LOCUS       NZ_JAPDMW010000003     17542 bp    DNA     linear   CON 23-JAN-2024
DEFINITION  Paenibacillus alvei strain LF-11/2021
            NODE_3_length_632384_cov_46.373152, whole genome shotgun sequence.
ACCESSION   NZ_JAPDMW010000003
VERSION     NZ_JAPDMW010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus alvei
  ORGANISM  Paenibacillus alvei
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 632384)
  AUTHORS   Fallico,L.
  TITLE     Analysis of the Paenibacillus alvei's inhibition ability against
            multidrug resistant bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 632384)
  AUTHORS   Fallico,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2022) U.O.C. Microbiologia, Ospedale San Bortolo
            AULSS8 BERICA, Viale F. Rodolfi, 37, Vicenza, Vicenza 36100, Italy
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.14.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 71.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/23/2024 02:12:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,998
            CDSs (total)                      :: 5,902
            Genes (coding)                    :: 5,824
            CDSs (with protein)               :: 5,824
            Genes (RNA)                       :: 96
            rRNAs                             :: 9, 1, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9 (5S)
            partial rRNAs                     :: 1, 8 (16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 32 of 78
            Pseudo Genes (incomplete)         :: 65 of 78
            Pseudo Genes (internal stop)      :: 14 of 78
            Pseudo Genes (multiple problems)  :: 27 of 78
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:37:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 434433
            Orig. end                         :: 451975
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAPDMW010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17542
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     cand_cluster    1..17542
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17542
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:12542](+)"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12542
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     misc_feature    137..150
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     misc_feature    complement(239..250)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.59"
                     /tool="antismash"
     gene            333..1085
                     /locus_tag="OF778_RS08250"
     CDS             333..1085
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005545240.1"
                     /locus_tag="OF778_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_268624237.1"
                     /transl_table=11
                     /translation="MIRIQGLHKTFGKHVVLHHVDLTVEEGQVVAIIGPSGSGKSTLLR
                     CLNFLETPQAGSIALGDYELNMSKATKRDILYLRRNTAMVFQQFHLLKYKTALENVMEG
                     LVTVQGMKTQQAHDIASSYLDRVGLQDRKDYYPRELSGGQQQRVGIARALALQPKVILL
                     DEPTSALDPEMVGEVLAVIRAAAREGRTMIIVSHEMGFVQEIADKVIFFDQGSVVEEGT
                     PKEIFRAAKHERTKQFLSRVSRPADYVI"
     gene            1122..1910
                     /locus_tag="OF778_RS08255"
     CDS             1122..1910
                     /EC_number="1.13.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005545242.1"
                     /locus_tag="OF778_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III extradiol ring-cleavage dioxygenase"
                     /protein_id="WP_268624238.1"
                     /transl_table=11
                     /translation="MSTATTTSAPVLFLAHGSPLIAIQENDYTRFLAQFAKDLPVKPTA
                     FVVFTAHWEVESSTRITYSDDTYHTIHDFGPWWMDEMFAVQYPAKGNKELALRIHNLLS
                     QHDIPSELDAERGLDHGTWSLLKQFDPNASTPVVQLSVNPNLSAKDQFLIGRAIRELQH
                     EGVLIIGSGVTVHNLSLHSDVTESWALEFDDWLIDNIERKNYDALFNYAEDAPYAKLAV
                     PTPEHFVPILIALGSGEPEREAKVIYRDYAGLLSYLCYQF"
     gene            1999..2310
                     /locus_tag="OF778_RS08260"
     CDS             1999..2310
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OF778_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268624239.1"
                     /transl_table=11
                     /translation="MADWSRVLPFTPESAELIPEAIGIFVFLTKQLDNRMYKVIYVEQT
                     ANLRARYLDYVNGEEPYLLEHAVNYRYVVEPKQEARDAEEKLVLTEGAPTLNLLKSTP"
     gene            complement(2646..3554)
                     /locus_tag="OF778_RS08265"
     CDS             complement(2646..3554)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OF778_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268624240.1"
                     /transl_table=11
                     /translation="MYQKIFKVAVPVLTASSLFVVTPTSSFATSNPHVAVNSVAPASTF
                     ESHNPWENGKLSEIAWESDHPDTIDMNLKYDDDAKGLFEKLKALNAAATEQSAARIAEE
                     NALLNTIRTLNPNKISEMSSLVLDSKSEYRTSFSLVAWYISSLDLPFAARAMLHSLDDK
                     PTDVWYEAGSSLSNGWSWTAAYTTFSIPIAKAISKANSEGKKYVGGDTSIATSAGNAGL
                     DFYLALGKVTISWSAEKQSGGNWKVYIHTYDKYDFTEVKVPNSFPDNIIAIANNQAADA
                     QRVGAIVPYMTHIFNQQDYTP"
     misc_feature    complement(4662..4678)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.77"
                     /tool="antismash"
     gene            5001..6146
                     /locus_tag="OF778_RS08270"
     CDS             5001..6146
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012885.4"
                     /locus_tag="OF778_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_268624241.1"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-73, bitscore:
                     243.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNILIEDSTLREGEQTPGVAFSESQKRSILEGLAKANIKYAEVG
                     IPVMGSVEFKAIQALAKDPHLPKLIGWNRGVKSDVERTFEAGLTALHIGLPSSDVHIKE
                     KFKRDYNWVIETAVELIEFAKSQGATFISVSAEDMGRANMDFLKKYVKAVEKAGATRMR
                     LSDTVGCLTPSKVKEIVTTLTREVSNLNFQLHMHNDFNLALANVISGLEAGAKQVHVTI
                     NGLGDRAGIAALHQVVTALEVLTDYTTDVNLLEIYNLSKLVEQYTNLHISHNEPVVGEL
                     VFAHESGIHVDGMLKVKHSFEAFAPELVGRSNTFIIGKHTGSRAIQHVLQEQGLHVSRE
                     EAQEIIPFVREFSTMTKSSIEPELLSLFARSILKKNVAVEV"
     gene            6244..7524
                     /locus_tag="OF778_RS08275"
     CDS             6244..7524
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017754686.1"
                     /locus_tag="OF778_RS08275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-isopropylmalate dehydratase large subunit"
                     /protein_id="WP_268624242.1"
                     /transl_table=11
                     /translation="MGLTAIEKIISNHAGKQVHAGDLVIASVDAVMAQDGNAPLAIKIL
                     KEELGASQTFDHKKVILVIDHCGPSPNEGASNLQQMMRDFSKEYGATLYDAGEGISHVL
                     LPEQGHAQPGKLIVGSDSHSVTYGAVNCFGTGMGSTDIATAMYTGKVWMRVPETIKVAL
                     TGRLPDSVSAKDLALHLVRLIGVSGATYKCVEISGDGLTTLNMDNRFTICNMAIEMGAK
                     CTLMPVDDICRQYLEERNDEVPDMVWSDPDCSYDGIFEVDLSKIEPLVALPHDLTKIVS
                     IRSTIEQNINMAFIGTCTNSRISDLEEAANVLRSHKINPGVRLIITPGSRSTYLEAVRK
                     GYVDVFITAGAIVTPPGCGPCVGTHLGIPGDSDVVISTANRNFKGRMGNPQSSIILASP
                     ATVAASAILGKVGSAEEVSRELTRQSS"
     gene            7499..7999
                     /locus_tag="OF778_RS08280"
     CDS             7499..7999
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02087.1"
                     /locus_tag="OF778_RS08280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-isopropylmalate dehydratase"
                     /protein_id="WP_268624243.1"
                     /transl_table=11
                     /translation="MSLQGKVHKFGDNINTDDIIAGKYKHKTMDVEQLSNHIMENIYPN
                     FRQVITQGDYIVAGENFGCGSSREQAPQIIKHVGISAVIAKSFARIFFRNSINIGLLVI
                     TCDTDQIESGDMILHLPNSQQIQIVNKGITIAAPNVPQEIMGIVHSGGLLAYAKSGGLE
                     QLT"
     gene            7996..9027
                     /locus_tag="OF778_RS08285"
     CDS             7996..9027
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012407.4"
                     /locus_tag="OF778_RS08285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isocitrate/isopropylmalate family dehydrogenase"
                     /protein_id="WP_268624244.1"
                     /transl_table=11
                     /translation="MKPLNIVLIEGDGIGPEITSSAVKVLLATGIPIDFEKRLAGLKSL
                     ETNGQLVPDDTIQAIGQFGYALKGPFTTPSGGTQRSPNWVIRQKLKLFSCVRPLKDLSK
                     GIDIVIIRENTEDLYGAIEWASSPDVMQAVKIATKDGCERISKFAMNFCRKERRKKITI
                     VHKANNLKLTEGLFLQQAKSIAVVYPEILVDDMLVDTAAYRLVTNPETFDVILTSNTFG
                     DILSSAGAALVGGLGIAPSVSYGKDAVVAEATHGSAPDIAGKGIANPIGIISASAMLLK
                     ATGLVPQAELIDQAINWACKNNVTTPDMGGTASTSEVADEITKYIKSRGGLFAKNNDAS
                     SIV"
     gene            8984..9922
                     /gene="aepX"
                     /locus_tag="OF778_RS08290"
     CDS             8984..9922
                     /EC_number="5.4.2.9"
                     /GO_function="GO:0050188 - phosphoenolpyruvate mutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="aepX"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003474429.1"
                     /locus_tag="OF778_RS08290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoenolpyruvate mutase"
                     /protein_id="WP_268624245.1"
                     /sec_met_domain="phosphonates (E-value: 1.2e-106, bitscore:
                     350.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 5.3e-115,
                     bitscore: 378.1, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.4e-61, bitscore:
                     202.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVCLRKTTMLRQLFSSPGCIKVIGVSDGITAKMGDQAGFDALWAS
                     GLAISASHCVPDASILTMSEFLSAASLIHKATKLPVIADCDTGFGEVNNVVRMVREYER
                     SGIAAVCIEDKEFPKRNSFLENHRLANKHEFCGKIMAAKDAQLDPDFMIIARLESLIAN
                     AGMNDALDRAFAYSEAGADAILVHSKSTEPTEIKEFASIWKMKGGAKPLIVVPTTYYNI
                     KCDELYNDGFKMVIYANQALRASVMATKEAFEEILRTGSTASIEGKISSVKEIFSLIGT
                     DELNRIESWFHEVIKPQLDNKVLASNHTAIK"
     gene            9953..10708
                     /locus_tag="OF778_RS08295"
     CDS             9953..10708
                     /GO_function="GO:0046353 - aminoglycoside
                     3-N-acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003291159.1"
                     /locus_tag="OF778_RS08295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAC(3) family N-acetyltransferase"
                     /protein_id="WP_268624246.1"
                     /transl_table=11
                     /translation="MLNSQQITEKLLHALNPLISEGEDMLILHSALSKLGFERGAPYVD
                     GLMEFLQALIDRGITVVLPSFTFSFTKRKRFCLNHDPSETGILADLARKHLQFSRSKNP
                     MFSFSVKGPKEDEILLTRQDSGYGIGTAVSRLAAADTTVVMLGANWNCCTIIHAIEENL
                     QVPYREYINWSYEIDFGDGAATRPFNLFVRKLDSNSILRFDRIRGELLQTGALRQSTLN
                     GLYIEAANSGDIAEISEKRMRLDPYFFIE"
     gene            10719..12542
                     /locus_tag="OF778_RS08300"
     CDS             10719..12542
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (311-595). E-value:
                     3.1e-35. Score: 113.9. Matches aSDomain:
                     nrpspksdomains_OF778_RS08300_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060087.1"
                     /locus_tag="OF778_RS08300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_268624247.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.8e-09, bitscore:
                     31.3, seeds: 297, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.1e-34, bitscore:
                     113.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTAMILCAGRGIRLTPFTNNKPKPLVEVNGISILENSIQQLIN
                     AGYQNLSIVVGYKGDMIKEIVSKYSSQLDIHIIENNEWSTSNNIMSLWKARNELQGDIT
                     LLEGDVFYDESVLKQLNDMPLGANYLVVSPLTSFMDGMYVTEEAGKISGFYNTSKKTHQ
                     HGKEPLKSVNICRLSTNICQYLVESIQKEVAAGNMHRFYDDLFEDAFRLGYEFRVVKVD
                     TKSWFEVDNPYDLSLCEFQHSRDPYQRLKQQHGGYWRHPITDFALIYNLHFPPKTLKEK
                     IKDRFDEIILNYPASSVPIIRHLSYFLGVNDDKLAIANGVSEIIKLLPRFIKGNIVLVE
                     PSFNEYANCFTDERITTFQLKEKDDFQLNIYDLIECILHNDAQAVILETPNNPTGRLVK
                     KEDIIKLYEATEQHNILVVLDESFIDFSCRETTEQLLHDLHLYPRILLFRSMSKTFGIG
                     GLRIGYAVSSNLYMIKELRSELPIWNINGFAEEFLLNLPPYREEYFRSCKVVRRETDNL
                     LDALRQIDGIKAFDTEANFIFCKIQNKLFTAEQLAHKLVRKYGVYIKECSGKKLPDSEY
                     FFRVSSRTDSENEQLIHALSTIFEREYDYTT"
     aSDomain        11652..12503
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_OF778_RS08300_Aminotran_1_2.1"
                     /evalue="3.10E-35"
                     /label="OF778_RS08300_Aminotran_1_2.1"
                     /locus_tag="OF778_RS08300"
                     /protein_end="595"
                     /protein_start="311"
                     /score="113.9"
                     /tool="antismash"
                     /translation="DDKLAIANGVSEIIKLLPRFIKGNIVLVEPSFNEYANCFTDERIT
                     TFQLKEKDDFQLNIYDLIECILHNDAQAVILETPNNPTGRLVKKEDIIKLYEATEQHNI
                     LVVLDESFIDFSCRETTEQLLHDLHLYPRILLFRSMSKTFGIGGLRIGYAVSSNLYMIK
                     ELRSELPIWNINGFAEEFLLNLPPYREEYFRSCKVVRRETDNLLDALRQIDGIKAFDTE
                     ANFIFCKIQNKLFTAEQLAHKLVRKYGVYIKECSGKKLPDSEYFFRVSSRTDSENEQLI
                     HAL"
     gene            12560..13720
                     /locus_tag="OF778_RS08305"
     CDS             12560..13720
                     /EC_number="1.1.1.267"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0030604 - 1-deoxy-D-xylulose-5-phosphate
                     reductoisomerase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070402 - NADPH binding [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000598971.1"
                     /locus_tag="OF778_RS08305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /protein_id="WP_268624248.1"
                     /transl_table=11
                     /translation="MKRNISILGSTGSIGTSTLEVVKQHLDRFRVIGLAANTQIDTLIQ
                     QIQTFKPKIVSVATKEGAEKVRDAIDPEIEVCVGSEGLIEVATYLEVDFVMNALVGMNG
                     LLPTIEALKAKKDIGIANKESLVAAGHLIKKLAFENECMLYPIDSEHSAIFQCLIGEDR
                     SAIDKLIITASGGAFRDKSRFEMERLSVTDALNHPNWKMGAKITIDCATLMNKGFEVIE
                     AHWLFDVPYEKIEVLIHPESIVHSMVEFHDGSIIAQMGVPDMFVPIQYALSYPDRLDNR
                     INRLNLAEIGKLHFYEPDYIRFPCLEVAIQAAREGGSTTTVLNAANEVANEHFRQGMIN
                     FLDIEKIIIKTLEKHEKVKFPSLDEVLGIDEWARSFSSQVATCYVL"
     gene            13755..15071
                     /locus_tag="OF778_RS08310"
     CDS             13755..15071
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OF778_RS08310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268624249.1"
                     /transl_table=11
                     /translation="MEENEYKLTVCGCGPAGVSPLIYMEEYDLLEPLLKEGVCLIDKSN
                     SVGSGNIKNYKITANSLGKVFTEIFTNPQSPLLKYLTDKESCKELSHFKDDPPNLPLVG
                     KLMDDIGDYLSEKIKSFAQSKVLLNTTVTQIHTRLDGRYDIVFNYGDSKDSSAKLTTEH
                     LLFNLGGLQEFPPFISQKTASSGHVWLSSDFIMGKWDHDLLSLLQRSTNTLNIAVIGAS
                     HSAFSILYRLKNHFNLIPGSQIDVNILHKSPLRLFYNSIEEASQAGYHFDCKTDVCSHS
                     GRVNRFSGLRYDSFQLARDVLDGKYNNVRLSPVSKSGRSDEHEYINRADIIIVSTGYKK
                     NRVQIFDKDGSLLSLAMDSNGVITNNYCNPILQNGRALQNFYTYGLGAGQRVNAENGGE
                     TSYTGRIDGIWFYQHEVTKRIVPIITSKVKQLLESKRRR"
     gene            15077..16435
                     /locus_tag="OF778_RS08315"
     CDS             15077..16435
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF021616.4"
                     /locus_tag="OF778_RS08315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_268624250.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.7e-31,
                     bitscore: 103.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFHASIVIPTFNRSKLLEYTIKSLLKQNASPYMYEIIIVDDGSTD
                     ETQQMVQKYMENNHIVYFFQDKKGYRVSSARNTGINNARGNTIIFLDSGMLVGSNFVYE
                     HCRAHDSRATDTVIIGYIHGFQANEEDHTFIELVDFNDIDHTLQRIKESGLYQDLREAG
                     FTFFQDHIQNSDAPWYYFWTGNVSVQKNVLQKHGGFNEAYNTYGMEDQELGFLLYDNGL
                     DFELHRAAEAIHYPHETFAKADKKASGEKNAFKFHKKYNRLITEQFYLSLNRKFNEELY
                     DLKQKGDTRINYNTSYFDKFFKSSFCENNGRAILFGGHNGALLNFLQFGYVLEYHQPYF
                     EELKRNHLDRSVYQLMGGITPFPDKYFEYVFITDYWNCVDTKWLPKIMKEAVRIANVVH
                     IITEIIYNNSYVFSPQKNKQLDLLEALRSYNLSPHLCQKQNGELEMTYLELRS"
     gene            16443..17471
                     /locus_tag="OF778_RS08320"
     CDS             16443..17471
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="OF778_RS08320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_268624251.1"
                     /transl_table=11
                     /translation="MSIVSVNNLYRHYKVLNRRAGFIGNISNLFSRDYRTVKAVDGISM
                     EFQEGEIVAFVGPNGAGKSTTIKMMTGVLEPTSGNILVNGIIPYKNRVKNAENIGVVFG
                     QRCQLWWDLPVIESFKLLKLIYKIDKNDYEANMSMFDEVLNLKSLYTTPVRFLSLGQRM
                     LCDIAAAFLHNPKVIFLDEPTIGLDISVKSKIREFILRLNVEKKTTVFLTTHDIGDIEA
                     LCERIILIDKGMIIYDGSIQKIINLYGAYRTLKIEFLGEDETIGIRVIAELEKGLENFN
                     RIAVDQQESGWLQLTFNQENIELVDIMNVILKKFKVKDIKLEEVKTESIIKKVYERELL
                     HA"
ORIGIN
        1 tgtcgataag ggtggcattg aagccggata ttctatgggt atgacaacaa cgcaggttct
       61 gcgccgcatc attttgcccg aagcgctcgt cgttgcactg ccaaccctcg gcaattctct
      121 aatcgggctg attaagggca cttcacttgc ctttgtatgc tcggttgtgg agatgacagc
      181 cgctggcaag ctgatggctt cccgcaattt ccgcttcttc gaagtgtatg tgtcgcttgc
      241 gatcatttac tggctcgtga caattatgat agagcgccta attgcgcgtt gggaaaagcg
      301 gctgaaggtc aacgagagga gggtggtagc tgatgatccg aatccagggc ttacacaaaa
      361 cattcggtaa acatgtcgtg ctgcaccatg tggatctgac ggttgaggaa ggtcaggttg
      421 tcgccatcat cggcccttcg ggctcaggca agtctacact gcttcgctgc ctgaacttcc
      481 tggagacacc gcaagcgggc tcaatcgcac tgggcgacta tgagcttaat atgtccaagg
      541 cgacgaagcg cgatattctg tacttgcgcc gcaataccgc aatggtattt cagcagttcc
      601 atttactgaa gtacaagaca gctcttgaaa atgttatgga aggtctcgtg acggtacaag
      661 gaatgaagac acagcaagcc catgacatcg caagcagcta cttggatcga gtcggacttc
      721 aggatcggaa agactactac cctcgcgagc tatcaggcgg tcagcagcag cgtgtgggca
      781 ttgcccgggc actcgccctt caaccgaagg taattctgct cgatgagcca acctctgcac
      841 ttgatccgga gatggtcggc gaagtgcttg ccgttattcg ggcagctgca agggaaggac
      901 ggacgatgat tatcgtgtct catgagatgg ggtttgttca ggaaattgca gataaagtga
      961 tcttcttcga tcagggttcg gtcgtggaag aaggaacacc gaaagaaatc ttcagagctg
     1021 cgaagcacga gcggacgaag cagttcctct cccgtgtcag ccgacctgct gattatgtga
     1081 tttaacgcta agagatatga ataaagaaag gtgtgtgaat catgtccacc gctacaacga
     1141 cttcggcgcc tgtattattt cttgcacatg gatcgccgct catcgccatt caggagaatg
     1201 actatactcg ctttttagcc caatttgcca aggatttgcc tgtgaagcca actgccttcg
     1261 tcgtatttac tgcgcattgg gaggtggaat ccagcacgcg aataacgtac tcggacgata
     1321 cctaccacac cattcatgac ttcggtccgt ggtggatgga tgagatgttc gccgtacaat
     1381 atccagctaa gggaaataaa gagctagctc tccgtatcca caatctattg agccaacacg
     1441 atatcccgag tgagctggat gccgaacgag ggcttgatca tggcacatgg tccttgctca
     1501 agcagtttga tccgaatgcc tccactcctg tcgtacagtt atcagtgaat ccgaatctga
     1561 gcgccaagga tcaattcttg attggccgtg caattcggga gctgcagcat gaaggtgtgc
     1621 tcataatcgg aagcggcgtg accgttcaca atctgagctt gcatagcgac gtaactgaat
     1681 catgggcgct ggaattcgac gattggctga ttgacaacat tgaacgcaag aactatgatg
     1741 ctctattcaa ctatgccgaa gacgctccct acgcgaagct tgctgtgcct acaccggagc
     1801 atttcgttcc gatcctgatc gcactaggaa gcggagaacc agaacgtgag gctaaggtca
     1861 tctaccgaga ttatgcaggt ctgcttagct atttgtgcta tcaattctga tctaggcctg
     1921 agggtatctg cggacggtct tgtttacacg ccatattggc catattgaat aatttaaaac
     1981 gaagtggagg cgatgaagat ggcggattgg tcgcgagtac tgccatttac ccctgaatca
     2041 gcggagctta tccctgaagc gatcggaatc ttcgtgttcc tgacgaagca gctggacaat
     2101 cggatgtaca aagtcatcta tgtggaacag actgcgaatt tgcgtgcacg ctatctcgat
     2161 tacgtgaatg gagaagagcc gtatctgctt gaacatgccg taaactatcg atacgttgtc
     2221 gagcccaagc aagaagcgcg tgatgcggaa gagaagcttg ttctgacgga aggggctcct
     2281 accttaaacc tgctaaagag cacgccttga acaagaagta ttagagctat cggcatcgtc
     2341 accagaatct aaacatatgc ggagaattgg attatttcgt cgcgaggatg atgctgtagt
     2401 gcgtaatcga tttgcttggg aatgtagacg aacattatat gtaaagttca caccaaacgt
     2461 ttggatcttg aaaaaattgt cgctcacggc tgaatttccc caagcacggc aatcaagggg
     2521 ctggattggt acacaaaatc attgattttg tgcacacata tttaatctat aaatggacac
     2581 taataatagg gagtccaaat aaaacagtcc tattcgatta atgaatagga ctgttttatt
     2641 tggatttaag gagtataatc ttgttgatta aaaatatgtg tcatatacgg tacgatcgca
     2701 cctactcttt gagcatcggc agcttggtta ttagcaattg cgataatgtt atcagggaaa
     2761 ctattaggga ctttaacttc agtgaaatca tacttatcat aggtatgaat ataaaccttc
     2821 cagttccccc cactttgctt ttcggcagac catgatatgg ttactttccc taatgctaaa
     2881 taaaaatcca atccagcgtt accagcacta gtagctatgc ttgtatcgcc tcctacgtat
     2941 ttcttaccct cagaatttgc ttttgatatt gctttagcga taggaattga gaatgtagta
     3001 tatgcagcag tccaagacca accgtttgaa aggctgctac ctgcttcgta ccagacatct
     3061 gtaggcttgt catcaagcga atgaagcata gccctagctg caaatggaag atccaaggag
     3121 gatatatacc aagcaacaag cgagaaactt gtacgatatt ctgacttaga atcaagaacc
     3181 aacgatgaca tttcagaaat cttatttgga ttaagtgttc taatagtgtt taataatgcg
     3241 ttttcctcag caattcgggc ggccgattgt tctgtagctg cagcatttaa tgcctttaat
     3301 ttttcaaaaa gacctttggc atcatcatca tattttaagt tcatatcaat ggtatcagga
     3361 tgatcacttt cccaagctat ctcggaaagt tttccatttt cccatggatt atgactttcg
     3421 aatgttgaag caggtgccac tgaattaaca gcaacatggg gattagaagt tgcaaatgat
     3481 gaagttggcg taacaacaaa caaactactt gctgttaata ccggtactgc cactttaaaa
     3541 attttttggt acatattaac aaacacctct attttcgata ttatgaaatc actatcacag
     3601 taggaggatg aattttgcat atgaagaaaa ttttgaagat tttaggagtg gttcttcttt
     3661 ttttgcttgc attgtttttc ataggcagat ttctcataat gattttgctt ttgttgggag
     3721 catttcgtca gaactgaaaa actattgatg ggtgattttt aggggtatct atcttaaaat
     3781 agtcatttac tcagaaatca cctcctaata tttaaaatgg aatcaacgat agattagcat
     3841 ttttggttaa atattacaac gttaaatgta gtaatatcga aatatatcaa tatatttttc
     3901 ggtggggtta cggcgaaatc ttctgtaagc gaggtgataa gccgtgactt cttgttagat
     3961 atcctagata cggttgagaa gtcgggcagt aaaaaattgg tatgtacgct ttttatcaag
     4021 cattgaaagc gacgtaaaac aagcggataa catcgagaat aaggttggct ccctgattgt
     4081 ttatttttcg ctaaaaatat gagttatgtc ctcggaacac attctataat gccttcgcgc
     4141 tgcgttgaaa gtgttcggca actgtagctt gattatcttc cggaattaac aaaaagccaa
     4201 aggtacagcc acagtacaga aatttgttaa gctcttcaac ataaataaac tctataatgt
     4261 ccggctttat tgactttgca aaattgataa aacttcgtta gaacgattcc ctacactccc
     4321 cacagtaaca ccgtagttca tgttgtcggc gaaacgacac aattgcgacc agctatgtcc
     4381 gcagctcctg aacggagaga aacaaatcct ccatcatata tactcgttcc aggtgttcag
     4441 cttcagtatg caacctctaa caacaaatag tcgtattaat caagcttggt tccaaatgat
     4501 aaataaaaaa taaatattac tacttacaga atatgagtgg agatgtaaaa aaccaaaaaa
     4561 gggtatatca gtaaattatc cataatttcc ttgactttat tattatgttc ttgtaaattt
     4621 gattttagtt aatacgcttt tatttctacg caacctacga actttaaaaa aactacaagt
     4681 tctattgaca gaagcgaaag ccctctcgtt tatcaatcct atctaacgcc tacttccaaa
     4741 acgtattttt gcctgaaaca gttgtataac taaaggaggg aacccatcac tatcctgaaa
     4801 aaataaagtt taagcattta accttctttc tagagccaaa gtattaattg gcaaccattg
     4861 ctcttcccta ccacttatcc catccacctt gaaaatcaat aaataccaat cttggatcgc
     4921 tggaattcgc cctttttata tttatataat tgattggatt ttgacttcta cattaattta
     4981 tcgtgaagag gtgcaaaaaa atgacaaata tcttgattga agatagtact ttgcgtgaag
     5041 gtgaacaaac gccgggtgtc gctttttcgg agagtcaaaa aagaagtatc cttgaaggat
     5101 tggcgaaggc aaacattaaa tacgctgaag ttggcatccc tgtgatgggc tcagttgaat
     5161 tcaaagccat acaggctctt gcgaaagatc ctcatctccc taaacttatt ggttggaatc
     5221 gaggagtaaa aagtgatgtt gaaaggacat ttgaggctgg tcttactgca ttgcatattg
     5281 gtctcccttc ttcagatgtt cacatcaaag aaaagtttaa aagggactac aattgggtta
     5341 tagaaacagc tgttgaactg attgaatttg caaagtcgca aggtgccact tttatttctg
     5401 tcagtgcaga ggatatgggt cgcgctaata tggatttttt gaagaaatat gtcaaagccg
     5461 tagaaaaagc cggtgctact cgtatgagat tatccgatac cgtgggatgt ctgacaccaa
     5521 gcaaagtgaa ggaaattgta accaccctga cacgcgaagt aagtaatctg aatttccaac
     5581 ttcatatgca taatgatttt aacctcgcac tagcaaatgt tatatctggg ttagaagccg
     5641 gagccaaaca agtccatgtt accatcaatg gtttagggga tcgtgcaggc attgctgcat
     5701 tacaccaggt tgtaacagca ctagaagtcc tcactgatta cacaaccgat gttaatttac
     5761 tggagattta caacctctca aaactcgttg aacaatatac taatctgcat atttctcaca
     5821 atgaacctgt agtcggtgaa ttagtttttg cacacgaatc aggcatccat gtagacggaa
     5881 tgttaaaagt aaagcatagc ttcgaagctt ttgcccccga acttgtagga cgaagcaata
     5941 catttataat cggcaagcat acgggttccc gtgccattca acatgtacta caagaacaag
     6001 gcttgcatgt atcgagagag gaagcccaag agattattcc ttttgttagg gaattttcta
     6061 caatgactaa atcaagcatc gaaccagaat tgctttcatt atttgcaaga tctattttga
     6121 aaaaaaatgt tgccgttgaa gtataacggt taaatccgac ttgataatgc aattcacttt
     6181 catgaagtgt cttagcgtga atgatagcgt aaggcataag ggagtaagga ggagaaagct
     6241 gtaatgggat tgactgcaat cgaaaagatt atttcaaatc atgcaggtaa gcaagtccat
     6301 gctggagatc ttgtaattgc ttctgttgat gcggtaatgg ctcaagatgg gaacgcaccg
     6361 ctagcaatta agatattgaa agaggagtta ggcgctagtc agacatttga tcataaaaaa
     6421 gtaattcttg tcatcgatca ttgtggccct agtcctaatg aaggggcttc caacttacag
     6481 caaatgatgc gggatttttc gaaagaatac ggtgctactc tttatgatgc tggagaaggg
     6541 atttcccatg tcttactgcc tgaacaaggt catgctcagc caggaaaatt aatagtaggt
     6601 tctgattccc attcggtaac ttatggcgca gtaaattgtt ttggaacagg gatgggttca
     6661 accgacattg caacagctat gtatacagga aaagtatgga tgagggtgcc cgaaacgatt
     6721 aaagtggctt taacgggccg attacctgac tccgtatccg ctaaagatct agcattgcat
     6781 ttggtacgtt taatcggagt aagcggtgct acatacaaat gcgtcgaaat atccggagat
     6841 ggattaacga ctcttaatat ggataatagg tttacgatat gtaatatggc gatcgagatg
     6901 ggagcaaaat gcacactaat gcccgtcgat gatatttgtc gacagtactt agaagaaaga
     6961 aacgatgaag tccccgatat ggtatggtca gatccagact gttcttatga tggaattttc
     7021 gaagtggatc tttcaaaaat tgaacctttg gtcgcattgc cacatgattt gacaaaaatt
     7081 gtttcaattc gatcaaccat agaacagaat attaacatgg catttatcgg aacttgtaca
     7141 aacagtagaa tttcagacct agaagaagca gccaatgtat taagaagcca caaaattaat
     7201 cctggtgtac gcttaatcat tacccctggt tcaagatcga cttacttgga agccgtccga
     7261 aaaggctatg tggacgtttt tattacagca ggggccatcg tcacaccgcc tggttgcgga
     7321 ccttgtgtcg gtacccattt aggcattcca ggtgactcag atgttgttat ttcaactgca
     7381 aatcgcaact ttaaaggacg catgggcaat cctcagtcct caattatttt ggcttcacca
     7441 gcaacagtag cggcttcggc cattcttgga aaagtcggat cggcggagga ggtatctcgt
     7501 gagcttacaa ggcaaagttc ataagttcgg cgataacatt aatacagatg atatcatcgc
     7561 cggtaaatat aagcacaaaa cgatggatgt tgagcaatta agcaaccaca tcatggagaa
     7621 tatttatccc aattttcgac aggtcatcac gcaaggtgac tatatagtgg ctggggaaaa
     7681 tttcgggtgt ggttcttcaa gagaacaggc accacaaatt attaaacacg tagggatctc
     7741 cgcagtaatc gcgaagtctt tcgcgcggat tttttttaga aactcgatta acatagggtt
     7801 attggtcatt acatgtgata cagaccagat tgaatcaggt gacatgatac ttcatctacc
     7861 caactctcaa caaatacaaa tcgtaaacaa aggaattacg attgctgctc caaatgtacc
     7921 tcaagaaatc atgggaattg tccattcagg cggcttgctc gcctacgcga aatcaggagg
     7981 cttagaacaa ttaacatgaa acccctcaac attgtactaa tagaaggcga cggcattggc
     8041 cctgaaatta catcctcagc agtaaaagtg ttattagcta caggtattcc aattgatttt
     8101 gaaaaaagat tggctggttt aaagagcttg gaaacaaatg ggcaattagt tcccgatgat
     8161 acgattcaag caataggaca atttgggtat gcccttaaag gcccatttac gacaccttct
     8221 ggcggaactc aaagaagccc aaattgggtt atccgacaaa aattgaagct attttcttgt
     8281 gttcgtcctt taaaagacct ctctaaaggg atcgacatcg ttattattcg ggaaaatacg
     8341 gaagatctat acggagcaat tgaatgggct tcctccccag atgtcatgca agcagtgaaa
     8401 atagctacta aggacggctg tgaacggatt tccaagtttg caatgaattt ttgcagaaaa
     8461 gaaagaagaa aaaaaataac tattgtgcat aaggcaaata atttaaagct aaccgaaggg
     8521 ttatttcttc agcaagcaaa atctatagct gttgtatatc ccgaaatctt ggttgacgat
     8581 atgctggtgg atacagcagc atatcgtctt gtgactaatc cagaaacatt cgatgtaata
     8641 ttaacttcaa acacttttgg tgacattcta tcgagtgcag gcgctgcatt agtaggcgga
     8701 ctaggtatag ctcctagtgt cagctatggt aaagatgctg tagtagctga agctacccat
     8761 ggtagtgctc cggatattgc aggaaaagga attgccaatc caatcggaat aatatcggcc
     8821 agtgccatgc tcttaaaggc tacgggttta gttcctcagg cagaacttat tgatcaagca
     8881 attaattggg cgtgtaaaaa taatgtgaca acaccagata tgggtggaac ggcgagcact
     8941 tcagaagttg cagatgaaat aacaaaatat ataaaaagta gaggtggttt gtttgcgaaa
     9001 aacaacgatg cttcgtcaat tgtttagctc ccctggctgt attaaagtta taggcgtttc
     9061 tgatggaatc actgctaaga tgggggatca ggctggattc gatgcgctct gggcaagcgg
     9121 cttggcaata tccgcaagcc attgtgtacc ggatgcaagt attttaacga tgtctgagtt
     9181 tctatctgct gctagtttga ttcataaggc aacaaaatta ccagtcatcg ctgattgcga
     9241 cacaggattt ggagaagtaa ataatgtagt aagaatggtc agagagtatg aaagaagcgg
     9301 aatagcagcc gtctgtatag aagataagga atttcctaaa cgcaatagtt ttctggagaa
     9361 tcaccgtctt gcaaataagc atgaattttg tggaaaaatc atggcagcca aagatgccca
     9421 actcgatcct gattttatga ttatcgcgag attagaatct ctaatagcca atgccggaat
     9481 gaatgatgcg ctcgatagag cttttgctta tagcgaggca ggagcagatg cgattttagt
     9541 gcactcgaaa tcaacagaac cgacagaaat aaaagagttt gcttccattt ggaaaatgaa
     9601 gggtggagca aaaccattaa ttgtagtgcc gacaacctac tacaatatta aatgtgatga
     9661 gctttataat gacggtttta aaatggttat ttatgcaaac caggctctaa gggcaagtgt
     9721 aatggcaaca aaagaagcct ttgaagagat tttacgcacg gggagtacag catcaattga
     9781 aggcaaaatt tcatcagtaa aggagatttt cagtctaatt ggcacagacg aattgaaccg
     9841 aattgaatct tggtttcatg aggtcattaa gccgcagttg gacaacaaag tattagcaag
     9901 taaccatact gcaattaaat aatagggtat tcaaatataa tagggggcag caatgttaaa
     9961 ttctcagcaa atcacggaaa aattattgca cgcactgaat ccacttataa gtgaaggaga
    10021 agatatgctc atattgcact ctgctctttc caaattgggc tttgagcggg gagccccgta
    10081 tgtagatgga ttgatggaat ttttgcaggc gctgatagat agaggaataa cagtggtact
    10141 gcccagtttt accttctcgt tcacgaaaag aaaacgattc tgtctaaatc atgatccttc
    10201 agaaacggga atattggccg atctagcgcg taaacattta caattcagtc gttctaaaaa
    10261 tccgatgttc tccttctctg ttaaggggcc gaaggaagat gaaatcttgc taacgcgcca
    10321 agactcaggt tatggaatag gcactgctgt ttcccgcctt gcagcagcgg acacaactgt
    10381 tgtcatgtta ggagcgaatt ggaattgctg tactatcata cacgcgattg aagagaattt
    10441 acaggttcct tatcgtgaat atataaactg gtcctatgag attgatttcg gtgatggggc
    10501 tgccacaagg ccatttaatt tgtttgtacg caaactagac agtaattcta tcttaagatt
    10561 tgatcgcatc cggggagaat tgttgcaaac tggtgcttta cggcaatcaa cattgaatgg
    10621 cctctacatt gaagcggcca atagtgggga tattgcagaa atttctgaga aaaggatgag
    10681 actcgaccct tatttcttta tagaatagga gcatccatat gacaaaaaca gctatgattt
    10741 tatgtgctgg acgtggcatt cgattaactc cattcacgaa caacaaacca aagccactgg
    10801 tagaagtgaa cgggataagc attttagaaa actcgattca acaacttata aatgctggat
    10861 atcaaaatct ttctattgtt gttgggtata agggtgacat gattaaggaa atagtctcaa
    10921 agtactcttc acaattggat attcacatta tagaaaataa tgaatggtca accagcaaca
    10981 atattatgtc actctggaag gcacgaaatg agctgcaggg agatatcaca ttattagaag
    11041 gcgatgtttt ttacgatgaa tcagtgctca agcagttaaa tgatatgccg cttggtgcta
    11101 attacttagt tgtctcccct ttgacttcat ttatggatgg aatgtatgta acagaggaag
    11161 ctggtaaaat atcggggttc tataatacct caaaaaaaac acaccagcac ggaaaagaac
    11221 ctttgaaaag cgtaaacatt tgtcggttgt ccacaaatat ttgtcaatat ctggttgaaa
    11281 gtattcaaaa agaagtagca gcgggaaata tgcaccgctt ttacgacgat ttatttgagg
    11341 atgcctttcg acttggctat gaatttcgcg ttgtaaaagt ggatacgaaa tcctggtttg
    11401 aagttgataa cccttatgat ctgagtttgt gcgaatttca acactctcgc gatccttatc
    11461 aaagattgaa gcaacaacat gggggatatt ggcgacatcc tattactgat tttgcattaa
    11521 tttataacct tcattttcca ccaaagactc tcaaagaaaa aattaaggat agattcgatg
    11581 aaattatact taattacccc gcctcatctg tacctataat acggcatctt tcctatttcc
    11641 taggggtaaa tgatgataag cttgctatag ctaatggtgt atctgaaatt atcaaactat
    11701 taccacgttt cataaaagga aacattgtac ttgttgaacc ttcatttaat gaatatgcaa
    11761 attgctttac tgatgaaaga atcaccacct tccaattgaa ggaaaaagac gatttccagt
    11821 tgaatatata tgatttgatt gaatgtattc tacataatga cgcacaagct gttatattag
    11881 aaactccaaa taacccaaca ggtcgcttag ttaaaaagga agatatcatt aagctttatg
    11941 aagcaacaga gcagcataac atactagttg tgttggatga atcatttatt gatttttcct
    12001 gtagggagac taccgaacaa ttacttcatg atctgcattt atatcctaga attcttctgt
    12061 ttaggagtat gagcaaaaca ttcggaattg gtggattacg tattggttat gcagtctctt
    12121 ctaatttata catgataaag gagcttagat cagagttacc tatctggaat ataaacggct
    12181 tcgccgaaga atttctactc aatcttccac catatcggga ggaatatttc cgcagttgca
    12241 aagtagtacg tcgcgaaaca gataatctgt tagatgcctt aaggcaaatc gacggaataa
    12301 aagcctttga cacagaggca aatttcattt tctgcaaaat acaaaataaa ttgtttaccg
    12361 cggagcaact cgcccataag ctggtacgaa aatatggagt gtatatcaag gaatgctctg
    12421 gaaaaaaatt gcctgattca gagtacttct ttagagttag ctctcgtaca gattcagaga
    12481 atgaacaatt gattcatgca ctatcaacca tctttgagcg ggaatatgat tatactacgt
    12541 aaagtaatgg ggtgctcagt tgaagcgaaa catttcaata ttaggttcca ctggatcgat
    12601 cggtacatca acactagaag ttgtcaagca acatttggat cgttttcgag taattggact
    12661 tgcggctaat acacagatcg atacactaat tcaacaaata caaacgttta aacctaaaat
    12721 tgtctctgta gctacaaaag aaggcgctga aaaggtccgg gatgcaattg atcctgaaat
    12781 tgaagtatgt gttggctctg aggggcttat tgaggtggcg acgtacttag aggttgactt
    12841 tgttatgaat gcattagtcg gaatgaatgg acttcttcca accatcgaag cattaaaggc
    12901 aaagaaggat attggaattg caaataagga atcactcgtc gcagcggggc atttaataaa
    12961 aaaattggcg ttcgaaaatg aatgtatgct ttacccgata gatagtgagc actctgccat
    13021 ctttcaatgc ttaataggag aagaccgcag tgctatcgat aagctcataa taacggcctc
    13081 tgggggggca tttcgtgata aatcaaggtt tgagatggaa cgactatccg ttacggatgc
    13141 tctcaaccac ccgaattgga aaatgggagc aaaaatcaca attgattgcg ccactctcat
    13201 gaataaaggt tttgaagtca ttgaagctca ttggttattt gatgttccat atgagaaaat
    13261 tgaagtattg attcatccgg agagtatcgt tcactccatg gttgaattcc atgatggttc
    13321 tattattgcc caaatgggcg tccccgacat gtttgtaccg atacagtatg ctcttagtta
    13381 tccagatagg ttagataatc gaataaatag attaaatctt gctgagattg gaaaattaca
    13441 tttttatgaa cctgattata tacggtttcc ttgcttagaa gtagctattc aagcagctcg
    13501 tgagggggga tcaacaacaa ccgtattaaa tgctgcgaat gaagtagcca acgagcactt
    13561 tcggcaagga atgattaatt ttttagatat agaaaagatt attattaaaa ccttggaaaa
    13621 gcatgaaaaa gtcaagtttc cttcactgga tgaggtattg gggattgacg aatgggcccg
    13681 ttcattctcg tcccaagtcg ctacatgcta tgtattataa atcattttca ctataatcca
    13741 taggggggaa cgtcgtggaa gaaaatgaat ataaattaac cgtatgcggt tgtgggccag
    13801 ctggagtgtc accattgatt tacatggaag agtatgattt attagaaccg cttcttaaag
    13861 aaggcgtgtg tttaatcgac aagtctaatt ctgttggcag cggaaacata aagaattaca
    13921 aaatcaccgc caactcttta ggcaaagtat tcactgaaat attcacgaat ccacaaagtc
    13981 ccctattgaa atacctaact gataaggaaa gttgcaaaga gttatcccac ttcaaagatg
    14041 atccccctaa tttaccttta gtcggtaagt taatggacga tattggcgat tacttgtcgg
    14101 agaaaataaa aagttttgcc caaagtaaag tgttattaaa tacgacggtt acacaaattc
    14161 acacacgtct ggacggcaga tacgacatcg ttttcaatta tggagactct aaggattcct
    14221 ctgcaaaact tacaacagaa catttgttat tcaatttagg aggcttacaa gagttccccc
    14281 ctttcatttc gcaaaaaacg gcatcatccg gtcatgtatg gctctcttct gattttatta
    14341 tgggaaaatg ggatcatgat ctattatctt tactgcaaag atccactaac actttaaaca
    14401 tagctgttat aggagcttct cacagcgcgt tttcaatatt atatcgactg aaaaaccatt
    14461 tcaatcttat accaggatcc caaattgacg tcaatatttt acacaaaagc cctctgcgtc
    14521 tcttctataa ttctatagaa gaagcgtcac aagctgggta tcatttcgat tgcaaaactg
    14581 acgtatgttc ccattcggga agagtaaatc gcttttcggg cttacgatat gattccttcc
    14641 aactagcgag ggatgtactt gacgggaaat ataataatgt acgtttgagc ccggtttcta
    14701 agtctggacg aagtgacgaa cacgaatata tcaatcgggc tgacattatt attgtaagca
    14761 ccggttataa aaaaaataga gtccaaatat tcgataaaga tgggtcactt ttatcacttg
    14821 ctatggatag caacggtgtc ataaccaata attattgtaa tcctatttta caaaacggtc
    14881 gcgcactcca aaacttttat acttatggtc taggtgctgg gcaacgggtc aatgcggaaa
    14941 acggaggcga aacatcttac acaggaagaa tagacggaat ctggttctac cagcatgaag
    15001 taacaaagcg catcgttcct atcattactt caaaagttaa gcaattacta gagagtaaaa
    15061 ggcggaggtg atctatttgt ttcatgcaag tattgttatc cccactttca accgttcaaa
    15121 gctactggaa tacacaatta aatcactact gaaacaaaat gcttccccgt atatgtatga
    15181 aattattatt gttgatgatg gatcaacgga tgaaacacaa caaatggtac agaagtatat
    15241 ggaaaacaat catatagttt atttttttca agataaaaaa ggatatcgag tatcttctgc
    15301 acgtaatacc ggaattaata atgctcgggg aaacaccatt atttttttgg attctggcat
    15361 gctggtcggg tccaacttcg tatatgaaca ctgccgagct catgatagta gggccacgga
    15421 taccgttata attggatata tccatgggtt tcaagctaat gaagaagatc acacctttat
    15481 tgaacttgta gattttaatg acattgacca tactttacaa cgaatcaagg agtcaggatt
    15541 gtatcaagat ttgagagagg ccggattcac attttttcaa gatcatattc aaaatagcga
    15601 tgcgccttgg tactactttt ggacgggaaa tgtttctgta caaaaaaatg tcctgcaaaa
    15661 gcatggggga tttaatgagg catacaatac atatggaatg gaagatcaag agctaggatt
    15721 tctgttgtat gacaatggac ttgatttcga attgcatcga gctgctgaag caattcatta
    15781 tccgcacgag actttcgcta aggcagacaa aaaggcttcc ggagaaaaaa acgccttcaa
    15841 gttccacaag aaatacaacc gacttattac tgaacagttt tatttgagtt taaatcgaaa
    15901 atttaatgaa gaactgtatg atttgaagca aaaaggagac actcgaataa attataatac
    15961 atcctatttc gataaatttt ttaagagttc attttgtgaa aataacggga gggctatact
    16021 gtttggcggc cataatggtg ccctcctaaa tttcttacaa ttcggatatg ttctcgaata
    16081 tcatcaacca tactttgaag aattgaaaag aaatcacctt gacagaagtg tttaccaact
    16141 aatgggcgga ataacgccat ttcctgataa atatttcgaa tatgttttca taacggatta
    16201 ttggaattgc gtagacacaa aatggcttcc caaaataatg aaagaagctg tgcgaatagc
    16261 aaacgtcgtc catatcatta ccgaaataat ttataacaat tcctatgttt tctcgcctca
    16321 aaaaaataaa cagcttgatt tgttggaggc gcttcgctca tataacttgt ctccccattt
    16381 atgtcaaaag caaaatggtg aactggaaat gacatatttg gaacttagga gctgaatatc
    16441 aaatgagtat cgtatcagtg aataatttgt acaggcatta taaagtatta aatagaagag
    16501 ccggatttat tggtaatata tctaatttat tttcgaggga ttatcggacg gtaaaggctg
    16561 ttgacgggat ttcaatggaa tttcaagaag gcgaaattgt tgcatttgtt gggccaaatg
    16621 gagccggtaa atcaacaact attaaaatga tgacaggcgt attagaacct acttcaggaa
    16681 acatattggt aaatgggatc attccttata aaaacagagt gaagaacgct gaaaatattg
    16741 gagtcgtatt cggtcaaagg tgtcaactgt ggtgggatct acctgtcata gaatcattta
    16801 aactacttaa gcttatttat aaaattgata agaatgatta tgaagctaat atgagtatgt
    16861 ttgacgaagt tttaaattta aagtctctat atactactcc agtaaggttt ttatcattgg
    16921 gtcagagaat gttatgcgac attgcagcag catttttaca taatccgaaa gtaatctttc
    16981 tagatgagcc gactatcgga ttggatattt cagttaaatc caaaattagg gagtttattt
    17041 taagactcaa tgttgaaaaa aaaacaaccg tattccttac cacacatgat ataggggata
    17101 ttgaggcatt atgtgaacgc atcattctaa ttgataaagg catgataatt tatgacggat
    17161 ctattcaaaa aataattaac ttatatggtg catatcgaac attaaaaata gaatttctgg
    17221 gggaagatga aacaatcggc atacgcgtta tagccgagct ggaaaaagga ttggaaaact
    17281 tcaatcgtat tgctgtcgac cagcaagaaa gtggctggct tcaacttact tttaatcagg
    17341 agaatattga actcgtagat atcatgaacg taattttgaa gaaattcaaa gtcaaagata
    17401 ttaaactgga agaagttaaa acagagagca ttattaagaa agtatatgaa agggaattat
    17461 tgcatgctta agtatatggc tattgcgaaa ggtgagtttt tgtccaggtt atcttatcgc
    17521 gttggagcta tctttacttc at
//
