LOCUS       NZ_JAPDMW010000034     17215 bp    DNA     linear   CON 23-JAN-2024
DEFINITION  Paenibacillus alvei strain LF-11/2021
            NODE_34_length_24320_cov_32.140330, whole genome shotgun sequence.
ACCESSION   NZ_JAPDMW010000034
VERSION     NZ_JAPDMW010000034.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus alvei
  ORGANISM  Paenibacillus alvei
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 24320)
  AUTHORS   Fallico,L.
  TITLE     Analysis of the Paenibacillus alvei's inhibition ability against
            multidrug resistant bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24320)
  AUTHORS   Fallico,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2022) U.O.C. Microbiologia, Ospedale San Bortolo
            AULSS8 BERICA, Viale F. Rodolfi, 37, Vicenza, Vicenza 36100, Italy
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.14.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 71.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/23/2024 02:12:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,998
            CDSs (total)                      :: 5,902
            Genes (coding)                    :: 5,824
            CDSs (with protein)               :: 5,824
            Genes (RNA)                       :: 96
            rRNAs                             :: 9, 1, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9 (5S)
            partial rRNAs                     :: 1, 8 (16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 32 of 78
            Pseudo Genes (incomplete)         :: 65 of 78
            Pseudo Genes (internal stop)      :: 14 of 78
            Pseudo Genes (multiple problems)  :: 27 of 78
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:37:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 17215
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPDMW010000034.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17215
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..17215
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17215
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4621:7215](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4622..7215
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            562..1752
                     /locus_tag="OF778_RS29455"
     CDS             562..1752
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015893747.1"
                     /locus_tag="OF778_RS29455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid deaminase/aldolase"
                     /protein_id="WP_268627746.1"
                     /transl_table=11
                     /translation="MRDYRYYKEVCTGLPMPFAFVDLDLLQQNIQSVLHRANGKKVRIA
                     SKSIRSVDVLRRILQANAQFQGIMCFTVPEALYLAQQGFTDLLLGYPATDARLFKSVAM
                     HQREGRSITLMVDCETHVEQAEAAAAKYGVRLPLCVDIDMSIDVPGLHFGVWRSPIRST
                     AAALSLIERIAQSKHVVLDGLMGYEAQVAGLGDRVPGQALKNVIVRLLKRRSIREAAAR
                     RAELVAAIERMGIPPLRFVNAGGTGSLHSSSSEPAVTEVTAGSGFYSPGLFDHYRDFTL
                     LPAAGYAIEIVRQPRSDLYTCLGGGYTASGAAGSDKLPRPYLPQGMALLTMEGAGEVQT
                     PIRYNGLEKLKLGDPIFMRHSKAGELCERFAHLYYISNGSIVGKTTTYRGDGLCFL"
     gene            1740..3077
                     /locus_tag="OF778_RS29460"
     CDS             1740..3077
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003885 - D-arabinono-1,4-lactone oxidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018754645.1"
                     /locus_tag="OF778_RS29460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="D-arabinono-1,4-lactone oxidase"
                     /protein_id="WP_268627748.1"
                     /transl_table=11
                     /translation="MLSVNLKERNTKVWRNWSGLVRGLPRSIVYPASIEEVVGIVKECA
                     AEGRKLRVVGSGHSFTRLVLTDDVLVSLDQLQGVIAVDSEQGIAEVWGGTKLDRLGKEL
                     HAYGVAQENLGDINAQSIAGAISTGTHGTGERLGSLATQAVGLTVVTAAGEILECSAQQ
                     DEELFRAMQVSLGMFGIIVKVKLRVVPSYALRYTSSKMPFSQCLEQLDLFKKENRHFEF
                     FWFPYTDIAQVKLTNMTDEVPGTPSRWSYWKVMLLENALFWLLSECCRFIPRLCKPISR
                     LSATSVPDVQEVGHSHLIFATPRLVRFYEMEYSVPADRMRTVLEEIRDAVDRHQFAVHF
                     PIECRYVQGDDIWLSPANGRDSGYIAVHMYRGMEYADYFAKVEEICRRNGGRPHWGKMH
                     TMRADQLHTVYPKWDAFLRLRKELDPSGIFLNPYLAEMLQQSEQAQ"
     gene            complement(3237..3959)
                     /locus_tag="OF778_RS29465"
     CDS             complement(3237..3959)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005544413.1"
                     /locus_tag="OF778_RS29465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_268627750.1"
                     /transl_table=11
                     /translation="MAIKVAICDDVPVFAKDIEDLMLEYDSSLFEIDIFYNPFRLIELL
                     KRNRYDLFILDIEFPNVSGIEIAEIIRKNNYTCPIIFITRFKEYMEKAFKVNTFDYILK
                     PATKDKLYPALNRAIKYLDLDDSKFMFTFNKVFYSLSFNEIIYFEKNKRSVLIHTPSDT
                     YETLLQTRALLSKVNHNFVQVHTSFIVNVRYVKQIRNNCVVSNLNDKQTVEIPISRKFI
                     DSARKQILMKLRECPLKA"
     gene            3996..4247
                     /locus_tag="OF778_RS29470"
     CDS             3996..4247
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OF778_RS29470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268627753.1"
                     /transl_table=11
                     /translation="MHHHVINNNLSEQRQRYYKKCKKETGKYVQASRNSLTDIAKELNI
                     PIGFLKMVGQCRQFKVEAFVGSGNLRPQNQAQKELKKG"
     gene            4443..4568
                     /locus_tag="OF778_RS29475"
     CDS             4443..4568
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017370910.1"
                     /locus_tag="OF778_RS29475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_174809185.1"
                     /transl_table=11
                     /translation="MTNVVYSKPTIEKIASFKESTKGIWFGRYRDVLGGRALTRI"
     gene            4622..6487
                     /locus_tag="OF778_RS29480"
     CDS             4622..6487
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="OF778_RS29480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_268627758.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.9e-25, bitscore:
                     80.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATFCEKLIVLEARMINLFKILGIARGETVISIQLKEKLTKLSSD
                     KVPFQVHIKTASASILLISQHKYVKHSIGDLEIYCIPCEYPKVSDQIQGTMNFEITKIA
                     GTFQKIVSKGIFVLVDNHEVIVGGALFDVSLSWKMLNDILIISDSASDIARYCDLHISK
                     SAVALNLISSLPYYPFQNMPLWEGVNKIHPFCVLRYGKKKQFEEFKVWMPPELSNDVEL
                     TLQNIRERFFELLRNHTSSYANISADLSGGVDSAAIAYTLKAQSADIKLYHAKTDSKWN
                     SDSKYAAMFANDMNEPLHSLPSIGVSGRRYETDMPYSGLTLPDSPVFWADTEGYVEKIV
                     NLNENYGDSVHFIGVGGDELFTPMPAYAWSIVRQNRMRGLSFGFQYCLLTRTSFLKNVS
                     NLMNNTSFKEALKTEIDIGFGYAKSRRKESHVDWSGKIAIPAWLAKEYHAPCYQIAMKT
                     VNEISGGLDSDRSKHQALESLLFQRRVLSQLNAIYGNRFTWLAPFLDPKIIESALSIPM
                     RYHIKSGMTKPMLYQATKGIVPREVFTRGFKGDYSTFLYQGYKESVKKNIHAVRDFKVV
                     ELGIVDPDILVSELSMPTALHNRIEAFERLSAVERWLHNAMSCPS"
     misc_feature    complement(4630..4643)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.21"
                     /tool="antismash"
     misc_feature    complement(6515..6529)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.54"
                     /tool="antismash"
     gene            6521..6769
                     /locus_tag="OF778_RS29485"
     CDS             6521..6769
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="OF778_RS29485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_268627761.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.7e-21,
                     bitscore: 66.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.4e-14, bitscore: 44.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIKRELKIIEQDTGAMIFDKSRGIYFQVNHVGKLLIQRLDEGK
                     TRNELVAELEKTFGLESAIAENDVNEFLSMLREVGLA"
     aSDomain        6524..6766
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_OF778_RS29485_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.20E-21"
                     /identifier="RREFam002.1"
                     /label="OF778_RS29485"
                     /locus_tag="OF778_RS29485"
                     /protein_end="82"
                     /protein_start="1"
                     /score="66.7"
                     /tool="antismash"
                     /translation="KKIKRELKIIEQDTGAMIFDKSRGIYFQVNHVGKLLIQRLDEGKT
                     RNELVAELEKTFGLESAIAENDVNEFLSMLREVGLA"
     gene            6769..7215
                     /locus_tag="OF778_RS29490"
     CDS             6769..7215
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="OF778_RS29490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_268627763.1"
                     /sec_met_domain="PF13471 (E-value: 5.9e-25, bitscore: 78.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIPLFPEQPGQVSNGARWHARLAILLSAPLNWLPPSMIEKIFSR
                     LTISYPSASKEQVQVIRDAVCTVSKRCRSQEGCLRRSLAVVVATWLKRRSVSWCTGYAL
                     EPFRAHAWVELNGIPVGEPDEISLYSKVISVPNFGEEIAEKYGE"
     gene            7205..9037
                     /locus_tag="OF778_RS29495"
     CDS             7205..9037
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="OF778_RS29495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_268627765.1"
                     /transl_table=11
                     /translation="MENNNPKPKELEQDERYEPIPRASLRQLFALTTGHKLEFFLVLML
                     GISSAILTLIQPNLVADLVKQSSSGFTVNSTLILLILVLSVSMILTTIQYYLLQKIGEG
                     VVFEARSNLISHLLRLPIFEYDKRSVGDLLSRVSGDSSRLRMALIQGTVALTSGSFIVV
                     GAAIGLALKDILLFLTALVTVCLAFIGIVFMSNIIQKASFRVQQELGKLSGLVERDLHA
                     IRTIRSTNSTSIEENKAKLQAEHLRKLGIRLAKIQSFMMPISNMSLQVCGLIVLGFGGY
                     RVSMGYMTIADLIAFALLLFIMIGPVGQIFGAFSGIGESLGAFARIKELLDLALETDND
                     TNPAITFSLNSSAQKGMVLFEKVSFGYNKLEFRADIAQKEEEMILKEVTLRAEYGKRTA
                     IVGPSGAGKSTILQLIERFYDPISGHIYVDGKDYRSYSREELRKRITYVEQNAPVVAGT
                     LRDNLLLGNSNVSDQECYDVLKEVNLSYLIERSSEKLDMKIGESGTTLSGGERQRLAMA
                     RSLLSKAKIVLLDELTSNLDSLNEIGLKKAIDKMRESKTVIVVAHRLSTIVDSDIIYVL
                     EHGRIVGSGNHNELLDKVPLYRELAKEQFLDKAI"
     gene            9373..9513
                     /locus_tag="OF778_RS29500"
     CDS             9373..9513
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OF778_RS29500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268627768.1"
                     /transl_table=11
                     /translation="MNKKNNAKHSSKQVKKKIGVPNLDAEFGAETGAGAASKGASQKAK
                     Q"
     misc_feature    9837..9851
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.79"
                     /tool="antismash"
     misc_feature    complement(9997..10014)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     misc_feature    complement(10018..10032)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.1"
                     /tool="antismash"
     misc_feature    10019..10032
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.92"
                     /tool="antismash"
     misc_feature    10019..10033
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     gene            10058..12343
                     /locus_tag="OF778_RS29505"
     CDS             10058..12343
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009590366.1"
                     /locus_tag="OF778_RS29505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-dependent DNA helicase"
                     /protein_id="WP_268627770.1"
                     /transl_table=11
                     /translation="MKDQVKIAVRPLVEYVYRSGDLDSGFRAGTALTEGTKAHQQVQRT
                     YGEADQKEVYLSAEIPCGDLMFVIDGRCDGLLVEEDGSVVIDEIKSTSGEIPQTLEDTY
                     PVHWAQAKCYAYMYAREHEPARMKIQLTYVQVATGEQRRFQQEAIFAELELFVRDVVEN
                     YAPYARMLRDHRITRDRSISGLDFPFASYRAGQRKLAGAVYKVIDEGVKLFAKAPTGIG
                     KTISTTFPAIKAMGTGQLEQFFYLTAKTTTRTAAEETFALMQSQGLQMHTVTITAKEKI
                     CFQDQVSCRKEDCPFADGYYDRINEAVLDILTNELLISRQIIEQYARKHRVCPFEFSLD
                     LAYAADGVICDYNYIFDPRISLKRMFAERKSRTALLIDEAHNLVDRAREMYSATLNKGD
                     FLSLQREYKELNAEVHKAAKAVNAFFIQLRKESDANVQITQEVPVQLVERAAAFILAAE
                     EELGSRQDTEQSQSLLQAYFATQNFVRISKLYDERYVTYAEISSREVSMKLFCLDPSHL
                     LREMGKGFRSHIFFSATLTPMSYFRDMLGASPEEDYTLSLPSPFFREQLEVQIEPLSTR
                     YHDREGTKLELVRLLGQMITDRPGNYLFFFPSYAYMNLVYEAFAAAHAGDANLRLLLQR
                     GDMAEEERESFLSAFDAGNEGTLIGFAVMGGVFSEGIDLVGDRLTGVAIVGVGLPQIGL
                     ERDIIRDYFNAQGKNGFDYAYVYPGMNKVLQAGGRLIRTETDQGQLLLIDDRYLHPHYA
                     ALMPDEWK"
     gene            12626..13435
                     /locus_tag="OF778_RS29510"
     CDS             12626..13435
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019408.4"
                     /locus_tag="OF778_RS29510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1629 domain-containing protein"
                     /protein_id="WP_268627773.1"
                     /transl_table=11
                     /translation="MKIWKMLSSLKSMEIEMENDEDFDVLYDGYGKFIEEWGTPKVVVT
                     KKGRYQDFPILSGGNVVFNQKSMDKLGDLLINNAQILDVNVNKSDIDLKIVHVLHLLDA
                     VDYNRSIPHRTLGGIVNGFNKLIFNEEAITSHDIFKIPELFSSVFVSDKFRDTVLASKL
                     KGFEFYEVWDSEITEEMEKEDQLRYEAFLDDLERNKGAEMSWSDAVACIEKGKAVASGH
                     WKLQFDKRGEMRVGRLSLDCKYSWSSSPFIPPLLLTLVWHEVAMSDI"
     gene            complement(13486..14346)
                     /locus_tag="OF778_RS29515"
     CDS             complement(13486..14346)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676852.1"
                     /locus_tag="OF778_RS29515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="WP_065294031.1"
                     /transl_table=11
                     /translation="MSSQVPAVIAKIVSQSQKLTYGENQIANFVIHNPDFITRNTITAI
                     ANEIGVSETSINRFCKKVGFKGFNDFKIAFAQDAFYRDMQAKKKERREINPIDALALDY
                     NELIVNTSALVTEEQLRQVVDILKGARRIYIIGMFDSYLAAIALKNRLSIIGIMAEAIN
                     DSRAMKIAAAQCSKEDAVVAFSRSGSTKEIVETVAIAQVHQVKTVAITCYDSSPITENA
                     DLNIIVPDKISVNNSALMSNHITFLFVVDLIMSIFISSDKAYLKKKLDSEAVLASDQAM
                     TNYYL"
     gene            complement(14414..15133)
                     /locus_tag="OF778_RS29520"
     CDS             complement(14414..15133)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676851.1"
                     /locus_tag="OF778_RS29520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_268627776.1"
                     /transl_table=11
                     /translation="MPVQTLLPNSLAGLTGLSDEILGCMELCQDPLFHKIPPEKILYYV
                     HESLQAGRLAATTYKGLGIRRMCRDAGLRYEITEASGKFHNVSFRAQIDFSKSTPEIIL
                     YASSLEGMRSVCQEILGERLCGSAADLDLLVDIHLAHEFYHWLEYREKIFTNEKLERVE
                     VFKLGPYTRKSSVVQCCEIAAHAFCKELLGLPFLPNLLDYAYLIGEQQLAKGDFMEQIE
                     TCKLWIGRTLNTSLSMI"
     misc_feature    complement(15122..15137)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.41"
                     /tool="antismash"
     misc_feature    complement(16278..16293)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.72"
                     /tool="antismash"
ORIGIN
        1 acttccaccg ggtagctcac tctagttgcc aacgcaaaaa cacctccaag gttgtcttca
       61 tatcttacga tataagaaca ttctcttgaa ggtgttttga tttgtctcac gttatggggt
      121 cagtcccagt cgcttagttg cggctttttt tattttcacg ataaatgttc ttgccaaaaa
      181 ccaatgacaa gaacatttat tgttttacgt aaatgaagac ggttttcaat ttcacatttt
      241 cgcttgggtc aaaactgaac ttatagtaat aacttcaggg gggcagggaa ctatgccttg
      301 aaaaatgatg cagactgagt aatggggtta agaaaagggt agtataatcc aacgtgttct
      361 ttaatccata aaaagggagc ccattatgtg ttcattttat atgatgtaga aaaattcaga
      421 cccagcctaa gatacgagct atctaaggct gggtcttttc gtataagaaa tggccttaga
      481 atctagaaat aataaattca aaggatctta aataataata taagaaatcg tgtatcttcc
      541 agacaaagga ggtcgagtag agtgcgtgat tatcgttact ataaagaagt ctgcacgggg
      601 cttccgatgc cctttgcctt cgttgatctg gatctgttgc agcagaatat tcagagcgtt
      661 cttcataggg cgaatggaaa aaaagtccgc attgcgagca aatcgatccg ctctgttgat
      721 gtgcttcggc gcattctaca ggcaaatgcg cagtttcaag ggatcatgtg cttcacggtg
      781 cccgaagcac tctatcttgc gcagcaagga ttcaccgact tgctgctagg ctatcctgcg
      841 acggacgcac gacttttcaa gtccgtcgcc atgcatcagc gtgaagggcg cagcattacg
      901 ctgatggtcg actgcgagac gcatgtcgag caggcggaag cggcagccgc caaatatggc
      961 gtgaggctgc cgctctgtgt ggacatcgat atgtcgatcg atgtccctgg gctgcacttc
     1021 ggcgtatggc gctcgccaat acgctctaca gctgcggcgc tcagcctcat cgagcgcatc
     1081 gcgcagtcga agcacgtcgt tctcgacggg ctcatgggct acgaagcgca ggtcgcaggc
     1141 ttaggcgacc gcgtgcctgg gcaggcgctg aagaacgtga tcgtgcggct gctcaagcgc
     1201 cgctcaatcc gtgaagccgc tgccaggcgg gccgagctgg tcgcggcgat cgagcgcatg
     1261 ggcatcccac cgctgcggtt cgtgaatgca ggcggcacgg gcagcctgca ttcaagcagc
     1321 agcgagccgg ccgtcaccga ggttacagca ggctcggggt tctattcgcc cggtctgttc
     1381 gatcactacc gggacttcac cttgctgccc gccgcagggt atgcgatcga gatcgtgcgt
     1441 cagccgcgca gcgatctcta cacttgcttg ggcggcggat acacggcttc gggtgctgca
     1501 ggcagtgaca aactgccgcg tccatacctg ccgcaaggta tggcacttct tacgatggaa
     1561 ggggcaggcg aagtgcagac accgatccgc tacaacgggc tagaaaagct gaaactcggt
     1621 gatccgatct tcatgcgtca tagcaaagca ggagagttat gtgagcgatt cgcacatctc
     1681 tactacattt cgaacggcag tatcgttggc aagacaacga catatcgggg ggacggacta
     1741 tgctttctgt aaatttgaag gagcgcaata cgaaagtatg gcgcaattgg tcaggactcg
     1801 tgcgcggatt gccaagaagc attgtatatc cggccagcat agaagaggtg gtcgggattg
     1861 ttaaggaatg tgccgctgaa ggacggaagc tgcgtgtcgt cggctccgga cattcattta
     1921 cccgactcgt cctgaccgat gatgtattgg tctccttgga tcaattgcag ggtgtaattg
     1981 ctgttgattc ggagcagggg attgccgagg tgtggggtgg aacaaaattg gatcgactcg
     2041 ggaaagaatt gcatgcctat ggggtcgcgc aagagaatct gggcgatatt aatgcgcaat
     2101 ccattgcagg agcgatcagt acaggaacac atgggacagg ggagcggctc gggagcctcg
     2161 caacgcaagc ggtaggtttg acggtagtga cagcggcagg ggaaatcctc gaatgctcag
     2221 cccagcagga tgaagaactt tttcgggcga tgcaggtgtc acttgggatg ttcgggatta
     2281 tcgttaaggt gaagcttcgt gttgtacctt cgtacgctct ccgctataca agcagcaaaa
     2341 tgccattctc tcaatgcctt gaacagcttg atctattcaa aaaggaaaac cgtcatttcg
     2401 aatttttttg gtttccttat acggatatcg ctcaagtaaa attgaccaat atgacggatg
     2461 aggttcccgg aacgccaagc cgctggagtt actggaaagt catgctgctg gagaatgcgc
     2521 tattctggtt attgtcggag tgctgtcgtt tcattccgcg cctttgcaag ccaataagcc
     2581 gattatcagc aacaagcgta ccggatgtgc aggaagtggg gcatagtcac cttattttcg
     2641 cgacgccgcg gctggttcga ttttatgaaa tggagtacag cgtccccgca gaccgcatgc
     2701 gaactgtgct tgaggaaata cgcgatgcag tagaccggca ccaatttgct gttcattttc
     2761 caatcgaatg ccgttatgtt cagggagacg atatatggct cagtccggcg aatggacgtg
     2821 attctggcta tatcgctgta catatgtacc gtgggatgga gtatgccgac tattttgcca
     2881 aagtagagga gatctgcaga cggaatggtg ggagaccgca ctggggcaag atgcacacga
     2941 tgcgcgctga tcagctacat acggtatatc cgaagtggga tgcatttctt cgccttcgca
     3001 aagagcttga tccttcgggc atattcttga acccttactt ggcagaaatg ctgcaacaga
     3061 gcgagcaggc gcaatagctg acagtaatgt aacgaatcct tgatgattca cacaaacaaa
     3121 gccccgaacc cggtaaggat tcgaggcttg gaacatgatt catgagcaaa tcacacccgc
     3181 aacgactaag cgcatcgcgt ccgaccacgt tgtggcgttc aaaaggtctc tttaatttag
     3241 gcttttaaag gacattctct tagcttcatc aaaatttgtt ttctggcact atctataaat
     3301 ttacgactaa ttggtatttc aacagtttgc ttatcattta aattggagac aacacaatta
     3361 tttctaattt gttttacata tctaacatta acaataaacg aggtgtggac ttgcacaaaa
     3421 ttatgattaa ctttggataa aagggctctt gtttgaagaa gcgtttcata tgtatcagag
     3481 ggagtgtgaa taagtacgct ccttttattt ttttcaaagt aaataatttc attaaaagaa
     3541 agactgtaaa aaactttatt aaatgtaaac ataaattttg aatcatctaa atctaaatat
     3601 tttatagcgc gattcaaggc aggatatagt ttgtctttcg ttgctggttt taaaatgtaa
     3661 tcaaaagtgt taaccttaaa agccttttcc atatattctt tgaaacgtgt aataaagata
     3721 attggacaag tataattatt ctttctaatg atctcggcaa tctctattcc tgatacatta
     3781 ggaaactcaa tatctaaaat aaacaaatca tatctatttc ttttaagtaa ttcaattaaa
     3841 cgaaacggat tataaaatat atcaatttca aataaagagg agtcatattc taacattaaa
     3901 tcttcgatat cttttgcaaa aacagggaca tcatcgcaaa tagcaacttt tattgccatc
     3961 gtttcactcc tttgataatg gtaagtgtag ctttgatgca ccatcatgtc ataaataaca
     4021 atttgagcga acagcgtcaa cgttactata aaaaatgtaa aaaagagact gggaagtatg
     4081 tacaggcaag tcgaaattca ctcactgata ttgctaagga gcttaacatt cctattggct
     4141 ttttaaaaat ggtagggcaa tgccggcaat ttaaagttga ggcttttgtt ggtagcggta
     4201 acttacgacc tcagaatcaa gcacaaaagg aattgaaaaa aggataaaag atccttttct
     4261 ctataaccaa ttattatact agaattgaaa tgatgtcaat tattacattt aacttgcagt
     4321 ttattacaca aaagaaaaat tgagtggaaa atagattact atctaaaaca aataggatat
     4381 taatttctat ttggaatgta atgtgggtga tgtgagcata taggtaaagg gggtggaatt
     4441 caatgacaaa cgttgtttac tctaaaccaa caattgagaa aattgctagt tttaaagagt
     4501 ctactaaagg gatttggttt ggtagataca gagatgttct tggtggtcgt gctttaacta
     4561 gaatataatc gacaattaat taagagagaa aagtggtcat tggacaattt tgagatgtcc
     4621 agtggccact ttttgtgaaa aattgattgt tttagaggct cgtatgataa atttgttcaa
     4681 aatattaggg attgcgagag gggagactgt tattagcatt cagttaaaag aaaagttaac
     4741 aaaattaagt tctgataaag taccattcca agtacatata aaaacagctt cggcaagcat
     4801 tttgcttatt tctcaacata agtatgttaa gcattctata ggcgacctag agatatattg
     4861 tataccatgt gaatatccaa aagtttcaga ccagatacag ggaactatga attttgagat
     4921 tacaaaaata gcgggaactt ttcaaaagat tgtttctaaa gggatctttg ttctagttga
     4981 taatcacgaa gttattgtag gaggagcatt atttgatgtt tctctatcat ggaaaatgtt
     5041 aaatgatatt ttaattatta gtgattcggc tagtgatatt gcgcgatatt gtgatttaca
     5101 tatatccaaa tcagcagttg cattgaactt aataagtagt ctaccctatt acccttttca
     5161 aaatatgcct ttatgggaag gcgtgaataa aatccaccca ttttgcgttt tgagatatgg
     5221 gaaaaagaaa cagtttgaag aattcaaagt ttggatgccg ccagaactaa gtaatgatgt
     5281 agaattgacg ctgcaaaata taagagagcg gttttttgaa ttactaagga atcatactag
     5341 cagctatgct aatatatctg ctgacctctc tggaggtgtt gattcagccg caattgcata
     5401 tactttaaaa gctcaaagtg cagacattaa gctatatcat gcaaaaacag atagtaaatg
     5461 gaatagtgat tctaagtacg ctgctatgtt tgcaaatgat atgaatgaac cgctacattc
     5521 attgccatca atcggtgtgt ctggtcggag atatgaaaca gacatgccat actcaggatt
     5581 aactcttccg gattccccag tattttgggc agatacagag ggctatgttg aaaaaatagt
     5641 taatttaaat gagaactatg gagattcagt tcatttcata ggtgtgggtg gtgatgaatt
     5701 gtttacacct atgccagcat atgcgtggtc cattgtaagg cagaacagaa tgcgtggttt
     5761 atcgtttggc ttccaatatt gtttacttac gagaacatca ttcctaaaaa atgtatccaa
     5821 tcttatgaac aatacatcgt ttaaagaagc actgaaaacg gaaatagata ttggatttgg
     5881 ctacgctaaa tcccgaagga aagagtctca tgtggattgg tctgggaaaa ttgcgattcc
     5941 tgcatggctt gcaaaagaat accatgctcc gtgttatcag attgctatga aaactgtaaa
     6001 tgaaatttct ggaggtcttg attctgaccg ttctaaacat caagcactag agtcattgct
     6061 gtttcaaagg cgtgtactaa gccaacttaa tgctatttat ggaaatagat tcacttggct
     6121 agctccgttt ttagatccaa agattattga gtctgcatta tctataccaa tgcggtatca
     6181 cataaaatct gggatgacta aacccatgct gtatcaagct acaaaaggaa ttgttccccg
     6241 tgaagtattt actcgaggct ttaaaggaga ttattcaaca tttttatacc aaggatataa
     6301 ggaatctgta aaaaaaaata ttcatgcagt tagagatttc aaagttgttg agctaggaat
     6361 tgttgaccct gacatactag tctctgaatt gtctatgcca actgctttac acaatcgaat
     6421 agaagccttt gaaagactat ctgctgttga gcgatggctt cataatgcaa tgagttgtcc
     6481 gtcataatgt ggaaatatta tttcagaaag gggaaatttt atgaaaaaga taaaaagaga
     6541 acttaaaata attgaacaag atactggggc aatgatattt gacaaaagta gaggaattta
     6601 ttttcaagta aatcacgttg gaaaactttt aattcaaaga ttagatgaag gaaaaactag
     6661 gaatgaatta gtggctgaat tagaaaagac ttttggttta gagagtgcta ttgcagaaaa
     6721 tgatgttaat gaatttcttt caatgcttag agaggtggga ctagcataat ggatataccg
     6781 ctttttccag aacagccagg acaagtatca aatggggcaa gatggcatgc taggctagct
     6841 atacttctat cagcacctct gaattggctc cctccaagta tgatagaaaa gatattttct
     6901 cgtctaacga taagttatcc atcggcttct aaggaacaag ttcaggttat tcgtgatgca
     6961 gtatgtaccg taagtaagag atgtcgaagt caagaggggt gtctgagacg ttcacttgcg
     7021 gttgtagtag caacgtggtt aaaacgaaga tctgttagtt ggtgtaccgg atacgcccta
     7081 gagccattta gggcacatgc atgggttgaa ttaaacggta ttccagttgg agagccggat
     7141 gaaataagtt tatattccaa agttataagt gtacctaatt ttggtgagga aattgcagaa
     7201 aaatatggag aataataatc ccaaacctaa agaacttgaa caagatgagc gatatgaacc
     7261 gattccaaga gctagtttac gacaattgtt tgctttaact acaggacata aattagaatt
     7321 cttcttggta ttaatgcttg gtatttcaag tgcaatttta acacttattc aaccaaactt
     7381 agtggcagat ttagtaaagc aatcaagctc aggatttaca gtcaatagta ctttaatact
     7441 tcttattttg gttttatccg tttctatgat tttaactact atacaatatt atttgttaca
     7501 gaaaataggc gaaggtgttg tttttgaagc acgaagcaat ctgattagcc atttgttaag
     7561 actcccaatt tttgagtatg acaaaagaag tgtaggggat ttgcttagta gagtgagcgg
     7621 tgattcttcg agactaagaa tggctcttat tcaagggaca gttgcattaa ctagtggatc
     7681 ttttattgta gttggtgcag caataggtct agctttaaaa gatatccttt tattcttaac
     7741 agctttagta accgtatgtc tggcatttat cggaatcgtt tttatgagta atattataca
     7801 aaaggcaagt tttcgtgttc aacaagaact cggaaaactt agtggacttg ttgaacgtga
     7861 tttacatgcg attagaacca ttcgttctac aaattctact tcaatagagg aaaataaagc
     7921 taagctacag gcagagcatt tacgaaagtt aggaatacgt ttagcaaaaa tacagtcatt
     7981 tatgatgcca atttcaaata tgagtttaca agtatgtggt ctgattgtcc ttggttttgg
     8041 cgggtatcgt gtttctatgg gatatatgac gattgcagat ttaattgctt ttgctttact
     8101 actatttatt atgattggac cagtggggca aatttttggt gctttttctg gaataggaga
     8161 atcacttgga gcttttgcaa gaattaaaga attattagat cttgctttag aaactgataa
     8221 tgatacaaat cctgcaataa cattttcact caattcttct gcacaaaaag ggatggtact
     8281 ttttgaaaaa gttagttttg gatataacaa attagagttt agagcagata ttgctcaaaa
     8341 agaagaggaa atgatactta aagaagttac tttacgtgca gaatatggga agcgcacagc
     8401 tattgtcggg ccttctggtg caggaaaaag tacaatttta caattaatag aaagatttta
     8461 tgatcctatc agcgggcata tttatgtaga cggaaaggat tatcgaagct attctcgtga
     8521 agagcttcgg aaacgtatca cttatgttga acaaaatgca cctgttgtag ccgggacttt
     8581 acgagataat ctacttttag gaaattctaa tgtatctgat caagaatgtt acgatgtttt
     8641 aaaagaggta aaccttagct atttgataga acgttcttct gaaaaactag acatgaaaat
     8701 tggagaatct ggtactactt tatctggtgg agaacgccag cggttagcta tggctcgctc
     8761 tcttttatca aaggcaaaga ttgttcttct tgatgaattg acatccaatt tagatagttt
     8821 aaatgaaatt gggttgaaaa aagctattga caagatgaga gagtctaaaa cggtcattgt
     8881 tgtagcacat cgtctctcga caatagttga ttcagatata atctatgttc ttgaacatgg
     8941 aagaattgtt ggttcaggta atcataacga gttactggat aaagtaccgt tatatagaga
     9001 attagctaaa gaacaatttc ttgacaaggc catttaaata aaagataaga gctatctaag
     9061 gctggatcgt tttgtgagca caacaacgtt ataggaaatc ccccaaaata agtccgtcga
     9121 acccagtcgc gtccgtctga acaacactta aattctttga tgaaatgaac tttcgatgac
     9181 tgactcttgg agctggaacc aagcggtaat caagcaccgt cgaataccaa aaactatgct
     9241 ttagacgtgc tgctcgcatg aacagcgcat agggtgaagc tgctcatcac ataatactac
     9301 ttgaggagac agtggttttc tcaaaccgtt cagataattg ccgattctca cgacatgagg
     9361 aggtgtaatg tgatgaacaa gaagaataat gcgaagcata gctccaagca agtaaaaaag
     9421 aaaataggtg ttccaaatct tgatgcggaa tttggggcag aaacaggcgc tggtgcagct
     9481 tctaaaggag cgtcccaaaa ggcgaagcaa tagactgttg aaattatgct tgccttgatg
     9541 caacgagatt tcggaaccgc ctgtccggac tggtgagaat ccggaaggat cttcggagta
     9601 cgagctgcga cttatcaagg agctgccgtg tccgtggaac cgcccgtccg gactggtgaa
     9661 tatttggaaa gacctccgaa atacgcttta gttagaacca ggtgaggcag cggctaccga
     9721 actgaaggac aatctattag atgcttcaga caataatgag tctttgtggt atccgaatga
     9781 tatacttgaa ataagtgata atagtctctc caatgcatgg ccgttcccgt ggaatcatca
     9841 tcaacgttga ttcataacta gggtagatta tgaaaaaaga tcgaatttcc gatttacgag
     9901 ctgacagcgt ccttgcgttc ataatgaatg caagggcgct gttttttttg tgaagaaagg
     9961 atttgttgaa aaaggttcat taaaagtaag gagaactaac cgttttatgg tatactatgg
    10021 aacaaatgtt ctatagcgaa agtcagcggg tgaagcgatg aaggatcaag tgaaaattgc
    10081 ggtgaggcct ttggttgagt acgtgtaccg cagcggggat ttggatagcg gtttcagagc
    10141 gggaacggcc ctgacggagg ggactaaagc gcatcagcag gtgcagcgaa cttacggtga
    10201 ggcggatcag aaagaagtat atttatcggc agagattcct tgcggagatc tgatgtttgt
    10261 tatagacggg cgctgcgatg ggttgttggt agaagaagac ggatccgtcg tcatcgatga
    10321 gattaagtcg acatctggcg agatcccaca gacactggag gatacctatc cggttcattg
    10381 ggctcaagct aaatgctatg cctatatgta cgccagagag catgaacctg ctcgaatgaa
    10441 aatccaattg acctacgtac aagtcgcaac gggcgaacaa agacggtttc agcaggaggc
    10501 aatttttgcg gaattggagt tatttgtacg ggatgtggtg gagaattacg ctccttatgc
    10561 acggatgctt cgcgatcacc ggattacacg ggacagaagc atcagcgggc tggatttccc
    10621 tttcgcttct tatcgggccg gacagcgtaa attggcaggt gcggtctata aagtgatcga
    10681 tgagggagta aaattatttg ccaaagctcc tacagggatc ggaaagacga tctcgactac
    10741 gtttcccgcc ataaaggcaa tgggaacggg acagcttgag cagtttttct atttgaccgc
    10801 caagacgact actcgtactg cagcggagga gacgttcgcc ctgatgcagt cgcaaggatt
    10861 gcagatgcat accgtaacca ttaccgccaa ggagaaaatt tgttttcagg atcaggtgag
    10921 ctgccgcaag gaagattgtc cattcgcgga tggttactat gatcggatta atgaggcggt
    10981 acttgatata ttgactaacg agttgcttat cagccggcaa atcattgagc aatatgcacg
    11041 caagcaccga gtttgtccgt ttgaattttc gcttgatctc gcttatgcgg cggatggggt
    11101 tatttgcgac tataattata ttttcgaccc tagaatttct ttgaaaagaa tgttcgccga
    11161 gcggaagagc cggacggcgc ttctgattga cgaggcgcat aatctggtgg atcgggcacg
    11221 agagatgtat tcggccacat tgaataaagg ggattttctc agcttgcagc gggaatataa
    11281 agagcttaac gctgaggtgc acaaggcggc caaggcagtg aacgccttct ttatacaact
    11341 gcgcaaagaa tcggacgcaa acgtacaaat tacgcaggaa gttcctgtac aactggttga
    11401 gcgggccgcg gcatttatcc tcgcagcaga agaggagctt ggctcccgtc aggatactga
    11461 gcagtcgcaa tcgttgctgc aggcttattt tgcgacgcag aattttgtga ggatcagcaa
    11521 gctgtacgac gaaagatatg taacctatgc cgagatttct tcgagagaag tatccatgaa
    11581 gctgttctgt ctcgatcctt ctcatctgct acgggaaatg ggcaagggtt tccgctcgca
    11641 tattttcttc tcggctaccc ttacgccaat gtcctatttt cgggacatgc tgggggcaag
    11701 tccggaggag gattatacat tatcactgcc ttctcctttc ttccgcgagc agctcgaggt
    11761 ccagatcgag ccgttgtcga cacgttatca cgatcgcgag ggaaccaagc ttgagctggt
    11821 gagactgctg gggcagatga ttaccgatcg tcccggaaac tatttattct tctttccttc
    11881 gtatgcttat atgaatctcg tctatgaagc ttttgctgct gctcatgcag gagatgcaaa
    11941 cttgcggctg ttgctgcagc ggggggatat ggcggaggag gagcgggaaa gtttcctgtc
    12001 ggccttcgat gctggaaatg aagggacatt gatcggtttt gcggtaatgg gcggagtttt
    12061 ctccgagggg atcgatctag tgggagatcg cttgaccgga gttgccatcg ttggtgtagg
    12121 actgccgcag atcggcctgg agcgtgatat catccgcgac tatttcaacg cgcagggcaa
    12181 gaacggattt gactatgcct acgtatatcc gggtatgaac aaggtactgc aggccggtgg
    12241 gcggctgatc cgtacagaga cggatcaggg acaattactg ctgatcgatg accgttatct
    12301 gcacccgcat tatgcggcat tgatgccgga tgagtggaag tgagcggtaa gaaaccatta
    12361 ttttgtccgc tgatcaaaga aaataaggtt gttgactaac gatcttgcta taacacaaat
    12421 ttgcgtaaga aaatctaggt tttagatttt tgccatcgag gagtctccaa atagacttga
    12481 tcaagaaaat aatgtgttag actgagagta aataagttac agaagttacc aacgtaacga
    12541 cctgcagccg gtatttatcc agcatcgcca ggattgtgat ctgcagttgt tcgatcgaga
    12601 atgtcagtcc ttaaaggagt cttttatgaa aatatggaaa atgcttagct ctttgaaaag
    12661 tatggaaatc gagatggaaa atgatgaaga ttttgatgtg ctttatgatg gatatgggaa
    12721 atttattgag gaatggggaa ctccaaaagt tgtagtaacc aaaaaaggaa ggtatcagga
    12781 cttccctatt ctttcgggtg gaaatgttgt tttcaaccaa aaaagtatgg acaagttagg
    12841 ggatttatta attaataatg cacaaatttt agacgtaaat gtaaataaat cagatattga
    12901 tttgaaaata gttcatgtat tgcatttgct tgatgcagtg gattataatc gctcaattcc
    12961 acatagaaca ttggggggaa ttgtaaatgg ttttaacaaa ttaattttta atgaagaagc
    13021 tataacttcc catgatattt tcaaaatacc tgagttgttt tcatccgtat ttgtctccga
    13081 taaatttaga gatacggtgt tggcttccaa gttaaaaggc tttgagttct atgaagtatg
    13141 ggattcagag attacagaag agatggagaa agaagatcaa ctgcggtatg aagcatttct
    13201 agatgatctg gaacgaaata aaggagccga aatgtcatgg tctgatgctg tagcttgcat
    13261 agaaaagggg aaagcagtag ctagcggcca ctggaagttg cagtttgata agcgtggaga
    13321 gatgcgggtc ggaagactta gcttggattg caaatatagc tggtcaagct cgccatttat
    13381 tccacccctc cttcttacac tggtttggca tgaagtggct atgtcagata tatagaaaag
    13441 cgccccttcc gtgatggaaa gagcgcttta ggaactttgt aatgttcata aataatagtt
    13501 ggtcatcgcc tgatcgctgg ccagaacggc ctcactgtca agcttcttct tcaggtaagc
    13561 cttgtccgat gaaataaaga tactcatgat caaatcgacg acgaacagga acgtgatgtg
    13621 gttggacatg agagcgctgt tattgaccga tatcttatcc ggcacgatga tgttcaagtc
    13681 cgcattctcc gtaatgggtg acgaatcgta acaggtgatc gcaaccgtct tgacctggtg
    13741 aacttgtgcg atcgcaaccg tctccacgat ttccttcgtc gagccggagc gggagaatgc
    13801 cacaacagcg tcctctttgc tgcattgtgc ggctgcgatt ttcatggcgc ggctgtcatt
    13861 gatcgcttcg gccatgatgc cgatgatgga caagcgattc ttcaaggcga tagcggccag
    13921 ataagaatcg aacatgccga taatatagat gcgccgtgct cccttcagaa tgtctaccac
    13981 ttggcggagc tgttcctcgg tgacaagcgc tgatgtattg acaatcagtt cattataatc
    14041 gagtgcaagc gcatcgatcg gattgatttc tcgtctctct tttttcttag cctgcatatc
    14101 ccgatagaag gcgtcttggg cgaaggcgat tttgaaatcg ttgaagccct tgaatccgac
    14161 ttttttacag aagcggttga tactagtctc cgatacgccg atttcattgg caatggccgt
    14221 aatcgtgttg cgcgtaataa aatccggatt gtgtatgacg aaattggcga tctgattctc
    14281 accatatgtt aatttttgcg attgggatac gattttggcg atgacggccg gaacctgtga
    14341 agacatgata cctcctcctg atctaacgct ggaaatgact actccggtgc gtgtctggca
    14401 atagcttttc ccattatatc atactgagtg aggtattgag agttcgccct atccataatt
    14461 tgcaagtttc gatctgttcc ataaaatctc ccttcgcaag ctgttgctcc ccgattaaat
    14521 aggcatagtc cagcaaattg gggaggaagg gaagtcccag cagctctttg cagaaggcat
    14581 gcgcagcaat ctcacagcac tgcactacgc ttgatttcct cgtatatggc cctaacttaa
    14641 aaacttcaac ccgctcaagt ttttcattcg taaaaatctt ctcccgatac tctagccagt
    14701 gatagaactc atgagccaga tgaatatcga ctagaaggtc gagatccgct gcgctgccac
    14761 ataacctttc gcctaggatc tcttggcata ccgatcgcat tccctctagc gaggaggcgt
    14821 acagaataat ttccggcgtt gacttggaga aatcgatctg tgcacggaag gagacgttat
    14881 gaaatttgcc agaagcctcc gtgatctcat aacgaagtcc ggcatccctg cacatgcggc
    14941 gaatgccgag gcctttgtac gtcgtagccg ccaagcgtcc ggcttgaagc gactcatgaa
    15001 cgtaatacag aattttctcc ggcggtattt tatgaaacaa tggatcctgg cacagctcca
    15061 tacaacctaa gatttcatcg gacagaccgg tcagaccggc cagtgagttc ggcaaaaggg
    15121 tttgaaccgg cattcgaacg cctccttaat gatccgcagt ttcattagaa atacaaggcg
    15181 ggcctcctat tactgataag ctacaaccag caattcatcc tctgctgcga gcatctcggt
    15241 ttcaatttca aggatggaca gcagctgctc tttggtctgc atgccggtta agtccagcat
    15301 cttctcctta taaaatacga atatcttcgg tatcgtggca ttggcatcgg aataaatggt
    15361 gttatcgtcc aagaatgagc ttagcgcttc cggcgctgat ttgctcagct tcgtatagtg
    15421 cacattgctc ttcttgaagc ggacgacgcc ttcacggtca agaacgctga cagagctgga
    15481 tttctttttg aacaagccaa aaaaagattt cttcacgttc tcgctgacga ataggctcca
    15541 acgcccggtc tgtgcggcga gtgttgtcga ctctagtggc tggtcgatgg agctggcagc
    15601 aacggtcctc atatcatccg ccgacattgc ttcctgtgtc agatccttgg agcgcagctc
    15661 ggtggagcca gtcgccatgg cacggagaat attcttctgg ctgtcgatct cgatgctgac
    15721 ttcgaccgtc tcctcggaag cgccagactg tacaatacgc tcgatgatgt cggcgcggat
    15781 gcgcttgata tcctcttcgg tcggattgac gaccgtccgc tctagctgtt ctttgaccat
    15841 ggctagcgct actccaattg tggatacata aggcgcattg ttggcgattt gcgatttgaa
    15901 gccttcacgc tccgccattg ccggaacgag caccgcaccg ctgccgccgc cgccaaccag
    15961 cgtgacgaag ctgcggtcga gttcatagtc ctcgatcatc tcgtttacgg tcttcatcgt
    16021 cttatcgatg gcaatattca taacctgtct agcggcttcc tctacgctta gtccaacatg
    16081 gtcggccagc gccttccagg atttcagcgc cgcttccttg tctcctctgg cataatcgcc
    16141 ttcgggaaca taattcagta tgttggccgc tccggctagt gtatacgaga attctttgcc
    16201 tccggcgcat tcgcagatga tgtattcggc agggtcgccc tcgcgggggc taatgaattt
    16261 caccttcgga ttgacgatgt tctctgtcgg ggtgaaggct tcgtactctt taccggcgat
    16321 atgcgcgctg cgtggcccga catctgtaat tcttccacct gccaccttga tcatgctgcc
    16381 gcccgcgatg ccgagcgtgc gcacatccaa ggattgcagg taggtgcggt ggccgccgac
    16441 ctcagcattc ttgatcatca ccttgccgtt cttgatcacg gagatgtcga cactggttcc
    16501 gccgacctcg aagaagattc cgtcggaaat cttctcgtac atcaacgccc cggcaacgcc
    16561 tgcggcaaga ccggatagca tcgttagaat cggacgcttg cgcacctcgt caatgctcat
    16621 gacaccgcca tcgcagcgca taatcatgag ttgggactgg atgttggcat ccttgacgga
    16681 cttttcggtc atattggcgg tctccatcat tttcggaatg agggaggcat taatgacggc
    16741 cgttcgtgtc cgtgtcttca aaccgtagag ctggctgatc tcatgtccgc ccgtagcgta
    16801 gagacccttg cggttggcaa gttcaacgac acgcagctca ttggttggat catctacgct
    16861 atacgcttcg gaggcgacga tcacctcggc gccctgggcc gccaactcgt cgatggcatt
    16921 gttgatctgc tcatctgtca tattcttgga atccagatac gtatgaaatg tgtgcaggaa
    16981 tttgcccgga gccagctcga tatcgcccgg attggactcg gagcgggcgc tgagcccgtc
    17041 gatgcccgag cccataccga tgatgccgat acgcgctaca tctccttcga gcagggcatt
    17101 ggtagcctgt gttgttccgt gggcgatgaa ggtaacgtct tcaggctgga tccctttgct
    17161 gtccagaatt cgctttagta tttgtacaat ccctttggcc acgccatccg ggtca
//
