LOCUS       NZ_JAPTYM010000001     20684 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6555248
            Orig. end                         :: 6575932
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20684
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="26"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20684
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20684
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10684](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10684
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            976..2001
                     /locus_tag="O1M07_RS29020"
                     /old_locus_tag="O1M07_29015"
     CDS             976..2001
                     /EC_number="7.4.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087277.1"
                     /locus_tag="O1M07_RS29020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29015"
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="WP_229921353.1"
                     /transl_table=11
                     /translation="MLRVRGLVRHFPITKGLLKRKVGAVQAVDGIDFDVFPGETLGVVG
                     ESGCGKSTMGRLITRLDEPTGGSVEFEGQDITHLSPGRLRPLRRDIQMIFQDPYGSLNP
                     RHTIGGIVSTPFRLQGVEPEGGVKKEVQRLLELVGLSPEHYNRYPHEFSGGQRQRIGIA
                     RALALKPKLVVADEPVSALDVSIQAQVVNLMDDLQEELGLTYVIIAHDLSVIRHVSDRI
                     AVMYLGKIVELADRDSLYASPRHPYTRALLSAVPVPDPKRRTQRGRILLKGDVPSPIDP
                     PSGCRFRTRCWKATEECTTTEPPLIRLRTGHQVACHHPEGESDNSGAATESSDGKASTG
                     Q"
     gene            2101..3510
                     /locus_tag="O1M07_RS29025"
                     /old_locus_tag="O1M07_29020"
     CDS             2101..3510
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571843.1"
                     /locus_tag="O1M07_RS29025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29020"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_189854607.1"
                     /transl_table=11
                     /translation="MALSRSARRSSRWLALATAVASAATIAAAPAATPGAPGIGDPYFP
                     GLGNGGYRPLHYDLGVSYHPDSGRLDGRTTLTARATQDLSSFDLDLQKLTVDQVRVDGR
                     PARFSRTGDELVIRPGRPLARGERFAVTVVYHGVPRPLSGPIVFGSQYGWMKTKDGVFV
                     ACEPNAASTWFPSSDHPDEKATYDIRIDAPKGLTGVSNGRLVGSGEHGDRAWFHWRESR
                     PMAPYLATATIGKFDVRTGTTPGGTPIYVATDPTLPTGKVDVYGVTAAATDYWSKVFGP
                     YPFEETGAIVDDMPQAGFSLEVQSKPAYSAVRSESTIVHELAHQWFGDSVSVRQWKDIW
                     LNEGFATYAQWLWAEHQGTTTAHDAFRKAYQGIPADDAFWKIKVSDPQRDTMFSDAVYE
                     RGAMTLQALRERIGDQAFFRLLPAWTARHRYGNADTADFVALAEKVSGQRLGDLFHTWL
                     DTQSRPALSGE"
     gene            complement(3515..4147)
                     /locus_tag="O1M07_RS29030"
                     /old_locus_tag="O1M07_29025"
     CDS             complement(3515..4147)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602976.1"
                     /locus_tag="O1M07_RS29030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29025"
                     /product="trimeric intracellular cation channel family
                     protein"
                     /protein_id="WP_067346773.1"
                     /transl_table=11
                     /translation="MLHVLYLIGVAAFAASGVLAAYRANMDPFGGLVLAFAASISGGTL
                     RDLILDRRPLYWTHDWVLLTVIICVGVGTIVYLRFWSLPRKSLLVVDAIGLSVVTVIGA
                     RAAISAGATPLAVIILAVLTGVAGEVIRDVLCGEFPPLLLREDVYAIAALAGACCYLLM
                     DRLGAGANPAAVVSAGLVFALRMGALYLGLHLPRPQQLSGRGREDAG"
     misc_feature    complement(4238..4253)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.4"
                     /tool="antismash"
     gene            4264..5112
                     /locus_tag="O1M07_RS29035"
                     /old_locus_tag="O1M07_29030"
     CDS             4264..5112
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571841.1"
                     /locus_tag="O1M07_RS29035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29030"
                     /product="thioesterase family protein"
                     /protein_id="WP_067346771.1"
                     /transl_table=11
                     /translation="MASVTVGNSEFDRDTAVTRSAPGVYDAHLSEGWTIINAVNGGYLL
                     ALMGRALGDALPHPDPLTVTAHYLTASVPGPAVVRTEVIRTGRTLSTGTASLVQFADDG
                     SEVERMRVLATYGDLATLPDDVRTTAKPPAIPPYEHCLGTDSAPDGRPAIPGSTAIAGR
                     LDLRLDPATVGWAVGAPSGKGEMRGWFGLADGRDPDPLSLLLTVDALPPTAFELGLRGW
                     VPTVELTCHVRHRPAPGPLRVAITTRNLAGGFLEEDAEVWDSEDRLVAQSRQLARTILV
                     Q"
     gene            5318..6487
                     /locus_tag="O1M07_RS29040"
                     /old_locus_tag="O1M07_29035"
     CDS             5318..6487
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (1-372). E-value: 1.7e-71.
                     Score: 233.0. Matches aSDomain:
                     nrpspksdomains_O1M07_RS29040_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966104.1"
                     /locus_tag="O1M07_RS29040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29035"
                     /product="cysteine desulfurase family protein"
                     /protein_id="WP_067346769.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.2e-65, bitscore:
                     220.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVYLDHAATTPMLPEAVQAMTAQLTVTGNASSLHAAGRRARRTVE
                     EARESLAASLGARPSEVVFTAGGTEADNLAVKGLYWSRRAADPARTRILVSPVEHHAVL
                     DAVEWLAEQEGATVDWLPVDHHGRVHAEALREAIARNPADVALATVMWANNEIGTVQPI
                     RELAEVAREFAIPLHADAVQAVGQLDVDFAASGLAAMTVSGHKIGGPYGIGALLLGREH
                     APVPVLHGGGQERHVRSGTLDTPAIAAFAAAGRHAVAHREEFAREIGALRDDLIKAVRA
                     AAPDAVLGGDPDPAGRLPANAHFTFPGCEGDSLLLLLDAQGIACSTGSACTAGVAQPSH
                     VLLATGMSQDLARGTLRFSLGHTSTAKDVAALAEVIGPVVERARGAGLS"
     aSDomain        5321..6433
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1M07_RS29040_Aminotran_5.1"
                     /evalue="1.70E-71"
                     /label="O1M07_RS29040_Aminotran_5.1"
                     /locus_tag="O1M07_RS29040"
                     /protein_end="372"
                     /protein_start="1"
                     /score="233.0"
                     /tool="antismash"
                     /translation="VYLDHAATTPMLPEAVQAMTAQLTVTGNASSLHAAGRRARRTVEE
                     ARESLAASLGARPSEVVFTAGGTEADNLAVKGLYWSRRAADPARTRILVSPVEHHAVLD
                     AVEWLAEQEGATVDWLPVDHHGRVHAEALREAIARNPADVALATVMWANNEIGTVQPIR
                     ELAEVAREFAIPLHADAVQAVGQLDVDFAASGLAAMTVSGHKIGGPYGIGALLLGREHA
                     PVPVLHGGGQERHVRSGTLDTPAIAAFAAAGRHAVAHREEFAREIGALRDDLIKAVRAA
                     APDAVLGGDPDPAGRLPANAHFTFPGCEGDSLLLLLDAQGIACSTGSACTAGVAQPSHV
                     LLATGMSQDLARGTLRFSLGHTSTAKDVAAL"
     gene            complement(6542..7336)
                     /locus_tag="O1M07_RS29045"
                     /old_locus_tag="O1M07_29040"
     CDS             complement(6542..7336)
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539210.1"
                     /locus_tag="O1M07_RS29045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29040"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_372516375.1"
                     /transl_table=11
                     /translation="MEGVGEVEGVRGVEDTAADDARDAERTAPGPADGAADDTKRAGKR
                     LTRRRVLLLGGGAAVAAGAAAVAAREELAYWWGQLPGNSRPRKEGEVDFAGAQWSAASP
                     ANYRQANRPDDHTVDRVVIHVVQGSFATALKVFRDPFHEASAHYVVRGDGHIAQTVREL
                     DVAFHAGNRGYNERSVGIEHAGFVDRPESFTPDMYAASARLTAGICRRYDFPADREHIV
                     GHIEVPGTDHTDPGPHWDWDRYLTLVRAELRRPAARTRPDGP"
     gene            7382..8509
                     /gene="mnmA"
                     /locus_tag="O1M07_RS29050"
                     /old_locus_tag="O1M07_29045"
     CDS             7382..8509
                     /EC_number="2.8.1.13"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016783 - sulfurtransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571838.1"
                     /locus_tag="O1M07_RS29050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29045"
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="WP_189854609.1"
                     /transl_table=11
                     /translation="MTDAAAPRRLRVLAAMSGGVDSAVAAARAAEAGHDVTGVHLALSE
                     NPTSFRTGARGCCTIEDSHDARRAADVIGIPFYVWDLAERFREDVVEDFIAEYEAGRTP
                     NPCLRCNEKIKFAALLDKALALGFDAVCTGHYAQVILREDGSRELHRATDMAKDQSYVL
                     GVLDDRQLAHAMFPLGDTPTTKTEIREEAARRGLFVAKKPDSHDICFIADGDTQGFLAK
                     RLGSAEGDIVDESGTKLGTHEGAFGFTIGQRKGLRIGTPAADGKPRYVLDISPVNNTVT
                     VGPVESLDVTALTAIKPRWCGRPPADGPAVYTAQLRAHGGETEVTAEVVGEELRVSFTE
                     PVRGVAPGQAVVLYDGTRVVGSATIATTRRAAPVA"
     misc_feature    8771..8786
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    8771..8791
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.15"
                     /tool="antismash"
     misc_feature    complement(8828..8842)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.44"
                     /tool="antismash"
     misc_feature    complement(8835..8849)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.91"
                     /tool="antismash"
     misc_feature    8842..8856
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.48"
                     /tool="antismash"
     gene            9061..9651
                     /locus_tag="O1M07_RS29055"
                     /old_locus_tag="O1M07_29050"
     CDS             9061..9651
                     /EC_number="1.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159: dihydropteridine reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572569.1"
                     /locus_tag="O1M07_RS29055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29050"
                     /product="nitroreductase family protein"
                     /protein_id="WP_067346766.1"
                     /sec_met_domain="PF00881 (E-value: 6.3e-13, bitscore: 48.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAHSSSESPPESLPDAWTVLKTRTAVRNYAKEPVDDALIEQLLE
                     AMLAAPTASNRQAWSFMVVRRPAAVRRLRAFSPGVLGTPAFFVVACVDRSLTDNLSPKL
                     SQKIYDTSKLCVAMAVENLLLAAHAAGLGGCPVGSFRSDIVTSMLGIPEHIEPMLVVPI
                     GRPATALVPSQRRAKNEVVNYESWGNRAAAPTA"
     gene            9611..9928
                     /gene="albB"
                     /locus_tag="O1M07_RS29060"
                     /old_locus_tag="O1M07_29055"
     CDS             9611..9928
                     /codon_start=1
                     /gene="albB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_039632579.1"
                     /locus_tag="O1M07_RS29060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29055"
                     /product="albonoursin biosynthesis protein AlbB"
                     /protein_id="WP_039632579.1"
                     /transl_table=11
                     /translation="MNPGETVLPPQLREEIALLAVYLLSSGRGLLEEPADYGIYRCTDG
                     ARRALQLLDEHGGSTARLTAVRERLDEVMFAPMGEDRDMGAILDDLCRQMADALPEIET
                     P"
     gene            10001..10684
                     /locus_tag="O1M07_RS29065"
                     /old_locus_tag="O1M07_29060"
     CDS             10001..10684
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="O1M07_RS29065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29060"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_268253847.1"
                     /sec_met_domain="CDPS (E-value: 1.8e-66, bitscore: 223.0,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREEILGDRSRMIRQRGEHALIGISAGNSYFSQKNTVMLLQWAGQ
                     RFERTDVVYVDTHIDEMLIADGRSAQEAERSVKRTLKDLRRRLRRSLESVGDHAERFRV
                     RSLSELQETPEYRAVRERTDRAFEEDAEFATACEDMVRAVVMNRPGDGVGISAEHLRAG
                     LNYVLAEAPLFADSPGVFSVPSSVLCYHIDTPITAFLSRRETGFRAAEGQAYVVVRPQE
                     LADAA"
     gene            10855..11583
                     /locus_tag="O1M07_RS29070"
                     /old_locus_tag="O1M07_29065"
     CDS             10855..11583
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003984978.1"
                     /locus_tag="O1M07_RS29070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29065"
                     /product="VC0807 family protein"
                     /protein_id="WP_189854610.1"
                     /transl_table=11
                     /translation="MTQAATATATTSQGRTLLRSLTPLIVDAAIPLGSYFLLAEGFGMS
                     TVAALAWSSVVPALRTIWGLVRERTVNGLALLILVVNVVGLATSTLTGDARLMMAKDSG
                     VSSVVGIAILLSVRGRRPLMTAGLRPWVTKGSPEGNAAWDRLWARSARFRQLERRFSTV
                     WGSALLIECVVKVVGAYVLPVHTMVWLGTVLTVVAILLAMVVAGGGSAEPMEQMVKAEV
                     GAAGEAAEAGNAEPAPAAAA"
     misc_feature    11637..11651
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            11771..13147
                     /gene="gdhA"
                     /locus_tag="O1M07_RS29075"
                     /old_locus_tag="O1M07_29070"
     CDS             11771..13147
                     /EC_number="1.4.1.4"
                     /GO_function="GO:0016639 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gdhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539207.1"
                     /locus_tag="O1M07_RS29075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29070"
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="WP_189854612.1"
                     /transl_table=11
                     /translation="MSTVHTGVTQSGLTAELASLHAELVRRNPGEAEFHQAALEVLETL
                     SPVLTARPEFADAKVLERIVEPERQIMFRVPWQDDSGKIRVNRGFRVEFNSALGPYKGG
                     LRFHASVNLGIVKFLGFEQIFKNALTGLNIGGGKGGSDFDPHGRSDAEVMRFCQSFMTE
                     LHRHLGEHTDVPAGDIGVGGREIGYLFGQYRRITNRWEAGVLTGKGLAWGGSKARTEAT
                     GYGNVLFTEEMLKQRGEELDGQQVVVSGSGNVAVYTVEKAQALGANVLTVSDSGGYVVD
                     EKGIDLALLKQIKEVERGRVADYAQRRGSSAKYVAGGSVWDVACDVALPSATQNELDAD
                     AARILVRNGVKAVSEGANMPTTPEAVALLKEAGVAFGPGKAANAGGVATSALEMRQNSA
                     REAWSFERAEGELAAIMRGIHDTCHQTAERFGRPGDYVAGANIAGFERVADAMLDQGLI
                     "
     gene            13414..13956
                     /locus_tag="O1M07_RS29080"
                     /old_locus_tag="O1M07_29075"
     CDS             13414..13956
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009691 - cytokinin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lysine_decarbox"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539206.1"
                     /locus_tag="O1M07_RS29080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29075"
                     /product="TIGR00730 family Rossman fold protein"
                     /protein_id="WP_189854614.1"
                     /sec_met_domain="Lysine_decarbox (E-value: 5.6e-34,
                     bitscore: 116.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNICVFCSAADLDDRYVVPAREFAESIGRGGHALVWGGSDTGLMK
                     VMADGVQEAGGKLLGVSVEFLADKARANADEMVVTKDLAERKAQLLARADAIVVMVGGT
                     GTLDEATEILELRKHGMHSKPVVLLNTAGFYDGLKAQFERMEAEGFLPVPLSELVFFAE
                     DGAAALAHLEALAGAAG"
     gene            13991..14680
                     /locus_tag="O1M07_RS29085"
                     /old_locus_tag="O1M07_29080"
     CDS             13991..14680
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (1-172). E-value: 2.7e-12. Score:
                     38.9. Matches aSDomain:
                     nrpspksdomains_O1M07_RS29085_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602956.1"
                     /locus_tag="O1M07_RS29085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29080"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_039632571.1"
                     /sec_met_domain="adh_short (E-value: 3.1e-29, bitscore:
                     101.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTHLITGAGSGIGAAVARRLAERGEELWLLARDVGRAKELAERF
                     PGAHTLVGDLATPEKLDWALGHQRLPERLDSIQHIAGVIELGAVGDLPAKAWQRQLAVN
                     LVAPAEITRLLLPLVRIAKGDVVFVNSGAGLTANPNWGGYAASKHGLKALADALRAEEH
                     DNGVRVTSIYPGRTATPMQESTHRQEGKAYDASRWIDPESVATAILTAIDLPRDAEIKD
                     LVVRPGR"
     aSDomain        13994..14506
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1M07_RS29085_PKS_KR.1"
                     /evalue="2.70E-12"
                     /label="O1M07_RS29085_PKS_KR.1"
                     /locus_tag="O1M07_RS29085"
                     /protein_end="172"
                     /protein_start="1"
                     /score="38.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GTHLITGAGSGIGAAVARRLAERGEELWLLARDVGRAKELAERFP
                     GAHTLVGDLATPEKLDWALGHQRLPERLDSIQHIAGVIELGAVGDLPAKAWQRQLAVNL
                     VAPAEITRLLLPLVRIAKGDVVFVNSGAGLTANPNWGGYAASKHGLKALADALRAEEHD
                     NGVRVTSI"
     CDS_motif       13997..14065
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O1M07_RS29085_0001"
                     /evalue="2.40E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="O1M07_RS29085"
                     /protein_end="25"
                     /protein_start="2"
                     /score="23.4"
                     /tool="antismash"
                     /translation="THLITGAGSGIGAAVARRLAERG"
     gene            14771..15229
                     /locus_tag="O1M07_RS29090"
                     /old_locus_tag="O1M07_29085"
     CDS             14771..15229
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571833.1"
                     /locus_tag="O1M07_RS29090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29085"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_229921327.1"
                     /transl_table=11
                     /translation="MTTSRATTEAKTTAAAGCGFREIRGLVTELSRRLDAHQRSRIAEL
                     DLTPTQAKALEELGEPKTARELAAVLCCEPPNVTYVISKLEKQGMVVRRPHPADGRAKQ
                     LVLTEAGRELRLDLLRRMGTESPLDHLSHEERSGLRDELLRALGRVAG"
     misc_feature    15387..15402
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.92"
                     /tool="antismash"
     misc_feature    15419..15439
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     gene            15441..16841
                     /locus_tag="O1M07_RS29095"
                     /old_locus_tag="O1M07_29090"
     CDS             15441..16841
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571832.1"
                     /locus_tag="O1M07_RS29095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29090"
                     /product="MFS transporter"
                     /protein_id="WP_189854616.1"
                     /transl_table=11
                     /translation="MITENAAPRATASTPTRPAPAGGAAQLVVLALGFVMASLDTGIMN
                     VAAHDLRARLGLTMSGLTWVVDGYVLAFAALLLLAGSLAKRFGARRTYLVGLAVFTAAS
                     LLGAAAPGGGALVAARFAQGAGAALFMPSSLSLLMNAFPEPARRAKVLGIWSAIVSTSV
                     GLAPTVGGLLVGTLGWRSIFLVNLPIGIAGLLLTRRVIAAVPGTGAPLGGTGHVLGLLA
                     LGSLSYALIEGPAAGWAAPGVLAAFAVTVLAAAGFVVRERTARTPVLPVTLFADSRFSA
                     ANAVGFLFNLAFYGALFVLGLFLQTGRGADAVTAGLQMLPAVLVIPIGNVLYTRIAPRT
                     GNRAALTVSLALSAAGYLLLFLVLSPTLPYGVIAVVLAVTNIGSGISSPAMTGVLMEAA
                     GREHADIGSATLNANRQVGSLVGIAGMGAILTGAGDAYQGTGYAFALTAVALAAAAVVG
                     WLGVRGRR"
     gene            16932..17945
                     /locus_tag="O1M07_RS29100"
                     /old_locus_tag="O1M07_29095"
     CDS             16932..17945
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087257.1"
                     /locus_tag="O1M07_RS29100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29095"
                     /product="methionine synthase"
                     /protein_id="WP_189854618.1"
                     /transl_table=11
                     /translation="MSENTRHKWAAGAATGIGSMPGGDAREAAKTVTGSLEDFPHLPEL
                     PARGPGADMIGRTLGLLVELYAHVEPSGWRISDRPGRDTRRARSWLGEDLDALEEFTQG
                     YEGPLKVSAVGPWTLAAALEMRNGEAALGDPGACRDLTESLAEGLCGHLAEVRRRVPGA
                     ELVLQLDEPSLTAVLQGRVRTASGYRTHRAVDRAVVEGALRDLVGAADGAPVVVHSCAP
                     EVPFALLRRAGATGISFDAALLTEREDEALGEAVEGGTALFAGVVPGVDGRLSDPAGSV
                     MGVRTLWRRLGLAPGLLAESVVVTPSCGLAGASPAYARAALAHCVRAARSLADNPE"
     gene            17976..20192
                     /gene="ligA"
                     /locus_tag="O1M07_RS29105"
                     /old_locus_tag="O1M07_29100"
     CDS             17976..20192
                     /EC_number="6.5.1.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="ligA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602953.1"
                     /locus_tag="O1M07_RS29105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_29100"
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="WP_189854620.1"
                     /transl_table=11
                     /translation="MAGEQHAAASEVPAAAREKHAQLAEQIEEHRFRYYVKDAPVVSDA
                     EFDKLLRALEALEETHPELRTPDSPTQKVAGSYATEFTEVAHRERMLSLDNAFDDEELS
                     AWAERIATELGGDAKGAGYHFLCELKVDGLAVNLTYEHGRLTRAATRGDGRTGEDITPN
                     VRTIAEIPHRLQGDRVPELVEIRGEVYFPMEKFLELNERLVADGKPPFANPRNAAAGSL
                     RQKDPKVTATRPLHMVVHGLGARDGLEIDRLSEAYGLLKEWGLPTATHNRVVDSLAAVR
                     EFIAHYGDPETRRTAVEHEIDGVVVKLDEIRLQGRLGATSRAPRWAIAWKYPPEEVNTK
                     LVDIRVGVGRTGRVTPYAVVEPVTVAGSEVEFATLHNQDVVKAKGVLIGDTIVIRKAGD
                     VIPEILGPVVDLRDGTEREFVMPAECPECGSALQPAKEGDIDLRCPNARSCPAQIRERL
                     FYLAGRKCLDIENFGYVAATALSQPLEPAEPPLMDEGGLFDLSVEQLLPIKSHVLDPDT
                     GLPKRDPKTGEEKVVTFFANQKGEPKKNTLAMLENIQAAKERPLARILTGLSIRHVGPV
                     AAQALAREFRSIDRIQEASEEELAAVEGVGGTIAASLKQWFAVDWHQEIIERWRAAGVR
                     MEEEQSGETGPRPLEGVTVVVTGTLQSHTRDGAKEALQALGAKVTGSVSKKTGFVVVGD
                     NPGSKYDKAMQLKVPVLDDDGFAVLLEQGPEAARAVAVTPPEEE"
ORIGIN
        1 cggcatcccg cagccggaca agcgggtgga cgaccatccg caccagttct ccggcggtat
       61 gcgccagcgc gccatgatcg ccatggcgct ggtcaacaac cccgagctgc tgatcgcgga
      121 cgagccgacc accgccctgg acgtcaccgt ccaggcacag atcctggacc tgatccgcga
      181 tctgcagaag gagttcggct cggcggtcgt catcatcacc cacgacctgg gcgtggtcgc
      241 cgagctcgcc gacgacctgc tggtgatgta cggcggccgg tgcgtggagc ggggcccctc
      301 ggacgaggtg ttcgccaccc cgcagcaccc ctacacctgg ggcctgctcg gctccatgcc
      361 gcggatcgac cgtgaccaga ccgaccggct catcccggtc aagggctcgc cgcccagcct
      421 gatcaacgtg ccgtccggct gtgccttcaa cccccgttgc ccgtacgcgg acgtccccaa
      481 ggacaacgtc acccgcacgg tgcgccccga actgcagcag gtcgacggcc ggcacttctc
      541 ggcctgccac ctgccgcggg aggagcggga gcgtatctgg accgaagaga ttgcgccgaa
      601 gctgtgaccg agaagactga gaagcctgag gcgaccgcga agcccgagca ggccgagaac
      661 gccgagcagg ccgagcaggt cgagagcgcg gagcagaccg agcagaccgg gggcgccgag
      721 caggccgaga aggccgagaa ggccgagaag gccgagccgg ccgggaacgc cgagagcgcc
      781 gagaaggcgg tgaacacgga gaaggccgag aaggcggaga aggtcgagaa ggcggagaag
      841 gtcgaggagg ccgaggagcc cgcggaggcg gaggaggcag cccggaccgc gaagcccgcg
      901 aagcccgaga agcccgcgcc gacccctgcg gtcgggcgtg ccgagcgctc cgggcccgcc
      961 gccccggatg agccgctgct gcgggtccgc ggcctggtcc ggcacttccc gatcaccaag
     1021 ggcctgctca agcgcaaggt cggggccgtc caggcggtcg acgggatcga cttcgacgtc
     1081 ttccccgggg agacgctggg cgtcgtcggc gagtccggct gcggcaagtc gacgatgggc
     1141 cggctgatca cccggctcga cgaaccgacc ggcggctcgg tcgagttcga gggccaggac
     1201 atcacccacc tgtccccggg ccggctgcgc ccgctgcgcc gcgacatcca gatgatcttc
     1261 caggacccgt acggttcgct gaacccgcgg cacaccatcg gcgggatcgt ctccaccccc
     1321 ttccggctcc agggcgtcga gcccgagggc ggggtcaaga aggaggtgca gcggctgctg
     1381 gagctggtgg gcctgagccc ggagcactac aaccgctatc cgcacgagtt ctccggcggt
     1441 cagcgccagc gcatcggcat cgcgcgggcg ctggccctca agccgaagct ggtggtcgcc
     1501 gacgagccgg tctccgcgct cgacgtctcc atccaggccc aggtcgtcaa cctcatggac
     1561 gacctccagg aggagctggg cctgacctac gtgatcatcg cgcacgacct ctcggtcatc
     1621 cggcacgtct cggaccggat cgcggtgatg tacctcggca agatcgtcga actggccgac
     1681 cgggactcgc tctacgcctc gccccggcac ccgtacacca gggcgctgct ctcggccgtg
     1741 ccggtgcccg accccaagcg gcgcacccag cgcggccgga tcctgctcaa gggcgacgtg
     1801 ccctcgccga tcgacccgcc gtccggctgc cggttccgca cccgctgctg gaaggcgacc
     1861 gaggagtgca ccaccaccga gccgccgctg atccggttgc ggaccgggca ccaggtggcc
     1921 tgccaccacc ccgagggcga gtcggacaac tccggtgcgg cgaccgaaag ttcggacggt
     1981 aaggcatcaa ccgggcagta acgcctgacg acttggcaaa gtcgctggtg aagacggacg
     2041 ggagagtgca gagtcggcgc ggttgttcat cacgcatccg cgtactcgaa gggacggctc
     2101 atggcactct cccgttctgc gcgtcgctcc tcccgttggc tcgccctggc caccgcggtg
     2161 gcctcggccg ccaccatcgc cgcggccccc gcggccacgc cgggcgcccc cggcatcggt
     2221 gacccctact tccccgggtt gggcaacggg ggctaccggc ccctccacta cgacctcggc
     2281 gtcagctacc accccgactc cggccggctg gacggcagga ccacgctgac cgcccgggcc
     2341 acccaggacc tctcctcgtt cgacctggac ctccagaagc tgaccgtcga ccaggtccgg
     2401 gtcgacggcc gccccgcccg cttctccaga accggcgacg aactcgtcat ccggcccggc
     2461 cgcccgctcg cccgcggcga gcgcttcgcg gtcaccgtcg tctaccacgg cgtcccccgg
     2521 ccgctcagcg gcccgatcgt cttcggttcg cagtacggct ggatgaagac caaggacggc
     2581 gtcttcgtgg cctgcgagcc caacgccgcc tcgacgtggt tcccctccag cgaccacccg
     2641 gacgagaagg ccacctacga catccgcatc gacgccccca agggcctgac cggggtctcc
     2701 aacgggcggc tggtcggctc cggcgagcac ggcgaccggg cgtggttcca ctggcgcgag
     2761 agccgcccga tggcgccgta cctggccacc gccaccatcg ggaagttcga cgtgcgcacc
     2821 ggcaccaccc ccggcggcac cccgatctac gtcgccaccg acccgaccct gccgaccggc
     2881 aaggtcgacg tctacggcgt caccgcggcg gccaccgact actggtcgaa ggtcttcggg
     2941 ccgtacccct tcgaggagac cggcgcgatc gtggacgaca tgccgcaggc cggcttctcc
     3001 ctggaggtgc agtccaagcc ggcctactcc gccgtccgca gcgagagcac catcgtccac
     3061 gagctggccc accagtggtt cggcgactcg gtctcggtgc ggcagtggaa ggacatctgg
     3121 ctcaacgagg gcttcgccac ctacgcccag tggctgtggg ccgagcacca gggcacgacc
     3181 accgcccacg acgccttccg caaggcgtac caggggatac ccgccgacga cgccttctgg
     3241 aagatcaagg tctccgaccc gcagcgggac accatgttct ccgatgcggt ctacgagcgc
     3301 ggcgcgatga ccctccaggc gctccgcgaa cgcatcggcg accaggcgtt cttccgcctg
     3361 ctgccggcct ggaccgcccg gcaccgctac ggcaacgcgg acaccgccga cttcgtcgcg
     3421 ctggccgaga aggtctccgg gcagcggctg ggcgacctct tccacacctg gctggacacc
     3481 cagagccgcc ccgcgctgtc gggggagtga ccggctagcc ggcgtcctcg cgcccccggc
     3541 cgctcagctg ctgcggccgg ggcaggtgca gccccagata gagcgcgccc atccggagtg
     3601 cgaacaccaa ccccgccgag accaccgcgg cggggttggc cccggccccg aggcggtcca
     3661 tcagcagata gcagcaggcg ccggccagcg ccgcgatggc gtagacgtcc tcgcgcagca
     3721 gcagcggcgg gaactccccg cacagcacat cgcggatgac ctcgccggcc acgccggtca
     3781 gcaccgccag gatgatcacc gcgagcgggg tggcgcccgc cgagatcgcc gcccgggccc
     3841 ctatcaccgt gaccacggac agcccgatcg cgtccaccac cagcagcgac ttccgcggca
     3901 gcgaccagaa acgcagatag acgatggtgc ccacgccgac gcagatgatc accgtcagca
     3961 gtacccagtc gtgcgtccag tacagcggcc gccggtccag gatcagatcg cgcagcgtgc
     4021 cgccggagat ggacgcggcg aaggcgagga ccagaccgcc gaacgggtcc atgttggcgc
     4081 ggtaggccgc caacacgccg ctcgcggcga aggccgcgac gccgatcagg tagagcacat
     4141 gaagcatgcg gtcatgatga cagccgcgga agcggcggct ccggccgcgt tccccgtccg
     4201 tcgccgtccc gttccttgaa attgacgcta ccagtcggta ataaagccgt gtagcgtgcc
     4261 ggcatggcat cggtgaccgt aggaaacagc gagttcgacc gcgacaccgc ggtcacccgg
     4321 agcgccccgg gcgtctacga cgcgcacctc tccgagggct ggacgatcat caacgccgtc
     4381 aacggcggct acctcctcgc cctcatgggc cgcgccctgg gcgacgccct cccgcacccg
     4441 gacccgctca ccgtcaccgc gcactacctg acggcctcgg tgcccggccc cgccgtcgtc
     4501 cgcaccgagg tgatccgcac cggccgcacc ctgtccaccg gcaccgcctc cctcgtccag
     4561 ttcgccgacg acggtagcga ggtcgagcgg atgcgggtgc tggccaccta cggcgacctc
     4621 gccaccctcc ccgacgacgt ccgcaccacc gccaagcccc cggccatccc gccctacgag
     4681 cactgcctgg gcacggacag tgcccccgac ggccggccgg cgatccccgg cagcaccgcg
     4741 atcgccggac ggctggacct ccggctcgac ccggcgaccg tgggctgggc ggtcggcgcc
     4801 ccgtccggca agggcgagat gcgcggctgg ttcggcctgg ccgacggccg cgaccccgac
     4861 ccgctctccc tcctgctgac cgtcgacgcg ctgccgccca ccgccttcga gctgggcctg
     4921 cgcggctggg tccccaccgt cgagctgacc tgccacgtcc gccaccgccc ggcccccggc
     4981 ccgctgcggg tcgccatcac cacccgcaat ctggccggcg gcttcctgga ggaggacgcc
     5041 gaggtctggg actccgagga ccgcctggtc gcccagtccc gccagctggc ccgcacgatc
     5101 ctggtgcagt agccgcgccg cccggcgaac tcccgcacca tcgggggtgg ttggcccggc
     5161 gcgtgctccg catgccgcag gcgtgggccg tgcggcccgc acggccgacg gggcggggcg
     5221 ccgcggggcc gtcacggccc gatcagggcg tgcgccctgc ggaatgcgcc cccgcgcggg
     5281 gtacgcgccc cggggtggct cgtagaatca gcgcaccatg gtttacctcg accacgccgc
     5341 caccaccccg atgctcccgg aggcggtgca ggcgatgacc gcccagctga ccgtcacggg
     5401 caacgcgtcc tccctgcacg ccgccggccg gcgggcccgg cgtaccgtcg aggaggcgcg
     5461 ggagtcgctc gccgcctccc tgggtgcgcg gcccagcgaa gtcgtcttca cggcgggcgg
     5521 cacggaggcc gacaacctcg cggtcaaggg gctgtactgg tcccgccggg ccgccgaccc
     5581 ggcccgcacc cggatcctcg tcagccccgt cgagcaccac gccgtcctgg acgccgtcga
     5641 gtggctcgcc gagcaggagg gcgccaccgt cgactggctg ccggtcgacc accacggccg
     5701 ggtgcacgcc gaggcgctgc gcgaggcgat cgcccgcaac cccgccgacg tcgcgctggc
     5761 caccgtgatg tgggccaaca acgagatcgg caccgtccag ccgatccgcg aactggccga
     5821 ggtggcaagg gagttcgcga tcccgctgca cgccgacgcg gtccaggcgg tcggccagct
     5881 ggacgtcgac ttcgccgcct ccggactggc cgcgatgacc gtctccggcc acaagatcgg
     5941 tggcccgtac ggcatcggcg cgctgctgct gggccgggag cacgcccccg tgcccgtgct
     6001 gcacggcggc ggccaggaac gccacgtccg ctccggcacc ctcgacaccc ccgcgatcgc
     6061 cgcgttcgcc gcggccggcc ggcacgccgt ggcgcaccgg gaggagttcg cccgcgagat
     6121 cggcgcgctc cgcgacgacc tgatcaaggc ggtgcgggcg gccgcccccg acgccgtcct
     6181 gggaggcgac ccggacccgg ccggccgcct cccggccaac gcccacttca cgttccccgg
     6241 ctgcgagggc gactccctgc tgctcctcct ggacgcccag ggcatcgcct gctccaccgg
     6301 ctccgcctgc accgccggcg tcgcccagcc cagccacgtc ctgctggcca ccgggatgtc
     6361 ccaggacctc gcccgcggca ccctccgctt ctcgctcggc cacacctcca ccgcgaagga
     6421 cgtggcggcc ctcgcggagg tcatcggccc ggtggtggaa cgcgcccggg gcgcggggct
     6481 gagctagggc ctgtccgacg ggtcatggcc gggtccgcga ccctgaccca tcggacaggc
     6541 cctagggccc gtccggccgc gtccgggccg cggggcggcg cagctccgcc cggaccagcg
     6601 tcagatagcg gtcccagtcc cagtgcggcc cggggtcggt gtggtccgtc cccgggacct
     6661 cgatgtgacc gacgatgtgc tcccggtcgg ccgggaagtc gtaccggcgg cagatcccgg
     6721 ccgtcagccg ggccgacgcc gcgtacatgt ccggggtgaa ggactccggc cggtccacga
     6781 atccggcgtg ctcgatcccc acgctgcgct cgttgtagcc gcggttcccg gcgtggaacg
     6841 ccacgtccag ttcgcggacg gtctgcgcga tgtgcccgtc cccgcggacg acgtagtgcg
     6901 ccgacgcctc gtggaagggg tcccggaaga ccttcagcgc ggtggcgaag ctgccctgga
     6961 cgacgtggat caccacgcgg tcgacggtgt ggtcgtcggg gcggttggcc tgccggtagt
     7021 tcgccgggga ggcggcggac cactgcgcac cggcgaagtc gacctcgccc tccttccggg
     7081 ggcggctgtt ccccggcagc tgcccccacc agtacgccag ctcctcgcgg gccgcgaccg
     7141 ccgccgcccc cgcggccacc gcggcaccgc cgccgagcag cagcacccgg cgccgggtga
     7201 gccgcttccc ggcgcgcttc gtgtcgtccg ccgccccgtc cgccgggccc ggggccgtcc
     7261 gctccgcgtc ccgcgcgtcg tccgccgccg tgtcctccac gccccgcacg ccctccacct
     7321 ctcccacgcc ctccacaacg ctttccgggc gccgtccggt tccgtctact ctggagggac
     7381 tatgactgat gccgccgccc cccgccgcct ccgcgtcctc gccgccatgt ccggcggggt
     7441 cgattccgcc gtcgccgcgg cccgcgccgc cgaggcgggc cacgacgtca ccggcgtcca
     7501 cctcgcgctg tccgagaacc ccacgtcgtt ccgcaccggg gcccgcggct gctgcaccat
     7561 cgaggactcg cacgacgccc gccgtgccgc cgacgtcatc ggcatcccct tctacgtctg
     7621 ggacctcgcc gaacgcttcc gcgaggacgt cgtcgaggac ttcatcgccg agtacgaggc
     7681 cggccgcacc ccgaacccgt gcctgcgctg caacgagaag atcaagttcg ccgccctcct
     7741 ggacaaggcg ctcgccctcg gcttcgacgc ggtgtgcacc ggccactacg cccaggtcat
     7801 cctccgcgag gacggctccc gcgagctgca ccgtgccacc gacatggcca aggaccagtc
     7861 ctacgtcctc ggcgtgctcg acgaccgcca gctggcgcac gccatgttcc cgctcggcga
     7921 cacccccacc accaagaccg agatccgcga agaggccgcc cggcgcggcc tgttcgtcgc
     7981 caagaagccc gacagccacg acatctgctt catcgccgac ggcgacaccc agggcttcct
     8041 cgccaagcga ctgggcagcg ccgagggcga catcgtcgac gagtccggca cgaagctcgg
     8101 tacccacgaa ggcgctttcg gcttcacgat cggtcagcgc aaggggctgc gcatcggcac
     8161 cccggccgcg gacggcaagc cgcgctacgt cctggacatc tccccggtga acaacaccgt
     8221 caccgtcggc cccgtcgagt cccttgacgt gaccgcgctc acggccatca agccgcgctg
     8281 gtgcggccgc ccgccggccg acggcccggc cgtctacacc gcccaactgc gcgcccacgg
     8341 cggcgagacc gaggtcaccg ccgaggtggt cggcgaggag ctgcgggtct ccttcaccga
     8401 gcccgtgcgg ggcgtcgccc cgggtcaggc cgtggtcctg tacgacggga cccgcgtggt
     8461 gggttcggcc accatcgcca ccacccgccg ggccgcgccg gtggcctgag ccgggccgac
     8521 ccggccgggc cgtccgcgac acgccggacg cggctgagac atccgacaca ccagaggcgt
     8581 ctgaggctcg tgtggcgtgt gagggtgtcc gaaagtgagc gcaccgcacc gcatcaccac
     8641 gacccggccg ggccgggccc gtccctccaa gggcaggccc ggcccggatt tttccacccc
     8701 gaaaaccggt gggaaggttt ccgattttgt cgcgtcgatg gcgtgaattc ggtactgcgg
     8761 agcgcttaaa ttcacgtcgt tgtgacgaac actctcccga ccccccttgt ccggccagat
     8821 cgtgagctgg tacacctagt ccgaaaaatt gttccgccga actgaatcga acttaagtcg
     8881 ctggtcagcc gggcgggccg gtcgtgaatc cggcccccag ggcaatcgat gcgctattgc
     8941 ctgccgtcgg actcgaccgt gcccgtggat ccgtcccgac gggcgggaac cggtgaggcg
     9001 ccacccatcg cattcgccgt accgcggcgg gcgtgaggtg cgcccaaaag aaggggattg
     9061 atgttggctc acagttcatc tgaatcgccg ccggaatcct tgccggacgc gtggacggtc
     9121 ctcaaaaccc gtaccgccgt ccgcaattac gcgaaagagc cggtcgacga cgcgctgatc
     9181 gagcagctgt tggaggccat gctcgccgcg ccgaccgcct ccaaccggca ggcatggtcg
     9241 ttcatggtgg tgcgcaggcc cgccgcggtc cgccggctgc gcgcgttctc gcccggggtg
     9301 ctgggaaccc ccgccttctt cgtcgtggcc tgcgtcgacc gcagcctgac cgacaacctc
     9361 tccccgaagc tctcgcagaa gatctacgac accagcaagc tctgtgtcgc catggcggtg
     9421 gagaacctgc tgctcgcggc gcacgcggcc ggcctgggtg gatgcccggt gggcagcttc
     9481 aggtccgaca tcgtcaccag catgctcggt atcccggaac acatcgagcc gatgctcgtg
     9541 gtcccgatcg gccgtcccgc gacggccctc gtcccctccc agcgccgcgc caagaatgag
     9601 gtcgtcaact atgaatcctg gggaaaccgt gctgccgccc caactgcgtg aggagatcgc
     9661 actcctcgcc gtttatctgc tcagcagcgg tcgcggactc ctggaggagc cggccgacta
     9721 cggaatttac cgctgtaccg acggggcccg tcgggcgctc caactcctcg acgaacacgg
     9781 cgggagcacg gcacggctga ccgccgtccg cgagcgtctc gacgaggtca tgttcgcgcc
     9841 gatgggcgag gaccgggaca tgggcgcgat tctggacgac ctgtgtcgcc aaatggcaga
     9901 cgctcttccg gaaattgaaa ccccctgacg gctgtccggg gcaaccccaa aaggacttct
     9961 tagcatgctt gcaggcttag ttcccgcgcc ggaccacgga atgcgggaag aaatacttgg
    10021 cgaccgcagc cgaatgatcc ggcaacgcgg tgagcacgcc ctcatcggaa tcagtgcggg
    10081 caacagttat ttcagccaga agaacaccgt catgctgctg caatgggccg ggcagcgctt
    10141 cgagcgcacc gatgtcgtct atgtcgacac ccacatcgac gagatgctga tcgccgacgg
    10201 ccgcagcgcg caggaggccg agcggtcggt caaacgcacg ctcaaggatc tgcgacgcag
    10261 actccggcgc tcgctggaga gcgtgggcga ccacgccgag cggttccgcg tccggtccct
    10321 gtccgagctc caggagaccc ctgagtaccg ggccgtacgc gagcgcaccg accgggcctt
    10381 cgaggaggac gccgaattcg ccaccgcctg cgaggacatg gtgcgggccg tggtgatgaa
    10441 ccggcccggt gacggcgtcg gcatctccgc ggaacacctg cgggccggtc tgaactacgt
    10501 gctggccgag gccccgctct tcgcggactc gcccggcgtc ttctccgtcc cctcctcggt
    10561 gctctgctac cacatcgaca ccccgatcac ggcgttcctg tcccggcgcg agaccggatt
    10621 ccgggcggcc gagggacagg cgtacgtcgt cgtcaggccg caggagctgg ccgacgcggc
    10681 ctagttgggg gcgtccgcgg gcggacctgc ctccccaccc gctcccggtg ccggcaccgg
    10741 gcatgacaaa tgtcacgggg aggacaggac acttgctcat ggtgcggaac ggggcccctc
    10801 ggcgaagctg aaggcgtagg aagacagcac acgtcgcacg ccgggggacc caccatgact
    10861 caagccgcca ccgccaccgc caccacgagc cagggcagga cgctcctgcg gagcctgacg
    10921 ccgctgatcg tggacgccgc gatcccgctc ggctcgtact tcctcctcgc cgagggcttc
    10981 ggcatgagca cggtcgccgc gctggcctgg agcagcgtgg tcccggcgct gcgcacgatc
    11041 tggggcctgg tccgggagcg gacggtcaac ggcctcgcgc tgctgatcct cgtcgtcaac
    11101 gtggtggggc tggcgacgag caccctgacc ggcgatgccc ggctgatgat ggccaaggac
    11161 agcggcgtca gcagcgtcgt cgggatcgcg atcctgctct cggtgcgcgg ccggcgcccg
    11221 ctgatgaccg ccggactccg gccctgggtg accaagggaa gcccggaggg gaacgccgca
    11281 tgggaccggc tgtgggcgcg cagcgcgcgg ttccggcaac tggagcggcg gttctcgacg
    11341 gtctggggga gcgccctgct gatcgagtgc gtggtcaagg tcgtcggtgc gtacgtcctg
    11401 ccggtgcaca ccatggtgtg gctgggcacg gtgctgacgg tggtggcgat cctgctggcc
    11461 atggtggtcg cgggcggcgg cagcgccgag ccgatggagc agatggtcaa ggccgaggtc
    11521 ggggccgccg gcgaggccgc cgaggcgggg aacgccgagc cggcgccggc cgccgcggcc
    11581 tgagaccgcg cggcggggga gttggggaaa tcgcgtacag gattggcgcg tcgagcatcc
    11641 ccgccctcga tagggcggcc cccggcgcat atggtcggcg atgcgacggg acatcggagc
    11701 cccgcgtcga cggttcaacg gcgatccgga cggcacgcgg ctttcgtcgg ccacgaaggg
    11761 aacggaagtc atgtcgactg ttcacactgg ggtcacgcag agcggtctca ccgccgagct
    11821 ggcttccctg cacgccgagc tcgtccgtcg gaatcccggt gaagcggagt tccaccaggc
    11881 ggccctggag gtcctcgaaa cgctttcacc ggtgctcacc gcccggccgg agttcgccga
    11941 cgccaaggtc ctggagcgga tcgtcgagcc ggagcggcag atcatgttcc gcgtgccctg
    12001 gcaggacgac tccggcaaga tccgggtcaa ccgcggcttc cgggtggagt tcaacagcgc
    12061 gctcggcccg tacaagggcg gcctgcggtt ccacgcgtcc gtcaacctcg gcatcgtgaa
    12121 gttcctcggc ttcgagcaga tcttcaagaa cgccctgacc gggctgaaca tcggcggcgg
    12181 caagggcggc agcgacttcg acccgcacgg caggtcggac gccgaggtga tgcgcttctg
    12241 ccagtccttc atgaccgagc tgcaccgtca cctgggcgag cacaccgacg tgccggccgg
    12301 cgacatcggc gtcggcggcc gggagatcgg ctacctcttc ggccagtacc ggcggatcac
    12361 caaccgctgg gaggccggcg tcctgaccgg caagggcctg gcgtggggcg gctccaaggc
    12421 ccgtacggag gccaccggtt acggcaatgt gctgttcacc gaggagatgc tcaagcagcg
    12481 cggcgaggag ctggacggcc agcaggtggt ggtctccggg tccggcaacg tcgccgtcta
    12541 caccgtcgag aaggcccagg cgctcggcgc caacgtcctg accgtctcgg actccggcgg
    12601 ctacgtcgtc gacgagaagg gcatcgacct ggcgctgctc aagcagatca aggaggtcga
    12661 gcgcggccgg gtcgccgact acgcccagcg gcgcggcagt tcggcgaagt acgtcgccgg
    12721 cgggagcgtg tgggacgtcg cctgtgacgt ggcgctgccg tcggccaccc agaacgagct
    12781 cgacgcggac gccgcccgga tcctggtccg caacggcgtc aaggcggtct ccgagggcgc
    12841 caacatgccc accacgccgg aggcggtggc gctgctgaag gaggccggcg tggccttcgg
    12901 tccgggcaag gccgccaacg ccggcggggt ggcgaccagc gcgctggaga tgcggcagaa
    12961 ctccgcccgc gaggcgtggt cgttcgagcg cgcggagggc gaactcgccg ccatcatgcg
    13021 ggggatccac gacacctgcc accagaccgc cgagcgcttc gggcggcccg gtgactacgt
    13081 ggcgggcgcc aacatcgccg gcttcgagcg ggtcgcggac gcgatgctgg accagggcct
    13141 gatctagggc ctgtccgatg ggtcatggcc gggtccgtgg cgtctggtac ggcacctcgc
    13201 cgcgttgccg aaacgcccca atagctccgc tatcgagccg ctccggcgcc ttgcgatgca
    13261 ccgcaccaga cgccacggcc ttgccgcccc tgacccatcg gacaggccct agacgccccg
    13321 ccgggcccgg ccgcggaacc gctccgcggc cgggcccggt gtccttcccc gcgccccgtg
    13381 gggcggtcgc cgcgtgcccg taggctgaac ggcatgaata tctgcgtctt ctgctccgcc
    13441 gccgacctcg acgaccgcta tgtggtgccc gcccgcgaat tcgccgaatc gatcggtcgg
    13501 ggaggacatg ccctggtctg gggcggttcg gacaccgggc tgatgaaggt catggcggac
    13561 ggcgtccagg aggccggcgg gaaactgctc ggggtctccg tggagttcct ggcggacaag
    13621 gcgcgggcca acgcggacga gatggtcgtc accaaggacc tcgccgagcg caaggcgcag
    13681 ctgctggcgc gggccgacgc catcgtcgtc atggtgggcg gcaccggcac gctggacgag
    13741 gcgaccgaga tcctggagct gcgcaagcac gggatgcaca gcaagccggt ggtgctgctg
    13801 aacaccgctg gtttctacga cgggctcaag gcccagttcg agcggatgga ggcggagggc
    13861 ttcctgcccg ttcccctctc cgagctggtg ttcttcgccg aggacggcgc ggccgcgctg
    13921 gcccacctgg aagcgctggc gggcgccgcg ggctgacccg cccatggggg cacgccgtag
    13981 gatcgccccc atgggtacgc acttgatcac gggcgccgga tcgggcatcg gagcggcggt
    14041 cgcacggcgg ctcgccgagc gcggtgagga gctgtggctg ctggcgcgcg acgtcggccg
    14101 ggccaaggag ttggcggagc ggttccccgg ggcgcacacc ctcgtcggtg acctcgccac
    14161 ccccgagaag ctcgactggg cgctcgggca ccaacggctg ccggagcggc tcgactcgat
    14221 ccagcacatc gcgggcgtca tcgagctggg tgcggtcggc gacctgccgg ccaaggcgtg
    14281 gcagcggcag ctggcggtca acctcgtcgc gcccgccgag atcacccggc tgttgctgcc
    14341 gctggtccgg atcgccaagg gcgacgtggt cttcgtcaac tccggtgccg ggctcaccgc
    14401 gaaccccaac tggggcgggt acgccgcgag caagcacggc ctgaaggcgc tggccgacgc
    14461 gctgcgtgcg gaggagcacg acaacggcgt ccgggtcacc tcgatctacc cggggcgcac
    14521 cgccacgccc atgcaggaga gcacccaccg tcaggagggc aaggcgtacg acgcgtcccg
    14581 gtggatcgac ccggagtcgg tggccacggc catcctcacc gcgatcgacc tgccgcggga
    14641 cgcggagatc aaggacctgg tggtccggcc gggccgctga ccggacccgg ccccggggct
    14701 cccggggccg cccggcggtc cgcccgccct cgcccccgtg caccgcgcgg gggcgacgta
    14761 ggcttcaggg gtgaccacgt caagggcgac caccgaagcg aagaccaccg ccgcggccgg
    14821 gtgcgggttc cgggagatca gggggctggt caccgagctg agccgccgcc tggacgccca
    14881 ccagcgcagc cggatcgcgg agctggacct gacgccgacg caggcgaagg cgctggagga
    14941 gctgggcgag cccaagaccg cgcgggagtt ggccgcggtg ctgtgctgcg agccgccgaa
    15001 cgtcacctac gtcatctcca agctggagaa gcaggggatg gtggtccgcc gcccgcaccc
    15061 cgcggacggg cgcgccaagc agctggtgct gaccgaggcc ggtcgggagc tgcggctgga
    15121 cctgctgcgg cggatgggca cggagtcccc gctggaccac ctatcccacg aggagcgcag
    15181 cgggctccgc gacgaactcc tcagagcgct gggccgggtc gcgggctagg gcctgtccga
    15241 tgggtcaggg tcggcaaggc cgtaccagac gccgcggatc cggccatgac ccatcggaca
    15301 ggccctagcg cccgaccgcc gtcgcgccga aggcccccgg gcatggtccc gggggccttc
    15361 ggcgtttctc ggtatcgctt cgataaagtt atagctgtaa ccatcgcgca cgacggatag
    15421 atacagctat aactaaatcc atgatcactg agaacgcggc gccgcgcgcg acggcgagca
    15481 cccccacccg tcccgcaccc gccggcggag ccgcccaact cgtcgtcctg gccctggggt
    15541 tcgtgatggc gagcctggac accggcatca tgaacgtcgc cgcgcacgac ctccgggccc
    15601 ggctcgggct gaccatgtcc ggcctcacct gggtcgtcga cggctacgtc ctcgccttcg
    15661 ccgcgctgct gctgctcgcc ggctcgctcg ccaagcggtt cggcgcccgg cggacctacc
    15721 tcgtcgggct ggccgtcttc accgccgcgt ccctgctggg cgccgcggca ccgggcggcg
    15781 gcgccctggt ggcggcccgc ttcgcccaag gggcgggcgc cgcgctcttc atgcccagct
    15841 cgctgtcgct gctgatgaac gccttcccgg agccggcccg ccgggcgaag gtgctcggca
    15901 tctggtccgc gatcgtctcc acctccgtcg gcctggcacc gaccgtcggc ggcctgctcg
    15961 tcggcaccct cggctggcgc agcatcttcc tggtcaacct ccccatcggg atcgccggac
    16021 tgctgctcac ccgccgggtg atcgccgcgg tcccgggcac cggcgccccg ctcggcggca
    16081 ccggccacgt cctcggcctg ctcgccctcg gctcgctcag ctacgccctc atcgaggggc
    16141 ccgccgccgg ctgggccgcc cccggcgtcc tggccgcgtt cgcggtgacc gtgctcgccg
    16201 ccgccgggtt cgtggtccgg gaacgcaccg cccgcacccc ggtcctgccc gtcaccctct
    16261 tcgccgacag ccgcttctcc gccgccaacg cggtcggctt cctcttcaac ctcgccttct
    16321 acggggcgct gttcgtgctc gggctcttcc tccagacggg ccgcggcgcc gacgcggtga
    16381 ccgcgggtct gcagatgctc ccggccgtcc tcgtcatccc gatcggcaac gtgctctaca
    16441 cgcggatcgc gccgcgcacc ggcaaccggg cggcgctcac cgtctccctg gccctctccg
    16501 ccgccggcta cctcctgctc ttcctggtcc tctcgccgac cctgccgtac ggggtgatcg
    16561 cggtggtgct ggccgtcacc aacatcggca gcgggatcag ctccccggcg atgaccggcg
    16621 tcctgatgga ggccgcgggc cgcgagcacg ccgacatcgg cagcgcgacc ctcaacgcca
    16681 accgccaggt cggctcgctg gtcggcatcg ccggcatggg cgcgatcctg accggcgcgg
    16741 gcgacgccta ccagggcacc ggatacgcct tcgcgctgac cgcggtggcc ctggccgccg
    16801 cggcggtggt cggctggctg ggcgtccgcg gccggcgctg acccgggcgc ggcgttcgcg
    16861 ccgggcgtac ggaggtgggc cgggcggggc tggggcggcc cgcccggccc accgccgcat
    16921 acccttccgg ggtgagcgag aacaccaggc acaagtgggc cgcgggcgcg gcgaccggca
    16981 tcgggtcgat gccgggcggc gacgcgcgcg aagcggcgaa gaccgtcacc ggatcgctgg
    17041 aggacttccc ccatctgccc gagctcccgg cccgggggcc cggcgccgac atgatcggcc
    17101 gcaccctggg cctgctcgtc gagctctacg cccatgtgga gcccagcggc tggcggatca
    17161 gcgaccggcc cggccgcgac acccgccggg cccgctcctg gctcggcgag gacctcgacg
    17221 ccctggagga gttcacccag ggatacgagg gaccgctgaa ggtctccgcg gtcggcccgt
    17281 ggaccctggc cgccgcactg gagatgcgca acggcgaggc ggcgctcggc gaccccgggg
    17341 cctgccggga cctcaccgag tcgctcgccg agggactgtg cggccatctc gccgaggtcc
    17401 gacggcgggt gccgggcgcc gaactcgtcc tccagctcga cgagccgtcg ctgaccgcgg
    17461 tgctccaggg gcgggtgcgg accgcgagcg gctaccgcac ccaccgggcc gtggaccgcg
    17521 cggtcgtcga gggcgcgctg cgcgacctgg tcggggcggc ggacggcgca ccggtcgtgg
    17581 tccattcctg cgcgcccgag gtgccgttcg cactgctgcg acgggccggc gcgaccggca
    17641 tctcgttcga tgccgcgctg ctcaccgagc gtgaggacga ggcgctcggc gaggcggtgg
    17701 agggcggtac cgcgctgttc gcgggcgtgg tgccgggcgt ggacggtcga ttgtcagacc
    17761 ctgccggtag cgtcatgggt gtccggacgc tgtggcgcag gctggggctg gcaccgggac
    17821 ttctcgcgga gtccgtggtg gtcaccccgt cgtgcggtct ggcgggcgcc tcgcccgcct
    17881 acgcccgcgc ggcgctcgcc cactgcgtcc gggcggcgag gtcactcgca gacaaccctg
    17941 agtgaccgcc ctcaaggaca cgggaggaca agacggtggc tggcgaacag cacgcggcgg
    18001 catccgaggt gcccgccgcg gcacgggaga agcacgcgca gctcgctgag cagatcgagg
    18061 agcaccgctt ccggtactac gtgaaggacg ccccggtcgt cagcgacgcg gagttcgaca
    18121 agctgctgcg cgccctggag gccctggagg agacccatcc cgagctgcgc accccggact
    18181 ccccgaccca gaaggtcgcc ggttcgtacg ccacggagtt caccgaggtc gcgcaccgcg
    18241 agcggatgct ctcgttggac aacgccttcg acgacgagga gctgtcggcc tgggccgagc
    18301 ggatcgccac cgaactgggc ggcgacgcca agggcgccgg ctaccacttc ctgtgcgagc
    18361 tgaaggtcga cggcctcgcg gtcaacctca cctacgagca cggccgcctc acccgcgccg
    18421 ccacccgggg cgacggccgc accggcgagg acatcacgcc caacgtccgc accatcgccg
    18481 agatcccgca ccgcctccag ggcgaccggg tccccgagct ggtcgagatc cgcggggagg
    18541 tctacttccc gatggagaag ttcctggagc tcaacgagcg cctggtggcc gacggcaagc
    18601 cgccgttcgc caacccccgc aacgccgcgg cgggttcgct gcgccagaag gaccccaagg
    18661 tcaccgccac ccgcccgctg cacatggtgg tgcacggcct cggcgcccgc gacggcctgg
    18721 agatcgaccg cctctccgag gcgtacggcc tgctcaagga gtggggcctg cccaccgcca
    18781 cgcacaaccg cgtggtggac tccctcgccg cggtacggga gttcatcgcc cactacggcg
    18841 accccgagac ccgccgcacg gccgtcgagc acgagatcga cggcgtcgtg gtcaagctcg
    18901 acgagatccg gctccagggc cggctgggcg ccacctcgcg ggcgccgcgc tgggcgatcg
    18961 cctggaagta cccgccggag gaggtcaaca ccaagctggt ggacatccgc gtcggcgtcg
    19021 gccgcaccgg acgggtcacg ccgtacgcgg tcgtcgagcc ggtcaccgtc gccggttccg
    19081 aggtggagtt cgccaccctg cacaaccagg acgtggtcaa ggcgaagggc gtcctgatcg
    19141 gcgacaccat cgtcatccgc aaggcgggcg acgtcattcc ggagatcctg ggcccggtcg
    19201 tcgacctgcg ggacggcacc gagcgggagt tcgtgatgcc cgccgagtgc cccgagtgcg
    19261 gctcggcgct ccagcccgcc aaggaaggcg acatcgacct gcggtgcccc aacgcccggt
    19321 cctgccccgc ccagatccgc gagcggctgt tctacctcgc cggccgcaag tgcctggaca
    19381 tcgagaactt cggctatgtc gccgccaccg ccctcagcca gccgctggag cccgccgagc
    19441 cgccgctgat ggacgagggc ggtctgttcg acctctccgt cgagcagctg ctgcccatca
    19501 agtcccatgt cctcgatccg gacaccggcc tgcccaagcg cgacccgaag accggcgagg
    19561 agaaggtcgt caccttcttc gccaaccaga agggcgagcc gaagaagaac accctggcca
    19621 tgttggagaa catccaggcg gccaaggagc gcccgctggc ccggatcctc accgggctgt
    19681 cgatccgtca cgtgggcccg gtggcggcgc aggcgctggc ccgggagttc cgctcgatcg
    19741 accggatcca ggaggcgagc gaggaggaac tggcggccgt ggagggcgtc ggcggcacca
    19801 tcgccgcctc gctcaagcag tggttcgccg tggactggca ccaggagatc atcgagcgct
    19861 ggcgggccgc gggcgtccgt atggaggagg agcagtcggg tgaaacgggc ccgcgtcccc
    19921 tggaaggcgt caccgtcgtg gtaacgggca cacttcagtc acacaccaga gatggcgcga
    19981 aagaagcgct acaggctctt ggtgcgaagg tgaccggatc cgtttccaag aagaccggat
    20041 tcgtagtggt gggcgacaac cccggttcga agtacgacaa agccatgcag ttgaaggtcc
    20101 ccgtgttgga cgatgacggc ttcgctgtgc tgctggagca gggtcccgag gcggcacgag
    20161 cggtagctgt cactccgcct gaggaggagt gaggtgtcac cccatcggcg cataccagat
    20221 tgatctggga ggccgggtcg cattcgggca accgctgcgg atcgctgccc gcagtggcct
    20281 tccgcgtcct actgttgacg tgtgcgcctg ccgtggcgcg ggcacagccg gctgtgagag
    20341 ggatcggaat gaaaccgacc gacagcgccg ctccggcgtc gcggctccgc cggcttgtgg
    20401 tgcccgcgtt gcccgcggcc ctcgtcatgg cggcgggcct ggtgctcgcc gccggtgtgc
    20461 tccactcgct cggtgacggc gagccgttgt tccccgccgg agccatcggc tggtcgctgg
    20521 cggtcctgac cggcgtcatc gtcggccatc tggtcgccct cggccgggac cggtggtggg
    20581 gcggcaccgg ttccggggcg gccctcgccc tcgccgtgct cctgctctac ggctgggtgc
    20641 cggccatcct ggtcagcctc tccgtcgtgg tcctggtcgg cgcc
//
