LOCUS       NZ_CP086145            16351 bp    DNA     circular CON 20-JAN-2024
DEFINITION  Clostridium estertheticum strain CF016 plasmid pCF016-16, complete
            sequence.
ACCESSION   NZ_CP086145
VERSION     NZ_CP086145.1
KEYWORDS    RefSeq.
SOURCE      Clostridium estertheticum
  ORGANISM  Clostridium estertheticum
            Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 16351)
  AUTHORS   Wambui,J., Stevens,M.J.A. and Stephan,R.
  TITLE     Clostridia strains as spoilage organisms
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 16351)
  AUTHORS   Wambui,J., Stephan,R. and Stevens,M.J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2021) Institute for Food Safety and Hygiene,
            University of Zurich, Winterthurerstrasse 272, Zurich, Zurich 8057,
            Switzerland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2021
            Assembly Method                   :: unicycler v. 1
            Assembly Name                     :: CF016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Nanopore/Illumina miniseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/20/2024 05:10:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,249
            CDSs (total)                      :: 5,114
            Genes (coding)                    :: 5,019
            CDSs (with protein)               :: 5,019
            Genes (RNA)                       :: 135
            rRNAs                             :: 15, 14, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 14, 13 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 22 of 95
            Pseudo Genes (incomplete)         :: 78 of 95
            Pseudo Genes (internal stop)      :: 14 of 95
            Pseudo Genes (multiple problems)  :: 16 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:27:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 16351
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086145.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     gene            join(15249..16351,1..82)
                     /locus_tag="LL065_RS26195"
                     /old_locus_tag="LL065_26185"
     CDS             join(15249..16351,1..82)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361975.1"
                     /locus_tag="LL065_RS26195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_26185"
                     /product="ABC transporter permease"
                     /protein_id="WP_268064808.1"
                     /transl_table=11
                     /translation="MNKLVSVILLKELKDMLRDKKTIIVSLLIPLLLMPVLSFIMGKTM
                     NSAKDDVNQNTKIVMVDKGHSSLGKILKKDKSIKFISGTDGKGAVKDGKALLSIEIPKD
                     FDAFISKGNNSGIKIFYDNTSQKSSIALSKVTGIIDELSKEIVGSRLTKRNIDIKILTP
                     ITVAKTSFQKEENAAGQIVLGMLIPIFVLLYSATGTIAAATDLGAGEKERGTLEPLLTT
                     KAGRHYILTGKLYAITIMGFIVSVCSMIGILVSMKIPGGMFGNGSTAIALGYKAIALIG
                     VISIITTMFFGALELAVSVYARSFKEAQTYLTPFSIVPIFAVYGTMYMDAKNIPFLYFN
                     IPLLSVSSVVKELTSGIYNYGHIGITIGWSIVYTIVAIIFARHMFNKESVIFRS"
     source          1..16351
                     /collection_date="2021"
                     /country="Switzerland:Zurich"
                     /db_xref="taxon:238834"
                     /host="bovine"
                     /isolation_source="feces"
                     /mol_type="genomic DNA"
                     /organism="Clostridium estertheticum"
                     /plasmid="pCF016-16"
                     /strain="CF016"
     region          1..16351
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..16351
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..16351
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10951:13732](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10952..13732)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    518..536
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 25.92"
                     /tool="antismash"
     misc_feature    747..762
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.26"
                     /tool="antismash"
     gene            complement(1649..2170)
                     /locus_tag="LL065_RS26200"
                     /old_locus_tag="LL065_26190"
     CDS             complement(1649..2170)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS26200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_26190"
                     /product="hypothetical protein"
                     /protein_id="WP_226140815.1"
                     /transl_table=11
                     /translation="MLNSINEISISLGVSKMTIYRKLKVKELKSHIILKQGIQYIDDNG
                     LTMLIGMLKPSRESVKCDVKEECTTNITNDEIATDKADFISSLKSEIDFLRSELQEKNI
                     QINNLSMGLSSEQELHKNTQILFKQQQPQQILQLEAHFEELDNKLIEIKDKMKDKQKDH
                     KGIFKKIFSK"
     misc_feature    1662..1676
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.54"
                     /tool="antismash"
     gene            2555..3628
                     /locus_tag="LL065_RS26205"
                     /old_locus_tag="LL065_26195"
     CDS             2555..3628
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013235.4"
                     /locus_tag="LL065_RS26205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_26195"
                     /product="replication initiation protein"
                     /protein_id="WP_226140816.1"
                     /transl_table=11
                     /translation="MVKNNLIVKSNYIVEASYKLSVGEQRVIYVLTSMINKDDADFKLY
                     KFTAKEFANIIGTKSKNIYSQVSQYVEALRDRDLTIIKEKSILKTKWLSSAEYFVDEGY
                     VELEFSPKLKPYLLLLKKRFTKLSLEQMVRFNSQYSGRIYELLKQYQIIGLRIFRIEDL
                     KSLLGIEIGEYKLYGDFKRKILVKAQKEINHDSELFIDFEEIKKGRKVESIKFIIKTNL
                     KAISEVCASKEGKYINEEEKYHTELINMVKSMFKESITGKEAKFILNTAKSDINIIKEK
                     YDIVSKMKKVDSVVATMIDAIRKDYQAPKGKENGGSFNDYEQRSYDFDDLERKLLGWDK
                     EEMNKETGEEFQQLAMK"
     misc_feature    3846..3857
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.13"
                     /tool="antismash"
     gene            3889..4806
                     /locus_tag="LL065_RS26210"
                     /old_locus_tag="LL065_26200"
     CDS             3889..4806
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS26210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_26200"
                     /product="hypothetical protein"
                     /protein_id="WP_226140818.1"
                     /transl_table=11
                     /translation="MADEKSTVLGIRLDIEERKRFDEFVGEEGKNNKDFLNTLLNLYEL
                     NKGKVKNINLVGDIDVLEGYTNKIHQAFINVIDKLESQKCDISENGQKNLQIYKDKVSD
                     LQNEITSVTLLNSMNEEKLIILNNDNVALKEKHNQLQESSQDKLTIIKEYQGKNDTLTG
                     ILEEYKQYKVEVEEYKKLLADTQSKNIELKDSIKDKDATVNNLSKDIVNLKEGHEKAVN
                     GLTKSQEQLKDKHIEDIQQLKEKASITMDKALLKLQKEQQDQLSQNQLKYNEEIEEYQS
                     KYKSLLEEMEKKKPTPRVKKIVQR"
     misc_feature    complement(5162..5181)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 21.23"
                     /tool="antismash"
     gene            5609..5971
                     /locus_tag="LL065_RS26215"
                     /old_locus_tag="LL065_26205"
     CDS             5609..5971
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS26215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_26205"
                     /product="hypothetical protein"
                     /protein_id="WP_226140820.1"
                     /transl_table=11
                     /translation="MLKKISVFLLSLVLMVGFTLTTISPTKVKAATLHNGYVSSKYILI
                     NDPFCYSYYGFSSGIVKLDASISTLSVMDSELEAANIIDSLPDGYPFTVSSGRGMFSPP
                     IIGPVSPVSYHITYSK"
     gene            7596..7943
                     /locus_tag="LL065_RS26220"
                     /old_locus_tag="LL065_26210"
     CDS             7596..7943
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003488634.1"
                     /locus_tag="LL065_RS26220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_26210"
                     /product="DUF6483 family protein"
                     /protein_id="WP_226140822.1"
                     /transl_table=11
                     /translation="MNIEKLIEDLGKAFGKIIFNKKEDVSEKINIDQMSSTDIFKIIFN
                     KLFHMGNYNKSEDLIFDELEKNNSPEVYEVAIEFYNSLLKKSDEELNISNFPRKEIYRG
                     LDDIQKFKVDL"
     gene            complement(8074..9129)
                     /locus_tag="LL065_RS26225"
                     /old_locus_tag="LL065_26215"
     CDS             complement(8074..9129)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="LL065_RS26225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_26215"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_226140824.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.9e-43, bitscore:
                     137.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKAIELNNQYEVWRWDIDKVTNNRESYKIQQGNHKVKVAIIDS
                     GIDQNHPDLKDNLISSKSFVPGSKSLEDSLGHGTMVAGEISANGNVKGVAPKIAIASYK
                     VFDGNDCNSIWVINAIIQAANDNMDVINLSLGTYKSLLNKNDLAMLLAYKRAIAYAQSK
                     NCVVVSASGTESKGMDISNPFNLAQELGHEKDLGIYLPGCLPNVITVSATNKDDKLASY
                     SNYGYNVGIASPAGDYGPNWTTQKIANLKYMALVTYPTNLPQSQLSSSIGLKQGYEFIE
                     GGTSIAAPKVSAAAALLILEYNEKYGFKPSVLEVEKLLYDGATPGAEGSNPLYYGKGIL
                     NVENSLKLIGK"
     gene            complement(9861..10040)
                     /locus_tag="LL065_RS26230"
                     /old_locus_tag="LL065_26220"
     CDS             complement(9861..10040)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS26230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_26220"
                     /product="hypothetical protein"
                     /protein_id="WP_226140826.1"
                     /transl_table=11
                     /translation="MIKEFDPAGIVDLSELDELANIGGSDVQAQTTPTIASFLVSVISI
                     ELTASAVTVTAACL"
     CDS_motif       complement(9966..10040)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIKEFDPAGIVDLSELDELANIGGS"
                     /locus_tag="LL065_RS26230_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9861..9965)
                     /prepeptide="core"
                     /locus_tag="LL065_RS26230_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.50"
                     /molecular_weight="3241.7"
                     /monoisotopic_mass="3239.8"
                     /core_sequence="DVQAQTTPTIASFLVSVISIELTASAVTVTAACL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIKEFDPAGIVDLSELDELANIGGS"
                     /leader_location="[9965:10040](-)"
                     /alternative_weights="3259.7"
                     /alternative_weights="3277.7"
                     /alternative_weights="3295.8"
                     /alternative_weights="3313.8"
                     /alternative_weights="3331.8"
                     /alternative_weights="3349.8"
                     /alternative_weights="3367.8"
                     /alternative_weights="3385.9"
                     /alternative_weights="3403.9"
     gene            complement(10169..10900)
                     /locus_tag="LL065_RS26235"
                     /old_locus_tag="LL065_26225"
     CDS             complement(10169..10900)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015325.4"
                     /locus_tag="LL065_RS26235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_26225"
                     /product="flavodoxin family protein"
                     /protein_id="WP_226140827.1"
                     /transl_table=11
                     /translation="MKKLVAIIGSPRGYNSKTYEIAYKISEGLENKNINISSKFFILSE
                     LEINKCTGCLGCFAKCSSCVSFSDSMDVLEKSMLDADLIIFGSPVYAHNITGDMKIFFD
                     RICHFLHTMKLVGKYGVTISTSSSNGNIFVNDYLLKMMEYLGIGVIDQISYISQREFEE
                     KHITKCIDNIAGVLNGQISLPPSKFKEQIFNIYKKIYFENYQKSLMNKNTMKNQEACYW
                     HDNGYFNYNSFEELFNVMKNK"
     gene            complement(10952..13732)
                     /gene="lanM"
                     /locus_tag="LL065_RS26240"
                     /old_locus_tag="LL065_26230"
     CDS             complement(10952..13732)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018081 - peptide cross-linking via
                     lanthionine or 3-methyl-lanthionine [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="LL065_RS26240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_26230"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_226140830.1"
                     /sec_met_domain="DUF4135 (E-value: 5.1e-95, bitscore:
                     308.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.3e-44, bitscore:
                     140.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSFFDTIPEESRMFPEFFSLYLNEFDSRLSVLSNEGSGIISFNG
                     IYGYLYTNLLNYSIRTLIKELHDYKNKNLLTGETPRERFVSFEKIIENEHFMTHFYEKY
                     PVLKLLLEQKIRETVLYVNEIIINFKNDKIELERKFKVKFKKIIDIHLGKGDTHNGGKS
                     VAIIEFDSGKIVYKPHSLSPDIVFKNIIDWVNSKDVLKCNLNSLKVIDYDNYGWQEFIS
                     YGECKSYIEVENYYYRAGCFLAIFYTLGTNDIHFENIIVNGEHPYFIDLETLVGISNPG
                     QIDSVLTSGFIPNRSSNNLFDMDLSGLCGKMQISSKLKTMAIANPKTDEMIVETQPARI
                     YSNNNIVRLNSEIVKVEEYTSNFIKGFQDAIELIIDNKNSYIRLIEKEFNEFQKFRQVI
                     RHTQVYAKFLIAASHPDYLKNEDKHVELFQRLYNGCKDDLKHKRISNEISTLLKWDIPY
                     YYCYYDSKDLLSDNILIHKDYFQSTIKKSLYTRIEKINSNVKNFQIDIIKKSLFTVYED
                     KFMNKEFNRVKFCSNNSDLNKEIIMKIANSISSNALDLKETDKIAFLINTTENNQVLLA
                     NINFNLYEGGGIIWLFACLGKLFDNNNYENISMKLLESSVLTYEYYDMKQTNLRRLTAF
                     SGIGSLMYLYYNMSVLYDNEDYYLKFTNIANKILEYNCDYLKTSNKSLDYDFVCGISGI
                     LVLAAKIYLNEKNYLMEKIIDIYSDYLLKYINNNNLNKIGLAHGLSGYSLALIMIYRVK
                     KDRVYLDLATKLINKENLIYSSNGKTDEFTTSWCNGETGMALVRNEMLKIEHNSKMLND
                     TLKYLQIIITNGFYNMNSMCLCHGIYGNIEIVNQIINNIDETHKIITNDEVKKFETSLI
                     NNLSDIQLGLKNNFMLDTFMLGSSGIAYAKLRYLYPQIPSILSLDIIERNCKHFE"
     misc_feature    complement(11034..11047)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(11974..11983)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(12963..12977)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.73"
                     /tool="antismash"
     gene            complement(14237..14374)
                     /locus_tag="LL065_RS26245"
                     /old_locus_tag="LL065_26235"
     CDS             complement(14237..14374)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS26245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_26235"
                     /product="hypothetical protein"
                     /protein_id="WP_268064807.1"
                     /transl_table=11
                     /translation="MQSNLKQLPIVYIYTDIDEYFEQDKPKLIKLFDKYIYLYELRNNL
                     "
     gene            14528..15256
                     /locus_tag="LL065_RS26250"
                     /old_locus_tag="LL065_26240"
     CDS             14528..15256
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010073538.1"
                     /locus_tag="LL065_RS26250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_26240"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_226140832.1"
                     /transl_table=11
                     /translation="MLEVKKLTKKFKSFTAVDGVSFVANGGEILGLIGENGAGKTTIMR
                     MLATMLKVTEGEGQISGHDLVKEPESIRGEIGILFGGEVGLYDRLTARENIMYFAKLNG
                     MSEGDAKKSIEELTRELEMNEFIDKRVGKFSRGMKQKVAIARSIVHKPSVMLFDEPSTG
                     LDVSATRLIQDFIFKCKSEGKAIVFSSHSMTEIEKLCDRVVIIHKGKVVEHGTISALKV
                     KYNNEDMEDVFVNLIGGNHE"
     misc_feature    14846..14855
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 14.79"
                     /tool="antismash"
     misc_feature    15527..15546
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 18.33"
                     /tool="antismash"
     misc_feature    complement(16239..16252)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.72"
                     /tool="antismash"
ORIGIN
        1 ctggtccata gtttatacta tagtagctat tatttttgca agacatatgt ttaataagga
       61 aagtgtaata tttagatctt aataattaaa tctgggtgtt tttgcctatc ccgccaaaaa
      121 ggtatattag tggcaaaata tattattaat atggattttg aacgttttga aagttacaca
      181 atgcatttgt gtaactttca ctttccttat ttagcaacga ttttgaatat tttatatgaa
      241 aagcatagat tgaatgttaa ttaatactaa taattgatat tgttatgtaa cataacttct
      301 actttgctcc taactcataa ccttaaatat gctaatatac ctttttggcg ggtaaggtaa
      361 aaacacccaa tatctttcat ccttctttta aagcaaacaa tgttacacat gatgtcttgt
      421 accatttttg ttttggactt gctttaaatt cggttttaaa acgtgtattc gctcttttaa
      481 ttttgactta ctctatttta ttgttattct aatcatttat ggtataaaaa aacagtatct
      541 aaacgatact gtaatatatt atgtctttag gtgttattgt tttattattg gtctatgtct
      601 tctgtaggca agttagagtc aagtagaaaa accgaattta ttcgtcttgc tttcttgatg
      661 aatatcttct ctatgttcag atattcatca agaaagtttt tactacggtg tgaaggcatt
      721 tatgccagaa gatgaatcta acttgcctac cccttctggg aatttatatg tgcaccattt
      781 ggtgctatat gaattattgt ttaattttct tttatatacg ttggtacaac tagatatatc
      841 gtttttttaa ttgacggatt ttttcttgaa aatattaatt ctttaacacc acattttttt
      901 aatacttaat ggaaacatat ttcattattt ctggtgtcta ttattacttg attaatatac
      961 taaaatagta ccatatatta tgagtgtatt acaagctttt tagtattgtt tataacaata
     1021 ctatactact taaatattag cattttacta cgaaataaga acaataaact aaccagagag
     1081 ttaaccccct ggttttctat taaataggtc tgggttttat aagttttaaa gactatattg
     1141 cctaaattat gtaaggaata atcacaccaa ataatacacc cataacatat gatctaatcc
     1201 gatataatct ataatgatac cattatgtat tatttaagct agtaatacca acggttgtca
     1261 aaacatactt aacctaatat ataatgatgg ctgcatattt aaattattaa ttgtgctagg
     1321 acctagcacc ataatatatt tgttatttaa caaatatatt atcctttagc ctttcacatc
     1381 tagctatagg gcatccttta aaaatggctt tattactagc ctaatacatg gttattctta
     1441 aagttttatt aaaacgcttc ccttatcaat ataaaaattg aaaatggctt ccctactcta
     1501 atcattattg ttacaggctt tgcctttaat ctgtagctga aagcgcctcc cccttatcct
     1561 gccttttctt aatacttacc tatatttaaa attctcatgt aattattttg tataaattta
     1621 tagcgaaaat attcttaaca tagcctaatt atttactaaa tatttttttg aaaattcctt
     1681 tatgatcctt ttgtttgtct ttcattttat cttttatttc aattaattta ttgtccagtt
     1741 cttcaaagtg agcttcaagt tgtaatattt gttgaggttg ttgttgttta aataatattt
     1801 gtgtgttttt atgaagttct tgttcagaac ttaaccccat acttaaatta tttatttgta
     1861 tgtttttttc ctgtaattca cttctaagaa aatctatttc actttttaaa gaactgataa
     1921 aatccgcttt atcagttgca atctcatcat ttgttatgtt agtagtacac tcttctttaa
     1981 catcacattt aacactttca cgtgatggct ttaacattcc tattaacatt gttaaaccat
     2041 tatcgtcgat gtactgtatg ccttgtttaa gaattatatg tgactttaac tctttcactt
     2101 ttaattttct atatatagtc atttttgata cacctagtga tattgatatc tcatttatgc
     2161 tatttaacat acgaatacac ctactctata acagttttat atattgttat agttctctgt
     2221 tatattgtta aagtcctttt agcctgaaaa ataagtcttt attttcaggc taaattttaa
     2281 agaaaactag taaaaaacta cagttgttgt tttaaaggtt ttaaacagta cttgttttaa
     2341 aggttttacg tcttattgaa agcattgata tgactggggt tcattaagtt aactatgacc
     2401 aaaaaggggt gaactatgac caaaaagggg tgaaatagag agttaactat gaccaaaaag
     2461 gggttaacta tgaccaaaaa ggggcagaaa cgactagtat tatgacttga catttttaag
     2521 gtcataatat acaattttac tgaggtggta atgtatggtt aaaaacaacc taatagtaaa
     2581 atctaattac atagttgagg cttcgtataa actaagtgtt ggagagcaaa gggttatata
     2641 tgttttaaca tctatgatta acaaagatga tgcagatttc aagttgtata aatttactgc
     2701 aaaagaattt gcaaatataa tagggacaaa aagcaagaac atatatagcc aagtgtctca
     2761 gtatgttgaa gctttaagag atagagattt aactataata aaagaaaaat ctatattaaa
     2821 gactaaatgg ttaagttcag cggaatattt tgttgatgaa ggatatgttg aattagaatt
     2881 ttcaccaaag cttaaaccat atttattatt gcttaaaaag agatttacaa agctttcact
     2941 agaacaaatg gtacgtttta atagtcaata ttcaggaaga atatatgagc ttttaaaaca
     3001 gtatcaaatc atagggctta gaatatttag aattgaagat ttaaagtctc tactaggaat
     3061 agaaattgga gaatataagc tatatggcga ttttaaaaga aaaatattag taaaagcaca
     3121 aaaggaaatt aatcatgata gtgaattatt tatagatttt gaggaaatta aaaaaggtag
     3181 aaaagtagaa agtataaaat ttatcataaa aactaattta aaggccataa gtgaggtttg
     3241 tgctagcaaa gagggcaaat atatcaacga agaagaaaaa taccatacag agcttataaa
     3301 catggttaaa agtatgttta aagagagcat aacaggaaaa gaagctaaat ttatattaaa
     3361 tactgccaaa agtgatataa atattattaa agaaaaatat gatattgtat ctaaaatgaa
     3421 aaaagttgat agtgttgttg ctactatgat tgacgcaata agaaaagatt atcaagcacc
     3481 aaaaggaaaa gaaaatggtg gtagttttaa tgattatgag caaagatcat atgattttga
     3541 tgatttagaa agaaaattat taggttggga taaggaagaa atgaataagg aaacaggaga
     3601 ggagtttcaa caattagcaa tgaaataaga aaagcaaaag tgtaaactga tatcggtttt
     3661 acactttttt tattccaagg cggttgctta cttttataat cattatcaag atatttaata
     3721 tataatctac ttataactta aaatcctcaa aacgcgttgc aaaaggcttt ataatggtat
     3781 aggatgatca tatgttaaca atacagtgta aacatatgtt aacgtagtaa taaaaacact
     3841 ttatggaaaa cgttatgtta acaatattaa aaaggaggca tttttataat ggctgatgag
     3901 aaaagtacag tattaggaat taggcttgat atagaagaac gtaaaagatt tgatgaattt
     3961 gtaggtgaag aaggtaaaaa taataaagat tttcttaata ccttgttgaa tttatatgaa
     4021 ttgaacaaag gaaaagtaaa aaacattaat ttagtaggtg atattgatgt tttagaaggg
     4081 tatacaaata agatacatca ggcatttatt aatgttattg ataaattaga gagtcaaaaa
     4141 tgtgatattt cagaaaatgg ccaaaagaat ttgcaaatat ataaagataa agttagtgat
     4201 ttacaaaatg aaattacttc agtaacccta ttaaattcaa tgaatgagga aaagctaata
     4261 attttaaata atgataacgt agcactaaaa gaaaaacata atcaattaca agaaagttcc
     4321 caggataaat taactattat taaggaatac caaggcaaga atgatactct tacaggaata
     4381 cttgaagaat ataaacaata taaagttgag gtagaagagt ataagaagtt actggcagat
     4441 actcaatcta aaaatattga attaaaagat agtattaaag acaaggatgc tactgttaac
     4501 aatttaagca aagacattgt taacttaaaa gaaggtcatg agaaggccgt taatggattg
     4561 actaagagcc aagaacaatt aaaggataaa catatcgaag atattcagca gttaaaagag
     4621 aaggctagta taacaatgga taaggcatta ttaaaactac aaaaggaaca gcaggatcag
     4681 ttaagccaaa atcaattaaa atataatgaa gagatagaag aatatcaaag taaatataaa
     4741 tcactattag aagaaatgga gaagaagaaa ccaactccaa gagttaaaaa aatagtacaa
     4801 cggtaaaaac agttaaatga tatttataaa taaaaaagaa actcataaga gtttctgttc
     4861 ttaaacaatt ttgaattggg agattattgt ggtaagctcc caaatccaat tataatataa
     4921 atgttagggt aagtaaatat gaaagcttta aaagaaattt taacgatggt taaaacaaaa
     4981 cggtagaaga aaaagtaaat ttaaacttgt accaagttta aataaagatt ctgttttaat
     5041 cataattaca gaatgaaggt attaaaaata gtagggcaat aatttaaaat aagtaaactt
     5101 aatgtagata gtagttttta gtattagcag gattatggta agcgtacgct tacccgacct
     5161 cttaggggga aaattcccct aagaccctta ctaacttagg ggaaaatccc ctaaaaccct
     5221 ttaatctaaa gattctaaat aattttaaat aaaaatgaga aaatcaacag cttttatttt
     5281 ttatacttct gttaacccat tatttttgcg tatgctaccc catctccaaa acgctttata
     5341 tctacagcca atttcaaatt tttttcttct gtcatgtata cttcccacca cggtgtcgtt
     5401 ttattgtctc tttaataata acatttttac aaatgggggg gttattttta tagagtgttc
     5461 ttagcttgat ggctatgttg ccgtacccct aatatacatt tttgacggga taggcaaaac
     5521 taccccagta gcaaaagaat ttctgaattt attaggcaaa ttttacagca tatggtacaa
     5581 ttatcctcat aagaatggag gtgtaaatat gttaaaaaaa atatcagtat ttttattgtc
     5641 attagtattg atggttggtt ttaccttaac tacaatcagt cccacaaaag ttaaagcagc
     5701 tacgcttcac aatggatatg tatcatcaaa atacatatta attaatgacc cattttgcta
     5761 ttcgtattat ggattttcga gtggtatagt aaaattagat gcttctatta gtactcttag
     5821 tgtaatggat tctgaattag aagctgcgaa tataatagac tcattgccag atggctatcc
     5881 ctttacagtt agttcaggta gaggtatgtt ttcaccacct attattggac cagttagccc
     5941 tgtgtcgtat cacattactt attccaaata gaattttagt gtcaagcatt tttgaaaata
     6001 tcccgaaata agtgaaacat tagcaccaac taattgttgg tgctttgctt ttccaaaatt
     6061 acggtatttg agggggctgt gtagtaacgt aaggaaaaaa cacagaaaat atacgttaag
     6121 acattattac caacaatata ttttatcgaa atattctgag ttagaactaa tactaaaaag
     6181 ttctaactca agaaaatata taatatcagt gtaaggcatt gaaatatata gggtctaccc
     6241 agtaaatgat aatgcttttg ttgattctct caaaatgagt tagttaaatt atgataatag
     6301 tattgataaa gctaactaaa atatttatta gctaatataa aatctttggg aaaatattaa
     6361 attaacggtg atgtatttaa tattttccat gaatccatcg tcgctttggt aatatgtgtc
     6421 ttaacgtata aaatccgcgt ttcgcggtta ctaccccaga aagaatatat agtacttaat
     6481 ttgagcttaa atttatgaat atcattattt tctgtgctta taccggtttt ctgttccatt
     6541 actacacaac caccgggtat gagaaaaaaa ttaatttatt ttttcaattg aatatgctta
     6601 cataaaatta tgtttatcca ttattgttga aatatgtata ataagagtgt attatatagg
     6661 agtataggtg gtaatggaac caaaaacggc tataaggggt acctgcatca atacgcgaaa
     6721 attgtacgct aaggatttaa aaatcataaa gttcttaatt tttataatct aaagggtgtt
     6781 atctactctt cgtttttatc aagccttttc catccaaaag catgtattgg ggtagcatac
     6841 gcaaaactga catttcgtac gttaagaaaa acagccccat aaatgcaact atttaggttg
     6901 taaagtgctt agtttaacaa tttaaatctt ttaaatgctc aattcgattc aatttaaatt
     6961 aaagttatga tgtcctaaaa aatcaatatt tttccatcaa gtgagtagtt attattatca
     7021 taaactcact tctaaaaggt gtctcagagg tcacaatatc aatatactat atttgtaata
     7081 tatcagataa aacaatatat taaaatatac aataagaaaa aaggctttag tttaatctac
     7141 tataagccct tatatatcaa cgatttatgc tgtttttacg aatgtaaggt tttgcttaaa
     7201 agattacatt cgcatataaa tattttaaaa ttagaattca taaaaatagt tagatctata
     7261 agttcaacaa gtaaaacaat tacattcttg taattaactt tcccttaacg tacgaaatat
     7321 cattttcgct gatgataccc cgtattgttc ttattccagc aatacatttt catccctaga
     7381 ttatacactt agagtggttt ttttagttat cttgaatact tatatatata gttttaagta
     7441 ggataaccct gtaaatatta tttattaagt ctcttttttg atacaaactg tctatatagt
     7501 tagcttaaat gtagaaattt tactcatgtc atggtttttt acaagaatcg gttgccataa
     7561 cccatatata ttttaaataa taaaggagca gtattatgaa tattgaaaaa cttattgaag
     7621 accttggaaa agcatttgga aaaattattt ttaataaaaa agaagacgta agtgaaaaga
     7681 ttaatatcga ccaaatgagt tcaacagata tattcaaaat aatttttaat aaattatttc
     7741 atatggggaa ttataataaa tcagaagatt taatttttga tgaattagaa aagaataatt
     7801 cgccagaagt atatgaagtg gcaattgaat tttataattc attgcttaaa aagagtgatg
     7861 aagaattaaa tataagtaat tttccaagaa aagaaattta tcgaggatta gatgatatac
     7921 aaaagtttaa agttgattta taggtcgagc ctgtaaatat tttttgccta aagaaagagt
     7981 agatataaat ttatttacag gcccaaaaat tgaaaacctt attgtggcta tttttttcac
     8041 gaatcggttc catacccctg ttaattaaaa agattatttt ccaattaact tcaaggaatt
     8101 ttcaacattt aaaattcctt ttccgtaata taatgggtta ctcccttcag ctcctggagt
     8161 tgcaccatca tataataatt tttctacttc tagtactgat ggtttaaaac catatttttc
     8221 gttatattct aaaattaaca atgctgctgc agctgaaacc tttggtgctg caatacttgt
     8281 cccaccttca ataaattcat aaccttgttt taatcctatc gacgagctta actgagattg
     8341 tggcaaatta gtaggatacg ttactaatgc catatatttt aaattagcaa ttttttgtgt
     8401 tgtccaattt ggaccatagt ctcctgctgg tgatgctatc ccaacattgt agccataatt
     8461 tgaataggat gccaacttat catctttatt agtagcagaa actgttatta cattaggtaa
     8521 gcaccctggt agatatatgc ctaaatcttt ttcatgtcct aattcttgtg ctaaattaaa
     8581 aggatttgat atatccatac ctttagattc tgttccagaa gctgatacaa ctacacaatt
     8641 tttcgactgt gcatatgcaa tagctctttt atatgcaagt aacatagcta aatcattttt
     8701 atttaataat gatttatatg tacctaaact taaattaatt acatccatgt tatcatttgc
     8761 agcttgaatt atagcattta ttacccaaat agagttacaa tcattaccat caaacacctt
     8821 ataagatgct atagcaattt taggtgccac accttttaca ttaccattgg ctgatatttc
     8881 tccagctacc attgttccgt gtcccaagct atcttcaaga gatttacttc ctggcacaaa
     8941 acttttacta ctaattaaat tatcttttaa atctggatga ttttgatcta taccactatc
     9001 tataattgct actttaactt tatgatttcc ttgttgaatc ttataacttt cacgattatt
     9061 tgttacttta tcaatatccc atctccacac ttcatattga ttatttaatt ctattgcctt
     9121 attattcaag ctaaatttat ccttaataaa attggtatta tttttagtta acattttact
     9181 atagatttcc ctccgatgtt taaagtattg ttataaacaa tataattttt attatttgaa
     9241 tatttaccat agatccatcg caattttggt aatatgtgtc ttaatgtagt gcatttacaa
     9301 tttatggtta ctgctcatat tgtactgtat tgttaatgaa ctttttcctt tccatttcat
     9361 taaacttaca atagttaata aaaataccac tctttcaagt gtaggataat tttctttaaa
     9421 actgtatatt taactaaaac tataggtata atataaatag acctttaaaa attatataaa
     9481 atatagagtt gcataaatta atcatttggt acgtaaaatt caaataaagt tttgaaaaaa
     9541 gccgtaggct atctataatg tgattaattg attgtttgat agtgaagttc ttaggggtgt
     9601 acaggcatct tttagcgaaa aatatactct aagctctaaa ctatttgcct gtaaaacatg
     9661 aagcaactat cttggcacaa tgcaaattat gatttctagt aatatactag agtataatca
     9721 attcgttgtc ggtatccatt acctactaaa taatatagaa caattccaat gcttttttac
     9781 ttaggtgttc aattgctaca caaaccctta tagattaaac aagccaccag atatactggt
     9841 ggcttggata ctttttacag ttatagacac gcagctgtaa ctgtaactgc tgatgctgtt
     9901 aactcaatac ttataacaga taccaaaaat gacgcaattg ttggggttgt ttgtgcctga
     9961 acatcagaac ctccaatatt agcaagctca tcaagttcgc ttaaatcaac tattcctgct
    10021 ggatcaaatt cttttatcat aatgttttcc cctttcttaa tttagtattt atgttagctt
    10081 tctgttctat gtacacttga acaaaaagtt aatatcatta acaatttgta attatatata
    10141 ttaattgaaa aaccgatata taatgctttt atttattttt cataacgtta aataattctt
    10201 caaatgaatt ataattaaaa tatccattat catgccaata gcatgcttct tggtttttca
    10261 tagtattttt attcataaga cttttttgat agttttcaaa ataaattttt ttataaatat
    10321 tgaaaatttg ttctttaaat ttactaggtg gtagtgagat ttgaccattc aaaacgccag
    10381 caatattatc aatacattta gtaatatgtt tttcttcaaa ttcacgctgt gaaatatatg
    10441 aaatttgatc aataacacct atacctaaat actccatcat tttaagtaaa taatcattta
    10501 caaatatatt gccatttgat gaggatgtag aaattgtcac tccgtatttt ccaaccaatt
    10561 tcattgtgtg taaaaaatgg catatcctat cgaaaaaaat tttcatatcc ccagtaatat
    10621 tatgtgcata tacaggagat ccaaatataa ttaaatcagc atcaagcatg gatttttcca
    10681 acacatccat actatcacta aatgatacac aggagctgca tttagcaaaa cagcctaaac
    10741 agcctgtaca tttatttatc tctaattcag ataaaataaa aaacttacta gagatattaa
    10801 tatttttatt ttctaatcct tctgaaattt tatatgcaat ctcatatgtt ttggaattat
    10861 aacctctagg actaccaatt attgcaacca attttttcat gttttccacc tcatagatta
    10921 caaattttta taatttaatg tatactcata atcactcaaa atgtttgcaa tttctttcta
    10981 ttatatccaa tgataatatt gatggaattt gaggatataa atatcttaac ttagcatagg
    11041 caatgccact acttccaagc ataaatgtat ctaacataaa gttatttttt aatcctaact
    11101 ggatatcact caagttatta attaagcttg tttcaaattt ttttacttca tcattagtaa
    11161 ttatcttatg agtttcatct atattattaa taatttgatt tacaatttct atgtttccat
    11221 aaataccatg acacaagcac atactattca tgttataaaa cccatttgta attataattt
    11281 gtaggtactt aagagtatca tttaacatct tgctgttgtg ctcaattttc aacatttcat
    11341 tacgtactaa tgccattccc gtttctccat tacaccatga tgtcgtaaat tcatctgttt
    11401 ttccattact tgaataaatt aaattttctt tgtttatgag tttagtagct aaatctaaat
    11461 atacacgatc ttttttcaca cggtaaatca taatcaaagc taacgaatat cctgagagcc
    11521 catgagctag tccaatttta tttaagttat tattattaat atatttcaac aaataatcag
    11581 aatatatatc aatgattttt tccattaaat aatttttttc attcaaatag attttagctg
    11641 ccaatactaa tatacctgaa attccacaaa caaaatcata atctaatgat ttatttgatg
    11701 ttttcaaata atcgcaatta tattcaagta tcttattagc aatattggtg aattttaaat
    11761 aatagtcctc attatcataa agaacagaca tattataata taagtacatt aatgacccta
    11821 taccagaaaa tgctgtgagt cttctaaggt tagtttgttt catatcataa tattcatatg
    11881 ttaaaactga agattctaat aatttcattg agatattttc ataattatta ttatcaaata
    11941 attttcctaa gcaagcaaat aaccaaataa ttccgccgcc ttcatatagg ttgaaattta
    12001 tattcgcaag caaaacctga ttattctctg ttgtattaat taaaaatgcg attttatcag
    12061 tctcttttaa atctaaggca ttggaagaaa tagaatttgc aattttcatt attatttctt
    12121 tatttaaatc gctattatta ctacaaaatt tcactctatt aaattcttta ttcataaatt
    12181 tatcttcata tacggtaaat aaagattttt taatgatatc tatttgaaaa ttcttaacat
    12241 tactatttat tttttcaatt cttgtatata aagatttttt tatagtagat tgaaaataat
    12301 ctttatgtat taatatatta tctgacaaca aatcttttga atcatagtaa caataataat
    12361 atggaatatc ccatttaagt aacgtgctaa tttcattgga aatcctctta tgttttaggt
    12421 catctttgca tccattataa agtctttgaa acaactcaac atgtttatct tcattcttca
    12481 aataatctgg atgtgaagct gctatcaaaa atttggcata aacttgagta tgcctaatta
    12541 cttgtctaaa tttctgaaat tcattaaact ctttttcaat caatctaata tatgaatttt
    12601 tattatcaat aattaattct atagcatctt gaaacccttt tataaaatta cttgtatact
    12661 cttcaacttt tacaatttca ctatttaatc taactatatt attatttgaa tatattcttg
    12721 caggttgagt ttctactatc atttcatcag ttttggggtt agctattgcc attgttttga
    12781 gttttgatga tatctgcatc tttccacaca acccacttaa atccatatca aataaattgt
    12841 ttgatgatct attgggaata aatcctgacg ttaaaactga atctatctgc cccggattac
    12901 taataccaac taatgtttct aaatcaatga aatatggatg ttctccatta acaataatat
    12961 tttcaaaatg aatatcattt gtaccaagag tataaaaaat tgctaaaaaa caaccagctc
    13021 tgtaataata attttctact tctatgtaac tcttacattc tccataacta ataaactctt
    13081 gccatccata gttatcataa tcaataactt ttaatgaatt aaggttacat tttagtacat
    13141 cctttgagtt tacccaatcg attatatttt taaaaactat gtcaggtgaa aggctatgcg
    13201 gtttatatac aattttcccg gaatcaaatt ctataatagc aactgatttt ccgccattgt
    13261 gagtatcccc tttacctaaa tggatatcta ttattttttt aaatttcact ttgaattttc
    13321 tttcaagttc aattttatca tttttaaaat taattataat ttcatttaca tataacacag
    13381 tctctcttat tttttgttcc aaaagtaact ttaatacagg atacttttca taaaaatgtg
    13441 tcataaaatg ttcattttca attatttttt caaatgatac aaatctttct ctaggtgttt
    13501 ctcctgttaa taaatttttg tttttataat catgtaactc tttaattaaa gttctaatag
    13561 aatagtttaa tagatttgta taaagataac catatatccc attgaaacta ataatcccac
    13621 ttccctcatt gctaagaaca ctaagtctcg aatcaaattc atttaaatat aatgaaaaaa
    13681 attccggaaa cattctgctt tcttcaggta ttgtatcaaa aaatgaatgc atatttttcc
    13741 ccaccctcac ttttatttaa tcacttaaac tttgagcttt ttttaggttt aatattactt
    13801 ctctaaaaaa taactaacta tctttatcac taatttattt tctaccattt ctacaactaa
    13861 attaataatt cttttataat taacccaatg tgctacaaat attacacgtc ctataactgt
    13921 ttctatatat atcttcttaa aacatcacaa actttttagc ctttccgaca tcaatatgta
    13981 atcttttcaa atatattaca aatttagtat actatataat aattgtgtag tcaatacttt
    14041 tatgttaata ttattacaaa actaataagg ggacttatgt agtagtactt atagttaagt
    14101 actgtcatat ggctgttttt aacgttaata gttgcaataa accatagtta tcaatctaat
    14161 ttataaattg tataaatatc tttaattaac caattatacc taatattaaa ttgttgtata
    14221 tagtattatt atttacttat aggttgtttc gaagttcata taagtaaata tatttgtcaa
    14281 aaagttttat taactttggt ttatcttgtt caaaatactc atcaatatct gtgtaaatgt
    14341 agacaatggg taattgtttt aaatttgatt gcatagaatt ctctccattc gatgaattta
    14401 gttgtgataa atataaatcc gacaaaagtt gaggggattt ctgtatatat aattgtaaag
    14461 acttacaatc acttgattac aatgttatac aattaattaa taatatttta cagggggagg
    14521 aattaaattg ttagaggtaa aaaaacttac taaaaaattt aaaagtttta ctgcagtgga
    14581 tggagtttcg tttgttgcta atggaggaga aatattaggt cttatcggag aaaatggagc
    14641 tgggaaaaca actataatga gaatgcttgc aactatgctt aaggtaacag agggggaagg
    14701 acagatttca ggacatgatt tagtgaagga acctgaaagc attagaggag aaataggcat
    14761 tttatttggt ggagaggttg gcctatatga taggcttaca gcaagagaaa atataatgta
    14821 ttttgccaaa ttgaatggga tgagtgaagg cgatgcaaaa aaaagcatag aagaacttac
    14881 tcgagaactt gaaatgaatg aatttataga taaaagggta ggtaaattct caagaggtat
    14941 gaaacaaaag gtagcaattg caagaagtat tgtccataag ccttccgtta tgttatttga
    15001 tgaaccaagt actggccttg atgtttctgc aacaagactt atccaagact ttatatttaa
    15061 atgtaagtca gaaggtaagg ctatcgtttt ctcaagtcat agtatgacag agattgaaaa
    15121 gctttgtgat agagttgtaa taatacataa gggaaaagtt gtggaacatg gaacaataag
    15181 cgcgcttaag gttaaatata ataatgaaga tatggaagat gtttttgtta atcttattgg
    15241 aggtaatcat gaataaatta gttagtgtaa tattactaaa agaacttaag gatatgctaa
    15301 gagataaaaa gacaataata gttagtttac ttattcctct tttgttaatg ccagtactta
    15361 gttttattat gggaaagact atgaatagtg ctaaggatga tgttaatcaa aataccaaga
    15421 ttgtaatggt ggataagggg catagtagcc ttggtaaaat attaaaaaaa gataagtcta
    15481 taaaatttat aagtggcact gatggaaaag gagcggtaaa ggatggaaag gcactactgt
    15541 ccatcgaaat accaaaggat tttgacgcat ttatttcaaa aggtaataat tctggcataa
    15601 agatttttta cgataataca agtcaaaaat catcaattgc actcagcaag gtaactggta
    15661 taatagatga attaagcaag gaaatagtgg gaagtagatt aacaaaaagg aatatcgata
    15721 taaagatatt aacacctata acagttgcta aaacaagttt tcaaaaggaa gaaaatgcag
    15781 cgggccagat agttttagga atgcttattc ctatatttgt gcttctttat agtgcaacag
    15841 ggactattgc agcagccaca gacctagggg ctggtgagaa ggaacgtgga acacttgaac
    15901 cgcttttaac tacaaaagct ggaagacatt atatattaac aggaaaactt tatgcaataa
    15961 caataatggg ctttatagta tcagtatgtt cgatgattgg tattctagtt tccatgaaaa
    16021 ttcctggtgg gatgttcgga aatggaagta cagcaattgc tctagggtac aaagcaattg
    16081 ccttaattgg agtaatatca ataataacaa caatgttttt tggcgctctt gagctagcgg
    16141 taagtgtata tgctcgttct ttcaaggaag cccaaactta tttgacacca ttttcaattg
    16201 ttcctatatt cgctgtttat ggaactatgt atatggatgc aaaaaacata ccttttcttt
    16261 atttcaacat accactactt agtgtaagct cagtggttaa ggaacttaca agtggaattt
    16321 acaattatgg tcatatagga ataacaatag g
//
