LOCUS       NZ_JAKVIE010000017     22542 bp    DNA     linear   CON 23-JAN-2024
DEFINITION  Streptococcus pasteurianus strain D17293137
            D17293137_S20_contig_17_consensus, whole genome shotgun sequence.
ACCESSION   NZ_JAKVIE010000017
VERSION     NZ_JAKVIE010000017.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pasteurianus
  ORGANISM  Streptococcus pasteurianus
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 28567)
  AUTHORS   Christensen,J., Jensen,C., Dargis,R., Nielsen,X., Pries- Heje,M.,
            Wiingaard,C., Ihlemann,N., Gill,S., Bruun,N., Elming,H., Povlsen,J.,
            Madsen,T., Jensen,K., Fuursted,K., Ostergaard,L., Christiansen,U.,
            Rosenvinge,F., Helweg-Larsen,J., Fosbol,E., Kober,L.,
            Torp-Pedersen,C., Tonder,N., Moser,C., Iversen,K. and Bundgaard,H.
  TITLE     Genomic identification of streptococcal strains and relation to
            clinical characteristics. A substudy to The Partial Oral Treatment
            of Endocarditis (POET) Trial
  JOURNAL   Med Res Arch 10 (9) (2022) In press
  REMARK    DOI: 10.18103/mra.v10i9.3037
REFERENCE   2  (bases 1 to 28567)
  AUTHORS   Christensen,J.J.E., Jensen,C.S., Nielsen,X.C. and Dargis,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-FEB-2022) Department of Clinical Microbiology, Region
            Zealand, Ingemannsvej 46, Slagelse 4200, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72.66x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/23/2024 02:09:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,313
            CDSs (total)                      :: 2,260
            Genes (coding)                    :: 2,168
            CDSs (with protein)               :: 2,168
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 46
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 38 of 92
            Pseudo Genes (incomplete)         :: 58 of 92
            Pseudo Genes (internal stop)      :: 34 of 92
            Pseudo Genes (multiple problems)  :: 30 of 92
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:47:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 22542
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAKVIE010000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22542
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22542
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22542
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6507:12542](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6508..12542
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            34..1407
                     /locus_tag="MK857_RS08310"
                     /old_locus_tag="MK857_08275"
     CDS             34..1407
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719507.1"
                     /locus_tag="MK857_RS08310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08275"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000719507.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.3e-39, bitscore:
                     124.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIGLLSNVFISLFIVILASGSVSSGVSANENKEISYNVLVSEN
                     KSIEDVEDVLQSQGIKVTDKIPEINFLTISTEKSEDTIKKENSNYIDDIVIDNTMTVKP
                     NITYLYGDKVYTNTNLDFWGNQWDMQKSISTGSKFQHKSSGKATIGVIDSGITYDNPDI
                     YSHIISVQNFTSDLETGIVDNQNVVDKIGHGTSVVGQISSSGEYLGIAPDMKIRMYRVF
                     DEGNAQDQWILKALIQAAKDDVDVINLSLGEYLLRDSTDEDDDTALINIYQRAINYAHN
                     QGSVVVASVGDEGMDLQNQDELKNYLGSLRGKDYSQVDGTVQDIPAELDNVVTVGSVDD
                     NDLVSSFSNQGNGDIDIYATGGGSQALSKVGYDKWVADKLYEKEWILVPTLEGKYTYAY
                     GTSISTPKVSAALGLIIEKYNLKDQPDEAIRILYDNCFLSNNGNNGQIRLLNITNFVQ"
     gene            1448..2146
                     /locus_tag="MK857_RS08315"
                     /old_locus_tag="MK857_08280"
     CDS             1448..2146
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276750.1"
                     /locus_tag="MK857_RS08315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08280"
                     /product="response regulator transcription factor"
                     /protein_id="WP_000276751.1"
                     /transl_table=11
                     /translation="MYKILVVDDDFEIVKLMRTILEMKNYNVTTYQEVRLPIKISDFDG
                     FDLILLDVMMPNVDGLQICKQIRKSVSSPIIFVSAKDSEDDIVSGLNLGGDDYITKPFS
                     VNQLVAKVAAHLKREERYRNAESNESVIRELFPLTFYLQEKLVCVNGEAISLTKREYDI
                     LELLSSKTNKVYTREEIYECVYGDEADALFRSISEYIYQIRVKFGPYGINPIKTIRGMG
                     YKWNDEKVFN"
     gene            2124..3467
                     /locus_tag="MK857_RS08320"
                     /old_locus_tag="MK857_08285"
     CDS             2124..3467
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977994.1"
                     /locus_tag="MK857_RS08320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08285"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_000977993.1"
                     /transl_table=11
                     /translation="MMKRYSINKRILRTVLEIVIGTVANVIMLLVLSYVLIFTGQLNTY
                     GTDYHISISDSKSANGIKNQMDYSVFDYVLFDSDNGELVSGNYQKQDLQHYKEVFDTGS
                     SVSEGSILFTKYENSDFILVIRRPTMPEFVNRNFRHISYNLVSYLFFIVLELLLISISV
                     IRLLREFTKNFRLIEKISLNMGIPGMDIGRKETAILECNNILLTLYQKDEELTKLLEME
                     KKDKEDLSFQVAALAHDIKTPLTVLKGNIELLEMTNLDEKQLDFMSSMNHSVGIFEKYF
                     NSMVNYSRLLIEDKNYQEDIELSKFLDELSLECRDIMSSKKINFQIVNESHTRVIKGNR
                     LNLDRALINILSNATRFCSEEGKVVLTISESSNFISFEIWNNGLPFTEESLKDGGKLFY
                     TENKGRNDKHYGIGLSFAQKIAMRHQGQLILSNPQNGGAQVTLLIKKF"
     gene            3657..4358
                     /locus_tag="MK857_RS08325"
                     /old_locus_tag="MK857_08290"
     CDS             3657..4358
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000452012.1"
                     /locus_tag="MK857_RS08325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08290"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000452012.1"
                     /transl_table=11
                     /translation="MEVIIQNLRKSYKDKEVLKDVSFKIEEGTICGLLGVNGAGKSTIM
                     KILFGLERADSGEVIFNGKHKDIVEENRFDIGALIESPAIYLNLSAFDNLKTRALLHDI
                     PDERIYEVLQLVGLSDTGKKKAGHFSLGMKQRLGLGMAIITNPDLLILDEPTNGLDPDG
                     IKELLNLIRDLKKSGMTVLLSSHQLSEVSKIADQIVILNQGKIFYDDINKNSNDLEKLF
                     FRIVHGGDGND"
     gene            4351..5088
                     /locus_tag="MK857_RS08330"
                     /old_locus_tag="MK857_08295"
     CDS             4351..5088
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851902.1"
                     /locus_tag="MK857_RS08330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08295"
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_000181737.1"
                     /transl_table=11
                     /translation="MTNIFKSEWLKQKSSSDKKLLILIPLLAIFIAFILAGPLNLESFS
                     IYWWEGGFLFTLLGLLFLADYSAEENAGAFQNISLGRYTFTIYLAKILLKFKDVLISTF
                     IFTIIFYGISFLFSGVISVDIGKDLICLLLIGVSSAWVLPLLYFLAKWINPYLLLATNS
                     LICLLVAPLIAQTSVWFIFPYTYHYKIAYALLHLKPSGDLEAALSGVEISTILISVSLS
                     ILVFVSFLSLLKWRITNEQNSKK"
     gene            5066..5752
                     /locus_tag="MK857_RS08335"
                     /old_locus_tag="MK857_08300"
     CDS             5066..5752
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033677.1"
                     /locus_tag="MK857_RS08335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08300"
                     /product="hypothetical protein"
                     /protein_id="WP_001033677.1"
                     /transl_table=11
                     /translation="MNKILKSELLKLKGSLTLNLILILSIIQLFTIPLYLQFTNNSVVI
                     ENIIFLPMLGYCILASIFSIFLHEQEEKANFFQNIKSEKNSGIIWGIKLISTDLLMVLL
                     GVPVWIVVGVEFNRLSYFAYVGVITWLLLVLLNHFHMLLSLIMGKGGNLVISFIECLFI
                     IFATNKVFLNNFWLPIVLPVNMILEIGKNEIFMILVYLIGFIILSYFCNLAVMNNVEIQ
                     KICKKR"
     gene            6100..6267
                     /locus_tag="MK857_RS08340"
                     /old_locus_tag="MK857_08305"
     CDS             6100..6267
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058290.1"
                     /locus_tag="MK857_RS08340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08305"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_001058290.1"
                     /sec_met_domain="TIGR03731 (E-value: 7.3e-24, bitscore:
                     74.4, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 5.7e-08, bitscore:
                     22.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNEDFNLDLVTISKENNSGASPRVTSKSLCTPGCKTGILMTCAI
                     KTATCGCHFG"
     CDS_motif       6100..6171
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNEDFNLDLVTISKENNSGASPR"
                     /locus_tag="MK857_RS08340_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6172..6267
                     /prepeptide="core"
                     /locus_tag="MK857_RS08340_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="27.40"
                     /molecular_weight="2989.6"
                     /monoisotopic_mass="2987.5"
                     /core_sequence="VTSKSLCTPGCKTGILMTCAIKTATCGCHFG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNEDFNLDLVTISKENNSGASPR"
                     /leader_location="[6099:6171](+)"
                     /alternative_weights="3007.6"
                     /alternative_weights="3025.7"
                     /alternative_weights="3043.7"
     gene            6508..9483
                     /locus_tag="MK857_RS08345"
                     /old_locus_tag="MK857_08310"
     CDS             6508..9483
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400478.1"
                     /locus_tag="MK857_RS08345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08310"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_000400477.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.8e-92, bitscore:
                     298.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.1e-08,
                     bitscore: 25.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.4e-22, bitscore:
                     70.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHKYTTNNFLVRNAIIGIHELLECDYNSFLETIRENKIFQEQLF
                     VASRSLYESLQKYYSGDSMKRKKINQLSESVYKYYKRSKERSTPFGLFSETSIGSFSST
                     EKLNLNGKTLKKVLLDSEWLIRLVFKIEKEYSRELAYKINPANYQFGDRVVQLFSINDT
                     KIEEVNIKFTKVYQLIDELCCDKYVYFNCIIEKLVESYGEEYRDIATSYIMSLIDSHFL
                     ISNINSELIMNFKFEEFISKVKEIDKQNLYYFKLIAISNLIVEYSELEIGDGIEKLKEI
                     YKLMSSLVETPNFLQIDLYNDGQIQLGNENKTQIVEFAEFLVSNSDHVKRTYLDDYKEK
                     FLDKYGVNREVQLMELFDSNLGIGSPYGYQHPKNDFWESSPSTVYFSEKEELEYLNNFE
                     KALETGGNIQLYNEEDFFNQDKDKINLGFELFFYVNKVDGKSVLSLTNTGCSKNLGASS
                     GRFSILSDKLEHYHQTITQIVENNNHVSGYNSCEITFLPENLRHANVMRTTNVREKVLS
                     LFTNMDKRSQILSDIYIGIDSKNSFYARNFKTKELLKFYSTNMYNQMMFSNELRFLCEI
                     AQEDHFGIFPWEMVYQKFSHIPRIVFKDIIVAPERWRLSGRMLSKDIHQIILENNLPTK
                     LYVDNSDNRILINRNNPLDNQLFEDIVRKSSNKNEELCLSECIFDSHLVEKESTTHISD
                     IVVPVFAKDEIKEPRYIKEILPEVIPTNVRQKIPFDEWLYFKLYMSADRQEEFLSDIMP
                     QILKLVNLDDGMSFYIRYTDPKFHIRLRIRTQNLYKSFEKIQEIFQLCIQNKLISNIDI
                     STYDREIERYGGLERIPLVEEIFCLDTEIVINSLSLIRQKRLDLTLDDLAIIFNYFYLK
                     SFFKDNNKEIIQFLEFACPEHLDSQNRDKNRNTALIDLYLIKGYLINLLPELSKLCQRL
                     KKLSDSCIQLSDDYTYIIYDSIIHVHNNRLFGIKRENETKIYAIIRGLIISEEFRNGHN
                     HG"
     aSDomain        6940..7185
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MK857_RS08345_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.30E-08"
                     /identifier="RREFam001.1"
                     /label="MK857_RS08345"
                     /locus_tag="MK857_RS08345"
                     /protein_end="226"
                     /protein_start="144"
                     /score="25.6"
                     /tool="antismash"
                     /translation="PANYQFGDRVVQLFSINDTKIEEVNIKFTKVYQLIDELCCDKYVY
                     FNCIIEKLVESYGEEYRDIATSYIMSLIDSHFLISNI"
     gene            9476..11272
                     /locus_tag="MK857_RS08350"
                     /old_locus_tag="MK857_08315"
     CDS             9476..11272
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943315.1"
                     /locus_tag="MK857_RS08350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08315"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_031912841.1"
                     /transl_table=11
                     /translation="MDKFTLKNFFQTILTIPKTIRLIFRIERKYASYLIILNILQSIIP
                     LASLFIYQELINAVLKKGSNIFSVLIVYILMQMMLSILSQLNSYISEKFNMNLSYNLNL
                     KLLKKTSSLNLIDFEQADTYNLIENIVQDSTYKPFQLFNAIIGVITGFLSLLTSIIYVS
                     TWNVAVSTFLLIIPVISLVIFMRVGQLEFLIQWERANSEREVWYINYLLTHDFSFKEIK
                     LNGISQYFIDKYGTLKRNFMNQDLNISKKKVLFRGSLDILLNFINGIAIFMMIQSIRSG
                     KLLVGNFVSLIQAITRVNTYSQSMIQNTYIIYNTSLFMEQLFKFFDMEVSNISIQNSRI
                     SRIEKRIDKIKVNNLSFIYPGSVKKTLEDINVEFNKGELVAIVGKNGSGKSTLVKLLSG
                     LYQPSEGQIYYNNESSDVLDLSYYQNNVSVLFQDFVKFELSVRENIGLSDVNSISDSKI
                     KKHIDNLKLNFLTAENNFNLNQRLGTWFNDSRQISGGQWQKVALARTFFKNASIYILDE
                     PSSALDPVSEKEIFDEFVTRSRDKIALFVSHNLMAASRADRIIVMQDGRIIDEGKHDDL
                     ISKSKYYRELYYSEKYEEESDG"
     gene            11265..12542
                     /locus_tag="MK857_RS08355"
                     /old_locus_tag="MK857_08320"
     CDS             11265..12542
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344171.1"
                     /locus_tag="MK857_RS08355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08320"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_000344171.1"
                     /sec_met_domain="LANC_like (E-value: 3.1e-59, bitscore:
                     191.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDENKVIIDLSEKVFAKFDEQLKRYAEQPNYDLLTLSSGLPGLIL
                     LSSELTSLTSERKYSARTGKYVNFMVKQMRNYGVLSDSLFSGVSGIGISILHLVEEHPE
                     YHNLLISFNEYIKYYTLSKIENIDIKKISPTDYDIIEGVSGVLVYLLSQEQDENDYIIN
                     RIINFLSEFSLKNSTLTGFYVESKNQMSKTESKLYPLGCLNFGLAHGLAGVGAMLSYSK
                     LKGYSNEKSIAAIKKIIMLYEKHELKNYMWKEGLSDIELKKTEKSNLQYEFIRDAWCYG
                     SPGISLLYLYSSLALEDKKLKSKACNILKASIRRSNGLEQSILCHGFSGAIEICLFFKK
                     IYKTTDFDDCIKSLKEKLISDFREDMTYGFNTTAEFENIKTKDNLGYLDGIIGILLTMI
                     ELNNLKVTTNWQRALLLFDDVIKEVK"
     gene            12544..13260
                     /locus_tag="MK857_RS08360"
                     /old_locus_tag="MK857_08325"
     CDS             12544..13260
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226539.1"
                     /locus_tag="MK857_RS08360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08325"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_001226539.1"
                     /transl_table=11
                     /translation="MRKILFSLVVLIGICTLVACRLVDNKTIEFHDQSFNQFTYKGNDY
                     TIMNQIVDENDLGTVKESFFKTLVIDRNSQKVVTKSNSDTVSLAYSGLYNFSDGLAISI
                     NDSYYKVSLSSDVQSNNEMLSLEEFNNNSAGGELAIDPSDCRIVKFNNKKFRISSDIVS
                     DDKLKEFLGVIADSKTFILNTGQEISKSELNKIDYSGSNSNEKREVWDYGEVYLLAEEG
                     TIAVEINNEFRIARIE"
     gene            13528..13932
                     /locus_tag="MK857_RS08365"
                     /old_locus_tag="MK857_08330"
     CDS             13528..13932
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368528.1"
                     /locus_tag="MK857_RS08365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08330"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_000878635.1"
                     /transl_table=11
                     /translation="MKYYIHVRGSKIPVTETVYKSYWQLVNHEKYLNRKDRKFGVLPFS
                     SFEVDGLLLANVLPDTTVDVERFIENKLLIEQLNEALLTLSDKEFKIIDALYFREHTIR
                     EVAIEHEMSATSLFRMRNTILDNLRKFFEK"
     misc_feature    14109..14119
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            14294..14383
                     /locus_tag="MK857_RS11595"
     CDS             14294..14383
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042617.2"
                     /locus_tag="MK857_RS11595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_306341207.1"
                     /transl_table=11
                     /translation="MLNFLYSRNMLTKKEYEKIKNRLRIKYTN"
     gene            14437..16192
                     /locus_tag="MK857_RS08370"
                     /old_locus_tag="MK857_08335"
                     /pseudo=""
     CDS             14437..16192
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864824.1"
                     /locus_tag="MK857_RS08370"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08335"
                     /product="recombinase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKKNNVEIIKADSLVRRRGDNFERESKRVAAYCRVSSDSEDQKNS
                     YESQVRHYKDYISQRSDWELAGIYADEGISGTQVGKRQDFQRLINDCVNGEIDYIVTKA
                     IARFARNTLDTLKYVRMLKDMQIGVYFEEENIDTLTMDGELLLTILSSVAQQEVENTSA
                     HVKKGLKMKMQRGELIGFQGCLGYDYDVETKQLSINKKEAKIVRYIFERYLEGIGGKVI
                     ARELDELGYKSPRGLDHWNDTTVLGIIKNEKYKGDILMGKTFTVDPISKRRLSNFGEED
                     KYYIKDNHEPIISKEDFEKAQEIRLRRAGNKKTAANVNGKRERYSKMYAFSSMLECGFC
                     GSILSRRSWHCRSDYRKVVWHCVTSIKKGKKFCKHSKGLEELAIEGAFMEAYRKLYHSN
                     ENLMTDLLETIESELNDNSLNKELKKDYKQTSNITKKRGKSCKSKARREN"
     misc_feature    16297..16312
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.03"
                     /tool="antismash"
     gene            16866..17384
                     /locus_tag="MK857_RS08375"
                     /old_locus_tag="MK857_08340"
     CDS             16866..17384
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013852041.1"
                     /locus_tag="MK857_RS08375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08340"
                     /product="ClbS/DfsB family four-helix bundle protein"
                     /protein_id="WP_003065519.1"
                     /transl_table=11
                     /translation="MRTYENKEELKKEISKAFEKYILEFDNIPESLKDKRITEVDRTPA
                     ENLSYQVGWTSLVLKWEEDERKGHQVKTPSDEFKWNQLGELYQWFTDTYAHLSLQELKA
                     KLNENINSIYAMIDSLSEEELFEPHMRKWADEATKTATWEVYKFIHVNTVAPFGTFRTK
                     IRKWKKIVL"
     gene            18032..18259
                     /locus_tag="MK857_RS08380"
                     /old_locus_tag="MK857_08345"
     CDS             18032..18259
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MK857_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MK857_08345"
                     /product="hypothetical protein"
                     /protein_id="WP_003065516.1"
                     /transl_table=11
                     /translation="MNNTISIEVLAGSILELTFYKKFEFEIVNIKTGRMPGNEEFSVSV
                     NDLRSRVSKSEHIFVFICYNHHRAVNKKRE"
     gene            18261..19088
                     /locus_tag="MK857_RS08385"
                     /old_locus_tag="MK857_08350"
     CDS             18261..19088
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013852040.1"
                     /locus_tag="MK857_RS08385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08350"
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="WP_003065514.1"
                     /transl_table=11
                     /translation="MLVDKLQEQSDLTPQEQVVASFILENMKMIPSFSAQGLAGKSFTS
                     KATVVRLCQKLGFSGFQEFKLQLLAEWHEKQRLDALLSEEPISSHTNFEDLLDILPQIY
                     DKALTNTRFTLRKQQLPKLINFIEKSDQIIFLGTGISYISAQAAAFKFSNLGLQATAME
                     SLNKHFLALNKDKKTVFFLISFTGKNESILQMARYLKQEGFCPIVGLVGPYYEQLKPYC
                     HEIIELPNRESLIGLDVVSSNISLTYIIDLLFSMYLAKTYDKQVKVNLSNRPK"
     gene            19231..21111
                     /locus_tag="MK857_RS08390"
                     /old_locus_tag="MK857_08355"
     CDS             19231..21111
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0015573 - beta-glucoside transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0015759 - beta-glucoside transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003065512.1"
                     /locus_tag="MK857_RS08390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08355"
                     /product="beta-glucoside-specific PTS transporter subunit
                     IIABC"
                     /protein_id="WP_003065512.1"
                     /transl_table=11
                     /translation="MKKYQALAQDIVEHIGGKDNVTGLVHCITRLRFNLVDESKADDDY
                     LKALDGVVTVMKSGGQYQVVIGNHVADVYEEVLPLLNITDSKVSGQPVNVKLFDRMIDT
                     ISGIFQPVLGIMAACGMVKGFNTLFVTLGLYENTSGVYQILNAVGDAMFTFMPLFLGYT
                     AAKKFKLKPMLGLAIGAALCYPAIQASSLSANSEALFTLFEGSVLASPVYINFLGIPVI
                     AIDYTGTVIPVILAVWFASKCEWVYNRLIPDLVKFFFVPMLTMLTVIPVTLLVLGPLAT
                     FGSTLISQFTLAVRDISPLLAGALVGATWQILIIFGLHWGFIPVYINNVMTLGYDNVMM
                     PFFACTFATSAVVLGIYCKTKNQKLKEMAIPNFISGIFGITEPAIYGMLLPLKKPFIIS
                     CIAGGIGGAFYGHFNFRKFIMGGMGIFELPNMMNPDGSMGNIIVAFVGILISMVVGLIL
                     TLMFYKEDELVQNESEEKDTILLSPLEGEVVPLESIEDQTFASGMLGKGLAIIPSQGTL
                     KSPVDGEIIALFPTGHAIGLKSDSGIEILIHIGMDTVQLNGRGFSTKVTAGEHVQKGQV
                     LIEFDQKLIQSEGYSLVTPVLVTNWEEFSDMTIENQQDIAFGQKMISVRK"
     gene            21117..22517
                     /locus_tag="MK857_RS08395"
                     /old_locus_tag="MK857_08360"
     CDS             21117..22517
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013852038.1"
                     /locus_tag="MK857_RS08395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MK857_08360"
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="WP_003065510.1"
                     /transl_table=11
                     /translation="MDNEFLWGVATAANQCEGGIEQRGKALVDVIPFGEQRFGVMKGEI
                     CHNTLQNDTYFPGRQAINMAENYDTDIDLLIELGINAYRLSFSWSRIFPKGNEDKPNPS
                     GLAFYDKIINKLLDNSIEPIVTICHFDLPLYLVEEFGGWGDRQVVDYYLNYCEVLFQHF
                     KGRIKYWITFNEINMILHLPFLAAGLYVSDKSYPLEYIYQAAHHQLIASAKATKLSHEI
                     SKENNIGCMLAAGKVYSYSANPEDVWLALEKDRENYFFTDVQVRGEYPTYAQKFFKRND
                     INLLIPEEDLLLLKEYTVDYISLSYYNSRCVSADASLATNSGNLFASVSNPFLETSQWG
                     WPIDPLGFRITLNELYDRYQKPLFVVENGLGAIDSLDEHNEIDDTYRINYLSDHITALL
                     KAKDEDGIPILGYTMWSGIDIISATGGQMSKRYGLIYVDMDDQGQGTLKRIPKASYRWY
                     REMIRENR"
ORIGIN
        1 agctacccgc taatataaat ataagatgat attatgaaaa agataggctt attgtcgaat
       61 gtttttatat cattgtttat tgttatatta gctagcggtt ctgtgtcatc aggagtaagt
      121 gctaatgaaa ataaggaaat tagttataat gttttagtta gtgaaaataa atctattgag
      181 gatgtagaag atgttttaca aagtcaagga attaaagtta ctgataaaat acctgaaata
      241 aattttttaa ctatttctac cgaaaaaagt gaagatacaa taaaaaaaga aaactctaat
      301 tatattgatg acatagttat agataatact atgactgtaa agcctaatat tacttatttg
      361 tatggggaca aggtttatac aaatactaat ttagattttt ggggaaatca gtgggatatg
      421 caaaagagta ttagtactgg aagtaaattt caacataagt cttctggtaa agcaacaatt
      481 ggtgtaatag attctggtat tacatatgat aatccagata tttattcaca cattatttca
      541 gtacaaaatt tcacatcaga tttggaaaca ggaatagttg ataaccaaaa tgttgtagat
      601 aaaattggcc atgggacctc tgttgtggga caaatttcat caagtggaga atatttaggg
      661 atagcacctg acatgaaaat acgaatgtat cgtgtttttg atgaagggaa tgctcaagac
      721 caatggattc tcaaagcgct cattcaagca gcaaaagatg atgttgatgt tattaacctt
      781 agtttaggag aatatttgtt aagagattcc actgatgaag atgatgatac agctttgatc
      841 aatatctatc aacgggcaat taattatgct cataatcaag gttccgttgt cgttgcttca
      901 gtaggtgatg aagggatgga tttacagaat caagatgaat taaaaaacta tcttggtagt
      961 ttaagaggaa aagattatag tcaagttgat ggaactgtac aagatattcc ggctgaatta
     1021 gacaatgttg ttacagttgg ttcagtagat gataatgatc ttgtatctag tttctcaaat
     1081 caagggaatg gcgacattga tatctatgca acaggaggtg gaagtcaagc gctttctaaa
     1141 gtaggatatg ataaatgggt agctgataaa ttatatgaaa aagaatggat tcttgttcca
     1201 acgcttgaag gaaagtatac atatgcatat gggacttcaa tttcgactcc taaagtctct
     1261 gcagctttag gattgattat agaaaagtat aatttgaagg accaaccaga tgaagctatt
     1321 cgaattttat atgataattg ttttcttagt aataatggaa acaatggaca aattaggcta
     1381 ctaaatatta caaattttgt gcaataatag tgtaaaatag tagtatgaga taaaagaggt
     1441 acctagtatg tataagattt tggtagttga tgatgatttt gaaattgtaa aattgatgcg
     1501 aacaatttta gaaatgaaaa actataatgt gacgacttat caagaagtta ggcttcctat
     1561 aaaaataagt gattttgatg gatttgattt aatattgctt gatgttatga tgccaaatgt
     1621 tgatggtctg caaatctgta aacagattcg taaatcagta tcctctccga ttatttttgt
     1681 cagtgcaaaa gattctgaag atgatattgt atctggctta aatctcggtg gtgacgatta
     1741 tatcacaaag ccatttagtg ttaatcaact agttgctaag gttgcagcgc atttaaaacg
     1801 agaagaacgt tatagaaatg ctgaatctaa tgaatctgtt attcgagaat tatttccact
     1861 aacattttac cttcaagaaa aactcgtgtg tgttaatggt gaagctattt ctcttactaa
     1921 aagggaatat gatattttag agctattatc tagtaagaca aataaggttt atacaagaga
     1981 agaaatctat gaatgtgtct atggtgatga agcagatgca ttatttcgtt caatttcgga
     2041 atacatttat caaattagag tcaagtttgg tccctatgga attaatccca ttaaaacaat
     2101 aagggggatg ggatataagt ggaatgatga aaaggtattc aattaataag cggattttaa
     2161 ggacagttct tgaaatagtg attggtacag ttgcaaatgt tattatgttg cttgtattga
     2221 gctacgttct tatttttaca ggtcagttga acacatatgg aacagactat catatttcaa
     2281 ttagtgatag taaatctgct aacggtatta agaatcaaat ggattattct gtctttgatt
     2341 atgtattgtt tgatagcgat aatggcgaat tggtctctgg aaattatcaa aaacaggatt
     2401 tacaacatta taaagaagtt tttgatactg gaagttcggt tagcgagggt tctatattgt
     2461 ttacaaaata tgaaaactca gattttattt tggttattag aagaccaaca atgcccgaat
     2521 ttgtaaatcg aaactttcga catatttcct ataatttagt ctcttatttg ttttttatag
     2581 tgctagaatt attactcatc tctatctctg ttattaggct cttaagagaa tttacaaaaa
     2641 attttcgtct aattgaaaaa atatctctga atatgggaat accaggaatg gatattggac
     2701 gtaaagaaac tgcaatctta gaatgtaata acattttatt gacgctttat caaaaagacg
     2761 aagagttgac aaagttatta gaaatggaga aaaaagataa agaagatttg tcatttcaag
     2821 ttgctgcatt agcacatgat attaaaacac cattaactgt tttaaagggg aatatcgagt
     2881 tgcttgagat gactaatcta gatgaaaaac aattagattt tatgtcctca atgaatcata
     2941 gtgttggtat atttgaaaag tattttaatt caatggttaa ttactcaaga ttgctaattg
     3001 aggataagaa ttatcaggaa gatattgaat tatcaaaatt tcttgatgaa ttatcattag
     3061 aatgtcgaga tattatgtct tcaaaaaaaa ttaattttca aatagttaat gaatcccata
     3121 ccagagtgat taaaggaaat cgtctcaact tagatcgagc tttgataaat atcttatcta
     3181 atgcgactag attttgttca gaagagggca aggtggtact gactatatct gaaagttcca
     3241 actttatcag ttttgagatt tggaataatg gtttaccatt tacagaagag tctcttaaag
     3301 atggaggaaa acttttttac acagagaata aaggaagaaa tgataagcat tacggaatag
     3361 gactttcatt tgctcaaaag atagctatga gacatcaagg tcaattaata ctctcaaatc
     3421 cacaaaatgg tggtgcacag gtcactttat taattaaaaa attttagggg ctggtcaaaa
     3481 agcctaatat aaacaaaacc gcatgaaatc tttcatttaa aaacgttgat tttatgcgat
     3541 tttttatttc gaaaatttga aaaaatcaaa gagatatcga ctttttgctc aatttttttc
     3601 tgaacaaata ctgaaatttc ttttgtatta taataaaaga aatggaggca gaaaaaatgg
     3661 aagttatcat tcaaaatcta agaaaaagct ataaagacaa agaggtttta aaagacgttt
     3721 catttaaaat tgaagaaggt actatttgtg gtcttctggg agtaaatggg gctgggaaat
     3781 ccaccattat gaaaattctt tttgggttag aaagagctga tagtggagaa gtcattttca
     3841 atggaaagca taaggatatt gtagaagaaa atagatttga tattggagcg ttgatagaat
     3901 ctcctgctat ctatttgaat ctttctgcat ttgacaattt aaaaacacga gcattgctac
     3961 atgatattcc agatgaaaga atttatgagg tacttcagtt ggttggttta tctgatactg
     4021 gaaaaaagaa ggcagggcac ttttcattag gaatgaagca acgacttggt ttaggaatgg
     4081 caattattac caatcctgat ttattaattt tagatgagcc aactaatggt ctagatccag
     4141 atgggataaa agaattgcta aatttaatta gggatctaaa aaaatctgga atgacagtcc
     4201 tcttgtccag ccatcaacta agtgaagtca gcaaaattgc ggatcaaatc gttatactga
     4261 atcagggcaa gattttttac gatgatatta ataagaattc aaatgattta gaaaaactat
     4321 tctttagaat tgtccatgga ggtgatggaa atgactaata tttttaaatc tgagtggctg
     4381 aagcaaaaat ctagttctga taaaaaatta ctaatcctta ttcctttgct agcaattttt
     4441 atagctttca tactagcagg acctctcaat ttagaaagtt tttcaattta ttggtgggag
     4501 ggaggattcc ttttcactct ccttgggtta ttgtttttag ctgattatag cgcggaggag
     4561 aatgcaggtg cgtttcaaaa tattagcttg ggtagatata cgtttactat ttatttagcg
     4621 aagatactgt tgaagttcaa ggatgttttg atttcaacct ttatttttac gataatattt
     4681 tatggcatct catttctttt ttcaggtgtg atatcagtag acattggtaa agatttgatt
     4741 tgtttattac ttattggtgt ttcttctgct tgggtattac cactattata ttttctagca
     4801 aagtggataa atccctactt gttgttggct acaaattctc ttatttgctt attagttgct
     4861 cctctaatag ctcagacatc ggtttggttc atatttcctt atacttatca ctataaaatt
     4921 gcttatgctc ttttacattt aaaaccctca ggtgatttag aggcagcatt aagtggagtt
     4981 gaaatatcga caattttaat atcagtatct ctttcaatct tagtttttgt gagtttcctt
     5041 agtttgttga agtggaggat aactaatgaa caaaattcta aaaagtgagt tgctaaagtt
     5101 gaaaggctct cttactttaa atcttatttt aattttatca attattcaat tattcacaat
     5161 tcctctttat ttacagttta caaataattc agttgtaatt gaaaatatca tttttttacc
     5221 tatgttagga tattgtatat tagcatcaat tttctctatt tttcttcatg aacaagagga
     5281 aaaagcaaat ttctttcaaa atattaaaag cgaaaaaaat agtggaatta tttggggaat
     5341 aaagcttatt tcgacagact tacttatggt tttattggga gttccagttt ggatagtggt
     5401 aggagttgaa tttaatagac tctcttactt tgcgtatgtt ggtgtgatta cttggttatt
     5461 attagtctta cttaaccatt tccatatgtt acttagtctt atcatgggaa agggagggaa
     5521 tctagtaatt tcttttatcg aatgtctgtt tattatattt gcaaccaata aagtattttt
     5581 aaataacttc tggttgccta tcgttttacc tgttaatatg atcctagaaa ttgggaaaaa
     5641 tgaaattttt atgattctag tatacttaat tggttttatc atattatcgt atttttgtaa
     5701 tttagctgtt atgaataatg ttgaaattca aaaaatatgt aaaaagaggt aaattggtta
     5761 gaggtcacta aaagagtaga atacaacaaa attcaataga taaaaagcga atgacagcat
     5821 attttgaaat ctaaagattg cagatcatcc gctttttatg tctattttat tatcttttca
     5881 agacagtatt gttcatgata ttttaaaaat atcagacttt ttcagcagtt tcattggtca
     5941 actatctttt tatttaattg tccagagtat cagtataaat atttcatgca ttctaaataa
     6001 aaaatttgtt cattctctat aattatgaac aaattctgaa ctaggtatct tacaatatat
     6061 ttgttcgaac aaagaaaaaa taattggagg aattttatta tgaacaatga agattttaat
     6121 ttggatcttg tcacaatctc aaaggaaaac aactcaggag cttcacctcg ggtaactagt
     6181 aaatcattat gtactcctgg atgtaagacg ggtattttga tgacctgtgc aatcaaaact
     6241 gcaacttgtg gttgccattt tggataaaat ttatttgttt agtaactatc tttttgcaaa
     6301 tcttgactaa gaaagaaagg gactctatat cttttcgagt aaggtccctc taaatattag
     6361 aatatttgtt taggatatta ctctttagac gaatatgtct attgctaaaa taaaggtagt
     6421 ggatagtagt ctactacctt tatttttata aatttccaaa ataatatttg aagatttata
     6481 aaaataattt agaagttgga gctgctaatg gaacataaat atactacaaa taattttttg
     6541 gttcgtaatg caatcattgg aatacatgaa ttgttggaat gtgattataa ttcattttta
     6601 gaaactataa gagagaataa gatattccag gagcaactat ttgtagccag caggagttta
     6661 tatgaatcgc ttcaaaaata ttatagtggt gattcaatga aaaggaaaaa aatcaaccaa
     6721 ttatcagaat ctgtatataa atattataag cgtagtaagg agcgctcaac accatttggt
     6781 ttatttagtg aaacttcaat aggttcattt tcttctacag agaaattaaa cttgaatgga
     6841 aaaacattaa aaaaagtact cttggattca gagtggttaa tacgtctagt ttttaagatt
     6901 gagaaggaat attctcgaga attagcctat aaaataaatc cagccaacta tcaatttgga
     6961 gatagagttg ttcaattgtt ttctataaat gatactaaaa ttgaagaagt caacataaag
     7021 ttcactaaag tttatcaact tattgatgag ctttgttgtg ataaatatgt atattttaac
     7081 tgtattatag aaaaacttgt tgaatcctat ggtgaagagt atcgagatat tgcaacatca
     7141 tatatcatga gtttgattga tagtcatttt ctaatttcaa atattaattc agaattaata
     7201 atgaatttta agtttgaaga attcatttct aaagtcaaag aaatcgataa gcaaaatctt
     7261 tattatttta aactaatagc aattagcaac ttaattgttg aatattctga attggaaatt
     7321 ggggatggga ttgaaaagct taaagaaatc tacaagttaa tgtcatcgtt agttgaaacc
     7381 cctaattttc ttcaaattga tctttataat gatggtcaaa tccaattagg taatgaaaat
     7441 aaaactcaga tagtagaatt tgctgagttt ctagtaagta attcagatca tgtaaagcgt
     7501 acttatttag atgattataa agaaaaattt ttagataagt acggagtaaa tagagaagtt
     7561 cagttgatgg agttgtttga ttctaattta ggaattggtt ctccatatgg atatcagcac
     7621 cccaaaaatg atttctggga atcttcgcct tctactgtat attttagtga aaaagaagaa
     7681 ttagaatatc tcaataattt tgaaaaagcc ttagaaacag gtggaaatat tcaactttat
     7741 aatgaagaag atttttttaa tcaagacaaa gataaaatca atctaggatt tgagttgttc
     7801 ttttatgtta ataaagtaga tggtaaaagc gtactaagct taactaatac aggatgttct
     7861 aagaatttag gagctagctc aggcaggttt tctattctat cagataaatt ggaacattat
     7921 catcaaacta tcactcaaat tgttgaaaac aataatcacg tatcagggta taactcttgt
     7981 gaaataacat ttttaccaga gaatcttcgt catgctaatg ttatgcgcac aacaaatgtc
     8041 agagaaaaag tattatcact ttttacgaat atggataaga gaagtcaaat tttatctgat
     8101 atatatattg gtattgattc taagaatagt ttttatgcta gaaattttaa aactaaggaa
     8161 ctcttaaaat tttatagtac aaatatgtat aaccaaatga tgtttagcaa tgaattacgg
     8221 tttttatgtg agatagctca agaagatcat ttcggaatat tcccttggga gatggtttat
     8281 caaaaatttt ctcatattcc tagaatagta tttaaggaca ttattgttgc tcctgaacgt
     8341 tggaggctta gtggaaggat gttgtcgaag gatattcatc agattattct tgaaaacaat
     8401 cttccgacaa aattgtatgt tgataacagt gataatcgaa tattaattaa ccgtaataat
     8461 ccactagata atcaactttt tgaagatatt gtaagaaaaa gtagtaataa aaatgaagaa
     8521 ttatgtctat cagagtgtat ttttgattca caccttgtag agaaggaatc tacaactcat
     8581 atttctgata tagttgttcc agtatttgct aaggatgaaa ttaaggaacc taggtacata
     8641 aaagaaatat taccagaggt tattccgaca aatgttagac agaaaatacc atttgatgaa
     8701 tggctctact ttaaattgta tatgtcggca gataggcaag aggaatttct ttcggatata
     8761 atgcctcaaa ttttgaagtt agtaaattta gatgatggga tgagcttcta tatcagatat
     8821 actgatccaa aatttcatat ccgactaagg ataagaacgc agaatttata taaaagtttt
     8881 gaaaaaattc aagagatttt tcaactctgc atacaaaaca agttaatatc aaatatagat
     8941 atttcaacgt atgacagaga aatcgaaagg tatgggggac tagaaagaat tcctttggta
     9001 gaagaaattt tttgtctaga tactgaaata gtcatcaatt cattaagttt aattcggcag
     9061 aaaagattag atttaaccct agatgattta gcaataatat ttaactactt ttatctcaaa
     9121 tcatttttta aagataacaa taaagaaata atacaatttt tagaatttgc ttgtccagag
     9181 catttagaca gccaaaatag agataaaaat aggaatactg cattaattga tttgtactta
     9241 ataaagggat atttaataaa tcttcttcca gaactatcta aactatgtca aagacttaag
     9301 aaattatcag acagttgtat tcaattatca gatgactata catatatcat ttatgatagt
     9361 atcattcatg tacacaataa tcgcttattt ggtataaaga gagaaaatga gactaagatt
     9421 tatgctataa ttcgcggatt gataatcagt gaagaattta gaaatgggca caatcatgga
     9481 taaatttaca ctaaaaaatt tttttcaaac aattttgaca attcctaaaa caataagatt
     9541 aatttttcga atagaaagaa aatatgctag ctatctaata attttaaaca tattacaatc
     9601 aataattcct ttagcaagct tatttatcta tcaagaatta atcaatgctg ttttaaaaaa
     9661 aggaagtaac attttttcag tattaattgt ctatatatta atgcaaatga tgctatcaat
     9721 actaagtcag ttaaactcat atataagtga gaaatttaat atgaacttgt cctataatct
     9781 caatttgaag ttattgaaaa aaacatcatc tctaaattta atagattttg aacaagcaga
     9841 tacatacaat ctcattgaaa atattgtaca agatagtaca tataagccgt tccaactttt
     9901 caatgctatc attggtgtga ttacagggtt tctatcttta ttaacaagta ttatttatgt
     9961 gtccacttgg aatgtggcag tatcgacttt tttactgata attcctgtta tttccttagt
    10021 aatttttatg cgtgttggcc agctagaatt tttgattcaa tgggagcgag caaattcgga
    10081 gagggaagtt tggtacatca attatcttct tactcatgat ttttcattta aagagattaa
    10141 actaaatggt attagtcaat atttcattga taaatatgga acattgaaaa gaaattttat
    10201 gaatcaggat ttgaatattt cgaaaaagaa agttcttttc agaggaagtt tggatatttt
    10261 attgaatttt attaatggta tagctatttt tatgatgata cagtcaattc gaagcggtaa
    10321 acttttagta ggtaattttg taagccttat tcaagcaata actcgtgtaa atacctactc
    10381 acaatctatg atccaaaata cttatatcat ctataacaca agtttattca tggaacaatt
    10441 atttaaattt tttgatatgg aagtaagtaa tatttcaatt cagaatagta gaatctcaag
    10501 aattgaaaag cgcattgaca aaataaaagt caataatctc tcttttatct atccaggaag
    10561 tgtcaaaaaa actttagagg atattaatgt tgagtttaat aagggtgaac ttgtagcaat
    10621 tgtggggaag aatggttctg gtaagagtac cttagtaaaa ttactatcgg gattatacca
    10681 accttcagag ggtcaaatat attataataa cgaatctagt gatgtcctag acttgagtta
    10741 ttatcaaaat aatgtttctg ttctttttca ggactttgtg aagtttgaat tatctgtgag
    10801 agaaaatatt ggcctaagtg atgtaaacag tatatctgac tccaaaataa agaaacatat
    10861 tgataactta aaattaaatt tcttaaccgc agaaaacaat ttcaacctta atcaacgttt
    10921 agggacctgg tttaacgata gtagacaaat ttcaggagga caatggcaaa aagtagcatt
    10981 ggctaggact ttcttcaaga atgcaagcat atacattttg gatgaaccaa gttcagcgct
    11041 tgatcctgtt tcagagaaag aaatatttga tgaatttgta actcgttcta gagataagat
    11101 tgctttgttt gtgtcacata atctaatggc tgcgagtaga gcagatcgaa ttatagttat
    11161 gcaagatgga cgaattattg atgaaggaaa acatgacgac cttataagta aatctaaata
    11221 ttatagggaa ctttactatt cagaaaagta cgaggaggag tctgatggat gaaaataaag
    11281 ttattattga tttatctgag aaagtatttg ctaaatttga tgagcagtta aaaagatatg
    11341 ctgaacaacc gaattatgat ttattgacct tgtcttctgg tttacctgga ttgatattat
    11401 tatcttcaga attgacaagt ttaactagtg aaagaaaata ctccgctaga acgggtaaat
    11461 atgttaactt tatggttaaa caaatgagaa attatggtgt tttatcggat tctttatttt
    11521 caggagtttc tggaattgga ataagtatac ttcatttagt tgaagaacac ccagaatatc
    11581 ataacttatt gattagtttt aatgagtaca ttaagtacta tacgttaagt aagattgaaa
    11641 atatagatat taagaaaatc tctcctacag attatgacat catagaagga gtatctggag
    11701 tattagttta tcttttatct caggagcaag atgaaaatga ttatataata aacagaatta
    11761 tcaatttctt atctgagttt tcactaaaaa attctacttt aacaggcttc tatgtggaat
    11821 caaagaatca aatgtccaag acagagtcta agctttatcc gttaggatgt ctaaattttg
    11881 gtttagcaca cggccttgcg ggtgttggcg caatgttgtc ttattcaaaa ttaaaaggct
    11941 attctaatga aaaatctatt gcagcaatca aaaaaattat aatgttatac gaaaaacacg
    12001 agttaaaaaa ttatatgtgg aaagagggat taagcgatat tgaactaaag aaaacagaaa
    12061 aaagcaattt acagtatgaa tttattcgag atgcgtggtg ctacggtagc ccaggaatta
    12121 gtttactata tctgtattca agtttggctc tagaagataa gaaactaaaa tctaaagctt
    12181 gtaacatctt gaaagcatcc atcaggagaa gtaatggttt ggaacaatct attttatgtc
    12241 acggattttc tggagcaatt gagatttgcc tattttttaa aaaaatttat aaaacaactg
    12301 attttgatga ctgtataaaa tctcttaagg aaaagttaat tagtgatttt agagaagaca
    12361 tgacatatgg ttttaatact accgcggaat ttgaaaatat aaaaacaaaa gataatcttg
    12421 gttatttaga tggaataatt ggaattctgt taacaatgat cgaactaaat aacttaaagg
    12481 ttacaacaaa ttggcaaagg gcactcttat tatttgatga tgttataaag gaggtgaagt
    12541 agcatgagga aaattttatt tagcttagtt gttcttattg gaatttgtac tttagttgca
    12601 tgtagattgg tagacaataa aacaatagag tttcatgatc aatcatttaa tcaatttaca
    12661 tataaaggaa atgattatac aatcatgaat caaattgttg atgaaaatga tctaggtact
    12721 gtgaaggaat ctttttttaa aacattagta attgatagaa atagccagaa agttgttact
    12781 aaaagtaata gtgatacagt atcattagca tatagtgggc tctataattt tagtgatggt
    12841 ttagctattt ctataaatga ttcttattat aaggtttctt tgagttcgga tgtgcaatcc
    12901 aataatgaaa tgctgagctt ggaagagttc aataataatt cagcaggtgg ggaacttgca
    12961 attgatccat ctgattgtag gatagttaaa tttaataata aaaaatttcg tatttcatct
    13021 gatattgtat ctgatgataa actaaaagaa tttctaggag taatagcaga ttcaaaaaca
    13081 tttattttga atacgggaca agaaatttct aaatcggaac taaataaaat agattattct
    13141 ggttctaatt ctaatgaaaa aagagaagtt tgggattacg gagaagttta tttgttagca
    13201 gaagaaggaa ccatagctgt tgagattaat aatgaattta gaatagcgcg catagaataa
    13261 attatagatt atctaggtat tacattgctt atatagcaaa atatcttatt gttacctact
    13321 aaacagaaac ttattaaaat atagatcagc aagttcagaa gagcttgctg ttttttggta
    13381 catataattt tttttggaac aagagcacca tattttcact cttatagtga ggagaactcc
    13441 ttgatttgat aaaagtgaga aatagctatg gttgagataa ggagccctcc ttttatgact
    13501 aagaaaaaat cataaacgga ggctgaaatg aaatattata ttcacgttag aggtagtaaa
    13561 atccccgtaa cagaaacggt ttataaaagc tactggcaat tggtcaatca cgagaagtat
    13621 ctgaatagaa aagataggaa atttggagta ttaccttttt catcatttga agtagatggg
    13681 ttactgctag caaatgtact gcctgataca actgttgatg ttgaacgttt tatagaaaac
    13741 aagctcctta ttgagcaact aaatgaggct ttattaacct tatctgataa agagtttaaa
    13801 atcattgatg ctctgtattt tagagagcat accatcagag aagtagcaat agagcatgag
    13861 atgtctgcga ctagtctatt tcggatgaga aatacaattt tggacaacct acgaaaattt
    13921 tttgaaaaat aaggaaacag gagactaaaa aattcactct ttatagtgag aggaattttt
    13981 agtctctttt tgccctttga caattgaata attctaggtg ggactttatt tatttgttga
    14041 gcaatagaat gtaatgcgcc aggaaatgag cggaaatcat ttattcaaaa ataggatggt
    14101 gacctatctg ccatgacaca aataatgata atgatacttc tgaccgttca ggctgccaac
    14161 gtaaaaggac agcgggtgaa attcccatga ttgatataac cagtcatacc cacagagaat
    14221 aactaagagt aacatgttat caggagggta agttttggaa caatcagtag taaaatatag
    14281 tatgcaactt tcaatgctta attttttata ttccagaaat atgttgacta aaaaggaata
    14341 tgaaaaaatt aaaaatagac tgcgcattaa gtacacaaat tagctgacct tttgatttga
    14401 acgcggtaat atagaatcaa aaggaggaat ttcagtatga aaaaaaataa tgttgaaata
    14461 ataaaagctg attctttagt tcgtcgtaga ggcgacaatt tcgaaagaga gtcaaaaagg
    14521 gttgctgctt attgccgagt tagttctgat agcgaagatc agaagaacag ctatgaatct
    14581 caggtgagac attataaaga ttatatctct cagcggtcgg attgggaact ggcaggtatc
    14641 tatgcagatg aggggatttc aggaacacaa gtaggaaaga gacaagattt tcaacgatta
    14701 ataaatgatt gtgtaaatgg agaaatagat tacattgtca caaaggcaat tgctagattt
    14761 gccaggaata ccctagatac tttgaaatat gtcagaatgt taaaagatat gcaaattgga
    14821 gtatattttg aggaagaaaa tatagatacc ctaacaatgg atggagaatt gcttttgact
    14881 attctaagct ccgttgcaca gcaagaagta gaaaatacat ctgctcatgt gaaaaaagga
    14941 ttaaaaatga agatgcaacg tggtgaattg atagggtttc aaggatgctt ggggtatgac
    15001 tatgatgtag aaaccaagca actttcaatc aataaaaaag aagccaaaat agttcgctat
    15061 atctttgaaa ggtacttaga aggtattgga ggaaaagtaa ttgcaaggga acttgatgaa
    15121 ctaggttaca aatcgccgag aggattagat cattggaatg atacaacagt cttaggaatc
    15181 ataaagaatg aaaaatataa aggcgatatt ctaatgggca aaacttttac agtggatcca
    15241 ataagcaaga gacgtttaag taattttggt gaagaagata agtactacat caaagataat
    15301 catgaaccta taatatctaa agaagacttt gagaaagctc aggagataag acttcgtcga
    15361 gcaggaaata agaagactgc tgcaaatgta aatggcaagc gtgaacgcta ttcaaaaatg
    15421 tatgctttta gtagcatgtt agaatgtggt ttttgtggtt caatattatc tagaagaagt
    15481 tggcactgcc gttcagatta tcgcaaggtt gtgtggcact gtgttacatc gataaagaaa
    15541 ggaaagaaat tttgtaagca tagtaaagga ttagaagagc tcgctattga gggggctttc
    15601 atggaagctt acagaaaact ttatcattca aatgaaaact taatgacaga cttacttgaa
    15661 acgattgaat ctgaattgaa tgacaatagc cttaataagg aactaaaaaa ggattacaaa
    15721 caaacttcga acattactaa aaaaagagga aaatcttgta aatctaaggc tcgaagggaa
    15781 aattagcgat accatataca atgaaaagta caatgaaatt tcctcagaaa aagagtttct
    15841 agcagaagag aaggtaaata ttgaaacaac cttaaaatca gaaatcgatg taaagaaaag
    15901 actaactgag tttaagcact tgctatcttc acagaaaatg cttacggagt ttgatcgtgc
    15961 agtttttgaa agtattgttg agaaaattat tgtaggtgga gttaatagcg acggagaaat
    16021 tgatcctgca atgttaacca taatattcaa aacaggtgaa actcaaaaca aggatggtaa
    16081 acaatttaaa agtaaacgta aaaatgctaa actagaaaca gataaattgt gtcctcaaaa
    16141 cagtgacgag gataaaaaat tgtattctca aggaacagac tacacacgtt gaggcagtat
    16201 cactgcttgt acgagttggt ggaacagcga agtagaagca gattgttctg cccatgcgat
    16261 aattgtcgta gaatgaggag ttaacgacga aatgagacgg taacagcgaa ccgttgagtg
    16321 cgtagctcta cttgtaaaat tctagaaacc tttgaatgaa agggataatg aaaagccttg
    16381 gttgcaaggt tttttgtcgt atggagaaga agtatcagag taagaatcca agtagagtgt
    16441 cttgatgtga tagcgtgata ggttatcaat ctatttccac aaaccctgag agtatggact
    16501 tgtttccaca gaagaggagt ttgtggaaat gaacatatcc cttacattat tacctagatg
    16561 gtcgttgaag tttgagttct atatattgat actacatatt ttaaagttag tatttttaaa
    16621 tcagtaaaat aatatcctta ttttaaaatt tagagaaaag taatataata gtagaaaaga
    16681 agagagttcg tggatgttaa taaatataat cttgtttaca atcagaatat tgccgagaat
    16741 agtcactgtc ttttaaaagc tttattcgta aaaggtatag aaatataata ttttttgaag
    16801 aggtaaagga aaaaataaga tctgtttaat ttagggtact gataaatcag gatggaggtg
    16861 tttttttgag aacatatgaa aataaagagg agctaaaaaa agaaataagt aaagcatttg
    16921 agaaatatat tttggaattt gataatatcc cagaaagcct gaaagataaa agaattactg
    16981 aagttgatag aactccagcc gaaaaccttt cgtatcaggt tggatggaca agtttggttc
    17041 ttaaatggga agaagatgaa agaaaggggc accaagtaaa aacaccatcg gatgaattta
    17101 aatggaatca acttggtgag ttatatcagt ggttcacgga tacttacgct catttatctc
    17161 tgcaggagtt gaaagcaaaa ttaaatgaaa atattaattc tatctatgca atgattgatt
    17221 cgttgagtga ggaggaatta tttgaaccgc atatgagaaa gtgggccgat gaagcgacta
    17281 aaacagcgac ttgggaagtg tataagttta ttcatgtaaa tactgttgca ccttttggaa
    17341 ctttccgaac taaaatcaga aaatggaaga aaatagtatt ataaattata ttttttaact
    17401 ttaaaaaatt tcataaaaat ggttaccaaa ggcgataaaa gaaaaaacta tcgtcttttt
    17461 ttttataaat tattagaacg attaaaaatc agaggaataa tttcattccc caccaaacct
    17521 ccaccaaagt ttaggttttg gtaggaagtt gcttaatttt gtaaaagcaa tccatctaac
    17581 gctctagtta aatgtttata aaaagaagca aaaagcaatt tcattttact tgagagaagg
    17641 atttttaatt atttctgaga atatagatga taatactcag gaattagaat tgtctataac
    17701 atggactaat ttgtaatgga gaatgaggaa tgtcaaaaga cattaatagt agactgtaca
    17761 tttaagaagt ttttgaaagg ttttaccaaa tttatgcttc tgcacgtcaa gaagtattag
    17821 atttagttaa tttatcaggt acttttattc cgcttaatat cgattccgat agagagggat
    17881 tacttgacta ttagattctt gtggcagaaa ttgcagggat aatagttggt tttactgtat
    17941 ttacagtaga taattagcat ggctatatgt agataggaaa tttattcgac aagggattgg
    18001 gacaaggtta gttgatggtg ctttcaagca gatgaataat actatttcaa ttgaagtttt
    18061 agcaggaagt attcttgagc ttacatttta caaaaaattc gaatttgaaa ttgtaaatat
    18121 aaagacaggt cgaatgccag gaaatgaaga gttttcagtt tccgtaaatg atttgaggag
    18181 cagagttagt aagtctgaac atatttttgt ttttatatgc tataatcatc atagagcagt
    18241 taataagaaa cgagaataat atgttagttg ataaattaca agagcagtct gatttgactc
    18301 ctcaagagca agtggttgcg tcctttattt tggagaacat gaaaatgatt ccctcctttt
    18361 ctgctcaagg attggcagga aaatcattta ctagtaaggc aacggttgtt cgtctgtgtc
    18421 aaaaactagg tttttctggg ttccaagagt tcaaattaca attgttagca gaatggcatg
    18481 aaaagcaacg acttgatgca ttattgtcag aggagccaat ttcttcccat acaaattttg
    18541 aggatctcct agatattctt ccgcagattt atgataaagc tttaaccaat actagattta
    18601 ctttaagaaa gcaacaactt ccaaaactta taaattttat tgaaaaatcg gatcagataa
    18661 tttttttagg gactggtatt tcgtatatct cagcacaagc tgctgcattt aagttttcaa
    18721 atttagggct acaagcaacc gctatggaat ctcttaataa gcattttctt gcactcaata
    18781 aagataagaa aacagtattt ttccttatca gctttactgg aaaaaacgag tccattcttc
    18841 agatggcacg ttatttaaaa caggaagggt tttgtcccat tgttggatta gttggtcctt
    18901 attatgaaca attaaaacct tactgtcatg agattataga attgcctaat cgtgaaagct
    18961 tgattggttt ggatgttgtc agtagtaata tcagcttgac gtatattatc gatcttctat
    19021 tttcaatgta tctagccaaa acatatgata aacaagtcaa agtaaaccta tctaatcgac
    19081 caaaataaac cacattgaac ctttgttaca gaaaacaaag gtttttttaa atgattactg
    19141 gaccatttga ccaaaatatt gaaataaaat tgtaagcgtt atctgaagtt gttatactag
    19201 ctctgtcaaa aagacattag ggaggaaaat atgaaaaaat atcaagcctt agcacaagat
    19261 attgttgagc atatcggtgg aaaagataat gtcacaggac ttgttcactg tatcacacgc
    19321 ctacgcttta atttagttga tgaatcaaaa gcagatgatg attatctaaa ggcactagat
    19381 ggcgttgtaa ctgtcatgaa aagtggagga cagtatcaag ttgttatcgg taaccatgtt
    19441 gcagatgtct atgaagaagt tctgcctttg ctgaatatta cagattctaa agtaagtggt
    19501 cagccagtaa atgtaaaatt attcgacaga atgatcgata cgatttctgg aatttttcag
    19561 ccagttctag gcattatggc tgcttgtgga atggttaaag gtttcaatac cttgtttgtt
    19621 accttaggtt tatatgaaaa tactagtggt gtctatcaga ttttaaatgc tgttggagat
    19681 gctatgttta cctttatgcc tctgtttcta ggatatacgg cggcgaaaaa atttaagttg
    19741 aaaccaatgc ttggtttagc aattggagcg gctctctgtt atccagcgat tcaagcaagt
    19801 agtttatccg caaattcaga agctttgttt actctatttg aaggtagcgt tctagcatca
    19861 ccagtctata tcaattttct tggcatccca gtaattgcga ttgattatac aggaacagtt
    19921 attcctgtta ttctagcagt ttggtttgct tcaaaatgtg aatgggtata taatcgtctc
    19981 attccagact tggtgaaatt cttctttgtg ccaatgttga cgatgttaac cgttattcca
    20041 gtgactttat tggtattggg tcctctggca acatttggtt caaccttaat ttctcaattt
    20101 acccttgctg tgcgtgacat cagtccactt ttagcaggtg cgttagtagg ggcaacttgg
    20161 caaattctaa tcatttttgg tcttcattgg ggctttattc cagtgtatat taataacgtg
    20221 atgacattgg gttatgataa tgtcatgatg ccattctttg cttgtacctt tgcaacatcg
    20281 gcggtagtgt tgggcattta ttgcaagact aaaaatcaga aattaaaaga gatggctatt
    20341 cctaacttta tatcaggaat ttttggtatt acggaaccag ctatttacgg gatgttgtta
    20401 ccattaaaaa aaccatttat tatcagctgt atcgcaggag gaattggtgg tgctttctat
    20461 ggacatttca attttagaaa atttatcatg ggtggtatgg gaattttcga attgcctaat
    20521 atgatgaatc cagatggaag catggggaat attattgttg cttttgtagg gattcttatc
    20581 tcgatggttg tcgggttgat cttaacttta atgttctata aagaagatga attagtgcag
    20641 aatgagtcag aagaaaaaga tactattctt ttaagccctt tagagggaga agttgttcca
    20701 ctagaaagta ttgaagacca aacttttgct tctggaatgc tgggaaaagg tttagcaatc
    20761 attccaagtc aaggaacttt aaaatctcct gttgatggtg agattatagc attatttcca
    20821 actggccatg ccataggatt aaagagcgat agtggaattg aaattttgat tcatattgga
    20881 atggatactg tgcagttaaa tggtagaggc ttttcaacta aagtgactgc tggtgaacac
    20941 gttcaaaaag gtcaagtatt aatagaattt gatcagaaac ttattcaatc ggaaggctac
    21001 tcgctggtaa caccagtgct agttacaaat tgggaagagt tttctgatat gacgattgag
    21061 aatcaacagg atatcgcatt tggtcaaaag atgatctctg ttagaaagta gatagtatgg
    21121 acaatgaatt tttatgggga gtagcaacag ctgccaatca atgtgaaggt ggtatagaac
    21181 aacgaggtaa ggcattagtt gatgttattc catttggaga gcagcgtttt ggtgtcatga
    21241 aaggtgaaat ctgtcataac acccttcaga atgataccta ttttcctgga aggcaagcaa
    21301 tcaatatggc agagaactac gatacagaca ttgatttatt aatagaatta ggaataaatg
    21361 cttatcggtt atccttttca tggtcacgta tttttccaaa aggtaatgaa gataaaccga
    21421 atcctagtgg tttagctttc tatgataaga ttattaataa gcttttagac aatagtattg
    21481 agccgatagt aactatttgt catttcgact tacctcttta tctggtagaa gaatttggcg
    21541 gatggggaga taggcaggtt gttgattatt atttgaatta ctgtgaagtc ttattccagc
    21601 attttaaagg acgcatcaag tattggataa cctttaatga aatcaatatg attttacatt
    21661 taccattctt agccgcaggt ttgtatgtat cagataaatc ttaccctctg gagtacattt
    21721 atcaagcagc acaccatcag ttaattgcct cagctaaagc gactaagtta tctcatgaaa
    21781 tttcaaaaga gaataacatt ggttgtatgc tagcagctgg aaaggtttat tcctattcag
    21841 caaatccaga agatgtttgg ttagctttgg aaaaagatag ggaaaactat ttctttacag
    21901 atgttcaagt caggggagag tatcctactt atgcacaaaa gtttttcaaa aggaatgaca
    21961 tcaatttgtt gattcctgag gaggatttac tattactaaa agaatacacg gtagattata
    22021 tcagtttatc ttattacaat agtcgttgcg tatcagctga tgcttcttta gcaacgaatt
    22081 cggggaattt attcgcatct gtttcaaatc cttttttgga gacgagtcag tggggatggc
    22141 caatcgatcc gttgggtttt agaatcacat tgaatgaatt atatgatcgt tatcaaaaac
    22201 ctttgttcgt tgtagaaaat ggtttgggtg cgattgattc tttggatgaa cataatgaga
    22261 ttgatgatac ctatcgtatt aactatttat cagatcatat tactgcccta ttaaaggcaa
    22321 aagatgagga tggtattcct atattaggtt atacgatgtg gtctgggatt gatatcatta
    22381 gtgcaacagg aggacaaatg tcgaaacgat acggtttgat atatgtagat atggatgatc
    22441 aaggacaagg aaccttgaaa cgaataccaa aagcttctta tcgttggtat cgagaaatga
    22501 ttagagagaa ccgttagata gataattaaa ccagccgagc aa
//
