LOCUS       NZ_JAPTYM010000001     24535 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2414473
            Orig. end                         :: 2439008
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24535
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="16"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24535
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14535](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14535)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            86..613
                     /locus_tag="O1M07_RS10795"
                     /old_locus_tag="O1M07_10790"
     CDS             86..613
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.5"
                     /locus_tag="O1M07_RS10795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10790"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_372516462.1"
                     /sec_met_domain="APH (E-value: 3.4e-11, bitscore: 42.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVPVDRFLAELAEPLTAIHRITGTHIGRLAGARQHRSWTDYLHDR
                     LHMYARAAPALRTTARILRQEVEAVESSTQPVLLHHDLQSGHLLREPAGSRLLIDWELA
                     VFGDEQSDLGRLAVRLDLDDPTPVLAIASRSDPTAEGRLHLYWHIHLLADAALSTDPVI
                     RERAAARLPRRR"
     misc_feature    complement(849..866)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     misc_feature    963..977
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            1034..1825
                     /locus_tag="O1M07_RS10800"
                     /old_locus_tag="O1M07_10795"
     CDS             1034..1825
                     /NRPS_PKS="Domain: Abhydrolase_1 (1-102). E-value: 2.1e-17.
                     Score: 55.5. Matches aSDomain:
                     nrpspksdomains_O1M07_RS10800_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="O1M07_RS10800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10795"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_189857023.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.5e-13, bitscore:
                     48.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.2e-14, bitscore: 51.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMHGLGLSGRYLSPVARQLAAAGRTVVVPDLPGSVRSRFAVRSMP
                     DIPELAAALGRWHTAAGLGRCAVVAHSVGCQVSTAFAARHPELVSRMVLIGPALDPSAP
                     CLWRQLGRLLADASHEPVPLVSMAVADYLVTGPVRFLIGFRRALGDAEGPYRQRLSEMD
                     VPTLVIRGSGDTLAPMEWTRYAASLLPRGRVAVVHGAAHAAHFSAPESVAALIEDFLHE
                     ACEGAEGSPGRGLSHQGVPYEGVLDGDPTPAAEAMMEGSAE"
     aSDomain        1037..1339
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1M07_RS10800_Abhydrolase_1.1"
                     /evalue="2.10E-17"
                     /label="O1M07_RS10800_Abhydrolase_1.1"
                     /locus_tag="O1M07_RS10800"
                     /protein_end="102"
                     /protein_start="1"
                     /score="55.5"
                     /tool="antismash"
                     /translation="MHGLGLSGRYLSPVARQLAAAGRTVVVPDLPGSVRSRFAVRSMPD
                     IPELAAALGRWHTAAGLGRCAVVAHSVGCQVSTAFAARHPELVSRMVLIGPALDPS"
     gene            1822..4122
                     /locus_tag="O1M07_RS10805"
                     /old_locus_tag="O1M07_10800"
     CDS             1822..4122
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.5"
                     /locus_tag="O1M07_RS10805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10800"
                     /product="MMPL family transporter"
                     /protein_id="WP_189856771.1"
                     /transl_table=11
                     /translation="MNRVPWVVRLARATATRPGVVVHCWLLVAVLAVLQIPSFTEHETP
                     RTARVEGSESARAEDLLSSAFPHLGPEVGGIVFHSPTLTADDPRYRTAVAAVALSVQAD
                     PAVQRTVSPFSVAGRVSKDGRTALTGVFFRGSKGDVQRAAPRLQELVRRSTALVQRGGE
                     RRIEAYLVGYSAAFSEIITQEKAGTRQAELIGVPLALLLLLLATGTAVAACVPIVLAAA
                     GVLLSFGVVGAVSRLTGFDATLETIIPMMGLALGIDYALYVVSRFRAELAERRVDPATP
                     SPEVVRDAVAAAMRHAGTTIAASGLVFMLGMSGLLFIDAPTIRQIGVGAMIAAACTLLA
                     GLTLLPALLALAGHRLEYGRLPWRSRVPGSLAETGSPRFAAFAQRVMARPVAVTVLAAA
                     LLGVLALPTLDLRLGVDLGVPALKGTAVGKGQRLMERGFAPGRSMPIDLVYTCAGGRLS
                     QRDLDAVDRLSTRLARDPAVYSVDSVTTLAQPGQAPVRATPDTLRATAKHVLVSADSRS
                     TVLSVAPAAASDSAAAMQLVGRLRTEIIPGALADVPGARVLVGGMTAAHRDLSDETTGK
                     LWPVLGFILGLSFVFLVAVFRSILVPVKALLMNVLATLAAYGVTVWVFQFGHLEGPLDF
                     RSTGTIQAFLPLLTFAFLFAVSMDYELFLVRRVQESWRRSGDNSAAVVEGVAHTAVPIT
                     AAAATMAAVFGSFVMVDVLEIKQIGFALAVAVLLDVTLVRMLLVPAVMRLAGRVNWWFP
                     RWGLRRRAGREPW"
     gene            complement(4186..4761)
                     /locus_tag="O1M07_RS10810"
                     /old_locus_tag="O1M07_10805"
     CDS             complement(4186..4761)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS10810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_10805"
                     /product="hypothetical protein"
                     /protein_id="WP_189856773.1"
                     /transl_table=11
                     /translation="MATVTTFGGEQKAQAVPQAELLCPLVTATVNYNTGFSSELVRPFT
                     EAIETSNNILLGTEAGDGTVTCLDGRLPVPALRVTGGHGTLTGTKVGNCENVDVQKSTA
                     RIVWTHRQPDGTDVVVGKSTITYAASGPIEDTVITSGFVSGGDTFLDDKIVNNSINDGN
                     TDATAKACATTAGVKTQTGKAQFTLEKY"
     gene            4754..4996
                     /locus_tag="O1M07_RS10815"
                     /old_locus_tag="O1M07_10810"
     CDS             4754..4996
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS10815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_10810"
                     /product="hypothetical protein"
                     /protein_id="WP_189856776.1"
                     /transl_table=11
                     /translation="MAMPSARADAAYAAFFIGDRFAAVDLLAERMSATSFCRWPRIDED
                     ADDHRKDPVESDFLAGLIVRAAALLDKGSPWGASG"
     misc_feature    complement(4789..4805)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.12"
                     /tool="antismash"
     gene            complement(5386..6556)
                     /locus_tag="O1M07_RS10820"
                     /old_locus_tag="O1M07_10815"
                     /pseudo=""
     CDS             complement(5386..6556)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611170.1"
                     /locus_tag="O1M07_RS10820"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10815"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGTYKYSAEFRADAVALARSSGRPVSRIAAELGVNHETLRQWFKT
                     AENAEWPESVSQSTKDAEFTALRKQVRELEMERDILRRAAKYFAGETNW"
     misc_feature    6655..6664
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.75"
                     /tool="antismash"
     misc_feature    6833..6844
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.47"
                     /tool="antismash"
     gene            6994..7827
                     /locus_tag="O1M07_RS10825"
                     /old_locus_tag="O1M07_10820"
     CDS             6994..7827
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611183.1"
                     /locus_tag="O1M07_RS10825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10820"
                     /product="IS5 family transposase"
                     /protein_id="WP_189856778.1"
                     /transl_table=11
                     /translation="MNRGCGVARPKPWEVDDALWAVIEPLLPKVERRTRHPGRKRHPDR
                     LVFQGILFVLHTGISWEHLPQELGFGSGMTCWRRLAEWSKAKVWPRLHEVLLAKLRSAN
                     ALDFSRAAVDGSHIRALKGGSKTGRSPVDRGRTGSKHHLITDATGIPLAATLTGGNRND
                     VTQLIPLLEAVPPVRGKRGRPRRRPDVVLGHRGYDHDKYRRMVRDLGVKPLIACRGTEH
                     GSGLGTQRWVVERAFAHLHWFRRLRIRWEIRDDIHEAFLTLGCALICWRRLRSCC"
     gene            complement(7833..8213)
                     /locus_tag="O1M07_RS10830"
                     /old_locus_tag="O1M07_10825"
     CDS             complement(7833..8213)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998284.1"
                     /locus_tag="O1M07_RS10830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10825"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_189856780.1"
                     /transl_table=11
                     /translation="MTTDAFLADCRARLAFDLLSNTWNAVVLWALRDGPRRPVELRERI
                     GGISSKVLTETLRRLQFNGLVDRQAHPDASSRVEYQLTALGRTLLAPIDAVGAWAFEHG
                     DEVMAAQEAACAPDPQSARSTC"
     gene            8288..8971
                     /locus_tag="O1M07_RS10835"
                     /old_locus_tag="O1M07_10830"
     CDS             8288..8971
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539311.1"
                     /locus_tag="O1M07_RS10835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10830"
                     /product="NADPH-dependent F420 reductase"
                     /protein_id="WP_189856782.1"
                     /transl_table=11
                     /translation="MRIGVLGTGNMADALATHWVRAGHEVIIGGRDAHKAERLATRIGG
                     SVKPASLCVAAESGEVVLAALPFGAGVDVARDLHAALEGKVLLDCSNPVGPGFRLLTEG
                     GPSAAQQLAAAAPGAHVVKAFNLCHEDVWRMRPPVFDGRPLAVPICGDDETAVARVREL
                     VQDVGCKPVAGGGLERAGLLEATAALFIALWVGEGADAQAIAPPLAYAAGPSHQETEGG
                     TRAFR"
     gene            complement(9111..9632)
                     /locus_tag="O1M07_RS10840"
                     /old_locus_tag="O1M07_10835"
     CDS             complement(9111..9632)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS10840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_10835"
                     /product="hypothetical protein"
                     /protein_id="WP_189856784.1"
                     /transl_table=11
                     /translation="MARRFPAARGIALSTGVAAVALVGFATVHDSGAAAFLLALASACG
                     PVVTVLLATAQIRMTPAELQGRVNSGTGFLAQAVSPLGPTLAAVCTHAFGLFPTVLGAA
                     SLVVLLALVGGAVAARHLHVPPPATGGRTVADGAGADRADVRGTDDAEPTATGRQRGAG
                     EQKPTVRNYG"
     gene            complement(10001..11407)
                     /locus_tag="O1M07_RS10845"
                     /old_locus_tag="O1M07_10840"
     CDS             complement(10001..11407)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="O1M07_RS10845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10840"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_189856786.1"
                     /sec_met_domain="LANC_like (E-value: 1.8e-35, bitscore:
                     121.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPRALCDAASDTAHRVAELLSSPERVAGAARGAFAALPSDVPP
                     PAWQPASLLLGHPGIALLHTRCARDDARYAAIGHAHLAAAVAATTDAGPAAVGDLLLPA
                     RLHAHAHGGYTRLLARSAEVHAAYVGARVARLVTRRQEHGPGLAYGDYDVISGLAGQAR
                     GLLAAADDGDERCAQVLDDVLGFLVGMTHPVRPAEGDGSQVPGWWCAPDRYLLARDRAE
                     FPRGDLNVGVAHGICGPLALMSLAYRAGHRVPGMRDALRRMADWVLGVGRADDRGSQWP
                     GRVAAYSKAPGEPSPPPPRRRPSGTAGGSSSPGWCYGTSGIAWTLQLAGQALDDHRLTA
                     LARDAVRGLVHRPRDAVTAVDPGFCHGRAGILHIVGRMAAAGGSTELWAAADALARELV
                     ADFDARTPFGYRQVLPPSGTSRPAPHRVHHPGLLDGAAGIALALADYADARRGTAPEDT
                     TGWDAAFLMS"
     gene            complement(11404..14535)
                     /locus_tag="O1M07_RS10850"
                     /old_locus_tag="O1M07_10845"
     CDS             complement(11404..14535)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="O1M07_RS10850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10845"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_189856788.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-171,
                     bitscore: 570.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.4e-12,
                     bitscore: 46.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-40, bitscore:
                     138.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAAALPLPPEDGPGGRSRPSDAAPYDEDRLRRRIAELAADPRLM
                     EAVSLASAGLAAEVDRAVAGERLRLRSLRRIALSLTKYHSRMSHRPTPFGLFAGVGLAA
                     FGPAPAREPIGGGRRVTRPDAAWLDGVLETLLDVPAVLERSRLTANNLHVVRDGRLVLV
                     DHHDRDGERQLAGSVRHTRVVRQLLAAAAHPTPHPRLVAAAGREFPHAPRGAIEGSIRQ
                     LVRGHFLLGDLTPPPDCTAPLDHVCDRLRGVDHPTAHELHALRAELRSLDAAPPDGRRA
                     RLTAVGERMRAMRPAADVLQTDLAPTVRLTLPQEVAREAERAATVLWRTSPVHRGNPHL
                     RDYHLDFLERYGTERSVPVLELLDEVRGLGLPRDYRRPPASPPAAGAGTRDLVLGELLM
                     AAARGGGREVVLDEETVRALEPAERGAAPPSMEVGAELVTPGWDALCGGDFHLVLAPDA
                     VSPLAGATFSRFAPVLGRSAAQVRELALRTERSAPQDEIPACVAFRPRVMRSANVSAVP
                     QWLSHRIPLGVGPAAAETAHDLRVEHLVVCADTDGLRLVDTVTGRRVRPLSYSMLNPSG
                     RHLPYVARFLLEIGQEGRSFCAPWSWGGWAAAPALPRVRHGRTVLSPARWLPDRALRAA
                     ADRGDQEWSGQVGRWRRRWDVPRQVLLTKADHRVAVDLDDPLHLLVFRDEVRRAPGLTV
                     VERFAGPAERQWFRGPEGAHAAEFFFPVFARPTGVRARPTGPDTARGTRPAGPVAAPVP
                     LRSGDAAAGCGARAHPPGGEWLYAKIHVPRARQPEVLARHLGPLTDPGLLRRAGVDRWF
                     FVRYEDPAPHIRLRFHGTPESLWPVLLPELHAWARAREEAGVLGKVVLDTYEPEVERYG
                     GPAALTHAERFFHADSEAVVALLAGSAARPDDPTPKAAPGILDIVTRLGSPDEALGWLS
                     SPAVLARRGDIPRERKQAVAALLDSRARPRPPAATDGGDAGWSARAAALSDLREALSAG
                     APDPGRRARIALSLTHMHVNRLLGPGPEQELTAQVTAREALALWLARKRNRNTG"
     aSDomain        complement(13828..14094)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_O1M07_RS10850_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.70E-15"
                     /identifier="RREFam001.1"
                     /label="O1M07_RS10850"
                     /locus_tag="O1M07_RS10850"
                     /protein_end="236"
                     /protein_start="147"
                     /score="46.4"
                     /tool="antismash"
                     /translation="TANNLHVVRDGRLVLVDHHDRDGERQLAGSVRHTRVVRQLLAAAA
                     HPTPHPRLVAAAGREFPHAPRGAIEGSIRQLVRGHFLLGDLTPP"
     gene            complement(14687..14833)
                     /locus_tag="O1M07_RS10855"
                     /old_locus_tag="O1M07_10850"
     CDS             complement(14687..14833)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS10855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_10850"
                     /product="hypothetical protein"
                     /protein_id="WP_189856790.1"
                     /transl_table=11
                     /translation="MENATISMDEFDLDLDVDIMDSATVAGDAQESKLMTQVCPSTSWR
                     CGW"
     misc_feature    complement(14960..14969)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(15203..15216)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.63"
                     /tool="antismash"
     gene            15345..15602
                     /locus_tag="O1M07_RS10860"
                     /old_locus_tag="O1M07_10855"
     CDS             15345..15602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576619.1"
                     /locus_tag="O1M07_RS10860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10855"
                     /product="hypothetical protein"
                     /protein_id="WP_189856792.1"
                     /transl_table=11
                     /translation="MTAHRDPDTIAADLAELRRLLDVRTATVDGQLRLQAQRCEQNTRD
                     ADELQARITRLESRRWPLPSLAALAGLAAGAAALWQAYGR"
     misc_feature    15384..15386
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15615..16145)
                     /locus_tag="O1M07_RS10865"
                     /old_locus_tag="O1M07_10860"
     CDS             complement(15615..16145)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607568.1"
                     /locus_tag="O1M07_RS10865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10860"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_039637920.1"
                     /transl_table=11
                     /translation="MRWNNLSEKPVYANPWFRVNLADVELPDGRHLDHFLIRMRPVAVA
                     TAVNEANEVLLLWRHRFITDSWGWELAAGVVEDGEDPVAAAAREMEEETGWRPGPLQHL
                     LSVEPSNGLTDARHHIYWSDRAEYLGAPQDDFESDRREWIDLKLVPDMVARGEVPAANM
                     AAALLMLHHIRLG"
     gene            complement(16194..17531)
                     /locus_tag="O1M07_RS10870"
                     /old_locus_tag="O1M07_10865"
     CDS             complement(16194..17531)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989068.1"
                     /locus_tag="O1M07_RS10870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10865"
                     /product="lipopolysaccharide assembly protein LapB"
                     /protein_id="WP_189856794.1"
                     /transl_table=11
                     /translation="MEPNTLLDAILDEAGISHAGLATRINHLGRRRGLALRYEHTAVAR
                     WLKGQRPRGQVPDLICEILGERLHRPVGLADIGLSGPGARQAPGTPLSGFVERATALWR
                     SDEQQRPHVVAAPALTGTSAIIPVWEWENPPEDFDVSRDGVTRVGMADIEMLRVARTHY
                     EQMYRKAGGIATRARIVGFLNTEAAPLLRGSYSDATGRQLHRATGGLVAVAGICAYDSD
                     ALGLAQRYFHQALRLAKASGDRGLGAYVIALLVNQSLFVREYRQAVAFAEAALRTSGGQ
                     LTPALSADLYAMQAKAYARLGDGAGALDCIRRAEAAAERIRPGLEPAETGYVQPGLVNV
                     QVAEALLSLGDLRSAREQADAAVDTPAHDRGRVHRLAMLTHIELRQGDADRAVANAAEM
                     TEQARGMESQRLRDRLRAVREHLAETGSAATDEAADLIDEVLRVPL"
     gene            complement(17703..20282)
                     /gene="pheT"
                     /locus_tag="O1M07_RS10875"
                     /old_locus_tag="O1M07_10870"
     CDS             complement(17703..20282)
                     /EC_number="6.1.1.20"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pheT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607573.1"
                     /locus_tag="O1M07_RS10875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10870"
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="WP_189856796.1"
                     /transl_table=11
                     /translation="MRVPLSWLREYVDLPATTTGRDVQEKLIAVGLEVETVEQLGEGLS
                     GPLVVGQVLTIEELEGFKKPIRFCTVDVGQANGTGEPQEIVCGARNFAVGDKVVVVLPG
                     AVLPGDFKIAARKTYGKKSHGMICSGDELGMGDDGSGGIIVLPPATEVGIDAIELLELR
                     DEVLDIAVTPDRGYCLSMRGVAREAAIAFGLPLRDPALLDVAPPNAGGYPVQVGDPIGC
                     DRFTARTVTGLDPEARTPIWMQRRLQKAGMRPVSLAVDITNYVMLELGQPLHAYDRTTV
                     EGPIGVRRATPGEELVTLDGTKRVLDGEDLVITDNRGPIGLAGVMGGANTEIAAPVADP
                     ETGRVHGTTDVVIEAAHFDAISIARTARRHRLSSEAAKRFERGVDPEAASAAAQRTVDL
                     LVLLAGGTAEEGVTEVVSPRGPRTITIPADHPDKVAGVTYGRETVVRRLQQVGCDVYGN
                     SAAWNAPLGGGGRETGGKDELVVTVPSWRPDLGDPNDLAEEVIRLEGYENLPSTLPLPP
                     AGRGLTERQRLHRRVGRALAGAGYVETLNYPFTGPAVLDQLGIEPDDPRRDAVTLVNPL
                     SDEEPDLRTTLIPGLLASLRRNYGRGNHDLALFETGPVFRATGTELPARRLVVDRRPTD
                     DEIAALDASLPQQPRRAAVVLAGAREQAGWWGAGYPSGWADAVEAGRAVAREAGVELIV
                     RQDQHAPWHPGRCAALLALVDGEEVLVGNAGELHPRVVKTLGLPERTSAMEIDLDRLER
                     AAAGSLQAPRISTFPVATQDVALIVDASVAAADVETALRDGAGELLESVRLFDVFTGEQ
                     VGDGRKSLAYALRFRADDRTLTAEEATAARDAAVAVAVERVGAALRG"
     gene            complement(20282..21405)
                     /gene="pheS"
                     /locus_tag="O1M07_RS10880"
                     /old_locus_tag="O1M07_10875"
                     /pseudo=""
     CDS             complement(20282..21405)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pheS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524136.1"
                     /locus_tag="O1M07_RS10880"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10875"
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSAPNKSYDPVEVEALKPEEIARRVDEALAAIAAAGDLDALAQAK
                     IAHAGGTSPLALANREIGALPRRPRRTPASASARPAAGSTRRSRPARKSWRRSVTRASW
                     SRRRWTSPCRTTGSRPAPGTR"
     gene            complement(21625..22740)
                     /locus_tag="O1M07_RS10885"
                     /old_locus_tag="O1M07_10880"
     CDS             complement(21625..22740)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576624.1"
                     /locus_tag="O1M07_RS10885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10880"
                     /product="PAS domain-containing sensor histidine kinase"
                     /protein_id="WP_189856798.1"
                     /transl_table=11
                     /translation="MTARTSASTATAGGCPPEESGADLGLAPDDLPDGLVVADEHGRVI
                     CFNAAAARITGIEPPQALGRPVGDALPLQDIEGRRWWQLTDPYGGLAIRRGQPERNLLL
                     GGREVLVSARYVRSRPTGPVRRLVIALRGTEARRRTELSHAELIATVAHELRSPLTSVK
                     GFTATLLQKWERFTDDQKRLMLETVDADANRVTRLIAELLDISRIDSGRLEVRRQRVDM
                     IAAVRRHVQAQTTAGQLPDRFLIRMMEPLPDLWADPDKVDQVLGNLLENAVRHGEGTVT
                     IEVGPAEETGGGEGTSVTVSDEGPGIPEESMSRVFTRFWRGSKRGGTGLGLYIVKGIVE
                     AHGGTITVGRAPAGGAQFRFSLPVAAPAFLA"
     misc_feature    complement(22719..22733)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(22815..23678)
                     /locus_tag="O1M07_RS10890"
                     /old_locus_tag="O1M07_10885"
     CDS             complement(22815..23678)
                     /GO_function="GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0001510 - RNA methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540170.1"
                     /locus_tag="O1M07_RS10890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10885"
                     /product="RNA methyltransferase"
                     /protein_id="WP_189856800.1"
                     /transl_table=11
                     /translation="MGTPELISPRSPRVAAARRLARRHFRGKERRFIAEGPQAVREAVA
                     HRAGGSPTLIELFATVEAAERHAEIVEAARAAGALVHFADDRTVADVSQTVTPQGLVGV
                     CRFLDSPFEEILTARPRLVAVLANVRDPGNAGTVLRCADAAGADAVVLTDASVDLYNPK
                     SVRASVGSLFHLPVAVGVPVEQVVTGLQGAGVRILAADGAGDRDLDAELDAGSMGGPTA
                     WVFGNEAWGLPEETRALADAVVRVPIHGKAESLNLATAAAVCLYASARAQRTTGGCRAT
                     SPAGGA"
     misc_feature    complement(23826..23843)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.09"
                     /tool="antismash"
     misc_feature    complement(23837..23849)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.67"
                     /tool="antismash"
     gene            complement(23875..24261)
                     /gene="rplT"
                     /locus_tag="O1M07_RS10895"
                     /old_locus_tag="O1M07_10890"
     CDS             complement(23875..24261)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010476244.1"
                     /locus_tag="O1M07_RS10895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_10890"
                     /product="50S ribosomal protein L20"
                     /protein_id="WP_039637911.1"
                     /transl_table=11
                     /translation="MARVKRAVNAHKKRRAILEQASGYRGQRSRLYRKAKEQVTHSFVY
                     NYNDRKKRKGDFRQLWIQRINAAARANGMTYNRFIQGLKAASIEVDRKILADLAVNDAG
                     AFAALVEVAQKALPSDVNAPKAAA"
     misc_feature    24262..24279
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.87"
                     /tool="antismash"
ORIGIN
        1 gcaacgcgcc ccaggtcctc agctgctcgc cgcgtcctgg ggcggccccc cgccgtagac
       61 cgcgcaggct gtcgtccagg cggagctggt acccgtcgat cggttcctgg cggaacttgc
      121 cgaaccattg accgccatcc atcgcatcac gggcacccac atcggccgtc tcgccggcgc
      181 ccgacaacac cgcagctgga ccgactacct ccacgatcgt ctgcacatgt acgcgagggc
      241 cgcccccgcc ctgcggacca cggcccgaat cctccgccaa gaagtagagg ccgtggagag
      301 ttcgacccag cccgtgctgc tgcaccacga ccttcagtcg ggccacctcc ttcgcgaacc
      361 cgccggttcc cgactgctca tcgactggga gctggccgtc ttcggcgacg agcagtccga
      421 cctcggccgc ctcgccgtac gcctcgacct ggacgacccc acgcccgtcc tcgctatcgc
      481 cagccggtcg gatcccacgg ccgagggcag gctccatctc tactggcaca tccatctgct
      541 cgccgacgcc gcgctgagca cagaccccgt catacgagag cgagcagccg cgagactgcc
      601 gaggagacgg tgagcacgac gccctcgcga tcgcctggtc aggacccctg ttcgaccagg
      661 caagcccgtt gatcggtaag ttgccggtgg ccaggagtgt gggcgccggc gaggccctga
      721 cgcctacgaa gtggcctgcc gcacagcgaa cgctcacgga aggcggtggc cttgccgatg
      781 ctcgcggtcc gggcggctgc gcgtgggtga tggcggcgcc cgctgggaag tgcatccgtg
      841 cgccccggtt tacatgcggg caacctgttg cacgcctgac gctggtgtga cctgcccggc
      901 aaggtgaccg tgcgctccgc gggtggctgc gggcagcgca ggtgaggagg cccgggtgag
      961 gtccacaaga tatgcggggc tgtacacgcg ctggttcggt cccgctctct ccgtcggctc
     1021 tccggccatc gtcatgatgc atgggctcgg gctgtcgggc aggtatttga gtcccgtggc
     1081 acggcagttg gcggcggccg ggcgcaccgt cgtcgtgccc gacttgccgg gcagtgtgcg
     1141 gtcgcggttc gcggtccgct ccatgcctga cataccggag ttggcagcgg cgttggggcg
     1201 ttggcacacc gcggcgggcc tcggccggtg cgccgtggtg gcccactcgg tcgggtgcca
     1261 ggtctccacg gccttcgctg cccggcatcc ggagctcgtc tcccgtatgg tcctgatcgg
     1321 cccggcgctc gacccctctg cgccgtgcct atggcggcaa ctggggcggc tgctggcgga
     1381 tgcctcgcat gagcccgtcc cgctggtgtc gatggcggtc gcggactact tggtcacggg
     1441 gccggtccga ttcctgatcg gcttccgccg ggcccttggc gacgccgaag ggccgtatcg
     1501 ccaacgcctg tcggagatgg acgtgcccac gcttgtcatc cgtggttccg gcgacacgct
     1561 cgccccgatg gagtggacgc ggtacgcggc ctccctcctg ccgaggggaa gggtggcggt
     1621 ggtgcacggt gcggcgcacg cggcgcactt cagcgccccg gagagcgtgg ctgcgctgat
     1681 cgaggacttc ctgcacgaag cctgcgaagg cgctgaaggc tctccgggcc gaggcttgtc
     1741 gcaccaaggt gtgccgtacg agggcgtctt ggacggcgac cccacgcccg ctgcggaggc
     1801 aatgatggaa ggcagtgcgg agtgaaccgg gtgccgtggg tggtccggct ggcgcgcgcg
     1861 acagcgaccc ggcccggcgt cgtggtgcac tgctggctgc ttgtcgccgt gctcgccgtg
     1921 ttgcagattc cgtccttcac cgagcatgag acgccacgga cggcccgggt cgagggcagt
     1981 gaatccgcgc gcgcggagga cctgctgagc agcgccttcc cgcatctcgg tcccgaggtc
     2041 ggcgggatcg tcttccattc acccacgctg accgccgatg atccgcggta ccggacggcc
     2101 gtcgcggccg tcgcgctcag cgtgcaggcg gatcccgccg tgcagcgcac agtgtccccc
     2161 ttctccgtcg cgggcagggt gtccaaggac ggacgcaccg cgctgaccgg ggtcttcttc
     2221 cgcggcagca agggcgatgt gcaacgtgcg gcaccgcggt tgcaggagct ggtgcggcgc
     2281 tccacggcgc ttgtccagcg cggcggggag cgccggatcg aggcatatct ggtcggttac
     2341 tccgccgcgt tctccgagat catcacgcag gagaaggcgg gcacccggca agcggagttg
     2401 atcggcgttc ccctcgccct gctcctgttg ctgctcgcca cgggcacggc ggtcgccgcc
     2461 tgtgtgccga tcgtgctggc cgccgccggc gttctcctct cgttcggcgt ggtcggggcg
     2521 gtgagccggt tgaccggatt cgacgccacc ctggagacca tcatcccgat gatggggctg
     2581 gccctcggca tcgactatgc gctgtacgtc gtctcccggt tccgcgccga actcgccgag
     2641 cggcgcgtcg accccgcaac gccttccccg gaggtggtgc gggacgccgt ggccgccgcc
     2701 atgcgtcatg cggggacgac catcgcggcg tccggcctgg tgttcatgct gggcatgtcc
     2761 gggctgctgt tcatcgacgc gcccaccatc aggcagatcg gcgtgggcgc gatgatcgcg
     2821 gcggcctgca cgctgctcgc cgggctcacc ctgctgcccg cgctcctggc gctggccggc
     2881 caccggctgg agtacgggcg cctgccctgg cgcagccggg tgccgggttc cctggccgag
     2941 accggttcgc cgcggttcgc cgccttcgcc cagcgggtga tggccaggcc ggtcgccgtc
     3001 accgtgctcg ccgcggcgct gctcggcgtg ctcgccctgc ccaccctgga tctgcgcctg
     3061 ggggtcgacc tcggtgtacc ggcgctcaag gggacggcgg tcggcaaggg acagcgtctg
     3121 atggaacggg gcttcgcgcc gggccggtcc atgccgatcg acctcgtcta cacctgcgcg
     3181 ggcggccggt tgtcccagcg cgacctcgat gccgtcgacc ggctcagcac gcgattggcc
     3241 cgtgatcccg cggtgtactc cgtcgactcg gtgaccaccc tggcccaacc ggggcaggcg
     3301 ccggtgcggg ccaccccgga caccctccgg gccaccgcga agcacgttct ggtcagcgcg
     3361 gattcccgca gtacggtgct ttcggtcgcg ccggcggcgg cttccgacag cgccgcggcg
     3421 atgcagttgg tcggccggct gcgcacggag atcatccccg gggcgctcgc ggacgtgccc
     3481 ggggcgcggg tgctggtggg cggcatgacg gcggcgcacc gcgacctcag tgacgagacc
     3541 accggcaagc tgtggcccgt gctggggttt attctcggcc tttccttcgt cttcctcgtg
     3601 gccgtcttcc gcagcatcct ggttccggtc aaggcgttgc tgatgaatgt gctggccact
     3661 ctcgccgcct atggggtgac ggtatgggtg tttcagttcg gccacctgga agggccgttg
     3721 gattttcgta gcaccggcac tattcaggcg ttcttgccgc tgctcacctt cgcgttcctc
     3781 ttcgcggtct ccatggatta cgaactgttc ctggtccggc gggttcagga atcctggcgc
     3841 cgtagtggcg acaactcggc tgccgtcgtc gagggggtgg cgcacaccgc ggtgccgatc
     3901 actgcggccg ccgccaccat ggccgcggtg ttcggttcgt tcgtcatggt ggacgtactg
     3961 gagatcaaac agatcggttt cgccctggcg gtcgcggtcc tgctggatgt gacgctggtg
     4021 cggatgctgc tggtgcccgc ggtcatgcgg ctggccggcc gggtgaactg gtggttcccg
     4081 cgttggggac tccgccgaag ggccggtcga gagccgtggt gaacacggag acatggtgat
     4141 ggggcgggga tcccggtccc cgccccatcc gtcattcaga tgccgtcagt acttttccag
     4201 cgtgaactgt gcctttccgg tctgcgtctt gacgcccgcc gtagttgcgc aggctttcgc
     4261 tgtcgcatcc gtgttgccgt cgttgatgct gttgttgacg atcttgtcgt ccaggaacgt
     4321 gtctccgccc gacacgaatc cgctggtgat caccgtgtcc tcgatcggcc ccgaggcggc
     4381 ataggtgatc gtgctcttgc cgaccaccac atccgtcccg tcgggctgac ggtgggtcca
     4441 gacgatccgg gccgtggact tctggacgtc gacgttctcg cagttgccca ccttggtgcc
     4501 ggtgagcgtt ccgtggcccc cggtgactcg cagtgcgggg acaggcagcc gcccgtccag
     4561 acatgtgacc gtgccgtcgc ccgcctccgt gccgaggagg atgttgttgg aggtctcgat
     4621 ggcctcggtg aacggccgga ccagttccga ggagaaaccg gtgttgtagt tgacggtggc
     4681 cgtcacgaga ggacagagga gctcggcttg cgggaccgcc tgggccttct gttccccgcc
     4741 gaacgtggtg accgtggcca tgccaagcgc gagagcggac gcggcgtatg ccgccttctt
     4801 catcggtgac cgcttcgccg cggtcgacct gctggctgag cgcatgagcg caacctcatt
     4861 ctgtcgatgg ccgagaatcg acgaggacgc cgacgatcac cggaaagatc cggtagagtc
     4921 ggattttctc gccgggctca tcgtgcgcgc tgccgccctt ctcgataagg gctcaccgtg
     4981 gggcgcgagt ggctgaaaat aggcggccga gggtacgcca tagcgtgcag gaaagaggtc
     5041 gcgcccccga attaccgcac aaagcagccg aaatggggaa cggtatagcg tcgccctgtc
     5101 ggggctttcg tttggtacct cccgccgccc gaccggcagc gtcgacagca gaccgtgctg
     5161 cgtcccccga cccgcgtccg ctgcaacgga ccgtcggagc acaggcatac aggatcggac
     5221 gcgtcgcgcc gtccggtcag ccacgacgga ccgcccgtat ttcccacccc atgagtcatc
     5281 ggcgcgtgaa caccgcacca ccgggccgac ttcactcgaa tcgcgagacg catctttcgt
     5341 gggctgcacc agcggggctt ccaccctgat cgtggacacc ggttgtcatg cagcgatggc
     5401 cagcgtagtt gatctctgct cgaaggcggc cggggtgagg tagccgatcg tggagtgcct
     5461 gcgctggagg ttgtagaagc cgagccggcg gaagaccgcg agccgcgcgg ctcgttcggt
     5521 cggccagccg cgccggccgg gcaggatctc ccgcttcagc gaggcgaaga aagactccgc
     5581 ggcggcgttg tccgccgagg tgccgaccgc gcccatggaa cggcggatcc cggcctggcg
     5641 acaggcgtca gcgaatgcct tcgagccgta ctgcgccccg tgatcgctgt ggaagatgac
     5701 gtcgtccacc ctgcgccgcg ggtgcggatg gccgcgttga gcgcgtcggt gacgagctcg
     5761 gcccgcatgt gaccggccat cgaccagccc agcaggcgac gggagtacac atcgatgacg
     5821 gtggccagat acaggaactt cccgccagcg atgggcaggt aggtgatgtc gccgatccag
     5881 gcccggttgg gggcggatgc ggtgaagttg cgccgcagca gatcgggcac cgcctgggcg
     5941 gcggggtcag ggatggtggt gcggtgtcgc cgcttcaacc ttcggccctg gatagcatgt
     6001 tggcgcatga gccgctcgat gcgcttgcgg ttcaccatca caccgcccgc gcggagctcg
     6061 gcggtgattc gcttggcccc atacgtcttc ccggatcctg cgtggacctt gcgtatccgc
     6121 tgggtgagcg cggcgtcggc ggccttcttc gcggcgcgcg ccggggcggt cttcagccac
     6181 cggtagaccc cggaccggga caggttcagc acggtgcaca gccgcttcac gccgaaggcg
     6241 ccgcggtggt cggcgacgaa ctcgaagcgg ctcaccagtt cgtctcgccc gcaaaatact
     6301 tggccgcccg gcgcaggatg tcacgttcca tctccagctc gcggacctgc ttgcgcaagg
     6361 cagtgaactc cgcgtccttc gtggactgcg agactgactc gggccactcg gcgttctccg
     6421 cggtcttgaa ccactgccgc agggtctcgt ggttcacgcc gagctcggcg gcgatgcgtg
     6481 agacaggccg gcccgacgaa cgagccagcg ccaccgcgtc ggcccggaac tccgccgagt
     6541 acttgtaggt ccccacctgg gactcctctc cctggactca agatccagtg tcgaggtgtc
     6601 cacgatcaag gtggagagcc ccggtggata gcccactccc gtacggctcg ggattgattt
     6661 ttgaccttga ctcggatgag cctctgaatg aagttctctc ttgatcgtgg acagcgggtg
     6721 gttacgctgc gggagtgagg tcttgggctg ccagggcccg gggctcgatc ggggtgacgt
     6781 ggccgtatgc cgggtgcttg cgcagtcggg tgcggttgta ttcgacctcg atgaaatcgt
     6841 gatcacgcgc ccctgagggc caagactccc cgactgcacc tgcgcctgcc tgggcacagc
     6901 acgcccatca aagagccccc gatcaggagg accgtcatgt ctaagaaccc ctaacgaaat
     6961 gatcttcgag gaggttggct cactcgggga ctgatgaacc gggggtgcgg ggtggcgcgg
     7021 ccgaagccgt gggaagtcga cgacgcgcta tgggcggtga tcgagccgct gctgcccaag
     7081 gtcgagcgtc ggacccggca cccgggacgc aagcggcatc cagaccggct ggtcttccag
     7141 ggcatcttgt ttgtcctgca taccgggatc tcctgggagc atctaccgca ggaacttggc
     7201 ttcggctcgg gcatgacctg ctggcgccgc ctggccgagt ggtccaaggc caaggtgtgg
     7261 ccccggctgc acgaggtcct cctcgccaag ctccgcagcg cgaacgccct ggacttctcc
     7321 cgagcggccg tcgacggctc ccacatccgg gcgttgaagg ggggttccaa gacgggccga
     7381 agcccagttg accgtggcag aaccggcagc aagcaccacc tgatcaccga cgccaccgga
     7441 atcccgctcg ccgccaccct gaccggtggc aaccgcaacg atgtcaccca gctcatcccg
     7501 ttgctcgaag cggtgccgcc ggtgcggggc aagcgaggcc ggcctcggcg caggccggac
     7561 gtggtgttgg gccaccgcgg ctacgatcac gacaagtacc gccgcatggt tagggatctc
     7621 ggtgtgaagc cgctgatcgc ctgccgcggc accgagcacg gctccggtct gggcactcaa
     7681 cgctgggtcg tggagcgcgc gttcgcccac ctgcactggt tccgccgcct gcggatccgc
     7741 tgggagatcc gcgacgacat tcacgaagcc ttcctcaccc tggggtgtgc actcatctgc
     7801 tggcgacgtc tgcgctcatg ctgttgacct ctctagcaag ttgaacgagc ggactgcggg
     7861 tcgggagcgc atgctgcttc ctgggcggcc ataacctcat cgccgtgctc gaaggcccat
     7921 gcgccgacgg cgtcgatggg cgccaacaag gtccgtccca gagcggtgag ctggtactcg
     7981 acccgtgatg atgcatcggg gtgtgcctgc cgatcgacca gtccgttgaa ctgcagccgc
     8041 cgcagagtct cggtgaggac cttggagctg atgcccccga tccgctcccg cagttcgact
     8101 gggcgcctgg ggccgtcgcg cagcgcccag agcaccacgg cgttccaggt gttggagagc
     8161 aggtcgaagg cgaggcgggc gcggcagtcg gcgaggaagg cgtcggtcgt cacgtaccaa
     8221 atggtgcccg aacggccttc tagcgtcggt acgaaccgtc aaagcaggca cggagaggga
     8281 acgcgtgatg agaatcggcg tactgggaac gggcaacatg gctgacgcgc tcgccaccca
     8341 ctgggtgcgg gccgggcacg aggtgatcat cgggggacgg gacgcacaca aggcggagcg
     8401 gctcgcgacg cgcatcggag ggagcgtgaa gcctgccagt ctgtgcgtgg cggccgagtc
     8461 cggtgaggtg gtactggccg cgttgccctt cggggcggga gtagacgtgg cacgggacct
     8521 gcacgcagcc ctggagggca aggtgctgct cgactgctcc aacccggtcg ggccgggctt
     8581 ccggctgctg acggaaggag gcccctcagc cgcgcagcaa cttgccgcgg cggcaccggg
     8641 agcccacgtg gtcaaggctt tcaacctctg ccacgaggac gtgtggcgca tgcggccgcc
     8701 cgtcttcgac gggcgaccac tggccgtgcc catctgcggg gacgacgaga cggccgtcgc
     8761 gcgtgtacgc gagttggtgc aggacgtggg ctgcaaaccc gttgctggag gcggtctcga
     8821 acgggcagga ctcctggaag caaccgccgc gctgttcatc gccctgtggg taggcgaagg
     8881 ggcggatgcg caagcaatcg cgcctccgct ggcatacgcg gccggaccga gccaccagga
     8941 aacggaaggc ggcacgaggg ctttccgtta ggggttctaa ggacacccgg tccaacgcgg
     9001 ttacctggtg gccacccatg tcgtggacct tggtcaggtc gcgggcagcg gctgccgggt
     9061 gatggcccgg gtggcccagc ggggggtgcg acgggatcat gtgcggctcc tcatccgtag
     9121 ttccttaccg tcggtttctg ctcgccggct ccgcgctgcc gacccgtcgc cgtcggctcg
     9181 gcgtcgtcgg ttccgcggac gtcggccctg tccgcaccgg ctccgtcggc cacggtgcgc
     9241 ccgcccgtgg ccgggggcgg gacgtggagg tggcgggccg cgacggcgcc gccgacgagg
     9301 gcgaggagca ccaccagcga cgcggccccc agcacggtcg ggaagagccc gaaggcgtgg
     9361 gtgcacacgg ccgcgagggt ggggcccagc ggggagacgg cctgggcgag gaaaccggtc
     9421 ccgctgttca cccgcccctg gagctcagcc ggtgtcatcc ggatctgcgc ggtcgccagc
     9481 aggacggtga ccaccggccc acaagcggag gcgagagcga gcaggaacgc ggcagccccg
     9541 ctgtcgtgga cggttgcaaa gcccaccagc gccacagcgg ccacaccggt ggacagggcg
     9601 atgccacgcg ccgctgggaa acgccgggcc accggagtgg cgatcaggga gcccccagag
     9661 ccccggctcc gatcgctgcg gtctgcgccc cgatgcccag accggcctgc gccccgccgt
     9721 cggccgaggc gatgacgacg atcctcttac ctggccacac tactcagagt ggccaaaccg
     9781 cggcgaatcc tttccttgac gccctcttga gccagggcgc gttcaggtca cgcgtccagg
     9841 gagtgccctt gggtgtgagt gatcagcgtg gctcgaaagt tcgtttcgtc cgcatggatc
     9901 atgcctggtg ctggttccgt gagcggagcg ccgacaggga agctgctgcc ggagccggcg
     9961 gacgcgagga ccgggcaagg gcagggcggg gcccagtgcc tcagctcatg aggaacgccg
    10021 cgtcccagcc ggtggtgtcc tctggcgcgg tgccgcggcg ggcgtcggcg tagtcggcca
    10081 gggcgagggc gatgccggcg gcgccgtcca gcagccccgg gtggtgaacc cggtgcggtg
    10141 cgggccgcga cgtgccggag gggggcagaa cctggcgata gccgaaggga gttcgggcat
    10201 cgaagtccgc cacgagttcc cgggcgaggg cgtccgccgc cgcccacaac tccgtcgacc
    10261 cgccggcggc ggccatccga ccgacgatgt gcaggatgcc cgcgcggccg tggcagaagc
    10321 ccggatcgac ggcggtgacc gcgtcccgcg ggcggtgcac gaggccgcgg accgcgtccc
    10381 gggccagggc cgtcaaccgg tggtcgtcga gcgcctgccc ggccagttgc agggtccagg
    10441 cgatcccgga tgtcccgtaa caccatcccg gtgagctgct cccgccggct gtcccggacg
    10501 gccggcgtcg cgggggcggc ggggaaggct ccccgggcgc cttcgagtag gcggcgacgc
    10561 ggccgggcca ctggctgccg cggtcgtcgg cacggcccac gcccagcacc cagtcggcca
    10621 tgcggcgcag ggcgtcccgc atgcccggca cccggtgtcc ggcgcggtac gccagcgaca
    10681 tcagcgcgag cggaccgcag atcccgtggg cgacgccgac gttgaggtcg cctctgggga
    10741 actccgcgcg atcgcgcgcg aggagatagc ggtcgggcgc gcaccaccac cccggcacct
    10801 ggctcccgtc gccttccgcg gggcgcacgg ggtgcgtcat cccgaccagg aagcccagga
    10861 cgtcgtcgag cacctgcgcg caccgctcgt cgccgtcgtc ggctgccgcc aacaggccgc
    10921 gtgcctgtcc cgccaggccc gagatcacgt cgtagtcgcc gtacgccagc cccgggccgt
    10981 gctcctgccg ccgcgtcacg agccgggcga cgcgggcccc gacgtatgcg gcgtgcacct
    11041 cggcggagcg cgccagcagc cgggtgtacc cgccgtgggc gtgcgcgtgg agccgtgccg
    11101 gcagcagcag atcaccgacc gcggccgggc cggcgtcggt ggtcgccgcc acggcggccg
    11161 cgagatgggc gtgcccgatc gccgcgtacc gtgcgtcgtc ccgggcgcac cgggtgtgca
    11221 gcagcgcgat gccggggtgc cccagcagca gcgatgcggg ctgccaggcg ggcggcggca
    11281 cgtcggacgg cagcgcggcg aacgcgccac gggcggcgcc ggccacccgt tccggcgagc
    11341 tcagcagctc ggcgacgcgg tgggcggtgt ccgacgccgc gtcgcacagg gcgcggggtg
    11401 cggtcatccg gtgttcctgt tccgcttccg ggcgagccac agcgccagcg cctcacgggc
    11461 cgtcacctgc gcggtcagtt cctgttcggg accgggaccg agcagccggt tgacgtgcat
    11521 atgggtcagg ctcagggcga tccgtgcccg ccgcccgggg tccggcgcgc cggcggacag
    11581 cgcctcgcgc agatcggaca gcgccgcggc gcgggcgctc caccccgcgt ccccgccgtc
    11641 cgtcgcggcc ggcggccggg gcctggcccg ggagtccagc agagcggcga cggcctgttt
    11701 ccgctcccgc gggatgtccc cccggcgcgc cagcaccgcc gggctgctga gccagccgag
    11761 cgcctcgtcc ggggagccga ggcgggtgac gatgtcgagt atgcccggcg cggccttcgg
    11821 ggtcggatcg tccggccggg cggcggaccc ggccagcaga gcgacgaccg cctcgctgtc
    11881 ggcgtggaag aagcgctcgg catgggtgag ggcggccggt cccccgtacc gttcgacctc
    11941 gggctcgtag gtgtccagga ccaccttccc gaggaccccc gcctcctcgc gcgcccgcgc
    12001 ccaggcatgg agttcgggca gcagcaccgg ccacagggac tccggcgtgc cgtggaagcg
    12061 cagccggatg tgcggggccg gatcctcgta gcggacgaag aaccagcggt cgacgccggc
    12121 cctgcgcagc agcccgggat cggtcaacgg cccgaggtgg cgggccagca cctccggttg
    12181 gcgggcccgc ggcacatgga tcttcgcgta gagccactcg ccaccgggcg gatgggcacg
    12241 cgctccgcag cccgcggcgg cgtcgcccga acggagcggg accggcgccg ccacgggtcc
    12301 ggccggccgg gtcccgcgcg cggtgtccgg gccggtgggc ctggcgcgga cgccggtggg
    12361 cctggcgaag acggggaaga agaactcggc ggcatgggcg ccctcggggc cccggaacca
    12421 ctgccgttcc gccggccccg cgaatcgctc caccaccgtc aacccgggcg cccgccgcac
    12481 ctcgtcgcgg aacaccagga ggtgcagcgg gtcgtcgaga tcgaccgcca cgcggtggtc
    12541 ggccttggtg agcagcacct gccgggggac gtcccagcgc cgccgccacc gcccgacctg
    12601 tccgctccac tcctggtccc cgcggtcggc cgcggcacgc agcgcgcggt ccggcagcca
    12661 gcgcgccggg gagagcacgg tccggccgtg gcgcacccgc ggcagcgcgg gcgccgctgc
    12721 ccagcctccc cagctccacg gcgcgcagaa ggaccgcccc tcctgcccga tctccagcag
    12781 gaaccgtgcc acgtacggaa gatggcggcc gctggggttg agcatcgagt acgacagcgg
    12841 ccggaccctg cggccggtca cggtgtcgac gagccggagg ccgtcggtgt ccgcgcagac
    12901 caccaggtgc tccacacgca gatcgtgtgc cgtctccgcc gcggcgggtc cgacccccaa
    12961 cgggatgcga tgggacagcc attgggggac ggcggacaca ttggcggacc gcatcaccct
    13021 gggccggaag gcgacacagg cggggatctc gtcctgcggt gcgctccgct cggtgcgcag
    13081 cgccagctcc cggacctgtg cggccgaccg accgagcacc ggcgcgaacc ggctgaaggt
    13141 cgccccggcc agcggggaga ccgcatcggg cgcgagcacc agatggaagt ccccgccgca
    13201 cagggcgtcc cagcccggtg tcaccagctc ggctcccacc tccatgctcg gcggggcggc
    13261 cccccgctcc gccggctcca gggcgcgtac ggtctcctcg tcgagcacca cttcccggcc
    13321 gccgccgcgg gccgcggcca tcagcagctc gccgagcacc aggtcgcgcg tgccggcccc
    13381 ggcggcgggc ggtgacgcag ggggccgacg gtagtcgcgg ggcagcccca gcccgcggac
    13441 ctcgtcgagc agttcgagga ccggcaccga ccgttcggtg ccgtaccgct ccaggaagtc
    13501 caggtgatag tcgcgcaggt gcggattgcc tcggtggacg ggagaggtcc gccacaacac
    13561 cgtcgcggcc cgttccgctt cccgggccac ttcctgcggc agggtcagcc gcaccgtcgg
    13621 cgccaggtcc gtctggagga cgtccgcggc gggccgcatc gcccgcatcc gctcaccgac
    13681 cgcggtcagc cgggcgcgcc ggccgtccgg cggcgcggcg tccagggaac gcaactcggc
    13741 ccgaagggcg tgcagttcgt gggccgtggg gtggtcgact ccccgcagcc ggtcgcatac
    13801 gtggtcgagg ggggcggtgc agtcgggcgg cggggtcagg tcgccgagca ggaagtggcc
    13861 gcggacgagt tgccggatgc tgccttcgat cgcgccccgt ggcgcgtgcg ggaactcccg
    13921 cccggccgcc gccaccagcc ggggatgggg cgtggggtgc gccgcggccg ccaggagctg
    13981 ccggaccacc ctggtgtggc gcaccgaccc ggccaactgc cgctcgccgt cgcggtcgtg
    14041 gtggtcgacc agcaccagcc ggccgtcccg tacgacatgc aggttgttgg cggtgagccg
    14101 cgaacgctcc agcacggcgg ggacatcgag cagcgtctcc agaacgccgt ccagccaggc
    14161 cgcgtccggc cgggtcaccc ggcgcccgcc gccgatcggc tcccgcgcgg gcgcggggcc
    14221 gaacgcggcg aggccgaccc ccgcgaagag gccgaaaggc gtgggtcggt gggacatccg
    14281 cgagtggtac ttggtcagcg agagcgcgat ccggcgcagg gacctgagcc tgagccgctc
    14341 cccggcgacg gcacggtcga cctccgccgc caggcccgcg ctggccaggg acaccgcctc
    14401 catgagccgt gggtcggcgg cgagttcggc tatccgccgg cgcagccggt cctcgtcgta
    14461 cggggccgcg tcggacggcc gcgaccgccc cccagggccg tcctccgggg gcagcgggag
    14521 ggccgcggcg cgcaccagaa ccaccgtccc gcatgcgaaa tcaacgtcac ccgtaccacc
    14581 cacgccggcc ccgccccgat ccccgtacgc tccttcacct ggcaagggtg cggggtggtg
    14641 gggacgacgt cccgggcacc accccgcacc cgtggctcgg cggccgttac cagccgcagc
    14701 gccaggacgt ggacggacac acctgcgtca tgagcttcga ctcctgggcg tccccggcga
    14761 ccgtggccga atccatgatg tccacatcca ggtcgaggtc gaattcgtcc atgctgatgg
    14821 tggcgttctc catggcccct ccaaagaaag ctgtttaatt ccggagcaat tccggtggta
    14881 cgaacagatt tcgcaaccgt cgaggtattc catccgaggc cacagaccac gtcaagcgca
    14941 tttgtcgaag gcggcgttgg gccgccttcg acgcgcgccc cggcgttcgc cggcgagcac
    15001 ttgctcggtc gaacgcccat cacggggaaa cgggggccgt ccgcccgccg ctcgggggat
    15061 ggttcggcgg gcggacccgg ccggcgggcg cccgaccgcc ggcttcggcc cccgtactag
    15121 gagtcaactc ctttcccgcc gttgatgaca gcgtgtgaat gcgccatctc cgtgcgcctg
    15181 gttcgcaccc cgtgcgaaac gctcacgctg cgtcacttcg cacggggtgt gaaccgctga
    15241 cccggatccg cccgccgcac acgctcccgc cttccctccc tgggcagttg actggttcgg
    15301 gtaaccaccc gaccgtcact cggagaagga aagaggagcg gaacgtgacc gcccatcggg
    15361 accccgatac gatcgccgcc gacttagcgg agctgcgacg cctactcgac gtacgcaccg
    15421 ccaccgtcga cggtcagctc aggctgcagg cccaacgctg cgagcagaac accagggacg
    15481 cggacgaact ccaggcccgc atcacgcggt tggagagccg ccgctggccg ctgccctcgc
    15541 tcgccgcact cgccgggctc gccgcggggg cagccgccct gtggcaggcg tacgggcgct
    15601 gaggccggcc ggcctcagcc gagccggatg tggtgcagca tcagcagcgc cgcggccatg
    15661 ttcgcggccg gcacctcccc cctcgcgacc atgtcgggca ccagcttgag gtcgatccac
    15721 tcccgccggt ccgattcgaa gtcgtcctgc ggcgcgccga ggtactccgc ccggtcggac
    15781 cagtagatgt ggtgccgcgc gtcggtgagg ccgttggacg gctccaccga gaggaggtgt
    15841 tggaggggtc cgggtcgcca cccggtctcc tcctccatct cccgcgcggc cgcggcgacc
    15901 gggtcctccc cgtcctccac cacgccggcg gccagttccc agccccagct gtcggtgatg
    15961 aaccggtgcc gccacagcag cagcacctca ttggcctcgt tgaccgcggt ggccaccgcc
    16021 accggccgca tccggatcag gaagtgatcc aggtgacggc cgtcggggag ttccacatcg
    16081 gccagattga cccggaacca gggattcgcg tagaccggct tttcgctgag attgttccaa
    16141 cgcacgtaac tgccaccttc cgcttgaggg ccggcaaggt gacacgagcc cggtcacagc
    16201 ggaacgcgca gcacctcgtc gatgagatcg gcagcctcgt ccgtcgcggc actcccggtc
    16261 tccgccagat gctcgcgcac cgcccgcagc cggtcccgca ggcgttgcga ctccatgccc
    16321 cgagcctgct ccgtcatctc cgcggcgttg gccacggccc ggtccgcatc cccttggcgc
    16381 agctcgatat gggtgagcat ggccagccgg tgaacccggc cgcggtcgtg tgcgggggtg
    16441 tccacggcgg cgtccgcctg ctcccgggcg gaccgtaggt ccccgaggct gagcagcgcc
    16501 tccgccactt gtacgttcac caggcccggc tgcacatagc ccgtctcggc gggctccaac
    16561 cccgggcgga tccgctccgc cgcggcctcg gcccgccgga tgcagtccag cgcgcccgcg
    16621 ccgtcgccca gccgggcata cgccttggcc tgcatggcgt agaggtcggc cgagagcgcc
    16681 ggggtgagct gcccgccgga ggtgcgcagg gccgcctccg cgaaggcgac cgcctggcgg
    16741 tactcccgta cgaagaggga ctggttgacc aacagcgcga tcacatacgc gccgagtccg
    16801 cggtccccgc tggccttggc cagccgcagc gcctgatgga agtagcgctg ggccagcccg
    16861 agagcgtccg agtcgtacgc acagatgccc gcgacggcca ccagcccacc ggtcgcccgg
    16921 tgcagctgac gccccgtcgc gtcgctgtag ctgccccgca gcagcggcgc cgcctcggtg
    16981 ttgaggaatc cgacgatgcg cgctctggta gcgataccac ccgccttccg gtacatctgc
    17041 tcgtagtggg tccgcgcgac ccgcagcatc tcgatgtcgg ccatcccgac ccgggtcacc
    17101 ccgtcgcgcg agacgtcgaa gtcctccggc gggttctccc actcccacac cgggatgatc
    17161 gccgaggtcc cggtgagcgc gggcgccgcg accacgtgcg gccgctgctg ctcgtcggac
    17221 cgccacagcg cggtggcccg ctcgacgaac ccggacagcg gggtgcccgg ggcctggcgc
    17281 gcccccggcc cgctgagccc gatgtcggcc aggcccaccg gccggtgcag ccgctcgccg
    17341 aggatctcgc agatcaggtc ggggacctgc ccgcgcggcc gctgcccctt gagccagcgc
    17401 gccacggccg tgtgctcgta gcgcagcgcg agcccgcgcc gccgcccgag gtggttgatc
    17461 cgcgtcgcga gcccggcgtg cgagataccg gcctcgtcca ggatcgcgtc gagcagcgtg
    17521 ttgggctcca tgcctcgccc ccaaggacgt acggactccg taagtccagc gtaatcaggg
    17581 ggagttcaca ccccgtgcga aacggcgccg aaccggccgg cggcgtccgc ccgcacaaca
    17641 cgacgggccc ccgcccacca gcgtggacgg gggcccgtac gaggcacggg ggccgcgggg
    17701 cgtcagccgc gcagggccgc gcccacccgc tcgaccgcga cggcgaccgc cgcgtcccgg
    17761 gccgcggtgg cctcctcggc ggtcagcgtc cggtcgtccg cccggaaccg cagcgcgtag
    17821 gccagcgact tcctgccgtc gcccacctgc tcaccggtga agacgtcgaa cagccgcacc
    17881 gactccagca gttcgccggc gccgtcccgc agggcggtct cgacgtccgc cgccgccacc
    17941 gacgcgtcga cgatcagcgc gacgtcctgc gtggcgaccg ggaaggtgga gatccgcggc
    18001 gcctgcagcg aaccggccgc ggcccgctcc agccggtcca ggtcgatctc catcgcgctg
    18061 gtgcgctccg gcagaccgag ggtcttgacg acccgagggt gcagctcacc ggcgttgccg
    18121 acgagcacct cctcaccgtc gaccagggcg agcagcgccg cgcaccggcc ggggtgccac
    18181 ggggcgtgct ggtcctgacg gacgatcagc tcgacgcccg cctcccgggc gacggcccga
    18241 ccggcctcga cggcgtcggc ccacccggac gggtacccgg caccccacca gccggcctgc
    18301 tcgcgggcgc cggccaggac caccgcggcc cggcgcggct gctgcggcag cgaggcgtcc
    18361 agcgcggcga tctcgtcgtc ggtcggccgg cggtcgacca ccagccggcg ggccggcagc
    18421 tccgtgccgg tcgcccggaa caccggaccg gtctcgaaga gcgccaggtc gtggttgccc
    18481 cgcccgtagt tgcggcgcag cgaggccagc agccccggga tcagcgtcgt gcggaggtcc
    18541 ggctcctcgt ccgagagcgg gttcaccagg gtgaccgcgt cccgtcgcgg gtcgtccggc
    18601 tcgatgccga gctggtcgag cacggccggg ccggtgaacg ggtagttcag cgtctcgacg
    18661 tatccggcgc cggccagcgc gcggccgacc cggcggtgca gtcgctgacg ctcggtcagc
    18721 ccacggccgg cgggcggcag cggcagcgtg gagggcaggt tctcgtagcc ctccagccgg
    18781 atgacctcct cggccaggtc gttcgggtcg ccgaggtcgg gccgccagga cggcacggtg
    18841 accaccagct cgtccttccc gcccgtctcc cgaccaccgc cccccaacgg cgcgttccac
    18901 gcggcagaat ttccgtagac gtcgcagccg acctgctgga ggcggcgcac gacggtctcc
    18961 cgcccgtacg tcacaccggc gaccttgtcc gggtggtccg ccgggatggt gatcgtccgc
    19021 ggcccgcgcg gcgagacgac ctcggtgacg ccctcctcgg cggtgccgcc ggcgagcagc
    19081 accagcaggt ccacggtccg ctgggccgcc gcggacgccg cctccgggtc caccccgcgc
    19141 tcgaagcgct tggcggcctc ggaggacagc cggtggcggc gggcggtccg ggcgatggag
    19201 atcgcgtcga agtgcgcggc ctcgatcacc acgtcggtgg tgccgtgcac ccgcccggtc
    19261 tcggggtcgg cgaccggcgc ggcgatctcc gtgttggcgc cgcccatcac gccggccagc
    19321 ccgatcgggc cgcggttgtc ggtgatgacc aggtcctcgc cgtccagcac ccgcttggtg
    19381 ccgtccaggg tgaccagttc ctcgccgggc gtggcgcggc ggacgccgat cggaccctcg
    19441 acggtcgtcc ggtcgtaggc gtgcaacggc tggccgagct ccagcatcac gtagttggtg
    19501 atgtccacgg cgagcgacac cggccgcatc ccggccttct gcagccggcg ctgcatccag
    19561 atcggggtgc gggcctccgg gtccagaccg gtcaccgtac gcgcggtgaa gcggtcgcag
    19621 ccgatcgggt cgccgacctg gaccgggtag ccaccggcgt tcggcggcgc cacgtccagc
    19681 agcgccgggt cgcgcagcgg cagcccgaac gcgatggccg cctcacgggc cacgccgcgc
    19741 atcgacaggc agtagccgcg gtccggggtg acggcgatgt ccagcacctc gtcgcggagc
    19801 tccagcagct cgatcgcgtc gatgccgacc tcggtcgccg gcggcagcac gatgatgccg
    19861 ccggagccgt cgtcgcccat gcccagctcg tcgccggagc agatcatgcc gtgcgacttc
    19921 ttgccgtagg tcttgcgagc ggcgatcttg aagtcgccgg gcagcaccgc gccgggcagc
    19981 accacgacga ccttgtcgcc gaccgcgaag ttccgcgcgc cgcagacgat ctcctgcggc
    20041 tcaccggtgc cgttggcctg gccgacgtcc accgtgcaga agcggatcgg cttcttgaag
    20101 ccctccagct cctcgatggt cagcacctgg ccgacgacca gcgggccgct caggccctcg
    20161 ccgagctgct cgacggtctc gacctccagg ccgaccgcga tgagcttctc ctgtacgtcg
    20221 cgcccggtcg tcgtcgccgg caggtcgacg tactcccgca gccaagaaag cgggacccgc
    20281 atcagatctc catcccgaac ggccgggtga accggacgtc gccctcgaac atgtcgcgca
    20341 tgtcttccac gttgtgccgg aacatcagca tccggtcgat tccgaacccg aaggcgaagc
    20401 cgctgtactt ctcggggtcg acaccgcagg cgatgagcac cttggggttg accatgccgc
    20461 agccgcccag ctcgatccag ccttcgctgg agcaggtacg gcacggccgg tcggggttgc
    20521 ccacggactc gccacggcac acgtagcaga ccatgtccat ctcggcggac ggctcggtga
    20581 acgggaagta gttgggccgc agccgggtct tcatgtccgg accgaacagc gcccggacca
    20641 tgtggtccag ggtgcccttc aggtccgcca tggtcaggcc ctcgtcgacg gccagcagct
    20701 cgatctggtg gaagaccggg gagtgcgtgg cgtccagctc gtcggtgcgg tagacccgcc
    20761 ccgggcagac gacgtagacc ggcggctcgc ggtcgaccag cgtgcgggcc tgcaccggcg
    20821 aggtgtgggt gcgcagcacc acgcccgact cgtcgccctg ggtgccgttg ccctggacga
    20881 agaaggtgtc ctgcatctgc cgcgccgggt ggtccggcac gaagttcagg gcgtcgaagt
    20941 tgaaccactc ggcctcgacc tcggggccct cggcgatctc gtagcccatc gccacgaaga
    21001 cgtccgcgac ccgctccatg aaggtggtca gcgggtgccg ggcgccggcc gcgacccggt
    21061 cgtacggcag ggtgacgtcc accgcctcct cgaccaggac gcgcgcgtca cgctccgcct
    21121 ccagctcttc ctggcgggcc ttgagcgcct ggttgacccg gccgcgggcc tggccgacgc
    21181 gcttgccggc gtccgccttg gcctgcgggg gagggcgccg atctcgcggt tggcgagggc
    21241 gagcggcgat gtgccaccgg cgtgcgcgat cttcgcctgg gcgagcgcgt cgaggtcccc
    21301 cgcggcggcg atggcggcca gcgcctcgtc gacccgtcgg gcgatctctt ccggtttcag
    21361 ggcttcgacc tcgacagggt cgtacgactt attgggtgcg gacatctctt cccgtgcttc
    21421 cggtggtgtg gcttggcgcg gctcgcttcg cctcggctct gcgcccgcgt gtccgcgatg
    21481 cctgtgcgcc aaaggtgcca aaggtcaagt ctaaggggcg ggccctcccg gacccgccgt
    21541 cggccctgtc cgggccgtcg cgcggcgccc gccgcccgcc cgtcgcccgg ccaccgcccc
    21601 tgttcgacgc ttcgcggccc cccttcacgc caggaaggca ggggccgcga cgggcaggct
    21661 aaatcggaac tgggcgccgc cggccggggc ccggccgacc gtgatcgtgc cgccgtgcgc
    21721 ctcgacgatg cccttgacga tgtacaggcc cagcccggtg ccgccgcgct tgctgccccg
    21781 ccagaaacgg gtgaacacgc ggctcatcga ctcctcgggg atgccggggc cctcgtcgct
    21841 cacggtgacg ctcgtcccct ctccgccgcc ggtctcctcc gccggtccca cctcgatggt
    21901 gaccgttccc tcgccgtgac gcacggcgtt ttccaggaga ttgcccagga cctggtccac
    21961 cttgtccggg tctgcccaca gatcgggcag cggctccatc atccggatca ggaagcggtc
    22021 cggcagctgg cccgcggtgg tctgcgcctg cacgtgccgc cggaccgcgg cgatcatgtc
    22081 cacccgctgc cggcggacct ccagccgccc ggagtcgatc cgggagatgt ccagcagctc
    22141 ggcgatgagc cgggtgacgc ggttggcgtc ggcgtccacc gtctccagca tcagccgctt
    22201 ctggtcgtcg gtgaaccgtt cccacttctg gaggagggtg gcggtgaagc ccttgacgga
    22261 ggtcagcggc gaacgcagct cgtgggcgac ggtggcgatc agctcggcgt ggctcagctc
    22321 ggtgcgccgc ctggcctcgg tgccgcgcag cgcgatcacc agccgccgca ccgggccggt
    22381 gggccgactg cggacgtaac gggccgagac cagcacctcg cggccgccca gcagcaggtt
    22441 ccgctccggc tggccgcggc ggatggccag tcccccgtac gggtcggtca actgccacca
    22501 gcggcgcccc tcgatgtcct gcagcggcag ggcgtccccg accggccggc ccagcgcctg
    22561 cggcggctcg atgccggtga tccgggcggc ggcggcgttg aagcagatca cccggccgtg
    22621 ttcgtcggcg acgaccagcc cgtcggggag gtcgtccggg gccagcccga gatccgcgcc
    22681 ggactcctcg ggcgggcagc caccagcggt ggcagtactg gccgaagtcc tcgccgtcat
    22741 cgccgtgtta ccccctcccg ggccggagct ggcaagagta ctagctcggc ccggccccac
    22801 cgccgggttc gcggctacgc ccctccggcg ggtgacgtcg cgcggcaccc tccggtggtg
    22861 cgctgggccc gcgcggaggc gtacaggcag accgcggcgg cggtcgcgag gttgaggctc
    22921 tcggccttgc cgtggatcgg cacccggacg acggcgtcgg cgagcgcccg ggtctcctcg
    22981 ggcagccccc acgcctcgtt gccgaagacc caggcggtcg gcccgcccat ggaaccggcg
    23041 tccagctccg cgtccaggtc gcggtcgccg gccccgtcgg cggccaggat ccgcaccccg
    23101 gcgccctgca gcccggtcac cacctgctcc accggcacgc ccaccgcgac cggcaggtgg
    23161 aacagcgaac ccaccgacgc ccgcaccgac ttggggttgt agaggtccac ggacgcgtcg
    23221 gtcagcacca ccgcgtcggc gcccgcggcg tccgcgcagc gcagcaccgt gccggcgttg
    23281 ccggggtcgc gcacgttggc cagcacggcc accagccgcg ggcgggcggt gaggatctcc
    23341 tcgaacggcg agtccaggaa ccggcagacg cccaccagac cctgcggggt gacggtctgc
    23401 gagacgtccg cgacggtcct gtcgtcggcg aagtgcacca gcgcccccgc cgcccgggcc
    23461 gcctcgacga tctcggcgtg ccgctcggcg gcctcgacgg tggcgaacag ctcgatgagg
    23521 gtgggcgatc cgccggcgcg gtgcgcgacg gcctcgcgga cggcctgcgg gccctcggcg
    23581 atgaaccggc gttccttgcc ccggaagtgc cgccgggcca gccgccgggc ggcggcgact
    23641 cgcggggaac gcggggagat cagctcgggg gtgcccatgg gcggcggctc gcttctttcg
    23701 ttcggtgcgg gggcccggtg cggacgatgg ggtctccccc gctcgaacgg ggccgagagc
    23761 ggggggacgg gcccgggaaa cccggaaacg cggcggaccc gcaggccggg gcccgcgggt
    23821 ccgcaatcac aacgtcgtca catcgtcacg acgccgtcgg cgtcaggccg cgattcaggc
    23881 agcagccttc ggggcgttga cgtcgctcgg cagcgccttc tgcgcgacct cgaccagcgc
    23941 ggcgaacgca ccggcgtcgt tcacggcgag gtcggcgagg atcttgcggt ccacctcgat
    24001 gctggcggcc ttcagaccct ggatgaagcg gttgtaggtc atgccgttgg cgcgggcagc
    24061 ggcgttgatg cgctggatcc acagctgacg gaagtcgccc ttgcgcttct tgcggtcgtt
    24121 gtagttgtag acgaaggagt gggtgacctg ctccttggcc ttgcggtaca ggcgggagcg
    24181 ctggccacgg tagccgctgg cctgctccag gatcgcccgg cgcttcttgt gggcgttgac
    24241 tgcccgcttg acgcgtgcca cttgttaact ccttgtagcg gggccgtggt tgttcgtcac
    24301 acggcccgaa tcgacgttag gtcccggtcg ggtcggtgcg ccccgcccgt gcggcggagc
    24361 gccccggctc acttgccgag aagcttcttg atcttcgcgg cgtcgcccgg ggccatctcg
    24421 gcgttgccgg tgaggcggcg cgtcacgcgg gacgacttgt gctcgagcag gtggcgcttg
    24481 ccggcgcgct cgcgcaggac cttgccggag ccggtgacct tgaagcgctt gctgg
//
