LOCUS       NZ_JAPTYM010000001     27232 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Streptomyces noursei strain ATCC 12757
            contig_1_pilon_pilon_pilon_pilon, whole genome shotgun sequence.
ACCESSION   NZ_JAPTYM010000001
VERSION     NZ_JAPTYM010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Cost-effective hybrid long-short read genome sequencing and assembly
            protocol for GC-rich Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10059690)
  AUTHORS   Koduru,L. and Wong,F.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2022) Institute of Molecular and Cell Biology,
            A*STAR, 61 Biopolis Dr, Proteos, Singapore 138673, Singapore
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-AUG-2022
            Assembly Method                   :: Flye v. 2.8; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_026913165.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 08:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,375
            CDSs (total)                      :: 9,278
            Genes (coding)                    :: 8,845
            CDSs (with protein)               :: 8,845
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 433
            CDSs (without protein)            :: 433
            Pseudo Genes (ambiguous residues) :: 0 of 433
            Pseudo Genes (frameshifted)       :: 168 of 433
            Pseudo Genes (incomplete)         :: 311 of 433
            Pseudo Genes (internal stop)      :: 17 of 433
            Pseudo Genes (multiple problems)  :: 60 of 433
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:08:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1727105
            Orig. end                         :: 1754337
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPTYM010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27232
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..27232
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27232
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:17232](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17232)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    4..17
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.57"
                     /tool="antismash"
     gene            complement(384..743)
                     /locus_tag="O1M07_RS07700"
                     /old_locus_tag="O1M07_07695"
     CDS             complement(384..743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714379.1"
                     /locus_tag="O1M07_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07695"
                     /product="hypothetical protein"
                     /protein_id="WP_189867649.1"
                     /transl_table=11
                     /translation="MSHNEQAGRWDGPWYRVRTEHFEAAFLPNAGEDLKSVDNIDVFVD
                     LNDGTRWSATVITLAQVETIMERWAATGEALGGAYFSCSDGLIVRDAGISKMTQVLVGL
                     VETGDFTHILQPIDE"
     gene            998..2536
                     /gene="istA"
                     /locus_tag="O1M07_RS07705"
                     /old_locus_tag="O1M07_07700"
     CDS             998..2536
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="istA"
                     /gene_functions="other (smcogs) SMCOG1213: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005476990.1"
                     /locus_tag="O1M07_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07700"
                     /product="IS21 family transposase"
                     /protein_id="WP_189868232.1"
                     /transl_table=11
                     /translation="MKNSREIMEILEAYDLTGSYRAAAELAGCDHHTVARYVKMRAAGQ
                     HPDQRRHRSRAIDDYLPKIEDLVVRSQGKIRADVVHKRIAAMGFTGGERTTRRTVAEAK
                     AQFRAGRRRVYRPWVTEPGLWLQYDFGDGPVIKGRKTTLFCAWLAWSRFRVVIPIWDKT
                     LPTVTACLDATFRRIGGIPAYVLTDNEKTVTTDHVAGIAIRNPEVVEVARHYGTTIRTC
                     LPADPETKGGSESTVKIAKADLVPRDVNLREEYRTFGELEAACRSFCEEVNSRIHKATR
                     RKPVERLAEEAQRLHPLPRSPFTAAFGTTRRVTWESTISVDAVRYSVPHELIDTRVWAR
                     FHGDELIVTAVDEHGSAIEVARHPRGEPGSPVLDDAHYPPREDKGTDRTPRATSAEEAA
                     FLQLGPGAASWLIEAGAAGVRRVKAKMAEAVALSKLYSAAEVDRALGTAAVTARFADKD
                     LLSILDYQAVHGMAEPVRRSEDHSLQPGTSAWSALGAPATSTPDLSEYDESDLA"
     gene            2536..3327
                     /gene="istB"
                     /locus_tag="O1M07_RS07710"
                     /old_locus_tag="O1M07_07705"
     CDS             2536..3327
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="istB"
                     /gene_functions="other (smcogs) SMCOG1151: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003944771.1"
                     /locus_tag="O1M07_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07705"
                     /product="IS21-like element helper ATPase IstB"
                     /protein_id="WP_189868233.1"
                     /transl_table=11
                     /translation="MATPLRTVPGTNGDPLAEAIELTKRLKLPHIRRSLTDIIPTAKAQ
                     RWDPAEVVRVLLAEEAAGRDRANLHTRRKRAGFPTGKTFGDWHEGKSSIPRPTQDALKS
                     LEWVGRRENFCICGPSGTGKSHFTEALGQTAVEAGLTVAWFTIEDLGALVRRHRADDSI
                     ARALAKIVRSDLIIVDDIGLLPVSEDAAEGFYRLVDAAYERRSIAVSSNLHPSGFDEIM
                     PKTLATATVDRLLHHAHVTVTQGDSFRFTEATTGKGVKPFS"
     gene            complement(3411..3734)
                     /locus_tag="O1M07_RS47715"
     CDS             complement(3411..3734)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040041.4"
                     /locus_tag="O1M07_RS47715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6262 family protein"
                     /protein_id="WP_372516455.1"
                     /transl_table=11
                     /translation="MRRLVKAGEEINFRAVARAAGVSLDFLYTHTDLRKRIETLCGQQR
                     ADHQALRQEPSADDGTVIHSLTEALRRERAVHRERIQELEQRLAAAHGEILRLLSTAVW
                     CSP"
     gene            complement(4066..4440)
                     /locus_tag="O1M07_RS07715"
                     /old_locus_tag="O1M07_07710"
     CDS             complement(4066..4440)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_07710"
                     /product="hypothetical protein"
                     /protein_id="WP_189862313.1"
                     /transl_table=11
                     /translation="MTRPMVGREALAEILYLGGNQLVLGPVSGERFRRLTLLVEEALSD
                     TDNRGGSSVLSLVSDLPPSPVPVRKVTRYIIEDGQCTEAAELNRRQYGACPATFARVEA
                     ARAADDARVLATLPGRCSVL"
     misc_feature    complement(4430..4446)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.23"
                     /tool="antismash"
     gene            complement(4606..5292)
                     /locus_tag="O1M07_RS07720"
                     /old_locus_tag="O1M07_07715"
     CDS             complement(4606..5292)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009311981.1"
                     /locus_tag="O1M07_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07715"
                     /product="DUF317 domain-containing protein"
                     /protein_id="WP_189862311.1"
                     /transl_table=11
                     /translation="MYWVTPRHLAGDDDALAEWIGDTLTGLGWRMWPTSRNTLVYVSPD
                     ELRGAEWILASYPFELGGLPVAWQLSARPHTDSAMTEWNAYFTAGVPHEALADLLLALD
                     TREAPDTGFASAESVLTALSARGWLRDMDRPRTTATDPGFSGHVSLEMLPPLIHDADPR
                     DDLLGWQAWAEPVLGAPYLWCASFSASVPHDLVAAFASSLASPVPVPRRTLPKIAQERL
                     TVVRRS"
     gene            complement(5371..5652)
                     /locus_tag="O1M07_RS07725"
                     /old_locus_tag="O1M07_07720"
     CDS             complement(5371..5652)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998502.1"
                     /locus_tag="O1M07_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07720"
                     /product="hypothetical protein"
                     /protein_id="WP_189862342.1"
                     /transl_table=11
                     /translation="MTVGELIDLLSACDRDAPARLAINPMFPMAYRLGNVIAATDEHGK
                     PVVFITEAKDAEQLGHLPPDVAVAVTWHEPTEAPPRRRRGATGPSAGQ"
     gene            complement(5765..6124)
                     /locus_tag="O1M07_RS07730"
                     /old_locus_tag="O1M07_07725"
     CDS             complement(5765..6124)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036834.1"
                     /locus_tag="O1M07_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07725"
                     /product="DUF317 domain-containing protein"
                     /protein_id="WP_189862309.1"
                     /transl_table=11
                     /translation="MPRTVDVASAGFATTVEALRLRSWELGPGQPTLVIDQFSAEDFSL
                     VVDDRADVHIGSKDGSFYLGWYPAGRPGTEGEGWRLTVSGTAKVPGYHISFGTETPAEI
                     VAATVAKVLATSRPL"
     gene            6617..6790
                     /locus_tag="O1M07_RS07735"
                     /old_locus_tag="O1M07_07730"
     CDS             6617..6790
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024407.5"
                     /locus_tag="O1M07_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07730"
                     /product="transposase domain-containing protein"
                     /protein_id="WP_372516254.1"
                     /transl_table=11
                     /translation="MPRPGQVKSSSGERLSDRIALGVLTRVFPPELVDEVIAECGRGEQ
                     RARLLRVCPVDG"
     gene            complement(6808..8098)
                     /locus_tag="O1M07_RS07740"
                     /old_locus_tag="O1M07_07735"
                     /pseudo=""
     CDS             complement(6808..8098)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958788.1"
                     /locus_tag="O1M07_RS07740"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="O1M07_07735"
                     /product="IS256 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDTTIEQIPGGEPAAEAVAASDEQLVAMLVDRARSEGLQLTGEG
                     GLLQQLTSGCWSPPWRARSPITSDTRSVMPRAVAAATAATGPGRRRC"
     gene            complement(8181..8351)
                     /locus_tag="O1M07_RS07745"
                     /old_locus_tag="O1M07_07740"
     CDS             complement(8181..8351)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1M07_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1M07_07740"
                     /product="hypothetical protein"
                     /protein_id="WP_189862307.1"
                     /transl_table=11
                     /translation="MVSLGNAVARIHQVLCEFALVGLRSGLSYTQMSAWTAIPEDGLAQ
                     QVEDYHRLMTT"
     gene            complement(8541..9899)
                     /locus_tag="O1M07_RS07750"
                     /old_locus_tag="O1M07_07745"
     CDS             complement(8541..9899)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560295.1"
                     /locus_tag="O1M07_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07745"
                     /product="cytochrome P450"
                     /protein_id="WP_229921845.1"
                     /sec_met_domain="p450 (E-value: 2.4e-81, bitscore: 272.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIARTIPRAPGSLPLLGHALSLRRHPLAFLVSLPAHGDVVRVKL
                     GPAAALVLCDPDLVQKVLLDDRTFDKGGPLIERGREGLGNGLATCPHGDHRRQRRLTQQ
                     AFQTQRMPAYAQMMSKQIAEAVGRWGDGDIVDVLTAMQTITARTTLATMFADTSDASLT
                     DLLADFNVFSRGVYKRMFMPPPLHKLPTPGNRRYHQARARLRQAIGSVIENHQARDDNS
                     GDLLSILLAASDDGQGLSDAEITDQVMSFLYAGIETTAAVLAWALHQLAQHPDLEARLH
                     TEVDAVMPKGAPATFDLLPQLQFTNRIITETLRLHPPGWMLTRIATTDTQLAGYPVEKG
                     TTIVYSPYLIHHQAALYPDPERFDPDRWNGRTTRGRNSALIPFGGGTRKCIGDTFGLTE
                     AALTLATITAQWRLEPTPGATVRPVPGLILNPHGLAMRITARTTSNPAAPRST"
     gene            complement(10001..10827)
                     /locus_tag="O1M07_RS47720"
                     /pseudo=""
     CDS             complement(10001..10827)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="O1M07_RS47720"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /pseudo=""
                     /sec_met_domain="T1TS (E-value: 0.00092, bitscore: 17.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNEVRLAQPEATENACQGSCTDREVHRRAPFALRSDPGRRRGGP
                     AHRTVVLRPSPRRGFPSQASSAACAPGWAVAATLQDLTAGRSAGFDRVPRSAISAWLWS
                     FYQSLVDQGSGRIPTVTAYRRQRAVAGAAYSLLDVVEIAAGIDLPETVRHFSSTPPAST
                     PAFTTTCGPWNSTQPPAPSTTRSSSSSTTTAFRSRMLSMPSTRCSQTASGVCRMPNET"
     gene            complement(10916..12271)
                     /locus_tag="O1M07_RS07765"
                     /old_locus_tag="O1M07_07760"
     CDS             complement(10916..12271)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237582.1"
                     /locus_tag="O1M07_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07760"
                     /product="cytochrome P450"
                     /protein_id="WP_189862302.1"
                     /sec_met_domain="p450 (E-value: 3.6e-81, bitscore: 272.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALKSIPAAPQGLPFVGHLVPLLRDPLVFLTSLPAHGDLVRIRL
                     GPFTLIVICHPELTRQALVDDRTFDKGGLLYDRAREVMGDGLGTCPHSEHRRLRRLAQP
                     AFHPARFPAYGQAMTACLDQVTGSWQTNQTLDVPTEMMSITCKVTAATLFSSALPPADL
                     SQLLNDIKTVFDGIYQRMFLIPPLDRAPTRNNRTYRDARTRLHDTLDGIVHQRRTDGSD
                     RGDLLSALVAAHDAEDAGSGMTDAEISDTIVTFFLAGTETTASAVAWALDLLARHPEIE
                     RRLHAEVDAVLQGAPATHADLPRLELTERIITETLRLRPPGWFFTRKTTGETRLGGHTL
                     PVGANVVYSPFIIHHRPDLYDNPETFDPDRWDRNRTQPLRHSFLPFATGARKCIGDTFA
                     MAQATLALATISARWRLEHISGRQVRPALGTVLRPRELHMQTRPRTATHTKP"
     misc_feature    complement(12212..12214)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12371..13267)
                     /locus_tag="O1M07_RS07770"
                     /old_locus_tag="O1M07_07765"
     CDS             complement(12371..13267)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="O1M07_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07765"
                     /product="terpene synthase family protein"
                     /protein_id="WP_189862300.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-12, bitscore: 45.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADLLVPYHRHMADDRHRELAKALLTWSLQLCSCNRGSAWHARE
                     AFYAATFERYCAPPDAAERENLLCAKYITFFFSLDDGLHNELEALADQLRSGRPVRAGE
                     LGTLHDALLADLRAHGLDTKQVEARIAELCAAAVTERARDARTMTQEQFHDLRMVTVAA
                     KPYIDCRRAVRNLPVPNEENLVEQALEAIYIANDLASLDKETASGGAGEYETSNIVRFH
                     AACSGRDLNAVITTVTDRYNHIAATLRNTTPGPLATILTSTVDGNLRAHVGLSTTRYPG
                     AARLLRCLQPVVPPSRR"
     gene            complement(13472..15025)
                     /locus_tag="O1M07_RS07775"
                     /old_locus_tag="O1M07_07770"
     CDS             complement(13472..15025)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.5"
                     /locus_tag="O1M07_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07770"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_189862298.1"
                     /sec_met_domain="T2TS (E-value: 6.6e-34, bitscore: 116.3,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVSAIDTIASALQRTVEYLLDTQDESGGWAMLPEPRILETALSL
                     HTLATLQPVGLVSNDVGAALSRARRWLTTAAPQEQHPVATVVEQTLRDIALDQAAYIDL
                     SHHTFTDAVYSSRQLLLYAVALSARRSVDAGPPPEDVRDQIGRRYANYARQNLKPWSTV
                     ELLAVRALIESFFGDEAAAAEAVGRIKSHQAVDGSFSQNPISTSMALLALHVSDPDGVA
                     VRQGCQWLLDAQQPDGTWRFCTCDVWDTTLVIRALGQHPLFRERALRPALEFLSGRQND
                     DGGWGFGGHSQSDSDTTGAALLALPTDTQDKEQIRQAIDYLARQQDGNGLWRTWQFDHD
                     PPAQDVVAHVLAGLDRFSEYHRVPLEPARHWLEAQYRSSVGGWRAGWYHNSPYAQLEVG
                     RALGFTHSLVQDAGRALAASQNSDGGWGRMAGEQSCASATGLAAAALARCQGDGSPTVV
                     AARAFLIRTQCGDGTWPGVPEMLGPRPLLTHMPIETQAFAVTGLSSVLSTNSHYQERQT
                     "
     gene            complement(15149..16147)
                     /locus_tag="O1M07_RS07780"
                     /old_locus_tag="O1M07_07775"
     CDS             complement(15149..16147)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469511.1"
                     /locus_tag="O1M07_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07775"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_189862296.1"
                     /transl_table=11
                     /translation="MSTAGQATPLPGDSGTKRVLLAVPRGFCAGVARAIQTVEKALELY
                     GAPVYVRHEIVHNKHVVQTLQRKGAVFVKEVDEVPEGATVIYSAHGVAPVVHDKAAERD
                     LVTIDATCPLVTKVHKEAVRYAREGYDILLIGHEGHEEVIGTLGEAPEHITLVDSPDDA
                     ANVEVRDESKVVWLSQTTLSVDETTETVNTLKEKLPHLISPPSDDICYATQNRQAAIKQ
                     IAQQAEMVIVVGSPNSSNSQRLVEVAKLAGACDAHLIDAASEINETWLDDVMTVGVTSG
                     ASVPDILVEQVLKWLARHGYQDVTTVTAAEEAQQFALPRELAPRRTRATQP"
     misc_feature    complement(15707..15709)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16144..17232)
                     /locus_tag="O1M07_RS07785"
                     /old_locus_tag="O1M07_07780"
     CDS             complement(16144..17232)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957287.1"
                     /locus_tag="O1M07_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07780"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189862295.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.9e-49, bitscore:
                     167.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTPLATAQPIDLPAARAQIDTVLTDFLNAKTDAAAASGLPRDL
                     AQAVRRHLQAGGKRLRPLLCVTGWHAADGHGDTIPLLRTAAAVEMFHAFCLIHDDIMDN
                     SEMRHGRPTVHRHLAADYGVGHSPEQARKLGADAALLVGDMALAWSDELLHTAGHPSTT
                     LAALHDVIDLMREEVIYGQYLDLTSTGQATGDIEQALQIILYKTAKYTVERPLHIGATL
                     AGADQHLLDALSAFALPLGEAFQLRDDLIGAFGNEATSGKSCLDDLREGKPTVLIAHAL
                     KAADDTQARLLRTLYGNPRLEEDSAATLRTVLKATRADQTVEHMIADRFEHAVTALYEA
                     PIPPHVQGQLRHLAENATWRTS"
     gene            complement(17229..18371)
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="O1M07_RS07790"
                     /old_locus_tag="O1M07_07785"
     CDS             complement(17229..18371)
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity (ferredoxin) [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009068955.1"
                     /locus_tag="O1M07_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07785"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_189862294.1"
                     /transl_table=11
                     /translation="MPAIDLGLPSPPPTTPVRRRTRRIHVGDVPVGGGAPVSVQTMTTT
                     NTADVDATLQQIAEITAAGCDIVRAAVPSQDDADALPDIVAKSKLPVIADIHFQPRYVF
                     TAIDAGCAAVRVNPGNIKKFDDRVGEIAKAAQAARVPIRIGVNAGSLDQRLLAKYGAAT
                     PQALVESALWECSLFEEHGFCDIKIAVKHHDPMTMVSANRLLAQQCDYPLHLGVTEAGP
                     AFQGSIKSAVAFSILLSEGIGDTIRASLSAHPVEQVKAGCHILQSLGLRPRQLEIVSCP
                     GCGRLQVDIHRLAAQVEAAFDGFPHPLRVAVMGCVVNGPGESREADLGVSCGNGKGQIF
                     RQGEVLRTVPESKIVNALLDEALRLTESVNEPVAEAGEHS"
     gene            complement(18373..19716)
                     /gene="dxr"
                     /locus_tag="O1M07_RS07795"
                     /old_locus_tag="O1M07_07790"
     CDS             complement(18373..19716)
                     /EC_number="1.1.1.267"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0030604 - 1-deoxy-D-xylulose-5-phosphate
                     reductoisomerase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dxr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602787.1"
                     /locus_tag="O1M07_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07790"
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /protein_id="WP_189862293.1"
                     /transl_table=11
                     /translation="MAPRTALPHPPGNSARPPLRRILETAGTPTAVGGDDGVRAVVVLG
                     STGSVGSQALDVITAYPGRFRAVGLAAGGGRPDLLARQALRTGAKVVAVTDPAAVGDVT
                     AALAALVRKTGRTRRPLPMVLAGPQGLAAAAAWSCDIVLNALPGAAGLPASLTALEAGR
                     CVALANKESLVTGGELIRRVAGPGQIVPVDSEHSAIMQCLPGWAYACPVPGLRRLVLTC
                     SGGPFRNHAPAQLAAITPAQALKHPTWRMGPLVTVNSATLVNKGLEIIEAQMLFGLGYD
                     RITAVIHPQSAVHSMAEYADGSTLAQAAPPNMRLPIATALAWPHRPPPAVIPPLDWTRA
                     HTWTFEPVDEARFPAVALAHHAGRLGGSAPTVFNAANEEAVAAFLNGTVPFPAITQAIE
                     HALDHHIPVPDHELTLDTIRAADAWARRHTHERLHQPTPSPAYQAQEV"
     gene            complement(19716..21677)
                     /gene="dxs"
                     /locus_tag="O1M07_RS07800"
                     /old_locus_tag="O1M07_07795"
     CDS             complement(19716..21677)
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546804.1"
                     /locus_tag="O1M07_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07795"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_189862292.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 3.3e-91,
                     bitscore: 304.3, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATISATQTGQLLLDSDISPEAIKRLPARAVPQLAARIRTFLVEK
                     VCATGGHLGPNLGVVELSIALHRVFNSPEDTVLFDIGHQGYVHKLLTGRAGEFDRLRQA
                     GGLSGYLSRAESPHDVIENSHASTVLSYADGLAKARHLAGESDRAVVAVVGDGALTGGM
                     CWEALNNLGAAPKRPVIVVLNDNMRSYAPTIGALADHLQHLRGAGPDNIDWLVGAEEKN
                     NTPRTRAGTESGDGADHLSAGCHHGGDDAVLPGPLPVARNLFRLLGFAYLGPVDGHHLP
                     SLEEALSMARDLHRPVVVHAVTVKGRGYAPAEGDAADCMHAVGVLDPATGRPPTGGGVP
                     SWTSVFADELCGLGERREDVVAITAAMPGPTGVARFGERFPHRFFDVGIAEQHAVTSAA
                     GLALGGLHPIVAVYATFLGRAFDQVLMDVALHRLPVTFVLDRVGVTGPDGPSHHGMWDL
                     TLLGAVPGMRVGVPRDATRLRELLGEAVAHSGGPTALRFPKASVCADISALERHGPLEI
                     LHRSTARDVLLVTVGPLAGPAVEAARYLQEQRIGVSVADPRWVLPVPPELTELAVHHRL
                     VVTVEDNTRAGGVGTAVARAVADAGSRVPVRVLGLPGRFLSHGTRSDILAAAGLTAQGI
                     AYSVLRARADRPHHEAGQ"
     misc_feature    21660..21676
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            <22773..23411
                     /locus_tag="O1M07_RS07805"
                     /old_locus_tag="O1M07_07800"
                     /pseudo=""
     CDS             <22773..23411
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091166.1"
                     /locus_tag="O1M07_RS07805"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07800"
                     /product="L,D-transpeptidase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GGQRLDFRPQEYWKAGSTVTMKIDLEGVKGGEGITGVQSKTVTFT
                     IGRSQVSTVDLNTQTMTVVRDGKPLKSLPVSGGSPKHPTYNGQMVISEKLVQTRMDGST
                     VGFNDPNNTYNIPDVPHAMRLSASGTFLHGNYWSSSSVFGRSGTSHGCIGLHDNRGGGG
                     NTPATWFFEQSLVGDVVIVKNSPEQTVKPDNGLNGWNLSWSEWQAGSAL"
     misc_feature    22783..22802
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.22"
                     /tool="antismash"
     misc_feature    complement(23828..23841)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.94"
                     /tool="antismash"
     gene            23947..25176
                     /locus_tag="O1M07_RS07810"
                     /old_locus_tag="O1M07_07805"
     CDS             23947..25176
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538362.1"
                     /locus_tag="O1M07_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1M07_07805"
                     /product="hydrolase"
                     /protein_id="WP_189862291.1"
                     /transl_table=11
                     /translation="MGKHARRRQSRLRARVVGTTGTLAVVLGAGIGPATAAEKTAGAPT
                     ARAAALDPPPAPGQLTFPAPTGRYRVGTVDLHLRDSTRADPWVPGNQPRELMVSLWYPA
                     THTSHYPAARLPVSQQVLPGGVILPTTAGHIGAPVDHRAGKLPVLLYSPGLHGSRASGT
                     SLVQDLASRGYLVVTIDHTHDASEVLFPGGRREVNTMPPGTHASQTIAVRAADTHFVIN
                     QLSAIAHGHNPDVEHAPLPHGLTHAVNVHRIGMFGASLGGGAVPAAMHADSRIRAGANL
                     DGQLFGSEVKQPLDRPFLLFSSQHHNRNTDGSWARFWKHLHGERLDLRLRGAEHNSFTD
                     SEALLPQAPGAYGYTPPQLVPILGTIDSNRAIEIQRSYLAAFFDKHLRHRHSHLLDGPS
                     HRYPEVAFVR"
     misc_feature    23980..23982
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(25386..25395)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(27020..27034)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 aagtggaccg agtccaggac aggacaagtt ggggccagtt ggcgtgctgt gatcaaggtc
       61 ggggtcgtgg tcgcgggcga gtcgctgccc cgtggaggca tcgaagacgc cgtgaccgct
      121 gctggagacg accatcagga ggtcgtttcc gctggcgggg tcgaccccga agccgactcc
      181 gagtagcccg ccgatgggcg ttcgctgtgc ggagacggac tgccaggggt gaggtgctgg
      241 agttacgggg gcagcgagga agcgatccct cagctgctgc tggtattcgg agagcatcgt
      301 gtcctcagga tggatgtccc aggttcggcc ggggcagctt actggcggtt cagaatcagc
      361 tcgtcgtgga ccggggggcg cggtcattcg tcgatgggtt gaaggatgtg agtgaagtcg
      421 cctgtctcga ccaggccgac aaggacctgg gtcatcttgc tgatgccggc gtcgcggacg
      481 atgaggccgt ccgagcacga gaagtaggcg ccgccgaggg cctccccggt cgccgcccac
      541 cgctccatga tggtctccac ctgagcgagg gtgatgacgg tcgcgctcca acgggttccg
      601 tcgttgaggt ccacgaagac gtcgatgttg tccaccgact tcaggtcctc gccggcattc
      661 ggcaggaacg ccgcctcgaa atgctccgtg cggactctgt accagggtcc gtcccatctg
      721 cccgcttgtt cgttgtggct caccgggcga gtgtgcgggg ctgatcctct ggcttcaact
      781 gcattgttct ggcacgctgc gggcgcccag cggctggccc tcactcaccc gggcgagtcg
      841 ccacgttccc gaagccgacg ctggagctga cggcggccat ggcaagctcc ccataggcgg
      901 ccatttaccg ccccactgat ggccacgggt ttccccgcgt acggccagat ttctccccgc
      961 tcgccccgag tagtcccgct cggcgacgct ggagcgggtg aagaacagca gggagattat
     1021 ggagatcctt gaggcatacg acctcacagg cagttaccgt gccgcggccg agctggccgg
     1081 gtgcgaccac cacacggtgg cccggtatgt gaagatgcgg gccgccggcc agcatcctga
     1141 ccagcgccgt caccggtccc gggcgatcga cgactatctg ccgaagatcg aggacctggt
     1201 ggtccgctcg cagggcaaga tccgggcgga tgtggtccac aagaggatcg ccgcgatggg
     1261 cttcacgggc ggggaacgca ccacccgccg caccgtcgct gaggcgaaag cccagttcag
     1321 ggccggtcgg cggcgggtct atcggccgtg ggtgaccgaa ccggggctct ggcttcagta
     1381 cgacttcggt gacggcccgg tgatcaaggg gcgcaagacc acgctgttct gcgcatggct
     1441 ggcctggtcc cgtttccgtg tcgtcatccc gatctgggac aagacgctgc cgacggtcac
     1501 cgcgtgtctg gacgccacgt tccgaaggat cggcgggatc ccggcctacg tcctcacgga
     1561 caacgagaag acggtcacca ccgatcacgt cgccgggatc gccatccgta atccggaggt
     1621 cgtcgaggtg gcgaggcact acggcacgac gatacggacg tgtctgccgg cggacccgga
     1681 gaccaagggt ggctcggagt ccacggtgaa gatcgcgaag gccgatctgg tgccccggga
     1741 cgtgaatctg cgcgaggagt acaggacctt cggcgagctg gaggcggcct gccgcagttt
     1801 ctgcgaggag gtcaactccc gcatccacaa ggcgactcgg cgcaaacccg tcgagcgtct
     1861 cgcggaggaa gcccagcggc tgcacccgct gccgcgcagt ccgttcaccg cggcgttcgg
     1921 caccacccgc cgggtcacct gggagtcgac gatctcggtc gacgcggtgc gttactcggt
     1981 cccgcacgag ctgatcgaca cccgggtctg ggcccgtttc cacggcgacg agctgatcgt
     2041 caccgccgtc gacgagcacg gctcggccat cgaggtggcc cgccacccgc gcggtgagcc
     2101 cggctcgccg gtcctggatg acgcccacta cccgccccgc gaggacaagg gaacggaccg
     2161 caccccgcgg gccacgtccg ccgaggaggc cgcgttcctc cagctcggcc cgggtgccgc
     2221 gagttggctg atcgaggccg gggcggccgg ggttcgccgg gtcaaggcga agatggccga
     2281 ggccgtcgcg ctgtcaaagc tctactcggc agcggaagtc gaccgcgcgc tcggcaccgc
     2341 cgcggtcacc gcccgcttcg ccgacaagga cctgctctcc atcctcgact accaggccgt
     2401 ccacggcatg gccgagcccg tccgccgcag cgaggaccac tcgctgcagc ccggcacctc
     2461 cgcctggtcc gccctcggcg ccccggccac gagcactccc gatctttccg agtacgacga
     2521 aagcgacctc gcctgatggc cacccctctt cgcaccgttc ccggcaccaa cggcgacccg
     2581 ctcgccgagg ccatcgagct caccaagcgc ctcaaactcc cgcacatccg ccggtcgttg
     2641 accgacatca tccccaccgc gaaggcccaa cgctgggatc ccgccgaggt cgtccgcgtc
     2701 ctgctggcgg aggaggccgc cggacgcgac cgggccaacc tccacacccg ccgcaagcgg
     2761 gccggcttcc ccaccggcaa gaccttcggc gactggcacg agggcaagtc gtccataccc
     2821 aggcccaccc aggacgccct gaagagcctg gaatgggtcg gccgccggga gaatttttgc
     2881 atctgcggac cctcgggcac gggaaagtcg cacttcaccg aggctctcgg gcagaccgcg
     2941 gtcgaagccg gcctgaccgt tgcctggttc accatcgagg acctgggcgc cctggtccgc
     3001 cgccaccgcg ccgacgactc catcgcccgg gcgctggcga agattgtccg ctcggatttg
     3061 atcatcgtcg acgacattgg actgctgccc gtttccgagg acgccgccga gggcttctac
     3121 cgcctggtcg acgccgccta cgagcgacgc tcgatcgccg tctccagcaa ccttcacccc
     3181 tccggattcg acgagatcat gcccaagacc ctggccaccg cgaccgtcga ccggctactt
     3241 caccatgctc acgtcacggt cactcagggt gattcgttca ggttcaccga ggccaccacc
     3301 ggaaagggag tgaagccctt cagctgatcc acaccaacca ctggcgggga gataactggc
     3361 cgccagcggg gactcctaac cggccgccag cagggagaac tactggccgc ctacggggag
     3421 caccacacgg ccgttgacag gagccgaagg atctcgccat gggcagcggc cagccgttgt
     3481 tcgagctctt ggatgcgctc gcggtgaacg gcgcgttcgc ggcggagggc ctcggtgagg
     3541 ctatggatca ccgtgccgtc gtcggctgac ggctcctgac gaagagcctg gtggtcagcc
     3601 cgttgctggc cgcacagagt ttcgatgcgc ttgcgcaaat cggtgtgggt gtagaggaag
     3661 tccaggctga cgcccgccgc gcgggcgaca gcccggaagt tgatctcctc gcctgctttg
     3721 accagtcgcc ggatgcctgt ctccgctcgt tggacggccg gtgcgcagtg gcgctggcgc
     3781 ccgtgccgac ggcgggccgg gcgtccggct cactgccggg gtgcggcggc gtggtgagga
     3841 tgagccaggc gcgagcgcag ctctggcagg ggaagtgcgc cgtgttctcg gcgatcggtg
     3901 cgagatcggg tgagtgcgtg gcgcaggccg tcaacggctc gtcgccgagc aggactccgt
     3961 ggtgggcggt gccgttcgtg gggccaatgg aaagccggat caagggcagg ggcgagcaga
     4021 cctccaggag aaaaggtgtc gggtacgggc ggagctgggg cggcgtcaga ggacgctgca
     4081 gcggccgggc agagtggcga gcacacgggc gtcgtcggcc gcccgtgcag cctcgacccg
     4141 ggcgaaggtg gccgggcagg cgccgtactg gcggcggttc agctctgcgg cctcggtgca
     4201 ctgcccgtct tcgatgatgt accgggtcac cttccgaacc gggaccgggc tggggggaag
     4261 gtccgagacc agcgagagca cagaggaccc gccccggttg tccgtgtccg acagcgcctc
     4321 ctcgaccagg agcgtgagac ggcgaaaccg ctccccactg acggggccga ggacgagctg
     4381 gttgccgccc aggtagagga tctccgcgag ggcttcgcgg cccaccatcg ggcgagtcat
     4441 gtgcagatag tgccgtcccg gcccggcatc cacgagggcg tctgcgagga cttgcccgcc
     4501 acgggacatg gacgacggcg aagaagaaat gggttggtcc tccttactca gtagtggcga
     4561 ccgccgtgcg gtgggagagg agcggccggc ttggagcgcc cgtcgtcagc tgcggcggac
     4621 gacggtgagc cgctcctgcg cgatcttcgg cagcgtgcgc cgcggcaccg ggaccggcga
     4681 ggcgagtgag gacgcgaacg cggcaaccag atcgtgggga acgctcgcgc tgaagctggc
     4741 gcaccatagg tacggtgcgc ccaggacggg ttcggcccac gcctgccagc cgagaaggtc
     4801 atcgcgcggg tccgcatcgt ggatgagtgg cggcagcatc tccagggaga cgtggccgga
     4861 gaagccgggg tccgtggcgg tcgtgcgggg gcggtccatg tcacgcagcc agccccgcgc
     4921 actcagcgcc gtgagcaccg attcagcgct cgcgaaccct gtgtcggggg cctcgcgggt
     4981 gtcgagggcg agcaggaggt cggcgagcgc ttcgtgcggg acgccggcgg tgaagtacgc
     5041 gttccactcc gtcatggcgg agtcggtgtg gggacgggcg gacagctgcc aggccacggg
     5101 cagtccgccg agttcgaacg ggtagctggc gaggatccac tcagcgccgc gcagttcgtc
     5161 cgggctcacg tacaccaggg tgttgcggga ggtcggccac atgcgccagc cgagcccggt
     5221 cagggtgtcg ccgatccact cggcgagggc gtcgtcatcg ccggccagat ggcgcggggt
     5281 gacccagtac accggatccg gcgagtcggg gcgggagggg gcgatggggt ggtgcgagtt
     5341 cagaggcgcc tccgtgggtt cagggggggt tcactgaccg gcgctcggcc ccgttgcgcc
     5401 gcgccggcgc cgcgggggcg cttcggtcgg ctcgtgccag gtgacggcga cagcgacgtc
     5461 gggcggcagg tggccgagct gctcggcgtc cttagcctcg gtaatgaaga ccaccggttt
     5521 tccgtgctcg tccgtggcgg cgatcacgtt gcctaggcgg taggccatgg ggaacatcgg
     5581 gttgatggcc aggcgggcgg gtgcgtcgcg gtcgcaggcc gacaggaggt cgatgagttc
     5641 tccgacggtc atctcgcgcg ggtgcgattc caaggctttc tccaagcggt agcgggcggc
     5701 cgggccgccc aacggcaggg gcagagtgcg cgtcacgtac gaaccgcagg gtgcggtgag
     5761 caggtcacag gggccgagag gtggccagga ccttggccac ggtggcggcg acaatctccg
     5821 ctggggtctc ggtgccgaac gagatgtggt agccgggcac cttcgcggtg ccggaaacgg
     5881 tgagcctcca gccctccccc tcggtgccgg gccggcccgc cgggtaccaa ccgaggtaga
     5941 agctgccgtc cttgctccct atgtggacat cggcgcggtc atccacgacg aggctgaagt
     6001 cctcggcgct gaactggtcg atgaccagcg tcggctggcc ggggcccagt tcccaggagc
     6061 ggagccgcag ggcctccacc gtcgtggcga atccggctga ggctacatcg acagtcctgg
     6121 gcatcacctc tctgacctgg ggtttccggg gaaggtcgtc tacgttgaca tgcccctgaa
     6181 gcttccacca gccctttcgc gatctttcct gtctgcccca ggcgaactag cgagagcagg
     6241 gcgaacaggt tccgcacgat ggcctcgacg accgtatccg agcacccgat cgacagcggc
     6301 atcacgacac cgaccaccgt tcagcggagg tcagagtgct ggtcagctcc tgcgccagca
     6361 accgtccgcg cgggatcagc gtgccgctcc cagtctgcga ccacccttcc caaaccgccc
     6421 cggcgggtgg ttacccgcgc cacgcgggca ggccccggtg gtcatgacag ccaccccggc
     6481 gacgtgcccg cgtcttggcg cgcgcctcgt ggcaacggga gcgccccgcg cgtcatgaga
     6541 ggctccgccg aaggcagctg acccttccta ggcccaatac cggtgacttt gtgtgtcgtg
     6601 ggtcgttggg tgtggaatgc caaggccggg tcaggtgaag tcgtcgtcgg gtgagcgtct
     6661 gtcggatcgg attgctctgg gagtgctgac gcgggtgttc ccgcctgagt tggtggatga
     6721 ggtgatcgct gagtgcgggc gtggggaaca gcgggcccgc ctgttgcggg tgtgtccagt
     6781 agacggctga tccagttttt gtagaggtca gttggcggcc ggggtgagtc ggccttcgaa
     6841 ggcgatctgg aaggcgttca ggggcgcctt ccagcgcgtg gtccatcgct tgcggccctt
     6901 gccggttggg tccaggctca tcagggccat gtagatgcac ttcatggccg cggtctcgtt
     6961 ggggaagtgg ccgcgggcgc ggacggcctt gcggatgcgg gcgttgacag aactcgatcg
     7021 cgttcgtcga gcagatgacc ttgcggatct cgacgtcgaa ggagaggagg ggcacgaact
     7081 gaagcccagg cgttctccca gagccggatg accgccgggt actttttccc ccaggcttct
     7141 tggaactcgc cgaaccgctc ggtcgcggcg gcctcgttcg gcgccgtgta gacgggcttg
     7201 agcgccttgg cgatcttgtc ccagtcttgg cgggccgcgt gccggaagct gttcctgggc
     7261 aggtgaatga cgcaggtctg gatcaccgtg cgcggctata ccgtctccac cgcttccggc
     7321 aggcccttca acccgtcgca gaccagcatc aggacatcgt cgacgcccct gttcttcagg
     7381 tccgtgaaca tgctcagcca gtacttcgcg tcctcgccgc cgtcgccggc ccagatcccc
     7441 aggatgtccc ggtggccctc ggtggtcacg gccatgacgg cgtagaccgg acggttcgcc
     7501 gcctggccgt cccggatctt cacgttgatc gcgtccacga acagcaccgg gtaaacgcga
     7561 tccagcgggt ggttggagca tcccgccatc ccgtccgtca cgttgtcggt gatcgtggag
     7621 atggtcgcct tggacacgct cgcgccgtag acctcggcca gatgcgcgaa gggtctcccc
     7681 gcgcgtcaga ccttcgccga cagcggcaac accctctcat ccacccctga caggcgccgc
     7741 tgccgcttct tgacgatctg cggctcgaac gaacccgcca cgtcccgggg gaccttgacc
     7801 tcgaccgggc ccacatcggt cagcaccgtc ttcgcccggg tcccgttgcg gctgttgccg
     7861 ctgccacggc cctgggcatc acgcttctcg tatccgaggt gatcggcgat ctcgccctcc
     7921 agggcggact ccagcacccg cttgtcagct gctggagcag cccgccctcc ccggtcagct
     7981 gcaggccctc cgaccgggcc cggtccacga gcatcgcaac caactgctcg tcactcgccg
     8041 ccacggcctc cgctgccggc tcgccgcccg gtatctgctc gatggtcgtg tcgctcatct
     8101 ggcgtctcct tgatcatcgg atccgccaat cattgaacac tccccgccgt cggccagtga
     8161 cacgagagtg gtgcggcggt tcaggtagtc atgaggcggt ggtagtcctc gacctgctgg
     8221 gccaggccgt cttcggggat tgcggtccag gcgctcatct gggtgtagga caggccgctt
     8281 ctgagtccga ccagcgcgaa ctcgcacagg acctggtgga tccgggccac ggcgttgccg
     8341 agggagacca tgccgagctc gacaccgtcg gcggccggca gcgtcccttc gatcttcagc
     8401 gaccagcgcc gacagtccag aaaacaccct tgctataagg gagttgatat ccgccacaag
     8461 agcctgatca cggacagcta cccggcgtca ccaccgacta cgggacagag ccgaacgttt
     8521 tacagtcccg agcgggtaca tcatgtggac cttggcgcgg ccggatttga tgtggtgcga
     8581 gcggtgatac gcatggccag tccgtggggg ttcaagatga gaccgggcac cgggcggacg
     8641 gtggcgcccg gggtgggttc cagccgccac tgggcggtga tggtggccag ggtgagggcg
     8701 gcttcggtca agccaaaggt gtcgccgatg catttgcggg tgccgccgcc gaaggggatc
     8761 agcgcgctgt tgcgtccgcg ggtggtccgg ccgttccacc ggtcggggtc gaagcgttcg
     8821 gggtcggggt agagcgcggc ttggtggtgg atgaggtagg ggctgtagac gatcgtggtg
     8881 cccttctcga cggggtatcc ggcgagctgg gtgtcggtgg tggcgatgcg ggtgagcatc
     8941 cagccgggtg ggtgaaggcg caaggtttcg gtgatgatgc ggttggtgaa ttgcagttgg
     9001 ggcagcaggt cgaaggtggc gggtgcgccc ttgggcatga cggcgtcgac ctcggtgtgc
     9061 agtcgggctt cgaggtcggg gtgttgggcc agctggtgca gggcccatgc caggacggcg
     9121 gcggtggtct ctatgcccgc gtagaggaag gacatcacct ggtcggtgat ctcggcgtcg
     9181 gacaggccct ggccgtcgtc ggacgcggcc agcagtatgg acagcaggtc cccgctgttg
     9241 tcgtcccgcg cctggtggtt ctcgatgact gagccgatgg cttgccggag ccgggcgcgc
     9301 gcctggtggt agcggcggtt gccgggggtg gggagcttgt ggagcggggg tggcatgaac
     9361 atccgcttgt acacaccgcg tgagaagacg ttgaaatcgg cgagcagatc agtgagcgaa
     9421 gcgtcggagg tgtcggcgaa catcgtggcc agggtggtac gggcggtgat cgtctgcatg
     9481 gcggtgagga cgtcgacgat gtcaccgtcg ccccagcggc cgacggcctc ggcgatttgc
     9541 ttgctcatca tctgggcgta ggccggcatc cgctgggtct ggaaggcttg ttgggtcagg
     9601 cgacgctgcc gcctgtggtc gccgtgcggg caggtggcga gtccgttgcc caggccctcc
     9661 ctgccccgct caatgagcgg gccgcccttg tcgaaggtgc ggtcgtccag caggaccttc
     9721 tggaccaggt ccgggtcgca gagcaccagc gcggccgccg ggcctagctt gacccgcacg
     9781 acatcgccgt gggcgggcag cgacaccagg aatgccagtg ggtggcgtcg cagggacagg
     9841 gcgtggccga gcagcggcag cgaacccggg gctcgaggga tggtgcgggc gatgcccatg
     9901 atgtgctcct aaggtcaggg ccgggcgagg gggcatggcc gtccgctgaa ccgtcagcgg
     9961 catccggccg ttactgaacg ggcgtgggtg caaaaagtcg ctaggacggg gtttcgcccc
    10021 ctgccgcagg cggagcggtg tagcggctgg tttgggaggg gtagtcgaag cagccgcgga
    10081 cgaatttccg gtacccggcg gcgcaagtga gcgcgtcgtg gcggacgtga ccggtgatgc
    10141 gcgcggcgtc gagctgggcg gtcaggtctc gttcggcatc cggcatacgc cggacgcggt
    10201 ctgtgaacat cgtgttgacg gcatcgacag catcctggag cggaaggcgg tcgtggtgct
    10261 ggacgaggag gaccgcgttg tggaaggcgc cggcggctgt gtcgagttcc agggaccaca
    10321 ggtcgttgtg aaggctggtg tactggctgg tggcgtactg gagaagtgcc gcaccgtttc
    10381 aggcaggtcg atcccggcag cgatctccac cacgtcgagc agggagtagg ccgcgccggc
    10441 caccgcgcgc tggcgccggt aggcggtcac cgtggggatc cgaccggagc cctggtcgac
    10501 caggctctgg tagaacgacc acagccaggc agagatggcg ctgcgcggca cgcggtcaaa
    10561 ccccgcggag cgacctgcgg tcaggtcctg gagggtcgcg gcgacggccc acccgggagc
    10621 gcaggcggca ctggacgcct ggctgggaaa gcctcgccga ggggaagggc gtagaacgac
    10681 agtgcggtgt gcaggtccgc ctcggcgtcg gccagggtcg ctccgcagtg caaagggcgc
    10741 tctacggtgt acttcgcggt ccgtgcacga gccttggcac gcattctcag tcgcttcggg
    10801 ctgagcgagc cggacctcat tcatcatgac actccacgcg cgttcgctgc tggtcaggct
    10861 ggagttggtg gtgacggcga agtcgtcgcc gaccagttgg acccgagagc ttgggtcaag
    10921 gtttcgtgtg agtcgccgtg cgtggtcttg tctgcatgtg cagttcacgg ggccttagca
    10981 ctgtgcccag ggcggggcgg acttggcgcc cggaaatgtg ctccaggcgc cagcgggcgc
    11041 tgatggtcgc gagagcgagg gtggcctggg ccatggcgaa ggtgtctccg atgcatttac
    11101 gggcaccggt ggcgaagggg aggaagctgt ggcggagtgg ttgggtgcgg ttgcggtccc
    11161 aacggtcggg gtcgaaggtt tcggggttgt catagaggtc gggtcggtgg tggatgatga
    11221 aggggctgta gacgacgttg gctccaacgg gcaaggtgtg accgcccagg cgggtttcgc
    11281 cagtggtctt gcgggtgaag aaccaacctg gcggccgtag ccggagggtt tccgtgatga
    11341 tgcgctctgt cagttccagg cgaggtaggt cggcgtgcgt ggccggagcg ccttgcagga
    11401 ccgcatcgac ctcggcgtga agtcgccgct cgatctcggg atgccgggcc agcaggtcca
    11461 gcgcccaggc aacggcactg gctgtggtct ccgttccggc gaggaagaag gtgacgatgg
    11521 tgtcgctgat ttcagcatcg gtcataccac tgccggcatc ttcggcgtcg tgagccgcca
    11581 ccagggcgga aagcaggtct cctcggtcac tgccgtctgt gcgacgctgg tggacgatac
    11641 cgtcaagggt gtcgtgcagg cgggtgcgtg catcccggta ggtgcggttg ttccgggtgg
    11701 gtgcccgatc cagcggaggg atcaggaaca tacgctggta gatgccgtcg aagaccgtct
    11761 tgatgtcgtt aaggagttga ctcagatcgg ccgggggcag cgcactggaa aacaaggtgg
    11821 cggccgtgac cttgcaggtg atgctcatca tctcggtggg tacgtccagg gtctggttcg
    11881 tttgccagga accggtcacc tggtcaaggc aggcggtcat ggcctgcccg taggcgggga
    11941 accgcgcggg atgaaaagct ggctgggcca gccgtcgtag tcgacggtgt tcactgtggg
    12001 ggcaggttcc gagaccgtca cccataactt cccgtgcccg gtcgtagagc aggccgcctt
    12061 tgtcgaaggt acggtcgtca accaatgcct gacgggtcag ttccggatgg cagatcacga
    12121 tcagtgtgaa ggggcccaat cgaatacgga ccaagtcacc gtgagcgggt agcgaggtca
    12181 agaacaccaa cggatcccgc agcaacggca ctaagtgacc gacgaaaggc agtccttgag
    12241 gagctgcagg gatcgacttc aaagccttca tgagcactcc gctccggttg gggattcttg
    12301 agagtcttgg ctgaacgcag acgaagacca gtacgtcccg caaggtcggt cacctcgtcg
    12361 atggcggtcc tcatctgcgt gaaggcggca ccactggctg caggcagcga aggagacgtg
    12421 ccgcgccggg gtaacgcgtg gtggacagcc cgacatgggc acgaaggttg ccgtcgacgg
    12481 tgctggtcag gatggtggcg aggggaccgg gagttgtgtt cctcagggtt gcggcgatgt
    12541 ggttgtagcg gtcggtgacg gtggtgatca ccgcattcag atcccgaccg gagcaggccg
    12601 catggaatcg gactatattg gacgtctcgt attcacctgc gccaccggac gcggtttcct
    12661 tgtccaaaga cgccaggtcg ttggcgatgt agatggcctc gagggcctgt tcaaccaggt
    12721 tctcctcatt cggcaccggc aggttacgaa cagctcgccg acagtcgata tagggcttgg
    12781 ccgcaacggt gaccattcgc aggtcgtgaa actgctcctg cgtcatcgtg cgtgcgtcac
    12841 gggccctttc agtcacagcg gcggcacaca gttcggcaat cctggcctcc acctgtttgg
    12901 tgtcgaggcc gtgggctcga aggtcggcca gcagggcatc gtgcagggtt cccagctcgc
    12961 cggcgcggac gggccgaccg gagcggagct ggtcggccag ggcttccagc tcgttgtgca
    13021 atccgtcatc taggctgaag aagaaggtga tgtacttggc gcacagcagg ttctcccgtt
    13081 cagcggcatc cggcggcgca cagtagcgct cgaacgtcgc tgcgtagaac gcctcccggg
    13141 cgtgccaggc agatccgcga ttgcaggagc acaattgcag ggaccaggtg agcagggcct
    13201 tggcgagctc gcggtgtcgg tcgtcagcca tgtgccggtg atagggcacc aggaggtcag
    13261 cggtcatgat cgtggccgtt cctgctcggg gtgggttgca gggcgcgcag agcgaaggct
    13321 gtcgtgaggt gagcagagcc gacgtaccga gggatgcgcc ccatgcggaa gtaggggcag
    13381 gccggccagg atccgtcggg tagttgtgct gctgcttcat cgtcgcgtag gacggtggta
    13441 tgcccagctc cggctcccca tggtgtgtgg ttcatgtctg tcgttcctgg tagtgactgt
    13501 ttgtgctgag gacggagctc agccccgtga ccgcgaaggc ctgggtttcg atgggcatgt
    13561 gagtcagcag ggggcggggg ccgagcatct ctggcacacc gggccaggtg ccgtcaccgc
    13621 actgtgtcct gatcagaaat gcccgagcgg ccaccacagt agggctgcca tccccttggc
    13681 atcgggcgag cgcggcggca gcaagtccgg tggccgaggc gcagctttgt tctcctgcca
    13741 tgcggcccca gccgccatca gaattctgcg atgcggccaa tgcccgtccg gcgtcttgca
    13801 cgagtgagtg ggtgaacccc agtgcccggc ccacttcgag ctgggcgtac gggctgttgt
    13861 ggtaccagcc ggcgcgccac ccgccgacgg aggatcggta ttgggcttcc agccaatggc
    13921 gggcaggttc caggggaacc cggtggtatt cggagaaccg gtcgaggcca gccagcacgt
    13981 gggcgaccac gtcctgcgcg ggcgggtcat ggtcgaattg ccatgtgcgc cacaggccgt
    14041 tgccgtcctg ctgtcgggcg aggtagtcga tcgcctgacg gatctgctcc ttgtcctgcg
    14101 tgtcggtggg caacgcgagt agggctgcgc cggtggtgtc gctgtccgac tgggaatgac
    14161 caccgaatcc ccagccgccg tcgtcgttct gtctcccaga caggaactcc agcgccgggc
    14221 gcagggcccg ctcgcggaag aggggatgct ggccgagcgc ccggatgacc agagtggtgt
    14281 cccacacgtc acaggtgcag aaccgccatg tgccatctgg ctgttgggca tcgaggagcc
    14341 actggcaacc ctgtcgtacc gccacgccat ccggatcact tacgtgcaag gccagcaggg
    14401 ccatcgaggt gctgatggga ttctgcgaga acgatccgtc cacggcctga tgggacttga
    14461 tccgtccgac ggcttccgca gctgcggctt catcgccgaa gaacgattcg atcaacgccc
    14521 ggacggccaa cagttccacc gtgctccaag gcttgagatt ctgtcgcgcg tagttggcat
    14581 aacgtcggcc gatctggtcc cgcacgtctt caggtggtgg cccggcgtcc acgctgcgcc
    14641 gtgcgctcag ggcaacggca tacaggagta gctggcgcga tgagtagacc gcgtcggtga
    14701 aggtgtggtg ggacaggtcg atgtacgcag cctggtccag ggcgatatca cgcaaggtct
    14761 gctcgactac cgtcgcgact gggtgctgtt cctgtggggc agccgtcgtc agccatcgcc
    14821 tcgcccgtga gagtgcggcg cccacgtcgt tgctcaccag gccaacgggc tggagagttg
    14881 ccagtgtatg gagtgacaga gcggtttcca ggatccgggg ctctggcagc attgcccacc
    14941 cgccggattc atcctgcgtg tccagcaggt actcaaccgt gcgctgcagc gcggacgcta
    15001 tcgtatcgat cgctgagacc ggcatgccgt tcctcctacg atgaccacgc ctcaagcggg
    15061 ctgtgcctgt gatggctccg tacctgatgg agcactttga gcagtgcggg ttcaactggt
    15121 gcaatgggat ttgtggaatt cgtctcgact acggctgcgt ggcacgggtt cttctaggcg
    15181 ccagctctcg tgggagggca aactgctggg cttcctccgc cgcggtgacg gtggtgacat
    15241 cctggtagcc gtgccgggcc agccacttca ggacctgctc gaccaggatg tccgggaccg
    15301 aggcacccga ggtgacaccg accgtcatga cgtcgtccag ccaggtttcg ttgatctcgc
    15361 tggctgcgtc aatgaggtgt gcgtcgcagg cgccggcgag tttggcgacc tcgaccaggc
    15421 gctgggagtt ggaggagttg ggcgagccga cgacgatcac catctcggcc tgttgggcga
    15481 tctgtttgat ggccgcctga cggttctggg tggcgtagca gatgtcgtcc gagggcgggg
    15541 agatcaggtg gggaagcttc tccttgaggg tattgacggt ctctgtcgtc tcgtcgacgg
    15601 agagcgtggt ctgggagagc catacgacct tggactcgtc gcgcacctcg acgttggcgg
    15661 cgtcgtcggg gctgtcgacc agcgtgatgt gttcgggggc ctcgcctaag gtgccgatga
    15721 cctcctcgtg gccttcgtgg ccgatcagga ggatgtcgta gccctcccgc gcgtagcgga
    15781 cggcttcctt gtggaccttg gtgaccaggg ggcaggtggc gtcgatggtg accaagtccc
    15841 gctcagcagc cttgtcgtga acgactggag ccacgccgtg cgcggaatag ataacggtcg
    15901 ccccttcggg gacctcatca acttccttga cgaagaccgc acccttcctc tgtagggtct
    15961 gcacaacgtg cttgttgtgg acgatctcgt ggcggacgta gaccggcgcc ccgtacagct
    16021 ccagagcctt ctccaccgtc tggatggcgc gggcgactcc tgcgcagaag ccccgcggaa
    16081 cagccagcag aacgcgtttg gttccgctgt cgcccgggag gggcgtggcc tggccggctg
    16141 tgctcatgag gtcctccatg tggcgttctc cgccaagtgc cgtagctgcc cttgcacgtg
    16201 gggagggatg ggggcctcgt agagggcggt gacggcgtgc tcgaagcggt cggcgatcat
    16261 gtgttccacc gtctggtccg cgcgcgtggc cttcagaacg gtgcgcaggg tcgcggcact
    16321 gtcctcctcc aggcgggggt tgccgtacag ggtgcgcagc agacgtgcct gcgtgtcgtc
    16381 ggccgccttg agggcgtggg cgatcaggac ggtgggctta ccttcgcgca gatcgtccag
    16441 gcaggacttg ccgctggtcg cctcgttgcc gaaggcgccg atcaggtcgt cacgcagttg
    16501 gaacgcctct cccagcggca gtgcgaaggc gctgagcgcg tcgaggaggt gctggtcggc
    16561 gccggcgagc gtggcgccga tgtgcagggg gcgctcgacg gtgtacttgg cggtcttgta
    16621 gaggatgatc tgcagagctt gctcgatgtc gccggttgcc tgtccggtgg aggtcaggtc
    16681 gaggtactgg ccgtagatga cctcttcgcg catcaggtcg atcacatcgt gcagggcggc
    16741 cagagtggtg gatgggtggc ctgcggtgtg caggagttcg tccgaccagg ccagggccat
    16801 gtcacccacc aggagtgcgg cgtcggctcc gagcttgcgt gcctgttcgg ggctgtggcc
    16861 tactccgtag tcggcggcga ggtggcggtg gacggtggga cgcccgtggc gcatctcgct
    16921 gttgtccatg atgtcgtcgt ggatgaggca gaacgcgtgg aacatttcca cggcggctgc
    16981 cgtgcgcagg agcgggatgg tgtcgccgtg accgtcggca gcgtgccagc cggtcacaca
    17041 cagcagaggc cgcagccgct tcccgcccgc ctgcagatgg cgccgtaccg cctgggcgag
    17101 gtcccggggc aggccggacg cggccgcggc atcagtcttc gcgttgagga agtcggtcag
    17161 cacggtgtcg atttgggccc gcgccgcggg caggtcgatc ggctgggccg ttgccagggg
    17221 cgtggtgttc atgagtgttc accggcttcg gcgacgggct cgttcacgga ttcagtcaga
    17281 cgcagtgcct cgtcgagcag ggcgttgacg atcttggatt cggggacggt gcgtaggact
    17341 tcgccttggc ggaagatctg gcctttgccg ttgccacagg agacgccgag gtcagcttcg
    17401 cgggattcgc cggggccgtt gacgacgcag cccatcaccg cgacgcgcag cgggtgcggg
    17461 aagccgtcga aggcggcctc gacctgggcg gcgaggcggt ggatgtcgac ttggaggcgg
    17521 ccgcagccgg ggcaggagac gatctccagt tggcgggggc gcaggcccag ggactgcagg
    17581 atgtgacagc cggccttgac ctgttccacc gggtgtgcgg acagggaggc gcggatggtg
    17641 tcgccgatgc cttctgacag gaggatgctg aaggcgactg cggatttgat ggagccttgg
    17701 aaggcggggc cggcttcggt gacgccgagg tggagggggt agtcgcattg ctgggcgagg
    17761 agccggttcg cgctgaccat ggtcatgggg tcgtggtgct tgaccgcgat cttgatgtcg
    17821 caaaagccgt gctcctcgaa cagcgagcat tcccacaacg cggattccac cagtgcctgt
    17881 ggtgttgccg caccgtactt ggccagcaga cgctggtcga gggagcctgc gttgaccccg
    17941 atgcgaatcg gcacacgggc tgcttgggcg gctttagcta tctcaccgac tctgtcgtcg
    18001 aacttcttga tgttgcccgg attcacccgc accgccgcgc agccggcgtc gatggcggtg
    18061 aagacatagc ggggctggaa gtggatgtcc gcgatcaccg ggagcttcga cttcgccacg
    18121 atgtcgggca gcgcgtcggc gtcatcctgg gagggcacag cggcacggac gatgtcgcat
    18181 ccggcggcgg tgatctcggc gatctgctgc aacgtggcgt ccacgtcggc cgtgttggtg
    18241 gtggtcatgg tctggacgga gaccggtgcg ccgccgccga cggggacatc gccgacatgg
    18301 attcgtcggg tgcggcggcg caccggagta gtgggaggcg gggaggggag gccgagatcg
    18361 atggcgggca tgtcagacct cctgcgcctg atatgcggga ctgggcgtgg gctggtggag
    18421 gcgctcgtgg gtgtgccggc gggcccaggc gtcggcggca cggatggtgt cgagggtgag
    18481 ttcgtggtca gggaccggga tgtggtggtc gagggcgtgt tcgatggcct gggtgatggc
    18541 ggggaagggg acggtgccgt tgaggaacgc ggcgacagcc tcttcgttgg ctgcgttgaa
    18601 cacggtcggg gcactgccgc cgagacggcc tgcgtggtgg gccagggcga cggcggggaa
    18661 cctcgcctcg tcgacgggct cgaaggtcca ggtgtgcgcc cgggtccagt ccaggggcgg
    18721 gatgacggcg gggggtggcc ggtggggcca ggccagggcg gtggcgatgg gcaggcgcat
    18781 gttcggcggg gccgcctggg cgagagtgga gccgtcggcg tactcggcca tcgaatggac
    18841 ggcggactgc gggtgaatga cggccgtgat gcggtcgtag ccgaggccga acagcatctg
    18901 ggcctcgatg atctccaggc ccttgttgac cagggtcgct gagttcacgg tgaccagggg
    18961 gcccatccgc caggtcggat gcttaagggc ctgggcgggg gtgatggcag ccaactgcgc
    19021 gggcgcgtgg ttgcggaagg ggccgccgct gcacgtcaag accaggcgtc gcaggccggg
    19081 tacggggcag gcgtaggccc agccgggcag gcactgcatg atcgcgctgt gctcggagtc
    19141 caccggcacg atctgccccg gccccgccac ccgccggatc aactcgcccc cggtgaccag
    19201 ggattccttg ttcgccagcg ccacacaccg cccggcttcc agagcggtga gcgaggccgg
    19261 caggcccgcg gcaccgggga gggcgttgag cacgatgtcg cacgaccatg cggcggccgc
    19321 cgccagccct tgcgggccgg ccagcaccat gggaagaggc cgacgggtcc taccggtctt
    19381 ccgcaccagt gcggcaagag cggcggtaac gtccccgaca gcggcggggt cggtgacggc
    19441 cactaccttg gccccggtgc gcagggcctg gcgggccagc agatcggggc ggccaccgcc
    19501 cgcagccagg ccgaccgccc ggaagcggcc cgggtaggcg gtgatgacgt cgagtgcctg
    19561 tgatccgacc gagccggtcg atcccaggac caccaccgcc cgcacaccat catccccgcc
    19621 gaccgcggtt ggcgtcccgg ccgtctccag gatccggcgc agcggggggc gggcggagtt
    19681 gccgggcggg tgcgggaggg cagttcgtgg ggccatcact gccccgcttc atggtggggg
    19741 cggtcggcgc gggcgcgcag gacggagtag gcgatgccct gcgcggtgag cccggcagcg
    19801 gccaggatgt cggagcgggt gccgtgggag agaaaccgtc ccggcaatcc gagcacccgc
    19861 actggcacac gggagcccgc atcggccacc gcacgcgcca ccgcggtgcc cacaccgccg
    19921 gcccgggtgt tgtcctccac cgtcaccacc agtctgtgat gcacggcgag ttcggtcagt
    19981 tcaggcggta cgggcagtac ccagcgcggg tccgccacac tcaccccgat cctctgctcc
    20041 tgaaggtacc gggcggcttc caccgccggc ccggccagcg ggcccaccgt caccagcagc
    20101 acatcccgtg ccgtggatcg gtggaggatc tccagggggc cgtggcgttc cagggccgag
    20161 atgtcggcgc aaacggaggc tttggggaac cgcagcgctg tcggcccgcc ggagtgcgcg
    20221 acagcttcgc ccaggagttc gcgcagtcgg gtggcgtccc ggggaacccc cacccgcatc
    20281 cccggcaccg cgcccagcag cgtcaggtcc cacatcccgt gatgtgacgg cccatcagga
    20341 cccgtcaccc ccaccctgtc cagaacgaac gtcaccggca gccggtgcag cgccacatcc
    20401 atcagcacct ggtcgaaggc acggcccagg aacgtggcgt agaccgcgac gatggggtgg
    20461 aggccgccca gcgccaggcc cgcggcggac gtcaccgcat gctgctcggc gatcccgaca
    20521 tcgaagaagc ggtgagggaa ccgctcgccg aaccgggcca caccagtcgg acccggcatc
    20581 gccgcagtga tcgccaccac gtcctcgcgc cgttccccca gcccgcacaa ctcgtcggcg
    20641 aacacactcg tccacgacgg cacgccaccg cccgtgggcg gccggccggt ggcggggtcc
    20701 agaacaccga ccgcatgcat acagtccgcc gcatcgccct cggccggggc gtagccacgg
    20761 cccttgacgg ttaccgcgtg caccaccacc ggacggtgca gatcccgcgc catcgacagg
    20821 gcctcttcca acgacggcag gtggtggccg tcgaccgggc cgagataggc gaaaccgagc
    20881 aggcggaaca gattccgggc caccggcagc ggccccggca gcacggcgtc atcccctcca
    20941 tggtggcaac cggcgctgag gtggtctgcc ccgtctcccg actcggtgcc ggcacgggtg
    21001 cgtggcgtgt tgttcttctc ttcggcacca accagccagt cgatgttgtc ggggccggcg
    21061 cctcgcaggt gctggaggtg gtcggcgagg gcaccgatcg tgggggcgta ggagcgcatg
    21121 ttgtcgttca ggacgacgat gaccggacgc ttgggcgcgg cgccgaggtt gttcagcgcc
    21181 tcccagcaca tccctcccgt cagcgcaccg tccccgacca cggcgaccac cgcacggtca
    21241 ctctcacccg ccagatgacg ggccttggcc aggccgtcgg cgtaggacag gacggtggag
    21301 gcgtgggagt tctcgatcac atcgtgcggg gactcggcac gggaaaggta gccggacagg
    21361 ccgcccgcct gccgcaggcg gtcgaattcc ccggcacggc cggtaaggag cttgtggacg
    21421 tagccctggt gaccgatgtc gaacagcacc gtgtcctcag gggagttgaa cacccggtgc
    21481 aaggcgatgc tcagctccac cacacccaga ttcggtccca ggtgcccacc agtcgcgcat
    21541 accttctcca ccaggaaggt ccgtatccgg gcggccagct gtggaactgc cctcgctgga
    21601 aggcgcttta tcgcctcagg gctgatgtca gagtccagca acaactggcc tgtttgcgtt
    21661 gctgaaatgg tggccatcgc aggcctcttt cgcagaagag cagcccaggg ccatacaccg
    21721 gatcactgga ggcagatacc cgccccgtgc acacagtaga aatatgcgca cagcgcctct
    21781 tccacgcaca gactgcgagt gctcccgaac ccgtgaaggc acacaccacc ggcactttga
    21841 cgcacatgcg ccgcatcaaa gtgccctgtg gcgaaccgct cgttgagtgg tgctaccagt
    21901 acgcccccgt aacgagccat gcgcaagagg attcggcaac gtgggtgttg aacgcgttga
    21961 atgctcgcgc tggcgaacaa cccgcggcac tcagagcccg ggagccatca tgcgttcgtg
    22021 gtcatgacaa tccgactcac gaaacgccag gccccgcacc ttccgcgctt gcagagcagc
    22081 gaaaccacac agcggcctca cggcctgaca tcctagctgc caccgctctc gcactgaacc
    22141 gtagcgaatc cgcgccttgc ggatgggcct ggccccgtcg acgtcgtacc actgctcatc
    22201 aaagccaacc cggtacgtca gctcgtcgac acgtgcgtgg gacctcgacc atgtccccgt
    22261 atcgccgagg ctgactcatc tccgagtgct tcgcgggcag cgcgatcacc gcctgccgca
    22321 gatcccgtgt ccttcccctc gaaagggcat gcggagatag ggcttgccaa ggcgcacgtc
    22381 cggtatttcg gtcgtcggtt tggtctggcg acttctgtga gggcggttcg tgagttgatg
    22441 tccgtttctg gatgaggctg gggcagggct gctggtcacg tgctcggtcg gctactgctt
    22501 cctgatgaag ctgccgacgt cgacctcggt gaggatgccg agcttgacca ggcgtttgag
    22561 tttggcgcgg gtgttttcga tgttcttcgg cagcagttcg tggtcgaggg cctggcagac
    22621 gtcgcgggcc cggaggggga cagtggcctc attgaggacg ctgaggatgc gggggtagtc
    22681 cgggcgctcg ggtaggtcga gcgggtcggc ctgggccggg atccggtcgg cgagggtggt
    22741 gacggtcttc cgcgtgatcg cgaggtgttc gaggcgggca gcgcctggac ttccgtcccc
    22801 aggagtactg gaaggccggc tccacggtca ccatgaagat cgacctggag ggtgtgaagg
    22861 gcggcgaggg catcaccggc gtgcagtcca agacggtgac cttcaccatc ggccggtccc
    22921 aggtctccac cgtcgacctc aacacccaga ccatgacggt ggttcgggac ggcaaacccc
    22981 tcaagtccct gccggtctcc ggtggcagcc cgaagcaccc gacctacaac ggccagatgg
    23041 tgatctcgga gaagctcgtc cagacccgga tggacggctc caccgtcggc ttcaacgacc
    23101 ccaacaacac gtacaacatt cctgacgtgc cgcacgcgat gcggctgtcg gcctccggca
    23161 ccttcctcca cggcaactac tggagcagct cgtcggtctt cggccgctcc ggcaccagcc
    23221 acggctgcat cggtctgcac gacaaccggg gcggcggggg caacaccccg gccacgtggt
    23281 tcttcgagca gtcactcgtc ggcgacgtcg tgatcgtcaa gaactcgccc gagcagaccg
    23341 tgaagccgga caacggcctc aacggatgga acctctcctg gtccgagtgg caggcgggca
    23401 gcgcgctgtg atgacgggtg tcctcatccg cgtaattccg ccgtgcacgc ccaccgtcgc
    23461 gcacaaggcg cgcgcagggc gtacgacggc gaatacgagc gacaacccgc aagggctccc
    23521 gctcgcgatc cgcagaggga attagtaccg catcttcacc acgtcttcaa atgccttgtc
    23581 ggcaactcgg ccactgttac tgggtagttc ggtgaaatgc acagggttat gggataccac
    23641 cggggggctt caccggcgca gtaaattgcc tgtcgctggg cgtgtttgcg cagttcgtga
    23701 cggagcgctg agtggagcga cccggcactc acagtaaaat cacgggtttt ctcctcctgc
    23761 gcaatcgcgc gcatggcgtg gcccgacaat gggagtccag tcgggccaac tgtggccaac
    23821 tgtgcggtaa taagaactct ccgtacggga aaggcacttg ggccgacctc ggcgaattac
    23881 ctattacgat gagcgccaac cgaacgccgg tcgggtggtg ttcgccgtct gggagaggag
    23941 ctgcccatgg ggaaacacgc acgaaggcgc cagagtcgtt tacgcgcccg ggtcgttggc
    24001 accaccggga cactggccgt cgtcctggga gccggtatcg gccctgccac cgccgcggag
    24061 aagaccgccg gtgcgcccac ggccagggcg gcggccctgg atccgccgcc ggctccgggc
    24121 cagctgactt tccccgcccc gaccgggcgc tatcgcgtcg gaacggtcga tctccacctg
    24181 cgcgactcga cccgtgcgga tccgtgggtg cccggaaacc aaccgcgcga gctgatggtc
    24241 tcgttgtggt atccggccac gcacaccagt cactaccccg ccgcgcggct cccggtcagt
    24301 cagcaggtgc tgccgggcgg ggtgatcctg cccaccaccg ccggccatat cggtgccccg
    24361 gtcgaccacc gggccggcaa gctgcccgtg ctgctctact cccccgggct gcacggaagc
    24421 cgggcatcgg ggacctcgct ggtgcaggac ctggccagcc gcgggtacct ggtcgtcacc
    24481 atcgaccaca cccacgatgc ctccgaggtg ctgttcccgg gcgggcggcg tgaggtgaac
    24541 accatgccgc caggcaccca tgcgtcccag acgatcgccg tgcgggcggc ggacacccac
    24601 ttcgtcatca accagctgtc cgcgatcgcc cacggccaca acccggacgt ggaacacgcc
    24661 cctctcccgc acggcctgac ccacgccgtg aacgtgcacc gaatagggat gttcggcgcc
    24721 tccctcggcg gaggagcggt gccggccgcc atgcacgcag actccaggat ccgtgccggc
    24781 gcgaacctgg acgggcagct cttcggctct gaggtcaaac aaccgctcga ccgccccttc
    24841 ctgctgttca gttcccaaca ccacaaccgc aacaccgacg ggagctgggc gcggttctgg
    24901 aaacacctgc acggggagcg gctcgacctg aggctgcgcg gcgccgagca caactccttc
    24961 accgattccg aggccctgct tccccaggca ccgggcgcat acgggtacac cccaccgcaa
    25021 ctggtgccga tactcggcac gatcgactcc aaccgcgcca tcgagatcca acgcagctat
    25081 ctcgcggcct tcttcgacaa gcacctgcga caccggcaca gtcacctgct cgacggcccc
    25141 tcacaccgct acccggaagt cgccttcgtg cgctgaacca gcggaaggcc gccacccgac
    25201 gaccgcacag cgcgacggca tgtcacggcc atccgcctgc atcccccacg tgccgagagg
    25261 acttctgccc tgcccccggt agctcacgcg ccccgtcccc accgtgcgcg acgccgtgcc
    25321 gacatgcctc tgctcggagg agtccgccca ccgatcgccg ctctgctctg cgcactgctg
    25381 gcagtcgccg ccttccccac cctcgctctc ggcaccgtcc atgaccagga agtcccgcag
    25441 gcggtacgcg ttgcggaacg ccggatcgcc gaggacgcgg cggcctcggt gcgggccgcc
    25501 gtcgacacca gtgccatggc ggtgcgcggt tccgcggcgg ccgccaccct cgccgacggc
    25561 agtactccgg cggccgtcct gaagtccctt gtccctgccg gtcccccggc gccggcgctg
    25621 gggggtgtgc tgatcgaccc gcggacgggc aggcccctcg cgaccagtgg tgcggcggtt
    25681 ccgttgtcgg gtgtggatgc ggcggctctg atgcggccgg gcaccgcgaa ccccgcgccc
    25741 cggttcgtcc cgtcggggag tgccggacct ctgctgttgc tcttcgcccg ggtgaccgtg
    25801 ccccatgcgg ggcatcaact cctgctggtc gtagcggaga agccggctgc tccggtggtg
    25861 tacggagacg ggcgtaccgg ccagttggtg gatggggacg ggaaggtgct cgccaccacc
    25921 ggcggcgccg gtgccgcccc ggtgcctggc gccgaggatg gcgcccggct cgccgcggtg
    25981 gtgcggacag ccgacgccgg acggtccgcc ggcgacacct ccggcagtgt gctcggagac
    26041 gagcacgacg ggttgcgccg ggtcgcgggg tgggcatcgg tcacggcggt gcacggcaag
    26101 ggcggtggaa agggcgacgg cacgtacgac ggccagggcg acagcgaggg gaacatctcc
    26161 caactggcgc tgacggtggt cacgttcagg gaggtggcgt cggccaaggg cgggggcggc
    26221 catatgtcgt tcgccctcgc cgccgcgggc gcgttggtgg tgatcgccgt gctggtcacc
    26281 ctggtgctgt ggggcaccgt gcagcgtccg ctgctgcggt tgcatctgtc cgctgcccgg
    26341 ctggccgggg gtgtctgcga gatgtccgcg gcgcggggcg ggctggcgcg gccggtgccg
    26401 gtcgcggcgt tcggcgagcc cgcgagagtc ggccgggcgc tggagtcgat acgccgtcaa
    26461 ctgctgtgcg gggcagggcc ggagcccgcg cagcgcgtac gtccggtgcg atatcggctc
    26521 ggagtgcggt ccgttctgct ggtctgcgca ctcgtgatcg ccgcatgggc gatgcccctg
    26581 ctgttcctgt tcaaccgggt accggccgac caggcggtgc cggcaacggc cgtcgccgac
    26641 cagcaggcgc gtaccgaggc cgccgccgac cgggtccggc agtccctcga ccagagccgc
    26701 accgacctcg cggcggtggc gccggccctc tccggcgcgc caccggacag ggcggaggag
    26761 atcctgcggc gagaacgcgc cggccatccc ctgtaccggt cactgtacgt actgaaccgc
    26821 gccggcacga tcgtgctgcg ggcaggcagg cggccgctgc acaccctcgc cgatgcgccg
    26881 gccggcgacg gcctcgccca ggtcaccacg tccggcagga accccacgct cgccgcctac
    26941 gcccggatcc cggcggccaa gaacgccgag ggaggcaccg caccggccgt ggtcgtcgcg
    27001 gagatcggcg tcggcgcgtt ggccgacgtg gtcgcgcggc cagggctggg ccgggtgtgg
    27061 ctgacggacg agcgccaccg ggtgctcgcg gcgaacatcg actttcgggg ctttcagccg
    27121 ttgcccaccc ggggcctggc ccgtctcgtg gccaggaccg acgcggcgcc cggcggcgcg
    27181 ggcggcccgg catcggccgt cctggacgcg gcgaccgcgc cgggcgaggg cc
//
