table=11
                     /translation="MTTLTAMPTPPDREATQRARVGRMLVAPDSIPETAATLLPEDLSG
                     PLAVVYVSVLAVYASGQPVDSITVGVHLHCRGRLAEVGGSTYLTALAQAGTSTVSLAAL
                     PAFHRPAEVVPLRTPTACRTSPPSKELLWDKVIAEFTSAALSTTSTASTSSYMPAT"
     gene            3478..3978
                     /locus_tag="O1M07_RS33840"
                     /old_locus_tag="O1M07_33830"
     CDS             3478..3978
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566773.1"
                     /locus_tag="O1M07_RS33840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33830"
                     /product="hypothetical protein"
                     /protein_id="WP_189863772.1"
                     /transl_table=11
                     /translation="MPLDDQHAWELLRALDDPDHMEFPRGYDHTAARARFDRLATRLDQ
                     RFQCTCTVDREVQDASHHGTIVIPDAATASGEHLTVTISNFGNLATLALGNPRSHDEEE
                     EEEREPCQNTDRHRVDEELEALGYLPISEHLLGTRYDGVSDLVSYFPAEHSPTWRTRFF
                     DYL"
     gene            complement(4415..5095)
                     /locus_tag="O1M07_RS33845"
                     /old_locus_tag="O1M07_33835"
     CDS             complement(4415..5095)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515283.1"
                     /locus_tag="O1M07_RS33845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33835"
                     /product="L,D-transpeptidase"
                     /protein_id="WP_189863911.1"
                     /transl_table=11
                     /translation="MGVALFAVLFAVSPDGNGPPLPDRLADTGGGSQLITAVAPRTGAT
                     TGTLTWWDRRGGEWVVAGSAPARFGAKGLVEGRKRRQGTNTTPTGLYDLPYGFGIKAAP
                     SGTATPYRRVNRNSWWCQDDRSRAYNRWAEPLPADCRAAESEHLADYGTQYAHALVIGF
                     NYKKPVRGRGAGIFLHVNGRAATAGCVSAPADAVRRILAWAKPRQRPHIAIGTTSGPTA
                     ITRY"
     gene            complement(5599..6441)
                     /locus_tag="O1M07_RS33850"
                     /old_locus_tag="O1M07_33840"
     CDS             complement(5599..6441)
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572105.1"
                     /locus_tag="O1M07_RS33850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33840"
                     /product="serine hydrolase"
                     /protein_id="WP_189863774.1"
                     /transl_table=11
                     /translation="MRALSSILVAAAPASAAPVSSNGRTAPHVVCTSDKPGLADRLTQD
                     ISTLVSSRYTKGHTSIALYDRTTKTSCTYDADRRHDSASVVKVIVLGALPRQVQDEHRD
                     LTGAERALATKMITRSDNDATTVLWKKLGLGRIKEFLHLAGMKHTVPDPDGYWGLAQIN
                     ASDQLTLMALFTATNSVLDDAYRAYALDLLNRVIPAQRWGVPAGAPSGARVHVKNGWLQ
                     RTGGGWRVHSVGAFTGHGHDYGLVVLTSDHADMAASVNKARPMPTSGLSWSATHFSGP"
     gene            6943..7131
                     /locus_tag="O1M07_RS33855"
     CDS             6943..7131
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS33855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268934584.1"
                     /transl_table=11
                     /translation="MWYALVGTGLHYVTDLMAEATGTKPSDVETARLALDALGFPIVCW
                     AWGDLLTTGHPGHRIRR"
     gene            7273..7908
                     /locus_tag="O1M07_RS33860"
                     /old_locus_tag="O1M07_33850"
     CDS             7273..7908
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471229.1"
                     /locus_tag="O1M07_RS33860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33850"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_229921980.1"
                     /sec_met_domain="HAD_2 (E-value: 1.4e-09, bitscore: 37.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVLTEGVRDAQHSWCVSEGLAPDAWRITLADLPEGRELYAALES
                     GRLSQAEWNRRTAPLLGVGDHHNLMGRAWSGVRPAVNMIALARAARRAGYTVAMLSNSF
                     GLDPYDPYEALGVWKLFDVTVISEQEGIAKPDPEIYQRTLERMGLPGEVCVFVDDNPGN
                     LPPAAALGITTVHADGQAGTVERLSSLLGLLPADGRVPGGAALEPEEF"
     gene            complement(8173..9159)
                     /locus_tag="O1M07_RS33865"
                     /old_locus_tag="O1M07_33855"
     CDS             complement(8173..9159)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049074.1"
                     /locus_tag="O1M07_RS33865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33855"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_189863780.1"
                     /transl_table=11
                     /translation="MDTEALRSFVRAAELGQFQHAADELGVTQQAVSKRIATLERELEV
                     RLFTRTARGVELTLDGQAFLSHARSIVAGVERAINAVRPGSRALRIDVLGLRSAQAVVL
                     HDYWRSRPEADLDVVTLRANDPRVVVAAVEAGDIDASFRTLIAPAALPPDLQMIHAFDS
                     PLELLVGPRHPLASARRLTPPQLRKHRIWVPGIAPRSEWAEFYDQLATHFDLRIDATGP
                     HFGDEVLLDTLADSADVATLVGTRDRYMWPTNHDLRRIPIVNPTLAYPLSLILPRTNPH
                     PELRRIITHLGTLPRLPDVVWRPSWATTPQRGENDIENAQRSRPRPR"
     gene            9812..9961
                     /locus_tag="O1M07_RS33870"
                     /old_locus_tag="O1M07_33860"
     CDS             9812..9961
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF039305.4"
                     /locus_tag="O1M07_RS33870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33860"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_107080297.1"
                     /transl_table=11
                     /translation="MQGNELQETDKLQTYEAPKMIECGSFQEDTGYFGLTGYENLFHFY
                     DKLH"
     CDS_motif       9812..9904
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MQGNELQETDKLQTYEAPKMIECGSFQEDTG"
                     /locus_tag="O1M07_RS33870_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9905..9961
                     /prepeptide="core"
                     /locus_tag="O1M07_RS33870_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="2.20"
                     /molecular_weight="2246.5"
                     /monoisotopic_mass="2245.1"
                     /core_sequence="YFGLTGYENLFHFYDKLH"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MQGNELQETDKLQTYEAPKMIECGSFQEDTG"
                     /leader_location="[9811:9904](+)"
     gene            10001..11821
                     /locus_tag="O1M07_RS33875"
                     /old_locus_tag="O1M07_33865"
     CDS             10001..11821
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="O1M07_RS33875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33865"
                     /product="asparagine synthase"
                     /protein_id="WP_189863782.1"
                     /sec_met_domain="Asn_synthase (E-value: 4e-41, bitscore:
                     140.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADAGWQYFVALPDDEGAAAAIGRFPTDGVRVLLRHRSGRPCVAG
                     RLAEDRVLVAERGDTRLAVIGHCSATRDELATAADRIDEVTDLDRLGLAWAGSYHLVAS
                     VRGQLRVQGTASGLRRIFHGELGTLTIAADRADVLATVLDAPLDPALLALRTLDVLPHP
                     LGDLPPWRNVSAVPPGWYLALPQDGRRPRVERWWQAPEPVRSLAAGGQLLRQALEDAVR
                     LRARGTRPISADLSGGMDSTSIALLAVRHRPSLTALTMENEDRADEDAQWARQAAAGLP
                     DLHHIVYSSRELPRFFGGLTAVEGVPDEPSTAVLSAPRLRAVRQRALAHGSRLHLDGLG
                     GDQLLCGHPAYHHDLLRHRPLLAAQRLRVLTQLRRSNWGTEARGLLDGHSYRRWFTDRA
                     HGRARRTPSPLSAWGHFPGLPAWLTPDARDLVTRTLRDTAATVEPLASTRGRHNDLLAI
                     QDAGRMVRQCHQLTETGDFSHTSPFLDDRVIQACLAVRPEQRVTPWEFKPLIKAAMADV
                     MPPEVLTRRTKGDGTTIVAEGFEAHRRELAELWDDSRLAALGLIDPGPLRELFELPYTN
                     SLHQGAMQSALSCELWARATAFQSAAATRP"
     aSDomain        11853..12104
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_O1M07_RS33880_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.40E-26"
                     /identifier="RREFam002.1"
                     /label="O1M07_RS33880"
                     /locus_tag="O1M07_RS33880"
                     /protein_end="84"
                     /protein_start="0"
                     /score="82.6"
                     /tool="antismash"
                     /translation="MTWRLHPDVSTVDTDYGTVLLNGGDGRYWQLNATASLAFRALVDG
                     STVQETTERLMASFDVDEPRARADVEQLMASLQQAKVVQ"
     gene            11853..12113
                     /locus_tag="O1M07_RS33880"
                     /old_locus_tag="O1M07_33870"
     CDS             11853..12113
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004949363.1"
                     /locus_tag="O1M07_RS33880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33870"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_189863784.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 7.5e-24,
                     bitscore: 82.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.3e-14, bitscore: 50.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWRLHPDVSTVDTDYGTVLLNGGDGRYWQLNATASLAFRALVDG
                     STVQETTERLMASFDVDEPRARADVEQLMASLQQAKVVQQA"
     gene            12110..12535
                     /locus_tag="O1M07_RS33885"
                     /old_locus_tag="O1M07_33875"
     CDS             12110..12535
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004949361.1"
                     /locus_tag="O1M07_RS33885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33875"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_189863786.1"
                     /sec_met_domain="PF13471 (E-value: 2.4e-26, bitscore: 91.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVVPHRTEVRLSPGRRLLVLLAVAVARRLAAKPPARTRAILTR
                     LRRGARAATYAEARAARDAVVAVSLRCAGDEGCLPRSLATVLLCRARGTWPTWTVGVRA
                     RLPFGAHAWVEAEGRMVEEKADPSYFRPLFSVPAEGA"
     gene            <12617..>12907
                     /locus_tag="O1M07_RS33890"
                     /old_locus_tag="O1M07_33880"
                     /pseudo=""
     CDS             12617..>12907
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386450.1"
                     /locus_tag="O1M07_RS33890"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="O1M07_33880"
                     /product="methyltransferase domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTVVDVGCGTGYYLAGVLDQLPDPRGLGLDASVRALRSAARAHRR
                     AAAASWDVFRPFPLVDQAADVVLDVFAPRNPSEFHRVLRPSGRLIVVRPTER"
     tRNA            complement(13094..13167)
                     /anticodon=(pos:complement(7759073..7759075),aa:Met,
                     seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="O1M07_RS33895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="O1M07_33885"
                     /product="tRNA-Met"
     gene            complement(13094..13167)
                     /locus_tag="O1M07_RS33895"
                     /old_locus_tag="O1M07_33885"
     gene            13318..15018
                     /locus_tag="O1M07_RS33900"
                     /old_locus_tag="O1M07_33890"
     CDS             13318..15018
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019888075.1"
                     /locus_tag="O1M07_RS33900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33890"
                     /product="protein kinase"
                     /protein_id="WP_372516400.1"
                     /sec_met_domain="Pkinase (E-value: 1.6e-47, bitscore:
                     161.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDGGASGDELMGKVLGGRYRVTATIGRGGMGVVARAVDQLLNRE
                     VAVKVLRAFTDASAPELVDLRTRMQREAQAAARIRHSGVVTVHDVTEEQGLPVIVMELV
                     DGPSLDDVLTERGTLEPHEAAAIGAKLMDALDAAHRVGVLHRDVKPANVLLEHGGRVVL
                     TDFGIATMDASGDEAMAKLTQSGQLVGSLDYLPPERAQGTVPSPASDIWSLGMTLYAAV
                     EGTSPFRRTSVWSTLSAIVTEPLPEPRRAGPLTPVLQALMAKDPKNRPTAEQAREMLQW
                     AAAGRTMNLAPPAPVAPAAPPVQAAGPTPPQAAATPVPPGSGAVPPFHPSSPQPPYTGY
                     PPSGPPPVTQPCMPTAGHAHGAGPATGRGRRSRRTLIAAAAAFVVLAGGGVTYALTAQH
                     GAVDGDRPQAAPGAGSPVGNGRPSGGGTADGINSPGSSPSTESGKPSGATSPSSAPPSA
                     EPSAAPSTSASPSAKPGSGPTTCSGWSHHDPKPGMYGYLSGDHHILTGPYQVCSSVAAT
                     KSGTKVWFHCSVENAYGHKWLYVRIGGTKNAGWMSADTVIRQSGWPVRC"
     gene            complement(15092..15628)
                     /locus_tag="O1M07_RS33905"
                     /old_locus_tag="O1M07_33895"
     CDS             complement(15092..15628)
                     /GO_function="GO:0004089 - carbonate dehydratase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952967.1"
                     /locus_tag="O1M07_RS33905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33895"
                     /product="carbonic anhydrase"
                     /protein_id="WP_272596069.1"
                     /transl_table=11
                     /translation="MALFITCSDSRVVPTMFTGARPGELFELRVAGNVVPRYRPQADCG
                     VAATLEYAVTALHVPDIVVCSHSHCAAVQGLMNPRQLTFLPLLEKWLSLSGHGTRATGE
                     PPSARTARVTRPDRPDPDTVAQLHTLIQLGNIRSYPFAAMRIAAGKLRLHGWLYAVETG
                     QVYVERPGSCRFQPL"
     misc_feature    complement(15545..15547)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15739..16653)
                     /locus_tag="O1M07_RS33910"
                     /old_locus_tag="O1M07_33900"
     CDS             complement(15739..16653)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018565288.1"
                     /locus_tag="O1M07_RS33910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33900"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_189863792.1"
                     /transl_table=11
                     /translation="MELTQRILQQVVVLAEEQHFGRAAERLAMRQPPLSQAIQRLERGL
                     GVTLFDRLPRGARLTPAGRAFAEDARRLLEAQAAAVDRARRIASGHEGELRLGFISSLG
                     YDFLPRLLRRTHAQLPALRLHLGQHPSAELVDMLQAGTLDLALVRLPVTGTDRLTVRRI
                     GVERLVAALPEHHPLAAKSRLDLRELAEEQFATPKPGALPGLAEQVALACAQAGFTPRS
                     RGQADDLPGLLSYVAAGLCLALAPEQVRTLGIPGVVYRPLHGDSPYLETAVAAVHRADG
                     PDAAVQQVLKLIEPRPPTVECAP"
     misc_feature    16648..16660
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            16775..17956
                     /locus_tag="O1M07_RS33915"
                     /old_locus_tag="O1M07_33905"
     CDS             16775..17956
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571523.1"
                     /locus_tag="O1M07_RS33915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33905"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_189863794.1"
                     /transl_table=11
                     /translation="MSTGREADGGVGPLNGVRVVELASVIMGPYAAQQLGDLGADVIKV
                     EPPTGDLTRHYPPTRSPGMGVMTLNLNRNKRSVALDLKAPGGRDALLALLASADVFLTN
                     VRPQALRRLDLAYEDVAAVNPGLVYLNAQGFRSDSPLGGHAAYDDVVQAASGLVWLNEQ
                     VSGVPHYVPTVLADKICGLVIVQSVLAALHHRDRTGQGQHVEVPMADTMLAFNLVEHLA
                     AATLNPPAGPIGYPRALSPRRTASRTADGWMCILPYSDRNWRDFFAFVGRPELADDPRF
                     ASYAARVHNADELYVLVGEFTTRHTNAQWQEFCDATSIPAAPVLSLTEAATSAYATEGG
                     LLQEAEHPTEGGYRLIGQPVRFWATPAGLHRHCPRVGEHTEEVLAEIGHRPPA"
     gene            18006..18869
                     /locus_tag="O1M07_RS33920"
                     /old_locus_tag="O1M07_33910"
     CDS             18006..18869
                     /NRPS_PKS="Domain: ECH (36-275). E-value: 1.4e-60. Score:
                     196.6. Matches aSDomain:
                     nrpspksdomains_O1M07_RS33920_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571524.1"
                     /locus_tag="O1M07_RS33920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33910"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_229921981.1"
                     /transl_table=11
                     /translation="MNEQARLDEQAPLDEQAPLDEQAAPNEWEPLRVEHRPNGVAVLTF
                     DNPDKRNPMTGRLTAQWRRAMRSLRQDPDLRAVVITGTGPAFCSGADLGELADRHGQSL
                     PGTRAQLSDFYRTWLTVRDLSVPTVAAVNGHAVGAGLALALACDLRYAAVEAKLGAPFV
                     RLGLHPGMATTALLAEAVGPSRARELLLTGRLISGARAATIGMVHEALPSDQVLRAALD
                     VADEIAAAAPLAVRLTKSGLAQGQPTVERALTWEGLAQPVTTTTDDFREGVQARRERRR
                     PHFTGA"
     aSDomain        18114..18830
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1M07_RS33920_ECH.1"
                     /evalue="1.40E-60"
                     /label="O1M07_RS33920_ECH.1"
                     /locus_tag="O1M07_RS33920"
                     /protein_end="275"
                     /protein_start="36"
                     /score="196.6"
                     /tool="antismash"
                     /translation="PNGVAVLTFDNPDKRNPMTGRLTAQWRRAMRSLRQDPDLRAVVIT
                     GTGPAFCSGADLGELADRHGQSLPGTRAQLSDFYRTWLTVRDLSVPTVAAVNGHAVGAG
                     LALALACDLRYAAVEAKLGAPFVRLGLHPGMATTALLAEAVGPSRARELLLTGRLISGA
                     RAATIGMVHEALPSDQVLRAALDVADEIAAAAPLAVRLTKSGLAQGQPTVERALTWEGL
                     AQPVTTTTDDFREGVQA"
     misc_feature    18951..18968
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            18995..20161
                     /locus_tag="O1M07_RS33925"
                     /old_locus_tag="O1M07_33915"
     CDS             18995..20161
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571525.1"
                     /locus_tag="O1M07_RS33925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33915"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_189863796.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.8e-22, bitscore:
                     78.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.4e-19, bitscore:
                     67.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.1e-07, bitscore:
                     31.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSVLDPGAVQLPPEAARLRQEVRDFLAAERAAGTVLGRPDSWL
                     TGWDPAFTRRLARRGWIGMTLPPEYGGGGRSNLERHVVIEELLAAGAPVSAHWVADRQA
                     GPSILRHGTEAQRSHFLPRIAAGACFFSIGMSEQDSGSDLASVRTRAERTAHGWRLTGT
                     KMWTGGAHVNDHAIVLARTDDSEDRHAGLSQFIVDLRDPHVRVEPIRLLSGEHTFNYCH
                     LEGVELTDDALLGRPGDGWRQVTGELALERSGPERFLSTLPLLSALVRQLQRTGGCGPE
                     QQARVGRLTARLSSIRQLSLGVAAALAAGRPADVQAALVKDLGTRFEGELVNEVREILP
                     IAARFDATRGSYPELLATAILHAPGYTLRGGTNEILRGIITRGLELSR"
     misc_feature    19052..19054
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20158..21165
                     /locus_tag="O1M07_RS33930"
                     /old_locus_tag="O1M07_33920"
     CDS             20158..21165
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.5"
                     /locus_tag="O1M07_RS33930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33920"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_189863798.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-13, bitscore:
                     50.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIESRAESAAEPRSERAAEALPPLDTAPTALVALAREAGYRGTP
                     APLAETLLVARPLLAAAGLAVPDGQLTMAAGPLDVRFTHVDTDSRVGPSGAAGTDDALR
                     VSGTLHRVPWARAVQAAVVLTEGPGGGPVLFLLEATEWRQLAGTNLAGEPRDDLVLLDV
                     AVPAERVRRVPAALVREAAWRSGLARAALIAGAARRCVELTVDHTSARVQFGRPLSHFQ
                     AVKQEEAKLVEEAALVAAAVEAAASALSEPDSAEFTAWLAAAQAAASVAEITRIAHQLH
                     GAIGFTELSPLRLATTRMWSWRDEDGGERAWQQRIGRHVLDGGSGGLWQQVTGG"
     gene            complement(21266..21778)
                     /locus_tag="O1M07_RS33935"
                     /old_locus_tag="O1M07_33925"
     CDS             complement(21266..21778)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538119.1"
                     /locus_tag="O1M07_RS33935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33925"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_189863800.1"
                     /transl_table=11
                     /translation="MLELAILGFLAEGPLHGYQLRHRIAHLSGHARPVSDGSLYPAINR
                     LVRAGLLDRRTEPGTSAAQRHTLSLTDTGRRELLRRLRDADGLDITDSTRYFTVLAFLS
                     RLPDTTDQHAVLRRRLEFLEQPASFFHDGDRPLRADDTDDPYRRGMLTIARATSRAERS
                     WLREVLA"
     gene            21834..22499
                     /locus_tag="O1M07_RS33940"
                     /old_locus_tag="O1M07_33930"
     CDS             21834..22499
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974516.1"
                     /locus_tag="O1M07_RS33940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33930"
                     /product="cysteine hydrolase family protein"
                     /protein_id="WP_189863802.1"
                     /transl_table=11
                     /translation="MTYTEEWVTARARHAYEHGQASFDLRPERTALLVIDMQDEFVRPG
                     WSPYWVPAATRMAPRLRRLVEDCRDASVPVIWTIFDDTHLGLDRPHALRFLPHADTDWR
                     RPGPAEVWGRMGRRPDEVVIRKPSYGAFYDTPLDTVLRNLGRDTVVVTGTLTNYCCGTT
                     ARQAYERGYRVVFGSDVTATDDESRQEPELAVLRKGFALVLTAEEITDRLTAAGRLRP"
ORIGIN
        1 cgggcccgga cgaaggccag atggtcctcg cggctgatcg ccgtcaggcg aaagctcatg
       61 cgtactcctc tgctcgacgc accagcctac cgaggcacac ggcactttca ggtctttcgt
      121 acacatgctg tcgtcgtgca cgaagcagcc gccgactgcc cggcaagaac gcacatcatg
      181 cccatcgcag gtgtcgcgaa cccgatgctt catgaacatg cagagcgtcg tccaaaacat
      241 gcggagcgtc gtacaacacg gtggcggctc tgccgctccg gctgtttccc ggcagcacgg
      301 ggcgtccgtc cggaaccgtg gccgggccgg ggcgcgtccc cttccgggac cgtggaaggg
      361 acgcccatga gcatcgacgc accccgcccg tccgaccggt cgtcgtacgg ccgcggcggc
      421 ccgagagcga cccgccgcgg ccgtacacgc cgctgtggcg acggctgcgt gaggacgaat
      481 ggccaccgct gggcgaggtg ttgcgggggc ggcgggagca gatgtccccc ggggtgttgc
      541 tggtgctgct cctcccgtgc ctgtggtggc tgaccgtgcc actgatggtc ggcttcgcct
      601 ccggtccggc gctgcgccat gccttcaacc tgtccgccct gcgcgcggcg ctgcccgcgc
      661 tggtcaccac cgccctggtc tgggtgttcg ccttcctcgg ccggtcggcg ggcggcctgc
      721 cgccggcccg gcgccgctcg cggtctgcgc gttcctcggt ggcccggtgt cggtgacggc
      781 ggtgtcctgg tgggagatcc accggctgcg gcggcgacac ggggtgcggt ggcggcccta
      841 gggcctgtcc gatgggtcat ggccgggtcc gcggcgtctg gtacggcacc tcgccgcgtt
      901 gccgaaacgc ccccatagct ccgctatcga gccgctccgg cgccttgcga tgcaccgcac
      961 cagacgccac ggccttgccg accctgaccc atcggacagg ccctagggcc tgtccgatgg
     1021 gttcagcgtc agggcgaagc cgagccgcgt cgggccgctc ttgtcggtca gcagcgcccg
     1081 gtcgcggccc ggatgtcggt cttcgacgtc gacgactacg gagtcaccga ggcagccggt
     1141 gaaccgttga ccgccggtcg cacgaggaca gctgcttgac cttgccgctg gcggcagggt
     1201 tgaacgatga ccggcatgaa cagcaccgca ccacagagca gcagggtcat cgccatcacc
     1261 ggggccggca ccgggatcgg ccgggccacc gcccgcgcct tcgccaccga gggcgcccat
     1321 gtgatcgcga tcggacgacg catcgcaccg ctgaaggaga ccgccgccgg gcaccaccgg
     1381 atcacgcccc tggccgccga tatcaccgcc gagagcgggc ccgagcgcat cgtccgagcc
     1441 gtactggaga cacatggccg actggacgtg ctggtcaaca acgccggcat cgtgcgcagc
     1501 ggcgccctcg gcacgctgac gccggagatc atcgcgcctc agctcgccac caacctcatc
     1561 gcccccatcc tgctgtccca agccgcgcta ccgctcctgg agacggcgcg cggggtgatc
     1621 gtcaacgtca gtacgtcggt ggggcagcgg gcctggcccg gcagctcggt ctacgccgcg
     1681 accaagaccg ccttggaact gctgacccgc agctgggcgg tcgagctggc accccgcggt
     1741 atccgggtcg tggccgtcgc cccgggcgcg atcgacaccc ccatcggcga acatcagggc
     1801 ctgacgccgg agcgcatggc cgcagtgcgg gaatggcagc tggcacacac tccgctgggt
     1861 cggatcggcc gccccgagga ggcggcctgg gcgatcaccc ggctcgctgc accggcggca
     1921 tcgttcatca ccggagtcgt actcccggtc gacggtggag cggtcgtggc gtgataggag
     1981 tggctcggga ggtggggcgg gtgcagatcg gcgagctggc caaggtgacc gggacgaccg
     2041 cgcgtgcgct acggcactac gagcaggcgg ggttgatctc ctccgagcgg gcctcgaatg
     2101 gctaccgcgt gtacgaggag ggggcagcgg tgcgggtgcg caacatccgc tatctgctgg
     2161 ccgccggact caccctggac gatgtgcgcg tgttcctgcc gtgcctggac ggcgatgtgg
     2221 ctgccgcacc gccgtcggac aagggcctgc gggtcgcatg ggaacggctg gcagtcctca
     2281 acgagcggat cgccgcccag accgagaccc gcgaccggct ggaagcggca cttcggcaga
     2341 agaccggcgg cctgatccgc ccggcggcct gaccggctgt cacagcgcgg aggccaagga
     2401 actccggcgc gcgaggcgac ggtcccgaag ggagagaacc gcggcctcac gtggtcggtg
     2461 tcgatggagc ggaggacgct tcctgggcgt ccgggttctt gcctgtggcg gcggtggtga
     2521 tgcggttgac ctggagcttg acgaaggacg gcagatcgtg gtccttgggc agctgcttgc
     2581 cgaacatcac ggccacgccc ggcggccggc ccgtccaagc cacgggcgga ggagtgttcg
     2641 ctcccggccc acggggcagg gagcgaacgg atctcgccta cgtcgccggc atgtacgagg
     2701 aggtcgaggc ggtgcttgtc gtcgagagtg ccgcgctggt gaactcggcg atcaccttgt
     2761 cccacagcag ctccttggac ggcggtgaag tgcggcaggc cgtgggcgtg cgcaggggga
     2821 ccacctccgc tggccgatgg aacgcgggca atgccgccaa cgagactgtg ctcgtaccgg
     2881 cttgggcgag cgcagtgagg taggtgctcc cgccgacttc ggcgagccgt ccccggcagt
     2941 gcagatgcac gcccacagtg atcgagtcga ccggctgccc ggaggcgtac accgccagca
     3001 ccgagacgta gacaacggcg agcgggccgg acaggtcctc cggcagcagg gtggcagccg
     3061 tctccgggat cgaatcgggg gcgacgagca tccggccgac ccgggcgcgc tgcgtggctt
     3121 ccctgtccgg cggagtgggc atggcggtga gtgtggtcat ggtcctgctc ctccggagct
     3181 tgatgcggtc ggcgaaggcc acccccgcca tgaacaacga gcaaaggggt gccacggaaa
     3241 ccatcggaac ctgcccgtgg gcacggcaac ctgtctgcag gcatggcaac ctgtccgcgg
     3301 cgcgtgaccg agcgcatcga ccggcggtcg ttcccggact cggagggggc ctcggacgct
     3361 ccgtccaagt cgccgtcctg tggaagacgg catccggcgg cgacgtcgac cgggccgccc
     3421 acgccgcaga tgtcaggcgg cgctccaacc ctgcccgcca gcaaggagaa gatgtacatg
     3481 cctctcgacg accagcacgc atgggaactg ctgcgagcac tcgatgatcc cgaccacatg
     3541 gaattccctc gtggctatga ccacacggct gcccgggccc ggttcgaccg cctcgcaacc
     3601 cgtctggacc agcggttcca gtgcacctgc accgtcgacc gtgaggttca ggacgccagc
     3661 caccacggga cgatcgtcat cccagatgcc gctacggcca gcggggaaca cctcaccgtg
     3721 accatcagca acttcggaaa cctcgccacc ctggccctgg gcaatcccag aagccacgac
     3781 gaggaagagg aagaggaacg tgagccctgc cagaacacgg accgtcatcg cgtcgatgaa
     3841 gagctcgaag cactcggcta cctccccatc tcggaacatc tgctcgggac gcgatacgac
     3901 ggcgtcagtg acctcgtctc ctacttcccg gccgagcatt ccccgacgtg gcggactcgc
     3961 ttcttcgact atctgtgact atctgtgacc ctcgtccgcg gtgtgctcgg gcagggcatt
     4021 cggacagttt ccccacccga ttccccaccc gaccccactg tgaggccgct cccaggccga
     4081 cgtgctcgac gtcctcgacc tggaaacggg cctcgccctg gcagacaccc tcaaccgggc
     4141 cggtgaacgc atcgccgccg gccagcaggt caccggcccc gcccacaagc cgaatcccgt
     4201 gccacactcg ccaccgaaca ggccgcggcc gcgctggccg cgctggagac cgtgccggtc
     4261 caggccggac tgctgcgggc cgccgcggtg ccgctggaag aacgggcccg catcagcgag
     4321 gaccaggccg aacgtgcggc cgcggggacc acggcggcat cgccgcgccg cacgcccgac
     4381 gccgccaccg cgatgcccct gcggagccct cgttctagta acgggtgatc gcggtgggtc
     4441 cggaggtggt cccgatcgcg atgtgtggcc gctgccgggg cttggcccag gccaggatcc
     4501 ggcgcacggc gtccgcgggc gcggagacac aaccggccgt cgccgcccgc ccgttgacgt
     4561 gcaggaagat gcccgcgccc cggccgcgta ccggcttctt gtagttgaag ccgatgacga
     4621 gcgcgtgcgc gtactgggtg ccgtagtcgg cgaggtgctc ggactcggcg gcgcggcagt
     4681 cggcgggcag cggctcggcc cagcggttgt aggcgcgcga gcgatcgtcc tggcaccacc
     4741 aggagttccg gttcacccgg cggtacggcg tcgcggtccc gctcggcgcg gccttgatcc
     4801 cgaagccgta gggaaggtcg tacagaccgg tgggggtggt gttggtgccc tgtctgcgct
     4861 tgcggccctc gacaagcccc ttcgccccga agcgggcggg cgcgctgccg gccacgaccc
     4921 actcgccgcc ccgccggtcc caccaggtca gcgtccccgt cgtggcgccg gtgcggggtg
     4981 cgacggcggt gatcagctga ctgcccccgc cggtgtcggc cagccggtcc ggcaggggcg
     5041 gaccgttgcc gtccggggac acggcgaaca ggacggcaaa gagcgcgaca ccgatacgta
     5101 cgacggccac ggaaaccccc gaagagagag ggacggttgc tcagaagcta cccggcggca
     5161 gcggaagagg gagcccgggc aggccgtcga cgtgtcgatc atgcgggctg tcggctgttc
     5221 gacggcctgg tcgttgctgt tggcctgccg caacgcttcg ggcacgccct ggccgtggcc
     5281 caccgaccgg cgccggcggg agcgatacgc gggctgaggg ccgcgacgcc gagcgtgcgg
     5341 tcgccgggac cacggctacg gcgagccgga gcgttgctcg gtttctacgg atcgccgttg
     5401 tgggcgagcg tctgggcctc accttggcag ccgcccgcgc ccgcgcccgc gcccgcgact
     5461 ccagcgatcc tgagccggtc gcggtcgccg ctcagatcgt tgaaagtgag gagcggccct
     5521 ccccttcctg ttcgtccagc ttcaagtccc ccttcgggcc ctcgaatacg cgcatatcag
     5581 cgggctgtga tcgcacgatc agggcccgct gaagtgcgtg gcactccagc tcaagcccga
     5641 agtcggcata gggcgggcct tgttcacgct ggcggccatg tcggcgtggt ctgaagtcag
     5701 caccacgagc ccgtagtcat ggccgtgtcc ggtgaaggcg ccaacgctgt gtacccgcca
     5761 gccaccaccg gtgcgctgaa gccagccgtt cttcacgtgg accctggctc cactcggcgc
     5821 gccggccggt acaccccagc gctgagcggg gatcacccgg ttcaacaggt ccagcgcgta
     5881 ggcccggtag gcgtcgtcga ggacggagtt cgtggcggtg aacagcgcca tcagcgtgag
     5941 ctggtcggag gcgttgatct gggccagccc ccagtatccg tccgggtcgg ggacggtgtg
     6001 cttcatgcct gcgaggtgca ggaactcctt gatgcggccg agaccgagct ttttccacaa
     6061 gacggtggtc gcgtcattgt ccgacctcgt gatcattttt gtcgcgagag cgcgctcggc
     6121 cccggtcagg tcacggtgct cgtcctggac ctggcgcggc agcgcgccca gcacgatgac
     6181 cttgacgacg ctggccgagt cgtgtcgtcg gtcggcgtcg tacgtgcaac tggtcttcgt
     6241 ggtgcggtcg tacaaggcga tcgaggtgtg ccccttcgtg taccgggagc tcaccagggt
     6301 gctgatgtcc tgggtgagcc ggtcggcgag accgggcttg tcggaggtgc acacgacatg
     6361 gggtgctgtc cggccgttcg aggagacggg ggccgcgctc gctggtgcgg cagccacgag
     6421 gatcgaagag agcgcgcgca tcaaaccgga ggtcggccaa gtcgccgagt gttgtaccga
     6481 tggggcctcg ggcgcgtcga tccgtttcat ggaacgcttc gtgtgcacgg ccccctgcag
     6541 tcggcggaag caccgaacgt cgcatcgggc cggtgtgatt ccgggtcccg cacggcggtc
     6601 ggccacttcc ctcagggcaa acgatgtcgt agggcgtggg gcgcctgcgg gccatggcgt
     6661 tgtggggccg gcagcacgtc gcacggcgcg gtatgaggtc gtgcgggatg gacttgccca
     6721 agtgctgtgt gctccggctg cggagcgacg agaatgccgt gaaggagctg ttgatccgtc
     6781 cggtcattcc cgctgcgatg agagcgaagc atcatgagga acaagcccga ttccgctgag
     6841 ttcgcgtccg ccggtacgcg tcacaccgta acccgtgccc aggtcgaagc cgcggcctca
     6901 cgtcttcccc cagcgcacag cgcgacgttc agccagaacc gtgtgtggta cgccctcgtc
     6961 ggcaccggtc tccactacgt cacggacctg atggccgagg ccaccggtac caaaccctcc
     7021 gacgtggaaa ccgctcgcct cgctctggat gcactgggct tccccattgt ctgctgggcc
     7081 tggggcgacc ttctcaccac cggtcatccc ggacaccgca tccgccgatg aagagccgcc
     7141 cgccccaggg ccgttgccgt ggcgcccggg gtgggtacct ccgcgatgtc gtggcctgac
     7201 tgggaaggtg gtggaagcgt ggcacggggc gctgacggct gcacgcccta tcgggggctg
     7261 atcttggact tcgtgggggt gctgaccgag ggagtgaggg acgcgcagca ctcctggtgc
     7321 gtatctgagg gcctcgcccc cgacgcatgg cgaatcaccc ttgccgacct tcccgagggg
     7381 cgggaactgt acgcggcact tgagtcaggg cggctgtcgc aagccgagtg gaatcgccgc
     7441 acggctccgc tgctgggggt gggcgatcac cacaatctga tgggccgagc gtggtcgggt
     7501 gtgcgcccag cggtgaacat gatcgccctg gcgcgggccg cccggcgagc cggttacacg
     7561 gtggctatgt tgtcgaactc cttcggcctg gacccgtacg acccatacga ggcgttgggc
     7621 gtgtggaagc tgttcgacgt gacggtgatc tctgagcagg agggcatcgc gaagccggat
     7681 ccggaaatct accaacgcac tctggaacgt atgggtttgc ccggggaggt gtgcgtgttt
     7741 gtcgatgaca acccggggaa tctgcctccg gcagctgcgc tcggaatcac cacggtccac
     7801 gcggacggcc aagccggcac ggtcgagcgg ctgtcgagcc tgctggggct tctcccggcc
     7861 gacggcagag ttccaggtgg tgccgcactg gagccggaag aattctgagg cggtggggga
     7921 gaccgcatcc ggccggtggc ctgtatcgac ctctgcatct accccgttgg ggtcctcgtg
     7981 ttcccttatg ttcccttggg agggctgagg ggtatcgcga ggggattcga gtgtcgatcg
     8041 gaccaatccg ggtcagtggg tgtgcggatg cctggccggt gctggaggtg tgctttgccg
     8101 ccggggggcg gcggggctgg tgggcgtgcc ggtgggggcg gggaaggagc acgccgtgat
     8161 ggggtgatcg agtcatcttg ggcgggggcg ggacctctga gcattctcga tgtcgttttc
     8221 gccgcgctgt ggtgtggtgg cccaggacgg gcgccagacc acgtcgggga gtcttggcag
     8281 ggtgccaagg tgggtgatga ttcggcggag ttccggatgc ggattcgttc tggggaggat
     8341 gagcgagagc gggtatgcga gggtcggatt cacgataggg atgcggcgta ggtcgtggtt
     8401 cgtcggccac atgtatcggt cgcgtgtccc gaccagggtg gccacgtccg cggagtctgc
     8461 gagggtgtcc aggagtactt cgtctccgaa gtgtgggcct gtcgcgtcga tgcgcaggtc
     8521 gaagtgcgtg gcgagctgat cgtagaactc tgcccattcg cttcggggtg cgatacccgg
     8581 cacccatatc cggtgtttgc gcagctgtgg cggcgtcagt cttcgcgcgg aggcgagcgg
     8641 atgtctcggg ccgacgagaa gttccagcgg ggaatcgaag gcgtggatca tttgcaagtc
     8701 gggtggtagt gcggccgggg caatgagggt acgaaacgag gcgtcgatat cgcctgcttc
     8761 gacggcggcg accaccacgc gtgggtcgtt ggctcggagg gtcaccacgt cgagatcggc
     8821 ttcgggacgc gaccgccaat agtcgtgcag gacgacggct tgcgcgcttc gcaggccgag
     8881 aacatcgatc cgaagggccc gggagcccgg cctgaccgcg ttgatggcgc gctcgacccc
     8941 cgcgacgatg ctccgggcat gggagagaaa cgcctgaccg tcgagtgtca gctcaactcc
     9001 tcgggcggtg cgtgtgaaca gacggacttc cagctcgcgc tccagggtgg cgatccgctt
     9061 ggagactgcc tgctgtgtca cgcccagctc gtcggccgca tgctggaact ggccgagctc
     9121 ggcggcccgg acgaacgatc gcaatgcctc ggtgtccact ggttcacctt aggcgtgctc
     9181 aactcatcgt tgtgactggc cgaggatcgg ttgtccgaac aagctccttc ttccggcgcg
     9241 tcggcgggat ctggccagtc tcaaaggccc gacgtacgtg gtccctggtc cctggtctcc
     9301 ggtgacttgc ccctctgccc tcgcacgctc gacgagtgcc atgagtgcca tgagtgccat
     9361 gagcgcgacg agcgccacga gtgccttgga ctctccgatc tccatgggca gggtttgggg
     9421 cacaccgtca cccgacgcct caagatagcc gcagccgcag ccgcagccgg tgggtgtgtc
     9481 ttcggtggga tgtgactggc gctggtcctg tgggtgaggg gtagggcggg tcctcggggt
     9541 gttgatagtg caacccgtgt gaagtcagtg gttgttgggg caaaagtggg agggggtatt
     9601 ccgggatatt catagcagga cggtcgattg tggatcttga atcgtggtga gccgcgtggt
     9661 tctctgtcga tcacacccag ggcggcgact ggggcgcaag ccccgtcggt cggcggcgag
     9721 ttgggagtca tcccggcatc cgcggaacct tccgcaccgg aacgcgttcc gccctgggcc
     9781 gtcgcaccag tcaacgggga ggtgaactgt gatgcagggc aacgaactcc aggagaccga
     9841 caagctccag acctacgagg cccccaagat gatcgagtgt ggctccttcc aggaggacac
     9901 cggctacttc gggctgaccg gctacgagaa ccttttccac ttctacgaca agctccacta
     9961 gggccgacgc tgatgcggca caccccgtaa ggacactgac atggccgatg ccggttggca
    10021 gtacttcgtc gcgctgccgg acgacgaggg cgcggcagcc gccatcggca ggttcccgac
    10081 ggacggtgtg cgcgtcctgt tgaggcaccg gtccggccgg ccctgtgtgg ccggccggct
    10141 ggccgaggac cgggtcctgg tggccgaacg gggcgacacc cggctcgccg tgatcggcca
    10201 ctgctcggcg acccgggacg aactcgccac ggcggccgac cggatcgacg aggtgaccga
    10261 cctggaccga ctgggcctgg cctgggccgg cagctaccat ctcgtcgcct ccgtgcgcgg
    10321 ccaactgcgc gtacagggca ccgcctccgg gctgcgccgg atcttccacg gtgagctcgg
    10381 cacactcacc atcgccgccg accgcgcgga cgtcctggcg accgtactgg acgccccgct
    10441 cgatccggcc ctgctcgccc tgcgcaccct ggacgtgctg ccgcacccgc tgggcgacct
    10501 gccgccgtgg cgcaacgtct ccgcggtccc tccgggctgg tacctggcac tgccgcagga
    10561 cggccggcgg ccacgggtcg aacgctggtg gcaggccccc gaaccggtgc gttcgctggc
    10621 cgcgggcggc cagttgttgc gccaggcact ggaggacgcg gtgcggctgc gcgcccgcgg
    10681 aacccggccg atcagcgcgg acctctccgg cggcatggac tccaccagca tcgccctgtt
    10741 ggccgtccgg caccggccct cgctcaccgc gctcaccatg gagaacgagg atcgggccga
    10801 cgaggacgcc cagtgggcca ggcaggccgc cgccggcctc ccggacctcc accacatcgt
    10861 ctattccagc cgcgaactgc cacgcttctt cggcggcctc acggcggtgg agggcgttcc
    10921 cgacgagccg tccaccgcgg tactgagcgc gccccgactg cgcgccgtgc gacagcgggc
    10981 cctcgcgcac ggctcgcggc tgcacctcga cggactcggc ggggaccaac tgctgtgcgg
    11041 tcacccggcc tatcaccacg acctgttgcg ccaccggccg ctgttggccg cccagcgcct
    11101 cagggtgctg acccaactac gccggagcaa ctggggcact gaggcccgag gtctgctgga
    11161 cggccactcc taccgccgct ggttcacgga ccgggcccac ggccgcgccc gccgcacccc
    11221 gagcccgctg tccgcctggg gccacttccc gggcctgccc gcatggctca ccccggacgc
    11281 cagggacctg gtgacccgca ccctgcgcga cacggccgcg accgtcgagc cgctggcgtc
    11341 gacgcgaggg cgacacaacg acctcctggc gatccaggac gccggacgga tggtccgcca
    11401 gtgccaccaa ctgaccgaga ccggggactt cagccatacc tcccccttcc tcgacgaccg
    11461 cgtcatccag gcatgcctgg ccgttcgacc cgaacaacgc gtcacgccct gggagttcaa
    11521 acccctcatc aaggcggcga tggcagacgt catgccgccg gaggtgctga cccggcggac
    11581 caagggcgac ggcaccacca tcgtcgccga gggcttcgag gcgcaccgcc gggaactcgc
    11641 ggaactctgg gacgattccc gcctggccgc cctgggcctg atcgaccccg gaccgctgcg
    11701 cgagctgttc gagctgccct acaccaacag cctccaccaa ggtgcgatgc agtccgcgct
    11761 cagctgcgaa ctatgggccc gggcaacggc cttccaatcg gcagccgcca cccgcccctg
    11821 agcccgccac aggacccgag caggagacaa ccatgacatg gagactgcac cccgacgtct
    11881 cgaccgtgga caccgactac ggaaccgttc tgctgaacgg cggcgacggc cgctactggc
    11941 agctcaacgc gaccgcctcc ctcgccttcc gcgccctggt cgacggcagc acggtgcagg
    12001 agaccaccga gcggctgatg gcctccttcg acgtcgacga gccacgtgcc cgcgcggacg
    12061 tggagcagct gatggccagt ctccagcagg cgaaggtggt gcagcaggcg tgagttcggt
    12121 cgtaccgcac cgcacggagg tccggctctc cccgggccgc cgcctcctgg tgctgctcgc
    12181 cgtggccgtc gcccggcgcc tggccgccaa gccgccggcc cggacccgcg ccatactgac
    12241 ccgcctgcgc aggggcgccc gcgcggccac gtacgcggag gcccgcgccg cccgggacgc
    12301 cgtggtggcc gtcagcctcc gctgcgccgg ggacgagggg tgcctgcctc gttcgctggc
    12361 gaccgtcctg ctctgccggg cacgcggcac ctggcccacc tggacggtgg gagtacgcgc
    12421 ccgtctaccg ttcggcgccc atgcgtgggt ggaggccgag ggacgcatgg tcgaggagaa
    12481 ggcggaccct tcctacttcc gccccctgtt ctcggtcccg gcggaagggg cctgacgcgg
    12541 gtctctcgct cgtatcgggg cggctggacg ccgggtctcg ttccgccgag acgacggcct
    12601 tccacgtgtg cgtgcaggca cggtcgtgga cgtcgggtgc ggcaccggct actacctggc
    12661 cggcgtactc gatcagcttc ccgacccccg cggcctgggg ctggacgcgt ccgtccgcgc
    12721 gttgcgttcg gcggcccgcg cccatcggcg ggccgcggcg gcgagctggg acgtcttccg
    12781 ccccttcccg ttggtcgacc aggcggccga tgtggtgctg gacgtgttcg ccccgcgcaa
    12841 tccgtccgag ttccaccggg tgctccgccc gtccggccgg ttgatcgtcg tgcgccccac
    12901 cgagcggcgc cctcgttcca ggcatccccg caccgccggt ggccggcgac tgcgacggcc
    12961 accgggacct cgtcggcagg atcgatggct tcggacggtc tcgatcggga acgcgcggac
    13021 tatgagagcg cgcggagtat gagagcgcga acagtgaagg cccggtggaa tccaccgggc
    13081 cttcacattc gagtagcggg gacaggattt gaacctgcga cctctgggtt atgagcccag
    13141 cgagctaccg agctgctcca ccccgcgtcg gcaagaggaa ctctacggca ctttcccgga
    13201 tcggccgaat cgacctccgc cccggcccga cggcgggctc ttcgggccac gcctctactc
    13261 tggggcgcca ggggcgaacg acgaaaagcg atgagcggcg aaggaacgga gcgtgcggtg
    13321 acggacgggg gagcgagcgg cgatgagctg atgggcaagg tcctcggggg ccgttaccgg
    13381 gtgaccgcga cgatcgggcg gggcggcatg ggcgtggtcg cccgggccgt ggaccaactg
    13441 ctgaaccgcg aggtcgccgt caaggtactg cgggccttca ccgacgcctc cgcgcccgaa
    13501 ctggtcgatc tgcggacccg gatgcagcgg gaggcgcagg ccgccgcccg tattcggcac
    13561 agcggcgtgg tcaccgtgca cgacgtgacc gaggagcagg gcctgcccgt catcgtcatg
    13621 gaactcgtcg acggaccttc gctcgacgac gtgctgacgg agcgcggcac gctggagccg
    13681 cacgaggcgg cggcgatcgg cgccaagctg atggacgcgc tcgacgccgc gcaccgggtg
    13741 ggcgtactgc accgggacgt caagccggcg aacgtgctgc tggagcacgg cgggcgggtc
    13801 gtgctcaccg acttcggcat cgccaccatg gatgcctccg gcgacgaggc catggccaag
    13861 ctgacccaga gcggtcagct ggtcggctcc ctggactacc tgccgccgga gcgcgcgcag
    13921 ggcacggtgc ccagtcccgc gtcggacatc tggtcgctcg gtatgacgct gtacgcggcg
    13981 gtggaaggca cgtcaccgtt ccgccggacg tccgtgtggt caaccttgtc ggcgatcgtc
    14041 accgagccgc tgccggagcc ccgacgcgcg gggccgctga cgccggtgct gcaggcactg
    14101 atggcgaagg acccgaagaa ccggcccacg gccgagcagg cgcgtgaaat gctgcagtgg
    14161 gcggccgcgg gcaggacgat gaacctcgcg ccgccggccc ctgtggcccc cgctgctccg
    14221 ccggtacagg ccgccggccc gacgcctccc caggcagcag ccaccccggt gccgcccgga
    14281 tccggtgccg tgccgccgtt ccacccgtcg tccccgcagc ctccgtacac cggataccca
    14341 ccgtccggcc cgccgcccgt cacacagccc tgtatgccga ccgcgggcca cgctcacggt
    14401 gccggccccg ccaccggccg cggccggcgc tcgcgtcgta ccctcatcgc ggccgcggcc
    14461 gccttcgtcg tgctcgcggg cggcggtgtc acgtacgcct tgaccgcgca gcacggtgcg
    14521 gtggacggcg accggccgca ggcggcgccc ggagccggct ccccggtggg caacggtcgg
    14581 ccgagcggcg gcggaacagc cgacggcatc aactccccgg gctcctcgcc gtccacggaa
    14641 tccggaaagc cgtccggtgc gacctctccc tcctccgccc cgccgtcggc cgagcccagt
    14701 gccgcgccga gcacgtccgc ttccccttcg gccaagcccg gttcggggcc gacgacttgc
    14761 agcggctgga gccaccacga cccgaagccg ggaatgtacg gctacctgtc cggcgatcac
    14821 cacatcctga cggggcccta ccaggtctgc tcctccgtgg ccgcgaccaa gtcgggcacg
    14881 aaggtgtggt tccactgctc cgtcgagaac gcctacggcc acaagtggct ctacgtccgc
    14941 atcggcggga cgaagaacgc gggctggatg tccgcggaca ccgtcatccg gcagagcggt
    15001 tggccagtcc ggtgttagcg gcgccgccgc cgttccggga cgggtgcgga acgtcccggt
    15061 ggacgcagct cacagcgcta cggcatgccg ttcacagggg ttggaagcgg cagctgcccg
    15121 gacgttcgac gtagacctgt cccgtctcga cggcgtagag ccagccgtgc aggcgcagct
    15181 tccccgccgc gatcctcatg gcggcgaacg ggtacgagcg tatgttgccc agctgtatca
    15241 gcgtgtggag ctgggcaacg gtgtcggggt ccggccggtc gggacgtgtc acgcgtgccg
    15301 tgcgtgcgga cggcggttcg cccgttgcac gtgtcccgtg gccggacagg ctgagccact
    15361 tctccagcag tggcaggaac gtcagttggc gcgggttcat caggccctgc accgccgcgc
    15421 agtgtgagtg gctgcagacg acgatgtcgg gtacgtgcag ggcggtgacc gcgtactcga
    15481 gtgtcgcggc gacgccgcag tctgcctgcg gccggtagcg agggacgacg ttgcccgcta
    15541 cccgtaattc gaacagttcg ccgggtcggg ctccggtgaa catggtgggg accacccggg
    15601 agtccgagca cgtgatgaac agcgccatcg gccgctggcc atgagccaac ttgcccaagc
    15661 tgccgccctg ttgggtgacg cgtcggggaa aactgcgggc gtggtccagg aacctttgca
    15721 catcgacctc gcttcggcct acggtgcgca ctcgaccgtc ggcggacgcg gctcgatcag
    15781 cttcagcacc tgttgtacgg cggcgtcggg gccgtccgcg cggtgcacgg cggcgaccgc
    15841 ggtctccagg tagggcgaat cgccgtgcag aggacggtag accacgcccg ggatgcccag
    15901 cgtgcgtacc tgctcggggg cgagcgccag gcacaggccg gcggcgacgt agctgagcag
    15961 ccccggcagg tcgtccgcct ggccgcgtga tcggggtgtg aagccggcct gcgcgcaggc
    16021 gagcgcaacc tgctcggcca gtccgggcag ggcgccgggt ttgggcgtcg cgaactgttc
    16081 ctcggcgagt tcccgcaggt cgaggcgtga cttggcggcg agtggatggt gttcgggaag
    16141 ggccgccacc agtcgttcca cgccgatccg ccggacggtc agtcggtccg tgccggtgac
    16201 ggggagccgg accagtgcga ggtcgagcgt cccggcctgg agcatgtcga ccagttccgc
    16261 ggaggggtgt tgacccaggt gcagccgcag agcgggcaac tgcgcgtggg tgcggcgcag
    16321 caggcgcggc aggaagtcgt agccgaggct gctgatgaaa ccgagccgga gctcgccctc
    16381 gtgtccgctg gcgatccgcc gggcccggtc cacggcggcg gcctgcgctt cgagcagccg
    16441 ccgggcgtcc tcggcgaacg cgcggccggc cggggtgagt cgggcacccc gcggaaggcg
    16501 gtcgaacagg gtgacgccga ggccgcgctc cagtcgctgg atcgcctggc tgagcggtgg
    16561 ctgccgcatg gcgagccgct cggcggcgcg gccgaagtgc tgttcctcgg ccaacacgac
    16621 gacctgttgg aggatgcgct gggtcaattc catattgcac agcatatgta agcggcaggg
    16681 aagaagtatt ggacggtatg gggcgccgag gatttgactg gctgtcaacg gtccggtgcg
    16741 cgaagccggc cccggcggag atcggagaca tgccatgtcg acaggacggg aagcggacgg
    16801 tggcgtcggt ccgctgaacg gcgtgcgggt ggtcgagctg gccagcgtga tcatgggccc
    16861 gtacgcggcc caacagctcg gcgacctggg ggcggacgtg atcaaggtcg aaccgccgac
    16921 cggtgacctg acccgtcact acccgccgac ccgcagcccc gggatggggg tgatgaccct
    16981 caacctcaac cgcaacaagc gcagcgtcgc cctcgacctc aaggccccgg gcggccgcga
    17041 cgccctgctc gccctcctcg cgagcgcgga cgtcttcctc accaacgtcc gcccgcaggc
    17101 cctgcggcgc ctcgacctgg cctacgagga cgtggcggcc gtcaaccccg gcctggtcta
    17161 cctcaacgcc cagggcttcc gcagcgattc ccccctcggc gggcacgcgg cctacgacga
    17221 cgtcgtgcag gcggcctccg gcctggtgtg gctgaacgaa caggtcagcg gcgtaccgca
    17281 ctacgtcccc accgtgctgg ccgacaagat ctgcggcctg gtgatcgtgc agtcggtgct
    17341 cgccgcgctc caccaccgtg accgcaccgg ccaaggccaa cacgtcgagg tcccgatggc
    17401 cgacaccatg ctggccttca acctcgtcga gcacctggcg gcggcgaccc tcaacccgcc
    17461 cgcggggccg atcggctacc cgcgggcgct cagcccccgc cgcacggcct cccgcacggc
    17521 ggacggctgg atgtgcatcc tgccctacag cgaccgcaac tggcgtgact tcttcgcctt
    17581 cgtgggccgc ccggaactgg ccgacgaccc gcgcttcgct tcgtacgccg cacgcgtcca
    17641 caacgccgac gaactctacg tactggtcgg cgagttcacg acccggcaca ccaacgcgca
    17701 atggcaggag ttctgcgacg cgaccagcat ccccgccgcc ccggtgctga gcctgacgga
    17761 ggccgccacc agcgcctacg ccaccgaagg cggtctgctc caggaagccg agcaccccac
    17821 cgagggcgga taccgcctca tcggccagcc cgtgcgcttc tgggccacac cggccggcct
    17881 gcaccggcac tgcccgcggg tcggcgagca caccgaggag gtcctcgccg agatcggcca
    17941 ccggccgcct gcctgagccg tcacccgtca ccaacccccg tacccgcgga ccgaatcgag
    18001 gacccgtgaa cgagcaagca cgcctggacg agcaagcacc cctggacgag caagcacccc
    18061 tggacgaaca ggcagcgccg aacgagtggg aaccgctgcg cgtcgagcac cggccgaacg
    18121 gcgtcgccgt gctcaccttc gacaaccccg acaagcgcaa cccgatgacc ggacggctga
    18181 ccgcacagtg gcggcgcgcc atgcgctccc tgcggcagga ccccgacctg cgcgccgtcg
    18241 tgatcaccgg caccggcccc gccttctgct cgggcgccga cctgggggaa ctcgccgacc
    18301 gacacggcca gtccctcccc ggcacccggg cccagctgtc ggacttctac cggacctggc
    18361 tgaccgtccg tgacctgtcc gtccccaccg tggcggccgt caacggccac gcggtgggcg
    18421 ccggactggc gctggccctg gcctgcgatc tgcggtacgc cgcggtggag gcgaaactcg
    18481 gcgcgccgtt cgtccgactc ggcctgcacc cggggatggc caccaccgct ctgctcgccg
    18541 aggccgtcgg cccgtcgagg gcgcgagaac tgctgctgac cgggcggctg atcagcggag
    18601 cgcgagccgc caccatcggc atggtgcacg aggcgctgcc gtccgaccag gtgctgcggg
    18661 ccgcgctcga cgtggccgac gagatcgccg ccgcggcccc gctggcggtc cggctgacca
    18721 agagcggcct ggcccagggg cagcccaccg tcgagcgggc gctgacctgg gagggactgg
    18781 cccagccggt gacgaccacc accgacgact tccgcgaggg cgtccaggcc cgccgggagc
    18841 gccgccgccc gcacttcacg ggcgcctgac caccaccgcc gaccgcgcac ccgtcactcc
    18901 gcgcacccgt cactccgtac accaccactg cgcgtacccg tcactccggg tacccgccac
    18961 tgcggatacc caccattccg tccgaggagc accgatgact ctctccgtcc tcgatccagg
    19021 ggccgtccaa cttccgccag aagcagcccg gttacgacag gaggtgcgcg acttcctcgc
    19081 cgcggaacgg gccgccggta ccgtcctcgg tcggcccgac tcctggctga ccggctggga
    19141 ccccgccttc acccgccgcc tggcccggcg cggctggatc ggcatgaccc tgccgccgga
    19201 gtacggcgga ggcgggcgca gcaatctcga acgccacgtc gtcatcgagg agttgctggc
    19261 cgccggcgcc ccggtctcgg cccactgggt cgccgaccgg caggccgggc ccagcatcct
    19321 gcgccacggc accgaggcgc agcggagcca cttcctgccc cggatcgccg ccggcgcgtg
    19381 cttcttctcg atcgggatga gcgagcagga cagcggatcg gacctggcct cggtacggac
    19441 ccgggcggag cggaccgccc acggctggcg gttgaccggc accaagatgt ggacgggcgg
    19501 cgcgcacgtc aacgaccatg cgatcgtgct ggcccggacc gacgactccg aggaccggca
    19561 cgccgggctg agccagttca tcgtcgacct gcgcgatccg cacgtccggg tcgagccgat
    19621 ccgtctcctc agcggcgagc acaccttcaa ctactgccac ctggaaggcg tcgaactcac
    19681 ggacgacgca ctgctcgggc gccccggtga cggctggcgg caggtcaccg gcgaactggc
    19741 cctggaacgc agcggacccg agcgcttcct gtccaccctg ccgctcctct ccgctctggt
    19801 gaggcagttg cagcggaccg gcgggtgcgg tcccgagcag caggcccgcg tgggccggct
    19861 caccgcgcgc ctgtcgtcca tccggcagct gtcgttgggg gtggccgcgg cgctggcggc
    19921 cggccgcccc gccgacgtgc aggcggcact ggtcaaggac ctcgggaccc gcttcgaggg
    19981 cgaactcgtc aacgaggtcc gcgagatcct tccgatcgcc gcccgtttcg acgccacccg
    20041 cggcagctac cccgaactgc tggccaccgc gatcctgcat gcgccgggat acacgctgcg
    20101 cggcggcacc aacgaaatcc tgcgcggcat catcacccga ggtctggagc tgtcccgatg
    20161 agcatcgaat cgcgcgccga atccgccgcc gaaccccgct ccgaacgcgc cgccgaggcc
    20221 ctgccgccgc tcgatacggc cccgaccgcc ctggtggccc tggcgcggga agccggctac
    20281 cgcggcaccc cggcaccgct cgccgagacg ctgctcgtcg cacgcccgtt gctggccgcg
    20341 gccgggctcg ccgtcccgga cggtcaactc accatggcag ccggcccgct cgacgtgcgg
    20401 ttcacccacg tggacaccga cagcagggtc gggccgtcag gggcggcagg caccgatgac
    20461 gccctacggg tcagcggcac gctgcaccgg gtaccgtggg cccgggccgt ccaagccgcg
    20521 gtggtgctga ccgaggggcc gggcggcggg cccgtgctct tcctcctcga agccaccgag
    20581 tggcggcagc tggcgggcac caacctggcg ggcgagccca gggacgacct ggtgctgctc
    20641 gacgtggccg tccccgccga gcgggtccgt cgcgttccgg ccgcgctggt ccgggaggcc
    20701 gcatggcgct ccggcctggc gcgggccgcc ctgatcgccg gtgcggcacg ccgctgtgtc
    20761 gagctgacgg tcgatcacac ctccgcccgt gtgcagttcg gccgaccgct gagccacttc
    20821 caggccgtca agcaggagga ggccaagctc gtcgaggagg cggccctggt cgccgcggcc
    20881 gtcgaggcgg ccgcgtccgc cctttccgaa ccggactccg cggagttcac cgcgtggctc
    20941 gccgccgcac aggccgccgc ctcggtggcc gagatcaccc gcatcgccca ccaactgcac
    21001 ggcgcgatcg gcttcaccga actcagcccg ctccgtctgg ccaccacccg catgtggtcc
    21061 tggcgcgacg aggacggcgg tgaacgggcc tggcagcaac ggatcggtcg gcacgtactc
    21121 gacggcggca gcggcgggtt gtggcagcag gtgaccggcg gctgacccgc ggccgccccg
    21181 cgatgcggtc gagcccccgg gcgccgaccc gccggtcaca cggaacgcga caccgtcgag
    21241 accggcgcgg ccagccggtg ccgtgtcagg ccaacacctc acgaagccag gacctttccg
    21301 cgcggctggt ggcgcgggcg atggtgagca tgccgcgccg gtaggggtcg tcggtgtcgt
    21361 cggcgcgcag ggggcggtcg ccgtcgtgga agaagctcgc gggctgttcc aggaattcca
    21421 gtcggcggcg cagtaccgcg tgctggtcgg tggtgtcggg tagccgggag aggaaggcca
    21481 ggaccgtgaa gtaccgggtg ctgtcggtga tgtcgaggcc gtcggcatcc cgcagtcggc
    21541 gcaacagctc gcggcggccg gtgtcggtca ggctcagggt gtggcgctgg gcggccgagg
    21601 tgcccggttc ggtccgtcgg tcgagcagcc cggcacggac cagtcgattg atcgccgggt
    21661 agaggctgcc gtcgctgacc ggccgggcat ggccggacaa gtgcgctatg cggtgccgga
    21721 gttgatagcc gtgcagcggc ccctcggcca ggaatcccag gatcgcgagt tcgagcatgc
    21781 tgctactctc gcacatcgaa acgaggtacc tcgaatcgat gcagggggca gggatgacgt
    21841 acaccgagga atgggtgacc gcacgggcgc gccacgccta cgagcacggc caggcatcgt
    21901 tcgacctacg acccgaacgg acggcgctgc tggtcatcga catgcaggac gaattcgtcc
    21961 ggcccggctg gagcccctac tgggtgcccg cggcgacccg gatggcgccc cggctgcggc
    22021 gactggtcga ggactgccgg gacgcctcgg tcccggtgat ctggaccatc ttcgacgaca
    22081 cccatctcgg actggaccgg ccacacgccc tgcgcttcct cccgcacgcc gacaccgact
    22141 ggcgccgacc cggccccgcc gaggtctggg gccggatggg tcgccgcccc gatgaggtcg
    22201 tgatccgcaa accgtcctac ggagcgttct acgacacccc gctcgacacc gtgctgcgca
    22261 acctcggccg cgacacggtc gtcgtcacgg gaacgctcac caactactgc tgcggcacca
    22321 cggcccggca ggcgtacgaa cgcggctacc gggtcgtctt cggatccgat gtcacggcca
    22381 ccgacgacga gtcccggcag gaacccgaac tcgccgtcct gcgcaagggc ttcgcgctcg
    22441 tcctgaccgc cgaagagatc accgaccgac tgaccgcggc cggccggctc cggccgtgac
    22501 aagccgggcc gacggcccgt gcgccacccg cgcgc
//
