LOCUS       NZ_JAPDMW010000006     20243 bp    DNA     linear   CON 23-JAN-2024
DEFINITION  Paenibacillus alvei strain LF-11/2021
            NODE_6_length_396361_cov_41.782273, whole genome shotgun sequence.
ACCESSION   NZ_JAPDMW010000006
VERSION     NZ_JAPDMW010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus alvei
  ORGANISM  Paenibacillus alvei
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 396361)
  AUTHORS   Fallico,L.
  TITLE     Analysis of the Paenibacillus alvei's inhibition ability against
            multidrug resistant bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 396361)
  AUTHORS   Fallico,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2022) U.O.C. Microbiologia, Ospedale San Bortolo
            AULSS8 BERICA, Viale F. Rodolfi, 37, Vicenza, Vicenza 36100, Italy
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.14.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 71.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/23/2024 02:12:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,998
            CDSs (total)                      :: 5,902
            Genes (coding)                    :: 5,824
            CDSs (with protein)               :: 5,824
            Genes (RNA)                       :: 96
            rRNAs                             :: 9, 1, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9 (5S)
            partial rRNAs                     :: 1, 8 (16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 32 of 78
            Pseudo Genes (incomplete)         :: 65 of 78
            Pseudo Genes (internal stop)      :: 14 of 78
            Pseudo Genes (multiple problems)  :: 27 of 78
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:37:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 315475
            Orig. end                         :: 335718
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPDMW010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20243
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="proteusin"
                     /region_number="2"
                     /rules="(PoyD or TIGR03793)"
                     /tool="antismash"
     cand_cluster    1..20243
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PoyD or TIGR03793)"
                     /kind="single"
                     /product="proteusin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20243
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10243](-)"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10243)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
     misc_feature    complement(1165..1181)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.1"
                     /tool="antismash"
     gene            complement(1231..2442)
                     /locus_tag="OF778_RS15085"
     CDS             complement(1231..2442)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542872.1"
                     /locus_tag="OF778_RS15085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_174807847.1"
                     /transl_table=11
                     /translation="METWKKNLWILWFGTFIVSSSFSMVVPFLPLFLIQIGVKDHIELW
                     SGILFSSVFFAGAISSPFWGAIGDKYGRKPMIIRAGIVLFVTYIMLAFVTNQYQLLTIR
                     ILQGLLTGFIPGSIALVGTSTPEKKVGYALSMMATATATGTIMGPLLGGILSKLFDSRL
                     TFACAGILCLIATLLVIFWVKEENFVPTKDSSSIVNTIRIASVNRPFMIVLLLSLLTQF
                     SVMTIEPVLPLYIVEIGHSAKDASLVAGFVFSLVGVASILFAARWGKLADRIGFQKVLL
                     IGLLAGGIGTLAQIPFQNIWWFSIIRFTYGIFFCAVFPALNGLVVRTTDSNFRGRAFSL
                     NQTANQFGGMLGPLVGGAISGVFSIHMVFWVTGILLLATMGLAFWTQRGDRVPVKAAGT
                     SKEL"
     gene            complement(2897..3739)
                     /locus_tag="OF778_RS15090"
     CDS             complement(2897..3739)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006284540.1"
                     /locus_tag="OF778_RS15090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,4-dihydroxy-6-naphthoate synthase"
                     /protein_id="WP_072730132.1"
                     /transl_table=11
                     /translation="MKIAYSPCPNDTFVFHAWAHGLIPGAPELDVTYADIDITNHLAAS
                     GNGLDVLKISFAALPWVLSEYALLPCGGALGRGCGPLVLTKESASTPADPSSLSGRRVA
                     VPSERSTAYLLFRLWAAQNVPGGVGEIVVMPFHQIMPAVRDGHIDAGLVIHEARFTYPS
                     YGLTMLADLGKWWEADTGLPIPLGAIIARRTLNVNAIAGWARASVEYAWAHPEASREYV
                     LAHAQEMSPEVTDAHINLYVNEFTRNLGEDGYAAVEALLGRAAKEGLVPAFDLAALRL"
     gene            complement(3742..4467)
                     /locus_tag="OF778_RS15095"
     CDS             complement(3742..4467)
                     /EC_number="3.2.2.26"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0009234 - menaquinone biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003345069.1"
                     /locus_tag="OF778_RS15095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="futalosine hydrolase"
                     /protein_id="WP_268625140.1"
                     /transl_table=11
                     /translation="MKEMKDASAAVSTVISAAEAAEQPTEGRILIVTSVAAERDALLRG
                     LQHHPQYDVILGGVGVAAAAARTARKLANEGSSNYRLVICAGIGGGFPGQAEIGSLVVA
                     SDIIAADLGAETPEGFSSLDELGFGSARIPVDAGLVAQVATALQAANLPARSGPVLTVT
                     TVTGTAATAAQMAERVPGAAVEAMEGYGVATAAQDFGLPVLELRAISNAVGPRNRAAWR
                     IQEALDALEAASAVLVEVL"
     misc_feature    4596..4613
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            4844..5599
                     /locus_tag="OF778_RS15100"
     CDS             4844..5599
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542867.1"
                     /locus_tag="OF778_RS15100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-ACP thioesterase domain-containing protein"
                     /protein_id="WP_268625086.1"
                     /transl_table=11
                     /translation="MVSNRWSEQHEVSSDNCDYKRDCRLSTLMEWMQRAGDSHLASHDV
                     SMDELVGSGMAWMLLTVDLELMRMPKYGDVLQLDTWHKGARGVQWLRDYVVYDAEHQQI
                     AQSRTTWALVDLNKRRILRASAFPYDVPVNNEDSVGEMPEKVAIPEESTLRLAYTLHVR
                     QSSIDMNGHLNNARFADICLDAMTLEELERGVSRFRITYHKEIILGDQVDVYRSTGEAM
                     HADDRRCFIRGQASDGSTLFDAEVVYREE"
     misc_feature    complement(5657..5669)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.35"
                     /tool="antismash"
     misc_feature    complement(5670..5690)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.98"
                     /tool="antismash"
     gene            5789..6937
                     /locus_tag="OF778_RS15105"
     CDS             5789..6937
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542865.1"
                     /locus_tag="OF778_RS15105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphodiester glycosidase family protein"
                     /protein_id="WP_227774817.1"
                     /transl_table=11
                     /translation="MQKLKKIITAVLGIALTFTFITPHGQAHADASSYGVMDTKAYRTY
                     VPIRYLSDKLHYQVTWEPTSKRIEVVSDDNYLEMTLGTTQAYVNGMNTELEAAPFRAGG
                     TTYVPVRFVSEAMNLSMEWDKNGSLVHFWNGDSHVRLPIVSKQRINQTSSIEKSWRAFK
                     VGNKRVTTTMLTINLLHPHIRLGVGVGYGGEGSVDNLKHMAKRNYAIAAINGGYFDAYS
                     NSKVKVPYGYVVRNGKMIHNGSGDKRSVLLFTKDNQVEMIPGPSFIDRFQEGDVYGALQ
                     VGPRLITDGKITVNLKGEGFKDPKILKHSSIRSAVGITKDYKLMILTTSSATIPELAKV
                     MKQAGAYQAMNLDGGASSGLYYNGRYMTYPGRNISNALLIFK"
     gene            complement(7005..7610)
                     /locus_tag="OF778_RS15110"
     CDS             complement(7005..7610)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288576.1"
                     /locus_tag="OF778_RS15110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_021255331.1"
                     /transl_table=11
                     /translation="MTTYIEEQYDGNDFSYVNWSESELRNCTFTSCRFRGAQLDGAVTT
                     SCQFIDCDFTGAVLNGSTHTHSAFTNCRFTGVNLFAAKFAECKMVGTDFTNVLWDGITI
                     IGGDWSYTNMRHANLTRQNLRGVRFMEADLTESKLEKADLRDADLTRTNLTKTKLAGAD
                     LRGAEMNGVNFKALELTKVRIDMIQAVAFARAYGAKVD"
     gene            7990..9921
                     /locus_tag="OF778_RS15115"
     CDS             7990..9921
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542861.1"
                     /locus_tag="OF778_RS15115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_174807849.1"
                     /transl_table=11
                     /translation="MGFKNWFTRGIFIGLIILVIGAITSPSLLSTQPEPTKITITQWDV
                     IWEKQQSAWKDIVRRTEGWETIDLQSSVPLKPQGSQSAWYRISLPPVHWDQPGLYISML
                     YGFEVDVYSDEGRKLYHSARDYGSDVYQILVPIRPSSNSQHVYIHTATTVERIGIQKSI
                     IIGNYQEIIQDYANQGLIDILLGSSLVFISIVMLICVFSLRNIDVPSWLSLNIVIMAVG
                     IIMITNSKFIHTYFGEYGKLTVILFDIAMQALSPALTYYFEQITGPGPFSITLKIRKFQ
                     VVYSILMLVCLFINILSNNQFYGFFYFITVKVYAVLIVGQLCLLTGLSIVYAIRKNVDA
                     ILFAIGFTVFAIVTLGELVWFLLHSGQYELTIWKWGVIAFIIAFIMIMGRRIVATHEQV
                     IQYSKELEMYNGKLQHSEKMHIISELAASVAHEVRNPLQVTRGFLQLMKNHSNDKEKEY
                     VKLALTELDRASEIITDFLTFAKPELEDVVILNVGEELRQIEGILMPLANMQGGVIELE
                     VESNLLIYGNSSKFKQVFINLIKNSIEALQDGGMIRIAGYEERGGIMICVQDDGVGMDQ
                     EEIARLGEPYFSNKTKGTGLGLMVTFRIVEVMQGSIHFHSEKGKGTEAIVRFPSALEQP
                     PITLHSGT"
     gene            complement(10001..10243)
                     /locus_tag="OF778_RS15120"
     CDS             complement(10001..10243)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proteusin: TIGR03793"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019422304.1"
                     /locus_tag="OF778_RS15120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP leader peptide family RiPP precursor"
                     /protein_id="WP_021255329.1"
                     /sec_met_domain="TIGR03793 (E-value: 1.7e-19, bitscore:
                     63.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTTEQLFKNQIIHKAWEDPSFKERLLKDPKAAIKEVLGISIPDH
                     VELTTQEETKDRFVLVIPPNPAETLPAEGVRRFVW"
     misc_feature    10212..10221
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.75"
                     /tool="antismash"
     gene            complement(10310..11248)
                     /locus_tag="OF778_RS15125"
     CDS             complement(10310..11248)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542857.1"
                     /locus_tag="OF778_RS15125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_268625087.1"
                     /transl_table=11
                     /translation="MHWYEPFRSEIEQVFQDAECIIEAFPAPLNDAGLRYIEKFNPSND
                     RSTNNYICYCLPYWMQDMTGLSTAHCRRLALASIFGMLYYFIQDDVMDNDCDNKAEQLA
                     LGNLCYIELLDIYRQMFPPQSPLWDSFRQYTWEWVHGVTSEREQDVFMTDRLKVAHKSA
                     LVKLSSSGALFLTGMEDKLPHVNEAVDTVLVCLQMTDDWADWQTDLQDGSYNCLLAWIR
                     FIQQIPTDKPLTEELVRHAITVSDILASFGQEALKLQAKLDGMPEASPQLVEFNRSLAK
                     ILVEEADHIRQQREVLMMGGLSYWLSNSVTK"
     misc_feature    11308..11324
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.74"
                     /tool="antismash"
     gene            11748..12596
                     /locus_tag="OF778_RS15130"
     CDS             11748..12596
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014372663.1"
                     /locus_tag="OF778_RS15130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EcsC family protein"
                     /protein_id="WP_268625088.1"
                     /transl_table=11
                     /translation="MGESRDELQQMLQAIEEWEREQKDLSIFEKIGRLPFALLDRFTPK
                     GIQNKIAELLDELGGYLHTGGSYLVQKKSILQKLRAKWAEEDPVSLAASTAQGNPLDLL
                     AVKQMPLALSNTVADSVRESNKKVAFAQGATTGFGGIFTLAVDIPAVLGIALKVLQETA
                     ICYGFDPDDPRERLFIVKCMQFTMSDIVGKQAVLQDIGDYDNPDRLRDSVSEVQGWRET
                     MVSFTDNFGWKKLFQSVPVIGMIFGSFMNRSMIHDMAETAQMLYRKRAVLERLNALDDC
                     C"
     gene            complement(12775..>12945)
                     /locus_tag="OF778_RS15135"
                     /pseudo=""
     CDS             complement(12775..>12945)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369241.1"
                     /locus_tag="OF778_RS15135"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="PAS domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="SRKKDVEDFWIPFKDKFVYFRYFAVRDESGEYMGTLEFTQNVSEI
                     RALEGQKPIMS"
     misc_feature    12983..12998
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.28"
                     /tool="antismash"
     misc_feature    complement(12983..13001)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 26.29"
                     /tool="antismash"
     misc_feature    12985..12999
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.25"
                     /tool="antismash"
     misc_feature    complement(12986..13001)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.16"
                     /tool="antismash"
     misc_feature    13047..13062
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.91"
                     /tool="antismash"
     misc_feature    13183..13197
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.34"
                     /tool="antismash"
     gene            13437..15182
                     /locus_tag="OF778_RS15140"
     CDS             13437..15182
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542851.1"
                     /locus_tag="OF778_RS15140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_268625089.1"
                     /transl_table=11
                     /translation="MKGRTLLFSHVRAHLPLYVTAVGCMALANFIYSVFPTLLGRFTDE
                     LQMRGLTKESVIHYSLWLLGVAIGYGSLFGIGQYLNHRLGRKFEFNMRQKLFTQFTRLS
                     EHYYSNHGVGKLLSYFMNDVTSVRETIANGVNQTTNATILLLSVIIMMGVSGIPLYLVF
                     VCVLPLLTIPLFVIYFGPRIRTRSRAVQDSLAAMTESAEEQFGGMKVTKTFAVEHVAEE
                     RFGATVDQICSNQLGLVRMTSLFQALIPFAGSLSLIIAITYGGVLSMQGQLSLGSFVML
                     TLYLRMIMTPLQQIGNVINVMLRSRASLDRLNRLLNEEPDIREYAGAQPISADDAVIEI
                     RNLTFAYREESRESLADVNIQISAGKTLGIVGKTGSGKSTLVKLLLRVYDPPKGTIRIG
                     GQDICEVTLESLRTQIGYVPQDGFLFSTTIRDNIAFYNRNAADEAVEEAAKQADVWDNI
                     MGFPDQFFTKLGERGLTLSGGQRQRTSLARGMIKNAPILILDDSVSAVDVVTETTILNN
                     LREVRKGKTNIIIAHRISAVRHADEIIVLDHGSIVERGTHEELIQSGGYYASLYTIQEE
                     GKRNA"
     gene            15175..17037
                     /locus_tag="OF778_RS15145"
     CDS             15175..17037
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542850.1"
                     /locus_tag="OF778_RS15145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_268625090.1"
                     /transl_table=11
                     /translation="MPEPTANVKGRNNHHPAQPKEIGSRMAGASPEERRQSFRAMFAYA
                     KPYRLTFLAIFLCTFLAIGADLLQPYLVKIAIDDHVLAGKHGVGTLFLIGGSYLLLALL
                     SLLFTYIQANLLQKVGQGIVGQLRKDLFRHISKQSMSFFDRHSMGSLVTNVSSDTETIN
                     QFFTQVLLSVVRDGMSLLLIVAFMFSLDAKLAMFCLILFPIILAIAVAFRKALRSAYQR
                     ARGELSRLIGFLAENLSGMGLIQAFHQEKEQTERFTAQNRKYLQENLREVRTSIMFNRS
                     FDVLGNVSVAFIVWLGGMAVLDTSLAFGVLYAFINYIRQFFQPINHITQQWNTLQSTIV
                     SMDRLWRIFRIQPEVQDPKPEQEHNVVASEVQGQVDFNHIRFAYVDDRDVLHDLDLHIK
                     PGEFIGIVGTTGAGKSSLVNLLARFYDVKRGSIEIDGVDIRRLPQHTLHQIVGLVQQDP
                     FLYSGSILDNVRLFQDTVSREEVIWACKSVGAHGLIKRLKHGYDTRLSDRGSGLSAGER
                     QLISFARILVFQPRILILDEATAHLDSHTEQLIQQALEVVSEGRTTLVIAHRLSTIQHA
                     DRIIVMRQGRVAEEGTNESLIAQNGYYAELIHHSRSYPRTAQQQ"
     misc_feature    complement(17260..17273)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.63"
                     /tool="antismash"
     misc_feature    complement(17309..17324)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.43"
                     /tool="antismash"
     misc_feature    complement(17311..17324)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.18"
                     /tool="antismash"
     misc_feature    17312..17325
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.28"
                     /tool="antismash"
     misc_feature    17364..17379
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.55"
                     /tool="antismash"
     misc_feature    complement(17366..17379)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.48"
                     /tool="antismash"
     misc_feature    17367..17380
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 20.78"
                     /tool="antismash"
     misc_feature    complement(17367..17382)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.03"
                     /tool="antismash"
     misc_feature    complement(17369..17382)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 20.78"
                     /tool="antismash"
     gene            17419..18888
                     /locus_tag="OF778_RS15150"
     CDS             17419..18888
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542848.1"
                     /locus_tag="OF778_RS15150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="catalase"
                     /protein_id="WP_268625091.1"
                     /transl_table=11
                     /translation="MSNPTKLTTNQGAPVADNQNSKTAGQRGPVLLEDYHLIEKLAHFD
                     RERIPERVVHARGAGAFGVFRPYQSMSKYTKAAFLQDPSIETKVFVRFSTVIHGGTSPE
                     TLRDPRGFAVKFYTTEGNYDLVGNNLPVFFIRDAIKFPDMVHSLKPAPHTNIQTPDHYW
                     DFMSLSPESTNMLTWLFSDLGIPANYREMDGFSVHAFKWVNEEGKVVYVKYTWKSLQGV
                     RSLTAEEAEHIQAKDFNHATRDLYESIEAEDFPEWDLYVQMIEPSQGDNFDFDPLDPTK
                     VWPEELVPMMKVGRMTLNENPANFFASVEQSAFSPSVLVPGIEPSEDKLLQGRLFSYPD
                     TQRHRLGTNYLQIPVNCPFAQVRNHQRDGAMNVNQDPSPINYEPNSHPGAYVEAGGQYA
                     ESEMLLDGTTMRRTISKTNDFGQAGDKYRSLTPEEQSRLIANLVNDLKQVRPEVQMRAL
                     CNFFRADAGYGARIAAGLGIDVSAHTQHMNS"
     gene            18939..19211
                     /locus_tag="OF778_RS15155"
     CDS             18939..19211
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542846.1"
                     /locus_tag="OF778_RS15155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcriptional repressor"
                     /protein_id="WP_021255323.1"
                     /transl_table=11
                     /translation="MNRNSMISFVQSDSKREPVHLTQQREAVLSFVNQAKSPATAIEIY
                     IGMRATTKRISLSTVYCSLKYFVKNGIVRELNEDHTSKRYECIAK"
     gene            19478..20155
                     /locus_tag="OF778_RS15160"
     CDS             19478..20155
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005542844.1"
                     /locus_tag="OF778_RS15160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine protein kinase"
                     /protein_id="WP_268625092.1"
                     /transl_table=11
                     /translation="MILNPEQLQSLIEQIELVLLPAADIRSLNGDDPVQVSNTPVDWEV
                     IGAGNYAVVFSHKQYASVAVKVYAAGRKGLDDEAEVYRRLGKHPAYSECYYVGQGYLIL
                     KRLPGVTLYHCLRHGISIPQSVLDDIDEALEYASARGLTPRDIHGKNVTNDCGKGYVVD
                     VSDFLIPQPDRMWGDFKRAYRLLYKPLGLKWGVPVPGWLLELLRKSYQIYRRRAAATGC
                     DKN"
ORIGIN
        1 ctatgcggat gcggtgatga tctgcacgca ggatcgcatg cattacgaag cgacgatgat
       61 ggcactggag cagggctatc acgtgttgtt ggagaagccg atctcgcctt cgcctgagga
      121 atgcgtcgag attgaggcag ctgcgagacg gtgcaaccgg atcgttcttg tatgctatgt
      181 gctgcgctac acaccattct ggtcctctat caagcaggtg atcgatgcag gcagcatcgg
      241 aaggatcgtg aatattcagt tatgtgaaaa tataggcttc gctcacatgg cccatagtta
      301 tgtacgtggc cattggagta agacgagcga gtccagtccg atgattttag cgaagtcatg
      361 tcatgattta gatattattc tgtggctcat gcagcaggat tgcaggcggc tgacgtcctt
      421 cggctcgctg ttccatttca agcgggagaa taagccggca gatgcgccgc tctattgtac
      481 agatggctgt ccgcacgtta atgaatgctg ttatgcagat ttgagatatt acttgggaga
      541 aggtcgtcgt cgtgcgctgc attttacgaa ggatccaaca gatgagcata ttcgggatgt
      601 gattcgtgag acgccttatg ggcggtgtgt cttccaatgt gacaatgatg tcgtcgatca
      661 tcaggtggtc aatatggaat ttcgcaacgg agctacggca tcctttacct tgtcagcctt
      721 cacgcatgac agctcgcgaa tagtgcaaat atcaggaacg agcggggaaa tacgcggtaa
      781 cctagagaag cagacattca tagtatatga ttttgttcat gatacttcac aagagatgca
      841 tgtccatgat gaggggcgcg aaggctgtac ggtcatgatg catgaatttt gccgtctcgt
      901 atcgtcgcgg ccacacaata ggagcgacct atcggctgtg ctgcgcggct ccgtgcagag
      961 ccacatgatg gcgttcgctg ccgaacgatc ccgattgcat gacggaatgc ctatggatat
     1021 tcagcagctg acgcgatatt accagcaggt agtcagcaag cccttggcag gtacatgttc
     1081 agagcggtaa tgttccaacg atcactcgat aaaaaagaga aggggctcac cgacgtatgt
     1141 aaaaattacg ttcggtgcag ccccttgtta ttgtagaacg atgattctgt cttccgcaac
     1201 gtaaacctgt aatttctgag aattacaggt ttacaactct ttgcttgttc ctgcggcctt
     1261 cactggaacg cggtcaccac gctgcgtcca gaacgccagc cccatcgttg caagcagcaa
     1321 tatacccgtg acccaaaata ccatgtggat ggagaacaca ccactaatcg ctcccccaac
     1381 gagtgggccg agcattccgc caaattgatt cgcggtctga ttcaagctga aggcgcgtcc
     1441 acggaaatta ctgtctgttg tccgcaccac gagtccgttc aatgctggga acacagcgca
     1501 gaagaagatg ccatatgtaa agcggataat cgagaaccac catatatttt gaaacggaat
     1561 ttgagcgagc gtaccgatac cgcccgcgag caggccgatc agaagaacct tctggaagcc
     1621 gatgcggtcg gcaagcttac cccatcttgc tgcgaacaga atacttgcaa cgccaacaag
     1681 cgagaacaca aatccagcta ctaatgaggc gtccttcgcg gaatgcccga tctctacaat
     1741 gtagagaggc agaacaggct caatcgtcat gaccgagaat tgggtcaata gcgacagcag
     1801 aagtacgatc ataaacggac gatttacgga tgcgatccga atagtattga cgatcgaact
     1861 gctgtccttc gttggaacga agttctcttc ttttacccag aagatgacga gcaatgttgc
     1921 aatcaaacac aagatgcctg cacatgcgaa cgtcagacgg ctgtcgaaca gcttcgataa
     1981 aatgccgccg aggagcggcc ccattattgt accggttgcg gtggcggttg ccatcatcga
     2041 caaggcatag ccgacctttt tttcaggtgt actggtgcca acaagggcaa tcgatccggg
     2101 gatgaagcct gtcagcaggc cttgcaatat acggatcgtt aatagctggt actgattcgt
     2161 aacgaaagct agcataatat aagttacgaa tagtacaatt ccggcccgga taatcattgg
     2221 cttgcgtccg tacttgtcgc caatcgctcc ccagaacgga gaagaaatgg caccagcgaa
     2281 aaatacgctg ctgaacaaaa tccctgacca cagctcaata tgatccttta caccaatttg
     2341 aatcaagaag agcggcagga atgggacgac catggaaaag cttgatgaga cgatgaatgt
     2401 accaaaccat agaatccata aatttttctt ccatgtttcc attggacttt cactcctgta
     2461 gttgttttca gcaagagagc gattccttcg gagtgtgttg ttcctagaat ctcgtttcta
     2521 tttgcctact tactttagca ataaactatt atacacgacc cgtctatgaa aagcttccaa
     2581 cgattgcata tgcaactcgc tgtatcgtat gcagtgacat gccgaatgga cagcatatcc
     2641 ttcataatgg gcataggatc gaagaactga cgacggaata gtgatcatat agaaggaata
     2701 ggttgtcttc ctatcttgta atcgtgtcgt attctactgc tgtctcccgt agacgtcttg
     2761 cggtataagc ggtatatcgg ctaagtgtcc aatcactgtc ggcagcgaaa gaagcaaaga
     2821 gagcgcccgc gtaatttgcg ggcgctctac ttcgtaatgg tatagtatac gtagcgttcg
     2881 cgaatcacac tatagactac aggcgaagtg cggctaaatc gaaagcaggc acgagacctt
     2941 ccttcgctgc gcggccaagc agtgcttcga ctgcagcata gccgtcttca cctaagtttc
     3001 tagtaaattc attcacgtac aggttaatat gggcatccgt tacttcaggc gacatctcct
     3061 gtgcatgagc taggacgtat tcacgcgatg cttccgggtg tgcccatgca tattcgactg
     3121 atgcgcgtgc ccagccggcg attgcgttca cattaagcgt gcggcgggcg attatggcac
     3181 cgagtggaat cggcaggccg gtatccgctt cccaccactt acccagatcg gcaagcattg
     3241 tgagaccgta agacggatat gtgaagcgag cttcatgaat aactagccct gcatcaatgt
     3301 ggccatctcg aacggccggc atgatctgat ggaacggcat gacgacaatc tctccgaccc
     3361 cgcctggcac attctgtgca gcccacaacc ggaacaatag ataggctgta gatcgttcac
     3421 tgggcactgc gacacgtcgg ccagacaagc tggatgggtc agctggggtc gaagccgatt
     3481 ccttcgtcaa tacaagcggt ccgcagccac ggccaagcgc tcccccacat ggcagcaggg
     3541 catactcaga cagtacccaa ggcaatgctg cgaatgaaat cttgagcaca tctaacccgt
     3601 ttccgctcgc tgcaaggtgg ttcgtgatat caatatctgc atatgttaca tctaactccg
     3661 gggcacccgg tataagtcca tgcgcccaag catggaagac aaacgtatcg ttcggacatg
     3721 gggaataggc gattttcatg attacagcac ctccactaaa actgcgctgg cagcttccaa
     3781 tgcatccagc gcttcttgaa tccgccaagc ggcacgattg cgcgggccga cggcattcga
     3841 tatcgcgcgt agctccagta cgggcagacc gaaatcctgc gccgcggttg ctacgccata
     3901 gccttccatg gcttcaacgg ctgctccagg cacacgttct gccatttggg ctgcggttgc
     3961 agctgtgcct gtcacggttg taaccgtgag cacggggccg gaacgtgctg gcagattcgc
     4021 tgcttgcagt gctgtcgcca cttgagcgac aagcccagca tcgacaggaa tgcgagcaga
     4081 gccgaagcca agctcgtcca gactggagaa tccctctggg gtctccgcac ctaaatctgc
     4141 ggcaatgatg tcgcttgcga cgaccaatga tccaatctca gcttgtccgg gaaatccccc
     4201 gccgataccg gcacagatga caagccgata gttggatgaa ccctcatttg caagcttccg
     4261 agccgtccgg gctgcggccg ctgcgacacc cacgccaccg agaatgacgt catattgagg
     4321 atgatgctga agaccgcgca ataaggcatc ccgctctgct gcgacagaag tcacaattag
     4381 aatgcggccc tctgttggct gttcggcggc ttcagctgca ctaatgacag ttgaaaccgc
     4441 tgctgaggca tccttcattt ccttcatcat gttggtcgct cctttatgat acaagacaag
     4501 cgtttcacac acaccgtcta tcgcatcgga aaaattatat atcgatttac ttccttcaaa
     4561 ttatcttctt cctcaatttc tgtaaagagg ggatttattg tgtaaagggg ataatctatg
     4621 cttgcttctt atcttatgtt tatactaaca tatcatagga tggtttatga atagaagcat
     4681 ttacgattac caagtgagct caggatcgtg aacaggtttc cgcagtggaa gcagcggttt
     4741 agcagatcaa tatcggttat gatattgttg ggcatggaat gactgatgca gatagatgga
     4801 ctcaaaagca ggcagatgat tgttcagaag gagttgatta gaagtggtct caaatcgttg
     4861 gagtgagcaa catgaagtat catctgataa ctgtgattac aagcgcgatt gtcgcttgtc
     4921 gacattaatg gagtggatgc agcgggcagg tgattcccat cttgcatcgc atgatgtatc
     4981 catggacgaa ttggtaggca gcggcatggc ttggatgctg ttgaccgtgg atttggaact
     5041 gatgagaatg ccgaagtacg gagatgtact tcagttggat acatggcata agggagcgag
     5101 aggcgttcaa tggctgcgtg attatgtggt ctacgatgca gagcatcagc aaattgctca
     5161 atcccgcacg acatgggcac ttgttgatct gaataagcgg cgtattcttc gggcatccgc
     5221 atttccttat gatgttcctg tcaataatga ggattctgtg ggggagatgc ctgagaaggt
     5281 tgccatacca gaagaatcca ctcttcgcct tgcttatacc ctccacgtaa gacagagcag
     5341 tattgatatg aacggccatt tgaataatgc cagatttgct gatatatgct tggatgcgat
     5401 gacgctagag gaattggaac gaggtgtgtc gcgcttccga attacgtacc ataaggaaat
     5461 cattctcggg gatcaagtag atgtataccg ttctactggt gaagcgatgc atgcagatga
     5521 tcgccgctgc tttattcgtg gacaagcttc ggatggcagt acgttgttcg atgctgaagt
     5581 tgtttatcga gaagaatagc tgctggatag atggtgccgg ggattgggga gcgctaacgt
     5641 tgcgctcctc ttctctgtga caatgacatt aatcgtcaga atgatcggat tacgtcggct
     5701 aattgacata attgtcgaaa aaagacatcg tcctcaaaag gatgatatga tactatattc
     5761 ctgaaattgg attttttcgc ctgggagagt gcagaaattg aaaaaaataa taacagcagt
     5821 tctagggata gccttaactt ttacattcat tacaccacat gggcaagctc acgcagatgc
     5881 aagttcatat ggggttatgg atacgaaggc gtaccgtact tacgtcccga tacgctattt
     5941 gagcgataag ctgcactatc aagtgacatg ggagcctacg agtaagcgca tagaggtggt
     6001 aagcgacgat aattatctgg agatgacatt aggtacaacg caggcatatg tcaacggaat
     6061 gaatacggag ttggaagcag ccccattccg agcagggggg acgacttatg ttccagttcg
     6121 gttcgtcagc gaagcaatga acctgtctat ggaatgggac aagaacggat cgcttgtcca
     6181 tttttggaat ggggacagtc atgttcgctt gcctattgtc tcgaagcagc ggatcaacca
     6241 aacatcgtca attgagaaga gctggcgagc attcaaggtc gggaacaagc gggtgacgac
     6301 cacgatgctg accataaatc tgctgcatcc tcatatacgt ctcggcgtag gagtgggtta
     6361 cggaggagag ggctcggtcg ataacctcaa gcatatggca aagcgtaatt atgcaatcgc
     6421 tgcgataaat gggggctact ttgatgccta ttccaattcg aaggtgaagg tcccgtatgg
     6481 ctatgtagtt agaaacggaa aaatgataca taacggctct ggcgataaac gaagtgtgct
     6541 tctgttcacg aaagataatc aagtagagat gatcccgggg ccatcgttca tagatcgatt
     6601 ccaagaaggg gatgtgtatg gagctttgca ggtagggccg cgtcttatta cagacggcaa
     6661 gattaccgtt aatctgaagg gcgaaggctt taaagatccg aaaatattga agcacagcag
     6721 catacgcagt gcggttggta taacaaagga ctacaagcta atgatcttga ctacatccag
     6781 cgctacgatt ccagagcttg ctaaagtgat gaagcaggct ggcgcttatc aggcgatgaa
     6841 tttggatggc ggagcatcaa gtggccttta ttacaatgga agatatatga cataccctgg
     6901 gcggaacatt agcaatgcgc tgctcatttt taaataaaag aagtactgaa aaacagccgc
     6961 aagttgctat attagcagat tgcggctgtt actctatcta tgaatcaatc taccttggct
     7021 ccgtatgctc tagcaaatgc aacggcttga atcatatcta ttcggacttt ggtaagttcc
     7081 agtgctttga agttcactcc gttcatctca gctccccgca aatctgcacc agccaatttg
     7141 gttttggtga gatttgtacg ggttagatcg gcatcccgta ggtcagcctt ctccagcttg
     7201 ctttcagtca ggtctgcctc catgaagcga acaccacgca agttctgcct cgttaagttc
     7261 gcatggcgca tattcgtata cgaccaatct cctccgataa tcgttatgcc atcccataat
     7321 acattggtga aatccgtccc taccattttg cattctgcaa atttggccgc gaataaattc
     7381 actcctgtga accggcaatt cgtaaatgca ctgtgcgtgt gtgtagagcc attgagcacg
     7441 gctccggtga aatcacagtc aataaattga cagcttgttg tcactgctcc atccagttgt
     7501 gcacctcgaa agcggcagga ggtaaacgtg caattgcgta gctcagactc gctccaattg
     7561 acatagctaa agtcgttgcc gtcgtactgt tcttctatat aagttgtcat aggatactcc
     7621 tttgtagatt tcatacgata tcgttcatct gttccagtag ttatcgtaac aaggaaatct
     7681 acctgtttgc aatgatgcaa atattacgag gggacaccac gaaaaaatac atttcgacat
     7741 tcttttttcg acagtcatct cgctattgtt tgtatatact ttctctatgt cttttcccat
     7801 ccatagatcg acacagaagt agcatgaaca ggtattttca acaagatcca tgaagattat
     7861 tatattttat ggagacgcat attagaaatg gttcaatttc cagattctaa gcaggatttt
     7921 acatattttt gttgaagtat tgcccatatt ggatatggaa tgatccttga atacatacag
     7981 gggtgtgaaa tgggatttaa aaactggttc acgcgaggta ttttcatagg cctcattata
     8041 ttggttattg gagctataac atcgccttct ctattatcca cacaaccaga acccactaaa
     8101 ataacgatta cccaatggga tgtaatatgg gaaaagcagc aaagtgcatg gaaggacatt
     8161 gtaaggagaa cagagggatg ggagacaatt gatcttcaat caagcgtccc cctaaagcca
     8221 caaggaagcc aatctgcatg gtatcgaatt tctctcccgc ctgtgcattg ggatcaaccc
     8281 gggttataca taagtatgtt atatggattt gaagtagatg tatactcgga tgaaggtaga
     8341 aagctgtacc actctgcacg tgattatgga tctgacgtat atcaaattct tgtgccgatc
     8401 agaccatcct ctaatagtca acatgtatat atccatacgg ctacaacggt agaacgaatt
     8461 ggaatccaaa aatcaatcat catcggcaat taccaagaaa tcattcaaga ttatgcgaat
     8521 caagggctca tagatatttt actaggtagt tcattggtgt ttatctccat tgtaatgctt
     8581 atttgcgtct tttcccttcg taatattgac gtgcccagtt ggttatctct taatatcgta
     8641 ataatggctg ttggtattat catgattacg aactctaagt ttattcatac ttatttcggc
     8701 gaatatggga aactgactgt catcttattt gacatcgcca tgcaagccct ttccccagca
     8761 ctaacttatt atttcgagca aattactggg cccggaccat tctcaattac attgaaaatc
     8821 aggaagtttc aagttgttta ctctatactc atgcttgtgt gcctgtttat aaatatatta
     8881 tctaataatc agttctatgg ttttttttac tttataaccg tcaaagtgta tgcagtccta
     8941 attgtcgggc aattatgctt gctgacgggg ctttctatcg tatacgctat ccgaaaaaat
     9001 gtggacgcga tattgtttgc aattggcttt actgtttttg ctattgtgac attaggagaa
     9061 ttagtttggt ttctgcttca ttctggccag tatgaactta ccatttggaa atggggagtt
     9121 attgccttta tcattgcctt catcatgatt atgggcagaa gaatcgttgc gacgcatgaa
     9181 caggttattc aatattccaa ggagcttgaa atgtacaacg gcaagctgca gcattccgaa
     9241 aagatgcaca tcatcagcga acttgcagcc tctgtagccc atgaggtgcg caatccgctt
     9301 caggtaacga gaggattcct tcagttgatg aagaatcact cgaatgacaa agaaaaggaa
     9361 tacgtgaagc ttgcattaac tgagcttgat cgtgcatccg aaattattac tgatttcctc
     9421 acttttgcga agccagagct cgaggatgtc gtgattctta atgttgggga ggagcttagg
     9481 cagattgagg ggatacttat gccgcttgca aatatgcagg gtggtgttat cgaattggaa
     9541 gtagagtcaa atttattgat ttacggcaac tcatccaagt tcaagcaagt ctttatcaat
     9601 ctgatcaaga atagcatcga agcactgcag gatggcggta tgatccgaat agcagggtat
     9661 gaagaaagag ggggtatcat gatctgtgtt caggatgatg gtgtagggat ggatcaggag
     9721 gagatagcac gccttggcga gccttatttt tcgaataaga cgaagggaac tgggctaggg
     9781 ttgatggtca ccttccgcat cgttgaagtt atgcagggaa gcatccattt tcacagtgag
     9841 aaggggaaag ggacagaggc gatagtgcgc tttccttctg cactggaaca gccacctatt
     9901 acgcttcata gtggtactta gacgattata caatagtgag aaggggcatt ccacaagtca
     9961 tagcctgacg agggaaagcc cctttttaga gggagattat ttaccaaacg aaacggcgaa
    10021 cgccttctgc agggagtgtc tctgctggat ttggaggtat gacgaggacg aagcgatctt
    10081 ttgtttcttc ctgagtcgtt agttcaacat ggtcaggaat cgaaatgcct agtacttctt
    10141 taatggcagc cttcggatct ttgagcaagc gctccttaaa tgaaggatct tcccaggcct
    10201 tgtgaatgat ttgatttttg aaaagttgct ccgtagttac catgtgcacc cctccgtata
    10261 tggaatgaac tacacagata atgtaacact ttgcctgttt tctgaactac tactttgtta
    10321 ccgaattcga caaccaatac gacaatccgc ccatcatcag cacttcacgc tgctgtcgaa
    10381 tatggtcggc ttcttcgaca agaatctttg ctagtgaacg gttgaactct acaagttgag
    10441 gggacgcttc cggcatgcca tccagcttgg cttgaagttt caaagcttct tgaccaaagg
    10501 aagcgaggat gtcggatacg gtaatggcat gtcgaacgag ttcctcggta agtggtttat
    10561 ctgtcggaat ctgttgaata aaacgaatcc acgccagcag acaattatag cttccatctt
    10621 gtagatctgt ctgccaatct gcccagtcat cggtcatctg caaacaaaca agcacagtat
    10681 caacggcctc gtttacatgc gggagcttat cctccatacc cgttaagaag agcgcgccgc
    10741 tactagacag cttgacgagg gctgacttgt gagcgacctt gaggcgatcc gtcataaata
    10801 catcctgctc acgctcgctt gtgacgccat gaacccactc ccatgtgtac tgcctgaagc
    10861 tgtcccataa cggggactgg ggagggaaca tctgtctata gatgtcgagc aattcgatat
    10921 agcatagatt acccaaggca agctgctcgg ccttattatc gcaatcatta tccatgacat
    10981 catcttggat aaagtaatag agcatgccga atatgcttgc aagcgccagg cggcggcaat
    11041 gcgctgtcga gagtccagtc atgtcctgca tccaataagg gaggcagtag catatataat
    11101 tatttgtgct tcgatcgtta ctgggattga atttctctat atagcgcaat cctgcgtcat
    11161 tcagcggggc tgggaatgcc tcgatgatac actcggcatc ttgaaagacc tgttcaatct
    11221 cggagcggaa cggttcatac caatgcatag tatcccttct tcctatgtga ttgatgttgc
    11281 aactctgata tgtatgatgt tcggacatga tgagaaaact ggcaggcatg tgtagcgttt
    11341 gtgagtagga tggtagcagc atgaatgcat aagagctagg tgtgagtgcg gaactgacac
    11401 agaagatgca gatgttgata ggatatcttg aataggaagt ggaaggctag gaagttgaaa
    11461 acagttacca tcagtatagt ggaagattgg ataaatcgac aagaacattg ctgactatag
    11521 gcagaagtcc aactggagaa gtctgcctac aaaaatctat ctacaaaagt ctgtctacca
    11581 aagtcacatc tcgctttgct catttcgttt ctacctcggc gctccccttg agttatcagg
    11641 gaacgggatc tcgctcgggg aaaagggacg caacctacat gaagccattc cgtattggta
    11701 tagaaataac ggtttaatct aatgcggaga cggagagatc aagaggaatg ggagaatcga
    11761 gagacgagct tcaacagatg ctgcaagcga tagaggaatg ggaacgcgag cagaaggact
    11821 tatccatatt cgagaagata ggacggctgc cattcgcgct gctggatcgc ttcactccca
    11881 aggggataca gaataagatt gctgaattgc tagatgagtt gggaggctat ctccatacag
    11941 gaggaagcta cctcgtccag aagaaaagca tattacaaaa gcttcgtgca aagtgggcag
    12001 aagaagatcc tgtttccctg gcggcctcta ctgcgcaggg gaatccactg gatctgctgg
    12061 ctgtgaagca gatgccgcta gctctgagca acacagttgc ggattcggta cgggaatcca
    12121 ataagaaggt agcatttgct caaggggcaa cgacgggatt tggcggcata tttacattag
    12181 cggtggatat acctgcggtt cttgggatcg cgcttaaggt acttcaggag acggcgatct
    12241 gctacggctt cgatccggat gatcccagag agcggctctt tattgtaaag tgtatgcagt
    12301 tcacgatgtc cgacattgtg ggcaagcagg cggtgctgca agacattggc gactacgaca
    12361 acccggatag acttcgagac tcggtgtctg aagtacaggg atggcgggag acgatggtgt
    12421 cctttaccga taattttggc tggaagaagc tgttccaatc cgtgccggtt atcggcatga
    12481 tattcggttc gtttatgaac cgttctatga ttcatgacat ggcagagaca gcgcagatgc
    12541 tataccgcaa gcgggcagtg ctggaacgtc tcaatgccct ggatgactgc tgttaagcgc
    12601 tagttgcaga tattctttct gccccttcgc accgatcctt aatcctatgg caagcggctt
    12661 aaaggggcag tggttagatg taatgaattc ggcccagcgg cagcggcctg cggcacaatt
    12721 cacgtaaagc aggccgcgga tcagagaggc caatgatgga gatcaggaga cgctctagga
    12781 catgattggc ttctgtccct ctagtgctcg aatctcgctt acattttgcg taaattctaa
    12841 cgtccccata tattcccccg actcgtcccg aacagcgaaa tagcgaaaat agacgaactt
    12901 atccttgaac gggatccaga aatcctcgac atcttttttt cgcgattatt aataaattcg
    12961 ctcatcgtaa gtctccttta tcattgagat tcattatcaa taagtcaatg catgcttaga
    13021 tgatagcaaa gaacaatacg ggacgatttg attgagatca cattttgctt tgcataattt
    13081 ctgacgcatt tccttaaacg aattgcattt ccgcacccaa tcttggaaca gtacggctta
    13141 tttgtgctgg ctaggcactt catttgtgtg tggataggtg tgttcccatt ttgtaaagaa
    13201 gagtgaggaa gcatagatgt taagtgtgta aaaatatggt ttgttaatgg caactatttc
    13261 aattactatt tatgtatgga tatacacagt gcgatgtaga aatgaagtgc atatcaagta
    13321 gaggagtgcc gtagacaggc gggcccacat gcggctgatg aagagtcagt cgatgccgac
    13381 atggccctgt gcacggtgct ggtcaaacga atatgagacg ggatgtgatg ctattcatga
    13441 agggaaggac attgctgttt agtcatgtcc gtgctcatct gccgctctat gtgacagctg
    13501 taggctgcat ggcgttagcc aatttcattt actccgtatt tcccaccttg ctagggcgat
    13561 tcactgatga gctgcagatg cgggggctga cgaaggagtc cgtgattcat tacagcttat
    13621 ggctgcttgg agttgctatc gggtatggct ccttgtttgg aattggacaa tatttgaatc
    13681 atcgcctagg acgtaagttt gaattcaaca tgagacagaa gctgtttact caatttacaa
    13741 gattaagtga gcactattat tcgaatcacg gtgtaggcaa gctgctcagc tatttcatga
    13801 atgatgttac ctcggttcga gaaacgattg ccaacggcgt gaaccagacg acgaatgcaa
    13861 cgatcctgct cctgtcggtc atcattatga tgggggtaag tggcattccg ctatatttgg
    13921 tattcgtgtg cgtgcttcca ctgcttacga ttccgctgtt tgtcatttat ttcggcccgc
    13981 gcattcgcac tcgttctcgt gcggtgcagg attcccttgc ggcgatgacg gagtcggcag
    14041 aagagcaatt cggtggcatg aaggtgacga agacattcgc agttgagcat gtggcagaag
    14101 aacgcttcgg cgcaacagtg gatcagattt gcagcaatca attagggctt gtgcggatga
    14161 catctctctt ccaagcgctc attccgttcg ctggctcact ttccctcatt atcgcaataa
    14221 cgtatggggg tgtgctgtcg atgcagggac aattatccct tggaagcttc gttatgttaa
    14281 ccctgtattt gcgcatgatt atgacacccc tacagcaaat cggcaatgtc atcaatgtga
    14341 tgctccgctc acgagcttct cttgatcgct tgaaccggct gttgaatgaa gagccggaca
    14401 tccgtgaata tgcgggtgct cagccaatct cggcggacga tgctgtgatc gagatcagga
    14461 acctgacatt tgcctatcga gaggaaagta gagaatcatt agctgatgtg aatattcaga
    14521 tatcagcagg caagacgctc ggcattgttg gcaagacggg cagcggcaag tcgacactag
    14581 tgaagctgct gcttcgcgtc tacgatcctc cgaaggggac aattcggatc ggaggccaag
    14641 acatctgtga agttacgcta gagagcctgc gtacccaaat tgggtatgtg ccgcaggatg
    14701 gattcctatt cagcacgact attcgagata atattgcatt ctataaccga aatgctgcag
    14761 acgaagcggt tgaggaggcg gcgaagcaag cggacgtatg ggacaatatt atgggatttc
    14821 ccgatcagtt ctttacgaag ctgggagagc gcggccttac cttgtccggc ggccagcgtc
    14881 aacgaacgag cttggcacgg ggaatgatta agaacgcgcc cattctcatt ttggatgata
    14941 gtgtaagtgc ggttgatgtt gtaacagaga cgacgatatt gaacaatctc cgggaagttc
    15001 gaaagggcaa gacgaacatc attatcgcac accggataag cgctgtacgc cacgctgatg
    15061 aaattattgt ccttgatcat ggcagcattg tggaacgtgg aacacatgaa gaactgatcc
    15121 aatcaggcgg ctattatgcc tcgctctata cgattcaaga ggaggggaag agaaatgcct
    15181 gaaccgacag cgaacgtgaa gggcaggaac aatcatcatc ctgcacagcc caaggagata
    15241 ggctcacgca tggcaggggc ttctcccgaa gagcgcaggc aatcgtttcg cgctatgttc
    15301 gcttatgcga agccgtatcg cttgacattt ctcgccatat ttttatgtac attccttgca
    15361 attggagcgg atttgctgca gccttatctc gtgaagatcg cgattgacga tcatgtcttg
    15421 gccgggaagc acggtgtggg cacattattt ctgattggcg gcagctattt gcttctcgcg
    15481 ctgcttagct tgctgttcac ctatattcag gcgaacctgc ttcagaaggt ggggcagggc
    15541 attgtcggcc agttgcggaa ggatctgttc agacatatat caaagcaatc gatgtcattc
    15601 ttcgatcgcc attcgatggg cagcctcgta acgaatgtgt ccagtgacac cgagacgatc
    15661 aaccagttct ttactcaagt gctgttaagc gtagtaaggg acggcatgtc gcttctcttg
    15721 atcgtggcgt ttatgttttc gctcgatgcg aagcttgcga tgttctgcct tatcttgttc
    15781 ccaattattt tggcgattgc tgtcgctttc cggaaggcgc tgcgctctgc ttatcaacgc
    15841 gcacggggtg agctgtcaag gcttatcgga tttttggcgg agaatctgtc gggtatgggc
    15901 ctcatccagg cgttccatca ggagaaggag cagacagagc gcttcacggc gcagaatcgg
    15961 aagtatttgc aagagaatct gcgcgaggtg cgcacgagca tcatgttcaa ccgctctttc
    16021 gatgtgctcg gcaatgtgtc ggtcgcattc attgtgtggc ttggcggcat ggccgtattg
    16081 gatacgtcat tggcgttcgg ggttctgtat gcctttatca attacattcg gcagtttttc
    16141 cagccgatca accatattac ccagcaatgg aacacgctcc aatccacaat cgtatctatg
    16201 gatcgcttgt ggcgcatctt ccgcattcaa cctgaagtac aggatccgaa gccagagcag
    16261 gagcataatg tagttgcctc tgaagtgcag ggccaagtcg acttcaatca tattcgcttc
    16321 gcttatgttg atgatcgcga cgtgctgcat gatctggatt tgcacattaa gccaggtgag
    16381 ttcataggca tcgtaggcac gacgggagct ggcaagagct cacttgtgaa cctgctcgcg
    16441 cgcttctatg acgtcaagcg gggaagtatt gagattgatg gggttgatat ccgccgactg
    16501 ccgcagcata cgctgcatca gattgtcgga ctagtgcagc aggatccatt tctgtattcg
    16561 ggatccattc ttgataatgt ccgcttattc caggataccg tatcgcggga agaagtaatc
    16621 tgggcctgca agtcggttgg ggcgcacggc ctgatcaagc gcttgaagca tggctatgat
    16681 acaaggctgt ctgatcgcgg gagcggtcta tcggcgggag aacggcagct gatttctttc
    16741 gctcggattc tcgtgttcca gccccgcatt ctcatcttgg atgaggcgac ggcacatttg
    16801 gattctcata ccgaacagct catccagcaa gcgcttgaag tagtctcaga gggtagaacg
    16861 acgctcgtga ttgctcaccg tttatcgacg attcagcatg cagatcgcat tattgtcatg
    16921 cggcaaggcc gcgttgcaga ggaagggacg aacgagtccc ttattgcaca gaatggatat
    16981 tatgcagagc tgatccatca ttcgcgttcg taccccagaa cagcccagca acaataatct
    17041 gctgaatacg atgcatctta tctcctgata gcagttcaga gctagaatgg gaggtaaggt
    17101 gtattttcat ttcagcttat ctactagttc tagcacccgc gactttattc tagttcccgc
    17161 caaagaagca gcacaggatg gcttctatca ccaagtttca gttctctcgc gatatccagc
    17221 atcagtatta tcctctcatt cactatttaa tccttggccg catatcatgt gccggtaccc
    17281 acgattattt tatctaaatt aagtattaga ttataattat tattgataaa tgcatctcag
    17341 tgtgctaaat taataacaca cttaataata ataattatta tttaaaacat aaaataaaaa
    17401 catgcggagg cgatattatt gagtaacccg acgaaactga caacaaatca aggcgcccca
    17461 gtagctgata atcaaaactc aaaaacagct ggacagcgcg gtccagtgtt gttggaggat
    17521 taccatctca ttgagaagct tgcgcatttc gatcgagaac gtattcctga gcgtgtcgtc
    17581 catgctcgcg gtgcaggggc gttcggtgtg tttcgtccgt atcaaagcat gtctaaatat
    17641 acaaaggcag ccttcttgca ggatccttcc attgagacga aggtattcgt gcgtttctct
    17701 acggtcatcc atggagggac atctcctgag acgcttcgcg atccacgcgg attcgctgtg
    17761 aagttctata caaccgaagg caattatgac ttagtaggca ataacctgcc tgtgttcttt
    17821 attcgggatg cgattaagtt cccggatatg gtgcactccc tgaagccggc tccacatacg
    17881 aatatccaaa caccagatca ttactgggac ttcatgtcgc tgtctcctga atcgaccaat
    17941 atgttgacat ggttattctc agacctgggt atcccggcga attatcgaga aatggacgga
    18001 tttagcgtac acgccttcaa atgggtgaat gaggaaggca aggttgtcta tgtgaaatat
    18061 acatggaaat cacttcaagg tgtgcgtagc ctgactgcag aagaagcgga gcatattcaa
    18121 gcgaaggatt tcaaccacgc tactcgtgac ttgtatgaat cgatcgaagc agaagacttc
    18181 ccagaatggg acttgtatgt gcaaatgatt gagccatcgc aaggggataa ttttgatttc
    18241 gatccgcttg atcctacgaa ggtatggccg gaagagctag tgccgatgat gaaggtagga
    18301 cggatgacat tgaacgagaa ccctgcgaac ttcttcgcaa gtgtagaaca gtctgccttc
    18361 tcgccaagcg tactggtacc tggcatcgag ccatcggaag ataagctgct gcaaggccgc
    18421 ttgttctctt atccggatac acagcgccac cgtctaggga caaactattt gcaaatacca
    18481 gtcaattgcc cgtttgccca agttcggaac catcagcgcg acggagccat gaatgtgaat
    18541 caggatccgt ctccaattaa ctatgaaccg aacagccatc ccggcgcata tgttgaagct
    18601 ggagggcaat acgcagagag cgaaatgctc cttgacggca caacgatgcg gcgtacgatt
    18661 agcaagacga atgacttcgg gcaggctggc gataagtatc gcagcttaac cccagaggag
    18721 caatcgcgat tgattgcgaa cttggtgaac gacctcaagc aggttagacc tgaggttcaa
    18781 atgcgcgcat tgtgcaactt cttccgtgcc gatgcgggct atggtgcccg aattgcggct
    18841 ggccttggga ttgacgtaag tgcgcacaca cagcatatga actcataaca tgctcttaag
    18901 taacgatgaa aacaacgata agaaaggcag ggacccccat gaatcgcaat tcgatgatct
    18961 cattcgtaca atctgacagt aagcgagaac ccgtacattt aacacagcag agagaagcgg
    19021 tcttatcgtt cgttaatcaa gccaagtccc ccgcaaccgc gattgaaatt tatattggaa
    19081 tgcgtgcgac cacgaagcgc atttcactct ctacagtata ttgcagcttg aaatattttg
    19141 ttaagaacgg tatcgtgcgt gaactgaatg aagatcacac ctcgaagcgg tatgaatgca
    19201 ttgccaaata agtccttgaa tccttgatgg atcttatcat ttacatgagg aaggatagag
    19261 gctcagatta tatctgagtc cctatccttt tttttgcgtg accataccct gatgtattcc
    19321 ttggctgctc ccaattagat tgcaaaaaga ggctctcatt ttttggatct ggggcatctg
    19381 atgatagcgc tcgaagaccg gcaatatggt atattaagga gagaaaagcg tttcgcttgg
    19441 gtcgcacatg gtcaatgatt cgaaggagat atgggtattg atacttaatc cagagcagct
    19501 tcagtcgcta atagagcaga ttgagcttgt tctgctgcct gcagcagaca ttcgcagtct
    19561 gaatggggac gaccccgttc aagtgtccaa tacaccggtg gattgggagg ttattggcgc
    19621 agggaattat gcggtcgtct tcagccataa gcaatatgcc tctgttgccg taaaagtgta
    19681 tgcagcaggt aggaagggtt tggacgacga agcggaagta tatcgacgtc ttggcaagca
    19741 tcctgcctat tcggaatgtt attacgtcgg gcaaggatat ttgatattga agcggctacc
    19801 tggggtaacg ctgtatcact gcctccggca cgggatatcg ataccacaat cggtattgga
    19861 cgatattgat gaagcgctgg agtatgcatc cgcacgaggg ttgaccccaa gagatattca
    19921 tgggaaaaat gtcaccaatg attgtggcaa agggtatgtc gtggatgtat ccgattttct
    19981 gatcccgcag cctgaccgca tgtggggaga cttcaagcgg gcatatcggt tgttgtacaa
    20041 accgttgggt ctgaagtggg gagtgccggt tccggggtgg ctgcttgaac tgctgcgcaa
    20101 aagctaccag atttaccgta gacgcgcggc tgcgacgggc tgcgataaga actgactatg
    20161 cgagcgggaa ggaaaataca tgggtagtag aaagtcatag tactaggggt ttcatatgta
    20221 gcaatgtcca tacacggtgt cag
//
