LOCUS       NZ_JAPTYM010000001     24457 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3848673
            Orig. end                         :: 3873130
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24457
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="20"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24457
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24457
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14457](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14457)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    84..98
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.12"
                     /tool="antismash"
     gene            complement(279..1985)
                     /locus_tag="O1M07_RS17100"
                     /old_locus_tag="O1M07_17095"
     CDS             complement(279..1985)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893204.1"
                     /locus_tag="O1M07_RS17100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17095"
                     /product="AIPR family protein"
                     /protein_id="WP_229921393.1"
                     /transl_table=11
                     /translation="MDRVLEDQHSRLAPDQKLDDFFNYFTASTALQDLDLDIDELRDGI
                     VDGSHDCGIDGIWVLVDDRYVSADIARHANVRAGKIELVILQAKTASGYQETAFEKLHY
                     HLPLLLDMNRNIADLAQSTNAKLLDRTGRFLNVLEALASSFPKVFVRVIYASRAAEGPH
                     PNVRAKGNRLAAELAKIASETKCSVEYLGAAELRALSARGAVVVSELVFTETPMSTSLG
                     EGYVCLARLDEYYNFITSPNEALRLELFESNVRDYAGRTSVNTEIGETLKNNHREDFWW
                     FNNGVTIVAEEVRIAGKKIVMKDPQIVNGLQTSHEIYKYFQGSAQNHRDRCILVRIMVP
                     PKSGRARDAIIRATNSQTQLPPGALRATEQIQKDIEESLQRDSYYYERRANYYKNLGFR
                     LEQVVSMSRLAREYTAFVVGEPHVALKLPESLLLDDDHYYKVFSVENDLDLYRLVLDVH
                     IRISEFLNSYREFKTLLGDTSENWRYHLAYMARFTLTRLRRPTQRDFLNVKIEHLSDEL
                     LEQMTGLLDRTYRASLRGNRTKGIDRVARSVDFTHQLRQETISMRRFKIDH"
     misc_feature    complement(1629..1631)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1938..1951)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.2"
                     /tool="antismash"
     misc_feature    2112..2125
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.61"
                     /tool="antismash"
     misc_feature    complement(2112..2125)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.31"
                     /tool="antismash"
     misc_feature    2287..2302
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.73"
                     /tool="antismash"
     misc_feature    2684..2699
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.91"
                     /tool="antismash"
     misc_feature    complement(3607..3621)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.43"
                     /tool="antismash"
     gene            3893..5092
                     /locus_tag="O1M07_RS47285"
                     /old_locus_tag="O1M07_17100"
     CDS             3893..5092
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="O1M07_RS47285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17100"
                     /product="sensor histidine kinase"
                     /protein_id="WP_189855598.1"
                     /transl_table=11
                     /translation="MGGRRAAFAVDGVVVAAATAELLTLYDALDGLSALVCPPSLFALV
                     LRRRFPVAVLFATLPSMATGHLWLAPMIAMFTVASRTARRAVVGVATAALFAATMWSGY
                     DLDGGAVDWSHHLFVVEVALMFSVGPAGLGLLFRTRSELRARLADLIASQAHGRRLEAE
                     RAVAEERTRMAREMHDSVSYHLGIIAAQSGALWATAPDDTVRRDAETIRRHSADAMAEL
                     REIVGVLRHGPSRADGTDARLRNVPTLVAEARLDATLDCGALEAHTLAPSVERAAYRTV
                     QEALTNVRKHAPGAPVAASVRPSARGDALVVEVRNQPAPRTPPSVAPVLDVPASGYGLA
                     GLRERVTLVGGAFRAEATADGGFVVRAELPLGPAAPPASGPAPGDQPATAAQGESGSRS
                     "
     gene            complement(5047..5811)
                     /locus_tag="O1M07_RS17110"
                     /old_locus_tag="O1M07_17105"
     CDS             complement(5047..5811)
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980774.1"
                     /locus_tag="O1M07_RS17110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17105"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_189855603.1"
                     /transl_table=11
                     /translation="MALGNALYDRKLASVYDRMYPIDHDTAQAVEFVAGRTPPDGSILE
                     LGVGTGRIAVPLAERGFRVHGIDGSEAMLDELHKQHPRTAVTTQFGDFTEEGTGGVFDT
                     VTLLLNTFFVAITKEQQLGTLRRVREQLAPEGRFVLEAFDPAPYHHLEKPDFSMRHLDE
                     HAVMLDTLAVDRSQQLMLSTHTIIDGGAPATREHVLRYAFPFEIDLLAELSGLRLVERT
                     EDWCGTPYTSASLRHVSVYERDPDSPWAAVAG"
     gene            complement(5880..6557)
                     /locus_tag="O1M07_RS17115"
                     /old_locus_tag="O1M07_17110"
     CDS             complement(5880..6557)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718115.1"
                     /locus_tag="O1M07_RS17115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17110"
                     /product="response regulator transcription factor"
                     /protein_id="WP_189855604.1"
                     /transl_table=11
                     /translation="MIRVMIVDDEILLRSCMQRILESEADIEVPVACDGREVREAVAAH
                     RPDVVLLDLRMPEVDGLTALEWIRAHQDPPAVAVLTTFLRDEDVAAALRSGAAGFLLKD
                     ATPQELADAVRVLASGGTVLSPAAARIVVDGYLGAGPRHGERDPRLDTLTERELQVLEL
                     LGEGLTNADIGRRLLLSASTAKEHVSSILTKLGLANRVQAAVAAHRAATEGHLRPSALA
                     ETR"
     misc_feature    6653..6668
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.68"
                     /tool="antismash"
     misc_feature    6655..6669
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.77"
                     /tool="antismash"
     misc_feature    complement(6657..6668)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.87"
                     /tool="antismash"
     gene            complement(6690..6908)
                     /locus_tag="O1M07_RS17120"
                     /old_locus_tag="O1M07_17115"
     CDS             complement(6690..6908)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS17120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_17115"
                     /product="hypothetical protein"
                     /protein_id="WP_189855606.1"
                     /transl_table=11
                     /translation="MSSSGVVLDGPGPRALALSGPAAAATGGGRFGTALDCTVTAEGGS
                     AKKIELLVSTWDAKLVELITERLSEPV"
     misc_feature    7089..7107
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.54"
                     /tool="antismash"
     gene            complement(7103..8137)
                     /locus_tag="O1M07_RS17125"
                     /old_locus_tag="O1M07_17120"
     CDS             complement(7103..8137)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324900.1"
                     /locus_tag="O1M07_RS17125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17120"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_229921394.1"
                     /transl_table=11
                     /translation="MTRTPPLSLMYPLMAYDLDHLTAFGEVVRELSLERLYMGQSVLVD
                     THHAFAHLAGRGIRVPVGTSVALTALRHPLDAAIQARSLALLTGADVVAGYSTGDPAFV
                     TALRGAPYASPRTAVAEYLTVVRRLLDGELVDFQGRYVRVDEGLPQVPHPPVSLGVGVL
                     RPRMAYTAGQVADVAITLLTPATHLRDQIVPALARGAASRDRAVPGVTSIVPCAVRKPG
                     RDPRRLAFAAHELHLGGEHYAAMLRSAGLGVDAADPWAGAGVLVDSGVFAYGTPDELAD
                     RLTGYGEAGATEIALSCAGVLLTEGLDAALADVRAIVGAMQDRAVRRADEGPGFCTSSH
                     PELS"
     gene            complement(8161..10008)
                     /locus_tag="O1M07_RS17130"
                     /old_locus_tag="O1M07_17125"
     CDS             complement(8161..10008)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741466.1"
                     /locus_tag="O1M07_RS17130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17125"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189855608.1"
                     /transl_table=11
                     /translation="MTDQEASGQTVPEEHRRLSRDLRYWWLVLRTFWGLSPLRVSALAV
                     ATALTAAVPATGIWLTARAVQAVVDALTRVPDAMDRLTFAAAGLVAVSVAEHILTSLAQ
                     YLNSLLQLEFTAKIGERVMVKGTRMDLSAYEDPEAYDRLQRALRESGSGTAFEVFEEMM
                     RTLTALASLVMVSWVLFSWNVWIALAILLAPLPALAAHVVFSKQGYAIEYHRAQDRRRA
                     FYYQDLTTTDSSYKEVKLYQLGPHLVGRYRSLVQEFFRVDRALARRRHGWSATLGLVSV
                     GCSAGALVFALRSTADNGRIGELAGYLQALGAVHAAATGLLLGVATLYQNTLFTGNLFD
                     YLTLPDGRITGGTRPFPRRLTHGIEFQDVTFRYPGTTTTALDRFSCFIPADTCCAIVGA
                     NGAGKSTIVKLLSRLYEPTSGRILVDGVPLEEYDTDDLQRNIGVVFQDFIRYEMPVRHN
                     IGFGRLEHLDDDARLRAAAGSSGAAEFIDRLADTYDTTLGRHFEGGHQLSGGQWQKIAL
                     ARAFLRDAPIAILDEPTAAIDAEAEADIFGRLRTICSRATSLVISHRFSTVRIADKILV
                     VEGGSLIEEGTHEELLARGGTYAHLFRLQADAYLPGASA"
     gene            complement(10001..13207)
                     /locus_tag="O1M07_RS17135"
                     /old_locus_tag="O1M07_17130"
     CDS             complement(10001..13207)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327746.1"
                     /locus_tag="O1M07_RS17135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17130"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_229921395.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.3e-156,
                     bitscore: 521.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.3e-14,
                     bitscore: 52.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.9e-29, bitscore:
                     101.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAIDKDLTRPMPRYEALDFPLLRAPALPVEVWRETLADRDLTRT
                     RARLRAMADNPRVRHGLVAAGSGLLDGLAKVEAAQGRASGKETRRVHSRALRYLTRMST
                     RPTPFGAFSGVALGSFGETTTARLGATPFVSARVRADMGWLLALVKDLEGAPEVLERLS
                     VSMNAMAHRVGDRLVLPSSDVHGNADRRSVRVRHTSPLSHVRRLAPAAAPVPYAEVVAE
                     LTDRFPAVGHERISAFVAELVGLGLLVTDLRPPVTDPCPEAYVLARLTAAGVEHPAVAG
                     LREVVDMTRTAVHDDTGALDRLRLAQRTLVPEYRHQPFQVDSALGLADTAINRQVADEV
                     AEAVGCLARLGRAAPGGYDHLAPYHEAFMERYGSDALVPVLELLSAERGLDAPNSYLDP
                     PRAMVMHQTGGEGDPRTARALVALASQAWRSGADEVELSDEVLRRLVPADEGDARRGCP
                     GVDAYVQIAASSARAIDDGDWRAVLNSDGLGEGGRTFGRFFHLLGPSAAERLRSYARAR
                     EALEPDVVVAELAYLPGNGRGANVAIRPAVHGYEIPVNVAPSAAPDRIIDLSDIHVGAT
                     DDGLRLYSARLGRELVVVQNHMLSPLGAPNVCRFLLEVSRARYAMPTGFTWGPVEGAPY
                     LPRVVRGRVVVRAAEWNLYPTGARAPLDTAPVPVPRTAAELTEWRRTWGVPRHVYLADD
                     DNRLLLDLDHPACADELLTDLRAADERVTLQEALPDPDRTWLRDSAGRGHLAEVVIPLL
                     AAPDGTEAAPPPDTAPAREAAAEGIRRKARPAAHPSHLPGSEWSYLKLYAARDLHDEIA
                     AVELAGLVQEIRDAGADVDRWFYIRYADPDAHLRIRTRTPAGGTSALEPLLDWGRSLVR
                     RGIAERLEVATYHPEVSRYGGPAVYDHIEEFFAANSAVSAQLLGLLWDKEPGLTAEAVT
                     LAAVDALYAQWGLDVRERLAAMPRPAEDREARERYKKDRDYLCELLAPWDRRPHLGGRA
                     HHERLAPVLAGQVDAVRRASRAVADAEAAGTLWGTRDAVLASLAHMQVNRLLPMDRPAE
                     DRCYLIWGHVLNCLRGRPRD"
     aSDomain        complement(12443..12718)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_O1M07_RS17135_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.30E-17"
                     /identifier="RREFam001.1"
                     /label="O1M07_RS17135"
                     /locus_tag="O1M07_RS17135"
                     /protein_end="255"
                     /protein_start="163"
                     /score="52.9"
                     /tool="antismash"
                     /translation="VSMNAMAHRVGDRLVLPSSDVHGNADRRSVRVRHTSPLSHVRRLA
                     PAAAPVPYAEVVAELTDRFPAVGHERISAFVAELVGLGLLVTDLRPP"
     gene            complement(13204..14457)
                     /locus_tag="O1M07_RS17140"
                     /old_locus_tag="O1M07_17135"
     CDS             complement(13204..14457)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="O1M07_RS17140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17135"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_189855610.1"
                     /sec_met_domain="LANC_like (E-value: 5e-38, bitscore:
                     129.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPSPLLPPELAARANAVASVIRERLDSPAGADAHAARAAGQSEL
                     SFWNGASLSEGHAGLALLHLHAARTAERGAEGEWSRDLAFSFVRAAFAATQEDALTHPG
                     LFDGTAGLAFVLREVAADEPRFLPSLAALDEQLSRQALAMELPRRPGAVAAHHYDLVYG
                     CAGVLAHLCRVRPTTPLVEQALQRCLRYLLWVGADQRWAVEGRLDTGMSHGAAGIAAAL
                     ATAWRHGHRLPGQRLVLDRLVAWLLEVGSRGGRQLQWPRSVPVDPRLDDGDEAVPAWCH
                     GTGGVAVGLLTVADATGDRALEARAFAALDGLLDRVAAGDVPRSPTVCHGLAGCVALAH
                     EFAARGSEGAARGLARLVTELLDAAEPERALVYRDHETTGHVVDNPGLLTGAAGVALTL
                     RATATGRRPSWWRVLFLR"
     gene            complement(14547..14729)
                     /locus_tag="O1M07_RS17145"
                     /old_locus_tag="O1M07_17140"
     CDS             complement(14547..14729)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS17145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_17140"
                     /product="hypothetical protein"
                     /protein_id="WP_067351401.1"
                     /transl_table=11
                     /translation="MDEFNLDARVIVSADPAQTSLSPVASVASRVASKWAVKQTIRQTI
                     KMTAACAAVRTNGKC"
     gene            complement(14746..15411)
                     /locus_tag="O1M07_RS17150"
                     /old_locus_tag="O1M07_17145"
     CDS             complement(14746..15411)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS17150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_17145"
                     /product="hypothetical protein"
                     /protein_id="WP_229921396.1"
                     /transl_table=11
                     /translation="MWQPDDILMTQKIAPLVNRYVFTLPESGEVIAFAEQKRFALQEQL
                     TLWTDEDRSRELGGFKAREVIDLGATYDVTGTGGDLIGSFRKDFKASFLRSTWHLTQGK
                     ESAAVGKERRVGVALARRAWDVVDLVVPLVTLPPYPGSGVGPDTRALHGSWAGRPAGAL
                     TVGHRSAGRTVPPHGGGRKGRSAGSRASSASLNSFSDRLGNSCGTPSSFPRWAVGSME"
     misc_feature    complement(14827..14829)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15623..17002)
                     /locus_tag="O1M07_RS17155"
                     /old_locus_tag="O1M07_17150"
     CDS             complement(15623..17002)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567917.1"
                     /locus_tag="O1M07_RS17155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17150"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_189855612.1"
                     /transl_table=11
                     /translation="MTRETTPHHTDKARETRGAYGARERCEPTPTPAARARTVLISGAS
                     IAGPALAHWLARYGYRPTVVEWAPALRGGGFAVDFRGAAHLAVLRKMGVLEEIRQRRTG
                     GASMTFIDARGNHVAALPPEFAGGDVEILRSELSRILYDHSRPTPTLHDDTATPAAGAG
                     TAYLFGDSLTSLTETADGVHVTFEHAPPRTFDLVIGADGLHSTVRRLAFGPEEDFVSHL
                     GYYVAGWDLPHGAAPDLAAHAVGYNEPGRLVTVGRVPRRAADPSYAGEAFCVFASERLG
                     HDRRDPQAQRTALVRAYEGAGWRTAELVGTVRDADDLYFDAISRVDAPTWSRGRIALLG
                     DAAYGATVGGMGTGSAIVGAYVLAGELALAAGDHRRAFARYEQKLRPYVSRCQEGGRGT
                     GAFLAPLTQEAIAARNSALNDPAALTAMLQEGHDISADISLDDYPSLVHHDTGSVRNAT
                     P"
     gene            17101..17850
                     /locus_tag="O1M07_RS17160"
                     /old_locus_tag="O1M07_17155"
     CDS             17101..17850
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088365.1"
                     /locus_tag="O1M07_RS17160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17155"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_189855614.1"
                     /transl_table=11
                     /translation="MAGDEKSSAFGDQAGSVELLWGGRERPSRGPKPALSLERITRTAI
                     NLADTGGLGAVSMQRVAAELDFTKMSLYRYVPGKAELVALMIDTAMGEPPEPAGAAAGD
                     WRGALRDWAQRLAAVFAQHPWLLSALVGPRVMGPNELGWTERALAALAGTGLTGGEQLD
                     AVLVVSGHVRSIAQVSASMGVGGAPAKEPEAALSAALNELLVGRSERFPALSAALAGAA
                     RGESRDQAWEFGLERILDGLEAYAGRV"
     gene            complement(17896..19071)
                     /locus_tag="O1M07_RS17165"
                     /old_locus_tag="O1M07_17160"
     CDS             complement(17896..19071)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000902 - cell morphogenesis [Evidence
                     IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715790.1"
                     /locus_tag="O1M07_RS17165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17160"
                     /product="rod shape-determining protein"
                     /protein_id="WP_189855616.1"
                     /transl_table=11
                     /translation="MASSTSSGTYDIGIDLGTANTLVYARGKGVVLNEPSVVAVNAAGD
                     VVAVGSEAKRTIGRTPSGITAMRPLREGVIADFDAAEQMLRALMKKALPSRRFSRPRVV
                     ICVPSGITGVERRAVIDSARGAGAREVHLIEEPMAAAIGAGLPVAEPVGCMVVDIGGGT
                     TEVAVVSMGGLVTAQSVRVAGDAMDAAISTYIKKEHGLAIGERTAEDIKIAIGSAVWTP
                     DDDRPLPTRLAVGAASDSVSDPASDAEADAESPADRAARPSPHSYTVRGRDHLSGLPRL
                     QEITAEEIRAALAEPVEAIVRAVHNTLDDCPPELSGDIIERGIALTGGGALLRGLDRRL
                     REEMGVPVVVADAPLDCVVNGTAKCVDEFATLHGLLTGAKEGPRKSVRLGM"
     gene            complement(19235..21301)
                     /locus_tag="O1M07_RS17170"
                     /old_locus_tag="O1M07_17165"
     CDS             complement(19235..21301)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541961.1"
                     /locus_tag="O1M07_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17165"
                     /product="FUSC family protein"
                     /protein_id="WP_189855618.1"
                     /transl_table=11
                     /translation="MTWSRALKEATRSGLTIERAKLTPLIAIRGTVGVAVVLGLCLWRG
                     NPALAVSSAFGAFSAGIVTFQRSMRPRPVLALAVAGALAISTFLGYLAAAHVVWFVLLL
                     TGWTLLAGMAWAIGPVSGLVGTQTVAIMLITVTLPTSVLGALEHAALIACGGLVQAALI
                     VLFPVRPWGIQRDTLADALAAEADYARRLRHDPVAPFDPAPLMDARAAATVTPRQARRR
                     PVQLHGPRGLAERVRPVLASLADPVVGAPLEGPERDRARELLGAAATVLDAVAHAVRHA
                     SPVRLPPEAMAALEVPASGPMLRGPARRTAYRLISLLADAVELTDEPVEATRPTTEAER
                     GHLLRPSVPRLVPVALRALRREARWSSHVLRHALRVAAVAVAGYLLGAALHFGHGYWAP
                     LASVMVMRPDFAQTYSRGVARFAGTVVGVTLAGALMALAHPGAYVSAALALLCVFLMYL
                     LMRTGFSVTSACIAAYVVFLLGIVGAGWEQTVQERLVLTLIGGVLAMLSYALFPAWETP
                     RLRDRLADWLATNGRYALAVVDGYARPAERRPRQVREALLDARAARAAWEATEARAEKE
                     PVRHRGLPLGGAHAASAALATMGRVTMILEAHPPDRDARPSPGAAAFAAALRPALDRAV
                     RAVRDGEAMDWGEPHAAWERWSAEDEHEGVAVRATELLLDALDDLAEALPPDP"
     gene            21715..22737
                     /locus_tag="O1M07_RS17175"
                     /old_locus_tag="O1M07_17170"
     CDS             21715..22737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571347.1"
                     /locus_tag="O1M07_RS17175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17170"
                     /product="esterase family protein"
                     /protein_id="WP_189855620.1"
                     /transl_table=11
                     /translation="MRKSLFKPVIALIALTVLGTTAGCGTSDDSQGAPVRFSGPRSGAA
                     MQTAPADKNSLVQMPTHPINFQETSKVGGAGGNTPIAVTTYHGKKSGFTGKVWVWAPPE
                     YYEKKNANKGFPVMEALPGAYGYPVNYWIGSDLKLEESLATWSKAGKSLPFIVVMPVLN
                     PNDKQYYDGSDIPGQPKIGTWLSKDVPELVRENFRTLKTRNAWCIMGSSSGGFSALKNV
                     LQNPNDFKVAIPNGPDIVPDSPLWRGHLKEMRENNPEVLAHRLIARGGPEVYLAFQDGS
                     RENTVLPKVRKFIAQYGHGPVRTRLQIVPNGTHSGQTYVTGLGMGTMQWVSAHMQGPTG
                     "
     gene            complement(22817..22999)
                     /locus_tag="O1M07_RS17180"
                     /old_locus_tag="O1M07_17175"
     CDS             complement(22817..22999)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS17180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_17175"
                     /product="hypothetical protein"
                     /protein_id="WP_189856093.1"
                     /transl_table=11
                     /translation="MSTQNTPRTITVGTVTTAQSAGVGWATVTTGWGGGATRGFTAYVG
                     LESHPITLQDVDCGQ"
     gene            complement(23108..23968)
                     /locus_tag="O1M07_RS17185"
                     /old_locus_tag="O1M07_17180"
     CDS             complement(23108..23968)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088370.1"
                     /locus_tag="O1M07_RS17185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_17180"
                     /product="ABC transporter permease"
                     /protein_id="WP_039636297.1"
                     /transl_table=11
                     /translation="MTATTPAAAPGYRARRTLPLRVEARRQLRRRRTLVIGAILTLLPF
                     VLVAAFAIGGDPGTRNTGRISLMTTATASGANFAATALFVSAGFLLVVPVALFCGDTVA
                     SEASWASLRYLLAAPVPRARLLLSKLTVGLVFSAAAMLLLPLVALAVGTAAYGWGPLQL
                     PTGGALAPGDAVLRLALVTGYVFVSQLVTAALAFWLSTVTDAPLGAVGGAVGLTIVGNV
                     LDQVTALGDWRAVLPAHWQYSWADALQPQLEWSGMLQGASVSVSYALVLVALAFRGFAR
                     KDVVS"
     misc_feature    24051..24065
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
ORIGIN
        1 ggtccagctt cgcacgctgc ggaactccgc tgagtgacgg ccgtccccat aggcccaagg
       61 ctcttcgctc cgcttgtcgc agcttctcca gctcagaacc ggataccaac gctccgcgcc
      121 tgcatccggg cggcggcaag cgttccggct gtgccgagaa cgacaccaaa taccgatccc
      181 ctgcccgcaa cgtacacggc cataagcgct atgacggctt gcccacaaat ccgcaaccta
      241 ctttggcgcg catagcttgg gaactgcccc ccaagtgcct agtgatcgat cttaaaacga
      301 cgcatcgaga ttgtctcttg acgaagctga tgggtgaaat cgacgctgcg cgctactcga
      361 tcaataccct ttgtcctgtt cccgcgaagt gaagctcgat atgtcctgtc gagcaaacca
      421 gtcatctgtt caagcaactc gtcagagaga tgctcaatct taacgttcag gaagtccctc
      481 tgcgtaggcc tacgcagccg agtaagcgta aacctagcca tgtaggcaag gtgatacctc
      541 cagttctccg aggtgtcacc gagcagagtc ttgaactcgc gatacgagtt caggaactcg
      601 ctaatccgga tatgaacgtc gaggactaga cgatagaggt caagatcatt ctccaccgaa
      661 aagaccttat aatagtggtc gtcatccaga agcagcgatt ccgggagctt gagtgccacg
      721 tgaggctcac ccacgacaaa agcggtgtat tccctggcga gtcgcgacat gctgactact
      781 tgttctagcc ggaatccgag attcttgtaa tagttcgccc gccgttcgta atagtaggag
      841 tccctctgca gagattcttc gatatccttc tgaatctgtt cagtcgcgcg aagggcacct
      901 ggcgggagct gagtctggct gttcgtcgcc ctgatgattg cgtctctcgc acgtccagat
      961 ttagggggaa ccatgatccg cacgagaatg caacgatcac gatgattctg cgcagatccc
     1021 tggaagtatt tatagatctc atgactggtt tgcaggccgt taacgatctg cgggtctttc
     1081 attacgatct tcttgccagc gattcgaact tcttcggcca caatggttac tccattattg
     1141 aaccaccaga agtcttctcg atgattattt ttgagcgtct cgccaatttc ggtatttacc
     1201 gacgtgcgtc cagcataatc gcgaacgtta gactcgaaaa gctccaggcg cagagcctcg
     1261 ttaggtgaag tgatgaaatt atagtactca tcgaggcgcg ccaagcatac gtatccttca
     1321 ccaagcgagg tgctcatcgg agtctccgtg aagacaagtt cggagacaac taccgcaccc
     1381 cgcgccgaca atgcccgcag ctccgccgct cccaggtact caacagagca tttcgtttca
     1441 gatgcaatct ttgccagctc cgcagcaagc ctgtttccct ttgcgcgcac attcgggtgg
     1501 ggtccctcgg ctgcacggct cgcatagatg accctgacga aaaccttagg aaacgacgaa
     1561 gccaacgcct caagcacgtt caagaatcgg ccagtacgat ccaacagctt cgcattagtc
     1621 gactgagcta aatcggcgat attgcgattc atatcaagaa gaagcggcaa atgatagtgc
     1681 agcttctcga aggcagtttc ctgatatccg gatgccgtct tcgcctgaag gatgacgagt
     1741 tcaatctttc ccgcacgtac attcgcgtga cgggcaatgt ccgcggatac ataccggtca
     1801 tcaacgagaa cccagatccc atcgatgccg caatcgtgcg agccgtctac gattccgtca
     1861 cgcaattcat cgatatcgag gtctagatcc tgcaatgctg tacttgccgt gaaatagtta
     1921 aaaaaatcat ccagcttttg atccggcgca agccggctgt gctggtcttc gagaacgcgg
     1981 tccaagagac gctggtcatt actcctcgaa gccatatttc ccccacgatc cgtcccagca
     2041 cgtgacggcc aattctgccg atcgtcaacg cagcacgcaa gccatacgac ctaaatggca
     2101 acacatgatt tcgaacaagc gttttgatga atcgtttcgc ggagcctgtg acatccaggg
     2161 agcgcacgtg gcaggtcgtc ttgccgcgcc tctacgcaca ggcgcggagc cgatggactc
     2221 tgtggcgggc cgagctcctc cggaagcatg gttccatgag ccgaaggcga ctccctctct
     2281 cctcgcaatc aagatcattc gcctggggga gcaccctgtc gaatacgtgt cgaagttgct
     2341 ccggcgcaga acgctcgaca caagaaaggt ccaggtcagg gggccgcgaa cgataaaccg
     2401 caccagtccc ttctaagcac ttggccgcag gttcgagtcc tgccgggggc gccagaccag
     2461 accctccttc gggagggtct ttttgctggt cagcgctgtg gtgcggcatg gcgaggtctt
     2521 cggggtgcgt gtgggttgcg gccccagggg tgctgtttct gccgggtgcg ttccgcgctc
     2581 gcgggaagtc gcaggtccgg gcgtgcggga ggctgtcgtg tcgggggctg cctgctggcc
     2641 gcaggtttga gtcctgtgtg gggctcaccg cggagtggaa gggttcagtt cgtttccaca
     2701 ggtcatctgg tctgcggggc ggtcaaaaag cccgggtggc gtgtgtgcgg gcatgaaccc
     2761 gaggggaccc atggcatggg aactcaggtc agctgccggc tacttggagg agggggcttc
     2821 gtcgccttcc tcgcatccgc tctgcggttc gggcgtccgc gtactcgacg tgacggtact
     2881 tggggaagag gcgggtatcc ggcaggctcg tgacacggtc gcgaatcatg gcgatgtccg
     2941 ggtccggcgg ttgcggcgcg cagttgcagg cgccgacgcg acgcgcggtc gccggcgagt
     3001 tgttcccgta ccggcgcgag cagttcatcg cgggtcagtg tttccggcag gggtgggttg
     3061 ccgggtatgg atagccgcga cgtcgggtgg gcctagggcc tgtccgacgg gtcagggccg
     3121 ggtccgcggc gtctggcacg gccttgccga ccctgaccca tcggacaggc cctagtcgag
     3181 ccggttcgcc gcgacgttct cggcaccgac cgcccctctt ccgcgaagtc cgctgcctcg
     3241 gcgccctcca ggacgtggag atgatcattg gtcgtgaagt cgacggtgga agggcagggg
     3301 cggagatgga aggggtcggg aggggacgat gtcgtgggct cgggtggctg gggtgtcttt
     3361 ggtgcgtccc ggtgggcggg cgggggcttt cggggtgagg tggaggggcg agcacgctcc
     3421 tcttacgcga gcgcgggcct gttgggggcg gatcccggtg ggtcttccag gtgtctgggc
     3481 cgggcagggg gctggtccag gcaggagctg ggccgggcaa ggggctggtt cgggcggggc
     3541 ccggggcttc gtggctgggc gtggctgttc ggttgcggtc ggggtgggta aggccggaat
     3601 ctgggggatt ttcgcaatct tctagaatgc ggggtggaag attctcgggg tttcccggga
     3661 ccgtcccggc tcttcagtcg gccgtgggca tgggcagggg catgggcagg ggcatcgcga
     3721 ccgagaatcc gtggatccgg gtgtctttgg cccgtgaaat cggggagcat cgatgagcac
     3781 taccgggcgc ggattcttct cgcggggcag agctttgttt ccgggcagag cctggttccg
     3841 gggcagggtc tggttccgga gcggggcgtt cttccggttt cgtggtgagg gggtgggcgg
     3901 acgccgtgct gcgttcgctg tcgacggggt ggtcgtcgcg gcggccaccg cggagttgct
     3961 gactctctac gatgcgctcg acgggctctc ggcgctcgtg tgcccgccgt cgctgttcgc
     4021 gctggtgctg cgccgccgct tcccggtggc cgtgctgttc gccaccttgc cgtccatggc
     4081 caccggccac ctgtggctgg ctcccatgat cgccatgttc acggtggcgt ccaggaccgc
     4141 ccgccgtgcc gtcgtcggcg tcgcgacggc cgcgctgttc gcggcgacca tgtggtccgg
     4201 ttacgacctc gacggcgggg cggtggactg gagccaccat ctgttcgtgg tcgaggtggc
     4261 tctcatgttc agcgtcggcc ccgccgggct cgggctgctc tttcgcaccc gatccgagct
     4321 gcgggccagg ctcgcggacc tgatcgcctc ccaggcacac ggccgccgtc tggaagccga
     4381 gcgggccgtg gcggaggagc gcacccgtat ggcccgcgag atgcacgaca gcgtttcgta
     4441 ccacctgggc atcatcgccg cgcagtccgg cgccctgtgg gcgaccgccc ccgacgacac
     4501 cgtccggcgg gatgccgaga ccatacgccg ccacagcgcc gacgccatgg cggagctgcg
     4561 ggagatcgtc ggcgttctgc ggcacgggcc gagccgggcg gacgggacgg acgcccggct
     4621 ccgcaacgtg ccgaccctgg tggcggaagc ccgcctggac gcgacgctcg actgtggtgc
     4681 tctggaggcc cacaccctcg ccccctccgt ggaacgagcc gcctaccgaa cggttcagga
     4741 ggcgctcacc aacgtccgca agcatgctcc cggtgccccg gtcgccgcct ccgtacggcc
     4801 ctcggcccgg ggcgacgcgc tcgtcgtcga ggtccgtaac cagccggcgc cccggacgcc
     4861 tccgtcggtc gcccccgtgc tcgacgtgcc cgcgagcggc tacggcctcg ccgggttgag
     4921 ggaacgcgtc actctcgtcg gcggcgcgtt ccgggcggag gccactgcgg acggcgggtt
     4981 cgtggtgcgt gccgagttgc cgctcgggcc cgccgctccc cccgcgtcgg ggccggcgcc
     5041 gggcgatcag cccgcgaccg ccgcccaggg cgagtcgggg tcccgctcgt agaccgacac
     5101 gtgtcgcagg ctggcggagg tgtacggggt gccgcaccag tcctccgtgc gttcgacgag
     5161 ccgtagcccg gacagctcgg ccagcagatc gatctcgaag gggaaggcgt agcgcagtac
     5221 gtgctcacgg gtggccgggg ctccgccgtc gatgatggtg tgcgtcgaga gcatgagctg
     5281 ttgcgagcgg tccacggcga gcgtgtccag catgacggcg tgctcgtcga ggtggcgcat
     5341 cgagaagtcc ggcttctcca ggtggtggta cggcgccggg tcgaacgcct ccaggacgaa
     5401 ccggccctcg ggcgcgagct gttcgcggac ccgtcgcagg gtgccgagct gctgttcctt
     5461 cgtgatcgcg acgaagaagg tgttcagcag gagggtcacg gtgtcgaaga caccgccggt
     5521 gccttcttcg gtgaagtcac cgaactgggt ggtcaccgcg gtccgcgggt gctgcttgtg
     5581 cagctcgtcc agcatggcct cggagccgtc gatgccgtgc acccgaaagc cgcgctcggc
     5641 gagcggaacc gcgatccggc cggtgccgac gcccagttcc aggatgctcc cgtcgggcgg
     5701 cgtgcggccg gccacaaact cgaccgcctg ggcggtgtcg tggtcgatcg ggtacatgcg
     5761 gtcgtagacg ctcgccagtt tccggtcgta gagcgcgttg ccgagtgcca tggtggttca
     5821 actccagacg gcggggtgag gggatgggtt cgggggccgg cccgccgccg ttcgggcgtt
     5881 cagcgggtct cggccagggc cgacggacgc aggtggcctt ccgtggcggc gcggtgtgcc
     5941 gccacggcgg cctggacgcg attggccagc cccagtttcg tcaggatcga gctgacgtgc
     6001 tccttcgccg tcgaggcgct cagcagcagt cggcgcccga tgtccgcgtt ggtcaggccc
     6061 tcccccagca gttcgagcac ctgcagctcc cgctcggtga gcgtgtccag gcgcgggtcc
     6121 cgctcgccgt ggcgcggacc ggcgccgagg tagccgtcga cgacgatgcg tgccgcggcc
     6181 ggggagagca cggttccgcc cgatgccaac acgcggacgg cgtcggcgag ttcctgcggt
     6241 gtcgcgtcct tcagcaggaa gcctgccgca cccgagcgca gcgccgccgc gacgtcctcg
     6301 tcccgcagga acgtcgtgag gacggcgacc gcgggcgggt cctggtgggc ccggatccat
     6361 tcgagggcgg tgagtccgtc gacctccggc atgcgcaggt cgagcaggac cacgtcgggc
     6421 cggtgcgccg ccacggcttc gcggacctcc cgcccgtcgc aggcgaccgg cacttcgatg
     6481 tccgcttcgc tctccagaat gcgctgcatg cacgaccgca gcagaatttc atcgtcgacg
     6541 atcatcaccc ggatcatcca cgccccccgt cagagcatcc ctaatcggtc aaacctcgtt
     6601 caaggtacca acagacaagg gattcgagag cgcggggccg gaaaggcagc gcgatggaaa
     6661 tcgttttcgc cgtgttttct cggagcgggt cagacgggct cggagaggcg ctccgtgatg
     6721 agctccacca gcttcgcgtc ccaggtggag acgagcagtt cgatcttctt cgcggagccg
     6781 ccctcggccg tcacggtgca gtccagggcc gttccgaagc gcccgccgcc ggtcgccgcg
     6841 gcggccggac cggacagcgc cagtgctctt gggccgggcc cgtccaggac gaccccggac
     6901 gagctcacca cgattctccc gcgatgcgtg gcggggccct gtgcccgaat gcggaaccgg
     6961 cagcgcagcg tgatcctttc accgcgccga aaggcggcga tacgacgcgc cgaacgtacc
     7021 ctgtcaagac tcttgccgcc tatccagaac accgtgtcca tcagagaaaa caggacgaat
     7081 tccagaagca tgtgattgcc cctcaactca actcgggatg gctgctcgta caaaacccgg
     7141 ggccctcgtc ggcccggcgc acggcccggt cctgcatcgc ccccacgatg gcccgcacgt
     7201 cggccagcgc ggcgtcgagc ccttcggtca gcaggacccc cgcacagctc agcgcgatct
     7261 ccgtggcccc cgcttcaccg tagccggtga gccggtccgc cagctcgtca ggggtgccgt
     7321 aggcgaagac cccgctgtcg accagcacgc cggccccggc ccacgggtcg gccgcgtcca
     7381 cgccgaggcc cgccgagcgg agcatcgccg cgtagtgctc accgcccagg tgcagctcgt
     7441 gcgccgcgaa cgcgagccgg cgcgggtccc ggccgggctt gcgcaccgcg cacggcacga
     7501 tcgacgtcac cccggggacc gccctgtccc gggaggcggc gccgcgggcg agcgcgggca
     7561 cgatctggtc cctgaggtgg gtggccggcg tcagcagggt gatcgccacg tcggcgacct
     7621 ggcccgccgt gtacgccatg cgcggccgca gcacgccgac gccgagcgag acgggagggt
     7681 gggggacctg ggggagcccc tcgtccacgc gcacatagcg cccctggaag tccaccaact
     7741 cgccgtccag gagccgtcgc acgacggtca ggtactcggc gacggcggtg cgcggacttg
     7801 cgtacggtgc gccgcgcagc gccgtcacga acgccgggtc gccggtgctg tagccggcga
     7861 cgacgtcggc gccggtcagc agggccagcg acctggcctg tatcgccgcg tccagcgggt
     7921 ggcgcagagc agtcagggcc acgctggtgc cgaccggcac gcggatgccg cgcccggcga
     7981 ggtgcgcgaa ggcatggtgg gtgtcgacca gcaccgactg ccccatgtag agccgctcca
     8041 gggacagctc ccggacgact tcgccgaagg cggtgaggtg gtccaggtcg tacgccatga
     8101 gcgggtacat gagggacagc gggggtgttc gggtcatggg tgcttcctgt gcggcggcgg
     8161 tcatgcggag gctcccggca ggtaggcgtc ggcctggagc cggaagaggt gggcgtaggt
     8221 cccgccgcgt gcgagcagtt cctcgtgggt cccctcttcg atgagcgaac cgccctccac
     8281 gaccaggatc ttgtcggcga tgcggacggt ggagaaccgg tgggagatca ccagggacgt
     8341 cgcccgggag cagatcgtgc gcagccggcc gaagatgtcg gcctcggcct cggcgtcgat
     8401 cgcggcggtc ggctcgtcga ggatcgcgat cggcgcgtcc cgcaggaagg cccgcgccag
     8461 ggcgatcttc tgccactggc cgccggacag ctggtggccg ccctcgaagt gccgtcccag
     8521 tgtggtgtcg taggtgtccg cgaggcggtc gatgaactcg gcggcgccgc tggacccggc
     8581 cgctgcgcgg aggcgggcgt cgtcgtcgag gtgttcgagg cggccgaagc cgatgttgtg
     8641 ccggacgggc atctcgtagc ggatgaagtc ctggaagacg accccgatgt tccgctggag
     8701 gtcgtcggtg tcgtactcct cgagaggcac gccgtcgacg aggatgcggc cgctggtcgg
     8761 ctcgtagagg cgggagagca gtttgacgat ggtgctcttg cccgcgccgt tcgcgccgac
     8821 gatcgcgcag caggtgtcgg cggggatgaa gcaactgaac cggtcgaggg cggtggtcgt
     8881 ggtgccgggg taccggaagg tgacgtcctg gaactcgatg ccgtgcgtca ggcgccgcgg
     8941 gaagggccgg gtgccgcccg tgatgcgccc gtcgggcagc gtcagatagt cgaagaggtt
     9001 ccccgtgaac agcgtgttct ggtacagggt ggccacgccg agcagcagcc cggtggccgc
     9061 cgcgtgcacc gcgcccagcg cctgcaggta cccggcgagc tcgccgatcc ggccgttgtc
     9121 cgcggtggat ctgagggcga agaccagcgc gcccgccgag cagcccacgc tgaccaggcc
     9181 gagcgtcgcc gaccagccgt gccggcggcg tgccagcgcc cggtcgacgc ggaagaactc
     9241 ctgcacgagg gaccggtagc ggcctacgag atgggggccg agttgataca gcttcacctc
     9301 cttgtaggag gagtccgtcg tcgtaaggtc ctggtagtag aaggcgcggc gccggtcctg
     9361 cgcacggtgg tactcgatcg cgtagccctg cttgctgaac accacgtgcg cggcgagcgc
     9421 gggcaacggc gccagcagga tggccagggc gatccagacg ttccaggaga acagcaccca
     9481 gctgaccatc accagtgatg ccagcgcggt gagcgtgcgc atcatctcct cgaacacctc
     9541 gaaggccgtg ccgctgccgc tctcccgcag cgcgcgctgc agtcggtcgt acgcctccgg
     9601 gtcctcgtag gcgctgaggt ccatgcgggt gcccttgacc atgacccgct caccgatctt
     9661 ggccgtgaac tccaactgga gcagggagtt caggtactgc gcgagcgacg tcaggatgtg
     9721 ctccgccacc gagaccgcga cgagaccggc cgcggcgaag gtgagccggt ccatggcgtc
     9781 cggcacccgc gtgagggcgt cgacgacggc ctgcacggcc ctggcggtca gccagatccc
     9841 ggtggccggc acggcggcgg tgagtgccgt ggccacggcg agcgcggaga ccctcagggg
     9901 gctgagtccc cagaacgtgc gcaggacgag ccaccagtag cgcaggtccc gggagaggcg
     9961 ccggtgctcc tcgggcacgg tctggccgct ggcttcctga tcagtcacgg ggcctccccc
    10021 gcaggcagtt caggacgtgc ccccagatca ggtagcagcg gtcctcggcg gggcggtcca
    10081 tgggcagcag ccggttcacc tgcatgtgcg cgaggctggc caggacggcg tcccgggtgc
    10141 cccacagcgt tccggccgcc tccgcgtccg cgacggcccg cgaggcccgg cggacggcgt
    10201 cgacctgacc ggcgagaacc ggggcgaggc gctcgtggtg ggcacggccc ccgaggtgcg
    10261 ggcggcggtc ccagggggcg agcagctcgc acagatagtc gcggtccttc ttgtaccgct
    10321 cgcgggcctc cctgtcctcg gcgggccggg gcatggcggc gagacgctca cggacatcga
    10381 gaccccactg ggcgtacagc gcgtcgacgg cggccagcgt gaccgcttcg gccgtgagtc
    10441 cgggctcctt gtcccagagg agaccgagca gttgggcgga gacggcgctg ttcgccgcga
    10501 agaactcctc gatgtggtcg tacacggcgg gaccgccgta ccggctcacc tcggggtggt
    10561 acgtggcgac ctccaggcgc tcggcgatcc cccgccggac gagggagcgc ccccagtcca
    10621 ggagcggttc cagggcggac gtgccgccgg ccggtgtccg ggtcctgatg cgcaggtgcg
    10681 cgtcggggtc ggcgtaccgg atgtagaacc agcggtcgac gtcggcgcct gcgtcccgta
    10741 tctcctggac gagtccggcc agttcgaccg cggcgatctc gtcgtgcagg tcacgggcgg
    10801 cgtacagctt gaggtacgac cactcggagc cgggcagatg gctggggtgg gcggcgggac
    10861 gggccttgcg ccgtatgccc tcggccgcgg cctcgcgggc cggagccgtg tccggtggcg
    10921 gcgcggcctc ggtgccgtcg ggcgcggcca ggagcgggat gacgacctcg gccaggtgcc
    10981 cgcgtccggc gctgtcgcgc agccaggtcc tgtcgggatc cggcagcgcc tcctggagcg
    11041 tgacccgctc gtcggccgcc cgcagatcgg tcaacagctc gtccgcacag gccgggtggt
    11101 cgaggtccag gagcagccgg ttgtcgtcgt cggccaggta gacgtggcgg ggaacgcccc
    11161 aggtgcggcg ccactccgtc aactccgcgg cggtgcgcgg tacggggacg ggagcggtgt
    11221 ccagcggggc ccgcgcgccg gtcgggtaca ggttccactc ggcggcccgt acgacgaccc
    11281 tgccccgcac gacgcgcggc aggtacgggg cgccctcgac cgggccccag gtgaagccgg
    11341 tgggcatcgc atacctggcg cgcgagacct ccagcaggaa ccggcacacg ttgggcgcgc
    11401 cgagcgggct gagcatgtgg ttctggacga ccaccagttc gcgcccgagc cgtgccgagt
    11461 agagccgcag gccgtcgtcg gtcgcgccga cgtggatgtc ggagaggtcg atgatccggt
    11521 ccggggcggc ggagggtgcg acgttgaccg ggatctcgta gccgtggacg gcgggccgga
    11581 tcgccacgtt ggcgccgcgc ccgttgccgg gcaggtacgc cagctcggcg acgacgacgt
    11641 cgggctccag ggcttcccgg gcacgggcgt aggagcggag gcgttcggcg gcggagggcc
    11701 cgaggaggtg gaagaaccgt ccgaaggtgc gtccgccctc gccgagaccg tcgctgttga
    11761 gcacggcacg ccagtcgccg tcgtcgatcg cgcgggcact ggacgcggcg atctggacgt
    11821 acgcgtcgac gccggggcac ccgcgccggg cgtcgccctc gtcggcgggg acgagcctgc
    11881 gcagcacctc gtcgctcagc tcgacctcgt cggctccgct ccgccacgcc tgggaggcca
    11941 gggcgaccag ggcccgcgcg gtccgcgggt ctccttcgcc gccggtctgg tgcatgacca
    12001 tggcgcgggg tggatcgagg tagctgttgg gggcgtcgag gccgcgctcg gcgctgagga
    12061 gttcgaggac ggggacgagg gcgtcgcttc cgtaccgctc catgaacgcc tcgtgatacg
    12121 gcgcgaggtg gtcgtatccg ccgggcgccg cccggcccag ccgcgccagg cagccgacgg
    12181 cctcggcgac ctcgtcggcg acctggcggt tgatggccgt atcggcgagg ccgagggcgg
    12241 agtcgacctg gaagggctgg tgtcggtact cggggacgag ggtgcgttgg gccaggcgca
    12301 gcctgtcgag cgcgccggtg tcgtcgtgga cggcggtccg ggtcatgtcg acgacctcgc
    12361 gcagtccggc cacggcgggg tgctccaccc cggcggcggt gagccgggcc aggacgtacg
    12421 cctccgggca gggatccgtg acgggcggcc gcaggtcggt gacgagcagc ccgaggccga
    12481 ccagttcggc gacgaacgcg gagatccgct cgtgcccgac ggccgggaac cggtcggtca
    12541 gttcggcgac cacctcggca tacgggacgg gcgcggcggc cggggcgagg cgccggacat
    12601 ggctgagcgg gctggtgtgc cgtacccgca ccgatcgccg gtcggcgttg ccgtgcacat
    12661 ccgaggaagg caggacgagc cggtcaccca cccggtgcgc catagcgttc atggacacgc
    12721 tgagccgttc gagcacctcc ggcgcgccct ccaggtcctt caccagagcg agcagccatc
    12781 ccatgtcggc ccgcacccgg gcggacacga agggggtcgc gccgagccgg gcggtggtgg
    12841 tctcgccgaa ggagccgagt gcgacgccgg agaaggcccc gaagggggtg gggcgggtgc
    12901 tcatgcgggt gagatagcgc agggcccggg agtggacgcg ccgcgtctcc ttgccgctcg
    12961 cgcgtccctg tgcggcctcg accttggcca gcccgtcgag cagtccgctg ccggcggcga
    13021 cgagcccgtg gcgtacgcgg gggttgtcgg ccatggcgcg caaccgggcg cgggtgcggg
    13081 tgaggtcgcg gtcggcgagc gtctcccgcc agacctcgac cggcagggca ggtgcccgca
    13141 ggagagggaa gtcgagggct tcgtaccgcg gcatggggcg tgtcaggtcc ttgtcgattg
    13201 cgttcaccgg agaaagagca cccgccacca actgggcctg cggccggtgg ccgtggcgcg
    13261 gagggtcagg gcgacaccgg ccgcgccggt gaggagcccg ggattgtcga cgacgtgccc
    13321 ggtggtctcg tggtcgcggt acaccagggc ccgctcgggc tcggcggcgt cgagcagctc
    13381 cgtcacgagc cgggcgagtc cacgcgcggc gccctcgctg ccccgcgcag cgaactcgtg
    13441 ggcgagcgcg acgcatccgg cgaggccgtg gcacacggtg ggcgagcgag gcacgtcccc
    13501 ggcggcgacc cggtcgagca gcccgtccag cgcggcgaac gcccgtgctt ccagggcccg
    13561 gtcgccggtc gcgtcggcta cggtgagcag cccgacggcc actcccccgg tcccgtggca
    13621 ccaggcgggc acggcttcgt ctccgtcgtc gaggcgcggg tccacgggga cggaccgcgg
    13681 ccactggagc tgtcggcctc cgcggctgcc gacctccagc agccacgcca ccagccggtc
    13741 gaggacgagg cgttgcccgg gcagccggtg accgtgccgc caggccgtgg ccagggcggc
    13801 ggcgataccc gcagcgccgt gggacattcc ggtgtcgagc cgcccctcga cggcccaccg
    13861 ctgatcggca ccgacccaca acaggtaccg caggcaccgt tgaagcgcct gctcgacgag
    13921 cggggtcgtg gggcggacgc gacacaggtg ggcgaggacg cccgcgcacc cgtagacgag
    13981 gtcgtagtgg tgagcggcga cggcaccggg ccggcggggc agctccatgg ccagggcctg
    14041 ccgggacagc tgttcgtcca gtgcggcgag gctgggcaga aaacggggct cgtcggccgc
    14101 gacctcgcgc agcacgaagg cgaggccggc cgtgccgtcg aagagccccg ggtgcgtgag
    14161 cgcgtcctct tgggtggcgg cgaaggcagc gcgcacgaag gagaaggcca ggtcgcgcga
    14221 ccactcccct tccgcgccgc gctccgcggt acgggcggcg tggaggtgga ggagcgccag
    14281 cccggcgtgc ccctcgctga gggaagcgcc gttccagaag gacagctcgc tctgcccggc
    14341 ggcgcgtgcg gcgtgcgcat cggcgccggc ggggctgtcg agtcgttccc ggatcacgct
    14401 cgcgacggcg ttggcgcggg cggcaagttc gggcggcagg agggggctgg ggtgcatgtg
    14461 tggggctcta caggttcttc ggagggggtc ctccgtttcc ttccggagga ccccaccgtg
    14521 gtgatcggac gcgatcggca gcgcggtcag cacttgccgt tcgtgcggac ggcggcgcag
    14581 gcggccgtca tcttgatcgt ctgccggatg gtctgcttga cggcccactt gctggcgacg
    14641 cgcgaggcga cgctggcaac cggggacagc gacgtctgag ccgggtcggc ggaaacgatc
    14701 acgcgagcgt cgaggttgaa ctcgtccatg aattcacagc acctttcatt ccatagaacc
    14761 aaccgcccac cgaggaaacg aggaaggggt tccacaggag ttcccgaggc ggtcagagaa
    14821 tgaatttaat gaggccgagg acgctcttga acccgccgac cgtccctttc ttcccccacc
    14881 atgtggcggg acggtccgcc cggctgaccg gtgcccgacc gtcagcgccc ctgcagggcg
    14941 tccagcccaa ctgccatgca gagcgcgagt gtccggtcca accccggatc ctggatacgg
    15001 cggcaaagtg acgagcggca cgaccaggtc gacgacatcc cacgcgcgtc gcgcaagcgc
    15061 cacgccgacc cgccgctcct tgcccacggc ggcgctctcc ttcccctgcg tcagatgcca
    15121 agtggaccgc agaaaagacg ccttgaagtc cttgcggaag ctgccgatga gatccccacc
    15181 ggtccctgtc acgtcgtacg tggccccgag gtcgatcacc tcccgcgcct tgaatccgcc
    15241 gagttcccgg gaacggtcct catcggtcca caaggtcagc tgctcctgca acgcgaaccg
    15301 cttctgctcc gcgaaggcga tgacctcacc gctttccgga agcgtgaaca cataccggtt
    15361 cacgagcggg gcgatcttct gcgtcatgag aatgtcgtcg ggctgccaca tgcaggaacc
    15421 gtaaacatcg gcagaacgcg cgctcgtgca tctcaaggtg gagcggcacc ccgccgaccg
    15481 gaggggtacg gagggccgag tggccacctg tccctcccga attccctcat ggatccggcc
    15541 tttcataaag gacccacatt ccaccgggcc cacattccac cgaagaggac gcccagggtt
    15601 ccggggagta cggccgcgcc ggtcagggtg tcgcgttccg gaccgacccg gtgtcgtggt
    15661 ggacgagcga ggggtagtcg tcgagggaga tgtcggcgga gatgtcgtgg ccctcctgga
    15721 gcatggccgt gagggcggcc gggtcgttga gcgcggagtt gcgggccgct atcgcctcct
    15781 gagtgagggg ggccaggaac gcgccggttc cgcggccgcc ttcctgacag cgcgagacat
    15841 acggccgcag cttctgctcg taccgggcga aggctcggcg gtggtcgccg gccgcgaggg
    15901 ccagttcgcc ggcgaggaca taggcgccga cgatcgccga gcccgtgccc atcccgccga
    15961 cggtggcgcc ataggcggcg tcaccgagca gcgctatccg accccgtgac catgtcggtg
    16021 cgtcgacgcg gcttatggcg tcgaaataga ggtcgtcggc atcccggacg gtcccgacga
    16081 gttccgcggt gcgccagccc gctccctcgt acgcccggac gagggccgtg cgctgggcct
    16141 gggggtcgcg gcggtcgtgg cccagtcgct cggaggcgaa gacgcagaat gcctcgcccg
    16201 cgtaggaggg gtcggcggcg cggcggggca cgcggccgac cgtcaccagt cggccgggct
    16261 cgttgtaacc gacggcgtgg gcggcaaggt ccggtgccgc gccgtgcggg agatcccagc
    16321 cggcgacgta gtagccgagg tggctgacga agtcctcttc ggggccgaag gcgagccggc
    16381 gcactgtgga gtgcaggccg tcggcgccga tgaccaggtc gaaggtgcgg ggcggggcgt
    16441 gctcgaaggt gacatggacg ccgtcggcgg tttcggtgag agaggtgagg gagtcgccga
    16501 agaggtaggc ggtgccggcg ccggcggcag gggtggcggt gtcgtcgtga agggtgggag
    16561 tggggcggct gtggtcgtag aggatgcggg agagttccga gcggaggatc tccacgtcgc
    16621 ccccggcgaa ctcgggtggg agggccgcca catgattccc ccgggcgtcg atgaaggtca
    16681 tcgaagcacc gccggtgcgg cgctgcctga tctcctccag gacgcccatc ttccgcagta
    16741 ccgccaggtg cgccgcaccg cggaagtcga ccgcgaagcc gccgccgcgg agggccggcg
    16801 cccactcgac cacggtgggg cggtagccat agcgggcgag ccaatgggcg agggccgggc
    16861 cggcgatgct ggcgccggag atgaggaccg ttcgggcccg cgcggcgggg gtcggcgtcg
    16921 gttcgcacct ctcgcgcgcc ccgtacgccc ctcgcgtctc acgtgccttg tccgtgtggt
    16981 gcggtgtcgt ttcgcgcgtc atcggacgct ccccctgtgt ctgcgtggtg tggcgacaca
    17041 acaactgtat ccaccggaca cagatctgta tacccccgga cacagtttta ggatgcggag
    17101 gtggctggag acgagaagag cagtgcgttc ggggatcagg cgggcagcgt ggagctgctg
    17161 tggggcgggc gcgagcggcc gagccggggc cccaagccgg cgctgagcct ggagcggatc
    17221 acgcggacgg ccatcaacct cgccgacacc ggcgggctcg gcgcggtctc catgcaacgg
    17281 gtcgcggcgg agctggactt cacgaagatg tcgctgtacc ggtacgtgcc cggcaaggcg
    17341 gagctggtcg ccctgatgat cgacacggcg atgggtgaac cgccggagcc ggcgggcgcc
    17401 gcggccggcg actggcgggg cgcgctgcgg gactgggcgc agcggctcgc ggcggtcttc
    17461 gcccagcatc catggctgct gagcgccctc gtcgggccgc gggtcatggg ccccaacgaa
    17521 ctcggctgga cggagcgcgc actggcggcg ctcgcgggca ccgggctgac cggcggcgag
    17581 cagctggatg ccgtgctggt ggtgagcggg cacgtccggt ccatcgccca ggtgtcggcg
    17641 tcgatggggg tgggcggcgc ccccgcgaag gagccggagg cggcgctgag cgccgcgctg
    17701 aacgagctgc tcgtcgggcg gtccgagcgg ttccccgcgc tgagcgccgc gctggcgggc
    17761 gccgcccggg gcgaatcccg ggaccaggct tgggagttcg ggctggagcg gatcctggac
    17821 gggctggagg cgtacgcagg acgggtgtga ggcccgccca ccctgcgtac gccccgcggg
    17881 gccctcgtcg tagcgctaca tccccagccg cacggacttc cgcggccctt ccttggcgcc
    17941 ggtcaggagg ccgtggaggg tggcgaactc gtcgacgcac ttggcggtgc cgttgaccac
    18001 gcagtccagc ggggcgtcgg cgaccacgac cgggacgccc atctcctcgc ggaggcggcg
    18061 gtccagcccc cggagcaggg cgccgccgcc ggtgagggcg atgccgcgct cgatgatgtc
    18121 gccggagagc tccggcgggc agtcgtccag ggtgttgtgg acggcgcgga cgatggcctc
    18181 gacgggttcg gcgagggcgg cgcggatctc ttcggcggtg atctcctgga ggcgcgggag
    18241 gccgctgagg tggtcccgcc cgcggacggt gtaggagtgg ggggaggggc gcgccgcccg
    18301 gtccgcgggc gactcggcgt cggcctcggc gtcggacgcg gggtcggaaa cggagtcgga
    18361 cgcggcgccc acggcgaggc gggtggggag cgggcggtcg tcgtccgggg tccagaccgc
    18421 cgagccgatg gcgatcttga tgtcctcggc ggtgcgctcg ccgatggcca ggccgtgctc
    18481 cttcttgatg tacgtggaga tggcggcgtc catcgcgtca ccggcgaccc gcacggactg
    18541 ggcggtgacc aggccgccca tggagaccac ggcgacctcg gtagtaccgc cgccgatgtc
    18601 gacgaccatg cagccgaccg gttcggccac cgggaggccc gcgccgatcg cggcggccat
    18661 cggctcctcg atcaggtgca cctcacgggc accggcgccc cgtgcggagt cgatgacggc
    18721 gcgccgttcg accccggtga tgccggaggg gacgcagatg acgacccggg ggcgggagaa
    18781 gcggcggctg ggcagggcct tcttcatcag ggcgcgcagc atctgctcgg ccgcgtcgaa
    18841 gtcggcgatg acgccctccc tgaggggacg catcgcggtg atcccggagg gcgtgcggcc
    18901 gatggtgcgt ttggcctccg aaccgacggc gacgacgtcg ccggcggcgt tgacggcgac
    18961 cacggagggc tcgttcagca ccacgccttt gccgcgcgcg tagacgaggg tgttggcggt
    19021 gccgaggtcg atgcctatgt cgtacgtacc ggacgaagtg ctggacgcca tggggagttc
    19081 gcttgctctc tctcgggagg acagtgcgcc gcggcgagcg tcattgacgc accaatgacg
    19141 ctaattacgg gcaattatct agactactgg gggtgcggaa tggttcctgc gggggcggat
    19201 gcgcccgggt gcggaagcgg tcgggggcgg gtcgtcaggg gtcggggggc agtgcctcgg
    19261 cgaggtcgtc gagggcgtcc aggagcagtt cggtggcgcg gacggcgacg ccctcgtgct
    19321 cgtcctcggc gctccaccgc tcccaggcgg cgtgcggctc gccccagtcc atcgcctcgc
    19381 cgtcgcggac ggcccggacg gcgcggtcca gggcggggcg gagggcggcg gcgaacgcgg
    19441 cggcgccggg cgagggccgg gcgtcccggt cgggcgggtg cgcctccagg atcatcgtga
    19501 cccggcccat ggtggcgagc gcggcgctgg cggcgtgcgc cccgccgagc gggaggccgc
    19561 ggtgccggac cggctccttc tcggcgcggg cctcggtcgc ctcccaggcg gcgcgggccg
    19621 cgcgggcgtc gagcagggcc tcgcggacct gccggggccg gcgctcggcg ggccgggcgt
    19681 agccgtcgac gacggcgagc gcgtaacggc cgttggtggc cagccagtcg gcgaggcggt
    19741 cgcggagccg gggtgtctcc caggcgggga acagcgcgta ggacagcatc gcgaggaccc
    19801 cgccgatgag ggtgagcacg aggcgttcct ggacggtctg ttcccagccg gcgccgacga
    19861 tgccgagcag gaagacgaca taggccgcga tgcaggcgga ggtgacggag aagccggtgc
    19921 gcatcagcag gtacatcagg aagacgcaga gcagggcgag ggcggcgctg acgtaggcgc
    19981 cggggtgggc cagcgccatc agggcgccgg ccagggtcac gccgacgacg gtgccggcga
    20041 agcgggcgac gccgcgggag taggtctggg cgaagtcggg gcgcatcacc atgacggagg
    20101 cgagcggggc ccagtagccg tggccgaagt ggagggcggc gccgagcagg tagccggcga
    20161 cggcgaccgc ggcgacgcgg agcgcgtgcc gcagcacgtg cgaggaccag cgggcctcgc
    20221 ggcgcagggc gcgcagggcg accgggacga gccgggggac gctggggcgc agcaggtggc
    20281 cgcgttcggc ctcggtggtg gggcgggtgg cctcgacggg ctcgtcggtg agttcgacgg
    20341 cgtcggcgag gagggagatc aggcggtagg cggtgcgccg ggcggggccg cggagcatcg
    20401 ggccgctggc cgggacttcg agggcggcca tcgcctccgg tggcagccgg accgggctgg
    20461 cgtgccgcac ggcgtgcgcg acggcgtcca ggacggtggc ggcggcgccc aggagttcac
    20521 gggcgcggtc gcgttcgggc ccttccaagg gggcaccgac gaccgggtcg gccagtgagg
    20581 cgaggaccgg gcggacgcgt tcggcgaggc cgcgcgggcc gtgcagctgt acggggcggc
    20641 ggcgggcctg gcggggtgtc acggtggcgg cggcccgggc gtccatcagg ggcgcggggt
    20701 cgaacggggc gaccgggtcg tgccgcagcc ggcgggcgta gtcggcctcg gcggccagcg
    20761 cgtcggcgag ggtgtcgcgc tggatgcccc agggacgcac cgggaagagg acgatgaggg
    20821 cggcctggac gaggccgccg caggcgatca gcgcggcgtg ttcgagggcg cccaggacgg
    20881 acgtcgggag ggtgacggtg atcagcatga tcgccacggt ctgggtgccg acgaggccgg
    20941 agaccggccc gatcgcccag gccatgcccg ccaggagggt ccagccggtg agcagcagga
    21001 cgaaccagac gacgtgggcg gcggccaggt agccgaggaa ggtggagatc gccagcgcgc
    21061 cggcgacggc cagtgccagg accgggcggg gccgcatgct gcgctggaag gtgacgatgc
    21121 cggcggagaa ggcaccgaag gcggaggaga ccgcgagggc ggggttgccg cgccacaggc
    21181 acaggccgag gacgacggcc acgccgaccg tgccgcggat cgcgatcagc ggggtgagct
    21241 tggcgcgttc gatggtcagc ccggagcggg tggcttcctt cagcgcacgc gaccaggtca
    21301 tagcgagagg atacgggccg ggagcggggg cggcggggtg ccgggcgacg ggtgcgggag
    21361 ggcgacccgg atgccttcgc ggcgcgttcc cgaggggtcg ccgcggaccc tcgaaggggc
    21421 gtgcggaggg gtgccggagg cggcggccgg cgccggggcg cggacgcacg cccggtgtgc
    21481 cggaaggggg cgcgcggggg tccatcgggc gcccgtgttg cgcctccacc aggaaaatca
    21541 cggtaaaccg gatctccgtt gcgcgtaaac atcacaggtc agagccggtc ggcgagtttc
    21601 gttcccgagg gtgcgagcaa gcagacactc cgggagggaa acctgtgccg gccccgcccc
    21661 ctcttgttgg ccggtcggga caactcccgg ctcgttcgcc aaggagaagg tcccgtgcgc
    21721 aaatcccttt tcaaaccggt gatcgccttg atcgccctga ccgtactcgg caccacggcc
    21781 ggctgtggga cgagcgacga ctcccagggc gcgcccgtac ggttcagcgg tccgcgatcg
    21841 ggtgccgcca tgcagaccgc gccggccgac aagaactcgc tggtgcagat gcccacccat
    21901 ccgatcaact tccaggagac cagcaaggtc ggtggggccg gtgggaacac cccgatagcc
    21961 gtgaccacct accacgggaa gaagtccggc ttcacgggga aggtgtgggt ctgggcaccg
    22021 ccggagtact acgagaagaa gaacgcgaac aagggcttcc cggtcatgga ggcgctgccc
    22081 ggcgcctacg gctacccggt caactactgg atcggctccg acctcaagct ggaggagagc
    22141 ctcgccacct ggtcgaaggc cggcaagagc ctgccgttca tcgtggtgat gccggtgctc
    22201 aaccccaacg acaagcagta ctacgacggc agtgacatcc cgggccagcc gaagatcggc
    22261 acctggctga gcaaggacgt ccccgagctc gtccgggaga acttccgcac cctgaagacc
    22321 cgcaacgcct ggtgcatcat gggctcctcg tcaggcggct tctcggcgct gaagaacgtg
    22381 ctgcagaacc cgaacgactt caaggtggcg atccccaacg ggccggacat cgtcccggac
    22441 tcgccgctgt ggcggggcca cctcaaggag atgcgcgaga acaaccccga ggtgctggcg
    22501 caccggctga tcgcccgcgg ggggccggag gtctacctgg ccttccagga cggctcccgg
    22561 gagaacaccg tgctgccgaa ggtgcggaag ttcatcgcgc agtacggcca cgggccggtg
    22621 cggacgcggc tgcagatcgt gccgaacggc acgcacagcg gccagaccta cgtcacgggc
    22681 ctgggcatgg gcacgatgca gtgggtcagc gcccacatgc aggggccgac cggctgagca
    22741 cgggccggcc ggcgggcggt cgcggcggac atccggtccg cggcgaccgt cctcgtcgta
    22801 tgtcggggcg ggcggttcac tgcccgcagt cgacgtcctg gagcgtgatc gggtgcgact
    22861 ccaggccgac gtaggcggtg aagccgcggg tggcgccgcc gccccagccg gtggtgacgg
    22921 tggcccaacc gacgcccgcg gactgggcgg tggtgaccgt gccgacggtg atcgtccgcg
    22981 gggtgttctg cgtagacaca cgggtccggc gcgtggttgc ggcgccggac aacccgaacg
    23041 aagggggacg ggtgtccgca tccggccgcg ccgcccggcg gccccgcggc ccctctcccc
    23101 gccccggtca ggacaccacg tccttgcggg cgaagccgcg gaaggccagt gcgacgagca
    23161 ccagcgcgta ggacaccgac accgaggcgc cctggagcat cccggaccat tccagctggg
    23221 gttggagggc gtccgcccag gagtactgcc agtgcgcggg cagcaccgcg cgccagtcgc
    23281 cgagcgcggt gacctggtcg aggacgttgc cgacgatggt cagtccgacg gcgccgccga
    23341 ccgcgcccag cggcgcatcg gtcaccgtgg acagccagaa cgccagcgcc gcggtgacca
    23401 gttgactgac gaagacatag ccggtcacca gcgccagccg cagcaccgcg tcgcccgggg
    23461 cgagcgcgcc cccggtgggc agttgcagcg ggccccagcc gtacgcggcg gtgcccaccg
    23521 ccagcgcgac cagcggcagc agcagcatcg cggcggcgct gaacaccagc cccacggtca
    23581 gcttgctcag cagcagccgg gcccgcggca ccggcgcggc caacagatag cgcagcgacg
    23641 cccagctcgc ctccgaggcc acggtgtccc cgcagaacag cgcgaccggc accaccagca
    23701 ggaagccggc ggagacgaac agcgcggtgg cggcgaagtt ggcgccggaa gcggtggcgg
    23761 tggtcatcag actgatccgg ccggtgttcc gggtgccggg atcgccgccg atcgcgaacg
    23821 ccgcgaccag gacgaacggc agcagcgtca ggatcgcgcc gatcaccagg gtgcggcggc
    23881 ggcgcagctg gcggcgggcc tcgacgcgca gcggcagggt gcggcgggcg cggtagccgg
    23941 gcgccgccgc cggggtggtc gcggtcatcg tccgtctcct ccgatcaggg tgaggaaggc
    24001 gtcctccagg cggcggtgcg ggccgacgcg gtgcaccggg acctccagcc ggacgagttc
    24061 ggccagcagg tgcggggtgc cgtccggcgc ggccagccgg accagcaggc cctcgtcgga
    24121 gcggaccgcc gagaccacac cgggcagcgc gtcgaccttc tccaccaccg cgtcgggcag
    24181 cggcgcggcg gcgccgacgt cgatcagcac ggtgtcgccg gagcccacga tctcgccgac
    24241 cgggccggcc tggaccagcc ggccgcggtc catcacgacc aggtgggtgc agctctgctc
    24301 gacctcggac agcagatggc tggagacgat gacggtgcgc ccggccgcgg cgtaacggat
    24361 catcacctcg cgcatctcgc ggatctgcgg cgggtccagg ccgttggtcg gctcgtcgag
    24421 gatcagcagg tccggaaggc cgagcatggc ctgggcg
//
