LOCUS       NZ_JALAUV010000022      9458 bp    DNA     linear   CON 26-JAN-2024
DEFINITION  Bacillus inaquosorum strain EC49O2B-D16 contig_0000022, whole genome
            shotgun sequence.
ACCESSION   NZ_JALAUV010000022
VERSION     NZ_JALAUV010000022.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus inaquosorum
  ORGANISM  Bacillus inaquosorum
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 9458)
  AUTHORS   Dunlap,C.
  TITLE     Crop Bioprotection Bacillus Genome Sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9458)
  AUTHORS   Dunlap,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-FEB-2022) CBP, USDA-ARS-NCAUR, 1815 N. University St.,
            Peoria, IL 61604, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 21
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 346.2863018625785x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/24/2024 02:36:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,571
            CDSs (total)                      :: 4,491
            Genes (coding)                    :: 4,347
            CDSs (with protein)               :: 4,347
            Genes (RNA)                       :: 80
            rRNAs                             :: 4, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 1 (5S, 16S)
            tRNAs                             :: 68
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 86 of 144
            Pseudo Genes (incomplete)         :: 78 of 144
            Pseudo Genes (internal stop)      :: 27 of 144
            Pseudo Genes (multiple problems)  :: 40 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:50:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 9458
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALAUV010000022.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     protocluster    1..9458
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:>9458](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <1..>9458
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            <1..3555
                     /locus_tag="MOE71_RS22310"
                     /old_locus_tag="MOE71_22255"
     CDS             <1..3555
                     /NRPS_PKS="Domain: AMP-binding (139-532). E-value:
                     1.6e-115. Score: 377.9. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22310_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (637-705). E-value: 1e-24. Score:
                     78.5. Matches aSDomain: nrpspksdomains_MOE71_RS22310_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (715-1017). E-value:
                     2e-164. Score: 540.3. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22310_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1023-1177). E-value: 1e-52.
                     Score: 170.0. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22310_TIGR01720.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389714.1"
                     /locus_tag="MOE71_RS22310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MOE71_22255"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_268426376.1"
                     /sec_met_domain="AMP-binding (E-value: 9.7e-123, bitscore:
                     396.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-16, bitscore:
                     48.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 2.1e-78, bitscore:
                     250.5, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="EELVDKLKLTRDMSRNPLFDVMFVLQNMDQESIQLEELHLKPAAN
                     NGHQTSKFDLTLYAHEQPCGLLTFQMEFSTDLYKKKTIEKWLQYFINMLLSITQDNKAA
                     LGTINILNEDETHYLIHELNRTKIDYPRNETISRLFEMQAEQTPNAIAIVSDTQELTYA
                     ELNSRANQIASVLQRKGVGPDRVVALLTGRTPELIAGMLGILKAGGAYLPIASDLPVER
                     IAYMLSDSGAALLLQSEKTEKQLLDIACEQFIIEDIQKQGETKNFESSAGAHSLAYIIY
                     TSGSTGKPKGVMIEQRSVIRLVKNSNYITFTPADRLLMTSSIGFDVVTFEIFAPLLNGA
                     ALHLSDKQVFLDSYQLQRYIEHHGITTMWLTSSLFNHLTEQNETIFSQLNHLIIGGEAL
                     SASHVNRIRNVCPEVSIWNGYGPTENTTFSTCFHIQKTYELSIPIGRPVGNSTAYILDK
                     WGMLQPVGTVGELCVGGDGVARGYLGRPDLTKEKFVPNPFAPGDRLYRTGDLARWLPDG
                     TIEYVGRIDDQVKVRGYRVELGEIESALRQIDGVKEAAVLARTGQTGSKELFGYISVNA
                     GTNAEQVRSLLARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDFASKQMYVPPRD
                     DLEEQLALIWQEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRHGLSLQVSDLFRHPK
                     IKDLSPFIRKTERIIEQGPIQGDVPWTPVQQWFLSQDIEERHHFNQSVMLFHSDRLSEE
                     ALRAALKKLAEHHDALRMVYRNDDGRWIQINQGIQESQLYSLRISDLSQSESGWETQIK
                     QEVADLQQSINLQEGPLLHAAWFKTLTGDYLFLAIHHLVVDGVAWRILLEDLSAGYQQA
                     SSGQVIQLPPKTDSYQEYARRIQEYAQSSRLIREEVYWRSVEEQQAAELPYEMPLHEKT
                     DFSRRDSIRFSLSEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEG
                     HGREHILPELDISRTVGWFTSMYPALISFENHRDELGTAVKTVKDTLGRIPNKGVGYGM
                     LKYLTHPENKSITFSKTPDISFNYLGQFNDIERQDSFRPSSLGSGKDITHTWKREQIIE
                     MSAMAADKKLHFNLSYPPALFHRNTMEQLINRIEHFLRDIMKHCAGKQKAEKTLSDFSS
                     QSLTAEDLDSISSLVEEL"
     source          1..9458
                     /db_xref="taxon:483913"
                     /mol_type="genomic DNA"
                     /organism="Bacillus inaquosorum"
                     /strain="EC49O2B-D16"
                     /submitter_seqid="contig_0000022"
     region          1..9458
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..9458
                     /SMILES="NC([*])C(=O)N1C(CCC1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     CDS_motif       4..78
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0001"
                     /evalue="3.70E-10"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="25"
                     /protein_start="0"
                     /score="32.1"
                     /tool="antismash"
                     /translation="EELVDKLKLTRDMSRNPLFDVMFVL"
     aSDomain        421..1599
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22310_AMP-binding.1"
                     /evalue="1.60E-115"
                     /label="MOE71_RS22310_AMP-binding.1"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="532"
                     /protein_start="139"
                     /score="377.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEMQAEQTPNAIAIVSDTQELTYAELNSRANQIASVLQRKGVGPD
                     RVVALLTGRTPELIAGMLGILKAGGAYLPIASDLPVERIAYMLSDSGAALLLQSEKTEK
                     QLLDIACEQFIIEDIQKQGETKNFESSAGAHSLAYIIYTSGSTGKPKGVMIEQRSVIRL
                     VKNSNYITFTPADRLLMTSSIGFDVVTFEIFAPLLNGAALHLSDKQVFLDSYQLQRYIE
                     HHGITTMWLTSSLFNHLTEQNETIFSQLNHLIIGGEALSASHVNRIRNVCPEVSIWNGY
                     GPTENTTFSTCFHIQKTYELSIPIGRPVGNSTAYILDKWGMLQPVGTVGELCVGGDGVA
                     RGYLGRPDLTKEKFVPNPFAPGDRLYRTGDLARWLPDGTIEYVGRIDDQVKVR"
     aSModule        421..3534
                     /complete
                     /domains="nrpspksdomains_MOE71_RS22310_AMP-binding.1"
                     /domains="nrpspksdomains_MOE71_RS22310_PCP.1"
                     /domains="nrpspksdomains_MOE71_RS22310_Epimerization.1"
                     /domains="nrpspksdomains_MOE71_RS22310_TIGR01720.1"
                     /locus_tags="MOE71_RS22310"
                     /monomer_pairings="X -> D-X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       607..645
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0002"
                     /evalue="1.60E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="214"
                     /protein_start="201"
                     /score="15.0"
                     /tool="antismash"
                     /translation="LGILKAGGAYLPI"
     CDS_motif       832..888
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0003"
                     /evalue="1.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="295"
                     /protein_start="276"
                     /score="33.4"
                     /tool="antismash"
                     /translation="AYIIYTSGSTGKPKGVMIE"
     CDS_motif       1393..1482
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0004"
                     /evalue="7.80E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="493"
                     /protein_start="463"
                     /score="56.5"
                     /tool="antismash"
                     /translation="PVGTVGELCVGGDGVARGYLGRPDLTKEKF"
     CDS_motif       1564..1629
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0005"
                     /evalue="1.70E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="542"
                     /protein_start="520"
                     /score="39.1"
                     /tool="antismash"
                     /translation="YVGRIDDQVKVRGYRVELGEIE"
     aSDomain        1915..2118
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22310_PCP.1"
                     /evalue="1.00E-24"
                     /label="MOE71_RS22310_PCP.1"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="705"
                     /protein_start="637"
                     /score="78.5"
                     /tool="antismash"
                     /translation="EEQLALIWQEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRHGL
                     SLQVSDLFRHPKIKDLSPFIRKT"
     aSDomain        2149..3054
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22310_Epimerization.1"
                     /evalue="2.00E-164"
                     /label="MOE71_RS22310_Epimerization.1"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="1017"
                     /protein_start="715"
                     /score="540.3"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDG"
                     /tool="antismash"
                     /translation="GDVPWTPVQQWFLSQDIEERHHFNQSVMLFHSDRLSEEALRAALK
                     KLAEHHDALRMVYRNDDGRWIQINQGIQESQLYSLRISDLSQSESGWETQIKQEVADLQ
                     QSINLQEGPLLHAAWFKTLTGDYLFLAIHHLVVDGVAWRILLEDLSAGYQQASSGQVIQ
                     LPPKTDSYQEYARRIQEYAQSSRLIREEVYWRSVEEQQAAELPYEMPLHEKTDFSRRDS
                     IRFSLSEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGREHIL
                     PELDISRTVGWFTSMYPALIS"
     CDS_motif       2248..2325
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0006"
                     /evalue="1.80E-05"
                     /label="C2_LCL_024-062"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="774"
                     /protein_start="748"
                     /score="17.1"
                     /tool="antismash"
                     /translation="RLSEEALRAALKKLAEHHDALRMVYR"
     CDS_motif       2530..2595
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0007"
                     /evalue="3.00E-11"
                     /label="NRPS-E2"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="864"
                     /protein_start="842"
                     /score="35.5"
                     /tool="antismash"
                     /translation="LFLAIHHLVVDGVAWRILLEDL"
     CDS_motif       3001..3048
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0008"
                     /evalue="5.60E-09"
                     /label="NRPS-E5"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="1015"
                     /protein_start="999"
                     /score="27.9"
                     /tool="antismash"
                     /translation="DISRTVGWFTSMYPAL"
     aSDomain        3073..3534
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22310_TIGR01720.1"
                     /evalue="1.00E-52"
                     /label="MOE71_RS22310_TIGR01720.1"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="1177"
                     /protein_start="1023"
                     /score="170.0"
                     /tool="antismash"
                     /translation="ELGTAVKTVKDTLGRIPNKGVGYGMLKYLTHPENKSITFSKTPDI
                     SFNYLGQFNDIERQDSFRPSSLGSGKDITHTWKREQIIEMSAMAADKKLHFNLSYPPAL
                     FHRNTMEQLINRIEHFLRDIMKHCAGKQKAEKTLSDFSSQSLTAEDLDSI"
     CDS_motif       3097..3159
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22310_0009"
                     /evalue="1.10E-09"
                     /label="NRPS-E6"
                     /locus_tag="MOE71_RS22310"
                     /protein_end="1052"
                     /protein_start="1031"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VKDTLGRIPNKGVGYGMLKYL"
     aSDomain        3580..3669
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22315_NRPS-COM_Nterm.1"
                     /evalue="1.90E-18"
                     /label="MOE71_RS22315_NRPS-COM_Nterm.1"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="30"
                     /protein_start="0"
                     /score="57.4"
                     /tool="antismash"
                     /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDS"
     gene            3580..>9458
                     /locus_tag="MOE71_RS22315"
                     /old_locus_tag="MOE71_22260"
     CDS             3580..>9458
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (0-30). E-value: 1.9e-18.
                     Score: 57.4. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22315_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (7-304). E-value:
                     3.8e-118. Score: 385.9. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22315_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (468-865). E-value:
                     3.1e-104. Score: 340.7. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22315_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (971-1040). E-value: 2.5e-23. Score:
                     74.0. Matches aSDomain: nrpspksdomains_MOE71_RS22315_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1054-1333). E-value:
                     1e-102. Score: 335.1. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22315_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1499-1900). E-value:
                     3.7e-110. Score: 360.3. Matches aSDomain:
                     nrpspksdomains_MOE71_RS22315_AMP-binding.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389713.2"
                     /locus_tag="MOE71_RS22315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MOE71_22260"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_268274530.1"
                     /sec_met_domain="PP-binding (E-value: 3.7e-17, bitscore:
                     49.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 4.5e-89, bitscore:
                     285.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-119, bitscore:
                     385.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGKV
                     NSQFFQNSINALVARHDIFRTIFISQNVSSPQQVVLRERNIIVQEKDITHLNEEKQAQF
                     IEQLKEKDRAQGFHLQKDMLMRIALIQTGESQYTCIWTFHHIMMDGWCLSIVLKEFLHI
                     YASYVNATPISLEPVQPYGSYIKWLMEQDKEQAVSYWEHYLSGHEQQTMLPKQKKTKGR
                     SRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGSVISGR
                     PAEIEGIEHMVGLFINTIPIRVQGAKTPFIQLIKDMQKDRLAAEAYSYHPLYEIQARSA
                     VKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLMVAPGEEI
                     HIKMSYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIEIMTDTEKRQLIGEIADR
                     TPVYETIHAMFEKQAEKTPDAHAVIDQACTLTYKELNKSANRLARHLRMKGVARQEPVA
                     IMMERSAALITGVLGILKAGGAIVPIDPHYPADRIRYILNDCGCSHVVSQAHLSASLDN
                     NYLITHAEDIESTEDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEHRNMANLLKFEF
                     AHSGIDFEADVLQFATPAFDVCYQEIFSALLKGGTLHIVPEAIKRDVPQLFAFINKHQT
                     NIVFFPTAFIKMIFSERQLANSFPYGVKHLITAGEQLIISDIFQDVLRERGIHLHNHYG
                     PSETHVVSTYTIHPGDPIPEFPPIGKPIGCTDLYILNHQKQLQPCGVPGELYISGASVA
                     RGYVNQDKLTRDKFSSDPFRPGAIMYRTGDLARRLGDGNIEYIGRADNQVKIRGYRIEP
                     QEIEVTLMNHPDIKEAAILISQDQNGEHELCAYYCSIQKLNAIDLRSYMASELPEYMIP
                     TKWIWVDSIPLTPNGKVDQAALPAPDASIIGNPYAAPRNLIEAKLSQIFEDVLKNGHIG
                     IQDNFFDHGGHSLKATVLMSRIAKEFHVQVPLQDIFAHPTVEGLASIIRDAEQNPYAAI
                     EPAEERKTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEGALDVAKLSAVCKELISRHE
                     PLRTSFVSGADGEPVQRIHTEVPFTLSTETAIEGFIRSFDLSQAPLFRAGLIKVTNEKH
                     VLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQYKDYAVWQQQFKKGDSYQKQE
                     TYWQKQFSGDLPALELPTDKRRPAERHFTGGKATFQLDKEITARIKRLANKNRSTLYMT
                     LLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVLGMFVNTLALRTRPAGNMTFEEFL
                     KEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNPLFDTTLVLQNMEQQKLKMKDVQLR
                     WNDLQHPISKFDISLYVTEHDSELFCQFEYSTALFEKETIQRWAGLFTTLVEHTAVSPK
                     TELDDIPLLTKEEERAFIESCHPFQETGYPMNQTLHYALEQQAAKTPDQPAVIFEHGAM
                     TYKELNEQANRIAWELIGRGVKSETTVAIIGKRSPEMLIGIYGILKAGGAYLPIDPDYP
                     EERISFLLEDSGTDILLLQSSSLHVPAFAGEIVYLNQANSGLKHRLSNPNVDVLPKSLA
                     YVIYTSGSTGRPKGVEVEHRSAVNFLNSLQCRYRLKQSDVIMHKTSYSFDASIWELFWW
                     PYAGASVYLLPQGGEKEPEVIAKAVEEQEITAMHFVPSMLHAFLEHIKYRPVPIKINGL
                     KRVFSGGEQLGTHLVSRFCELLPGVALTNSYGPTEATVEAAFFDCPLHEKLERVPIGKS
                     VHHVRLYILNQKQRMLPAGCIGELYIAGAGVARGYLNRPALTKERFLEDPFYPGERMYK
                     TGDLARWLPDGHVEFLGRLDDQVKIRGYRIEPGEIEAALRSIEGIREAAVTVRTDSGEP
                     ELCAYTEGLRRNEVRTQLERLLPGYM"
     aSDomain        3601..4491
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22315_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="3.80E-118"
                     /label="MOE71_RS22315_Condensation_DCL.1"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="304"
                     /protein_start="7"
                     /score="385.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIMMDG"
                     /tool="antismash"
                     /translation="QDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGKVNSQFFQN
                     SINALVARHDIFRTIFISQNVSSPQQVVLRERNIIVQEKDITHLNEEKQAQFIEQLKEK
                     DRAQGFHLQKDMLMRIALIQTGESQYTCIWTFHHIMMDGWCLSIVLKEFLHIYASYVNA
                     TPISLEPVQPYGSYIKWLMEQDKEQAVSYWEHYLSGHEQQTMLPKQKKTKGRSRQEHVT
                     FSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGSVISGRPAEIEGI
                     EHMVGLFINTIPIRVQ"
     aSModule        3601..6699
                     /complete
                     /domains="nrpspksdomains_MOE71_RS22315_Condensation_DCL.1"
                     /domains="nrpspksdomains_MOE71_RS22315_AMP-binding.1"
                     /domains="nrpspksdomains_MOE71_RS22315_PCP.1"
                     /locus_tags="MOE71_RS22315"
                     /monomer_pairings="Pro -> Pro"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       3610..3651
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0001"
                     /evalue="9.10E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="24"
                     /protein_start="10"
                     /score="14.5"
                     /tool="antismash"
                     /translation="YPLSYMQEGMLFHS"
     CDS_motif       3673..3786
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0002"
                     /evalue="1.20E-14"
                     /label="C2_DCL_024-062"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="69"
                     /protein_start="31"
                     /score="46.5"
                     /tool="antismash"
                     /translation="AYVEQASFTIEGKVNSQFFQNSINALVARHDIFRTIFI"
     CDS_motif       4006..4071
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0003"
                     /evalue="5.20E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="164"
                     /protein_start="142"
                     /score="34.9"
                     /tool="antismash"
                     /translation="FHHIMMDGWCLSIVLKEFLHIY"
     CDS_motif       4117..4155
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0004"
                     /evalue="2.20E-02"
                     /label="C4_DCL_171-183"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="192"
                     /protein_start="179"
                     /score="7.9"
                     /tool="antismash"
                     /translation="PYGSYIKWLMEQD"
     CDS_motif       4390..4485
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0005"
                     /evalue="8.70E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="302"
                     /protein_start="270"
                     /score="63.1"
                     /tool="antismash"
                     /translation="DAVFGSVISGRPAEIEGIEHMVGLFINTIPIR"
     CDS_motif       4531..4647
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0006"
                     /evalue="1.10E-20"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="356"
                     /protein_start="317"
                     /score="66.1"
                     /tool="antismash"
                     /translation="QKDRLAAEAYSYHPLYEIQARSAVKQGLIDHILVFENYP"
     aSDomain        4984..6174
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22315_AMP-binding.1"
                     /evalue="3.10E-104"
                     /label="MOE71_RS22315_AMP-binding.1"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="865"
                     /protein_start="468"
                     /score="340.7"
                     /specificity="substrate consensus: Pro"
                     /tool="antismash"
                     /translation="FEKQAEKTPDAHAVIDQACTLTYKELNKSANRLARHLRMKGVARQ
                     EPVAIMMERSAALITGVLGILKAGGAIVPIDPHYPADRIRYILNDCGCSHVVSQAHLSA
                     SLDNNYLITHAEDIESTEDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEHRNMANLL
                     KFEFAHSGIDFEADVLQFATPAFDVCYQEIFSALLKGGTLHIVPEAIKRDVPQLFAFIN
                     KHQTNIVFFPTAFIKMIFSERQLANSFPYGVKHLITAGEQLIISDIFQDVLRERGIHLH
                     NHYGPSETHVVSTYTIHPGDPIPEFPPIGKPIGCTDLYILNHQKQLQPCGVPGELYISG
                     ASVARGYVNQDKLTRDKFSSDPFRPGAIMYRTGDLARRLGDGNIEYIGRADNQVKIR"
     CDS_motif       5170..5211
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0007"
                     /evalue="2.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="544"
                     /protein_start="530"
                     /score="14.3"
                     /tool="antismash"
                     /translation="LGILKAGGAIVPID"
     CDS_motif       5395..5451
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0008"
                     /evalue="1.40E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="624"
                     /protein_start="605"
                     /score="26.9"
                     /tool="antismash"
                     /translation="YMIYTSGTTGKPKGVQFEH"
     CDS_motif       5833..5859
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0009"
                     /evalue="4.40E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="760"
                     /protein_start="751"
                     /score="4.1"
                     /tool="antismash"
                     /translation="YGPSETHVV"
     CDS_motif       5968..6057
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0010"
                     /evalue="1.80E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="826"
                     /protein_start="796"
                     /score="42.6"
                     /tool="antismash"
                     /translation="PCGVPGELYISGASVARGYVNQDKLTRDKF"
     CDS_motif       6139..6204
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0011"
                     /evalue="6.40E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="875"
                     /protein_start="853"
                     /score="37.4"
                     /tool="antismash"
                     /translation="YIGRADNQVKIRGYRIEPQEIE"
     aSDomain        6493..6699
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22315_PCP.1"
                     /evalue="2.50E-23"
                     /label="MOE71_RS22315_PCP.1"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1040"
                     /protein_start="971"
                     /score="74.0"
                     /tool="antismash"
                     /translation="EAKLSQIFEDVLKNGHIGIQDNFFDHGGHSLKATVLMSRIAKEFH
                     VQVPLQDIFAHPTVEGLASIIRDA"
     aSDomain        6742..7578
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22315_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.00E-102"
                     /label="MOE71_RS22315_Condensation_LCL.1"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1333"
                     /protein_start="1054"
                     /score="335.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDG"
                     /tool="antismash"
                     /translation="KTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEGALDVAKLSAVC
                     KELISRHEPLRTSFVSGADGEPVQRIHTEVPFTLSTETAIEGFIRSFDLSQAPLFRAGL
                     IKVTNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQYKDYAVWQQQFKK
                     GDSYQKQETYWQKQFSGDLPALELPTDKRRPAERHFTGGKATFQLDKEITARIKRLANK
                     NRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVLGMFVNTLALRTRP"
     aSModule        6742..9279
                     /domains="nrpspksdomains_MOE71_RS22315_Condensation_LCL.1"
                     /domains="nrpspksdomains_MOE71_RS22315_AMP-binding.2"
                     /incomplete
                     /locus_tags="MOE71_RS22315"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6808..6921
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0012"
                     /evalue="6.90E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1114"
                     /protein_start="1076"
                     /score="47.4"
                     /tool="antismash"
                     /translation="AYNMPAVLELEGALDVAKLSAVCKELISRHEPLRTSFV"
     CDS_motif       7093..7158
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0013"
                     /evalue="1.80E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1193"
                     /protein_start="1171"
                     /score="30.1"
                     /tool="antismash"
                     /translation="MHHIISDGVSVQLLIREFTDLY"
     CDS_motif       7189..7221
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0014"
                     /evalue="9.80E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1214"
                     /protein_start="1203"
                     /score="11.9"
                     /tool="antismash"
                     /translation="QYKDYAVWQQQ"
     CDS_motif       7480..7569
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0015"
                     /evalue="2.60E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1330"
                     /protein_start="1300"
                     /score="51.9"
                     /tool="antismash"
                     /translation="DIVIGSPIAGRPHADLEAVLGMFVNTLALR"
     CDS_motif       7618..7737
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0016"
                     /evalue="6.40E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1386"
                     /protein_start="1346"
                     /score="66.8"
                     /tool="antismash"
                     /translation="RQTALEAYEHQDYPFEELVDKLGVQREMSRNPLFDTTLVL"
     aSDomain        8077..9279
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MOE71_RS22315_AMP-binding.2"
                     /evalue="3.70E-110"
                     /label="MOE71_RS22315_AMP-binding.2"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1900"
                     /protein_start="1499"
                     /score="360.3"
                     /specificity="substrate consensus: Glu"
                     /tool="antismash"
                     /translation="LEQQAAKTPDQPAVIFEHGAMTYKELNEQANRIAWELIGRGVKSE
                     TTVAIIGKRSPEMLIGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTDILLLQSSSLH
                     VPAFAGEIVYLNQANSGLKHRLSNPNVDVLPKSLAYVIYTSGSTGRPKGVEVEHRSAVN
                     FLNSLQCRYRLKQSDVIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKA
                     VEEQEITAMHFVPSMLHAFLEHIKYRPVPIKINGLKRVFSGGEQLGTHLVSRFCELLPG
                     VALTNSYGPTEATVEAAFFDCPLHEKLERVPIGKSVHHVRLYILNQKQRMLPAGCIGEL
                     YIAGAGVARGYLNRPALTKERFLEDPFYPGERMYKTGDLARWLPDGHVEFLGRLDDQVK
                     IR"
     CDS_motif       8266..8304
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0017"
                     /evalue="8.30E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1575"
                     /protein_start="1562"
                     /score="15.9"
                     /tool="antismash"
                     /translation="GILKAGGAYLPID"
     CDS_motif       8491..8550
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0018"
                     /evalue="2.80E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1657"
                     /protein_start="1637"
                     /score="32.0"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVEVEH"
     CDS_motif       8935..8964
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0019"
                     /evalue="4.20E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1795"
                     /protein_start="1785"
                     /score="7.0"
                     /tool="antismash"
                     /translation="SYGPTEATVE"
     CDS_motif       9073..9162
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0020"
                     /evalue="3.20E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1861"
                     /protein_start="1831"
                     /score="57.8"
                     /tool="antismash"
                     /translation="PAGCIGELYIAGAGVARGYLNRPALTKERF"
     CDS_motif       9244..9309
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MOE71_RS22315_0021"
                     /evalue="1.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="MOE71_RS22315"
                     /protein_end="1910"
                     /protein_start="1888"
                     /score="39.7"
                     /tool="antismash"
                     /translation="FLGRLDDQVKIRGYRIEPGEIE"
ORIGIN
        1 gaagagctcg tcgacaagct taaattgacg cgggatatga gccggaatcc gctgtttgac
       61 gtgatgtttg ttcttcaaaa tatggatcag gaatcgattc agcttgaaga actgcatctc
      121 aaacctgcag caaacaacgg gcatcaaacg tccaaatttg atttaactct gtatgctcac
      181 gaacagccct gcggtttgct gacgttccaa atggaattta gtacggactt atataagaaa
      241 aaaacgatag aaaagtggct tcaatacttc atcaatatgt tactctccat cacccaagac
      301 aacaaagccg ctctcggaac aataaatata ctaaatgagg atgagaccca ttaccttatc
      361 catgagctca atcgtacaaa aatagattat ccaagaaatg aaaccatcag caggctcttt
      421 gaaatgcagg ctgaacaaac acctaatgcc attgcaattg tcagcgatac acaagaatta
      481 acttacgcgg aactgaacag ccgggcaaat caaattgctt cagttctaca gagaaaggga
      541 gtaggacctg atcgtgttgt agccttgttg acaggacgaa cgccagaact catagcggga
      601 atgctgggca ttctgaaagc cgggggagcc tatcttccta tagcttctga cctgcctgtt
      661 gaacgaatag cttatatgct gtcagacagc ggggcggcat tactccttca atctgaaaaa
      721 acagaaaaac agctattaga cattgcatgt gaacaattca taatcgaaga cattcaaaag
      781 caaggagaaa cgaagaactt tgaatcgtca gcaggggcac actcacttgc atatatcatt
      841 tatacctctg gatcaaccgg taaaccaaag ggtgtcatga ttgagcagcg aagtgtcatt
      901 cgtcttgtta aaaacagcaa ttatattaca tttacacctg cagaccgtct tctcatgaca
      961 tcatcaatcg gttttgatgt tgtgacattt gaaatatttg caccgctgct aaatggggca
     1021 gctttgcacc tgtccgataa acaagtattt ctcgattcct atcagcttca gagatacata
     1081 gaacatcatg ggatcacaac gatgtggctg acatcttctc tattcaatca tttgacagag
     1141 cagaatgaga caatattttc acagctgaac catctgatta taggcgggga agccttgtcc
     1201 gcaagccacg tcaatcgaat ccgaaatgtc tgcccggaag tatcgatatg gaacggatat
     1261 ggaccaaccg aaaatacaac tttttcgaca tgcttccaca ttcaaaaaac atatgaactt
     1321 tccattccga tcgggcggcc ggttggtaat tccactgctt atatcttaga taaatgggga
     1381 atgctgcagc cggtcggaac tgtcggtgaa ctttgtgtcg gcggtgatgg cgtcgccaga
     1441 ggctatttag gccgtcctga tttaacaaaa gagaaatttg tcccaaatcc atttgcgcct
     1501 ggcgatcgac tgtaccgcac aggtgatctg gcgcgttggc ttcccgatgg cacaattgag
     1561 tacgttggcc gtatagatga tcaagtaaaa gtcagaggct atcgggtgga gctgggggag
     1621 atcgaatcag cacttcgcca aatagacggg gtcaaagaag ccgctgtgtt ggcacgtaca
     1681 ggccagacgg ggagcaaaga gctgtttggc tacatcagcg taaatgcagg cacgaatgct
     1741 gaacaagtgc gttctcttct cgcgcgttca ctgccaaatt atatgatccc ggcgtacatc
     1801 attgaaatgg agactcttcc gctcacatca aacggcaaat tgaaccggaa agcacttcct
     1861 gaaccagatt tcgcatctaa acaaatgtac gtcccgccac gcgatgacct tgaagaacag
     1921 ctggcattga tctggcagga ggttctcggc atccagagga tcggaataga ggattcgttt
     1981 tttgaattgg gcggagattc aatcaaagcg cttcaagttt ctgcacgcct tggacgccat
     2041 gggctaagct tgcaggtaag tgatttattc cggcatccaa agataaaaga cttatcacca
     2101 tttatccgta agacagagag aattatagaa caaggcccca ttcagggaga cgttccttgg
     2161 acgcctgttc agcaatggtt tctttcacaa gatattgaag aacgacacca ttttaatcag
     2221 tctgtcatgc ttttccattc tgaccgtttg tctgaagaag cccttagagc agccttgaaa
     2281 aaactggcgg agcatcatga tgcgcttcgg atggtttatc gtaacgatga cgggcgatgg
     2341 attcaaatca accaaggcat tcaggaatca cagctgtaca gtttaagaat atctgatctt
     2401 tcacagtccg aaagcggttg ggaaacgcaa atcaaacaag aagttgcaga tcttcagcaa
     2461 agcatcaatt tgcaggaagg accattgtta catgccgcgt ggtttaaaac actgacagga
     2521 gattacttgt tccttgcgat ccatcatctt gtcgttgacg gtgtggcatg gcggattttg
     2581 ctggaggatt tgtcagcagg gtaccaacaa gcatcttcag gccaagtgat ccagcttccg
     2641 cctaaaactg attcctatca ggaatacgca agacggatac aggaatatgc ccaaagcagc
     2701 aggctgattc gtgaagaggt gtattggcga agtgtggaag aacagcaagc tgcggaactg
     2761 ccatatgaaa tgccgcttca tgagaagacc gacttcagca gaagggattc gatacgcttt
     2821 tcactctctg aagcagacac tgccgttttg ctgcaaaacg tcaatcatgc ctatggtaca
     2881 gatacacaag atattctgtt aaccgcagca tccttggcga tttgtgaatg gacaggcgga
     2941 agcaagctcc gtatcgctat ggaaggacac gggagagaac acattctgcc agagttagat
     3001 atcagccgaa cggtcggctg gtttacatcc atgtacccgg cactcataag ctttgaaaat
     3061 catagggatg agctcggaac cgcagtaaaa accgttaaag atacactggg ccggatacca
     3121 aacaaagggg taggttacgg tatgctgaaa taccttacac accctgaaaa caaaagcatt
     3181 acgttttcaa aaacacctga catcagcttt aactatttgg gccagttcaa cgacatcgaa
     3241 agacaggaca gcttccgccc atcaagtctt gggagcggaa aggatatcac tcatacatgg
     3301 aagcgtgagc aaatcatcga gatgagtgca atggcagcag acaaaaagct ccatttcaat
     3361 cttagttatc cgccagccct ctttcataga aacacaatgg aacagcttat caacaggatt
     3421 gaacactttt tgcgggacat tatgaaacat tgcgccggta aacagaaagc agaaaagaca
     3481 ctgagcgatt ttagcagtca atcattaacg gcagaggatt tggacagcat atccagcttg
     3541 gtggaagaat tgtagaaaat cggacaggga gacatgaaca tgacaaaagc gaattcaatt
     3601 caggatattt atccgctgtc ttacatgcag gaagggatgc ttttccattc cctcctgcaa
     3661 aaagattcac aggcatatgt tgagcaagct tcttttacaa tagaaggaaa agtaaactca
     3721 cagttttttc aaaacagcat caacgctctt gtagcaagac acgatatttt cagaacgatt
     3781 tttatcagcc aaaatgtttc ctctccccag caggttgtcc tgagagaacg gaacatcatc
     3841 gtacaggaaa aagacattac tcatttaaac gaagagaagc aagcacagtt tatcgaacaa
     3901 ttgaaagaaa aagaccgcgc ccaagggttt cacttgcaaa aggatatgct catgcgcatc
     3961 gctctgattc aaacaggtga gagtcagtac acttgtattt ggacctttca tcacatcatg
     4021 atggacggat ggtgcctcag cattgtgcta aaggagtttc tccatattta cgcatcttat
     4081 gtaaatgcca cccctatatc attggagccg gtccagccat acggaagcta tatcaaatgg
     4141 ctgatggagc aagacaaaga gcaggcagtt tcatattggg aacattatct ttccggccat
     4201 gaacagcaaa ccatgctccc gaagcagaaa aaaacaaagg ggagaagcag gcaggaacac
     4261 gttacgtttt cattctctaa ggaagaaagc agcaggcttt cggagcttgc ggcaagagaa
     4321 gaagtaacac tcagtacgat tttccatacc atttggggta ttctgcttca aaaatataat
     4381 aataacgatg acgcggtatt cggttctgtc atttcaggaa gacccgcaga aatcgaaggc
     4441 attgaacata tggtaggtct tttcattaac acgataccga ttcgggtgca gggggcaaaa
     4501 acaccattta tacagctcat aaaagatatg caaaaagacc gtcttgccgc tgaagcatac
     4561 agctaccacc ctttatatga gattcaagcc cgttcagctg ttaaacaagg gctgattgat
     4621 catattctcg tatttgaaaa ctatccggtt cagcaagaga ttcagatgct gaacaagcag
     4681 gaacatgctt ctgatctttt tcagattcat aacttcactg tggcagatga aaccaactac
     4741 agcttttatc ttatggtggc gccaggggaa gaaatccata tcaaaatgag ctatgatgcg
     4801 gagcagcatg atcggtcttt tgtgctttct gtcaaggagc atcttctgaa tgctgtatca
     4861 caaatcttaa ataatccgaa tcttccgcct gaagaaatcg agatcatgac agatactgaa
     4921 aagcggcagc tgattgggga aatcgcggat cgaacgccag tttacgaaac catccatgcg
     4981 atgtttgaaa aacaagcgga aaagacccca gatgctcatg cagtaattga tcaagcctgc
     5041 acgttaacat acaaagaact gaataaatcg gctaacagat tggcgcggca tttgcgaatg
     5101 aagggtgttg cgaggcagga gcctgttgcg atcatgatgg aacgctctgc ggcattgatc
     5161 accggggttc ttggtatctt gaaagcaggc ggcgccatag ttccaattga tccgcattac
     5221 ccggctgaca gaatccgtta tattctaaat gactgcggct gttcgcatgt tgtttcacaa
     5281 gctcatcttt ccgcatcgct tgataacaat taccttatca ctcatgcaga agatattgaa
     5341 agcacagaag acggcagtaa cataaagtca gttaacaatg cggacgatct gctgtatatg
     5401 atttatacat caggtacaac aggtaaacca aagggcgttc aatttgaaca tcgaaacatg
     5461 gctaacttgc tgaagttcga atttgctcac tctgggattg actttgaagc agatgttctg
     5521 caatttgcga cacctgcctt tgacgtctgt tatcaagaaa tattttctgc gcttctgaaa
     5581 ggcggcaccc tgcacatcgt gccagaagcc ataaaaagag atgtgcctca gctgtttgca
     5641 tttataaaca agcatcagac gaatattgtg tttttcccaa cggcttttat caaaatgatt
     5701 ttcagcgagc ggcaacttgc gaactcgttt ccttatggcg tcaaacactt gattacagct
     5761 ggggaacaat taattatttc agacattttc caagacgtgt tacgtgaacg cggcatacac
     5821 ctgcacaatc attacggacc ttcagaaact catgtggtat ctacgtacac cattcatccg
     5881 ggagacccta ttcctgagtt tccgccaatc ggtaaaccga taggctgtac tgatttatat
     5941 attttgaatc accaaaaaca gctacagcca tgcggtgtac caggtgaact ctatatttcc
     6001 ggcgcaagtg ttgccagagg atatgtcaat caagataaac tgacacgcga caaattttca
     6061 tccgacccat tcaggcctgg tgcgatcatg tatcgtacag gtgatttggc cagacggctt
     6121 ggagacggca acatcgaata tataggacgg gcagacaatc aagtgaaaat cagaggttat
     6181 cgaatcgagc cgcaagaaat cgaagtcacg ttaatgaatc atccggacat taaagaggct
     6241 gccattctca tcagtcaaga tcaaaacgga gaacatgaat tatgcgctta ctattgcagt
     6301 atacaaaagc tgaatgcaat agatttacgc agctatatgg ctagtgagct gccagaatac
     6361 atgattccca cgaaatggat atgggttgac agcatacctc ttaccccaaa cggaaaagta
     6421 gatcaagcag cgcttccagc gccagatgct tcaatcatcg gaaatccata tgctgcccct
     6481 cgtaatctga tagaggcaaa gctttcacaa atatttgaag atgtgctgaa gaatggtcat
     6541 ataggcatcc aagacaactt ttttgaccat ggaggccact ctctaaaagc aacagtactg
     6601 atgtcacgga tcgcaaagga atttcatgta caagttccgc ttcaggacat ctttgcccat
     6661 ccgactgtag aagggttggc ttcaatcatt cgagatgcag agcaaaatcc gtatgcagca
     6721 attgagccgg cagaagaaag gaagacatat cctgtatctt cggcacaaaa acggatatat
     6781 gtgcttcagc agcttgatga gggtgtcgcc tacaatatgc ctgcggtctt agaactggaa
     6841 ggggcactgg atgtcgctaa actgtctgct gtatgtaaag aactgatcag ccggcatgag
     6901 cctcttcgaa cttcctttgt atccggggca gatggcgagc ctgttcagcg tatccacacc
     6961 gaagtgccgt ttacattaag tacagagacc gctatcgagg ggtttatccg ctcctttgat
     7021 ctcagccagg cgccattatt tagagcgggc cttataaaag tgacgaacga gaagcatgta
     7081 ttgctggtgg atatgcacca tatcatttca gatggcgtat ccgttcagct cctaatccga
     7141 gaattcaccg atctttatgc aaaccggcag cttaagccat tgcggatcca gtataaagat
     7201 tacgccgtct ggcagcagca atttaaaaag ggagactcgt accaaaagca ggagacttac
     7261 tggcagaagc agtttagcgg ggaccttcct gcgctagagc ttccgacaga taaacgccgc
     7321 ccggcagaac ggcactttac aggcggaaaa gcaacctttc aattggataa agagatcaca
     7381 gcccgcataa agcggcttgc caataaaaac agaagcacgc tttatatgac gcttcttgct
     7441 ttgtattcag cctttttgtc gcggttaagc ggtcaggatg atatcgtaat tggttcacct
     7501 atcgccggac ggccccatgc cgaccttgaa gctgttcttg ggatgttcgt caatacattg
     7561 gctctccgca cacgcccggc cggtaatatg acatttgaag agtttctgaa agaagtcaga
     7621 cagacagcat tagaagcgta tgagcatcag gattacccgt ttgaagagct tgtggataaa
     7681 ctcggtgtgc agcgggaaat gagccggaat ccattgtttg acacaacgct agtccttcag
     7741 aatatggaac agcaaaagct gaaaatgaaa gatgtacaac ttcgatggaa cgatttgcag
     7801 catccaatat cgaaatttga tatttctctg tatgttacag aacacgattc cgagcttttc
     7861 tgtcagtttg aatacagtac agctttgttt gagaaagaaa ccatccaaag gtgggccggc
     7921 cttttcacca cgcttgtgga acatacagct gtcagcccta aaacagaatt ggacgatatt
     7981 ccactcttaa caaaagaaga agagagagct ttcattgaat catgccatcc gtttcaggag
     8041 acgggctatc cgatgaatca aactctccac tatgcacttg aacagcaggc agcaaaaacg
     8101 cctgatcagc cggccgttat ctttgaacat ggagcgatga cctataaaga gttgaacgaa
     8161 caggctaacc gtatcgcctg ggagctgatc ggacgaggag taaaatctga aacgactgtt
     8221 gccattatag gaaagcgttc gcctgaaatg ctgattggca tttatggcat tcttaaagct
     8281 ggcggcgctt atcttcctat tgacccggat tacccggaag aacgaatcag ctttctgctg
     8341 gaggacagcg gtacagacat tctcctgctt cagtcttcca gcctgcatgt tccggcattt
     8401 gcaggagaga ttgtctacct caatcaggca aatagcggac tgaaacatcg tttgtccaat
     8461 ccgaatgtgg acgttctccc taaatcttta gcctatgtca tctatacatc cggctctacc
     8521 ggcaggccta agggtgtgga agttgaacat cgatctgcgg tgaatttttt gaattccctt
     8581 cagtgccgct atcggctgaa gcaatcagat gtgattatgc ataaaacatc ttactcattt
     8641 gacgcttcca tatgggagct gttttggtgg ccttatgccg gtgcttctgt ttatctgctt
     8701 cctcagggag gggaaaaaga acctgaagtg atcgcgaagg ctgtagaaga acaagagatc
     8761 acagctatgc attttgtgcc atctatgctt catgcatttt tagaacatat aaaatatcgc
     8821 cctgtaccga ttaaaataaa cggactcaaa cgggtgtttt ccgggggaga acagctgggg
     8881 acccatctcg tctcccgttt ttgcgagtta cttccaggtg ttgcattaac caattcttac
     8941 ggaccaacgg aggcaactgt agaagctgcg ttctttgatt gtccgctgca tgaaaagctt
     9001 gaacgcgttc caattggaaa atctgttcat catgtcagat tgtatatcct caatcagaag
     9061 cagcggatgc tgcctgctgg atgtatcgga gaactgtaca ttgccggagc gggtgttgcc
     9121 agaggctatt tgaatcggcc agccttaacg aaggagcgtt ttctagagga cccgttttac
     9181 ccgggtgaac gcatgtacaa aaccggggat ttggcgcgct ggcttcctga cggacatgtt
     9241 gaattcctcg gccgtttgga tgatcaagtc aaaatcaggg gctaccgtat cgagcctgga
     9301 gaaattgaag cagcgcttag aagcattgaa ggcatcagag aggcagccgt taccgtacgg
     9361 acagacagcg gcgagccgga attatgcgcc tatacagaag gactaagaag aaacgaagtg
     9421 cggacgcagc ttgagagact tttaccggga tacatgat
//
