LOCUS       NZ_CP113837            10801 bp    DNA     linear   CON 26-JAN-2024
DEFINITION  Kitasatospora sp. YST-16 chromosome, complete genome.
ACCESSION   NZ_CP113837
VERSION     NZ_CP113837.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora sp. YST-16
  ORGANISM  Kitasatospora sp. YST-16
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 7659304)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-NOV-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 95.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/24/2024 04:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,903
            CDSs (total)                      :: 6,801
            Genes (coding)                    :: 6,649
            CDSs (with protein)               :: 6,649
            Genes (RNA)                       :: 102
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 152
            CDSs (without protein)            :: 152
            Pseudo Genes (ambiguous residues) :: 0 of 152
            Pseudo Genes (frameshifted)       :: 59 of 152
            Pseudo Genes (incomplete)         :: 103 of 152
            Pseudo Genes (internal stop)      :: 5 of 152
            Pseudo Genes (multiple problems)  :: 14 of 152
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:05:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1439943
            Orig. end                         :: 1450744
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP113837.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10801
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10801
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10801
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5801](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5801)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            900..2195
                     /locus_tag="OU787_RS06560"
                     /old_locus_tag="OU787_06560"
     CDS             900..2195
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558983.1"
                     /locus_tag="OU787_RS06560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06560"
                     /product="glycosyltransferase family 87 protein"
                     /protein_id="WP_081967159.1"
                     /transl_table=11
                     /translation="MVAQAPAPAPAPAPTPAPALRPPDRPVRWTRPADWPREVLALAAY
                     WIAGRVLMVGLIRSGRTEPAIEVHRLYHGWYQVLRTGTFPVGDVTWQYPPGAALPMLAP
                     GLLPFLTYLQSFVLLSLLADAAVQAALLAAGRGPGRSTWGAWAWALALPLLLGLPYGRY
                     DLSATALAVGALLLFPARPRLGGVLAGIGAMVKVWPALTLLGTPRGRTTRQAWTAAALS
                     ALALLLVLAACFDHTLGFLHAQGGRGVEIESLGGSALQAARQLGWSGRVEQHYGSFEFL
                     GRYVHRIAQLSLLLTAAAFGWLLLWRVRARRWTAATPYDAALTAVLLFTVTSRVISPQY
                     LVWLIGLAAVCLTVEDTTQRPVALLLLPVVGVTTVDYPLFFDAMQAGGWWPTAVILLRN
                     GLLLGASLWSAARLWRATASPRPAGTGGVSAV"
     gene            2225..2611
                     /locus_tag="OU787_RS06565"
                     /old_locus_tag="OU787_06565"
     CDS             2225..2611
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135059.1"
                     /locus_tag="OU787_RS06565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06565"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_030462458.1"
                     /transl_table=11
                     /translation="MADTALDRLAAGKYLLITSYKKDGSPVATPVWVVRDGDALGVWTV
                     ADSWKVKRIRRRGDVLVGPCDVRGNPSGSPLPATAEIADPATTERYRQLLGRKYGLVGR
                     LTLLGSRLRRGKDGTVGITVRLDG"
     gene            complement(2645..3427)
                     /locus_tag="OU787_RS06570"
                     /old_locus_tag="OU787_06570"
     CDS             complement(2645..3427)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135060.1"
                     /locus_tag="OU787_RS06570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06570"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_081967160.1"
                     /transl_table=11
                     /translation="MRQYRAMVAVGDSFTEGMCDDTLPDGQFRGWADRVADALAAEAGA
                     DGFRYANLAVRGKLIGQIRAEQVDLAAATDADLVTLAGGLNDVLRPGCEVAEVERLLGE
                     CTRELLAEGRTVVLFTSTDPTRRMAGSSRLLPAILRMKAFVEGVVREHPDGVVLVDLFS
                     APVFDDRRLWAEDRLHLSPEGHRRVALAVLEALGRPSAEDWRAPLAEPDTRTRGRKARE
                     DVRWLGTHVGPWIGRRLRGRSSGDGRPAKRPELLPYEG"
     gene            complement(3464..4798)
                     /locus_tag="OU787_RS06575"
                     /old_locus_tag="OU787_06575"
     CDS             complement(3464..4798)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135063.1"
                     /locus_tag="OU787_RS06575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06575"
                     /product="cytochrome P450"
                     /protein_id="WP_081967161.1"
                     /sec_met_domain="p450 (E-value: 2.2e-17, bitscore: 61.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDSSVTGCPFLDPAGAALHAEAAELREQGPAVWVELPGGVRAWS
                     VTRHAVIQALTTDPRVSRDFRLHWPGAAEVPEGWVLGPVAFQDSFVNQYGAEHRAARNR
                     LAPTFLPRRVERMRPQVQATADRLVAAMAELAPGERADLRLALSRPLTLTVICDLFGVP
                     EDLRGALCEAIDTVLDSSLDEDRALAAQVELDVRLRELLARKRTDPAADLTSDLLLSDR
                     PGERPLSEPELVGTLFTMITGGFETAVNLITSAALELLTHPAELARVRTGGLGWADVIE
                     ETLRVEGPVMHVPLRYAVEDLDLGEGVLIRKGDPIILGFAAAGRDPRVHPERPDAFDPG
                     RPDKSHLAFGHGPHFCVGAPLARLEAEIALSTLFARLPALALAEPDRTPARLPSMIVNG
                     PATLDVVPRPLPAPDRRARHRPHPCLDPRPPVSPLPRPRPRRAAR"
     gene            complement(5001..5801)
                     /locus_tag="OU787_RS06580"
                     /old_locus_tag="OU787_06580"
     CDS             complement(5001..5801)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955648.1"
                     /locus_tag="OU787_RS06580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06580"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_030462461.1"
                     /sec_met_domain="Linocin_M18 (E-value: 4e-94, bitscore:
                     313.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLHRDLAPVSAAAWDEIEEEARRTFRLHVAGRRVVDLAGPDGP
                     GLAAVGTGHLADIAAPGSGVQARARESLQVVELRVPFTVTRAAVDDVERGSQDSDWDPV
                     KDAARTIALAEDRAVFDGYPAAGITGIRDGSSNHPVELPADVREYPNAVSRALTALRLA
                     GVGGPYSLLLGADAFTAVNETSDHGYPVHNHLARLLDGEIIWAPAVEGAVLLSARGGDF
                     ELHLGEDLSIGYLSHDETTVHLYLQESLTFQLHTPEAAVALGSI"
     gene            complement(5798..6817)
                     /locus_tag="OU787_RS06585"
                     /old_locus_tag="OU787_06585"
     CDS             complement(5798..6817)
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432629.1"
                     /locus_tag="OU787_RS06585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06585"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_030462462.1"
                     /transl_table=11
                     /translation="MPQPQPVLAALTGAAVFLVLGIEDGGEQTVRDLLPDLGGLARSVG
                     SRAPHEEVGLVVGIGSDAWDRLFAGPRPAGLHPFVELAGPRHLAPATPGDLLLHIRAER
                     MDLCFELATRISQRLGDRVTVLDETHGFRYFDCRDLIGFVDGTENPTGRDAAEAVLIGD
                     EDPDFAGGSYVIVQKYLHDMAGWNAISTEHQERVIGRTKLDNIELDDAAKPADSHVALN
                     TVTGPDGEDRDIWRLNMPFGSFAEGGECGTYFIGYARDPGVTEEMLRNMFLGRGAAAHD
                     RLLDFSTAVTGTFFHVPSADFLNDPPPAPGTRAEARAVPLPVRDGSLRIGSLKRSTTS"
     gene            complement(6957..7442)
                     /locus_tag="OU787_RS06590"
                     /old_locus_tag="OU787_06590"
     CDS             complement(6957..7442)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135066.1"
                     /locus_tag="OU787_RS06590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06590"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_051817389.1"
                     /transl_table=11
                     /translation="MVGAVEERVVEQREFGRLLQGLASEMNLLGHDFAAASGLHATDVQ
                     ALLAVLRAADPPGITPGGLRAELGLTSGAVTAVLDRLERAGHVHRTKDEADRRQVHVHY
                     HPDAARIAGEWFAPVAECTDRVRAEFAPEQVDTVVRFLTRMTAELAELRQVRRAERA"
     gene            complement(7737..8708)
                     /locus_tag="OU787_RS06595"
                     /old_locus_tag="OU787_06595"
     CDS             complement(7737..8708)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135067.1"
                     /locus_tag="OU787_RS06595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_06595"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_030461499.1"
                     /transl_table=11
                     /translation="MSELPPEAGASTGAVARRLGVSPTTVRSWERRYGIGPAERPAGRH
                     RRWTARDVAVLEAMCRLTAHGVPPAEAARLAPAQVEQAEQAEQAERGERAVPVERAAPP
                     GAVPPEVRGLARAARRLDGPEVARLLRDGIERFGAVTAWTDLMAPALRAAGRRWARDGG
                     EQDVEVEHLLSWHVSSALRRVAVPPAGAAGPPVLLAAMPGEQHTLPVEAVAAALAERGL
                     PFRVFGAALPAAALAAAVRRTGPAAVLLWSQTRATADPVPARAVATTPWGPRGARLRPT
                     VLAAGPGWHRTTRPPGTLAPRDLPDTLTLLARALDADGPDGR"
     misc_feature    complement(8752..8766)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.69"
                     /tool="antismash"
     misc_feature    8762..8776
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.07"
                     /tool="antismash"
     misc_feature    complement(9428..9443)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    complement(9451..9462)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: weak, score: 17.94"
                     /tool="antismash"
ORIGIN
        1 ccggtgcgag ggcagcttgg tgtacggctc ggcgaagtcg aagtagtcgg cgaacttggc
       61 gccgtcctgc tccttgccgc cccggacctt ggcgaccagc cggccgcggg tccacatccg
      121 ctcgcgcagc gagccgacca ggtcggcgtc ctcgccgaag cgctcgacca ggatggcccg
      181 ggcgccctcc agcgcggcgg gggcgtcggc gacctgctcg ttcaggtacg tcgcggcgag
      241 cgcggaaggg tcctgggagg ggtcgttcag cagggtgtcg gcgagcggtt cgaggccggc
      301 ctcgcgggcg atctgcgcct tggtgcgccg cttgggcttg tacgggaggt agatgtcctc
      361 cagccgggcc ttggagtcgg cggcgaggat ctgcgcgcgc agcgcgtcgt ccagcttgcc
      421 ctgggcctcg atcgactcca ggacggcggt gcggcgctcc gccagctcgc gcaggtaccg
      481 cagccgctcc tccagggtgc gcagctgggt gtcgtcgagg gcgccggtgg cctccttgcg
      541 gtaccgggcg atgaagggca cggtcgcacc gccgtcgagc aggccgacgg cggcctgcac
      601 ctggttctcg cggacgccga gttcttcggc gatcttgcgt tcgacgggca tggtcacggt
      661 gccggtcacc ccttcagacg gttgcgcggt gtcgcccgtg cattctggca ggtccggccg
      721 acgttcatcc ggtggtccgg tcggccgccc ggagcgtggc gcgttccggg gacgcgggcg
      781 gacacgcgtc cgagcggccc ggaggccggt cggatcgtct ggtatgagag gtggacgacc
      841 gttttccggg ctcccgtcgg cgccgctgcc ggagctgccg tccgcgcgca ttggaggaca
      901 tggtggcgca ggcccccgcc ccggcaccgg cccccgcacc gaccccggca ccggccctgc
      961 ggccgcccga ccggccggtc cgctggaccc gccccgccga ctggccccgc gaggtgctgg
     1021 ccctcgccgc gtactggatc gccggccggg tgctgatggt cgggctgatc cgctccggcc
     1081 ggaccgagcc cgccatcgag gtgcaccggc tctaccacgg ctggtaccag gtcctgcgca
     1141 ccggcacctt cccggtcggc gacgtcacct ggcagtaccc gcccggcgcg gcgctgccga
     1201 tgctcgcccc gggcctgctg ccgttcctga cgtacctgca gtccttcgtg ctgctgtccc
     1261 tgctggccga cgccgccgtg caggccgccc tgctggcggc cggccgcggc ccggggcgct
     1321 cgacctgggg ggcctgggcg tgggcgctgg ccctgccgct gctgctcggc ctgccgtacg
     1381 ggcgctacga cctgtcggcg accgcgctcg cggtcggcgc gctgctgctg ttcccggccc
     1441 ggccgcggct gggcggggtg ctggccggga tcggcgcgat ggtcaaggtc tggcccgcgc
     1501 tgacgctgct cggcaccccg cgcggccgca ccacccggca ggcctggacg gccgccgcgc
     1561 tctccgcgct cgccctgctg ctggtcctcg ccgcctgctt cgaccacacc ctcggcttcc
     1621 tgcacgccca gggcgggcgc ggcgtggaga tcgagtcgct gggcggcagc gccctgcagg
     1681 cggcccggca gctcggctgg tccggccggg tcgagcagca ctacggctcg ttcgagttcc
     1741 tcggccggta cgtgcaccgg atcgcccagc tgtcgctgct gctgaccgcc gcggccttcg
     1801 gctggctgct gctgtggcgg gtccgggccc ggcgctggac ggccgccacc ccgtacgacg
     1861 cggcgctgac cgcggtgctg ctgttcaccg tcaccagccg ggtgatctcc ccgcagtacc
     1921 tggtctggct gatcggcctg gccgccgtct gcctgaccgt ggaggacacc acgcagcggc
     1981 cggtcgccct gctgctgctg cccgtggtcg gcgtcaccac cgtcgactac ccgctgttct
     2041 tcgacgcgat gcaggccggc ggctggtggc cgaccgcggt catcctgctc cgcaacgggc
     2101 tgctgctggg cgcatcgctc tggtccgccg cccggctgtg gcgggccacc gcctcgcccc
     2161 ggcccgccgg caccggcggc gtctcggcgg tctgacgggc cgtcgggaga cgtagactgc
     2221 cccgatggcc gacaccgcgc tggaccggct cgccgccggg aagtacctgc tgatcaccag
     2281 ttacaagaag gacggcagcc ccgtcgccac cccggtctgg gtggtccggg acggcgacgc
     2341 gctgggggtg tggaccgtcg ccgactcctg gaaggtcaag cggatccggc gccgcggcga
     2401 cgtcctggtc ggaccgtgcg acgtgcgcgg caacccgagc ggctccccgc tgcccgccac
     2461 cgccgagatc gccgaccccg ccaccaccga gcgctaccgg cagttgctcg gccgcaagta
     2521 cgggctggtc gggcggctca ccctgctcgg cagtcggctg cggcgcggca aggacggcac
     2581 cgtcggcatc accgtccggc tggacggctg acggctgccg gcggtcactg gcggccgccg
     2641 gcgttcagcc ctcgtacggc agcagctccg ggcgcttcgc cgggcggccg tccccggagg
     2701 agcggccgcg caggcggcgg ccgatccacg ggccgacgtg ggtgcccagc cagcggacgt
     2761 cctcgcgggc cttccggccg cgggtgcggg tgtccggctc ggccagcggg gcccgccagt
     2821 cctcggcgga cgggcggccg agcgcctcca ggaccgccag cgcgacccgg cggtggccct
     2881 ccggggacag gtgcagccgg tcctcggccc agagccggcg gtcgtcgaac accggcgccg
     2941 agaacaggtc caccagcacc accccgtccg ggtgctcccg gaccacgccc tccacgaacg
     3001 ccttcatccg caggatcgcg ggcagcaggc ggctgctgcc cgccatccgc cgggtcggat
     3061 cggtggaggt gaacagcacc acggtgcggc cctcggccag cagttcgcgg gtgcactcgc
     3121 cgagcagccg ctcgacctcg gccacctcgc agcccgggcg cagcacgtcg ttcaggccgc
     3181 ccgccagcgt caccaggtcg gcgtcggtgg ccgcggccag gtcgacctgc tcggcccgga
     3241 tctgaccgat cagcttgccc cgcaccgcca ggttcgcgta ccggaagccg tccgcccccg
     3301 cctcggcggc cagcgcgtcg gcgacccggt ccgcccagcc gcggaactgc ccgtcgggca
     3361 gggtgtcgtc gcacatcccc tcggtgaacg agtcccccac cgccaccatc gcccggtact
     3421 gccgcacacc gcctcctgga gtcgtccctg gccgggcccc accctaccga gcggcccgcc
     3481 gggggcgggg gcgcgggagg ggagagacgg ggggacgggg gtcgagacag ggatgcggtc
     3541 ggtggcgggc ccggcggtcg ggggcgggga gcgggcgggg caccacgtcc agggtggccg
     3601 ggccgttgac gatcatcgag gggaggcggg cgggtgtccg gtcgggttcg gccagggcca
     3661 gggcgggcag ccgggcgaac agggtgctga gcgcgatctc cgcctccagc cgggcgagcg
     3721 gggcgccgac gcagaagtgc gggccgtggc cgaacgccag gtggctcttg tcggggcggc
     3781 ccgggtcgaa cgcgtccggg cgctccgggt gcacccgcgg gtcccggccg gcggcggcga
     3841 agccgaggat gatcgggtcg cccttgcgga tcagcacgcc ctcgccgagg tcgaggtcct
     3901 cgaccgcgta gcgcagcggg acgtgcatca ccgggccctc gacccgcagg gtctcctcga
     3961 tcacgtccgc ccagccgagc ccgcccgtcc gcaccctggc caactcggcg gggtgggtga
     4021 gcagttcgag ggccgcgctg gtgatcaggt tgacggcggt ctcgaacccg ccggtgatca
     4081 tcgtgaacag ggtgccgacc aactcgggct cggacagcgg ccgttcgccg gggcggtcgg
     4141 acagcagcag gtcgctggtc aggtcggccg ccgggtcggt ccgcttgcgt gccagcaact
     4201 cccgcagccg gacgtcgagt tcgacttgcg cggcgagtgc gcggtcctcg tcgagcgagg
     4261 agtccagcac ggtgtcgatc gcctcgcaga gtgcgccgcg caggtcctcc gggacgccga
     4321 acaggtcgca gatcaccgtc agggtgagcg gccgggacag tgccagccgc aggtccgcgc
     4381 gctccccggg ggccagttcg gccatggctg ccaccagccg gtccgccgtg gcctgcacct
     4441 gcgggcgcat ccgctccacc cggcgcggca ggaaggtcgg cgcgagccgg ttccgcgcgg
     4501 cgcggtgctc ggccccgtac tggttgacga agctgtcctg gaacgccacc ggccccagca
     4561 cccagccctc cggcacctcc gccgcccccg gccagtgcag ccggaagtcc cgggagaccc
     4621 gcgggtcggt ggtcagcgcc tggatcaccg cgtgccgggt caccgaccag gcccgcaccc
     4681 cgcccggcag ttccacccac accgccgggc cctgctcgcg cagctccgcg gcctccgcgt
     4741 gcagcgcggc cccggccggg tcgaggaacg ggcagccggt aacggaagaa tcggacacgg
     4801 tgtgctcccc tcaccgaaag tccccgtact gcccccatgg tggggcccgc cgcgccaccg
     4861 ccggaagact ccgcgcagct ctgtccggat tgcgcccccg gtaccgtcaa ctccccttcc
     4921 accagcacct gttgacacca ggaaccccac ccgcgccgga cgcgcgggtg gggttcctgg
     4981 gccctgttgc tgacgggccg tcagatcgag ccgagggcga ccgcggcctc cggggtgtgc
     5041 agctggaagg tcagggactc ctggaggtag aggtgcacgg tggtctcgtc gtgggagagg
     5101 tagccgatcg agaggtcctc gcccaggtgc agctcgaagt cgccgccgcg ggcggacagc
     5161 aggacggcgc cctcgaccgc cggggcccag atgatctcgc cgtccagcag gcgggccagg
     5221 tggttgtgga ccgggtagcc gtggtcggag gtctcgttga cggcggtgaa ggcgtccgcg
     5281 ccgagcagca gcgagtaggg gccgccgacc ccggccaggc gcagcgcggt gagggcccgg
     5341 ctgacggcgt tggggtactc gcggacgtcg gcgggcagtt cgaccgggtg gttggaggag
     5401 ccgtcccgga tgccggtgat cccggcggcc gggtagccgt cgaagaccgc gcggtcctcg
     5461 gcgagcgcga tggtgcgggc ggcgtccttg accgggtccc agtcggagtc ctgggagccg
     5521 cgctcgacgt cgtccacggc ggcccgggtg acggtgaacg ggacccgcag ctcgaccacc
     5581 tggagggact cccgggcccg ggcctggacg ccgctgccgg gggccgcgat gtcggccagg
     5641 tgcccggtgc cgaccgcggc cagccccggc ccgtcgggcc cggccaggtc gaccacccgc
     5701 cgcccggcga cgtgcagtcg gaaggtccgc cgggcctcct cctcgatctc gtcccaggcg
     5761 gcggcggaga cgggcgccag gtcgcggtgc aggttgttca cgatgtggtg ctccttttca
     5821 ggctgccgat gcggaggctg ccgtcccgga ccggcagggg cacggcccga gcttcggccc
     5881 gggtgccggg ggcggggggc gggtcgttca ggaagtccgc ggaggggacg tggaagaagg
     5941 tcccggtgac ggcggtggag aagtccagca gccggtcgtg ggcggcggcc ccgcggccca
     6001 ggaacatgtt gcggagcatc tcctcggtga cccccgggtc gcgggcgtac ccgatgaagt
     6061 aggtgccgca ctcgccgccc tcggcgaacg acccgaacgg catgttcagc cgccagatgt
     6121 cgcggtcctc gccgtcgggg ccggtgacgg tgttcagggc gacgtgcgag tcggcgggct
     6181 tggccgcgtc gtccagctcg atgttgtcga gcttggtgcg gccgatcacc cgttcctggt
     6241 gctcggtgct gatcgcgttc caacccgcca tgtcgtgcag gtacttctgc acgatgacgt
     6301 agctgccgcc cgcgaagtcc gggtcctcgt cgccgatcag gaccgcttcg gcggcgtccc
     6361 ggccggtggg gttctcggtg ccgtcgacga agccgatcag gtcccggcag tcgaagtagc
     6421 ggaagccgtg ggtctcgtcc agcacggtga cccggtcgcc gagccgctgg ctgatccggg
     6481 tggccagttc gaagcacagg tccatccgct cggcccggat gtgcagcagc aggtcgccgg
     6541 gggtggcggg ggcgaggtgc cggggtccgg ccagttcgac gaacgggtgc agtccggcgg
     6601 ggcgggggcc cgcgaacagg cggtcccagg cgtcggagcc gatcccgacc accaggccga
     6661 cctcctcgtg cggggcccgg gaaccgaccg agcgggccag cccgccgagg tccggcagca
     6721 ggtcgcggac ggtctgctca ccgccgtcct cgatcccgag caccaggaac acggcggccc
     6781 cggtcagcgc ggcgaggacc ggttggggct gcggcatggc gggggctccc agggggctgc
     6841 cggacgttcg gacgcgagcc gaccataccg ggcaaaaggt tcgagaaccc gtgatggcgc
     6901 ccgaatcggg cgtgtccggc ggaaccgggc cgggaggggt ccgcggcggc cccggctcag
     6961 gcccgttcgg cccgcctgac ctgccgcaac tcggccagct ccgcggtcat ccgggtcagg
     7021 aagcgcacca cggtgtccac ctgttccggc gcgaactcgg cccgcacccg gtccgtgcac
     7081 tccgcgaccg gggcgaacca ctcaccggcg atccgggccg cgtccgggtg gtagtgcacg
     7141 tgcacctgcc gccggtccgc ctcgtccttg gtccggtgca cgtgccccgc ccgctccagg
     7201 cggtccagca ccgcggtcac cgcgcccgag gtgagcccca gttcggcccg cagcccgccg
     7261 ggggtgatgc cgggcggatc ggccgcccgc agcaccgcga gcagcgcctg cacatcggtg
     7321 gcgtgcaggc ccgaggcggc ggcgaagtcg tgccccagca ggttcatctc ggacgccagc
     7381 ccctgcagca gccgcccgaa ctcccgctgc tccaccaccc gctcctccac cgcacccacc
     7441 acccgctgct gcccgaccgt gccgccccga ccctagcgcg agcgcctccg ccggggcacg
     7501 gaggaacggc acggggcggg gagccgggga cgcgtcgggg gcgggagcgc actcagccag
     7561 gccgggccag ggacgggcga gggacgggcc gggcgagggg cgcctcacgg gacgggggcc
     7621 tctgcggccc cgaggcccgg aggcccggaa gcccggaggc cccgggcggg gaacgcgtcg
     7681 ggggcgggag cgcgcccggc ctggagcgtg ctcggccggg aggacggcct ccgcgctcac
     7741 cggccgtccg gcccgtccgc gtccagggcc cgggccagca gggtgagggt gtccgggagg
     7801 tcgcgggggg ccagggtgcc gggcgggcgg gtggtgcggt gccagccggg gccggcggcg
     7861 aggacggtgg ggcggaggcg ggcgccgcgg gggccccagg gggtggtggc gacggcacgg
     7921 gcggggacgg ggtcggcggt ggcgcgggtc tgcgaccaga gcaggacggc ggcggggccg
     7981 gtgcggcgga cggcggcggc gagggccgcc gcgggcagtg cggcgccgaa gacccggaac
     8041 ggcaggccgc gttcggcgag cgccgcggcc accgcctcca ccggcagggt gtgctgctcg
     8101 ccgggcatcg cggccagcag caccggcggc ccggccgcgc ccgccggggg caccgcgacc
     8161 cggcgcagcg cgctggagac gtgccaggac agcaggtgct caacctcgac gtcctgctcg
     8221 ccgccgtcgc gggcccagcg gcgtccggcg gcgcgcagcg cgggcgccat caggtccgtc
     8281 caggcggtga cggcgccgaa ccgttcgatc ccgtcccgca gcagccgggc cacctcgggt
     8341 ccgtccagcc gccgcgcggc ccgggccagc ccgcgcacct cgggaggcac cgcgcccggc
     8401 ggcgccgccc gttcgaccgg caccgcccgc tcgccccgtt cggcctgctc ggcctgttcg
     8461 gcctgttcga cctgcgcggg ggccagccgg gcggcctcgg cgggtggcac cccgtgcgcg
     8521 gtgaggcggc acatcgcctc cagcacggcc acgtcgcggg cggtccagcg ccggtgccgg
     8581 ccggccgggc gctcggccgg gccgatcccg tagcggcgtt cccaggagcg gacggtggtc
     8641 ggcgagaccc cgagccgccg ggcgaccgcc ccggtgctgg cgcccgcctc gggcggcagt
     8701 tctgacatcc cgtcagccta ggccctgccc gggggcgggg ccccgtagcg caaatctctc
     8761 aatcattgag atattctcgc ggccatgtcg acttccgcac cgccctcccc cgcaccgcgc
     8821 ccgaccgcgg cccgccgcct gcggttcctg ctcccgctcg tcctcctgct ggtctggctg
     8881 gtgctcggcg gcgcgctcgg gccgttcgcc gggcggctgg gcgaggtgtc gaccaacgac
     8941 ggggccgcgt tcctgccgcg cagcgccgag tcgacccggg tcgcccggct ggagaaggac
     9001 ttccgcaccg aatcgacgct gccggtggtg ctggtctggg aggcggagtc cgggcaggtg
     9061 gacgacgcgc tgcgggccgg ggcgggccag gcgctggccg cggccgcgca ggtgcccggc
     9121 ggcaccgggc aggtctcgcc gctgctgccg tccgaggacg ggcgggcgct ggaggcggtc
     9181 gtgcagctgc gcgccgacct cgggccggac accaaggagg cggtcgcggc catccgcgac
     9241 gaggccggga aggtcccggg cgccaccgcc ggggtggccg ggcccgcggc ggtgctggcc
     9301 gacctgtcgg gggcgttcgc cggcatcgac ggcctgctgc tcggggtggc gctcggcgtg
     9361 gtgctgctga tcctgctgct ggtgtaccgg gcggtgctgc tgccgctgct ggtgatcctc
     9421 ggcgcggtgt tcgccctcgc cgcggcctgc gcgatcgtgt acgcgctggc gcagcacggc
     9481 gtggtccggg tggacgggca ggtgcagggg ctgctgtcga tcctggtgat cggcgcggcc
     9541 accgactacg ggctgctgct gtccgcccgg ttccgcgagg aactcgccgc cgggcaggac
     9601 cggttcgccg ccgcccgcac cgcgctgcgc cgctcggtgg agccggtcgc cgcctcgggc
     9661 ctcaccgtgg gcctgggcct gctggtgctg ctgctctccg acctgacgaa caaccgggcg
     9721 ctcggcccgg tcggcgcgat cggcatcgcc tgcgcggtgc tgtccgcgct gaccttcctc
     9781 ccggcggcgc tcgcgctgtg cggccgggcc gcgttctggc cggcccggcc cggcaccggc
     9841 ggcggctcga accggctctg gcagcgggtc gccgacctgg tgggccgccg tccgcgcgcg
     9901 ctgtgggtgg gctcggtcgc ggtgctggcg gcactcgcgg cctgctcccc gctgctggac
     9961 gcccggggcg tgccgcagtc cgagctgttc accaccgccc agccctcggt cgccgcccag
    10021 cgcctgctct ccgcgcactt cccgggcggc tccggcaacc cggcggtgat cgtcgccgac
    10081 gccgcgcacg cggacgccgt ggcggccgcc gccgcgcggg tgcccggcgt cgccgcggtc
    10141 cgcccgtaca ccggcggcgc gcccaccgcc ccaccggtgg tcgccgacgg ccgggtccgg
    10201 ctcgacgcga cgctcgccga ccccgccgac agcgacgccg ccctcgccgc cgtcggccgg
    10261 ctgcgcaccg ccgtgcacgc cgtggacggg gcagacgcgc tggtcggcgg ctactcggcg
    10321 cagcaggccg acacccgggc caccgcccgg gacgaccgga cgctgatcat gccggtggtg
    10381 ctgctgtgca tcctggcggt gctgatgctg ctgctgcgct cggtgctggc gccgctgctg
    10441 ctggcggcga cggtcgcgct ctcctacctg gccacgctgg gcgtctcggc gctggtcttc
    10501 ccgcacgtgt tcggcttctc ggcgaccgac ccgtccgtcc cgctgtacgg gttcgtgttc
    10561 ctggtcgcgc tgggcgtgga ctacaacatc ttcctgatga cccgggtccg cgaggagacc
    10621 gccgccctcg gcacccgggc gggcgtgctg cgcggcctca ccgcgaccgg cggcgtcatc
    10681 acctccgcgg gcgcggtcct cgccgcgacc ttcgcggcgc tgggcgtcat cccgctggcc
    10741 ttcctcgccc agatcgcctt catcgtggcc ttcggcgtcc tgctggacac cctgctggtc
    10801 c
//
