LOCUS       NZ_CP113837            22661 bp    DNA     linear   CON 26-JAN-2024
DEFINITION  Kitasatospora sp. YST-16 chromosome, complete genome.
ACCESSION   NZ_CP113837
VERSION     NZ_CP113837.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora sp. YST-16
  ORGANISM  Kitasatospora sp. YST-16
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 7659304)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-NOV-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 95.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/24/2024 04:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,903
            CDSs (total)                      :: 6,801
            Genes (coding)                    :: 6,649
            CDSs (with protein)               :: 6,649
            Genes (RNA)                       :: 102
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 152
            CDSs (without protein)            :: 152
            Pseudo Genes (ambiguous residues) :: 0 of 152
            Pseudo Genes (frameshifted)       :: 59 of 152
            Pseudo Genes (incomplete)         :: 103 of 152
            Pseudo Genes (internal stop)      :: 5 of 152
            Pseudo Genes (multiple problems)  :: 14 of 152
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:05:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 522991
            Orig. end                         :: 545652
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP113837.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22661
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="2"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22661
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22661
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12661](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12661
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    234..249
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.87"
                     /tool="antismash"
     misc_feature    complement(530..539)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(783..797)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 17.93"
                     /tool="antismash"
     misc_feature    867..882
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            complement(1161..2228)
                     /locus_tag="OU787_RS02425"
                     /old_locus_tag="OU787_02425"
     CDS             complement(1161..2228)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (66-333). E-value: 2e-17.
                     Score: 55.6. Matches aSDomain:
                     nrpspksdomains_OU787_RS02425_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536561.1"
                     /locus_tag="OU787_RS02425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02425"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_268658368.1"
                     /sec_met_domain="PF00561 (E-value: 6.9e-13, bitscore: 47.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.8e-10, bitscore:
                     39.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIAAALTAAAAATPVAGLLAHRAAVRAGRARDLRIDTGRGVDES
                     HFAPIGGLDQWISVRGQDRANPVVLELHGGPGSSNAVLAHLSRDWERHVTLVRWDMRGT
                     GKTLRRSGADGQGELTFDRLLRDAVEVIEHVRARLGVTRVVLLGCSFGSALGLRIARSR
                     PDLVSAYVGTDQKIFDGGRDTTDYHDALERLDRAGKKKEAAAVRAAGPDQRAWSAEQFA
                     HFNRFAAATDPYTFAAMKSVVTKSLWYSPLHSLPELGTFFRSFLVSAAVLPGTAALDDH
                     ADGTRFDVPFFLVQGARDLVNTPARARAFYDRVQAPAKSFTLIEEAGHFAVYRRPDLFL
                     DLLRTTVLPALPTTR"
     aSDomain        complement(1230..2030)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_OU787_RS02425_Abhydrolase_1.1"
                     /evalue="2.00E-17"
                     /label="OU787_RS02425_Abhydrolase_1.1"
                     /locus_tag="OU787_RS02425"
                     /protein_end="333"
                     /protein_start="66"
                     /score="55.6"
                     /tool="antismash"
                     /translation="PVVLELHGGPGSSNAVLAHLSRDWERHVTLVRWDMRGTGKTLRRS
                     GADGQGELTFDRLLRDAVEVIEHVRARLGVTRVVLLGCSFGSALGLRIARSRPDLVSAY
                     VGTDQKIFDGGRDTTDYHDALERLDRAGKKKEAAAVRAAGPDQRAWSAEQFAHFNRFAA
                     ATDPYTFAAMKSVVTKSLWYSPLHSLPELGTFFRSFLVSAAVLPGTAALDDHADGTRFD
                     VPFFLVQGARDLVNTPARARAFYDRVQAPAKSFTLIEEAGHFAVY"
     misc_feature    2255..2273
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 16.2"
                     /tool="antismash"
     misc_feature    complement(2278..2296)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 16.49"
                     /tool="antismash"
     misc_feature    2281..2299
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.06"
                     /tool="antismash"
     gene            2390..3142
                     /locus_tag="OU787_RS02430"
                     /old_locus_tag="OU787_02430"
     CDS             2390..3142
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102627.1"
                     /locus_tag="OU787_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02430"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_268658369.1"
                     /transl_table=11
                     /translation="MPANKESQRDPNVSLALLWGEAEERPRRGPRPKFTPAEVARHGVA
                     VADAEGLEALSMQRVAEALGVTTMALYRYVPGKPDLVDLMVDTVLGDPPALDAVPGGWR
                     PRLEVWARACWDVYRAHPWILTATGLRRHAMGPRQVAWLDGALAALEPTGLDARQRHDA
                     AILVLSLVRSLTQESLDRTEEGDREWDRLTADQLARHADRFPALTRAAAAGAFAPAPAP
                     ADPLAFGLACVLDGLQGLVERTAGPDGG"
     gene            3386..4648
                     /locus_tag="OU787_RS02435"
                     /old_locus_tag="OU787_02435"
     CDS             3386..4648
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057621.1"
                     /locus_tag="OU787_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02435"
                     /product="histidine kinase"
                     /protein_id="WP_268661788.1"
                     /transl_table=11
                     /translation="MIRPGLRRPALLARRARRDAGFLATGVLPHLALVPVWAWAATFMA
                     RTGHWKPALEVAVLLIVLGTPLVTAVQRVRHRILLGVDVVPPAPAPEPWSWAVAARQAL
                     SWLTSAQTWRQVGYHLLLGPLLAAAELLVLAAAVAGLAGATAYGWAWSVPARERGGWLE
                     YATQLPWYTLGGLLLLGALPWVAGAAARGESRAAAALLGPSRSQRLQQRVEHLAESRTG
                     LIEAVDAERRRIERDLHDGTQQRLVSLAVNLGLVLATTPDLPDGARAAVAEAHLEAKHA
                     IAELNDLVRGLHPAVLEDRGLDAALSGLAARLPLPVRLRVDLDERVPPGVESVAYFVIS
                     EALANVIKHAGATRTEVTVRQVGSVLRVNVTDDGLGGADPSAGTGLGGLAKRVDAIDGS
                     FHVSSPVGGPTTVTAELPCAR"
     gene            4636..5286
                     /locus_tag="OU787_RS02440"
                     /old_locus_tag="OU787_02440"
     CDS             4636..5286
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057620.1"
                     /locus_tag="OU787_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02440"
                     /product="response regulator transcription factor"
                     /protein_id="WP_268658370.1"
                     /transl_table=11
                     /translation="MRAVIAEDSVLLRVGLVKVLEMGGFQVVAEVDDAPSLLAAVEQHR
                     PELALVDVRMPPSFTDEGVRAALEIRRRRPGTAVVLLSQYVEERYAADLLSADTSGVGY
                     LLKQRVADVTEFVETVRRVAGGGTALDPQVVAQLLLRRSNDPLERLTPRERDVLALMAE
                     GHSNVGIAETLTISESAVAKHINNIFAKLDLPVADSGHRRVLAVLRFLGTSRS"
     gene            5611..6105
                     /locus_tag="OU787_RS02445"
                     /old_locus_tag="OU787_02445"
     CDS             5611..6105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134221.1"
                     /locus_tag="OU787_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02445"
                     /product="tyrosine protein phosphatase"
                     /protein_id="WP_268658371.1"
                     /transl_table=11
                     /translation="MRPTLFTIDRSGPGRISTMARPRGGDWLAEELAALAALGVSELVS
                     ALTPAECAELGLDAEPSLARAAGLRFTAVPIPDRTVPAPSEVLPVLDGLARRLAAGGHL
                     VVHCRAGIGRSSLLAAAVLVRSGADPDDTWARIARARGLTVPDTPEQRAWTARITPPHR
                     P"
     gene            complement(6134..7297)
                     /locus_tag="OU787_RS02450"
                     /old_locus_tag="OU787_02450"
     CDS             complement(6134..7297)
                     /EC_number="2.1.2.3"
                     /GO_function="GO:0003937 - IMP cyclohydrolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004643 -
                     phosphoribosylaminoimidazolecarboxamide formyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF005492.0"
                     /locus_tag="OU787_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02450"
                     /product="phosphoribosylaminoimidazolecarboxamide
                     formyltransferase"
                     /protein_id="WP_268658372.1"
                     /transl_table=11
                     /translation="MDLRYGINPQNTRARIEPLPGTDLPLRLLNGQPSYVNLLDALNAW
                     QLVSEAAALFGRPAAASFKHVSPAGAALAGPVDRAAAEPYGLDPATVGPLTSAYLRARD
                     ADPKSSYGDLVAVSHEVDLELADLLARVVSDGIVAPGYAPGVLDVLARKKNGRYLVLEA
                     RPGCTPPAVETREVHGVRLVQDTDTTPLTAALLADVRVGALTPAAADDLLLGLAVLRRT
                     QSNSVCYLRGGAALGIGAGQQSRVDCTRLAGAKTDTWWLRRHPAVRALDFRPEVRRQDR
                     INWQIRYLKGDLTPDERARFAAALRDGDVPDELGPDERARWAAELDGVAFVSDGCLPFR
                     DNVDHARRHGVTAIAEPGGSLRSAEVETACAEHGITLVRTGLRLFHH"
     regulatory      complement(7335..7424)
                     /bound_moiety="5-aminoimidazole-4-carboxamide
                     ribonucleotide (ZMP)/
                     5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl
                     5'-triphosphate (ZMT)"
                     /db_xref="RFAM:RF01750"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01750"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="ZMP/ZTP riboswitches appear to regulate genes
                     involved in one-carbon metabolism; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(7529..8107)
                     /locus_tag="OU787_RS02455"
                     /old_locus_tag="OU787_02455"
     CDS             complement(7529..8107)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008736887.1"
                     /locus_tag="OU787_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02455"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_030461097.1"
                     /transl_table=11
                     /translation="MRADARKNRDQLLAVAGVVVAEQGADASLRDIARRADVALPTLYR
                     HFPTREALLDALLRESFDGLAERAAALEASDPPEDALVTWLRDCVAVAREYRGVTELMA
                     AAIEDTGSALHASCVTMRAAGTRLLARAQAAGAARADLDGTELFALVAALAWLGDQGSF
                     APRADHLFTVVADAVLAGGTDRGIGAERR"
     gene            8222..9232
                     /locus_tag="OU787_RS02460"
                     /old_locus_tag="OU787_02460"
     CDS             8222..9232
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (22-333). E-value: 7.8e-33.
                     Score: 105.8. Matches aSDomain:
                     nrpspksdomains_OU787_RS02460_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192340.1"
                     /locus_tag="OU787_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02460"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_268658373.1"
                     /sec_met_domain="ADH_N (E-value: 5.6e-09, bitscore: 34.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.4e-15, bitscore:
                     54.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAKTMRAIRLHEFGGPEVLRHDEVPIPRPQPGEVLVRVHAVGLN
                     PPDWYLRDGMPGIPPELRPPVSLPAVPGSDVSGVVAAVAEDVTDFSVGDEVFGMLRFPS
                     FDGRAYAEYVAAPAADLARKPAGVDHVHAAGAAMSGLTAWQYLVELGHDHPNPLQPAQH
                     RPVPLEAGMTVLVNGAAGGVGHLGLQLAKWKGARVIAVASGAHEQFLRELGADEFVDYT
                     KTRPEEAVRDVDLVLDTVGGPGSGRFLRTLRRGGALHFVFIATYDPAEVTRLGVTTSIT
                     QVRSNGRQLGELGRLLDTGTLRVAIDSTFPLADARKAHERAARGHLRGKIVLTAV"
     aSDomain        8288..9220
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_OU787_RS02460_PKS_ER.1"
                     /evalue="7.80E-33"
                     /label="OU787_RS02460_PKS_ER.1"
                     /locus_tag="OU787_RS02460"
                     /protein_end="333"
                     /protein_start="22"
                     /score="105.8"
                     /tool="antismash"
                     /translation="DEVPIPRPQPGEVLVRVHAVGLNPPDWYLRDGMPGIPPELRPPVS
                     LPAVPGSDVSGVVAAVAEDVTDFSVGDEVFGMLRFPSFDGRAYAEYVAAPAADLARKPA
                     GVDHVHAAGAAMSGLTAWQYLVELGHDHPNPLQPAQHRPVPLEAGMTVLVNGAAGGVGH
                     LGLQLAKWKGARVIAVASGAHEQFLRELGADEFVDYTKTRPEEAVRDVDLVLDTVGGPG
                     SGRFLRTLRRGGALHFVFIATYDPAEVTRLGVTTSITQVRSNGRQLGELGRLLDTGTLR
                     VAIDSTFPLADARKAHERAARGHLRGKIVL"
     CDS_motif       8732..8794
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_OU787_RS02460_0001"
                     /evalue="2.70E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="OU787_RS02460"
                     /protein_end="191"
                     /protein_start="170"
                     /score="13.6"
                     /tool="antismash"
                     /translation="GMTVLVNGAAGGVGHLGLQLA"
     misc_feature    9410..9420
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(9542..9556)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.31"
                     /tool="antismash"
     gene            9831..9998
                     /locus_tag="OU787_RS02465"
                     /old_locus_tag="OU787_02465"
     CDS             9831..9998
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134222.1"
                     /locus_tag="OU787_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02465"
                     /product="SflA family class IV lanthipeptide"
                     /protein_id="WP_162870071.1"
                     /transl_table=11
                     /translation="MPVATPTAIRDAGPLAVDDETLVFEDDDRTDHDPTACLSDPWVTA
                     TTRVACDFNS"
     gene            10001..12661
                     /gene="lanL"
                     /locus_tag="OU787_RS02470"
                     /old_locus_tag="OU787_02470"
     CDS             10001..12661
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134223.1"
                     /locus_tag="OU787_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02470"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_268658374.1"
                     /sec_met_domain="Pkinase (E-value: 2.8e-16, bitscore: 58.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-11, bitscore:
                     42.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGSVAVRRPWSDDTWSYLNDPRMPAMEHGWKLHVSARPGTLAAV
                     LALVLPVLERHVCHAKWARDPEVLRTLNSGTRNAASVGKAVTVYPVPGELLPLAAELAD
                     VLRGREGPPITGDRRLAPDAPVYYRYGPFTGDYRTGRSGRLESVMTGPDGQLFDGLAGT
                     AYRCPPWAADPFTRPAAAPPASPAPGAPATPSAADTPTAAAGFGGGRYRVTGGIARKAQ
                     GNVYRALDLVTGLAVVVKQARAYVAEDADGADARDRLRNEHAVLTALDGLPGVPRALDY
                     FRHRADEYLVTTDCGSRDLRREVHDHGPFAAMGTDRPHPSGPLAARLLRVLDGAHRRGV
                     VVRDLKPDNVVLDAEGHCHVVDFGISARHGTGPDGSTPGYSGPVHRPGAPALPADDYHA
                     LGMTLHFAATGLDPVVLDPDPAVNRERTLACLEFAIPGPAHQQFRALIGDLTSPDPATR
                     TAGADRLRREAGQAALQQTSNKAKLTRTGLPRREAERPSRRRPPAAPQIPADLLAEVVE
                     HTVAVCVAEAHRIADPARADRSAVPAPVDVYGGSSGLGLELLQHLHRPGVPAAVAALAD
                     WTARQHRTLPAGLYCGRTGVDLFLTAAGAPPPHTATDLPDQRPGGGPPEADLIDGAAGT
                     GLGHLLLARAHPAPAPAVAAAVTDAPADRHLAAATACRDQLTTGHARLTPAAAPRPGDA
                     ALTRGIAHGDAGVAHFLLAHARATGDPVSRHHAALACARLADATPALLAAATRPGASRR
                     YGSWCRGLAGIGAVLARAAEQLSEPAHRALAERCALACLDLAPRMPLVTQCCGLAGVGD
                     LMLELAPAAPEFHEAAGTVAALVLARSAGPAARPVFPDAGLVRQSFGHATGTPGVLAFL
                     RRLHSPGSPPLGTLP"
     gene            complement(12786..13292)
                     /locus_tag="OU787_RS02475"
                     /old_locus_tag="OU787_02475"
     CDS             complement(12786..13292)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OU787_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="OU787_02475"
                     /product="hypothetical protein"
                     /protein_id="WP_268658375.1"
                     /transl_table=11
                     /translation="MDGHLDGTLVARMREYLAAGTAMDLAALEALYDEEFENVRTDEAG
                     RVAVLTKAHFMARFRALAARGEGVADGGTDDVRFLSAGRRGDQGTVVMYRCEDGLPARY
                     VFVWRWEDGRWTTLLREFTFERDVSPLLALLAAVAAGGNGAGAGAGAGVGSGAGAGAGG
                     AAVEG"
     gene            13494..14963
                     /locus_tag="OU787_RS02480"
                     /old_locus_tag="OU787_02480"
     CDS             13494..14963
                     /EC_number="3.5.1.4"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019055828.1"
                     /locus_tag="OU787_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02480"
                     /product="amidase"
                     /protein_id="WP_268658376.1"
                     /transl_table=11
                     /translation="MTDETWTYATAGELTAALRAGKVSSVELTEEAIGRIEREDGALNA
                     ICAPDFERARDAARAADRARARGEERPLLGVPVTVKESYNVAGLPTTWGMPQFRDHVPA
                     EDALQVARVKAAGAVVLGKTNVPLGLQDIQTYNEIHGTTVNPWDRTRTCGGSSGGSAAA
                     LAAGFGALSLGTDIAGSLRTPAHFCGVYAHKPTLHLLPTRGMVPPHAPALPADIDLAVA
                     GPMARSARDLTLLLDVMAGPDPLTSGLAHTLDLPPARHDRLSDFRVLVLDEHPLIPTGA
                     DVRAGLARVVDALAEGGARIERHSPLLPDLADAAELYTLLLSSAVAVQFPVGSQQQLAA
                     QVAGLSEDDHSLVAARLRGLLLSHRDWLGADRRRELHRHAWRQLFAEFDAVVAPITPTA
                     AFPHDQDPDLMNRRITVDGTAHTYFDQLVWAGLATMPGLPATAVPTGPSAAGLPVGVQL
                     IGPMYEDRTPLRLAELLEERLGGFRPPRALH"
     gene            complement(15018..17021)
                     /locus_tag="OU787_RS02485"
                     /old_locus_tag="OU787_02485"
     CDS             complement(15018..17021)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134228.1"
                     /locus_tag="OU787_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02485"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_268658377.1"
                     /transl_table=11
                     /translation="MPNTRRSGPDAGTVAAARAGDRQALEHLVAHSLPLVYNIVGRALN
                     GHADTDDVVQETLLRMVRGLSELRDPAAFRSWLVAIAVRQVRNRQQDRAAALDRSAPIE
                     EAEAIPDPALDFAGLTVLRLGLTEQRREIAEATRWLDPDDRELLALWWLKETGELEQAD
                     LVAALGLSSGHAAVRTGRMKKQLDLSRLLVRALAADPRCPGLAATTTGWDGTPGPLWRK
                     RLARHVRDCARCTGERNGLLPAERLLYGLPLLAVPPSLDPARILAALTPGGPGGHSGSG
                     EPGGSHSDGPGGHSGSSGGAPGRGSGHRRPRPVRTAKPLLAKPVLGGAALVLVAAAVLV
                     GAELVPGQDTVPAAAPGPSGAVAPPTAAEAAAPPEPDGASPSAPPTPSPSAPPASSPVP
                     SESVPRSATAAASAPVAQDAAVVASARKGVGVWAFDGASQALAASGAGWYYTWGTQHPG
                     ISTPASASFVPMIWGASSVTDAALAQARANGPYLLGFNEPDMAAQSNLTVDRALELWPQ
                     LMRAGQVLGSPAVAYGADTPGGWLDRFMAGADAKGYRVDFITLHWYGGDFRTPQAVQQL
                     TAYLEAVHRRYHKPIWLTEYALIDFSQGTRFPSADQQAAFVTASTEALDALPYLQRYAW
                     FGLGADPAKPSSGLFTDGTTATAAGRAYRAAR"
     gene            17767..19392
                     /locus_tag="OU787_RS02490"
                     /old_locus_tag="OU787_02490"
     CDS             17767..19392
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134230.1"
                     /locus_tag="OU787_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02490"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_268658378.1"
                     /transl_table=11
                     /translation="MSDVAVVCSHLSFSWPDDTPVFHDLSFSVPPGRTGLVAPNGSGKS
                     TLLRLIAGELRPAAGSLTISGTLGYLPQSLPLTAGLSVAQVLGVDGVIRALDAVESGDV
                     AEEHFAVIGDDWDIEERTRAQLDRLGLGALALDRDLGTLSGGQVVSLGLAAQLLRRPDV
                     LLLDEPTNNLDAAARHRLYDVLSEFNGSLLLVSHDRALLDRMDRIAELDGGELRLYGGD
                     FTAYQEAVRAEREVAERNVRNAEQQLKREKRELQQARERADRRASNAAKNLKNAGLPKI
                     FAGTMKRGAQESAGRSGQVHAARVDEARARLDEAGRAVREEQRLSLELPDTQVPAGRTL
                     FHGEGMRARLGGTEVFGPDGADLIVRGPERIALTGPNGAGKTTLMRLVSGDLAPEGGEL
                     RRGEGRIAYLSQRLDLLDKGLSVAENFARSAPERPEAERMNLLARFLFRGAGAHLPVRV
                     LSGGERLRATLACVLCAEPAPQLLLLDEPTNNLDLVGVGQLESALNAYRGAFVVVSHDE
                     RFLAEIGVGRRLRLADGRLTEVAA"
     gene            19389..21038
                     /locus_tag="OU787_RS02495"
                     /old_locus_tag="OU787_02495"
     CDS             19389..21038
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134231.1"
                     /locus_tag="OU787_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OU787_02495"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_268658379.1"
                     /transl_table=11
                     /translation="MTALIAHDLVRVLGGRRVLDGLSLTAAPGRRIGLIGENGCGKSTL
                     LRVLAGVDEPEAGSVVRPADLGFLHQELPFDPAADVASVLAEALREARADLAELERLGA
                     ELAALPEQHPSLPGLLAQYGHRLEQAEDRGSWDADRRAALALDGLGLSAVGPERTLGSL
                     SGGQRGRLALAALLVRRPSAVLLDEPTNHLDDAGSAFLEAQLRSLPGAVVVASHDRAFL
                     EAVCTDLVDLDPAADGPVRFGGGYLAYLAAKRAARGRWERRHAEERQEIAELEHTAGVT
                     AHRVAPDRGRTDNEKMGYGHRAGRVQQQVSRRVRDASRRLAELERTRVAEPPVPLRFTP
                     PAPEPSAPEPASPDPSAPLLSLHGVGVPGRLAPVSLQLGCTERLLVTGGNGTGKSTLLA
                     VLAGRLDPAVGEVRRRPGLTVGLLAQDTVFARPDRTARETYALALGPEPAERVPLSALG
                     LLAAADLDRPVGALSVGQRRRLALALLVARPPRLLLLDEPTNHLSPLLCDELEEAIGSG
                     GPGAVVLAGHDRWLRRRWRGRELTLPGGGPRE"
     misc_feature    21921..21936
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.28"
                     /tool="antismash"
ORIGIN
        1 cgtactcggc gagggagacc gagacgttga cgccggcggc gcggagggca ccggcgacgt
       61 cctggctgtc gcggccctcg acggtgaagg tgacgatggc gcaccggcgc gcgccccggt
      121 cgtgcacccg caccccgggg cgggcccgca ggcgctcgcg cagggctgcg cccaggcggg
      181 tggcgcgctc ggcgatcgcg tccgggccga gggcgagggc gtactcggcg gcgacgccga
      241 ggccgatccg ggcggcgtgg ttggcctccc agctctcgaa ccggcgggcg tcggcgcgga
      301 cccggtagct gtccgccgag gtccaggtcg ccgcgtgcag gtcgaggaac gggggttcca
      361 gccgggcgcg gatccgcggc gagcagtaca ggaagccggt gccgcgcggg ccgcgcagga
      421 acttgcggcc gggcgcggtg agcaggtcgc agccgatctc gccgacgtcc aggggcagtt
      481 ggccgacgga ctggcaggcg tccagcaggt agacggcgcc ggcctcgcgg gccgccttcc
      541 cgatctcggc ggccgggttg accaggccgc cctgggtggg cacgtgggtg accgcgatca
      601 gtttcacccg ttcgtcgacc atcgcgcgca gcgcgtcgac gtcgagctgc ccgtcggcgt
      661 cgtcggggac ggtctccacg ctcaccccgt ggcggcgggc cgtctgcagg aaggcgatgg
      721 cgttgctcgc gtactcggcc cgggccgtca ggatccggtc gcccggcgcc cagggcagcg
      781 cgtagaacgc catgtcccag gccctggtgg cgttctccac cagggcgatg tcgtcccgtc
      841 cggcgccgat cagcccggcc agcgcgtcgt acgtccgctc gatccgcccg gcctgccgcc
      901 gcgccgcctc gtaccccccg acctcctcct ccagccgcag gtgctccacc accgcgtcca
      961 ccaccggccg gggctgcagc gccgcccccg cgttgtcgag gtgcaccacc cgcccgaccc
     1021 cggccgtctc ccgccgcacc cgcccgacgt cgatccccgc caccagcgcc cacccctccc
     1081 gcgaccacgg ccgtccggtt ccccggtgtc cagggtgaac ggcccggcgg cggggccggg
     1141 ttcccgccgt ccgccgggac tcaccgggtg gtggggaggg cgggcaggac ggtggtgcgc
     1201 aggaggtcga ggaagaggtc ggggcggcgg tagacggcga agtggccggc ttcctcgatc
     1261 agggtgaagg acttggcggg ggcctggacc cggtcgtaga aggcgcgggc gcgggcgggg
     1321 gtgttgacca ggtcgcgggc gccctggacg aggaagaagg ggacgtcgaa gcgggtgccg
     1381 tcggcgtggt cgtcgagggc ggcggtgccg gggaggacgg cggcggagac caggaagctc
     1441 ctgaagaagg tgccgagttc gggcagggag tgcagcgggg agtaccagag cgacttcgtc
     1501 accacggact tcatcgcggc gaaggtgtac gggtcggtgg cggcggcgaa gcggttgaag
     1561 tgggcgaact gctcggcgct ccaggcccgt tggtcggggc ccgccgcccg gacggcggcg
     1621 gcctccttct tcttgccggc ccggtcgagg cgctccagcg cgtcgtggta gtcggtggtg
     1681 tcgcggccgc cgtcgaagat cttctggtcg gtgccgacgt aggcggagac caggtcgggg
     1741 cggctgcggg cgatccgcag gccgagggcg ctgccgaagg agcagcccag caggacgacc
     1801 cgggtgacgc cgaggcgggc gcggacgtgc tcgatcacct cgacggcgtc ccgcagcagc
     1861 cggtcgaagg tgagttcgcc ctggccgtcg gcgccggagc ggcgcagggt cttgccggtg
     1921 ccgcgcatgt cccagcggac cagggtgacg tggcgctccc agtcgcggga gaggtgggcg
     1981 aggacggcgt tggaggagcc ggggccgccg tgcagttcca gcacgacggg gttggcgcgg
     2041 tcctggccgc gtaccgagat ccactggtcg aggccgccga tcggggcgaa gtggctctcg
     2101 tcgacgcccc gtccggtgtc gatgcgcagg tcgcgggcgc ggccggcccg gacggcggcg
     2161 cggtgggcga ggagtccggc gacgggggtc gcggcggcgg cggcggtgag ggcggcggcg
     2221 atgagcacgc gggtctccag ggatgcaggt ccgttaactg tgtatgtcat acacagctga
     2281 ttactgtgta agttatacgc agttgttggg cggttggcaa caccgcggtc ggacggccgt
     2341 cggcacccgg ccgaccgccc gcggcccgga cggagaggag gccggtcgcg tgccggcgaa
     2401 caaggagagc cagcgggacc cgaacgtcag cctggcgctg ctgtggggcg aggccgagga
     2461 gcgcccccgg cgcgggccca ggccgaagtt cacgcccgcc gaggtggccc ggcacggcgt
     2521 cgcggtcgcc gacgccgagg ggctggaggc gctctcgatg cagcgggtcg ccgaggcgct
     2581 cggggtcacc acgatggcgc tctaccgcta cgtccccggc aagcccgacc tcgtcgacct
     2641 gatggtcgac accgtgctcg gcgacccgcc cgccctcgac gcggtgccgg gcggctggcg
     2701 gccccgcctg gaggtctggg cccgcgcctg ctgggacgtc taccgcgccc acccctggat
     2761 cctgaccgcg accggcctgc gccggcacgc catgggcccg cgccaagtgg cctggctgga
     2821 cggcgcgctg gccgccctcg aacccaccgg actcgacgcc cggcagcggc acgacgccgc
     2881 gatcctggtg ctcagcctgg tgcgcagcct cacccaggag tccctggacc gcaccgagga
     2941 gggcgaccgg gagtgggacc ggctcaccgc cgaccagctg gcccggcacg ccgaccgctt
     3001 ccccgcgctc acccgcgccg ccgcggccgg ggccttcgcc cccgcccccg ctccggcgga
     3061 cccgctcgcc ttcgggctgg cctgcgtgct ggacggcctc cagggcctgg tcgagcgcac
     3121 cgccgggccc gacgggggct gagcccgggc ccggcggggg ctgagcccgg gcacggcggg
     3181 ggctgagccc gggccgggcg ggggccgggc gggggccggg cgggggccgg gcgggaccga
     3241 gcagcggccg agccgggccg agcagcggct gagctgggcg gtgcggggtg gtccagggtg
     3301 gtgcggggtg gtgcagggtt caccatgaag tcgggtgcgg gcttcatggt gtgctcccgc
     3361 ggcggtgacc taccgtcgag ctgtgatgat tcgacccggg ctgaggcgcc cggcactcct
     3421 ggcccggcgg gcgcggcgtg acgccggctt cctggccacc ggcgtcctgc cgcacctggc
     3481 cctggtcccg gtgtgggcct gggccgcgac gttcatggcc cggacggggc actggaaacc
     3541 ggccctggag gtggcggtcc tcctgatcgt gctcggcacc ccgctggtga cggccgtcca
     3601 gcgggtccgc caccgcatcc tcctcggggt ggacgtggtg cccccggcgc ccgctcccga
     3661 gccgtggtcg tgggcggtgg cggcccggca ggcgctcagc tggctgacct cggcgcagac
     3721 ctggcgccag gtcggctacc acctgctgct cggcccgctg ctggccgccg cggagctgct
     3781 ggtgctggcc gccgccgtcg cgggcctggc cggcgccacc gcctacggct gggcctggtc
     3841 ggtgcccgcg cgggagcgcg ggggctggct cgagtacgcg acgcaactgc cgtggtacac
     3901 gctgggcggg ctgctcctgc tgggcgccct gccctgggtg gcgggcgcgg ccgcccgggg
     3961 cgagtcccgc gcggccgcgg ccctgctcgg ccccagccgg tcccaacggc tccagcagcg
     4021 ggtcgagcac ctggcggaga gccgtaccgg cctgatcgag gcggtcgacg ccgagcgccg
     4081 ccgaatagaa cgggacctgc acgacggcac ccagcaacgg ctggtctcgc tcgccgtcaa
     4141 cctcggcctg gtcctggcca ccacccccga cctgcccgac ggggcccgcg cggcggtcgc
     4201 cgaagcccac ctggaggcca agcacgcgat cgccgaactc aacgacctgg tacgggggct
     4261 gcaccccgcc gtgctggagg accgcgggct ggacgcggcc ctgtccggcc tggccgcccg
     4321 actccccctg ccggtgcgcc tgcgggtcga cctcgacgaa cgggtgccgc ccggcgtgga
     4381 gtcggtggcc tacttcgtga tctccgaggc cctggccaac gtgatcaagc acgccggggc
     4441 gacccgcacc gaggtgacgg tcagacaggt cggttcggtg ctgcgggtga acgtcacgga
     4501 cgacgggctc ggcggcgccg acccctccgc cgggacgggg ctgggcgggc tggccaaacg
     4561 ggtcgacgcg atcgacggct ccttccacgt gagcagcccc gtgggcggcc ccaccaccgt
     4621 gaccgcggag ctgccgtgcg cgcggtgatc gccgaggact cggtgctgct ccgggtcggc
     4681 ctggtcaagg tcctggagat gggcggcttc caggtcgtcg ccgaagtcga cgacgcgccg
     4741 tccctgttgg cggcggtcga gcagcaccgg cccgaactcg ccctggtcga cgtccggatg
     4801 ccgccctcct tcaccgacga gggggtgcgc gccgccctgg agatccgccg caggcggccg
     4861 gggacggcgg tggtgctgct ctcccagtac gtcgaggagc gctacgcggc cgacctgctg
     4921 tccgccgaca ccagcggcgt cggctacctg ctcaagcagc gcgtggccga cgtcacggag
     4981 ttcgtggaga cggtccgccg ggtcgccggg ggcggcaccg cactggaccc gcaggtcgtc
     5041 gcccaactgc tgctgcgccg cagcaacgac ccgctggaac ggctgacccc gcgcgaacgg
     5101 gacgtcctgg ccctgatggc ggaggggcac tccaacgtcg gcatcgcgga gaccctgacg
     5161 atcagtgaga gcgcggtcgc caagcacatc aacaacatct tcgccaagct cgacctcccg
     5221 gtcgccgaca gcggccaccg ccgcgtcctg gccgtgctgc gcttcctcgg cacgtcccgg
     5281 tcctgaacgg ccccggccgg ccctgaacgg ccgccccggc ccgaacggac cctcctcccc
     5341 gcgcccggcg ggtggtgcta gcctcggtgc accgcccgcc gccgcgccgc gcccgtccgt
     5401 ccgcgcgtgc ccggccggcc ggccgttccc cgctgccgtt tcccgctgcc gttccctgct
     5461 gccgacgccc cggtccgctg tcctgccgac cgccgggccg gtatcgcacc gcagcgcact
     5521 gcacaccgca gcgcaccaca ccgcaccaca ccggccgacg ccctcccgcg cggccgaacg
     5581 cccctgcccc gcccggaggt cggccccgcc atgcgtccca ccctgttcac gatcgaccgc
     5641 tccggccccg gccggatcag caccatggcc cggccgcgcg gcggcgactg gctcgcggag
     5701 gagctggccg cgctggccgc cctcggggtg agcgagctgg tcagcgcgct caccccggcc
     5761 gagtgcgccg agctcggact ggacgcggaa ccgtccctcg cccgcgccgc cgggctgcgc
     5821 ttcaccgccg tcccgatccc ggaccgcacc gtccccgccc cgtccgaagt cctgccggtg
     5881 ctggacgggt tggcccggcg gctggccgcg ggcggccacc tggtggtgca ctgccgggcc
     5941 gggatcggcc gctcctcgct gctggcggcc gccgtcctgg tccgctccgg cgcggacccg
     6001 gacgacacct gggcccggat cgcccgggcc cgcggcctga ccgtgccgga cacccccgag
     6061 cagcgggcct ggaccgcccg gatcaccccg ccgcaccggc cgtgaggctg tgcggccgca
     6121 cggtcgcggc gggtcagtgg tggaacagcc gcaggccggt gcgcaccagc gtgatgccgt
     6181 gctcggcgca ggccgtctcg acctcggcgg agcgcaggga gccgccgggt tcggcgatcg
     6241 cggtgacgcc gtggcggcgg gcgtggtcga cgttgtcgcg gaacggcagg cagccgtcgg
     6301 agacgaaggc gacgccgtcc aactcggccg cccagcgggc gcgttcgtcc gggccgagct
     6361 cgtcggggac gtcgccgtcg cgcagggcgg cggcgaagcg ggcgcgctcg tcgggcgtca
     6421 agtcgccctt caggtagcgg atctgccagt tgatccggtc ctgccggcgg acctcggggc
     6481 ggaagtcgag ggcccggacg gccgggtggc ggcgcagcca ccaggtgtcg gtcttggcgc
     6541 cggccagccg ggtgcagtcg acccgggact gctggccggc gccgatgccc agggccgcgc
     6601 cgccgcgcag gtagcagacc gagttggact gggtgcggcg cagcacggcc aggccgagca
     6661 gcaggtcgtc ggcggcggcc ggggtgagcg cgccgacccg gacgtcggcg agcagggcgg
     6721 cggtgagcgg ggtggtgtcg gtgtcctgga ccaggcgcac gccgtgcacc tcgcgggtct
     6781 cgacggcggg cggggtgcaa ccggggcggg cctccaggac gaggtagcgg ccgttcttct
     6841 tccgggccag cacgtcgagc acgccgggcg cgtagccggg ggcgacgatg ccgtcggaga
     6901 ccacccgggc gagcaggtcg gcgagttcga ggtcgacctc gtgcgagacc gcgacgaggt
     6961 cgccgtagga ggacttcggg tcggcgtcgc gggcccgcag gtaggcggag gtgagcgggc
     7021 cgacggtggc cgggtcgagg ccgtacggtt cggcggcggc ccggtcgacc ggtccggcga
     7081 gggcggcgcc ggccggggag acgtgcttga aggaggcggc agcggggcgg ccgaacaggg
     7141 ccgcggcctc gctgacgagc tgccaggcgt tcagcgcgtc cagcaggttg acgtacgagg
     7201 gctgtccgtt gagcaggcgc agcggcaggt cggtgccggg cagcggctcg atccgggcgc
     7261 gggtgttctg cgggttgatt ccgtaccgaa ggtccatggt ggtggccccc tccgtgaagt
     7321 cgcgtgtcgg cttcggagga cacccaggcg gacggtgccg gtcccgtgct gtgcggcgcc
     7381 gctccccggt ggtgctccac ctctcgccag tcgcgacggc gccgatgcta gcagcctccg
     7441 gcgggagcgg agttggggac ggcggcgggg ctgggggctg ggggtggtgg tggggccggg
     7501 ggcggtggcg cccgtgttcg gccgggcgtc agcggcgctc cgccccgatc ccgcggtccg
     7561 ttcctccggc caggaccgcg tccgcgacca cggtgaagag gtggtcggcg cgcggtgcga
     7621 acgagccctg gtcgccgagc cacgcgaggg ctgcgacgag ggcgaacagt tccgtgccgt
     7681 cgaggtcggc ccgtgcggcg cccgcggcct gggcccgggc gaggagccgg gtgcccgccg
     7741 cgcgcatggt gacgcacgag gcgtggagcg cggaaccggt gtcctcgatg gcggccgcca
     7801 tcagctcggt gacgccccgg tactcgcgtg cgaccgcgac gcagtcgcgc agccaggtga
     7861 cgagagcgtc ctcgggcggg tccgaggctt cgagtgcggc cgcccgttcc gccagcccgt
     7921 cgaagctctc ccggagcagg gcgtcgagca acgcctcccg ggtcgggaag tggcggtaga
     7981 gcgtggggag ggcgacgtcg gccctccggg cgatgtcgcg cagggacgcg tcggcgccct
     8041 gctcggcgac gacgacgccc gcgacggcga gcagctggtc gcggttcttc ctggcatcgg
     8101 cccgcaaggg tcctcctttg acagccgtag cactgctaca tatattcgta ccactgctac
     8161 ggaaacacgt agcagtgcta cgcctagcct agcccgcctg cgggaaagag ggagaatctc
     8221 catgtcggcg aagacgatga gggcgatccg actgcacgag ttcggcggcc ccgaggtact
     8281 gcgccacgac gaagtgccga tcccccggcc gcagccgggc gaggtgctcg tgcgcgtcca
     8341 cgccgtcggc ctcaaccccc cggactggta cctgcgcgac gggatgcccg gcattccccc
     8401 cgaactgagg ccgcccgtga gcctccccgc cgttccgggg tcggacgtgt cgggcgtcgt
     8461 cgcggcggtc gccgaggacg tgacggactt ctccgtcggc gacgaggtct tcggcatgct
     8521 ccgcttcccg agcttcgacg gccgcgcgta cgccgagtac gtggcggcgc ccgccgccga
     8581 cctggcccgc aagccggccg gcgtcgatca cgtgcacgcc gcgggggcgg ccatgtcggg
     8641 gctcaccgcg tggcagtacc tggtggaact cgggcacgac caccccaacc ccctccagcc
     8701 ggcgcagcac cgccccgtac cgttggaggc cgggatgacg gtgctggtca acggcgcagc
     8761 cggcggcgtg gggcacctgg gcctgcaact cgccaagtgg aagggcgcgc gcgtcatcgc
     8821 ggtcgcctcg ggcgcgcacg agcagttcct gcgcgagctc ggcgccgacg agttcgtcga
     8881 ctacaccaag acccgccccg aggaggccgt ccgggacgtc gacctggtgc tcgacaccgt
     8941 cggcggcccc ggcagcggcc gcttcctgcg gacgctcagg cgcggcggcg cgctgcactt
     9001 cgtcttcatc gccacgtacg acccggcgga ggtcacgagg ctgggcgtca cgacctcgat
     9061 cacccaggtg cgctcgaacg gccggcagct cggagaactc ggccgcctgc tcgacacggg
     9121 cacgctccgc gtcgccatcg acagcacctt cccgctcgcg gacgcccgga aggcacacga
     9181 acgagccgcg cgcggacacc tccggggcaa gatcgtgctc accgccgtgt gaggaccccg
     9241 ttcgtgaacg ccgccacggg aagcgagtcc cccgcgacgg caggaggacc gcgatggcga
     9301 cgcccgagga cgacgaccga ggacgccgtc gacgacatgt tcggcgggcg gggaggcggc
     9361 cgggcaggtg caccggggtg gggccggaca gtggcgtccg ggtgggttcg gccatgtcac
     9421 agggaggggc gatgtcctcg tccgacaccg tgtcagggtc cgttccggag aagggccggg
     9481 gccggttgcg gcggttgggc gagtggtgcg cgcggcggcg cctggtggac cccgcgccgg
     9541 ctggaccgga tcctcccgga catcgacgcc gagggcacca acatctcggc caacgaggcg
     9601 aattgacggg aggtcaggaa tcttccggac gccactcccg tcccggtggc accaccgctc
     9661 acaccgtccg gccgccggtg tggaagcgga gcatccgccc ccttgtcagg tgcaccgttc
     9721 ctgcctacct tcgtgctcca ggaccccggc ccgatcgggc cggacggtcc gcggcgccgg
     9781 acgcaaaccc gcggccgcgc cggacgcgcg acaagacctg gaggcgtcac atgcccgttg
     9841 ccacccccac cgcgatccgc gacgccggcc cactggccgt ggacgacgag accctggtgt
     9901 tcgaggacga cgaccgcacc gaccacgacc ccaccgcctg tctgtccgac ccgtgggtga
     9961 ccgcgaccac ccgggtcgcc tgcgacttca actcctgacg gtggccggct ccgtcgccgt
    10021 ccgccgcccc tggtccgacg acacctggtc gtacctgaac gatccgcgga tgccggcgat
    10081 ggagcacggt tggaagctcc acgtctccgc ccgcccgggc accctggccg ccgtcctcgc
    10141 gctcgtcctg ccggtgctgg agcggcacgt ctgccacgcc aagtgggccc gcgaccccga
    10201 ggtgctgcgc actctcaact ccggtacccg gaacgccgct tcggtcggca aggcggtcac
    10261 cgtctaccca gtcccgggcg aactcctgcc gctggccgcc gagttggccg acgtcctgcg
    10321 cggccgggag gggccgccga tcaccggcga ccgccgcctc gcccccgacg cgcccgtcta
    10381 ctaccggtac gggccgttca ccggtgacta ccggaccggg cgcagcgggc gcctggaatc
    10441 cgtgatgacc ggccccgacg gacagctctt cgacggcctg gcgggcaccg cgtaccgctg
    10501 cccgccgtgg gccgcggacc cgttcacccg ccccgcggcc gccccgcccg cgtcgcccgc
    10561 gccgggcgcg ccagccaccc cgtccgcggc ggacaccccg accgcggcgg ccggtttcgg
    10621 cggcgggcgc taccgggtga ccggcgggat cgcccgcaag gcccagggca acgtctaccg
    10681 cgccctggac ctggtcaccg ggctggccgt ggtggtcaag caggcccgcg cctacgtcgc
    10741 cgaggacgcg gacggcgccg acgcccgcga ccgcctgcgc aacgagcacg ccgtcctcac
    10801 cgcgctcgac ggcctccccg gcgtcccgcg cgccctcgac tacttccgcc accgcgccga
    10861 cgagtacctg gtcacgaccg actgcggcag ccgcgacctg cgccgcgagg tgcacgacca
    10921 cgggccgttc gccgcgatgg gaacggaccg cccgcacccg tccggcccgc tcgccgcccg
    10981 gctgctgcgc gtcctggacg gcgcccaccg gcggggcgtg gtggtgcgcg acctcaagcc
    11041 cgacaacgtc gtgctggacg ccgaagggca ctgccacgtc gtcgacttcg gcatcagcgc
    11101 ccggcacggc accggcccgg acggctccac ccccggctac agcggccccg tacaccggcc
    11161 cggcgccccg gcactgcccg ccgacgacta ccacgccctg ggcatgaccc tgcacttcgc
    11221 cgccaccggc ctggacccgg tcgtgctcga ccccgacccg gccgtcaacc gcgaacgcac
    11281 cctggcctgc ctggagttcg ccatccccgg ccccgcccac cagcaattcc gcgccctgat
    11341 cggcgatttg accagccccg accccgccac ccggaccgcc ggagcggacc gcctgcgccg
    11401 ggaagccggg caggcggccc tccaacagac ttcgaataaa gccaagttga ccagaacggg
    11461 cctcccgcgc cgggaagccg agcggccgag ccgccgacgg ccgcccgccg caccgcagat
    11521 accggccgac ctgctggcgg aggtcgtcga gcacaccgtc gcggtctgcg tcgccgaggc
    11581 ccaccggatc gccgacccgg cgcgtgccga ccggtccgcc gtccccgccc cggtcgacgt
    11641 ctacggcggg agttccgggc tcgggctgga actgctccag cacctgcacc gccccggcgt
    11701 cccggccgcc gtcgccgcgc tcgccgactg gacggcccgc caacaccgca cgctcccggc
    11761 cgggttgtac tgcggccgga ccggcgtcga cctgttcctg accgccgccg gcgcaccgcc
    11821 tccgcacacc gccaccgacc tgccggacca gcgcccgggc ggcggaccgc cggaagccga
    11881 cctgatcgac ggcgccgccg ggaccggcct cggccacctg ctcctcgccc gcgcccaccc
    11941 ggccccggcc cccgccgtcg ccgccgccgt caccgacgcc cccgccgatc ggcacctcgc
    12001 cgccgccacg gcctgccgcg accagctcac caccgggcac gcccgcctca cccctgccgc
    12061 cgcgccccgt cccggcgacg ccgccctcac ccgggggatc gcccacggcg acgcgggggt
    12121 cgcccacttc cttctcgcgc acgcccgcgc caccggcgac ccggtctccc ggcaccacgc
    12181 cgccctggcc tgcgcgcgcc tcgccgacgc caccccggca ctgctcgccg ccgccacccg
    12241 gcccggcgcc agccgccgct acggctcctg gtgccgcggg ctggccggga tcggcgccgt
    12301 cctggcccgc gccgccgagc agctcagcga acccgcccac cgcgcgctcg ccgaacggtg
    12361 cgccctcgcc tgcctggacc tggccccgcg gatgccgctg gtcacccagt gctgcggcct
    12421 ggccggcgtc ggcgacctga tgctcgaact cgcccccgcc gcaccggagt tccacgaggc
    12481 cgcgggcacc gtcgccgccc tcgtgctggc ccgctcggcc ggccccgccg cccggccggt
    12541 cttccccgac gccggcctgg tccgccagtc cttcggccac gccaccggca cccccggcgt
    12601 cctcgccttc ctccgccgcc tgcactcccc cggcagtccc ccgctcggca ccctcccctg
    12661 accgcccgac gacccgaact cccgcctccg ggacggacgt tcaccgcccg gctgcgccgg
    12721 caggacgaca acggcccgca ggagcgcctg ctgccgccgc gcaagagccg gaccaaccgc
    12781 cggcctcacc cctcgacggc agcacccccg gccccggccc cagcaccgct cccgaccccg
    12841 gccccagcac cggccccggc cccgttcccg cccgccgcca ctgccgcgag cagggccagc
    12901 agcggtgaga cgtcccgctc gaaggtgaac tcccgcagca gggtggtcca ccggccgtcc
    12961 tcccagcgcc atacgaagac gtagcgggcc gggaggccgt cctcgcagcg gtacatgacg
    13021 accgtgccct ggtcgccgcg ccgccccgcg gacaggaagc ggacgtcgtc cgtgccgccg
    13081 tccgcgacgc cctcgccgcg cgcggccagc gcccggaacc gcgccatgaa gtgcgccttc
    13141 gtcagcaccg cgacccggcc cgcctcgtcg gtccggacgt tctcgaactc ctcgtcgtag
    13201 agcgcctcca gcgccgccag gtccatcgcc gtgcccgccg ccaggtactc ccgcatccgc
    13261 gcgaccagcg tcccgtccag gtgtccgtcc atcgttgcgc cccctcgtcg ttcgtccttc
    13321 gttccggtgc gcccatcgtc gcggcggccg ctgtcggatc acccgcagcc cgctgtcggc
    13381 gcactgtcgg cgcgctctcg gccccctctc ggaacgccct cgaacgacgc ccttccccct
    13441 tgccgcacaa agtatttcgt gcccggagcg ggaggcacgt agcgtcccgt gccatgaccg
    13501 atgagacgtg gacgtacgcg acggcggggg aactgacggc ggccctgcgg gccgggaagg
    13561 tcagttcggt ggagctgacc gaggaggcga tcgggcggat cgagcgggag gacggggcgc
    13621 tgaacgcgat ctgcgcgccg gacttcgagc gggcccggga cgccgcccgg gcggccgacc
    13681 gagcgcgggc gcggggggag gaacggccgc tgctgggtgt gccggtgacg gtcaaggagt
    13741 cgtacaacgt ggccgggctg cccaccactt ggggcatgcc gcagttccgg gaccacgtcc
    13801 cggccgagga cgccctgcag gtggcccggg tcaaggcggc gggcgcggtg gtgctcggca
    13861 agaccaacgt gccgctcggg ctccaggaca tccagaccta caacgagatc cacggcacca
    13921 ccgtcaaccc gtgggaccgc acccgcacct gcggcggctc ctccggcggc tcggccgccg
    13981 ccctggccgc cgggttcggc gcgctgtcgc tgggcaccga catcgccggt tcgctgcgca
    14041 cccccgccca cttctgcggc gtctacgcgc acaagccgac cctgcacctg ctgcccactc
    14101 gcggcatggt cccgccgcac gccccggcgc tgcccgccga catcgacctg gccgtcgccg
    14161 ggccgatggc ccgctcggcc cgcgacctca ccctgctgct cgacgtgatg gccggccccg
    14221 acccgctgac ctccggcctg gcccacaccc tggacctgcc gcccgcccgc cacgaccggc
    14281 tctccgactt ccgggtgctg gtcctggacg agcacccgct catcccgacc ggcgccgacg
    14341 tccgcgcggg cctggcccgg gtcgtcgacg cgctcgccga gggcggcgcc cggatcgaac
    14401 ggcacagccc gctgctgccc gacctcgccg acgccgccga gctctacacc ctgctgctgt
    14461 cctccgccgt cgccgtccag ttcccggtcg gcagccagca gcaactcgcc gcccaggtcg
    14521 ccgggttgag cgaggacgac cacagcctgg tcgccgcccg gctgcgcggc ctgctgctct
    14581 cccaccgcga ctggctgggc gccgaccgcc gccgcgaact gcaccgccac gcctggcggc
    14641 agctcttcgc cgagttcgac gccgtcgtcg ccccgatcac ccccaccgcg gccttcccgc
    14701 acgaccagga ccccgacctg atgaaccgcc ggatcaccgt cgacggcacc gcccacacct
    14761 acttcgacca gctggtctgg gccggtctcg ccaccatgcc cggcctgccc gccaccgccg
    14821 tccccaccgg cccgtccgcc gcgggcctcc cggtcggcgt ccagctgatc ggcccgatgt
    14881 acgaggaccg caccccgctg cgcctggccg aactcctgga ggagcggctc ggcggcttcc
    14941 gcccgccccg cgcactccac tgaccgggcc cggccccgtc aggtgccccg gcccggaccc
    15001 gggcacctga cgggggctca gcgggcggcc cggtaggccc ggccggcggc ggtggcggtc
    15061 gtcccgtcgg tgaacaggcc gctgctgggc ttcgccgggt ccgcgccgag gccgaaccag
    15121 gcgtagcgct ggaggtaggg cagcgcgtcc agggcctcgg tggaggcggt gacgaaggcg
    15181 gcctgctggt cggcgctcgg aaagcgggtg ccctgggaga agtcgatcag ggcgtactcg
    15241 gtgagccaga tcggcttgtg gtagcgccgg tggacggcct ccaggtaggc ggtcagctgc
    15301 tggacggcct gcggggtgcg gaagtccccg ccgtaccagt gcagcgtgat gaagtcgacc
    15361 cggtagccct tggcgtcggc gccggccatg aagcggtcca gccagccgcc gggcgtgtcg
    15421 gccccgtacg cgaccgccgg gctgccgagg acctgcccgg cccgcatcag ctgcggccac
    15481 agttcgagcg cccggtcgac cgtcaggttc gactgggcgg ccatgtcggg ctcgttgaac
    15541 cccagcaggt aggggccgtt ggcgcgggcc tgggcgaggg cggcgtcggt gaccgaggac
    15601 gcgccccaga tcatcgggac gaaggacgcc gacgcgggcg tgctgatgcc cgggtgctgg
    15661 gtgccccagg tgtagtacca gcccgccccg gacgcggcga gcgcctggct cgccccgtcg
    15721 aaggcccaca cgccgacgcc cttgcgcgcg gacgcgacga cggcggcgtc ctgcgccacc
    15781 ggggcggacg cggcggctgt ggcggaccgc gggacggact ccgacggcac gggcgaggac
    15841 gcgggcgggg cggacggcga aggcgtgggc ggagccgagg gtgacgcacc gtcaggttct
    15901 ggcggggccg ccgcctcggc ggccgtgggc ggcgcgacgg ccccggacgg cccgggcgcc
    15961 gccgccggga cggtgtcctg ccccggcacc agctcggccc cgaccaggac ggccgccgcc
    16021 accagcacca gcgccgcccc gcccagcacc ggcttggcca gcagcggctt cgccgtccgg
    16081 acggggcgcg gccgccggtg gccggaaccc cgacccgggg cgcccccgga ggaaccggaa
    16141 tggccgccgg ggccatcgga gtgcgacccg ccgggctcgc cggagccgga atggccgccg
    16201 ggcccgcccg gggtgagcgc ggcgaggatc cgggccgggt cgaggctggg cgggacggcc
    16261 agcaacggca ggccgtacag cagccgttcg gcggggagca gcccgttgcg ttcgccggtg
    16321 cagcgggcgc agtcgcgcac gtgccgggcc aggcgcttgc gccacagcgg gccgggggtg
    16381 ccgtcccagc cggtcgtggt ggcggccagg ccggggcagc gcgggtcggc ggccagggcg
    16441 cgcaccagca ggcgggagag gtcgagttgc ttcttcatcc ggccggtgcg gacggcggcg
    16501 tggccggagc tgaggccgag tgcggcgacc aggtcggcct gttcgagttc gccggtctcc
    16561 ttgagccacc acagggcgag cagttcgcgg tcgtcggggt cgagccagcg ggtggcctcg
    16621 gcgatctcgc ggcgctgttc ggtgaggccg aggcgcagga cggtcaggcc cgcgaagtcg
    16681 agcgcggggt ccggtatcgc ctcggcctcc tcgatcgggg cggaccggtc gagggcggcg
    16741 gcccggtcct gctgccggtt gcggacctgc cggacggcga tggccaccag ccaggaccgg
    16801 aaggcggccg ggtcccgcag ttcggacagt ccgcggacca tgcgcaacag ggtctcctgt
    16861 acgacgtcgt cggtgtcggc gtggccgttc agcgcccggc cgacgatgtt gtagaccagc
    16921 ggcaggctgt gggccaccag gtgttccagc gcctgccggt cgccggcgcg ggccgccgcc
    16981 accgtcccgg cgtcgggtcc gctgcgtctg gtgttcggca tgggtccgtt cctctacgtc
    17041 ggggtggcgg gtgcgccggg tgtacggatc ggagaccggc cgcgggggcg cccgccaaca
    17101 gaaattcttc cccggaccgg aatttgtgtt ggcggggacc cccggccggg gtctccgatg
    17161 cgtacacccg gtgcatccgc accccgaggg gcaggaggac ggcccgcgat ggcacgagga
    17221 caccgccgcc gcgccgtctc cggccccgcc tgagccaggc ggccgggcgg cccccaccgc
    17281 cccggccgcc gtccggccct gccgggtgcc gggcccccac cccggcccac ccggcccggc
    17341 agggtccgcc gggcaccgcg cccttcccct gcacggggcg cggtgcccgg ccttccccga
    17401 ccgaagacca tcggccgaag gccatcgacc ggccgccggc ccgtgcggcg gcaactcccc
    17461 ggtggggcga gctgttacag tcgggagtgg cgcagtggtt gcgcacgtgg cacatgcacg
    17521 gaagagggac agacgtggcg ggtgacgacg acatctccgg gtgagacccg gacctgacgg
    17581 ccaccgggcc ggtgcacgag gcgccgccgg agtggtccgt ttcgtcgttc ccttcttctc
    17641 cctcccaccc gtctctcggg cagtccgccg ttcccccggc tccgcggcac ccctccggta
    17701 cctcccgggg cccctccgga gcctgccggg ccgtgcgctg cccccggtgc cattcgaggt
    17761 cccaccgtgt ccgacgtcgc cgtcgtctgc tcccacctgt ccttctcctg gccggacgac
    17821 accccggtct tccacgacct gtcgttcagc gtgccgccgg gccgcaccgg cctggtcgcg
    17881 ccgaacggtt ccggcaagtc caccctgctg cggctgatcg cgggtgaact gcggcccgcc
    17941 gccgggtcgt tgacgatctc cgggacgctc gggtacctgc cgcagagcct gccgttgacg
    18001 gcggggctca gcgtcgcgca ggtgctgggc gtcgacgggg tgatccgggc gctggacgcc
    18061 gtcgagtcgg gcgacgtcgc cgaggagcac ttcgcggtga tcggcgacga ctgggacatc
    18121 gaggagcgca cccgcgccca gctggaccgc ctgggcctgg gcgccctcgc gctggaccgc
    18181 gacctgggca cgctcagcgg cggccaggtg gtctcgctcg gcctggcggc ccaactgctg
    18241 cgccgcccgg acgtgttgct gctggacgag ccgaccaaca acctggacgc ggcggcccgg
    18301 caccgcctgt acgacgtgct ctccgagttc aacggctcgc tgctgctggt cagccacgac
    18361 cgcgcgctgc tggaccggat ggaccggatc gccgagctgg acggcggtga actgcggctg
    18421 tacgggggcg acttcaccgc gtaccaggag gcggtgcggg cggagcggga ggtcgccgag
    18481 cgcaatgtcc gcaacgccga gcagcagttg aagcgggaga agcgcgaact gcagcaggcc
    18541 cgggagcggg ccgaccggcg ggcgagcaac gcggcgaaga acctgaagaa cgcgggcctg
    18601 ccgaagatct tcgcgggcac catgaagcgc ggcgcgcagg agtccgcggg ccgttcgggg
    18661 caggtgcacg cggcgcgggt ggacgaggcg cgggcccggc tggacgaggc cgggcgggcg
    18721 gtgcgcgagg agcagcggct gagcctggaa ctgccggaca cccaggtccc ggcggggcgg
    18781 acgctgttcc acggcgaggg gatgcgggcc cggctcgggg gcacggaggt gttcgggccg
    18841 gacggcgcgg acctgatcgt gcgggggccg gagcggatcg cgctgaccgg gccgaacggc
    18901 gccgggaaga ccacgctgat gcggctggtc agcggcgatc tggcgccgga gggcggggag
    18961 ttgcggcgcg gcgagggccg gatcgcgtac ctgtcgcagc gcctggacct gctggacaag
    19021 gggctgtcgg tggcggagaa cttcgcccgg tccgcgccgg agcggccgga ggcggagcgg
    19081 atgaacctgc tggcccggtt cctgttccgg ggcgcggggg cgcacctgcc ggtgcgggtg
    19141 ctgtcgggcg gcgagcggct gcgggcgacg ctggcgtgcg tgctgtgcgc ggagccggcg
    19201 ccgcagttgc tgctgctgga cgagccgacc aacaacctgg acctggtggg cgtgggccag
    19261 ttggagagcg cgctgaacgc gtaccggggg gcgttcgtgg tggtcagcca cgacgagcgg
    19321 ttcctggcgg agatcggggt ggggcgccgg ctgcggctgg cggacggccg gttgacggag
    19381 gtggcggcgt gacggcgctg atcgcccacg acctggtccg cgtcctgggc ggccgccggg
    19441 tgctcgacgg gctgtcgctg acggccgcgc cgggccgccg gatcgggctg atcggcgaga
    19501 acggctgcgg caagtcgacg ctgctgcggg tgctggccgg ggtcgacgag ccggaggccg
    19561 ggagcgtcgt ccggccggcc gatctcggct tcctgcacca ggagttgccg ttcgacccgg
    19621 ccgcggacgt cgcctcggtg ctggccgagg cgctgcgcga ggcccgtgcg gacctcgccg
    19681 aactggagcg gctgggcgcc gagttggccg ccctgcccga gcaacacccg tccctgcccg
    19741 gcctgttggc gcagtacggg caccggttgg agcaggccga ggaccgcggc tcctgggacg
    19801 ccgaccgccg ggcggcgctg gcgctggacg gcctggggct gtccgccgtc gggccggagc
    19861 gcacgctcgg ctcgctctcc ggcgggcagc gcggccggct ggcactggcg gcgctgctgg
    19921 tgcgccgccc ctcggcggtg ctgctggacg agccgaccaa ccacctggac gacgccgggt
    19981 ccgccttcct ggaggcccaa ctccgttcgc tgccgggcgc ggtggtggtg gccagccacg
    20041 accgggcgtt cctggaggcg gtctgcaccg acctggtcga cctggacccg gcggcggacg
    20101 ggccggtgcg cttcggcggc ggctacctcg cctacctggc ggcgaagcgg gccgcccgcg
    20161 gccgctggga gcgccggcac gccgaagagc ggcaggagat cgcggagttg gagcacacgg
    20221 cgggggtgac cgcacaccgg gtggcgccgg accgggggcg caccgacaac gagaagatgg
    20281 gctacgggca ccgggcgggc cgggtgcagc agcaggtctc ccgccgggtg cgcgacgcct
    20341 cccgccgact ggccgaactg gagcgcaccc gggtcgccga gccgcccgtc ccgctgcgct
    20401 tcaccccgcc cgccccggaa ccgtccgccc cggaacccgc ctccccggac ccgtccgccc
    20461 cgctgctctc cctgcacggg gtcggcgttc ccgggcggct ggccccggtc tcgctgcaac
    20521 tcggctgcac cgaacggctg ttggtgacgg gcgggaacgg gacgggcaag tcgacgctgc
    20581 tggcggtgct ggccgggcgg ctggacccgg cggtgggcga ggtgcggcgg cggccgggcc
    20641 tgacggtggg cctgctcgcc caggacaccg tgttcgcgcg tccggaccgc accgcccgcg
    20701 agacctacgc gctcgcgctg ggaccggagc cggcggagcg ggtgccgctg tcggcgctcg
    20761 gcctgctggc ggcggccgac ctggaccgcc cggtcggggc gctgtcggtg ggccagcgcc
    20821 gccggctcgc gctggccctg ctggtggccc gcccgccccg gctcctgctg ctggacgagc
    20881 cgaccaacca cctctcgccg ctgctgtgcg acgagttgga ggaggcgatc ggctccggcg
    20941 gcccgggcgc ggtggtgctg gcggggcacg accgctggct gcgccgccgt tggcgggggc
    21001 gggagttgac gctgcccggc ggcggccccc gggagtgagc ggtggcggcc ccgcacacgg
    21061 aggtggcggc caccgccccg ggcatggggg cggtggccgc cggtttcggc gctggtcgcg
    21121 ctaccggtgg ttacgggtag gagaccaggt tggaggggac ggtcccggtg ccggaggtcc
    21181 cggcgccggt gttgttgacc acgtgcagga actggccgtt gccgccgagc gagttgacca
    21241 ggacgtcgtg cagcttgacg ccgggcgcgt tcgggacctc gaagccgtgg tccatcacga
    21301 tggtcgggtc gacgttgaag tagcagtagc tgcccaggcc ccagccctcg tgggtggtga
    21361 cgttgtcctc gaccttgtag gcggcgtagc ccttcgtgct gccgttctgg atcgcggcct
    21421 ggttgggcgc gtcgtaggcg atctcgttct ggaagaagat cgtccggccg ccgttgccct
    21481 tccaccacac gtcgtacttg ttgaagtgct cgacgaacag gccggtggcg aggacgtcgt
    21541 tgccgccgac gacgaagccg tagtcggagc ggttggtctc ccagccgacg cccgcgccgt
    21601 ggtcggcgcg ccagatccag gtgtggtcga cgatcgtgtt gttgctgttg atcaccatgc
    21661 cgttggtggt cttgccggcg ccggcgccgc cgacccggac gaagacgtcc tggatgacga
    21721 tcgggtcggc cgcgtggttc gcgcccgggg tgtcgttgcc gacctggagc agggcctggg
    21781 agttgacggt gccggcgtcc agcagcaggc cggagacctt gacgccgtcg acgtcggcga
    21841 ccttgaccgc ggtcacgccg ttgtccggga cgacggtggc gaggccgagg ccgagcacca
    21901 cggtgtccgg gcgggtgatg ttgatggact ggtcgacgtg gtagacgccg ggggtgaaga
    21961 gcaggttgag gccctgggcg agagcctggt tgatgctcgc ggcggtcgcg ccgtccttca
    22021 ccacgtagaa ctggctgagc ggcagcgagg tgccctgcgg ggcgccgctg ccccaggagg
    22081 tgccgcgggc gttggtgcgc ttggcgggca cgaacacctt gtagtcgttg ccgtccaggt
    22141 acaggaacgg cttctcctgc gagacggggg tggtgtcgag cgtggtgtac ggcgggttcg
    22201 ggaagccctg ggcgggagcg ccctggacgc cggagaaggt ctggttccac acgccgttgg
    22261 agaagccgcc gatggagctg tcccgggtgt accactgctg ctgcgagtag ttgccgacct
    22321 ggccgtcgat cttcgagtcg gcgatgtagc cgccggaggc ccagccgtag ccgttcgggg
    22381 ccaggttgag gccgccctcg acgtgcatcc ggcggaacgg ggcggcctgc gagacggccc
    22441 agcggtcggt gccgctgacc ggcttgaggt gcaggttctc ggcggagcgc cagaagttct
    22501 gggtggcgtt gccgttgaac cagcccgcgt cgacggtgac gtcgccgttg aaggtggtgt
    22561 cgtccgggtt caggcccagg cccgcgatcg aggtgtagaa gccgatctgg gcgttgatgt
    22621 tgttgtacgt gcccggcttg aacagcagcg cgtagcggtc g
//
