LOCUS       NZ_JAPTYM010000001     21215 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7534192
            Orig. end                         :: 7555407
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21215
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="30"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21215
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21215
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11215](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11215)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(752..766)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     misc_feature    753..767
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     gene            complement(1101..2744)
                     /locus_tag="O1M07_RS33045"
                     /old_locus_tag="O1M07_33040"
     CDS             complement(1101..2744)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358077.1"
                     /locus_tag="O1M07_RS33045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33040"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_189862011.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3.3e-49, bitscore:
                     165.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-28, bitscore:
                     98.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAKALKAEGVEVIYTLCGGHIIDIYDGCVDEGIDVVDVRHEQVA
                     AHAADGYARITGRPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGARTQHKMGSL
                     QDLPHVEMMTPITKFAATVPDTARAADMVSMAFRECFHGAPGPSFLEIPRDVLDGKVPV
                     AAARVPGAGHYRASTRSAGDPEDVQRLADLLIRAEKPAILLGSQVWTTRGNEAAVELVR
                     ALNVPAYMNGAGRGTLPPGDPHHFQLSRRYAFANADVIVIVGTPFDFRMGYGKRLSPDA
                     TVVQIDLDYRTVGKNRDVDLGIVGDAGLVLKAVTEAASGRINGGAGKRKEWLDELRAAE
                     QAAVEKRLPQLRSDACPIHPYRLVSEINEFLTEDSIYIGDGGDVVTFSGQVVQPKAPGH
                     WMDPGPLGTLGVGIPFVLAAKQARPEKEVVALFGDGAFSLTGWDFETLVRYDLPFVGVV
                     GNNSSMNQIRYGQRAKYGAERERVGNTLGDVPYDKFAQLLGGYGEEVRDPADIGPALRR
                     ARESGKPSLINVWIDPDAYAPGTMNQTMYK"
     misc_feature    complement(3033..3051)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.71"
                     /tool="antismash"
     misc_feature    complement(3055..3073)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.59"
                     /tool="antismash"
     misc_feature    3058..3076
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.68"
                     /tool="antismash"
     tRNA            3487..3571
                     /anticodon=(pos:7537712..7537714,aa:Leu,seq:gag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="O1M07_RS33050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="O1M07_33045"
                     /product="tRNA-Leu"
     gene            3487..3571
                     /locus_tag="O1M07_RS33050"
                     /old_locus_tag="O1M07_33045"
     gene            complement(3553..5043)
                     /locus_tag="O1M07_RS33055"
                     /old_locus_tag="O1M07_33050"
     CDS             complement(3553..5043)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019149.5"
                     /locus_tag="O1M07_RS33055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33050"
                     /product="recombinase family protein"
                     /protein_id="WP_229921814.1"
                     /transl_table=11
                     /translation="MVIGEPQRAFYGAQFGNTFPLFAHYGVPLWVPEVGGPIDADNEAH
                     DLIMSVFGGMSKGERNRIKVRVHAAMAAQALTEGRYLGGRPPYGYRLCDLGPHPNPAKA
                     ADGKRLHGLEPDPATAPIVVRIFTEFLRGLGIFAIAEGLTRDGISSPSAHDQARNPHRD
                     TRAWAKSAVRAILTNPRYTGRQIWNRQSTYETLLDIEDVSLGYTTAMRWNAQDKWIISK
                     KTVHTPLIDDDTFAAAQQMLHRRAHTGSAHPVHRTRNPYLFRGRITCHTCTRRMQGQWS
                     HGDAYYRCRFPEEYALANRIHHPRNVYLREKWITPALDDWLTRVFQPHRLDDTIDLMAT
                     AAATESHTATQTTAAEAARAVIADCDTKLATHRAALEAGADPTVITKWIAETQAKRARA
                     EADLRTATATHGTGARMTRDEIARLVRSISDLAAVIRQADPDDKAEIYRRLGLQLTYTP
                     GQQTIRAKIAPDLHASANDKSLRFQRNRRDLVSVRGGT"
     misc_feature    5708..5722
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    6037..6056
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 22.94"
                     /tool="antismash"
     gene            complement(6044..6979)
                     /locus_tag="O1M07_RS33060"
                     /old_locus_tag="O1M07_33055"
     CDS             complement(6044..6979)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089117.1"
                     /locus_tag="O1M07_RS33060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33055"
                     /product="TRM11 family methyltransferase"
                     /protein_id="WP_189862012.1"
                     /transl_table=11
                     /translation="MSSPDSVWNTAPTSAPARRKGRYVPGSAAHPAKMHPGIAAHAITT
                     YTRPGDLVLDPMCGIGTTLVEALHLGRNALGIEYEPQWATLASLNARAASQESGTGTGI
                     VRCGDARHLTALAPTDARGEVDLVVTSPPYGPSVHGQVRSSRETGEPGVVKKDFRYSHD
                     RANLAHVPTAHLLEAFTEILAQCRTMLRPGGTVVVSTRPWREHGELIDLPSAVLAAGKT
                     AGLTPSERCVALLAGIRNSHLVTRPSFFQMKNVRDARRGGIPLSVVQHEDVLVFNKLRR
                     AAPAQPREHRPSNTTAFRSRTCSRSGRYGR"
     gene            complement(6993..7601)
                     /locus_tag="O1M07_RS33065"
                     /old_locus_tag="O1M07_33060"
     CDS             complement(6993..7601)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018851586.1"
                     /locus_tag="O1M07_RS33065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33060"
                     /product="hypothetical protein"
                     /protein_id="WP_229921815.1"
                     /transl_table=11
                     /translation="MPTTIWLPAPDEPHAAPAAGTVLPDWAIERIRTVFTTRAGQLPAP
                     LLKISIRDTEPGMDARTPVITYTDGTPSKLSLLLAELHPDTLPDPTNTPAYGGMSEMPG
                     AMEDGWPGFFHRAHRLLPADGLLLLATRQRRDEGILTDPLGSLIACARTAGFRYLQHVI
                     VAHAHPADDHLIPNPPADASPGVAHSDLIALSAIHPTGA"
     misc_feature    complement(7960..7973)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            complement(8095..8247)
                     /locus_tag="O1M07_RS33070"
                     /old_locus_tag="O1M07_33065"
     CDS             complement(8095..8247)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS33070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_33065"
                     /product="hypothetical protein"
                     /protein_id="WP_372516394.1"
                     /transl_table=11
                     /translation="MIHAAQPNHGTVPRFMAQAPLIPTVQLDLDRPDGAYFPVERAVRL
                     GRGLA"
     gene            complement(8437..9918)
                     /locus_tag="O1M07_RS33075"
                     /old_locus_tag="O1M07_33070"
     CDS             complement(8437..9918)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_045934309.1"
                     /locus_tag="O1M07_RS33075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33070"
                     /product="IS1182 family transposase"
                     /protein_id="WP_189862083.1"
                     /transl_table=11
                     /translation="MFEIEPIEVKRSPGRAAAVDKTFRTFDPHQVLLLPPSLDDWLPEG
                     HLARFVADLVDEVLNLSPILADYTEKRGYPPYDPRLMVRLLIYGYTTSVRSSRAIERKC
                     SDDVAFRFLAADQAPDFRSIARFRRRHLDALGDLFTHSLHLATKLGMVKMGRVALDGTK
                     LEANASKHKAMSYGRLVDKEEQVEAEIAALEAKAAALLADAEATDEAEDATFGVDGKDM
                     DLPAELDRREKRLARLQAARAQIEAEAADKARRHAEDKERRRRQRTGTSDQQAVTDAGE
                     AAAAKARPKPKAQANFTDPDSRIMKNSDGAYIQAYNAQAVVDEAHQVITAADVMTNASD
                     ALNYTTMLDQSAQNTGRHPKQALVDAGYCSETNLEAARERQLACGADTFMATGRLGHDE
                     QVQPAPRGRIPKDATLKERMARKLRTKPGRKAYSRRKAIVEPVFGQIMTCQNGRQLLLR
                     GEDGARGEWRLLAACHNLRKIFRHAGTAGIGALAG"
     misc_feature    complement(9882..9894)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            complement(10001..11215)
                     /locus_tag="O1M07_RS33080"
                     /old_locus_tag="O1M07_33075"
     CDS             complement(10001..11215)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="O1M07_RS33080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33075"
                     /product="hypothetical protein"
                     /protein_id="WP_189862014.1"
                     /sec_met_domain="T1TS (E-value: 3.8e-57, bitscore: 193.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFEQGLPAGNGCMQGSALSEGLLRPRGIGTAALRLAADLRAGTG
                     HAEPSPPVATAGQSRGIPPLFCPIPSSIHPHAADIERRALAWAEEFGLGTSEVGRRRLI
                     GSKSAQWCCRLAPDGDPELLELAAEWTYASFLFDDDHLDESGSQPDASVSMIGEVLRAL
                     DSPESTDASNSPYPAAYRDLSRRLRKAAGAVAVRRWIDGHTEWFLGALSGLTYRAASRH
                     FSLGDCLNMGHRDAGIKICYSLVEIANGAALPDDVLLASRPLQVATQAAHFLVSADAAI
                     FSFDREVDQGSEQINLVNALMRHLDCDRGRALVEAVALRDAVMVLLMQLRRQTPGVVEQ
                     LYLRQLGTFVSGNLHWCLTNERYNTEVGRSPGSTGLSSMPTEGTIDPRTLPQIGWWWRG
                     TPTRG"
     misc_feature    complement(11556..11572)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.25"
                     /tool="antismash"
     gene            11640..14192
                     /locus_tag="O1M07_RS33085"
                     /old_locus_tag="O1M07_33080"
     CDS             11640..14192
                     /GO_function="GO:0004521 - RNA endonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037707.5"
                     /locus_tag="O1M07_RS33085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33080"
                     /product="CRISPR-associated endonuclease Cas3''"
                     /protein_id="WP_189862015.1"
                     /transl_table=11
                     /translation="MFDIHQGDREPDVRAAWAKLGTKRDAEPHPLICHALDTAAAAQVI
                     AQILCRGCVGARLRRMLEPLDGSELWISALCGLHDLGKYSPTFQSLRLDVAELYLPETA
                     QRDMRSLVKNNLDGARQDVHHGWYTTVHMQELLLTWGAKPDVARDIAITLGGHHGVFPP
                     ASTRSNAKNSLGESGAARWASWRTGLVEAFLRAWGVKAHEAAWGEVERDLGAMVVLAGL
                     TTAADWVASDRRGLADVPTDFDLESYAEEARLTEAGKIDGIGWEAWVPPQDVSFRGLFP
                     DKRDVRPVQEAVEKTVASLSGPGIVVIAAPAGEGKTEAGLQAATALVRKLGLAGFYVAM
                     PTRATSNQTYRRAAELLERVGAASPLQLLHSSAAEVVAAERNRRDRTGTLQPSGIGPDT
                     ELSTDTVVRHQDTSRQDKEARGWFAHKKRGLLSPTGVGTVDQLLLGALLGRHNFLRLTG
                     VSGKVVLFDEVHTYDQYQLALLESLLRWLGYLQVPVVLQSATLSAQLSNKLVGCWVKGS
                     LTAMAPASDSPAPVSLPTALPYPRVMWAEACAPEPQVKHVAASALAVNRVYALHMPEDL
                     CRDTWGQHVADALELAARDQCVGVFHNLAAQVDRDVEVAGKEIGKRADWTGIKIYGLHA
                     GMADRERALADTMVREAFGPPDDPATSRPARAVVFGSPLLAEGADIDFDAALVALAPID
                     RMLQAMGRVRRHVRDRPVGAGPIPISVFGVWEETKTARNGQKTVTVHFPRFTTTVTSHA
                     LLLRTWAVLRDRSHIRLDDLQQLIDAVYGDEDSIACPEGWETQWRTAHAAMRKSIDNKR
                     VKASVGVIPLPRTELSLEELTRPATTWRGTRLSHDSGS"
     gene            14351..16081
                     /gene="casA"
                     /gene_synonym="cse1"
                     /locus_tag="O1M07_RS33090"
                     /old_locus_tag="O1M07_33085"
     CDS             14351..16081
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="casA"
                     /gene_synonym="cse1"
                     /inference="COORDINATES: protein motif:HMM:TIGR02547.1"
                     /locus_tag="O1M07_RS33090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33085"
                     /product="type I-E CRISPR-associated protein Cse1/CasA"
                     /protein_id="WP_189862016.1"
                     /transl_table=11
                     /translation="MSFNLLHEPWLPVVRLDGSSAKLGIVEVLKQSKMLRGLVGETATV
                     SSALHRLLLAFLHRTFRPVDDAQWRSLWLDSSGTGFPEEELNAYAQDWASRFDLFDPEA
                     PFFQCPAVPAPRKWRSPAVLVGFRARGNNATLFDHSTDSDKLRLTPDEAARWLVTTQAY
                     DTSGKKTGYDGTGNPSGESPPTARFGCVLVEADTLYRTLMLNLLDYDPADRRPRPTQPD
                     DCPVWERPASESENENGQRLPRGWTDVLTWPSRRIRLSHTTVNGQHMVDGVIVSPGSSC
                     NLPIRDYEHMAAFRAPWFAETASGSSRAAVPMPVRLDIMRGVWRHSQELLLPPERRWWK
                     TYRSTGLKLSETGFPEEEPQRLRPAALEHLAHLADDGALPKDAVYTLRVFGQQVGSGGS
                     GSIAAWCEEVVPAPVALLRARNPRIGLLIGSAVALADDLGSILRALERGFRQEFDEQFT
                     LKEEDKREKAGFRYQSELRYWPRLPTSFAELLRNLALLENIEPGNYLAEAEHEALDKWR
                     RQAVRAADMAAEQWLRQQTRAGRTLLDASAHHERYRANCKNATRVLARAVAARTPPEEA
                     "
     gene            16078..16749
                     /gene="casB"
                     /gene_synonym="cse2"
                     /locus_tag="O1M07_RS33095"
                     /old_locus_tag="O1M07_33090"
     CDS             16078..16749
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="casB"
                     /gene_synonym="cse2"
                     /inference="COORDINATES: protein motif:HMM:TIGR02548.2"
                     /locus_tag="O1M07_RS33095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33090"
                     /product="type I-E CRISPR-associated protein Cse2/CasB"
                     /protein_id="WP_189862017.1"
                     /transl_table=11
                     /translation="MTEQSTSTTPASRVPRERQEAFVRSLYALAPGQRLGSDGQDATQG
                     TARDVLAHLRRSATQDQPNLTVCSLVFEHDPPRSQVHAWLLTANLFGHAPQAAPAARER
                     YSLGSALGQLASGRQGDGVKRRMEHLLAAEPTSLPYYLRQAVRLVYQAGIPLDFLKLLQ
                     DLVVLLSHGQDGQGSDGRDRLLLRWAAEYHGASRSEKNTEGSKEAELETDDDLNADDEA
                     L"
     gene            16812..18050
                     /gene="cas7e"
                     /locus_tag="O1M07_RS33100"
                     /old_locus_tag="O1M07_33095"
     CDS             16812..18050
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="cas7e"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490090.1"
                     /locus_tag="O1M07_RS33100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33095"
                     /product="type I-E CRISPR-associated protein
                     Cas7/Cse4/CasC"
                     /protein_id="WP_189862019.1"
                     /transl_table=11
                     /translation="MIIELHLLQSFPVSNLNRDDLGQPKTARFGAVTRARISSQSLKRA
                     ARDSLDKYGLNPEELGKRSKRHGEKAAEILVERGVGQDFDTACRVTELALKVLGFKLDD
                     KRRLSYLLFLLSTAPRALADACEEHWDTLVRELGKRDVELEKKTSGKTSKVKTEKEWIS
                     SLQKSPSGPLLSFKKATQDAFLQGSRQAVDIALFGRMIADHSDKNVIAASQVAHALSTH
                     GVTTDFDYFTALDDFSRGEEPGAGMVGTIEFNAACYYRYANLDLDQLRTNLWPTHKDTE
                     AVPDPDDLVARTVQAWLRAFIHAVPSGKQATMAARTVPETLFAVVRDHGAWNLANAFLK
                     PVTDANDLLAASTDRLLRRYAKIKSFYGDDQIRGSAFHTLADEVPDAANTHHSAVTCDE
                     FVQYILETAGCTR"
     gene            18047..18751
                     /gene="cas5e"
                     /locus_tag="O1M07_RS33105"
                     /old_locus_tag="O1M07_33100"
     CDS             18047..18751
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /GO_process="GO:0051607 - defense response to virus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cas5e"
                     /inference="COORDINATES: protein motif:HMM:TIGR01868.1"
                     /locus_tag="O1M07_RS33105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33100"
                     /product="type I-E CRISPR-associated protein Cas5/CasD"
                     /protein_id="WP_189862021.1"
                     /transl_table=11
                     /translation="MSVLLLTFDAPMQSWGQRSRSTFRDTASEPTKSGVIGLLAAALGI
                     ARDEDERIRQLAMLRMGVRVDQEGVRDVDYHTAQNVAKADSSGDQPVVSRRHYLADALF
                     LVALEEGKAQLHELHQALHSPHWPLYFGRRSFVPARPVVAPDPTAAICDLPLEEVLRTH
                     PWTGCGTPPTEHLRTVIDTTPTDPGAELRYDVPHSFRSHDRQYCARYVRTGHVPCTPPL
                     LPATPAESTKKP"
     gene            18923..19255
                     /locus_tag="O1M07_RS33110"
                     /old_locus_tag="O1M07_33105"
     CDS             18923..19255
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS33110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_33105"
                     /product="hypothetical protein"
                     /protein_id="WP_189862023.1"
                     /transl_table=11
                     /translation="MHHLVHLPLATDQKGSTDKGVEFLSDRPLDRLPVPEAAIGQDEQD
                     GKHPSGKVNDEPLSFHPRHRSYRTRDLYRRTLYLPDVHRALGTDHLTALGAYAHEHLNQ
                     PEGSPR"
     gene            19252..19926
                     /gene="cas6e"
                     /locus_tag="O1M07_RS33115"
                     /old_locus_tag="O1M07_33110"
     CDS             19252..19926
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="cas6e"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948468.1"
                     /locus_tag="O1M07_RS33115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33110"
                     /product="type I-E CRISPR-associated protein
                     Cas6/Cse3/CasE"
                     /protein_id="WP_189862025.1"
                     /transl_table=11
                     /translation="MSVWLTRIVPDPRSRDARRDLRGSQSAAGLHRRLMSLYPDSAGPD
                     PRARFGVLFRVDDTPTGPHILLQSTHEPDLTRLPGGYGQARTRPLDMLLDALRPGLTIR
                     YRCVASAVRKPSTTTRALYDLPAVVALKGTAADDWWLRQADAAGLKPLSVHSQPIDAAQ
                     AVRIPPGPGKEQRIRHARTRFEGTATIIEPDRLRTKITEGIGRGKAYGCGLLSIAPARE
                     TA"
     gene            19923..20917
                     /gene="cas1e"
                     /locus_tag="O1M07_RS33120"
                     /old_locus_tag="O1M07_33115"
                     /pseudo=""
     CDS             19923..20917
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004520 - DNA endonuclease activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /GO_process="GO:0051607 - defense response to virus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cas1e"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115036.1"
                     /locus_tag="O1M07_RS33120"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_33115"
                     /product="type I-E CRISPR-associated endonuclease Cas1e"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTQPTEPDTARTPADARRKLAAPTVAMLPRIADSLSFLYLDIVRI
                     HRTTPASAPKSPANATAPKPSTSPPPPSAASSWAPAPPSPPAPWPPSPATAPPA"
ORIGIN
        1 cgaccgtggt gaaggtgccg cgctgcggat gctcgacctc gaccaccatg ccgtcggcgg
       61 ccagcgaggg atcctcgatg atctccttgg tcgacaggat cggcccgcag gggatgtcgt
      121 gggcggtcag cctctccagc acctcccact tggggagcgt gctgctccac tcctcgatca
      181 gctggaacat cttcgacagc ttgggcagcc gggcctccgg cgtcgcccag tccgggtcct
      241 cggccagctc cggccggccg atcaactcgc tgagcggccg ccagccgacc ggctgcacga
      301 tcacatagac gtagtcgttg ggcccgccgg gcgcgcactt caccgcccag cccggctgcc
      361 cgccgccgct ggcgttgccg ctgcgcggca cctcgtcgcc gaagccctcg ttcggatact
      421 ccgtcaacgg cccgtgcgcc agtcgctgtt ggtcccgcag cttcacccgg cacaggttga
      481 gcaccgcatg ctgcatggcg acgttgaccc gctggccacg gccggtacgg gtgcgttgga
      541 agagcgcggc gaggatgccc gcgacgcagt gcaccccggt gcccgagtcg ccgatctgcg
      601 cgccggtcgc cagcggcggc ccgtcctcga acccggtggt cgccatcgcc ccgcccatgg
      661 cctgggccac cacttcgtac gccttgaagc cggtgtacgg gccctcgccg aagcccttga
      721 tgctggcgta gacgatccgc gggttgatct cctggatgcg ctcccaggtg aaccccatcc
      781 ggtcgaccgc gccgggcccg aagttctcca ccaggacgtc gctgcggccg atcagctcgg
      841 tcagcagctc ctttccccgc ggtgtcttgg tgttcagggt gatactccgc ttgttgcagt
      901 tgagcatcgt gaagtagagc gagtcggcgt ccggtacgtc ccgcagctga cggcgtgtga
      961 tgtcgccgcc gaccgactcc agcttgatca cgtccgcccc gagccaggcg agcaactgcg
     1021 ttgcggaagg cccggactga acatgcgtca tatcgaggac gcgaatgccg tcgagtgcct
     1081 tggacacggc cgactccctc ctacttgtac atggtctggt tcatcgttcc gggggcgtag
     1141 gcgtccggat cgatccacac gttgatcagc gagggcttcc ccgactcccg cgcccgccgc
     1201 agcgccggcc cgatgtccgc cgggtcccgg acctcctcgc cgtacccccc gagcaactgc
     1261 gcgaacttgt cgtagggcac atcgccgagg gtgttcccga cccgctcccg ctccgcgccg
     1321 tacttggccc gctgcccgta acggatctgg ttcatcgagg agttgttgcc gacgacgccg
     1381 acgaacggca ggtcgtagcg gaccagcgtc tcgaagtccc acccggtcag gctgaacgcg
     1441 ccgtcaccga agagcgcgac cacctccttc tccggcctgg cctgcttggc cgcgagcacg
     1501 aaggggatcc cgacgccgag cgtgccgagc ggaccgggat ccatccagtg cccgggcgcc
     1561 ttgggctgga cgacctgacc ggagaaggtg accacgtccc cgccgtcccc gatgtagatc
     1621 gaatcctcgg tcaggaactc gttgatctcg ctcaccagcc ggtacggatg gatcggacag
     1681 gcatccgacc gcaactgcgg caaccgcttc tcgaccgccg cctgctcggc cgcccgcagc
     1741 tcgtccagcc actccttgcg cttgccggca cccccgttga tccgcccgga cgccgcctcg
     1801 gtgaccgcct tcaacacgag ccccgcgtcg cccacgatcc ccaggtcgac gtcccggttc
     1861 ttgcccaccg tccggtagtc caggtcgatc tggaccaccg tcgcgtccgg cgacagccgc
     1921 ttgccgtacc ccatccggaa gtcgaacggc gtccccacga tcacgatcac atcggcgttg
     1981 gcgaacgcat accgccgcga cagctggaag tggtgcggat ccccgggcgg cagcgtcccg
     2041 cgcccggccc cgttcatgta cgccgggacg ttcagcgccc ggacgagctc caccgcggcc
     2101 tcgttcccgc gcgtcgtcca cacctggctg cccagcagga tcgccggctt ctccgcgcgg
     2161 atcagcagat cggccagccg ctggacgtcc tcggggtcgc cggccgagcg ggtcgaggcc
     2221 cggtagtgcc cggcccccgg cacccgggcc gcggccaccg gcaccttccc gtccagcaca
     2281 tcccgcggaa tctccaggaa cgacggtccg ggcgccccgt ggaagcactc ccggaacgcc
     2341 atcgagacca tgtccgcggc ccgcgcggtg tccgggacgg tggccgcgaa cttggtgatc
     2401 ggcgtcatca tctcgacgtg cggcaggtcc tggagcgacc ccatcttgtg ctgggtgcgc
     2461 gccccttggc cgccgatcaa cagcatcggc gactcggccc ggaaggcgtt ggcgacgccg
     2521 gtcaccgcgt ccgtcgtacc gggccctgcg gtgaccaccg cgcatccggg ccgccccgtg
     2581 atccgcgcgt acccgtccgc ggcatgcgcg gcgacctgct cgtgccgcac gtcgaccacg
     2641 tcgatcccct cgtcgacgca cccgtcgtag atgtcgatga tgtgcccccc gcaaagggtg
     2701 tagatcacct ccaccccctc cgccttgagc gccttggcaa ccaagtgccc accggaaacg
     2761 agaccggtgc cgccactccc gaccccccgg gcacccccgc cctcccgccc accccgagcg
     2821 agatccgcgt cccgaccgtc ttcaggcatg tacatcgctt cccttcaact caactctccg
     2881 ttgcgccgat cacctgcggg cgcactctgt gcagctgccg cgactcgtgc ggcgcatgcg
     2941 gctgatgcga ctcgtatacg gcttgtcctt cttcttctgc ctctccctct tcttcttctg
     3001 cctctccctc ttcgtttgca tctgcgccaa ccgccgctca tgtatacagc actcggaaga
     3061 ctgtatacag tcgtcagtcg acaaaagctg cacgaacccg ttatcccgca tcccccgacc
     3121 gttgtccagg ggaagcgcgg ggaagcgcga ggaacggcaa cgatcacgcc acccgtcggc
     3181 gccggccggt cggctgtcgc tccgcctgcg cgtcgctcgc cctgtgtccg gcccgcgtct
     3241 gtcctgtgcc tggccctcgc ccctgccctc ggcgctcgcc cctgcctccg cgcccatcgc
     3301 ctccgggtgc gggtccgcga cgggcgcact ctccgggcgc acgcggccca accgcctcgt
     3361 ccgcctatcc ctcctcaccc ataaacgcac cttatgtccg gcgcggatac gcaggtgaag
     3421 ggcactccga aaccttggta ttgttatcca tgtcgccgcg gggaacgccc cgcgaagacc
     3481 acctgagtcc gggtggcgga atggcagacg cgctagcttg aggtgctagt gccctttatc
     3541 gggcgtgggg gttcaagtcc cccctcggac actgaccaaa tccctacggt ttctctgaaa
     3601 ccgtagggat ttgtcgtttg ccgacgcgtg caggtcgggg gcgatcttgg cccggatggt
     3661 ctgctggccg ggggtatagg tgagctggag gccgagccgg cggtagatct cggctttgtc
     3721 gtcggggtcg gcttggcgga tgacggcggc gagatcgctg atggaacgga cgaggcgggc
     3781 gatctcgtcg cgggtcatgc gggccccggt gccatgggtg gctgtcgcgg tgcggaggtc
     3841 ggcttcggcg cgggctcgtt tggcctgggt ctcggcgatc cacttggtga tcacggtcgg
     3901 gtcggcaccg gcttcgagcg cggcgcgatg ggtggcgagc ttcgtatcgc agtcggcgat
     3961 cacggcacgg gcggcttcgg cggcagtggt ctgtgtggcg gtgtggcttt cggtggcggc
     4021 tgcggtggcc atgaggtcga tggtgtcgtc gaggcggtga ggctgaaata cgcgggtgag
     4081 ccagtcgtcg agggctgggg tgatccactt ctctcggagg tagacgttgc gggggtggtg
     4141 gatgcggttg gccagcgcgt actcctcggg gaaacggcag cggtagtagg cgtcgccgtg
     4201 ggaccactga ccctgcatcc gacgggtgca ggtgtggcaa gtgatccggc cgcgaaacag
     4261 gtacgggttg cgggtgcgat ggacggggtg ggcgctaccg gtgtgggcgc ggcggtgcag
     4321 catctgctgg gcggcggcga aggtgtcgtc gtcgatgagg ggggtgtgga cggtcttctt
     4381 ggagatgatc catttgtcct gggcgttcca gcgcatcgcg gtggtgtagc cgagggagac
     4441 gtcctcgatg tccaggagcg tctcgtaggt gctttgtcgg ttccagattt ggcggccggt
     4501 gtagcggggg ttggtcagga tggcgcggac ggcgctcttg gcccaggcac gggtgtcacg
     4561 gtgggggttg cgggcttggt cgtgggccga ggggctggag atgccgtctc gggtgagtcc
     4621 ttcggcgatg gcgaagatgc ccaggccgcg caggaactcg gtgaagatgc ggacgacgat
     4681 cggcgcggtt gcggggtcgg gttcgaggcc gtggaggcgt ttgccgtcgg cggccttggc
     4741 cgggttgggg tgcgggccca ggtcgcacag ccggtacccg tacgggggtc ggccgccgag
     4801 gtagcggcct tcggtgaggg cttgggcggc catggcggcg tggacgcgga ctttgatgcg
     4861 gttgcgttcg cccttggaca tgccgccgaa cacggacatg atcaggtcgt gggcctcgtt
     4921 gtccgcgtcg atgggaccgc cgacctcggg cacccatagc gggacgccgt agtgggcgaa
     4981 gagcgggaag gtgttgccga actgggcgcc gtagaaggca cgctgcggtt cgccgatgac
     5041 cacggcgtcg aagccgcggt ggggtctgcg agcgcggtga ggagactggc ggcgtggggg
     5101 cggcgtttcc agggcagggc acgggtctca ccgacgtcga aatactccgc cacgatcagc
     5161 cctccggccg gctcgatgag gctctgtgcg cgtcggagtt gccactgtcg ggaggcttcg
     5221 gggtcttggt ggtcttcggt ggagactcgt ccgcagaagg cgaacttcag ggccggccgg
     5281 gagcgtgtgc catccgtggc ctttgtggag gtgctggggg tggggtgcag ccatgggaga
     5341 gggggttcgt tgccggtcac ggtcaggtgt ctttcggttg gtggtcgggg tggccatcca
     5401 cggatagctc ggggcaggtc agagcgccag ctgggctggt tccggttgct ggggtgtggg
     5461 ggtgtgcgcg ggtggcgtgg cgggtgagga tgcgcagtag ggctgcggcg gctggcaggt
     5521 tcagctcggg ttcgggtggc gtgatgacta cgcggaagcc gtcaggcggc gtatcgcacc
     5581 gcgggcgcgg gctcacgagg ggcggagggg agaggaggag gtgtacatcg gtggtcggcg
     5641 cccggaggcc gggggagaaa ccgtctggtg ctgacatgaa gcgataggga ttcagcaacg
     5701 cggatttgtc acggccgtcg atcggcttcg cacagtcggc cgatccgggg gcggcagggc
     5761 cgttgaagcc gagcgccgag gagaaggcgg tctttggcca ggtcaccggg gcaacgggcc
     5821 agaggcgagc cacctgcgag ccaccgccga gccacccgcg ccggctccac aatcggccgg
     5881 aggaggcggc gggaattcag ccagatgggg cgcgacgagg cgtggttcag ctgacgcggt
     5941 gttgggagga tggggaagtt tgcggtgggc ctgacaaagc cgtcgccagg cggccagggc
     6001 acggaggccc aagccgcctg gctcctatac ccgacggagg ggactagcgg ccgtaacgac
     6061 cgcttcggct acaagtacgg gaacggaagg ctgttgtgtt ggatggcctg tgctctcgtg
     6121 gttgcgccgg ggcggcgcgc cgtagcttgt tgaagaccaa gacgtcctcg tgctggacga
     6181 cggagagcgg gatgccccct cggcgggcgt cgcggacgtt cttcatctgg aagaacgacg
     6241 ggcgggtgac caggtggctg ttgcggatgc cggcgaggag ggcgacgcac cgttccgatg
     6301 gtgtgagacc ggcggtcttg ccggcggcga ggacggcgga gggcaggtcg atgagttcgc
     6361 cgtgctcgcg ccaggggcgg gtggagacca cgaccgttcc gccgggacgc agcatggtgc
     6421 ggcactgggc gaggatctcg gtgaacgcct ccaggaggtg ggcagtgggg acgtgggcga
     6481 ggttggcgcg gtcgtggctg tagcggaagt ccttcttgac caccccgggt tcgccggtct
     6541 cccgggagga acggacctgc ccgtggacgc tgggcccgta gggcggtgag gtgactacga
     6601 gatcgacctc cccgcgagca tcggtggggg cgagggcggt gaggtggcgg gcgtcaccgc
     6661 agcggacgat gccggtaccc gtgccgcttt cctgcgaggc ggcgcgtgcg ttgagggagg
     6721 ccagggtggc ccactggggt tcgtattcga tgccgagggc gttgcggccg aggtggaggg
     6781 cttcgacgag ggtggtgccg atgccacaca tcgggtccag gaccagatca ccggggcggg
     6841 tgtaggtggt gatggcgtgg gcggcgatgc cggggtgcat cttggccgga tgggctgccg
     6901 agccgggaac gtagcggcct ttgcgcctgg cgggggcgga ggtgggggcg gtgttccaca
     6961 ccgagtcggg agaggacatg cgcggggctc cttcaggctc cggtggggtg aatggccgag
     7021 agggcgatca ggtcactgtg cgcgacacct ggactggcgt ccgcgggcgg gttgggaatg
     7081 aggtggtcgt cggcggggtg ggcgtgcgcg acgatgacgt gctgcaggta ccggaacccg
     7141 gcggtgcggg cgcaggcgat gagggagccg agtgggtcgg tgaggatgcc ctcgtcccgg
     7201 cgttggcgcg tggccagcag cagcagtccg tcggcgggca ggaggcggtg ggcgcggtgg
     7261 aagaagcctg gccagccgtc ctccatcgcg ccgggcatct cgctcatgcc accgtatgcg
     7321 ggggtgttgg tggggtcggg gagggtgtcg gggtggagtt cggcgagcag cagcgagagc
     7381 ttgctggggg tgccgtcggt gtaggtgatg acgggggtgc gggcgtccat gcccggctcg
     7441 gtgtcccgga tggagatctt gagcagtggt gcagggagtt gcccggcccg ggtggtgaac
     7501 acggtgcgga tccgctcgat ggcccagtcg ggcagcacgg tgcccgcagc cggtgcggcg
     7561 tgtggctcgt cgggagccgg aagccagatg gtcgtcggca acggacgtgc gctacgggga
     7621 cggacagtgt ccgcggccgg agtacggcgc gaggtaatgg acatcgacag atggcgcccg
     7681 gaaagcggga ccgaatccgt ccggtgctga cgtggcgtaa tagagggacg gccggccgga
     7741 tgtgtcgtcc gcggcgggag tgttcgatcc gttgttgcgg cagcagtctg ccccgtgccg
     7801 tcatgggcct gaccggctac ctggttgctt ttgcccagct cagccgtata acgagccagt
     7861 gccgagccac cagcgatcca ctgccgagcc accccgcagg caacccgatg cgcgtgctgg
     7921 gacagcacga agagttttct ctgttcgata tcaaaaggcg caactgcagt gcccgtgttg
     7981 gccatcggga acgggccgat gagcgatcgt tgtagcggtc cggctagagc acgggatcgg
     8041 tgcgcggtcg gtctgccgag tggcagggag gcggtctgag cgtgcggttg cctgctatgc
     8101 cagcccccgg cccaaccgca ccgcgcgctc cacggggaag taggcgccat cagggcggtc
     8161 gaggtcgagt tggacggtcg ggatcagcgg ggcctgggcc atgaaccgcg ggacagtgcc
     8221 gtggttgggc tgggcggcgt gaatcacgaa agggcggcag aggtaaacat cccccgccta
     8281 ggagcgtggg tcagtaacga gcaagcggct tcgctcgcgt gactggcggg gcggtcgcgg
     8341 cggccccgcc ggggcctgtg tggggctgtg gcgggggcct gcccgccggg ggtccggctg
     8401 tcagggctcg cggcgcggcc ggggaggccc ggctggtcag ccggccagag cgccgatccc
     8461 tgctgtcccg gcgtggcgga agatcttgcg gaggttgtgg caggcggcga gcaggcgcca
     8521 ctcgccgcgg gcgccgtcct cgccgcgcag gaggagctgg cggccgttct ggcaggtcat
     8581 gatctgtccg aagacgggtt cgacgatggc cttgcggcgg ctgtaggcct tccggccggg
     8641 cttggtccgc agcttgcggg ccatgcgctc cttcaaggtc gcgtccttgg ggatgcgtcc
     8701 gcgtggtgcg ggttggacct gctcgtcgtg gccgagccgg cccgtggcca tgaacgtgtc
     8761 ggcgccgcag gcaagttggc gctcccgtgc ggcttcgagg ttggtctcgg agcagtagcc
     8821 ggcgtcgacg agggcctgct tggggtggcg gccggtgttc tgcgcggact ggtcgagcat
     8881 cgtggtgtag ttcagcgcgt cggaggcatt ggtcatcacg tcggcggcgg tgatgacctg
     8941 gtgggcctcg tccacgacgg cctgggcgtt gtaggcctgg atgtacgcgc cgtcgctgtt
     9001 cttcatgatc cgcgagtcgg ggtcggtgaa gttggcctgg gccttcggtt tcggccgggc
     9061 cttggcggcg gcggcctcgc cggcgtcggt gacggcctgc tggtcgctgg tgccggtgcg
     9121 ctgccggcgg cggcgttcct tgtcctcggc gtggcggcgg gccttgtcgg cggcctcggc
     9181 ctcgatctgg gcgcgggcgg cctgcagcct ggcgaggcgc ttctcgcgcc ggtcgagttc
     9241 ggcgggcagg tccatgtcct tgccgtcgac gccgaaggtg gcgtcctcgg cttcgtcggt
     9301 ggcctcggcg tcggcgagca gggctgcggc cttcgcctcc agcgcggcga tctcggcctc
     9361 gacctgctct tccttgtcga cgaggcggcc gtagctcatc gccttgtgct tggaggcgtt
     9421 cgcttcgagc ttggtgccgt ccagggcgac gcggcccatc ttgaccatgc cgagcttggt
     9481 cgcgaggtgc agcgaatggg tgaacaggtc acccagggcg tcgaggtggc ggcggcggaa
     9541 ccgggcgatc gagcggaagt ccggggcctg gtcggcggcc aggaaccgga acgcgacgtc
     9601 gtcggagcac ttgcgctcga tcgcccgcga ggagcggacg ctggtggtgt agccgtagat
     9661 cagcaggcgc accatcagcc tggggtcata cggcgggtag ccccgcttct cggtgtagtc
     9721 ggccaggatc ggggagaggt tgagtacctc gtcgaccagg tccgccacga accgggcgag
     9781 gtggccctcg ggcagccagt cgtccagaga cggcggcagc aacaggacct gatgcggatc
     9841 gaacgtccgg aacgtcttgt ccaccgctgc cgcacgaccc ggtgaccgct tcacctcgat
     9901 cggctcgatc tcgaacagcc catcctcgcc acgcatatcg ggatcatccc gcacgaaaga
     9961 tcacgagacg caggcgggtc accgttgctg agacacgctc ctagcctcgt gtgggcgtgc
    10021 ctcgccacca ccacccgatc tggggaagcg tgcgggggtc gatggttcct tccgtcggca
    10081 tcgacgagag ccctgtgctg ccggggctcc tgccgacttc ggtgttgtac cgctcgttcg
    10141 tcaggcacca gtggaggttc ccgctcacga atgtgccgag ctgccgaagg tacagctgtt
    10201 ccaccactcc cggggtctgt cggcgtagct gcatgagcag caccataacg gcgtcgcgca
    10261 gtgccacggc ctcgaccagg gctcttcctc ggtcgcagtc gaggtggcgc atcagggcgt
    10321 tgacgaggtt gatttgttcg ctgccctggt cgacctcgcg gtcgaaggag aagatcgcgg
    10381 cgtcggcgct gaccaggaag tgggcagcct gcgtggccac ctgaagcggc ctggatgcga
    10441 ggagcacgtc gtcgggcaga gctgcaccgt tggcgatctc aaccagcgaa tagcagatct
    10501 tgataccggc gtcgcgatgg cccatgttga ggcagtcgcc gagcgagaag tggcgactcg
    10561 cggcacggta ggtgagcccg ctcagagcgc cgaggaacca ttcggtgtgc ccgtcgatcc
    10621 acctgcggac ggcgacggcg ccggcggcct tgcgcaggcg cctggacaga tcccggtacg
    10681 cggccggata gggactgttg gaggcgtcgg tggattccgg ggagtcgagt gcgcgcaaca
    10741 cctcgccgat catggacacg gatgcgtccg gctggcttcc actctcgtcc aggtggtcgt
    10801 catcgaagag gaagctcgcg tatgtccatt ctgctgcgag ttccaggagc tccgggtcgc
    10861 cgtcaggtgc gaggcggcag caccactgcg ctgacttgct gccgatgagg cgtcggcggc
    10921 ccacctcact ggtgccgagg ccaaactcct cggcccaggc aagcgcgcgg cgttcgatgt
    10981 cggcagcatg cgggtggatt gaggaaggga tggggcagaa cagtggcggg atgccgcggc
    11041 tctgcccggc cgtcgcgacg ggcggactcg gctctgcgtg cccggtaccg gccctcaggt
    11101 ccgccgccag ccggagggcc gcggtgccga taccgcgggg gcgtagcaga ccctcggaaa
    11161 gggcgctgcc ctgcatacaa ccattgccgg cgggcaaccc ttgctcgaac cgcacgtcct
    11221 gtgccccctc agctgtcgtg accctaccag cgcgatcact acccgtgatc aggccgcgtg
    11281 atacctggcc tgtcaccggg caaccgcgac cggtcccgcc cctcactgcc acccggccag
    11341 ttgccggtta ctgacccacg ctcctagcgc ggagaaagag ggcgaccgct ggtaccacgc
    11401 ctggctgtgt gccggttcac ctctgctggc gcggagaacg ggtccaacga agggcgcgtg
    11461 catgtggaga gcccgtccct ccgcgccccc cggacggggc cctggctcgc ttggcccccg
    11521 gattgcgcgg ggagcaagtt ctctgagttg aggtgatgtt atggcgttac cacttcgtgc
    11581 cctccgggct tcgctatccg tcccctgtct gtcgctgcgt ctggccacac ttggagtcta
    11641 tgtttgacat ccatcagggg gaccgcgagc cggacgtacg agcggcgtgg gcgaagctcg
    11701 ggacgaagag ggatgccgag ccgcacccct tgatttgcca cgcgctggac acggcagcgg
    11761 cagcgcaggt catcgctcag attttgtgcc gggggtgtgt gggggccagg ctgcggcgga
    11821 tgctggagcc cctggacgga tccgagctgt ggatctcggc actgtgcggg ctacacgacc
    11881 ttgggaagta ctcgccaacg tttcagagcc ttcggttgga cgtcgcagag ctgtatctgc
    11941 ctgaaacggc gcagcgagac atgcggtctc tggtgaaaaa caatcttgat ggtgctcgcc
    12001 aggacgtgca tcacggctgg tacaccactg tgcacatgca ggagctgttg ctgacgtggg
    12061 gggcgaagcc agacgtagcg cgggatatcg cgatcacgtt gggtggacac catggggtct
    12121 ttccccccgc cagcacacgg tcgaatgcca agaactcgct gggagagtct ggggctgccc
    12181 gctgggcttc ttggcgaacc ggtcttgtgg aggcctttct ccgagcatgg ggggtgaagg
    12241 cccatgaagc ggcgtggggg gaggttgagc gggatctggg tgccatggtg gtactggcgg
    12301 gtttgacaac cgcggccgac tgggtggcat cggaccggcg cggactggct gatgtgccga
    12361 cagatttcga tcttgagtcg tacgcagagg aagcccgtct gacggaggcc gggaagatcg
    12421 acgggatcgg gtgggaggca tgggtgccac cgcaggatgt gtcgttccgt ggtctgtttc
    12481 ccgacaagcg ggatgtgcgg ccggtacagg aggcggtgga gaagacggtc gcctcgctgt
    12541 cggggccggg gatcgtggtg atagcagctc cagcggggga ggggaagacg gaggccgggc
    12601 tgcaggccgc cacggccctg gtgaggaagt tgggcttggc gggcttctat gtggcgatgc
    12661 cgacacgggc cacgagcaat caaacgtacc gcagagctgc ggagttgctg gagagggtgg
    12721 gcgctgcgtc gcctcttcaa ttgctccact cctccgcagc cgaggtggtg gcggcggaac
    12781 ggaatcggag agaccggacc ggaacgctgc aacccagtgg aatagggccg gacacggaac
    12841 tgtcaacgga caccgtcgtg cgccaccagg atacgagccg ccaggacaaa gaggcgcgcg
    12901 gttggttcgc gcataagaag cgcgggttgc tgtcgccgac cggggtcggg accgtcgatc
    12961 agctcctgct cggcgcgttg cttggtcggc acaactttct gcgcctgacc ggtgtctcgg
    13021 gcaaggtggt gctcttcgac gaggtccaca catacgacca gtatcaactg gctctgctgg
    13081 agtcgctgct gaggtggctg ggctatctgc aggttccggt ggtactgcaa tccgccacgc
    13141 tctctgccca gctcagcaac aaactggtgg gctgctgggt caaagggtcg ctcacggcca
    13201 tggctccggc gtcggacagt cccgccccgg tatcgcttcc gacagcgttg ccgtatccgc
    13261 gggtcatgtg ggccgaggca tgtgctcctg aacctcaggt gaaacacgtt gccgcttccg
    13321 cgcttgcagt gaaccgtgtc tacgcactcc acatgccgga ggacctgtgc cgggacacct
    13381 gggggcagca cgtcgccgac gcgctggagc tggccgcacg ggaccagtgt gtcggggtct
    13441 tccacaatct ggccgcccag gttgaccgcg atgtcgaggt ggctggcaag gagatcggga
    13501 agcgtgctga ctggacgggg atcaagatct acgggctcca tgccgggatg gctgaccggg
    13561 agcgggcgct tgccgacacc atggtccgag aggcattcgg gccaccggac gatccagcca
    13621 cttcgcgccc tgcgcgggcg gttgtcttcg gcagcccttt gctcgctgag ggtgccgaca
    13681 tcgatttcga cgcagcgttg gtcgcgctgg ccccgattga ccgcatgctg caggccatgg
    13741 ggcgagtccg gcggcacgtg cgggacaggc cggtgggcgc tggccccatc ccgatctcgg
    13801 tgttcggtgt ctgggaggag accaaaaccg ctcggaacgg tcagaagacc gtaacggttc
    13861 acttcccgcg gttcaccact acggtgacca gtcacgccct tctgctgcgc acgtgggctg
    13921 tattgcggga cagatcacac atccgactgg acgacctcca gcagctgatc gacgccgtgt
    13981 acggggacga agactccatc gcttgccctg aggggtggga gacacagtgg cggacagcgc
    14041 atgccgcgat gcgtaagagc atcgacaaca aacgagtgaa ggcaagcgtc ggtgtgattc
    14101 cgctgccgcg cacagagctc agcctggagg aactgacacg ccctgcgacc acgtggcgcg
    14161 gcacccggct ctcgcacgac agcggttcgt gagtccgccg cctatcgcca gctggtgatc
    14221 ccagagagag atcgtgaaag cgccttctgt cgaaggaagt tgtgcgagac tagttggcct
    14281 tcccgggcag gagtgtcacg aaactgacgg gacagcgatc caagtattga agtgggtggg
    14341 gatcacgggg gtgtcgttca atctgctcca cgagccgtgg ctgccagtcg tccgattgga
    14401 tggctcttcg gcgaagctcg gcatcgttga ggtactgaag cagtccaaga tgttgcgcgg
    14461 actggtcggt gagacggcca cagtcagctc ggcacttcat cgcctgttgc tggcgtttct
    14521 ccaccggacg tttcgtcctg tggacgacgc ccaatggcgc agtctgtggc tggactcctc
    14581 cgggacaggg ttccccgagg aagagctcaa cgcctacgcg caagactggg cttcccggtt
    14641 cgatctcttt gatccggagg cgccgttctt ccagtgcccg gctgtgccgg cacctcggaa
    14701 gtggcggagt cctgcggtcc tggtgggatt tcgcgcccgc ggaaacaacg ccaccctgtt
    14761 cgaccacagc acagacagtg acaagctgcg gctcactccg gatgaggcgg cacgctggct
    14821 ggtgacgacc caggcgtacg acaccagcgg caagaagacg ggctacgacg gcaccggcaa
    14881 cccctcaggc gaatcaccgc cgacggcgcg gttcggctgc gtactcgtcg aggccgacac
    14941 gctgtaccgc accttgatgc tgaacctgct ggactacgac cccgccgatc gccgtccccg
    15001 tccaactcag ccagacgatt gtcccgtgtg ggagcggcct gcatcggagt cggagaacga
    15061 gaacggccag cgcctaccgc gtggctggac ggacgttctc acctggccat cacgccgcat
    15121 ccgtctttcg cacactacgg tgaacggcca gcatatggtc gacggcgtga tcgtctctcc
    15181 cggcagttcg tgcaacctgc cgatccggga ctacgaacat atggcggcgt tccgggcacc
    15241 gtggttcgcc gagacggcct cgggctcaag ccgggcagcg gtacccatgc ccgtccgcct
    15301 ggacatcatg cgaggtgtgt ggcggcacag ccaggagctg ctgctgccac ctgagcgacg
    15361 ctggtggaag acgtatcgaa gcaccgggct caagctcagc gagacggggt tcccggagga
    15421 agaaccgcaa cggttgcgac ccgcagctct ggagcacctc gcacatctcg ccgacgacgg
    15481 ggccttgccc aaggacgccg tctacaccct acgggtcttc ggtcagcagg tggggtcggg
    15541 gggaagcggc tccatcgcgg cttggtgtga ggaggtggtt ccagcaccgg tcgcgttgct
    15601 gcgcgcgcgg aacccgcgca tcgggctgct tatcgggagc gcggtggccc tcgccgacga
    15661 tctcggctcc atccttcgtg cgttggaacg cggattcagg caggagtttg atgagcagtt
    15721 caccctcaag gaggaggaca agagggagaa ggccggattt cggtaccagt ccgagcttcg
    15781 ctactggccc cggctgccca catccttcgc cgaactactc cgcaacctcg cactgttgga
    15841 gaatatcgag cccggcaact accttgcgga ggcggagcac gaagccctgg acaagtggcg
    15901 ccgacaggca gtccgcgcag ctgatatggc cgccgagcag tggctgcggc agcagacacg
    15961 cgctggccgc accctcctgg acgccagcgc ccaccacgag cgctaccgcg cgaactgcaa
    16021 gaacgccacc cgtgtgctcg cccgggctgt agccgcacgg acccctccgg aggaagcatg
    16081 accgagcagt ccaccagcac cacgcccgcg agccgagtac cgcgcgagcg gcaggaggcc
    16141 ttcgtacgct ccctctatgc gctggcacca ggtcaaaggc tcggtagcga tgggcaagac
    16201 gcgacgcaag gcacagcccg cgacgtcttg gcccacctac ggcgcagcgc gacgcaggac
    16261 caacccaact tgaccgtctg ctcgctggtc ttcgaacacg atccgccgcg atcccaggta
    16321 cacgcctggc tgctcacagc gaacctcttc ggacatgccc cccaagctgc cccagctgct
    16381 cgggagcgct actcgctcgg ctccgccttg ggacaactgg ccagcggccg gcaaggtgac
    16441 ggcgtgaagc ggcggatgga acacctgctg gcagcagagc ccacgagcct gccttactac
    16501 ctgcgccagg ccgtacggct cgtgtaccag gccggcatcc cgctggactt cctcaagctc
    16561 ctccaggact tggtggtgct cctttcccac ggacaagacg gacagggctc cgacggcaga
    16621 gaccggctgc tgctgcgctg ggcagcggag taccacggtg ccagccgatc cgagaagaac
    16681 accgaaggaa gcaaagaagc cgaacttgag accgacgacg acctgaatgc ggacgacgag
    16741 gccctgtagc ccaaccacga cgtgcgcgct ccgcggactc atcggccgca caaccgatat
    16801 cggagattac gttgatcatt gagctccacc tgctgcagtc cttcccggtg agcaatctga
    16861 accgggacga cctcggccag ccgaagacag cccgcttcgg cgctgtgacc cgggcccgga
    16921 tctccagcca gtccctcaaa cgcgcggcac gtgacagtct cgacaaatac gggctgaacc
    16981 cggaagagct gggtaaacgc tccaagcggc acggtgagaa ggcggccgag atcctcgtcg
    17041 agcgcggggt tggccaggac ttcgacacag cgtgcagggt caccgaactt gccttgaagg
    17101 tcctgggctt caaactggac gacaagaggc gtctgtccta cctgcttttc ctcctctcga
    17161 ccgcgcctcg agcacttgcc gatgcctgcg aggagcactg ggatactttg gtgcgcgaac
    17221 tcggcaagcg tgacgtggag ctggaaaaga agacgagcgg caagacatcg aaggtcaaga
    17281 ctgagaagga gtggatcagc tccctgcaga agtcgcccag tgggcctctg ctttccttca
    17341 agaaggcgac ccaagatgcc ttcctccaag gaagccgcca agccgtcgat atcgcccttt
    17401 tcggccgcat gatcgccgac cactcggaca agaacgtcat cgcagccagc caggtcgccc
    17461 acgcactgtc aacacacggc gtcaccactg acttcgacta tttcaccgcc ctcgacgact
    17521 tctcccgagg ggaggaacct ggcgctggca tggtcggcac cattgagttc aacgccgcct
    17581 gctactaccg ctacgccaat ctcgacctcg accagctgcg cacgaacctt tggccgactc
    17641 ataaggacac agaggcggtt cccgaccctg acgacctggt ggctcgcacg gtacaggcct
    17701 ggctgcgggc tttcatccac gcagtaccga gtgggaagca ggcgaccatg gccgcccgca
    17761 cggtgcccga gaccctcttc gccgtcgttc gcgaccacgg cgcctggaac ctcgcaaacg
    17821 ccttcctcaa gccggtaact gacgccaacg acctcctggc cgcctccacc gatcgactgc
    17881 tgcgacgcta tgccaagatc aagagcttct acggcgatga ccagatccgc ggctctgcct
    17941 tccacaccct cgccgacgaa gtccccgatg ccgccaacac ccaccactcc gctgttactt
    18001 gcgacgagtt cgtccagtac atcctcgaaa ccgcggggtg cactcgatga gtgtgctcct
    18061 gctgaccttc gatgctccca tgcagtcctg gggccagcgg tcgcgctcca ccttccgtga
    18121 caccgcgagc gagcccacca agtccggtgt catcggcctg ctcgccgctg ctctcggcat
    18181 cgcacgcgac gaagatgagc gaattcgcca gctcgcgatg ctacggatgg gggtccgcgt
    18241 agaccaggaa ggcgtccgcg acgtggacta ccacaccgcg cagaacgtcg cgaaagccga
    18301 tagctcgggt gaccagccag tggtctcccg ccgccactac ctcgccgacg cactctttct
    18361 cgtcgcgttg gaggagggga aggcacagct gcacgagctc caccaggccc tccactcacc
    18421 gcactggccg ctctacttcg gccgccgttc gttcgtcccc gcccgccctg tcgtcgcccc
    18481 cgaccccaca gccgccatct gtgacctccc gcttgaggaa gtcctgcgca cccacccctg
    18541 gaccggctgc ggcaccccgc ccaccgaaca cctacgcacc gtcatcgaca ccacccccac
    18601 ggacccgggt gccgaactcc gctacgacgt cccccactcc ttccgttctc acgaccggca
    18661 gtactgcgcc cgctacgtcc gcactggcca cgtgccctgc acccccccac tgcttccagc
    18721 tacgcccgct gaatcaacaa agaagccatg atgactacgc tattcaccac ccccagcctc
    18781 tggttcgccc acatcctcct ggccccgcgc aaacccgcgg tccgccgtga cccagccagc
    18841 ggcatcgccc tcttcactcg cccctcatga gcttcttcct caacgacctc ggcacccacg
    18901 ctcgccaagc ggccggaccc ccgtgcacca cctggtgcac ctgcccctcg ccaccgatca
    18961 aaagggcagc acggacaagg gagtggagtt cctctccgac cgcccactgg accgcctccc
    19021 cgtcccggag gcagccatcg ggcaggacga acaggacggc aagcacccct cgggcaaggt
    19081 caacgacgaa cctctctcct tccacccgcg ccaccggtcc taccgcaccc gcgacctcta
    19141 ccggcgcacc ctctacctgc ccgacgtcca ccgcgcactg ggcaccgacc acctcaccgc
    19201 actcggcgcc tacgcccacg agcacctcaa ccagcccgaa gggagccctc gttgagtgtc
    19261 tggctgaccc gtatcgtccc cgatccacgc tcccgtgacg cccgccgcga cctgcgagga
    19321 tcccaatccg ccgcgggact gcaccgccgc ctgatgtccc tgtacccgga cagcgccggc
    19381 cccgacccac gcgcccgctt cggtgtcctc ttccgcgtcg acgacacccc caccgggccg
    19441 cacatcctcc tgcaaagcac ccacgaaccc gacctcaccc gtctccccgg cggctatggc
    19501 caagcccgca cccgccccct cgacatgctg ctggacgccc tgcggccggg cctgaccatc
    19561 cgctaccgct gcgtggccag cgccgtccgc aaacccagca ccaccacccg agccctctac
    19621 gacctacccg ccgtcgtcgc actcaagggc accgccgccg acgactggtg gctacgccaa
    19681 gccgatgccg ccggcctcaa acccctcagc gtccactccc aacccatcga cgccgcacaa
    19741 gccgtacgca taccccccgg cccgggcaag gaacaacgca tccgccacgc ccgcacccgc
    19801 ttcgagggca ccgccaccat catcgaaccc gaccgactcc gcaccaagat caccgaaggc
    19861 atcggccgcg gcaaggccta cggctgtggc ctgctgagca tcgcccccgc acgggagacg
    19921 gcatgaccca acccaccgaa cccgacacag cacgcacccc cgccgacgcc cgacgcaaac
    19981 tcgccgctcc caccgtcgcc atgctgcccc gcatcgccga ctccctctcc ttcctctacc
    20041 tcgacatcgt ccgcatccac aggacgacac cggcgtctgc gccgaagtca ccagcgaacg
    20101 ccacggcacc gaaaccctct acctccccac cgccgccctc agctgcgtcc tcctgggccc
    20161 cggcacctcc atcaccgccc gcgccctggc caccctcgcc cgcaacggca ccaccggcct
    20221 gatcaccggc tccggcggcg tccgctgcta cgccgccgcc ctccccgact ccctcaccac
    20281 cacctggctc gaacgccaaa cccgcacctg ggccgacgac aaccaacgcc tcgccatcgc
    20341 caccgcgatg tacgaaaaac gcttcggcaa aagcactgtc ccacccggca ccaacctcac
    20401 ccaactccga ggcatggaag gccaacgcgt caaagcccac taccgcctcc tcacccagca
    20461 acacaagatc ggccgcttcc gccgcgccta cgaccccgcc tcctgggaca cccaggaccc
    20521 cgtcaacctc gccctctcct cagccaacac atgcctgtac ggcatcgtcc acgccgccat
    20581 cctcgccctc ggctgctccc cggccctcgg ctacgtccac cagggcaacc aacaagcctt
    20641 cgtctacgac atcgccgacc tctacaaagc cgacctgacc atccccctcg ccttctccct
    20701 ccacgcctcc accaaccccg aagccgcagc ccgccgctcc ttccgcgatg gcctgcggct
    20761 gttcaaactc ctgccacgca tcgtcgccga catccaggaa ctgctcgacc ccgacaccaa
    20821 acgcgacgtc cccgacccgg aagaacaact cgtcgacctc tgggacccca tcgccggagt
    20881 catccccggc ggcacgaatc acgcaacgga cgcatgacca cgccgacaac ggaacacagc
    20941 ccatggcctc aatgatcgtg ctctccacca cagccgtccc cgaccacctc cgcggagccc
    21001 tcacccgctg gctcctggaa gtcaccccgg agctctacgt cggcaccgtc tccgcccgcg
    21061 tacgcgacga gctttggacc gccgtggccg catgcacagg cgacggcatg tcagtcctcg
    21121 cctaccccag caacaacgaa caaggctttg aactccgcac cgcgggaaca cgacgccggc
    21181 acccggtgga cttcgacggc ctgaccttga tcgcc
//
