LOCUS       NZ_CP113837            11264 bp    DNA     linear   CON 26-JAN-2024
DEFINITION  Kitasatospora sp. YST-16 chromosome, complete genome.
ACCESSION   NZ_CP113837
VERSION     NZ_CP113837.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora sp. YST-16
  ORGANISM  Kitasatospora sp. YST-16
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 7659304)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-NOV-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 95.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/24/2024 04:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,903
            CDSs (total)                      :: 6,801
            Genes (coding)                    :: 6,649
            CDSs (with protein)               :: 6,649
            Genes (RNA)                       :: 102
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 152
            CDSs (without protein)            :: 152
            Pseudo Genes (ambiguous residues) :: 0 of 152
            Pseudo Genes (frameshifted)       :: 59 of 152
            Pseudo Genes (incomplete)         :: 103 of 152
            Pseudo Genes (internal stop)      :: 5 of 152
            Pseudo Genes (multiple problems)  :: 14 of 152
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:05:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5256260
            Orig. end                         :: 5267524
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP113837.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11264
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="16"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11264
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11264
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6264](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6264)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            941..2344
                     /gene="hemG"
                     /locus_tag="OU787_RS23845"
                     /old_locus_tag="OU787_23845"
     CDS             941..2344
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138585.1"
                     /locus_tag="OU787_RS23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_23845"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_268660479.1"
                     /sec_met_domain="DAO (E-value: 1.1e-08, bitscore: 33.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKPHVVVVGGGIAGLAAAAFLGDAAARVTVLEASARFGGKLRGG
                     EVGGVRVDLGAESMLARRPEAVELARRVGLGEQLEPPTTAKAAIWTREGLRPLPGGQLM
                     GVPGDLDALEASGVLTPAGLERARREQPAELGEDAPIGRYIADRLGREVVDRLVEPLLG
                     GVYAGHADEISIRAAVPQLLQLAQQGGELTASIRELSRRATATGPVFQGLRGGLGTLPE
                     AVAAHDRAHGADLRTGHRVDALRRTPDGWLVTTAGRELAADAVVLAVPAPQAAALLAAD
                     APGAAAELRAVEYASMALVTLAFRRADLADSPLTGSGFLVPPVDRRSIKASTFSSNKWG
                     WLERSAPDTFLLRTSLGRHREDAALDLDDADLVARSLADLRTAVGLRATPYDHAVTRWR
                     AGLPQYPVGHLDRVARIRAHLDALGAIAVCGAAYDGVGIPAVIAGARRAAEHLTPGTGT
                     TRTEGTMGS"
     gene            2341..3051
                     /gene="hemQ"
                     /locus_tag="OU787_RS23850"
                     /old_locus_tag="OU787_23850"
     CDS             2341..3051
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138586.1"
                     /locus_tag="OU787_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_23850"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_030459675.1"
                     /transl_table=11
                     /translation="MTESTEQPVKKKARDLNQVIRYTMWSVFKLKDALPEDRTALAAEV
                     DSLFEQLAAKDVVVRGTYDVSALRADADILVWWHAEDSDDLQEAYNRFRRTGLGRHLEP
                     VWSNMALHRPAEFNKSHIPAFLADERPREYVCVYPFVRSYEWYLLPDEERRAMLAEHGM
                     MARGYPDVRANTVASFALGDYEWLLAFEADELHRIVDLMRDLRPSRARLHVREEVPFFT
                     GRRKPVAELLSGLY"
     gene            complement(3085..3840)
                     /locus_tag="OU787_RS23855"
                     /old_locus_tag="OU787_23855"
     CDS             complement(3085..3840)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890185.1"
                     /locus_tag="OU787_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_23855"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_030459674.1"
                     /transl_table=11
                     /translation="MWVLLLIPSCAAAVLSCLRLVRVAAIADACTGRVPHPLHRASGVG
                     LYETAYLAGGPARVVDLALVRMAALGRLHLAHTGWTTVVDPQGRGRLERALIGAIGPDG
                     QCRTAQLKAALAAHPTVRDIGDRLAQAGLATPAVVRDHALRAIRQVRWALAGAASMLLL
                     TVLLTAPDGTAARTAVAWYALPLVLTGGTLLMARVDVHAYTAWAAPAGQTLLRALPCRH
                     TATDDLLTAVAISGPAAVPDPRLRAALGS"
     misc_feature    complement(3845..3860)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.38"
                     /tool="antismash"
     gene            complement(3921..4967)
                     /locus_tag="OU787_RS23860"
                     /old_locus_tag="OU787_23860"
     CDS             complement(3921..4967)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="OU787_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_23860"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_268660480.1"
                     /transl_table=11
                     /translation="MWNFRFVLAFALVVCSIAVAAAFNRRSTRVTDPRGLPGRGLPLLE
                     VAFLAGGPGRVVDTALVRMEREGRVVVSRAHRVTVTTDRTTDPVERVLITAVGGRAGRD
                     LSVLRTSVPGSPEVQRIGDGLAARGLLRHPGALKAAWRARRLVVLALVVTLVLGAVSTA
                     QWLDAPDRDSTAPPFFPFGVLALFTLISLVATRPAKRRITPAGLRQLQLVRGSTPWRPR
                     EVERAHAELVGAFALDGTAALKGSDQQALREALGGGTAPAGRLVKSGRSGRNSDSGSSD
                     FAAGAGAGVWCGSSPSSSCGSSGGHSGGSSHHSCGGSSSHSCGGSSHSCGSSSSCGSSC
                     GGGGCGGS"
     gene            complement(5001..6264)
                     /locus_tag="OU787_RS23865"
                     /old_locus_tag="OU787_23865"
                     /pseudo=""
     CDS             complement(5001..6264)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063323.1"
                     /locus_tag="OU787_RS23865"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="OU787_23865"
                     /product="DUF692 domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 1.9e-87, bitscore: 291.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRLGTGLGWRPEIDTAVERLPGLDWVEVVAENVCAEHLPPSLAE
                     LRSRGVTVVPHGVSLGLGDAAEPDPARLARLAGVAEALGSPLVSEHLAFVRAGGLEAGH
                     LLPVPRTRAALRVVVANVRIAQRELPVPLALENIAAHLAWPGDELTEAQFLAELVERTG
                     VRLLVDVANLHTNRVNLGVDPAAELDRLPLEALAYVHVAGGVERDGVWHDTHTHPVTAP
                     VLEVLAALCERTDPPGVLLERDGAYPPPAELSAELDAIRRVQRLHRREAARV"
     misc_feature    complement(6472..6486)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.01"
                     /tool="antismash"
     gene            6477..7397
                     /locus_tag="OU787_RS23870"
                     /old_locus_tag="OU787_23870"
     CDS             6477..7397
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515442.1"
                     /locus_tag="OU787_RS23870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_23870"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_030459672.1"
                     /transl_table=11
                     /translation="MTSTPYRIRPFASADAPGAAEAYRAGRPHLVTTPEVVAWQAALPH
                     YHLLVAERAGQVVGTARFGPVTESTTPDQGFLNVSVLPEHRGAGIGTALLAAAERDLAA
                     LGTRDAHGWADDTPEALGFAAARGYRRSGRAGRFSGLDLTAPLRPLPPTPPGVELRTAA
                     DFLDDPYPIYLVDIDGARAEPGDLVLDDQPYEGWLAEIWQRPDQDHTLTAVVLADGEPV
                     AFSAAQTDGRRTYWSSFTATRSTHRGRGLAKLAKAHSLHRAKARGLTAAYTQNDEGNAP
                     MLAINDWFGYRACAAEWKHTKALGG"
     gene            complement(7453..9540)
                     /locus_tag="OU787_RS23875"
                     /old_locus_tag="OU787_23875"
     CDS             complement(7453..9540)
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF014404.4"
                     /locus_tag="OU787_RS23875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_23875"
                     /product="restriction endonuclease"
                     /protein_id="WP_268660481.1"
                     /transl_table=11
                     /translation="MWSVLAEAQREQHRRAEAQRRAAEARQREGERARREAQRAAARGE
                     REALKAYQQGRESDAVRRSAELDERVAELRGVLAAGLAGPGFSLVAGGRPAVPPFDPGP
                     LGVPVPMPDQNWYLVPPPAGPQAYHPGARRQWEEQSAQARARFEHDWQAAWAAEQQRQH
                     QLADYRAQYDAWAVERHRLLAGQTTQAGRLAARLRAGEAAAVAEYFEAVVDWREDWPDG
                     FPADGEAVWDAAARRLVVRWELPPYEVVPALSRYRYVRSDDREDEVARPVGQRRELYRE
                     VLAQCALRVLAEVFRADAGGLLASVGLNGVVVATDPATGQEGERCLLAVEVGREVFAGL
                     ALDRVDPLECLVGALGGRIAARPEKGGTVAEVPTTVEPAPVPVPVLVVDGEGPDLFEMD
                     PLEFEELIAELFRRRGLRTSTTARSGDEGVDVLAEDPDPITGGKIVIQAKRYRKTVPPS
                     AVRDLESTMRRQGANRGILVTTAGFGPGSRKHAEGQPLTLVDGPMLLALLREHGLPGRL
                     GPAPSAPVRPAVPAVELVPGQNLVLPDGEVKVRFRSGGAAADLTLLLLDAGGRVRHDRD
                     FVFYHQPAAEGGAVTLRPDERTATVRTAQLPDAVRRVAIAVNLDADGDGTCADLVDPAV
                     ELASGGGRWLFRPPADPAVSAMLVAEVYRHPADGWKLRAVGQGWSDGLAGLARAHGVDV
                     A"
     gene            complement(9637..10041)
                     /gene="msrB"
                     /locus_tag="OU787_RS23880"
                     /old_locus_tag="OU787_23880"
     CDS             complement(9637..10041)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138594.1"
                     /locus_tag="OU787_RS23880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_23880"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_030459670.1"
                     /transl_table=11
                     /translation="MSYEVQKSDAEWRAELTPEEYHVLREAGTERPFVGEYTDTKTVGV
                     YSCRACGAELFSSETKFDSHCGWPSYYAPLAGDSVEYLEDSSLGMRRVEVRCKKCGSHL
                     GHVFEGEGYDTPTDQRYCINSISLTLKPAE"
     misc_feature    complement(10301..10319)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.03"
                     /tool="antismash"
ORIGIN
        1 ctccttcggc tcgacgtgga cgggctgacg ggtcaccagc tccagggtca cggtggagag
       61 cgaggtgcgg gcggtgagct gctgctgctg gcgctgcagg gactccaggt cggactcccg
      121 gcgggtcagc tcgccctcca gcgacaccac ctcggacagg ctcttcgcgt cggccatcag
      181 cgcccgcacc cggtccacgc tggcctgcat ggacttgacc cggctgtcgg tgtcggcgat
      241 ctgctgggtg aggtcgtcgg cctggctgct caggcccagc cgggtgccga gcccgccgag
      301 cccgtccagg gtggcctggt aggccgcgga cgggaccttg agggtcagcg tggactgcgc
      361 ggtgtcgccc gtcccgccgc gcaggttctc cgcggcgacg tacccgccgg cccggacgac
      421 caggtcgacg gccttggtgc gggcgtcgtc gacggcgtcg acccgcagcg tcagcttcgc
      481 ctggtaggcg atctgacggt ccgtcgcggc cgctgttccc gttgtcgccg ccgtcgtccc
      541 cccggagccg gccccggcgg tggccccggc cgagccgggg gcggccccgc ccgagccggg
      601 ggcggccgcc ggcgcgccct gcgtccgggc cgggcccttc gcgtcggcgg cggccgccga
      661 gcccgacgag cgctccccgt ccgcgctgca cccggccagc agcaggaccg cggccagtgc
      721 cccggccgcg cccgctctgc gtacccgcag gtccattcgg taccctcccc gtgttccggg
      781 gcgcgccgtc cgcccgcccc cacggcactg tgacgcggcg gcccccggac cggacccgca
      841 ccggcggtac cggaacgatc acgctgcgga ctcaccccgg tctcggggcg ccccggggcc
      901 gattccggcg aatcggataa gggctgggag actggtcggc atggcgaaac ctcacgtcgt
      961 ggtggtcggt ggcggcatcg cgggcctggc cgcggccgcg ttcctcgggg acgcggcggc
     1021 gcgggtgacg gtgctggagg cgtcggcgcg gttcggcggg aagctgcgcg gcggcgaggt
     1081 cggcggcgtc cgggtcgacc tcggcgccga gtcgatgctc gcccgccgcc ccgaagcggt
     1141 cgaactggcc cgccgggtcg gcctcggcga gcagctcgaa ccgcccacca ccgccaaggc
     1201 cgcgatctgg acccgggagg gcctgcgccc gctgcccggc ggccaactca tgggcgtgcc
     1261 gggagacctg gacgcgctgg aagcctccgg cgtgctcacc cccgcgggcc tggaacgggc
     1321 ccgccgcgag cagcccgccg aactcggcga ggacgccccg atcggccgct acatcgccga
     1381 ccggctcggc cgcgaggtcg tcgaccggct ggtcgaaccg ctgctcggcg gcgtctacgc
     1441 cgggcacgcc gacgagatct cgatccgcgc cgccgttccg cagctgctcc aactcgccca
     1501 gcagggcggc gagttgaccg catccatccg cgagctcagt cgccgcgcca ccgccaccgg
     1561 gccggtcttc cagggcctgc gcggcggact cggcaccctc cccgaagccg tcgccgccca
     1621 cgaccgcgcg cacggcgccg acctgcgcac cggccaccgg gtcgacgccc tgcgccgcac
     1681 ccccgacggc tggctggtca ccaccgccgg acgcgaactc gccgccgacg ccgtcgtgct
     1741 ggccgtcccc gccccgcagg ccgccgcact gctcgccgcc gacgcccccg gcgccgccgc
     1801 cgaactgcgc gccgtcgagt acgcgtccat ggccctggtc accctggcct tccggcgcgc
     1861 cgacctcgcc gacagcccgc tcaccggcag cggcttcctc gtcccgccgg tcgaccggcg
     1921 cagcatcaag gcgtccacct tctccagcaa caagtggggc tggctggagc gctccgcccc
     1981 cgacaccttc ctgctgcgca cctcgctcgg ccgccaccgc gaggacgccg ccctcgacct
     2041 ggacgacgcc gacctggtcg cccgctcgct cgccgacctg cgcaccgccg tcggcctgcg
     2101 cgccaccccg tacgaccacg ccgtcacccg ttggcgggcc gggctcccgc agtacccggt
     2161 cggccacctc gaccgggtcg cccggatccg cgcccacctc gacgcgctcg gcgcgatcgc
     2221 cgtctgcggc gccgcgtacg acggcgtcgg catccccgcc gtcatcgccg gcgcccggcg
     2281 cgccgccgag cacctcaccc ccggcaccgg caccacccgc acagaaggga caatgggctc
     2341 atgaccgaaa gcactgagca gcccgtgaag aagaaggccc gcgacctcaa ccaggtcatc
     2401 cgctacacca tgtggtcggt gttcaagctg aaggacgccc tccccgagga ccgcaccgcg
     2461 ctcgccgccg aggtcgactc cctcttcgag cagctcgccg ccaaggacgt cgtcgtccgc
     2521 ggcacctacg acgtctccgc cctgcgcgcc gacgccgaca tcctggtctg gtggcacgcc
     2581 gaggactccg acgacctgca ggaggcgtac aaccgcttcc gccgcaccgg gctcggccgc
     2641 cacctggagc cggtctggtc gaacatggcg ctgcaccgcc ccgccgagtt caacaagtcg
     2701 cacatcccgg cgttcctcgc cgacgagcgg ccccgcgagt acgtctgcgt ctaccccttc
     2761 gtccgctcct acgagtggta cctgctcccc gacgaggagc gccgggcgat gctcgccgag
     2821 cacggcatga tggcccgcgg ctacccggac gtgcgggcca acaccgtggc ctccttcgcc
     2881 ctcggcgact acgagtggct gctggccttc gaggccgacg aactgcaccg gatcgtcgac
     2941 ctgatgcgcg acctgcgccc ctcccgggcc cgcctgcacg tccgcgagga ggtccccttc
     3001 ttcaccggcc gccgcaagcc ggtcgccgaa ctcctctccg gcctgtactg acccccggcc
     3061 gagcccgcgg ccccgtgctc cccgctagga gccgagggcc gcgcgcaggc gcgggtccgg
     3121 gacggcggcg gggccggaga tggcgacggc ggtgagcagg tcgtcggtgg cggtgtggcg
     3181 gcagggcagg gcccgcagca gggtctggcc ggccggggcg gcccacgcgg tgtaggcgtg
     3241 cacgtcgacc cgggccatca ggagggtgcc gccggtgagc accaggggga gcgcgtacca
     3301 ggcgacggcg gtgcgggcgg cggtgccgtc gggggcggtg agcaggacgg tcagcagcag
     3361 catcgaggcc gccccggcca gcgcccagcg gacctgccgg atcgcccgca gggcgtggtc
     3421 gcggaccacg gccggcgtcg ccagccccgc ctgcgccagc cggtcgccga tgtcgcggac
     3481 ggtcgggtgg gcggccagcg cggccttcaa ctgggcggtg cggcactgac cgtccgggcc
     3541 gatcgcgccg atcagcgcgc gctccaggcg gccgcgcccc tgcgggtcga cgacggtggt
     3601 ccagccggtg tgggcgaggt ggaggcggcc gagggcggcc atccggacca gcgccaggtc
     3661 gaccacccgg gccgggccgc cggccaggta cgcggtctcg tagaggccga cgccggaggc
     3721 ccggtggagc gggtgcggga cccggccggt gcaggcgtcc gcgatcgcgg cgacccgcac
     3781 cagccggagg caggagagca ccgcggcggc gcaggacggg atcagcagca acacccacat
     3841 gcttgctgtt ctagtcctgt gcgcgccgga agcggaacgg atacccgcgc cgcgataccg
     3901 aactgtgact cgaggaacgg tcaggacccg ccgcagccgc ccccgccgca actcgacccg
     3961 caggagctgg acgaaccgca ggagtgcgag gaaccgccgc acgagtgcga ggaggaaccc
     4021 ccgcaggagt ggtgcgagga accgcccgag tggccgccgg acgagccgca ggacgaggac
     4081 ggggacgacc cgcaccacac cccggccccg gccccggccg cgaagtccga gctgccgctg
     4141 tcggagttcc gcccgctccg cccgctcttc accagccggc cggccggcgc cgtgccgccg
     4201 ccgagcgcct cgcgcagcgc ctgctggtcg gagcccttca gcgcggcggt gccgtccagg
     4261 gcgaacgcgc cgaccagttc ggcgtgcgcc cgctccacct cccggggccg ccacggggtg
     4321 ctgccgcgga ccagctgcag ctggcgcagg ccggccgggg tgatccggcg cttcgcgggg
     4381 cgggtggcga ccaggctgat cagcgtgaac agggccagca cgccgaacgg gaagaacggc
     4441 ggcgcggtgg agtcccggtc gggcgcgtcc agccactggg cggtggagac cgcgcccagc
     4501 accagcgtga cgaccagcgc cagcaccacc agccgccggg cccgccaggc ggccttcagc
     4561 gcgcccgggt ggcgcagcag gccgcgggcg gcgagcccgt cgccgatccg ctgcacctcg
     4621 gggctgcccg gcaccgaggt gcgcagcacg gacaggtcgc gcccggcccg gccgccgacc
     4681 gcggtgatca ggacccgttc gaccgggtcg gtggtccggt cggtggtgac ggtgacccgg
     4741 tgggcccggg agaccaccac ccggccctcg cgctccatcc ggaccagcgc ggtgtcgacg
     4801 acccggccgg gcccgccggc caggaaggcg acctccagca gcggcaggcc gcgtccgggc
     4861 aggccgcgcg ggtcggtgac ccgggtgctg cgccggttga aggcggcggc gacggcgatc
     4921 gagcacacga cgagcgcgaa cgccaggacg aaccggaagt tccacatccc ccgtggttcc
     4981 cttctgtgcg gtacgggcgg ttacgggtgc gccttggcgg cgcggtcgcg gtgcggcagc
     5041 aggcggctcc accgggaggc ggcggggcgc agcaggcggc gcagcgcggg ccgccagtcg
     5101 gcggcggcgg ggccgctgtc cagggcccac tcggcgaagg cccgggcgtc ggcccggtag
     5161 ccgccggtga gcggccggcc ggcggcgtag cgggcgaacc gcggggcgaa gtccgccccg
     5221 agcaggtcgg gcagttccgg catcaggtgg ccgacggtct cccggcgctt ggcgagcagg
     5281 cccgcggcct ggacgcgcag ctgctcgggg tcgaagccgg ccggggccgg gccgccggcc
     5341 gtcagggcgg ccagcaactc ctcctggcgg cgcgccagtt cgacccgggc gagggcgagt
     5401 tcggcgtcgg cgcggtcgcg gatcaggtat tcgtggtgct cagacacggg cggcttccct
     5461 ccggtgcagg cgctggacgc ggcggatggc gtcgagttcg gcggacagtt cggcgggcgg
     5521 cgggtacgcg ccgtcccgtt ccagcagcac cccgggcggg tcggtccgct cgcagagcgc
     5581 ggccagcacc tccagcacgg gtgcggtgac ggggtgggtg tgggtgtcgt gccagacgcc
     5641 gtcgcgctcg acgccgccgg ccacgtgcac gtaggcgagg gcctccagcg gcagccggtc
     5701 cagctcggcg gccgggtcga cgcccaggtt gacccggttg gtgtgcaggt tggcgacgtc
     5761 caccagcagg cggacgccgg tccgttcgac cagttcggcg aggaactggg cctcggtcag
     5821 ctcgtcgccc ggccaggcca ggtgggcggc gatgttctcc agcgccagcg gcaccggcag
     5881 ctcccgctgg gcgatccgga cgttggccac caccacccgc agcgcggccc gggtgcgcgg
     5941 caccggcagc aggtgcccgg cctccaggcc gcccgcccgg acgaacgcca ggtgctcgct
     6001 gaccagcggc gacccgagcg cctcggccac gcccgccagc cgggccagcc gggccgggtc
     6061 cggttcggcg gcgtccccca gcccgagcga gacgccgtgc gggacgaccg tgaccccgcg
     6121 ggagcgcagt tcggccagcg agggcggcag gtgctcggcg cagacgttct cggccaccac
     6181 ctccacccag tcgaggccgg gcagccgctc caccgcggtg tcgatctcgg ggcgccagcc
     6241 gaggccggtg cccaatcgcg gaatatcgga cgaagacata ttccaccccc tttccgtcgg
     6301 gcctttcgga ccgcccgact ccccgttgcc gagggtgtat ccaccgcgcg ccgatgccaa
     6361 gcgggacacc ggaaactcag agctgaactt gaggtttcgg cttcactgaa cgcacacgcg
     6421 cgcggggggg aaattcagcg gcgcgcggac gaacgactgg ctaacgtgac atgcctatga
     6481 cttccacgcc gtaccgcatc cgcccgttcg catccgccga cgcccccggg gccgccgagg
     6541 cctaccgggc cggccgcccg cacctggtca ccacccccga ggtggtcgcc tggcaggccg
     6601 ccctgccgca ctaccacctg ctggtcgccg agcgggccgg acaggtcgtc ggcaccgccc
     6661 ggttcggccc ggtgaccgag agcaccaccc ccgaccaggg cttcctcaac gtcagcgtgc
     6721 tccccgagca ccgcggcgcg ggcatcggca ccgccctgct cgccgccgcc gaacgggacc
     6781 tcgccgccct gggcacccgg gacgcccacg gctgggccga cgacaccccc gaggcgctcg
     6841 gcttcgccgc cgcccgcggc taccgcagga gcggccgggc cggccgcttc tccggcctcg
     6901 acctcaccgc cccgctgcgc ccgctgccgc ccaccccgcc cggcgtcgaa ctgcgcaccg
     6961 ccgccgactt cctggacgac ccgtacccga tctacctggt cgacatcgac ggcgcccgcg
     7021 ccgaaccggg cgacctggtc ctcgacgacc agccctacga gggctggctc gccgagatct
     7081 ggcagcgccc cgaccaggac cacaccctca ccgcggtggt cctcgcggac ggcgaaccgg
     7141 tcgccttctc cgccgcccag accgacggcc gccgcaccta ctggtcctcc ttcaccgcga
     7201 cccgctccac ccaccgcggc cgcggcctgg ccaagctcgc caaggcccac tcgctgcacc
     7261 gcgccaaggc ccgcggcctc accgccgcgt acacccagaa cgacgagggc aacgccccga
     7321 tgctcgccat caacgactgg ttcggctacc gcgcgtgcgc ggccgagtgg aagcacacca
     7381 aggcgctcgg cgggtagccg cgggcggggc gacagctcgg gggcgcgggg aactgcgcgc
     7441 ggcgggaggc ggctaagcga cgtccacgcc gtgggcgcgg gccaggcccg ccaggccgtc
     7501 ggaccagccc tggccgaccg cgcggagctt ccagccgtcg gccgggtggc ggtagacctc
     7561 ggcgaccagc atcgcggaga ccgccgggtc ggccggcggg cggaacagcc accggccgcc
     7621 gccggaggcg agctccaccg ccgggtcgac caggtccgcg caggtgccgt cgccgtccgc
     7681 gtccaggttg acggcgatcg ccacccgccg taccgcgtcc gggagttgcg cggtgcggac
     7741 ggtcgcggtg cgctcgtccg gacggagcgt cacggcgccg ccctccgcgg cgggctggtg
     7801 gtagaagacg aagtcccggt cgtgccggac ccgcccgccc gcgtcgagca gcagcagcgt
     7861 cagatcggcc gccgcaccac cggaccggaa ccggaccttg acctcgccgt cgggcagcac
     7921 caggttctga cccggcacca actccacggc ggggacggcg ggtcggacgg gcgccgaggg
     7981 ggccggaccc agccggcccg gcaggccgtg ctcgcgcagc agcgcgagca gcatcggacc
     8041 gtccaccagg gtgagcggct ggccctcggc gtgcttgcgg gagccgggac cgaagcccgc
     8101 cgtggtcacc aggatgcccc ggttggcacc ctgccggcgc atggtggact ccaggtcgcg
     8161 gacggcgctc ggcggcacgg tcttccggta gcgcttggcc tggatgacga tcttcccgcc
     8221 ggtgatcggg tccgggtcct cggccagcac gtccacgccc tcgtcaccgc tgcgcgcggt
     8281 ggtgctggtg cgcaggcccc ggcggcggaa cagctcggcg atcagctcct cgaactccag
     8341 cgggtccatc tcgaacaggt ccggcccctc gccgtccacc acgagcaccg ggacgggaac
     8401 gggcgcgggc tcgaccgtgg tcggcacctc ggcgaccgtc ccgcccttct ccggccgggc
     8461 cgcgatccgc ccgccgagcg cgccgaccag gcactccagc gggtccaccc ggtccagcgc
     8521 gaggcccgcg aacacctccc ggccgacctc cacggccagc aggcagcgct ccccctcctg
     8581 tccggtcgcc ggatcggtcg ccaccaccac gccgttcagc cccaccgagg ccagcagccc
     8641 gccggcgtcg gcccggaaca cctccgccag cacccgcagc gcgcactgcg ccagcacctc
     8701 gcggtacagc tcccgccgct gcccgaccgg ccgggccacc tcgtcctccc ggtcgtccga
     8761 ccggacgtac cggtacctcg acagggcggg caccacctcg tacggcggca gctcccagcg
     8821 caccaccagc cgccgggccg cggcgtccca gacggcctcg ccgtcggcgg ggaagccgtc
     8881 cggccagtcc tcgcgccagt cgacgaccgc ctcgaagtac tcggcgaccg ccgccgcctc
     8941 gcccgcccgc agccgggccg ccagccgccc cgcctgcgtg gtctgcccgg ccagcagccg
     9001 gtgccgctcc accgcccacg cgtcgtactg ggcgcggtag tcggcgagct ggtgctgccg
     9061 ctgctgctcg gcggcccagg cggcctgcca gtcgtgctcg aacctggccc gggcctgcgc
     9121 ggactgctcc tcccactgcc ggcgcgcccc cgggtggtac gcctgcggcc cggccggggg
     9181 cggcaccagg taccagttct ggtccggcat cggcaccggc acgcccaacg gccccgggtc
     9241 gaacggcggc accgccggac ggccccccgc gaccagcgag aaccccggcc cggccagccc
     9301 ggccgccagc accccgcgca actcggccac ccgctcgtcc agttcggcac tgcgccggac
     9361 ggcatccgac tcccgcccct gctggtacgc cttcagcgcc tcgcgctcac cccgcgccgc
     9421 cgcccgctgc gcctcccgcc gggcccgctc gccctcccgc tgccgggcct ccgccgcccg
     9481 ccgctgcgcc tccgcccggc ggtgctgctc gcgctgcgcc tccgccagta ccgaccacac
     9541 gccagaacca cgccgccgcg ccacgcccgc cccacccacg tccaagaccg tccggaagaa
     9601 gatccagtct tccacgcggg cgggcgggcc cggaccctac tcggcgggct tcagcgtcag
     9661 cgagatcgag ttgatgcagt agcgctggtc ggtcggggtg tcgtacccct cgccctcgaa
     9721 gacgtgcccg aggtggctgc cgcacttctt gcagcgcacc tcgacccggc gcatgccgag
     9781 actgctgtcc tccaggtact ccaccgagtc gccggccagc ggcgcgtagt acgacggcca
     9841 gccgcagtgg ctgtcgaact tggtctcgct gctgaacagc tcggcgccgc acgcccggca
     9901 gctgtagacg ccgaccgtct tggtgtcggt gtactcgccg acgaacggcc gctcggtacc
     9961 ggcctcgcgg agcacgtggt actcctccgg cgtcagctcg gcgcgccact cggcgtcgga
    10021 cttctggacc tcgtagctca cggcgactct ccagctctcc agctcggaac ggggacgtca
    10081 gacagcaggt gcaacgtccg ccagggcggc cagaatttcc gggcccaggt tcgtgacgtc
    10141 gcccgcgccc atggtcagca ccaggtcgcc gggggcggcc agcgcggcca gcagcgccgg
    10201 ggcggccgcg aagtcgtgct cggcgcggac gtcggcaccg gcccggcggg ccgcgtcgat
    10261 gatcagctcg gcggtgacgc cggggatcgg gtcctcgcgg gccgggtaga tgtccagcac
    10321 caccgaggcg tcggccagcg ccagcgcctg ccccatctcc tcggccagct gctgggtgcg
    10381 cgagaacagg tgcggctgga agaccaccag cacccggccc gggcccgccg cctcccggat
    10441 cgcctccagg tcggcggcca tctcggtcgg gtggtgcgcg taggagtcga tcacctgcac
    10501 gccgcgcgcc tcgcccttga gctgcagccg ccgccgcacc ccggtgtacg cgcccagcgc
    10561 cttcgccagc ccctcggccg ggacgcccag cgcgatgccc gcggcgagcg ccgcgaccgc
    10621 gttgtgcgcg tagtgccggc cgggcaccga gacggtgaag gtcagcggct cgccgcccag
    10681 ttcgaccgtc acctcgctgg tcatgccgcg cgcctcgacc tccagcaccc gcaggtcggc
    10741 gtcggcggcg gcgccgaccg tcaccacgtt caggccctcc cggcccgtca cccggcgggt
    10801 cagctcgcgg gcgccctcgt ggtcggccga gaccaccagg gtgccgccgg gctggatccg
    10861 gccgacgaag gtctcgaagg actcgtagat ctcctcgatc gacgcgtagt tggcgtggtg
    10921 gtccagctcc acgttcagca cgatcgccac ctcgggcgcg tacttgtgga agctgcggtc
    10981 gctctcgtcc gcctccgcga cgaagatctc gcccgccccg tggtgcgcgt tcgaccccgg
    11041 tgcgtccagg tcgccgccga tcgcgtacga gggctccagg cccagctcgc ccaggctgac
    11101 cgcgagcatc gaggtggtcg tggtcttgcc gtgcgtgccc gccaccgcga gcgcccggcg
    11161 cccgcccatc agcgccgcca gcgcgtcgga gcggtgcacc accgggacgc cgcgctcccg
    11221 cgcggccacc agctccgggt tgtcggcgcg gatcgcgctg gaga
//
