LOCUS       NZ_CP086141            44747 bp    DNA     circular CON 20-JAN-2024
DEFINITION  Clostridium estertheticum strain CF016 plasmid pCF016-270, complete
            sequence.
ACCESSION   NZ_CP086141
VERSION     NZ_CP086141.1
KEYWORDS    RefSeq.
SOURCE      Clostridium estertheticum
  ORGANISM  Clostridium estertheticum
            Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 269589)
  AUTHORS   Wambui,J., Stevens,M.J.A. and Stephan,R.
  TITLE     Clostridia strains as spoilage organisms
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 269589)
  AUTHORS   Wambui,J., Stephan,R. and Stevens,M.J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2021) Institute for Food Safety and Hygiene,
            University of Zurich, Winterthurerstrasse 272, Zurich, Zurich 8057,
            Switzerland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2021
            Assembly Method                   :: unicycler v. 1
            Assembly Name                     :: CF016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Nanopore/Illumina miniseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/20/2024 05:10:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,249
            CDSs (total)                      :: 5,114
            Genes (coding)                    :: 5,019
            CDSs (with protein)               :: 5,019
            Genes (RNA)                       :: 135
            rRNAs                             :: 15, 14, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 14, 13 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 22 of 95
            Pseudo Genes (incomplete)         :: 78 of 95
            Pseudo Genes (internal stop)      :: 14 of 95
            Pseudo Genes (multiple problems)  :: 16 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:27:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 150028
            Orig. end                         :: 194775
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086141.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..44747
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..44747
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="chemical_hybrid"
                     /product="lanthipeptide-class-i"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..35254
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:25254]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..25254
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(726..977)
                     /locus_tag="LL065_RS24685"
                     /old_locus_tag="LL065_24665"
     CDS             complement(726..977)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013842739.1"
                     /locus_tag="LL065_RS24685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24665"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_226139629.1"
                     /transl_table=11
                     /translation="MKQCIACGMPMKSPEDFAMGDSENEYCVYCCRPDGTMQSYDEKLN
                     SLTNFIVKTQGLDAKAANSAAKSMMAKLPAWQTESAIL"
     gene            complement(1002..1541)
                     /locus_tag="LL065_RS24690"
                     /old_locus_tag="LL065_24670"
     CDS             complement(1002..1541)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004624589.1"
                     /locus_tag="LL065_RS24690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24670"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_253203771.1"
                     /transl_table=11
                     /translation="MIEIAIKQFGENGIITTPTADIAKAAKVSHGTVFAHFSTQEELLI
                     SVIEEFGNRITQRLHELVDTNSSLFEVLEAHIEGLIEFEPFYTRLIIERRLLPESVRNT
                     YIMIQSTISFHISIAAEKEIKQGTIRKVPIHLIYNTWIGLIHYYITNGDLFSPNGSVLK
                     QYRHELLQHYINLITK"
     gene            2390..2797
                     /locus_tag="LL065_RS24695"
                     /old_locus_tag="LL065_24680"
     CDS             2390..2797
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024803.4"
                     /locus_tag="LL065_RS24695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24680"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_226139628.1"
                     /transl_table=11
                     /translation="MYTIGQVAEITGISRDRLRYYEEKGILKPKYDTSNNYREYGWWDL
                     DIVLTIEFYRSMNLSTKSINNICENSSVKSIKQLMEKKYEEVASDITKLQKIQEKVGNI
                     IKQCANIGGCVVMEQKTGIRTEDNGIYLFLI"
     misc_feature    2410..2426
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.88"
                     /tool="antismash"
     gene            complement(2822..3397)
                     /locus_tag="LL065_RS24700"
                     /old_locus_tag="LL065_24685"
     CDS             complement(2822..3397)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004458491.1"
                     /locus_tag="LL065_RS24700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24685"
                     /product="recombinase family protein"
                     /protein_id="WP_226141345.1"
                     /transl_table=11
                     /translation="MIIGYARVSTKGQLKEGHSIEVQTRNILDRYDDAEIRVEQYTGIT
                     MDRPIFNKLIEDLKQGDTLVVTKLDRLARNTVEGISIVQDLFNKGISVHVINIGLLENT
                     SMGKFFLTTLLAVAEMERNTIIERTQTGKAIAKTKEGFKEGRPKLYTSKQINNAIEMLK
                     NNSYTEVTEITRISKSTLIREVRKRKVK"
     gene            complement(3619..4365)
                     /locus_tag="LL065_RS24705"
                     /old_locus_tag="LL065_24690"
     CDS             complement(3619..4365)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-120). E-value:
                     5.3e-13. Score: 41.1. Matches aSDomain:
                     nrpspksdomains_LL065_RS24705_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003493792.1"
                     /locus_tag="LL065_RS24705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24690"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_226141343.1"
                     /sec_met_domain="PF00561 (E-value: 4.9e-10, bitscore: 33.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFKYENINIYYKVSGEGRPLVIIHGDTASSKMFIPELRFYSKN
                     FKVILLDLVGQGKSQRVDKLPLNYWHFNSTLIIELCKHIGISDVNLLGTSGGAIVALNA
                     VLKQPNLFNRIVVDSFMGENLSYEFAKKIVDDRKIAKNKVGSKLFWFIMHGFDWENVID
                     QNTSLIIDFSRNIGNFFNYELSNIENNVLITGSSKDDLIPNVQSTLKAINLKMKNSKLV
                     IFENGNHPAMFSNKKEFRNLVLEFLS"
     aSDomain        complement(4006..4305)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LL065_RS24705_Abhydrolase_1.1"
                     /evalue="5.30E-13"
                     /label="LL065_RS24705_Abhydrolase_1.1"
                     /locus_tag="LL065_RS24705"
                     /protein_end="120"
                     /protein_start="20"
                     /score="41.1"
                     /tool="antismash"
                     /translation="PLVIIHGDTASSKMFIPELRFYSKNFKVILLDLVGQGKSQRVDKL
                     PLNYWHFNSTLIIELCKHIGISDVNLLGTSGGAIVALNAVLKQPNLFNRIVVDSF"
     gene            complement(4683..7691)
                     /locus_tag="LL065_RS24710"
                     /old_locus_tag="LL065_24695"
     CDS             complement(4683..7691)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001143746.1"
                     /locus_tag="LL065_RS24710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24695"
                     /product="Tn3 family transposase"
                     /protein_id="WP_268064750.1"
                     /transl_table=11
                     /translation="MPVEFLTKEQRNRYGNFIDEPTNEQLAVYFLLDDTDKKAAHSHRG
                     DYNRIGFAIQLGTVRFLGTFLPNPLKIPSNIIHYISQQLELSENNLEKYSYSESRWDHT
                     REIRQAYGYHDFMMQPHHFRLVRWLYNHFWLAPERPSVVFDLTMARLIEQKILLPGATV
                     LERLISQIRERATSRLWHKLASLADVNQRETLENLLIIDAKNKTGLEMLRQAVTHESPI
                     GFLKAIKRFKMIYSIGAYQWNISRIPIGRISVLSRYASIARSQTIKRMPDERRIATLVA
                     FAITYTTSSQDDIIDYMERYFSTLFNGANRKGEKERLRSLKDLDSSARELSKACLLLLD
                     ETVPDETIRKIIFSNIPKERLKLAIGMIDTITRPIDQTVEYKELFRYYTSIRRFLPALL
                     ATIKFRASAAGQPALAAWDFLSKVESKTGKNKFSDAPTDGISASWKRVVFKGDSISSCP
                     YTFWAIEKMLEGIKNYDIYLKKSDRYNDPRSNLLQGSAWKSVKSKVLSTLGWSSNAEES
                     LNPLKKNLDTTFKNTIKNWDDNPDVRVEMVKGKEKIVLSLINRLEEPKSLILLKKQVES
                     LMPNTDLPGLLMEINALTRFTDQFTHISQGNSRIKDLSVSICAIFIAKACNIGLGPVVQ
                     PGIPALEYDRLTWVEQNYFRTETITQANAVLADHISKMTLAKSWGGGEVASADGIRFVV
                     PPKTIYAGPNPRYFGIGRGITSYDLISDQFAGLNKLVITGTIRDSLYLLELVLGQQTTS
                     NPREIMTDTAGYSDIIFGVFALLGYRFSPRLADIGSTRLWRFDPNADYGVLNSLSKHKL
                     REDLIIKSWDDMLRVAGSLKLGTINPTNLIKMLQRGGKPTMLGRAMGEFGRIFKTTYEL
                     SFLDDKNYRRRILTQLNRGESENGLKRVVVYGKKGEIHQPHREDQEDQLNTLGLVTNAI
                     ILWNTVYMEKALDAIRNAGYIVNLDDVKRLSPLGYDHINIVGHYSFDLAKKILSGKLRP
                     LQPMNKKLFGKKR"
     gene            7940..8395
                     /locus_tag="LL065_RS24715"
                     /old_locus_tag="LL065_24700"
     CDS             7940..8395
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="LL065_RS24715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24700"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_226139909.1"
                     /transl_table=11
                     /translation="MCLYRFSVPLLHNPRLRERIGIVSQSIFLFKGTVLANILYGQTRK
                     KLEDVEKLIKKLGLQEYINRLPNGLSTEITQNNSGISGGQAQVIAFIRVILSNKDVIIL
                     DEPISNVDTETRDLILGILRDKDFEGMLIVVSHVIEGMDFLNRVIEI"
     gene            9626..9805
                     /locus_tag="LL065_RS24720"
                     /old_locus_tag="LL065_24705"
     CDS             9626..9805
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS24720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_24705"
                     /product="hypothetical protein"
                     /protein_id="WP_226139759.1"
                     /transl_table=11
                     /translation="MIKMANFDDFDLDININKASAKVSQSFPTQSGGFNTNTISICSVP
                     CTFPITTITVACTK"
     CDS_motif       9626..9712
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIKMANFDDFDLDININKASAKVSQSFPT"
                     /locus_tag="LL065_RS24720_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9713..9805
                     /prepeptide="core"
                     /locus_tag="LL065_RS24720_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="1.90"
                     /molecular_weight="2925.4"
                     /monoisotopic_mass="2923.5"
                     /core_sequence="QSGGFNTNTISICSVPCTFPITTITVACTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIKMANFDDFDLDININKASAKVSQSFPT"
                     /leader_location="[9625:9712](+)"
                     /alternative_weights="2943.4"
                     /alternative_weights="2961.4"
                     /alternative_weights="2979.4"
                     /alternative_weights="2997.4"
                     /alternative_weights="3015.5"
                     /alternative_weights="3033.5"
                     /alternative_weights="3051.5"
     gene            10001..13156
                     /locus_tag="LL065_RS24725"
                     /old_locus_tag="LL065_24710"
     CDS             10001..13156
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014194788.1"
                     /locus_tag="LL065_RS24725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24710"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_226139760.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-134, bitscore:
                     444.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4e-16,
                     bitscore: 53.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.8e-37, bitscore:
                     122.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNLYKNVNTFMIRTPLKPIDKYFEFFNNNVDGEKTKEYVKELC
                     NDPVFRESILISSKSLYDTIINFINGKDIKKQEYFFRSIYKYLIRMSTRPTPFGLVSGV
                     CFGNYSDKTSIIYEDNQFKKFARSDLEWIMGLVKVLEDKYYQSLMYKINGYILIKGDRA
                     VLPHSTLKEDNDSVTDISIRATDAFKVAYEGAQTTISYSQLKNKLLIKYPEVLEDKINF
                     FLKELIDKEYLISNLRPPLTVIDQFDYLIKEIQRCDINKIILDQLTNIQKKINIYNKTY
                     VGEGESIYIELCKDMNNMEKCKTPLQVDMKLNMKEKTINSKIIDDLNELIHLLLLVSPS
                     SHNSQDYFQIHKMDFMEKYGQEREILLLEMIDNDLGIGAPATYVHPKNNRSKTFNSSDL
                     VNKKVKSYLLQKYIYALDNNYNSIEINDDEIKALDLPQYNYEEIPNSLELNVIVRAESK
                     EELKKQNLNYHIGPNVGSPQAGKAFGRFSHLMNSPEKFFSELNDNNKTLIDSDEFIHCE
                     LVYLGSKLRSANVTRNIHCNEYEIALFTNTSKSDEYSLTLDDILIGIEDNVFYAKSKKL
                     NKKLFITVNNMLNSSMAPNAVRFLYDISLDGGKKWFDFPWNYAFYEFPYVPNIKYKNIT
                     ISQEKWILDSINVKGDKKLGFDKFKDSFKLYCSSYKVPQYVYITFADNRILLNLEDNKC
                     LEILYHEFTNNLGDTITLNAYEEEPYNIVTGNDGNYFCELIVPLIKVKSHHPKDIQISN
                     KSSDIPSISPTRLKLPFDDWLYFKLYGTSSSDDKLIAFFISEYFHDLVHSQKIEKYFFM
                     RYVDPEQHIRLRINAKQSNLLDIYPNLQQWFRSLIEKGIITHIAIDSYDREIERYGGSN
                     LIDTAENVFYADSIVTEDILKEKKFNNLTLSDELIGMISIIQYMDQFGLDYDNQCDFLE
                     SLVEKTDYREIFKKQRSEFMKLCNSNDNWNGLRQHQEGKLLLNIFNNRTESIQIYSSEI
                     RKRNNNSLMSEWSILNSIIHLHCNRLFGINREFEKKILTLTRHTLHALRYFKKGSEVKN
                     LVN"
     aSDomain        10469..10720
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LL065_RS24725_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.90E-17"
                     /identifier="RREFam001.1"
                     /label="LL065_RS24725"
                     /locus_tag="LL065_RS24725"
                     /protein_end="240"
                     /protein_start="156"
                     /score="53.7"
                     /tool="antismash"
                     /translation="LIKGDRAVLPHSTLKEDNDSVTDISIRATDAFKVAYEGAQTTISY
                     SQLKNKLLIKYPEVLEDKINFFLKELIDKEYLISNLRPP"
     protocluster    12438..44747
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[22437:34747]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      22438..34747
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
     gene            13501..14823
                     /locus_tag="LL065_RS24730"
                     /old_locus_tag="LL065_24715"
     CDS             13501..14823
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008429197.1"
                     /locus_tag="LL065_RS24730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24715"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_226139761.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-74, bitscore:
                     245.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIILKKSIDNLVKDIAKKLQSFDFLQKMINDKNNYININDLEINP
                     YDAMALSKGVPSLCMLYGEMNEQYPKEDWDIVDHQYIKILGDMITENGIEELSMFSGAA
                     GIGLSIVCSSKQRERYVSFISNINEFIKSNIKEFMDKIKANPYCNITNYDVISGVSGIA
                     SYCMLFPQDDGMTDILKEIVTYIIDICRDKNIENISVPGWYIPSENLFTENDKQQWPKG
                     CFNIGLAHGIPGILIILCNALKLGICLDGQSDCITKIGDFLIRFRKQDNNGCYWGCIVS
                     LDEYIDDTMDDPYFRDAWCYGTPGVAYSLLLAGKVLNNESYITSAIEGMQSSIKRLKEI
                     YSPTFCHGLSGEIYIAYRFYELTNLVEFKDAYIELSNKLISFYDAEAPFGFYDIEIANG
                     KCKNYNYIGLIDGTVGILLTLMAIQNGKKTPWDCAFLLADI"
     gene            15148..15510
                     /locus_tag="LL065_RS24735"
                     /old_locus_tag="LL065_24720"
     CDS             15148..15510
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS24735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_24720"
                     /product="hypothetical protein"
                     /protein_id="WP_226139762.1"
                     /transl_table=11
                     /translation="MLKKIPIFSLLLILMVVVTLTTTSSTKVRAATLNSGFVSSKYIVI
                     NDRLSLLSFGSSSGTVKLDASISALNVMDSSSLSGNIKDSLADGYTVTVLSPVNRFLPP
                     VFQPVLPLFYHIVYLK"
     gene            16066..17109
                     /locus_tag="LL065_RS24740"
                     /old_locus_tag="LL065_24725"
     CDS             16066..17109
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025079.4"
                     /locus_tag="LL065_RS24740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24725"
                     /product="DUF4158 domain-containing protein"
                     /protein_id="WP_226139763.1"
                     /transl_table=11
                     /translation="MESNNKIDESFKFSEIEIDIVHNNRKAETKIGFAVLYKFFQNNGR
                     FPYDKFEISNEVICYISEQIGVDSSCYNDYDWNGKSIINHRKQIRELFLFRECTVQDYD
                     TIKIWILSNVLPKNDDSELVKKEVYKQFKELKIEPTTPERIERIVSSAINTYENNIFES
                     IFNKLPVETILKFDLFLVTESENNNMEQIIWFNDFNIDPDGANIKSVFNESNKLKTIEG
                     MMMPEDIFKDIPSKLLKKYYKRSKAENISEFKRYPDALRNGLLAIFFHFKSMEIKDNLV
                     DLLIKILNNLDTSANRKIKKELAESTNYTRNKNKLLLKIAKAVVESPEAKTCDLHIKGI
                     IGVFCRI"
     gene            17061..17423
                     /locus_tag="LL065_RS24745"
                     /old_locus_tag="LL065_24730"
     CDS             17061..17423
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS24745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_24730"
                     /product="hypothetical protein"
                     /protein_id="WP_226139764.1"
                     /transl_table=11
                     /translation="MRSSYQRHYRRILPDIINALNFNSNNDKYKPIIKAIELIKKYLAS
                     KSRCYLRDEIVPLEGVVRPMWKEMIEDKSGKNNELRIKRANYELCALQALKDKIRCREV
                     WISGADKYRNPDEDTT"
     gene            17477..18562
                     /locus_tag="LL065_RS24750"
                     /old_locus_tag="LL065_24735"
     CDS             17477..18562
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013676.4"
                     /locus_tag="LL065_RS24750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24735"
                     /product="transposase"
                     /protein_id="WP_226139765.1"
                     /transl_table=11
                     /translation="MKDSLSKLNKTIPKNEKVKILDIGNGRIKISPSPKQPEAKNLLKL
                     KREISNRWPDLNLLDVFKEADLRIDFTKHLKTSATQERLTRDIIRKRLLVSLYGMGTNM
                     GLKAVSSKGLDENYMDLEYIKRKFINKDNLRAAIAEVVNATLKIRSQNIWGSATTTCAS
                     DSKKFGAWDQNLRAEWHNRYHGRGIMIYWHVEKKSLCVYSQVKSCSSSEVASAIEGVLR
                     HCTDMSIEKNYVDTHGQSEVAFAFSCLLGFKLMPRIKNINKQKLYKPEISDADYSNIEL
                     VMKKKPINWELIRQQYDQMVKYATALRLGTADAESILKKFTKNNLQHPTYQALSELERA
                     IKTIFICRYVMSEEMRIEINL"
     gene            18631..19344
                     /locus_tag="LL065_RS24755"
                     /old_locus_tag="LL065_24740"
     CDS             18631..19344
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017313963.1"
                     /locus_tag="LL065_RS24755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24740"
                     /product="site-specific integrase"
                     /protein_id="WP_226139766.1"
                     /transl_table=11
                     /translation="MPAELQRTSPKKKAKEITKYLRKERPDYNYLKSLFKYLREELEIE
                     IPRNARKLPYVPTEDEIKNYYKVVWNSKNFQDMLIIKVLIYTGVRVSELVSIKISDIDL
                     FNCQIRINQGKGNKDRVVPFPEGFKEVLGIHCNNNLKNTATYLFESSWKKKYTDRGIRK
                     ILEKYSVQAGLKTMISPHKLRHFLFTWLKKQGIDDALIQPYSGHESRKTLEIYSKLSIA
                     EAQEAYDEVINNFPI"
     gene            complement(19921..20622)
                     /locus_tag="LL065_RS24760"
                     /old_locus_tag="LL065_24745"
     CDS             complement(19921..20622)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="LL065_RS24760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24745"
                     /product="ABC transporter permease"
                     /protein_id="WP_226139767.1"
                     /transl_table=11
                     /translation="MLRAELYKYFKNHLFSITLILPIILVVGIIYLAPTLNNSNTFDNG
                     LLKYIVFRNFFYIIMVPLYIMIICRIVGEMEQKNNNWILLMSMPLKKNKIYFIKMFTLT
                     GMVSVHYLGYLIGILLVKVISSNFQIAFQSILLDLLLSFLCTFSIISFFYIFSLEKILL
                     IVYLGIGIVMVLSGFLASQSEHQWVYCPLSYPFVVPSLSTGVPKFIFINVALTIVFHLI
                     GFIRFRKREWV"
     gene            complement(20637..21383)
                     /locus_tag="LL065_RS24765"
                     /old_locus_tag="LL065_24750"
     CDS             complement(20637..21383)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="LL065_RS24765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24750"
                     /product="ABC transporter permease"
                     /protein_id="WP_226139769.1"
                     /transl_table=11
                     /translation="MLIKLLHCEEIKLKRTWIFVMSILIPFAINFLLTIDLHYRYTGYL
                     LVHQERMNLSCWQLIFKEQRVLYFPALIPFFATLILIHVFSTETKNNGWSMLLTQPIKK
                     SKFIIAKYIVSCKYITILIFFNIISITISGVITGVKDPLDIDLFIRCFLILWSSALATS
                     AIQMIVLNIFSLKWISLFLAFLLGSISQDTYLKGIIGKFNPYSFADYSFRANWNQTVFI
                     LIISCVFIIFGLLVSTLIFNRKNIYR"
     gene            complement(21529..22422)
                     /locus_tag="LL065_RS24770"
                     /old_locus_tag="LL065_24755"
     CDS             complement(21529..22422)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014519826.1"
                     /locus_tag="LL065_RS24770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24755"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_226139770.1"
                     /transl_table=11
                     /translation="MSDIVVNTNNLQKSFNKKIVVENLCLRIPKGCIFGLLGPNGVGKT
                     TTIRMLLGLIYPDNGTIEIFGKDISSNRESILKDIGAMVESPSFYGNLNAWENLKIVCL
                     MKQINTEHINATLELVGLKDCAKKKVSNFSLGMKQRLGIATAIIGNPKLIILDEPVNGL
                     DPSGIHEIRTLIKSLAKNSQITFLISSHLLNEMELMADKVGIIKNGHLIYQGDLQQLMD
                     THDRRITLGVTELKKAIEYFSSINIPVINQDNNLVIEGNYTVEYISKKLMEQGIGITSI
                     DDKTNSLEDIYLKMMN"
     gene            complement(22438..25254)
                     /locus_tag="LL065_RS24775"
                     /old_locus_tag="LL065_24760"
     CDS             complement(22438..25254)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="LL065_RS24775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24760"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_226139772.1"
                     /sec_met_domain="DUF4135 (E-value: 7.6e-80, bitscore:
                     263.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.5e-58, bitscore:
                     190.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRENIIQNKYLSNWESSDTVNSICNDLSTAFGNFHKTFLSYCEL
                     HIEIALEKFLFKYSFEIDKHTIMCSLLINIAEEITGLSIRTLIVELNTLKSNNQLEGEN
                     SIDRYNYFNQKLIDELYLEEIFSKYPVLLYLIDTKITDRLILIDEILERLGQDKQDIES
                     KFNMNVHNLININISSGDSHNNGKKVTILQFGEKYIVYKPHGLSPESLFNEIIDYLNKK
                     VTFEYDLKKLECIDRTNYGWQEYAVYSEAKNSSDTYKFYYRTGVFLSIFYMFSCSDLHY
                     ENVLACKDTPAIFDLETLINIFSQTLQTNTVTSEINREISVSVFGTMLLPVNFSTGCFD
                     FDLSGMAGNDDTVSNKWFYYHIENLGTDNILLCKEACTSPKTKNSLIFNNEIVSPKLNF
                     SSMKNGFSTCYSALEEISDEILNIVNKSMLIIRHVLRPTAVYARFLESSTYPKYLESME
                     AMQNLFSKIHNSSFNNDIVECEINALMKHDVPYFSSYINSETIIGNEHKNILNYFPKSA
                     YNVIEDKLKAFNKNDLNKQLYYISQSLSSIKGSVTNYMYNYELKEKDSYLSNAKLIADQ
                     IYNLSVFNSDQSEASFIMTFGPSDTKKNIDTMDFNLYTGGGIILFLALLGTELKEQKYV
                     RLAEQFLKFQLSKTDSLISLSAFSGIGSKIYICYNMYKITNNKLYYKKIHELLLEINVA
                     ENCSKDFATGTAGLIVVLLNIFEKEQDKIWLEKAELLGRDLYKSLIEEHDNLLTGLAHG
                     LSGYAWALIKLGIATNKQEYIGFGMKLIQKENMYYVPSEYNWADLREENQYLSYWCYGA
                     AGISLSRVKIQNLLNDDNNIVTNNLLNGIENTKKHKCKSSSICHGTFGNIDILLEIGKI
                     KKMDSLISLAKDFANTELSYIQNNGITLGDDSYLIDYSFMQGISGIGYSLVRLANNNYP
                     SILSLDVM"
     misc_feature    25401..25416
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.88"
                     /tool="antismash"
     misc_feature    25455..25471
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.66"
                     /tool="antismash"
     gene            complement(25502..25699)
                     /locus_tag="LL065_RS24780"
                     /old_locus_tag="LL065_24765"
     CDS             complement(25502..25699)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="LL065_RS24780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24765"
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_226139773.1"
                     /transl_table=11
                     /translation="MIKNNEICKNAGFISEDELVELVDSSDINGGTTPVVSAISATVAS
                     ATAVSALFTVTSACTKSCNK"
     CDS_motif       complement(25595..25699)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MIKNNEICKNAGFISEDELVELVDSSDINGGTTPV"
                     /locus_tag="LL065_RS24780_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(25502..25594)
                     /prepeptide="core"
                     /locus_tag="LL065_RS24780_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-12.70"
                     /molecular_weight="2692.1"
                     /monoisotopic_mass="2690.5"
                     /core_sequence="VSAISATVASATAVSALFTVTSACTKSCNK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIKNNEICKNAGFISEDELVELVDSSDINGGTTPV"
                     /leader_location="[25594:25699](-)"
                     /alternative_weights="2710.1"
                     /alternative_weights="2728.1"
                     /alternative_weights="2746.1"
                     /alternative_weights="2764.1"
                     /alternative_weights="2782.2"
                     /alternative_weights="2800.2"
                     /alternative_weights="2818.2"
                     /alternative_weights="2836.2"
                     /alternative_weights="2854.2"
     gene            26022..26513
                     /locus_tag="LL065_RS24785"
                     /old_locus_tag="LL065_24770"
     CDS             26022..26513
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS24785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_24770"
                     /product="hypothetical protein"
                     /protein_id="WP_226139774.1"
                     /transl_table=11
                     /translation="MGSNLFREASFKKMLKPEEDNITDYVKNIHAKTWVILLAIFILLV
                     SIPFWVFTVTLPNKIELIGVSKKNQLVIYLSPESCKSLTMDSTVKIDNTYDAKISTISS
                     IPLSKSEVKSTLKLDYYKSNITLSDWNMVVTITCNTNSIKDDKLYNVTITNGYIDLINY
                     "
     gene            26538..28682
                     /locus_tag="LL065_RS24790"
                     /old_locus_tag="LL065_24775"
     CDS             26538..28682
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014519819.1"
                     /locus_tag="LL065_RS24790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24775"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_226139776.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.5e-37, bitscore:
                     120.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFYKSYVKVPVVMQLENVECGAVCLTMILAHYGKWVPLDQVREEC
                     GVSRDGCNLNNMTLAARKYGLEVHNYSCGLNHIMTKAKSPCIIHWHFNHFVVLNGFTKK
                     GAMVTDPAQGRVTIPIEEFSEGFTGVYMEFNKTSQFVADGKRQSIWMFIRNRLGNSIFT
                     LSFILLTSVITCIIALIYPVLGRLFIDYILSKSNPYWLYKLISVMLLLLLSQIIVAVIT
                     GITSLKIQGKYAIHADYSFIKHVFRLPLSFFSNHMAGDISVRQDSNRTIAYTLIQMLTP
                     TFLNLVLLITYFFIMIQYSVPLTVIVVSITCINSVLAIIISTKRLEISRVQARNIGNLT
                     STTLTGLQMIESIKANGSESGFYKIWSGNQAAVNNTNVKLDEISISWGMIPQFIDKLGN
                     SIILTLGAFYIMKNHFTVGMLLAFQGFMAAFIKPVNSFISTGQNIQEMRSSMERIEDIM
                     QAKTDSFYTIDSSCKTESFEYLELSNVSFGYSKYSNPVIAGFSLKIQSGTSIAIVGTSG
                     CGKSTLSKLVSGLFEPWSGEISYFDNSLNKIPSNEFRKLLAVVDQNIVLFEDTIENNIK
                     LWDSSITDEQMYAATKDAQIHSTIMERGNGYQGVLLENGNNLSGGQRQCIEIARVLAQN
                     PKVIIFDEATSALDAATEYKVMQSIRSRNITLIIISHRLSIVRDCDEIIVMDNGKISER
                     GTHNELFKQNKMYKKFVTTE"
     gene            28692..30836
                     /locus_tag="LL065_RS24795"
                     /old_locus_tag="LL065_24780"
     CDS             28692..30836
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="LL065_RS24795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24780"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_226139781.1"
                     /transl_table=11
                     /translation="MNKYINNEKPLNDFDSGIPIKETNLKKQNKIALTLILKYYKVSSL
                     TDTCMQSDNIEHMMINLIPEKGLIYRSIILKSDWYKNSMGVMIGKMRTGETVVFIPKTV
                     SGYAYINCKTKKICKVTKKSSELFEFKAFSFNKILPKVSLSISDFFKYTLKAVPSQKYI
                     MLFLSYLVVTLLGLMLPYINQYIFSDIISNSSYKALLSLTYVLVGIVIVTTLFTIISRS
                     VVYNIRTTISVTTQNALIDRILSLPVSFFKEYSSGDITKRLQGFISVISQMIDTILITV
                     LTVLFSLIYIIQIIKMTPTLAIPTSIITLLMLAFIVVFIIMQIHVYIKLNENDVKVSST
                     FFSLLFGIQKIKLARAEERAFNYWDKKYKKSAELLYNPPFILKIQPHFSLMASYVTTII
                     LYYIAATANISVASFMSFTVAFGMVIAALTSLSDISIVFAQFYSTVKLLSPILRSIPDS
                     DDNKQITKKILGTVELKNVCFKYSLQNKNVFEDFSLKIPSGQYIAITGPTGCGKSTLLR
                     LLLGFEISQSGSVTYDNVNIKDMNIRNFRKQVGTVLQDGKLFLGSISENITFFEPHLTI
                     EDAWKAAEIAGIADDIRNMPMAMFTVISEGDGSISGGQKQRILIARAIASQPKILILDE
                     ATSSLDNITQENLIHSLEKLNCTKIIVAHRLSTIQLCDKIIMVNNGQIIEEGTYESLID
                     KNGMFYDFVLRQQASVLVPD"
     misc_feature    complement(31137..31155)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.14"
                     /tool="antismash"
     gene            31333..31560
                     /locus_tag="LL065_RS24800"
                     /old_locus_tag="LL065_24785"
     CDS             31333..31560
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009985587.1"
                     /locus_tag="LL065_RS24800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24785"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_226139783.1"
                     /sec_met_domain="mature_ha (E-value: 2.9e-09, bitscore:
                     30.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKNPIMRTKLHQIEEFPCGDLFEEINENSMTMDAVNGGGWVSTI
                     LQGTVGCLASYALGNQGKICTWSVECQNNC"
     CDS_motif       31333..31449
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MIKNPIMRTKLHQIEEFPCGDLFEEINENSMTMDAVNGG"
                     /locus_tag="LL065_RS24800_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       31450..31560
                     /prepeptide="core"
                     /locus_tag="LL065_RS24800_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.40"
                     /molecular_weight="3697.2"
                     /monoisotopic_mass="3694.8"
                     /core_sequence="GWVSTILQGTVGCLASYALGNQGKICTWSVECQNNC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIKNPIMRTKLHQIEEFPCGDLFEEINENSMTMDAVNGG"
                     /leader_location="[31332:31449](+)"
                     /alternative_weights="3715.2"
                     /alternative_weights="3733.2"
     gene            31664..34747
                     /locus_tag="LL065_RS24805"
                     /old_locus_tag="LL065_24790"
     CDS             31664..34747
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="LL065_RS24805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24790"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_226139785.1"
                     /sec_met_domain="DUF4135 (E-value: 5.1e-94, bitscore:
                     309.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.5e-61, bitscore:
                     202.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNINVDYCDTDIINYWLMLFPELKNAEKLDSYLKENLGSDLKQN
                     INKLKEYSNTDKKAFDYINLDCTNLKKIMNDSSINIRFFNFYGVFIAKHIKKITDVIYE
                     ADMMIYSTDKFLKSIVSQASARLYELSLRTLILEINVARENGILKGDSSEEKFYYFENV
                     LLKDETYRKNLYQEYSTLVELLDETMNDFISYICEILIRTKDKIGMIEEKVNNNQKLGK
                     IVDIQLSLGDSHCNGKSVAKIILENNKIIYKPRSLNSDINFQKILNLMNSKKFLVDCTF
                     KLINMYSTDNCGWMEFVEYTKCNTLDESKRYYKRAGSLLVILYALNAVDFHFENMIACG
                     EYPMLIDLESLFHTGLRNLETEKESGYTKAIEHIQSSVLSVGLLPSILAIGKAGEKHSI
                     NVGGLSEGVEQLSPLKSIVVGNDYSDKIKVQFKNRIMDPKENNPTYNGKQIDPAKYLDD
                     ILSGFETTYKWILENVEEFKQFTIKLFVQTRNRVIIRPTFIYSQLLNIATHPDFMREKV
                     HRDLLLSRVAIESKNNDLIEFELEIMKKHDIPFFVADFMSNTIFDFNGNCIKNKLEIVP
                     LNGFYNKLDNLSLEDLKNQKEMIFNSYFDKDVEYERTNVELDYYPEIININKWVDTAKK
                     IGDYLIDSSIVGSNLRGNLDRFWIGSCVERMDSGDWTHGVLDLDLYDGNSGIALFLLYL
                     GINTNNDKYVNAAFEAIEPIITIIENKSFNYNKFTGVYKGVSGYYYVLNKFACLCKRSD
                     LSDLLNNSINTFEELIDEDIVLDLIGGSVGVIATMVSIYNSTTNEKLKQNSLKVAYRAF
                     EHIEKNILNNENVSTMLYEDKVKYSGYAHGIAGILVNLYKLYLIVKDERIIKLFKLLLE
                     YEREDFKIEKENEWRISTDNNDTAKGWCHGSPGILLEKVILKKLGYYDSKIDAELEGAL
                     YSTINLGIGNNVSYCHGDLGNISILLYYSKIYNDKNLEQKCLSTFQNIYSNHLENGWHD
                     EKKSFSKFKGLMLGISGVGFSLLKNSYSSTIDDFLWID"
     gene            34853..37006
                     /locus_tag="LL065_RS24810"
                     /old_locus_tag="LL065_24795"
     CDS             34853..37006
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009985592.1"
                     /locus_tag="LL065_RS24810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24795"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_226139787.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5e-36, bitscore:
                     117.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNKRHVPIIKQLTQTECGLCCCVMILRYYKSNESLKELQDYMDV
                     GRDGLSISQIKNLFELKGFKGRIFKVEKAEALCSITKPFIAYWKKSHYVVVEKFKKNKF
                     YIKDPAEGTKVISLEEFEKDFSNIIIVAEVTENYKPQKKKKYKPWKDAFASLLEHKLLI
                     FQLLPLLIVTYILTLQIPILIQKIVDKTMVSTNMSYLNIFLLVIFIAIGLFLVSTLVKG
                     VKLISLNIILGRSLEADTYKHLLKLNYKFFEMRSTGDLLFRLSSTSAVKELLSSQIISG
                     ILDIGTIIVIFVYMLKQSVLLTFAALVVFILNLIFMLIVQPIFTQAMNDELTEKSKSQA
                     LQVEALYSISSIKIACIEDDVYAIWKDCYERVIKMVKKRMNINNYSGSITSTIQQFVPI
                     IILIIGISEYFKGIMSIGEVIAFETIVSTFFALSTSIFNNYTQYLLASEYLERVTDIWY
                     SKEDEEGENIVEKKISGCIKLDNISFSYSKNSPKVLKNISLDIEAGKKIAFVGASGSGK
                     STLSKIIIGLYESTEGELLYDNIPFKMYNKKKLCSQMGIVPQDAMLFNKSIYDNIVMNK
                     KNLSLEEVKKVAKIARIDEEIELMPMAYNTIVSEMGMNLSGGQRQRILLARALINKPKI
                     LVLDEATSSLDNINEEAISEYLSKQGCTRIIISHRLSTIIDSDIIYVFSEGEIVESDTH
                     YNLMKKKQGIYCKLYTSGIKVQV"
     misc_feature    37440..37456
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.21"
                     /tool="antismash"
     gene            37935..38693
                     /locus_tag="LL065_RS24815"
                     /old_locus_tag="LL065_24800"
     CDS             37935..38693
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014573.4"
                     /locus_tag="LL065_RS24815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24800"
                     /product="flavodoxin family protein"
                     /protein_id="WP_226139810.1"
                     /transl_table=11
                     /translation="MVKKIFAYIGSPKGKNSYTWKLTKTILDQVISLSDGEIHYKLILP
                     DQIKINFCVGCKCCFENGFCPQDTSDSMESIKEEMLQSDLIILASPVYAHNVTGNMKVF
                     IDRITYWMHIFGLAGKFGVTISTSDSNGNEYVNSYLNKIMQYCGLNVICHFKAMQMINP
                     LTTNNTFSNLDTMPLSRLICDYLTNNHQMSATSFQETIFQTFKNYMLTLEENNIQSSEV
                     KYWKEHGYFDADSYDTVLSKLQEENYKILD"
     gene            39419..40273
                     /locus_tag="LL065_RS24820"
                     /old_locus_tag="LL065_24805"
     CDS             39419..40273
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS24820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_24805"
                     /product="hypothetical protein"
                     /protein_id="WP_268064751.1"
                     /transl_table=11
                     /translation="MISLHSKGLKLRDELNVKSSKSANEIMQIHVKLVKAIDTALSEKK
                     DISKELENLGKWEIFKETAYSAEKIIRPLNNDYLDLLDSSFGNLRKYSPILFKNLEFHP
                     SNNSTSLINAVNVIKDMNDNNKRKIPDDAPIEFISKRWKNHVCNEDGTINKRYYEMAVL
                     TELNNAIHSGDIWISDSKQHKNISKYLISDEDWKRSCLKNEAGISVSLSIDEYLKERQE
                     TLLDKLQYVSKNVKNLEDVSIDGGKISLKRLEKNVSEESEKFNSMIYGMIPKISLPELL
                     LEV"
     gene            <40286..41464
                     /locus_tag="LL065_RS24825"
                     /old_locus_tag="LL065_24810"
                     /pseudo=""
     CDS             <40286..41464
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013676.4"
                     /locus_tag="LL065_RS24825"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24810"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="FEQHLTHASTDKPPKNEEIPILMAAIMALGTNIGVQKMADSTSDI
                     TYAQMANISEWRLHDDAFKKAQATLVNYQHHLDLSQYFGDGTTSSSDGMRVEVGVSSIY
                     ADKNPHYGIGKGLTMYRHVSDQYSAYSIDVITTNSRDSLYLLDGILGDESELQIEGHYT
                     DTAGYTDQVFGLFHLFGIRFAPRIRDLSECVLFSFNDTEEFYKTIKDIVKGRINLKSIT
                     DDYESVLKLAHSIFIGKVSASLILEKLGSYSRKNSMAKALREMGEIEKTIFILEYISDK
                     NFRRRIQRGLNKGEAMNALSRAIFFGKFGEFRRRALQEQLQSASALNITINAITIWNCV
                     YLNKAIDHLKCNGGFDESLLNNISPLGWKHINFLGEYKFNLNQNGNLKELNL"
     gene            complement(41775..42662)
                     /locus_tag="LL065_RS24830"
                     /old_locus_tag="LL065_24815"
     CDS             complement(41775..42662)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025164.4"
                     /locus_tag="LL065_RS24830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24815"
                     /product="anti sigma factor C-terminal domain-containing
                     protein"
                     /protein_id="WP_268064752.1"
                     /transl_table=11
                     /translation="MLLIIPLYIVNVMIAPKMGTRYYTQVEKVLEVTNPNAYISKENDV
                     IGFLGASGQYTVSKRIGSWKSVDIYDQNSSYGLGFINGINRTMSSSSGGQKAGEWPVNF
                     DGSGNLTMMVFHPDIKYKEYKNDLALLNKVSSDSLLEMTLSFDKKYKINEVSNILPKVQ
                     ISELLIDGYTDKEMNVYKNQASENDGKATFIQEFNFIGFKTSNGFNYDANEVSNNYGKF
                     LNNLQFNFKDITYKKKFSDIYSVLKNKDQLKANKVDLIGVVVYGSPEELQKLKINPHIR
                     ATSVGIITKDIVFK"
     gene            complement(42631..43167)
                     /locus_tag="LL065_RS24835"
                     /old_locus_tag="LL065_24820"
     CDS             complement(42631..43167)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="LL065_RS24835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24820"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_226139818.1"
                     /transl_table=11
                     /translation="MNYDVIEQLYINQLSIIYKYLINLGCSKPEAEDIVQETFTRAMLY
                     MDGVIVEKLPSWLFTVATNIFRTFKKRNNRLSFYLDEERYYNSFYSEDEVGNSILSVER
                     REYVKQTLFDLKEQYKNLLLMKYQVDLSYKQISILLGIPENTVKTYLYRAREKFKERWR
                     DNYNSCVIDNTTIYS"
     gene            complement(43515..44090)
                     /locus_tag="LL065_RS24840"
                     /old_locus_tag="LL065_24825"
     CDS             complement(43515..44090)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003408602.1"
                     /locus_tag="LL065_RS24840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_24825"
                     /product="recombinase family protein"
                     /protein_id="WP_216109182.1"
                     /transl_table=11
                     /translation="MQTYFYIRVSSKEQNTIRQEVKAKEYNIPRECVYIERVSGKNVTE
                     RPVLTNLMASLKNGDKLIVDSISRFARNTKDLLELVEQLNSKGVIFISLKESIDTTTPT
                     GVFMLTVFGAVAQLERDYIKDRQREGISIAVSEGKYKGRKSIEVPKLWDKYYKMYKENT
                     IKAVDVMKILELKKTTFYKLINQYEESN"
     misc_feature    complement(44191..44210)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 18.48"
                     /tool="antismash"
ORIGIN
        1 atattatttg attatgcgac aaagatactc aatttaatgg atgaatcaaa agaaaaaata
       61 ttaaatttga atcctttatt aaaaataggt gctacacaaa caattaccaa aaactatcta
      121 tcaaatctgt taataaataa caatcttaag ttttctatat atactcgtcc tactgaagaa
      181 ctgttgtttt tactaaaaac gtataaaatt gatgtcgtgt taataaataa agaatggcaa
      241 aacagtaaaa cagaactatt acattctttc aatgagaaaa ttggatggtt aggatcaaaa
      301 gaaataaaat taaataattt taaaaatata tccgtcttag taaatagaga taaagattgc
      361 ccttatagga aagctactct tagtttcctt gagaaagtaa aaaacaactg gaacgttatt
      421 gaaatagact ctcttgacct aattctatca atgcttgaat atggagaagg aatagctatc
      481 cttccccaaa aaatgtgtac taataaaatt gtagagcatt ctgtggaagg tctaacacta
      541 gaagatgtca agatctactt gtataaaaag aacgataata ataaagtgaa taatcaagat
      601 tacggtattt tttattagta ttagtataac tacaatttat taaaatcccc attttcttaa
      661 tttcttatat tttagctgtt tctatgcccg aaacacgcgt tccattaata aaatgtgtgt
      721 atgatttata aaatagctga ctcagtttgc caagcaggaa gtttagccat cattgatttc
      781 gcagcagaat ttgctgcttt tgcatctagt ccctgtgttt taacaataaa gttagttaaa
      841 gaattcaatt tttcatcata ggattgcatt gttccatcag ggcggcagca gtatacacaa
      901 tattcatttt ctgaatcccc catagcaaaa tcttctgggc ttttcatagg cattccacac
      961 gcaatacatt gtttcatttt attttcctcc ttgtatattt tttattttgt aattaggttg
     1021 atgtaatgtt gtagtagttc atgacggtat tgctttaaaa cggaaccatt aggcgaaaat
     1081 aaatcaccat tggttatgta ataatgaatt aatcctatcc atgtattata aattagatgt
     1141 ataggcactt tacgaattgt accttgctta atctcttttt ccgcagctat actaatatga
     1201 aacgagatag tagattgaat cataatatac gtattacgaa cactttcagg aagtagtcgt
     1261 ctttcaataa tcaatctcgt ataaaatggt tcaaattcaa ttaacccttc tatgtgggct
     1321 tctaaaactt caaataaact actgtttgta tcaaccaatt catgaagtct ctgtgtgatt
     1381 ctgtttccaa attcctcgat tacagatatt aataattctt cctgggttga aaagtgtgca
     1441 aacactgttc cgtgtgaaac ctttgcagct ttggcaatat cagcagtcgg ggtcgttatt
     1501 atcccgtttt caccaaactg tttaattgct atttctatca aatgcttttt agttagtttt
     1561 ttttgttttt gccttttagt ttctagtatt acactaacct cctcatgatt gacttaatac
     1621 tcaatgactt aatactcatt atacttgcgg atatattttt cgtcaatagt tatttttgct
     1681 taagatttgt aaagtattgt tatataatac ctatatcaaa ttttaattct ggggttttta
     1741 tattcttatc aatactgtat ttcccaaatc tattaatgtg actcgtcata tacggagcta
     1801 acgaagatac aacatcttta tttatatcat aacctttaga tgaaagacta tgtagaatct
     1861 ctgacatatg aaaaatgttg taaaatataa tagtattagt aactaaatga ttatacttta
     1921 tcctttttcg ttggtcttct ctgttatttg acgtaatgac tccatcacta ccaaaattta
     1981 tccacttcgt aaatccgtta aaggattcat tcttatttga ggtttcttga ataattcttc
     2041 ttcaatcgat atctgatata tattttaaaa ggaatccagt tcttacagct tttctaagct
     2101 tactaaatgc ttgatataac ttgttttttc tactgtaact tccaatctta tgtagtatag
     2161 tagaaggtgt tattcttccc atttttattg aaggagcaac tctaaaactg taagagatta
     2221 tgtgattatt acagaaaaga aaacaggtaa aacaaagaag ttttatattg gaattactga
     2281 agcacaaaag aaagaagttt acttacagtc taatttaggc tagtgaaatg gcttttaatg
     2341 atggatacaa agcgtgataa ataattacaa tgttatatgg agggtgttta tgtatacaat
     2401 tggacaagtt gcagaaataa caggaatatc aagagacaga ctaaggtatt atgaagaaaa
     2461 aggaatactg aaacctaagt atgatacaag taataattat agagagtacg gctggtggga
     2521 tttagatatc gttttaacca ttgagtttta tcgttctatg aatcttagta caaaaagtat
     2581 aaacaatata tgtgaaaaca gcagtgttaa aagtattaag cagttaatgg aaaaaaaata
     2641 tgaagaagtt gcatcagata taacaaaact acaaaaaata caagaaaaag taggaaatat
     2701 tattaaacaa tgtgcaaata tagggggttg tgtagtaatg gaacagaaaa ccggtataag
     2761 aacagaagac aatggtattt atcttttttt aatttaaaat ctccaatatt acacaatgta
     2821 cttatttaac ttttcttttc ctaacttctc gaattagtgt tgacttactt attctagtta
     2881 tctctgtaac ttctgtatat gaattgtttt ttagcatctc aatcgcatta tttatttgtt
     2941 ttgatgtata tagcttaggt ctaccttctt taaaaccttc tttagttttt gcaattgctt
     3001 tacctgtttg ggtacgttca ataattgtgt tacgctccat ctcggcaact gctaatagtg
     3061 tagttaaaaa aaatttaccc atacttgtat tctctagcag tccaatatta attacatgga
     3121 cagatattcc tttattaaat agatcttgaa ctatgctaat gccttctacg gtatttctag
     3181 ccaatctgtc tagtttagta actactaagg tatccccctg ttttaaatcc tctatcaatt
     3241 tattgaatat aggtctatcc attgtaattc ctgtatactg ctctactcta atttcggcat
     3301 catcatatct atctagtata ttccttgtct gaacctctat ggaatgccct tcttttaatt
     3361 gtccttttgt acttaccctt gcataaccta ttatcacaat tcataacccc tttaagcata
     3421 ttgttttgac tgtaagtttt gacaccgcca aatcccttga ttatacgtca gtgttttata
     3481 ggtgtcaata ctgttaagtt atgacattaa cattttctta tacattagag ttatagccac
     3541 tatttaatat taaaaataaa aagagcagaa atttctgctc ttgataaaaa attgaataat
     3601 acggtatttt attatgattt aggacaaaaa ttccaaaact aaatttctaa actctttttt
     3661 gttactaaac atagcaggat gatttccatt ttcaaaaata accaatttag aatttttcat
     3721 ttttaaatta atagctttta atgtactttg gacattaggt attaaatcat ctttcgagct
     3781 tcctgtaatt aaaacattat tttctatatt actaagttca taattaaaaa aattacctat
     3841 gtttcttgaa aaatctataa ttaagcttgt attttgatca ataacatttt cccaatcaaa
     3901 gccatgcatt ataaaccaaa ataatttaga acctaccttg ttttttgcta tttttctatc
     3961 atctacaatt tttttggcaa actcataaga taaattttct cccataaaac tatctacaac
     4021 tattcggtta aataaattag gttgtttcaa tacagcattt aaagcaacaa tagccccgcc
     4081 acttgtacct aacagattaa catcgctaat accaatgtgc ttacataatt caataattaa
     4141 agtagaatta aaatgccaat aatttaaggg taatttatct actctctgag atttcccttg
     4201 acctaccaaa tctaataaaa ttactttaaa gtttttagaa tagaatctta attctggtat
     4261 aaacattttt gaggaagctg tatctccatg tataataact aaaggtctcc cttcaccaga
     4321 tactttataa tatatattaa tattttcata tttaaaataa gacattttta acctcccaat
     4381 aacaaacatt gtaatatttt ttaatgaata tttgttttat ataatctaca tgggagagtt
     4441 agtaattact cttacatata gactatttta gtttattaaa aattcccatt atgatacctc
     4501 cttgtagttt agtaactcac attattttac atatgtgcct taatatcaag gactattata
     4561 ctactatcga taagatcctt atagttttag atttatttat agaacgtttt ataaccttgt
     4621 gatagtatat aaagcgttga tatagtgggt tgtgtagtaa tggaacagaa acggaaatag
     4681 aattaccgtt tcttaccaaa tagtttttta ttcattggtt gcaatggtct cagcttacca
     4741 gataatattt tttttgctaa atcaaatgaa taatgcccta caatatttat atgatcatag
     4801 ccaagaggag aaagtcgttt tacgtcatcc aaattcacga tataacctgc atttcgaata
     4861 gcatctaatg ctttttccat atagactgta ttccagagaa taatagcatt tgtaactaat
     4921 cctaatgtat ttaattgatc ttcttgatct tcacggtgag gttgatgaat ctctcctttc
     4981 ttgccatata caacgactct tttaagccca ttttccgatt ctccacgatt tagctgtgtc
     5041 aaaatacgcc tgcgataatt cttgtcatcc aaaaatgaca gttcgtaagt ggtcttaaaa
     5101 attcgtccga attcgcccat tgcacgacca agcatagttg gcttaccgcc tctttgtaac
     5161 atttttataa gatttgtagg atttatagtt ccaagtttaa gtgaaccagc gaccctaagc
     5221 atatcatccc atgacttaat tataaggtct tcacgtaatt tgtgtttaga tagactattc
     5281 aagacgccat agtctgcatt tggatcaaat cgccaaagtc ttgtacttcc tatatcggca
     5341 agacgtgggc taaagcgata acccaataat gcaaatactc cgaatataat atcactgtat
     5401 ccggcggtat ctgtcattat ttcacgaggg ttagacgttg tctgttgacc taaaaccaat
     5461 tcaagtaaat ataaggaatc acggatagtt cctgtaataa caagtttatt tagtccagca
     5521 aattgatcac tgataagatc ataacttgtt ataccacgtc caatgccgaa atatcgtggg
     5581 ttgggacctg cataaatagt ttttggtggt acaacaaatc taattccatc tgcagatgca
     5641 acctcccctc caccccatga tttagctaaa gtcatcttag agatatgatc agcaagaaca
     5701 gcatttgcct gtgtaattgt ctccgtacgg aaatagtttt gttccaccca tgttaatctg
     5761 tcatattcca gtgcaggtat gcctggctga actacgggtc caagtccgat attacatgcc
     5821 ttggctatga aaatagcaca tatgctaaca gacaaatctt tgattctaga attaccttgg
     5881 cttatatgag taaattggtc tgtaaatctg gttaatgcat ttatctccat taataatcct
     5941 ggtaaatctg tattgggcat tagagattca acttgctttt tcaacaatat taaagacttt
     6001 ggttcttcaa gtcggttaat gagagagaga acaatctttt ccttaccctt aaccatctca
     6061 actcgaacgt ctggattatc atcccaattt ttaattgtat tcttgaatgt ggtatccaag
     6121 tttttcttta atggattcaa tgattcttcc gcattcgaag accaacctaa tgtgcttaac
     6181 accttacttt taacactttt ccaagctgat ccctgtaaaa gattgcttct tggatcattg
     6241 tatctatcac tttttttcag ataaatatca taatttttaa taccttcaag cattttttct
     6301 attgcccaga aagtataggg gcaagagctt atactatccc ctttaaaaac aactcttttc
     6361 caacttgctg aaattccatc agtaggtgca tccgaaaatt tatttttccc agtctttgac
     6421 tcaacttttg aaagaaaatc ccatgcagca agagcaggtt gtcctgctgc tgatgcccta
     6481 aatttaatag tggctaaaag tgctggaaga aatctacgga tggaagtata atacctaaaa
     6541 agttctttgt actcaacagt ctgatctatt ggtcttgtaa tagtatctat cattccaata
     6601 gccaatttta accgttcttt gggtatgttt gaaaatatga tttttcgtat tgtttcatca
     6661 ggtaccgttt catccaacaa caacaaacag gctttactta attctcgtgc tgagctgtcc
     6721 agatctttca aagatcgtaa tctttctttt tctccttttc tgtttgcacc attgaataaa
     6781 gttgaaaaat atcgttccat atagtcgatg atatcatctt gggaactggt agtatatgtt
     6841 atagcgaacg caactaatgt tgctatgcga cgttcatccg gcatcctttt aatggtttgg
     6901 gatctagcaa ttgaagcata cctggataaa actgatattc ttcctatagg tattcttgat
     6961 atgttccatt gataagctcc tattgaataa atcattttaa atcgtttaat tgcttttaaa
     7021 aatccaatag gagactcatg ggttacagcc tgtctaagca tttctaaacc ggttttattt
     7081 ttagcatcta ttataagcaa attttcaagg gtttctcgtt gattaacatc cgcaagagaa
     7141 gctagtttat gccataacct tgaagttgca cgttcacgaa tttgagatat aagcctttct
     7201 aaaactgtag caccaggtaa taatattttt tgttctatta acctggccat agtaagatca
     7261 aaaacaacac ttggacgttc gggtgctagc caaaagtgat tatatagcca acggactaac
     7321 ctaaaatggt gaggctgcat cataaaatca tggtaaccat atgcttgacg tatttctcgc
     7381 gtatgatccc atctgctttc actataacta tatttctcca gattattctc acttaattct
     7441 aactgttgag agatatagtg aataatatta gaaggtattt ttagtggatt gggcaaaaaa
     7501 gtaccaagga atcttactgt cccaagctgt attgcaaaac caattctatt ataatcgccc
     7561 ctatggctat gtgcagcttt tttgtcggta tcatcaagta aaaaatacac tgctaattgc
     7621 tcatttgtag gctcatcaat aaaatttcca tatctatttc tttgttcttt tgttaaaaat
     7681 tcaacaggca ttatctactc ctaaattata ttttggaaat ctaacacaat aaaatacaag
     7741 tattatgatt atatttcaca taatataaaa ttttatcata ttttactaac aatgttaagt
     7801 ggataaaaga tgtgatgatc gaaatgattg gcaaaatttc aaattttgtt gtattagtga
     7861 tactgcaatg tatattgaaa tcacatagga agaatatata gtacttaatt tgagtttaaa
     7921 tttatgaata tcttaatttc tgtgcttata ccggttttct gttccattac tacacaaccc
     7981 ccgtttaagg gaaagaatag ggattgtatc tcagagtata tttctattta agggaactgt
     8041 tttagctaat atattgtatg gacaaacaag aaagaaactt gaagatgtgg aaaaacttat
     8101 taaaaaatta ggacttcaag aatatattaa tagattgccc aacggtttgt caactgaaat
     8161 aactcaaaac aattctggaa tatcaggggg acaagctcaa gttatagctt tcataagagt
     8221 tattctttct aataaagatg taataatttt agatgaacca atttcaaatg tagatactga
     8281 aacaagagac ttaattctag gtattttaag ggacaaggat tttgagggaa tgttaattgt
     8341 tgtttctcac gtcatagaag gtatggattt tcttaataga gttattgaaa tatgataatg
     8401 ttttgaaaat taataataaa ttaaggggac atataaatga aaatattaac ttcaaaattc
     8461 aaaaatcgta tatagatacc cacattggaa tgccgagcct atacgctagg gattataagt
     8521 aatcaaaaca attaaaatat actctaatgt atctttagca attacaacta tcttgtgtgt
     8581 cctcaattgg atttatcatt aaatcaaacg gtatatagat taaatacaat tactttgaat
     8641 tatttacctt atagggttac tcatgaaatg ggtttaaatt gtataccaag aggttaaaat
     8701 aataaagtaa atatcacccg tttattttac ctaggtttat agaaattaca gtgtctttaa
     8761 tacagaatta atggtattag ccacaatagc tataacaatt aataataaac tcttttgaaa
     8821 atattcatta ttatccttta ttggttaaat gattagcttc ccaaaataca attaataacc
     8881 tcaaatatta tcaaaataag tccactatgc ttttgttatg cattccagct atcttgattc
     8941 ttactattaa ataagataaa tataatagat aggcccttat ttaaccgttt ttattgacca
     9001 gttatatttt aattgatttt gatttaattg ctcctattgt tcctttttag ttttagtaat
     9061 tccatatcca ttgttatgct tatattctct ttgtttctta gttaatccat taacaacctc
     9121 atcatgatct tcatttaaat tctaaatgtt ttttcctaaa ttagtgacaa taaaatcttt
     9181 gtatttaata cctgttaaat aaatgctttt tacttttcat ttgcttatca acaaggtaac
     9241 caggagacaa caaactagac tataccataa acaataggat tatcaacttc ttgtcttatg
     9301 ttgcatctta acctcagaat atgctgaatt tttatatata tttacatata aaacatattt
     9361 gagcataatt gttgaaatgt gtacaataat agtgtattat atagtacaag cttgttaatt
     9421 aatgtatgga agtaaatagc cttaaatatg tatagaggaa ctttatgtat ttagccggat
     9481 gatcgggtta taaattatga aagtccaaca aatgtatttt gctgttttat tatgctggct
     9541 tacttgaaaa ttacaaagta tagagagtaa catgttaata ttcaagtata gatttaaaat
     9601 aaaatataaa aaaggtggaa gggcggtgat taaaatggct aatttcgatg attttgactt
     9661 agacattaac attaataaag caagcgcaaa ggtcagccag agttttccta cgcaaagtgg
     9721 aggatttaat acaaatacca tatctatatg ttcagttcct tgtacttttc caataacgac
     9781 gataacagta gcttgtacaa aataatgata aaggataaca atgattaatc attgttatcc
     9841 tttatcatta taaacaaata aaatttagaa ttattaaaat ttaactataa ttgatgttag
     9901 ctaccaaagg taaaagaaga tttcattggg cataaacttt ctttcgttag cttttagtat
     9961 agcaatttgt gatactttaa taattttgtg aggtgtatcc atgaaaaata atttatataa
    10021 aaatgtaaat acatttatga tcagaactcc attaaaacct atagataagt attttgaatt
    10081 ttttaataat aatgttgatg gtgaaaaaac aaaagaatat gtgaaagagc tttgtaacga
    10141 tccagttttt agagaaagta tattaatatc aagtaaaagt ttatatgaca caataattaa
    10201 ttttattaat ggaaaagata ttaaaaagca agagtacttt tttcgctcaa tatataaata
    10261 tttaattagg atgagtacac gaccaactcc gtttggatta gtttctggtg tatgttttgg
    10321 aaattattct gataaaactt ctattattta tgaagataat caatttaaaa aattcgcaag
    10381 atctgattta gaatggatta tgggcctagt aaaagtatta gaagataaat actatcaatc
    10441 gttaatgtat aaaataaatg gatatatttt aattaaaggt gatagggctg ttctgcctca
    10501 ttctacatta aaagaagata acgatagtgt aactgatatt agtattagag caacagatgc
    10561 tttcaaagtt gcgtatgaag gtgcacaaac tactatttct tatagtcaat taaaaaacaa
    10621 gttattaata aaatatcctg aggtactaga agataaaatt aattttttct taaaagaatt
    10681 aatagataaa gaatatttaa tatctaattt acgtcctcca ctaacagtaa ttgatcagtt
    10741 tgattattta attaaggaaa tacaacggtg tgatataaac aaaataatat tagatcaatt
    10801 aactaatatt caaaaaaaaa taaacattta taataaaacg tatgttggtg agggcgagag
    10861 catttatata gagttatgca aggatatgaa taatatggaa aaatgcaaaa cgccattgca
    10921 ggttgatatg aaattgaata tgaaagagaa gacaattaac tcaaaaataa tagatgattt
    10981 aaatgaattg atacatctat tgcttttagt atcaccgtct agtcataatt cacaagatta
    11041 ttttcaaata cacaaaatgg atttcatgga gaagtatggt caagaaagag aaatcctttt
    11101 actggaaatg atcgataatg atttgggtat aggagcgcca gcaacttatg ttcatcctaa
    11161 aaacaataga tcgaaaactt ttaattctag cgatttagtt aataagaagg ttaaatccta
    11221 tttgttacaa aaatatatat atgcattgga taataattac aacagcatag agataaatga
    11281 tgatgagata aaagcgttag atttaccaca gtataattat gaagaaattc ctaattcatt
    11341 agaattaaat gtgatagtaa gggcagaatc gaaagaagaa ttaaaaaaac aaaacttaaa
    11401 ctatcacatc ggtcctaatg taggttcacc acaagcaggt aaagctttcg gaagattttc
    11461 tcatttaatg aatagtccag aaaagttttt ttcagaatta aatgataata ataaaacatt
    11521 aattgatagt gatgaattta ttcactgtga gcttgtttat cttggaagta aacttagaag
    11581 tgcaaatgta actagaaata ttcattgtaa tgaatatgag attgccttgt ttacaaatac
    11641 ctctaaaagt gatgaatatt cattaacctt agatgatatt ttaataggaa tcgaagataa
    11701 tgttttttat gctaaaagta aaaagctcaa caaaaaattg tttattacgg taaacaatat
    11761 gttgaattca tctatggcac caaatgcagt tagatttttg tatgatataa gtttagatgg
    11821 agggaaaaaa tggtttgact tcccttggaa ttatgcattt tatgagtttc cttatgttcc
    11881 taatattaaa tataagaata taactatatc acaagaaaaa tggatacttg actctataaa
    11941 tgttaaggga gataaaaaat tagggtttga taaatttaaa gattctttta aattatattg
    12001 tagctcgtat aaagttcctc aatatgtgta tattacattc gctgacaata ggatattact
    12061 caacttagag gataataaat gtcttgaaat actctaccat gagtttacaa ataatttagg
    12121 tgatactatt acccttaatg cttatgaaga agagccttat aatattgtaa ctggtaatga
    12181 tggaaactat ttttgtgaat taattgtacc cttaataaaa gttaaaagtc atcatccaaa
    12241 agatatacaa atatctaata aatcaagtga cataccaagc atatcaccaa ctagattaaa
    12301 acttcctttt gatgattggt tgtactttaa attatacgga actagttcta gcgatgataa
    12361 attaattgca tttttcatat cagaatattt ccatgattta gtacatagtc agaaaataga
    12421 aaaatatttc tttatgagat atgtagatcc agagcaacac atacgtttaa ggattaatgc
    12481 aaaacaatct aatcttttag atatctatcc aaatttgcag cagtggtttc gttcattaat
    12541 tgaaaaagga ataataaccc atattgctat tgactcttac gatagagaaa tagaacgcta
    12601 tggcggaagt aatctaatag atacggccga aaatgtattt tatgcagata gtattgtaac
    12661 agaagatata ttaaaggaaa agaaatttaa taatcttact ttgagcgatg agttaatagg
    12721 tatgatttct attatacagt atatggatca atttggttta gattatgaca atcaatgtga
    12781 ttttttagaa tctttggttg aaaaaactga ttatagagaa atctttaaaa aacaacgttc
    12841 tgaatttatg aaattatgta atagtaatga taactggaac ggattaagac agcatcagga
    12901 aggcaaacta ttattaaaca tttttaataa tagaactgaa agtatacaaa tttatagtag
    12961 tgaaatacga aaaagaaata ataattcgct gatgtctgaa tggtcaattt taaatagtat
    13021 tattcatttg cattgtaata gattgtttgg gatcaataga gaatttgaaa agaaaatttt
    13081 aacattaaca cgacatactc tacatgcact acgctatttt aaaaaaggaa gcgaggttaa
    13141 aaatctcgtg aactaagctc aaacaaagtg atttgttggt tagtttaaat ataaaattca
    13201 tctaagaatg ttttaacaaa acattcttat tggaaatgag aaaccttaat aattagcaca
    13261 aaaaaatcca gaataaaaaa atttacatag ttcattctgg attttttagt aactgtgttc
    13321 taattttata ctgttcaatt taaataaatc aaaaataata taaataactt gaattttcta
    13381 agttatttgt gcaatataaa ttacaaaaaa attctgaggt gaagttgttt ttttgtaaaa
    13441 ataaatttaa aataagcaat gccttgagat ttttggaaag ttcacataaa ctatgaagag
    13501 gtgattatat tgaaaaaaag cattgataat ttggttaaag atatagcaaa aaaactgcaa
    13561 agttttgact tcttacaaaa aatgattaat gacaaaaata attatataaa tatcaatgat
    13621 ttagaaataa atccatatga tgcaatggcc ttaagcaagg gtgtaccttc tttatgtatg
    13681 ttgtatggtg aaatgaatga acaatatcct aaagaagatt gggatattgt tgatcatcag
    13741 tatattaaaa tattaggtga tatgataacg gaaaatggaa ttgaagagct gtcaatgttt
    13801 agtggtgctg caggtatagg cctttctata gtatgttcat ccaagcaaag agaaaggtat
    13861 gtttccttta tttccaatat taatgagttt ataaaaagta atataaaaga gtttatggat
    13921 aaaattaaag ctaatcccta ctgcaatata actaattatg atgtaatttc gggagtatca
    13981 ggaatagcta gttattgcat gttatttcca caagatgacg gcatgacaga catattaaaa
    14041 gaaatagtaa cctatattat tgatatttgt agggataaaa atatagaaaa tataagtgta
    14101 ccaggctggt atattccttc agaaaatttg tttacagaaa atgacaaaca acaatggcca
    14161 aaaggatgct ttaatattgg attagctcat ggtattccag gtatattaat tattctatgt
    14221 aatgcgctta agcttggtat ttgcttagat ggccaaagtg attgtattac aaaaatagga
    14281 gattttctta tacgatttcg taaacaggac aataatggct gctattgggg ttgtattgtc
    14341 tccttagatg agtatattga tgataccatg gatgatccat actttagaga tgcttggtgc
    14401 tatggcacac caggagttgc atattcttta cttttagcag gaaaagtttt aaataatgaa
    14461 tcctatataa cctctgctat tgaaggaatg caaagctcaa ttaaacgact taaagaaata
    14521 tattctccaa ccttttgtca tggattatcc ggagaaatat atatcgctta tagattttac
    14581 gaattaacaa acttagtaga atttaaagat gcatatattg agctttcaaa taaactaatt
    14641 agtttttatg atgccgaggc tccctttggc ttttatgata tagaaatagc taatggtaaa
    14701 tgcaagaatt ataattatat tggcttaatc gatggaactg ttggcatttt attaacatta
    14761 atggcaatac aaaacgggaa aaaaacacct tgggattgtg cttttctttt agcagacata
    14821 taatttatag gtttattcga ataaaagttt atcttttaag gaagtgaaaa gtagttttag
    14881 gggctagctg gacagggatt tccattaaat gtattaaaac aacgctacta tatcctttat
    14941 ggtacttata tttaaatatt atttacttaa cgtgagcaat agtcgcgttt tatatccatt
    15001 ttatgtctta gtgtgggttt tgtaggaaaa gttggttcta tccgttatta taaagattaa
    15061 atgtagcagg ttaatcagaa ttgtaaattt attggtaaaa aatatattat atggtataat
    15121 tgttattata agaatggagg tgcaattatg ttaaaaaaaa taccaatatt ttcattgtta
    15181 ttaatattga tggtagtggt taccttaact acaactagtt ccacaaaagt tagagcagct
    15241 acacttaata gtggatttgt atcatcgaaa tacatagtaa ttaatgaccg acttagtctt
    15301 ctatcgtttg gatcctcgag tggtacagta aaattagatg cttctattag tgctcttaat
    15361 gtaatggatt cttcatcatt atctggaaat ataaaagact cattggcaga tggctatacc
    15421 gttacggtcc tttcacctgt aaatagattt ttaccacctg tttttcaacc agttttacct
    15481 ttgttttatc acattgttta tttaaaatag attttagttg tgtttttgca ggtttaatgt
    15541 tagaactttt atgcaaatgg tctactcata tttagtttag atatgggtaa agaacagttt
    15601 aatggacata ttttcaaata aatattattt gggagttgaa tttacatggt gggagtaagt
    15661 attgtattat tatgcttact tatatttgat atagtagcta tattgataca ttattcattg
    15721 acttattatg gtgaacataa aaaaatagag ttaaatgttc taaggaaaaa agatatataa
    15781 aagtttaccg aataaatagt attttgttcg gtaagctttt atttttgttt tgggtataat
    15841 aattaaattt aattattatt acatatagtg ttgggtattt ttacttatag gggtatgaag
    15901 aacatagctg tcaccagaag caataggaaa gttccgaatt tcattttgga acttgaactt
    15961 aggtgtattt agagcctttt gttgagtgtt ttagattgat agggtaaact aatctcaata
    16021 aaagttccta ctcttgacat tataggaact ttcgaaaggt gatatatgga atctaataat
    16081 aaaattgatg agagttttaa atttagtgaa atagaaatag atattgtaca taataataga
    16141 aaagcagaaa caaaaatagg ttttgcagtt ctttataaat tctttcaaaa taatgggcgt
    16201 ttcccgtatg acaaatttga aatttcaaat gaagttattt gttatatttc tgaacaaatt
    16261 ggagtagata gttcttgtta taatgattat gattggaatg gaaaatcaat aattaatcac
    16321 agaaagcaaa ttagagagct cttcttattt agagagtgta ccgttcagga ctatgatacg
    16381 attaaaatat ggattttgag taacgtcctc cctaaaaatg atgattctga attagttaag
    16441 aaggaagtat ataagcaatt caaggaacta aaaatagaac caaccacacc agaaagaata
    16501 gaaagaatag tcagttcagc tataaataca tatgaaaata atatctttga aagtattttt
    16561 aataagttgc cagttgaaac tattctaaaa tttgacttat ttcttgtaac cgaatcagaa
    16621 aataataaca tggaacaaat aatatggttc aatgatttca atattgatcc tgacggtgca
    16681 aatattaaaa gtgtttttaa tgaatctaat aaattaaaaa ctattgaagg tatgatgatg
    16741 ccagaagata ttttcaaaga cataccatca aaacttttaa aaaagtatta caaacgtagt
    16801 aaagctgaaa atatcagcga atttaaaagg tatccggatg ccctgagaaa tggtctatta
    16861 gctatatttt ttcattttaa atcaatggag attaaggata atttagtgga tttacttata
    16921 aaaatactga acaatttaga cacaagtgca aatagaaaaa taaagaagga acttgcagag
    16981 agcacaaatt atactagaaa taaaaataaa ttacttttaa aaattgctaa agctgttgta
    17041 gagagcccag aggctaagac atgcgatctt catatcaaag gcattatagg cgtattttgc
    17101 cggatataat aaatgcgtta aattttaatt caaataatga taaatataag cctataataa
    17161 aggcaataga acttataaag aagtatttag cttcaaaatc acgttgttat ttaagggatg
    17221 aaatagttcc actggagggt gttgttagac ctatgtggaa agagatgata gaagataaat
    17281 cagggaaaaa taacgaactt agaattaaga gagctaacta tgaactatgt gccttgcagg
    17341 ctttaaagga taagattcgc tgcagagagg tttggataag tggcgctgat aaatatagga
    17401 atcctgatga ggatactact tagcaataaa tcagccttta gatgtaaatg actttattga
    17461 aaagataaaa tcatctatga aagattcctt atctaagcta aataagacta ttcctaaaaa
    17521 tgaaaaggtt aaaatcctag atataggaaa tggaagaata aaaatttcgc catctccaaa
    17581 acaaccagag gcaaaaaatc ttttgaaatt gaaacgtgaa atatcaaatc gttggcctga
    17641 tttgaattta ttagatgttt ttaaagaagc tgacttaagg attgacttca caaaacattt
    17701 aaaaactagc gcaactcaag aaaggttaac tcgagatatt ataagaaaac gtttgttagt
    17761 ctctctttat ggaatgggaa caaatatggg actaaaagct gtttcttcaa agggtttgga
    17821 tgaaaattat atggatttgg agtatataaa aagaaagttc ataaacaagg ataatttaag
    17881 agcggcaatt gccgaagtgg taaatgctac tttgaaaatt cgtagtcaaa atatttgggg
    17941 tagtgcgaca acaacttgtg catcagattc taaaaaattt ggagcatggg accaaaattt
    18001 aagggcagag tggcataaca gatatcatgg tcgaggaatt atgatttatt ggcatgttga
    18061 gaaaaagtct ttatgtgtat attctcaagt gaaatcctgt tcatcgtcag aagttgcttc
    18121 tgctattgaa ggtgttctta gacattgtac tgacatgagt atagaaaaaa actatgtaga
    18181 cacacatgga caaagtgaag tagcttttgc attcagttgt ttgcttggat tcaaactaat
    18241 gcctcgtatc aaaaatatca acaaacaaaa actatataaa cctgaaataa gtgatgcaga
    18301 ttattcgaac attgaacttg ttatgaaaaa gaaaccaatt aattgggaat taattagaca
    18361 gcaatatgat caaatggtaa aatacgcaac agcattgaga cttggcactg ctgatgcaga
    18421 atctatttta aaaaaattca ctaaaaataa tcttcagcat cccacatacc aggcattaag
    18481 tgagcttgaa agagcaataa aaactatatt tatttgcaga tatgttatgt ccgaagaaat
    18541 gcgaatagaa attaatttat agccatgtta atccatatgg taattttaat ttagatatgg
    18601 ataaacgaat acatttgggg gtacaaaaaa atgcctgctg aattacaaag aacatctccc
    18661 aagaaaaaag caaaggaaat tacaaaatat cttcgtaaag aaagacctga ctataattat
    18721 ttgaaaagtt tattcaagta tcttagagaa gaattagaaa ttgagattcc acgaaacgca
    18781 agaaaattac catatgtgcc aacagaggac gaaataaaaa attattataa agtagtttgg
    18841 aactctaaaa actttcagga catgttaatt atcaaggttt tgatttatac gggtgttaga
    18901 gtcagtgagt tagttagcat aaaaattagt gatatagatt tatttaattg tcagataaga
    18961 attaatcaag gcaagggtaa taaggatcgt gtggttcctt tcccagaggg atttaaagag
    19021 gttcttggta tacattgtaa caataatctg aaaaatactg ccacttattt atttgaatca
    19081 tcatggaaaa agaaatatac cgataggggc ataagaaaaa tcttagaaaa atattctgtg
    19141 caagctggtt taaaaacaat gatatctccc cataaattaa ggcatttctt gtttacatgg
    19201 ctaaaaaaac aaggcataga cgatgctttg atacaaccat attcaggtca cgaaagcaga
    19261 aaaacccttg aaatatattc gaaattatca attgctgaag ctcaagaggc ttatgatgaa
    19321 gtgatcaata attttccaat ataaggtatt gcttctggtg acagctatgt tcttcctacc
    19381 ccgtatatgg aaacaatgga aaagggttag aactagattc aagtaactta aaaagagagt
    19441 actatcaaaa caaaaggctt gggaatatgc aaatacacga agaagttatt ggcgaatatc
    19501 caagagccca attatgaata ttgcatataa agataaagac ctagaaagtc taggtctaat
    19561 cagtataacg aaatattatc ttagaacttg ttagttctta tagaactgcc ttgtaccgaa
    19621 cggtatgcag ggtggtgtga gaggtcggta gataaattaa ttatctacct cctactcgat
    19681 tttaaaaaaa aaaggttaaa ataaatacct gttgaaggta tttgtgtgat ttacgtaagc
    19741 gtcaaatatt acccacattt ctattctttt aaattcatga gataatagcc tcaatgcaaa
    19801 gaagctatta tctcagttac acatttttta tttattgctt ctggtttcag ctatgttctt
    19861 catttgaaaa ttgtaattat ttttataacc tattcactca attaaatatt tcaatttata
    19921 ctaaacccat tctcttttcc taaatcgtat aaagcctatc aagtgaaata ctatagtaag
    19981 tgcaacatta ataaaaatga atttaggtac tcccgttgat agtgacggga ctacaaaagg
    20041 ataactcaat gggcaatata cccattgatg ttctgattgc gatgccaaaa atccagatag
    20101 taccattaca attcctatac ccaaataaac tattaataat attttttcta atgaaaaaat
    20161 ataaaagaaa gatattattg aaaaggtgca taaaaatgat aacaataaat ctagtaaaat
    20221 actctgaaaa gctatttgga aattgcttga aataacctta actaacaata tccctattaa
    20281 gtatcctaaa taatgtaccg ataccattcc tgtcaaagta aacatcttaa taaaatatat
    20341 cttgtttttt ttcaatggca tactcattaa aagtatccag ttgttatttt tttgctccat
    20401 ttccccaaca atcctacaaa ttatcataat atataaggga accataatga tataaaaaaa
    20461 attacggaaa acaatatatt ttaataggcc attatcgaaa gtatttgaat tatttaatgt
    20521 aggggctaaa tatattatgc ctactaccaa aataattggc aaaattaaag ttatactaaa
    20581 taaatgattt ttaaaatatt tatataattc agctcttagc atattttccc ctttcactat
    20641 ctatagatat ttttcctatt aaatattaaa gtagagacta atagtccaaa aataataaat
    20701 acacatgaaa taatcagtat aaatacagtt tgattccaat ttgctctaaa actataatca
    20761 gcaaatgaat aaggattgaa tttccctatt atacctttta aatatgtatc ttgtgatatt
    20821 gatccaagca aaaaagctaa aaacaagctt atccatttca atgaaaatat atttaacaca
    20881 atcatttgaa ttgctgacgt tgccaatgct gaactccata atattaaaaa gcaccttata
    20941 aataaatcta tatccagtgg atcttttaca cctgttataa ctcctgatat ggttattgat
    21001 ataatattaa aaaaaattag tatagtaatg tatttgcaac taacaatata ttttgctata
    21061 ataaactttg attttttaat aggctgtgtt aaaagcatag accacccatt attttttgtt
    21121 tctgtagaaa acacatgaat taaaattaaa gttgcaaaaa atgggataag tgcaggaaaa
    21181 tataaaacac gttgttcttt aaatatcaat tgccaacaag ataaattcat tctttcctga
    21241 tgtacaagaa gatatcctgt ataccgatag tgtaaatcta ttgtaagtaa aaaatttata
    21301 gcaaacggaa ttaaaataga cataacaaaa atccatgtcc tttttagctt gatttcttca
    21361 cagtgtaaaa gtttaattaa cataatctaa ttcctccatg taaaatatag ttttcaagtt
    21421 ctacaatttc cacaaatctt atcttaaggc agaataaaca attattatta ctacttttag
    21481 atataatttt cacaaatcat atctaaaagt agtaataata attgtttatt aattcatcat
    21541 ttttaaataa atatcttcta atgaattagt tttatcatcg atactagtaa ttccaattcc
    21601 ttgttccatg agttttttag aaatatattc cacagtatag tttccttcaa ttactaaatt
    21661 attgtcttga tttataacag gtatattaat actactgaaa tattcaatag ctttttttag
    21721 ctcagttacc cctaatgtaa ttctcctatc atgagtgtcc attagttgct gtaagtcgcc
    21781 ttgataaata agatgtccat tttttataat tccaacttta tctgccataa gttccatttc
    21841 atttaacaga tggctggaaa ttaaaaaggt aatctgtgaa ttttttgcta acgatttaat
    21901 taatgtccta atttcatgta taccagaagg gtccaatcca ttaactggct cgtctagtat
    21961 aataagttta ggatttccaa taatggctgt agcaattcct aacctttgtt tcattccaag
    22021 agaaaaatta ctaactttct tttttgcaca atctttcaaa ccaactaact caagggtagc
    22081 atttatatgc tctgtattaa tctgtttcat taaacaaact atttttagat tttcccatgc
    22141 atttagatta ccataaaagg aaggtgattc aaccatagcc cctatatctt ttaaaatgga
    22201 ttcacggttt gaagaaatat ctttcccaaa tatttctatt gtaccattat ctgggtaaat
    22261 tagaccaagt agcatgcgaa tagttgtcgt tttaccaact ccgtttgggc ctaaaagacc
    22321 aaatatgcat cctttaggta tccttaaaca taaattctca accactatct ttttattaaa
    22381 actcttttgt aagttattcg tattcacaac tatatcactc attagttatc tcctttttta
    22441 cattacatct aacgataaaa tagatgggta attattattc gctagtctta ctaaagagta
    22501 tccaatgcca gaaatgccct gcataaatga atagtctatg aggtaagaat catctcctaa
    22561 agttattcca ttattttgta tatatgataa ttcagtattt gcaaaatctt tagctaaact
    22621 tatcaagcta tccatttttt ttattttacc aatttctaaa agaatatcaa tattgccaaa
    22681 agtaccatga caaatgctac tagatttaca tttatgtttt tttgtgtttt caattccatt
    22741 caataaatta ttagttacaa tattgttgtc atcatttaat aaattttgaa ttttaaccct
    22801 acttagagaa ataccagctg ctccatagca ccaataagat aagtactgat tttcttcacg
    22861 caaatcagcc caattatact cagaaggtac ataatacatg ttttctttct gaattaattt
    22921 cataccaaaa ccaatatatt cttgtttgtt tgtcgctata cctaatttta taagtgccca
    22981 tgcataacct gaaagcccat gtgccaatcc tgttaataaa ttgtcatgtt cttcaatcag
    23041 agacttgtat aaatctcttc ctagcaattc agctttttca agccaaattt tatcttgttc
    23101 tttttcaaag atatttaata atactacaat caaaccagca gtacctgttg caaaatcttt
    23161 agaacaattt tcagctacat taatttctaa tagcagttca tgtatttttt tgtaatataa
    23221 tttattattc gtaatcttat acatattgta gcatatatat atttttgaac caatccctga
    23281 aaatgcggat aatgaaataa gtgaatctgt cttggataac tggaatttta aaaattgttc
    23341 tgccagtcga acatattttt gttccttaag ttccgttcct aataaggcta aaaatagaat
    23401 aattccacca ccggtatata agttaaaatc catagtatca atattttttt tcgtatctga
    23461 tggcccaaat gtcattataa aacttgcttc actttgatca gaattaaaca ccgataaatt
    23521 atatatctgg tcagcaatta attttgcatt tgaaagataa ctatctttct ctttaagttc
    23581 atagttatac atgtaattgg ttacagaacc ttttattgag cttaaagatt gacttatgta
    23641 atatagctgt ttattaaggt cgtttttatt gaatgcttta agcttatcct caataacatt
    23701 ataggctgat ttagggaaat agttaaggat atttttatgt tcatttccaa taattgtttc
    23761 actatttatg taagacgaaa aatatgggac atcatgtttc atcaaagcat ttatttcgca
    23821 ctcaacaata tcgttattaa atgaactatt atgtatcttt gaaaataaat tttgcattgc
    23881 ttccatagac tccagatatt taggatatgt gcttgattct agaaacctag cataaacagc
    23941 agtcggtcta agaacatgtc tgataatgag catactttta ttaacaatat ttaatatttc
    24001 atcactaatc tcttctaaag cactatagca ggttgaaaaa ccatttttca tacttgaaaa
    24061 attcaattta ggcgatacaa tttcattatt aaaaatcaaa gaattttttg tttttggtga
    24121 ggtacaagcc tctttacaaa gaaggatgtt atcagttccc aaattttcaa tatgataata
    24181 aaaccattta tttgacaccg tgtcatcatt tccggccatt ccactcaaat caaaatcgaa
    24241 acatccagtt gaaaaattta caggtaataa cattgttccg aaaactgaaa cagaaatctc
    24301 tctattaatt tctgaagtaa ctgtatttgt ttgtaatgtt tggctaaaaa tattaattaa
    24361 tgtttctaaa tcaaatattg caggagtatc cttacatgct aaaacatttt cataatgcaa
    24421 atcgctacat gaaaacatat aaaaaataga aagaaaaact cctgtacgat aataaaattt
    24481 atatgtatca gaagaatttt ttgcttcgct ataaacagca tattcttgcc atccataatt
    24541 agtacggtct atacattcta acttttttaa atcatattca aaagtaactt ttttattaag
    24601 gtaatcaatt atttcgttaa ataaactttc tggtgaaagt ccgtgaggtt tatacacaat
    24661 atatttttcg ccgaattgta aaatcgtaac tttttttccg ttattgtgag agtcacctga
    24721 agaaatattt atatttataa gattatgtac attcatatta aatttgctct caatatcttg
    24781 tttatcttgt cctaatcgtt ctaatatttc atctataaga attaaacgat cagttatttt
    24841 tgtatctatt aaatatagca atacaggata tttagaaaaa atttcttcca aatataattc
    24901 atcaattaat ttttgattaa aataattata tctgtcaatt gaattttcac cttccaattg
    24961 attatttgac tttaaagtat ttaattctac aatcaaagta cgtattgata aaccagtaat
    25021 ttcttcagca atattaatta atagcgaaca cattattgtg tgtttatcaa tttcaaacga
    25081 atatttaaat aaaaactttt caagagcaat ctctatatgt aattcacaat aactcaaaaa
    25141 tgtcttgtga aagtttccaa aagcagttga caagtcattg caaattgaat taacagtatc
    25201 tgacgattcc caattactta gatatttatt ttgaataatg ttttctctta ccataatttc
    25261 acctgttcct tacttataat aatatttaaa ttaacaaaaa acatttcttt cgtattccca
    25321 aacagcctgt actaatttat agtaaaagtt taattaaccc ataaataaat cgccctaaaa
    25381 ttatcaatca taaaaatttc ttgacaaagt ggtcgaccta aggaaatatt atatcatttt
    25441 cattttatat ggaaatgata taatataata ttacagtttg acttctagac taaatggacc
    25501 attatttgtt acagcttttt gtacaagcac ttgttactgt aaacaatgca gaaacagcag
    25561 ttgctgaagc tacagttgcc gaaatagcgc ttacaacagg tgtagtaccc ccattaatat
    25621 cactagaatc aactaattca accaattcat cttcactaat aaaaccagca tttttgcaaa
    25681 tttcgttatt ttttatcatt gcatcttccc cctctttttt tactttatag taagttttat
    25741 acaactacat tgtatcatga ttatacttat tttgcaaata tatataaatt tagtaaatat
    25801 ttatttggtt taataagatt atctaatatg taacaatata acttcatttt attatgatta
    25861 tcccacaaaa atctttgtaa ttacttccaa acgtagaatt tatgatataa taataccaaa
    25921 agaaccattt taaggatgat gactatattt tgtaaaaaac gtttttctca aataaattag
    25981 gtgtggaatg cgtattatga ataagcggag aggtgttttg tatgggttcc aatttatttc
    26041 gtgaagctag ttttaaaaaa atgttgaaac ctgaggagga taatatcact gattatgtaa
    26101 aaaatataca tgcaaaaact tgggttattc ttttagcaat ttttatttta ttggttagca
    26161 ttcccttttg ggtatttact gtaacattac caaacaaaat agaactcatt ggtgtatcta
    26221 aaaaaaatca attagtaatt tatctttctc cagaatcgtg taaatcacta acaatggatt
    26281 caactgtaaa aatagacaat acatatgatg caaaaatttc aactatatca tctataccac
    26341 tttcaaagag cgaagtaaaa agtacactta agttagatta ttataaatca aatataacct
    26401 tatctgattg gaatatggtt gtcaccatta catgcaacac taattcaatt aaagatgata
    26461 aattatacaa tgtaactatt actaacggtt atattgattt gataaattat taaaaaaatt
    26521 gataaaggag atttgcaatg ttttataagt cttatgtaaa agtacctgtg gttatgcagt
    26581 tagaaaatgt tgaatgtggt gctgtatgtt taacaatgat tcttgcacat tacgggaaat
    26641 gggtaccatt ggatcaagta agagaagagt gtggagtatc tagggatggt tgcaatctta
    26701 ataatatgac acttgctgca aggaaatatg gattggaagt acataattat agttgtggat
    26761 taaatcatat tatgacaaaa gcaaaatcac cttgtatcat tcattggcac tttaatcact
    26821 ttgtcgtttt aaatggattt actaaaaagg gggctatggt aactgatcct gctcaaggga
    26881 gggtaacaat acctatagaa gaattttctg aaggctttac tggtgtttat atggaattta
    26941 acaaaacatc acagtttgtg gcagatggaa aacgtcaaag tatttggatg tttattagaa
    27001 atagacttgg taattcaatt tttactttaa gttttatttt acttacaagt gttattactt
    27061 gtattattgc attaatttat ccagtactgg gccgactgtt catcgactat atactaagta
    27121 aaagcaatcc ttattggcta tataagctca ttagtgtaat gctattattg ttattatctc
    27181 aaattatagt tgctgttatt actggaatta cttcgctaaa aatacaaggt aaatatgcta
    27241 tacacgctga ttactccttt attaagcatg tatttcgatt accacttagc tttttttcta
    27301 atcatatggc aggcgatatt tctgttagac aagattcaaa tcgaactatt gcatatacat
    27361 taattcagat gttaactccc acgtttttaa acttagtgct gctgataact tattttttta
    27421 ttatgattca atacagcgtc ccattaacag ttatagttgt ttccattact tgtataaatt
    27481 ctgttctggc tattataatt tccactaaaa gacttgaaat atcacgagtt caagctagaa
    27541 acataggtaa tttaacgtca acaactttaa ctggattaca aatgattgaa tcgataaaag
    27601 caaacggttc tgaatctggt ttttacaaaa tatggtccgg aaatcaggca gctgtcaata
    27661 acactaatgt caaactagat gaaatctcta tttcatgggg tatgattcct cagtttattg
    27721 ataaattagg aaatagtata atacttacgc taggtgcatt ttatattatg aaaaatcatt
    27781 tcacggttgg tatgctactt gcgtttcaag ggtttatggc agcttttatt aaacccgtaa
    27841 attcttttat ttctactggg caaaatattc aggaaatgcg ttcatctatg gaacgtattg
    27901 aagatataat gcaggcaaaa accgattcat tttatactat agattcgtcc tgcaaaacag
    27961 aatcatttga atatttagaa cttagcaatg ttagttttgg gtattcaaag tattctaatc
    28021 ctgttatagc cggctttagc cttaaaatac aatcaggaac aagtattgca atagttggaa
    28081 cttctggatg tggtaaatct acactatcca aacttgtttc tggattattt gaaccatggt
    28141 ctggagaaat ctcatatttt gataattcat taaacaaaat accctcaaat gaatttagaa
    28201 aattattagc agttgttgac caaaatatag ttctatttga agatactatt gaaaataata
    28261 ttaaattatg ggactcttct attactgatg aacagatgta tgcggccact aaagatgcac
    28321 aaattcattc tactattatg gagcgtggaa atggttatca gggagttctt cttgaaaatg
    28381 gtaataactt atcaggaggg caaaggcaat gtattgaaat tgccagagtt ttagcacaaa
    28441 accctaaagt gataatattc gacgaggcaa cttctgcatt ggatgcagcc actgaatata
    28501 aagtaatgca atccatccga tcccgtaata ttaccctaat tattatctca catagattat
    28561 ctattgtgcg tgattgcgat gaaataatcg taatggataa tggtaaaatt tccgaacgtg
    28621 gaacccacaa cgaattattt aaacaaaata aaatgtataa gaaatttgtt actacagaat
    28681 aggtggaaaa aatgaataaa tatataaata atgaaaagcc attaaatgat tttgatagtg
    28741 gaatacccat caaagaaact aatctaaaga aacaaaataa aatagcatta actttgatat
    28801 taaaatatta caaagtaagt tcattaactg acacttgcat gcaatcggat aatattgaac
    28861 atatgatgat taacttaatt ccggaaaaag gactaatata tcgttctatt attttgaaaa
    28921 gtgattggta taaaaatagc atgggggtta tgattgggaa aatgcgaact ggagaaactg
    28981 ttgtatttat acctaaaaca gtttcaggtt atgcatatat aaattgtaaa acaaaaaaaa
    29041 tttgcaaagt cacgaaaaaa tcttcagaac tatttgaatt taaagcattt tcttttaata
    29101 aaatccttcc taaagtatct ctaagtattt cagacttttt taagtatact ttgaaggcag
    29161 tgccctcaca aaaatatata atgttatttc tatcatattt agttgttact ttgcttggtc
    29221 ttatgctacc ttatattaat caatatattt ttagtgatat tatttctaat agttcatata
    29281 aagcattatt atcattgact tatgtattag ttggtattgt aatagtaaca actttgttta
    29341 caattataag tcgctctgta gtatataata tacgaactac aatttcagta accacacaaa
    29401 atgcgctaat agatagaata ttgtcattgc ctgtttcatt ttttaaagaa tattcatctg
    29461 gagatataac caaacggttg caaggtttta tttcagtcat ctcccaaatg attgatacta
    29521 tactaataac tgttctaacc gttttatttt cattaatata tataattcaa ataataaaaa
    29581 tgacgcctac attagcaatt ccaacatcta taattacatt attgatgctt gcctttattg
    29641 tagtgtttat tattatgcaa atacatgttt acattaaatt aaatgaaaat gatgttaagg
    29701 tatcaagcac ctttttctct ttattatttg gaatacaaaa gatcaaactt gcccgagctg
    29761 aggaacgagc atttaattat tgggataaga agtataaaaa gtcggctgag ttactatata
    29821 atccaccttt cattttaaaa atacagccac attttagttt aatggcatct tatgtaacaa
    29881 cgataatact atattacata gctgctactg ctaatatatc cgttgcttct tttatgtcgt
    29941 ttactgttgc gttcggtatg gttatcgctg cacttacatc tctttctgat atatcaattg
    30001 tatttgcaca gttttattca acagttaaac tattaagtcc tatattacgt tcaatcccag
    30061 attcagatga taataagcaa atcacaaaaa aaatattagg gactgtagaa cttaaaaatg
    30121 tatgctttaa atatagtctt caaaataaaa atgtttttga agacttttca cttaaaatcc
    30181 caagtggaca gtatatagca attactggac ctacaggttg cggtaaaagc actttgctac
    30241 gtttattgct tggatttgaa atttcgcaat ctggttctgt tacatatgat aacgtaaata
    30301 taaaagatat gaatattaga aattttagaa aacaagtagg tacagtatta caagatggta
    30361 aattattttt aggatcaatt tctgaaaata ttacattctt tgaacctcat cttactattg
    30421 aagatgcatg gaaagcagct gagatcgctg gaattgcaga cgatattcgt aatatgccta
    30481 tggcaatgtt tacagtaata agtgaaggtg atggttcaat atctggtgga cagaaacagc
    30541 gaattttaat tgcaagagca attgcatcgc agccaaagat ccttattttg gatgaagcaa
    30601 cttcgtcact tgacaatata acacaggaga atttaattca ttctcttgaa aaattgaatt
    30661 gtactaaaat tattgttgcg cacagattat caaccattca gctttgtgac aaaataatta
    30721 tggtgaataa cggacaaata atagaagaag gaacatatga atcattaata gacaaaaatg
    30781 gaatgtttta tgactttgta ttaaggcagc aagcatcagt tttagtacct gattgattag
    30841 tttaatgtta atgttacaat ataatcaagc taagtaataa actgaaacta atcaatatat
    30901 tcgaattaaa ggtggtggtg aataagtatg gcactatata tttcaatatt tgcagctttt
    30961 ataggcgctt tcgttacttt tagtattatt aaaaatgata aaaaaaagaa ataaacccaa
    31021 ataaaaggtc gctaaataaa ttaattattt agcgaccttt tgattttcta tattaagagt
    31081 agaatcctat tctagggcat tagagcctat aaaaaaattt tctaactggg aaattaactg
    31141 tattaatata ttgtattata aagttatcct tgttttatgt tgcattatat gtgataatat
    31201 ggatgatagg aatgtgttac ataaagtgta aaaattatac ctgcggtgtt tatgatcatc
    31261 taatttagat atgagtgttt atatttatat atgatggatt taaatataaa ttattaacga
    31321 gggggagtaa aaatgattaa aaatcctatt atgagaacaa aattacatca aattgaagaa
    31381 tttccatgtg gagacttatt tgaagaaatc aatgagaatt caatgacgat ggatgctgta
    31441 aatggtggag gatgggtatc tactatatta caaggtactg taggatgctt ggcaagttat
    31501 gcattaggga atcagggtaa aatatgtact tggtcagttg aatgtcaaaa taattgttag
    31561 taataaataa taaataatag atgtaatagt gaagtgagat actttgctat tacatctatt
    31621 tgttaagttt taaagaaagt tatagtgtta ggggggggtt gtgttgaata atattaatgt
    31681 ggattattgt gatactgata taattaatta ttggttaatg ttgtttccgg agcttaaaaa
    31741 tgcagaaaag ttagatagtt atctaaaaga aaatttagga tctgatttaa agcaaaatat
    31801 taataaactt aaagagtata gcaacactga taaaaaggct tttgattaca taaatttaga
    31861 ttgtacaaat ttaaaaaaaa taatgaatga tagttctatt aatataagat tttttaattt
    31921 ctatggtgta tttattgcaa aacatattaa aaagataact gatgtaatct atgaagctga
    31981 tatgatgata tacagtacag ataagttttt aaaaagcatt gtttctcaag cttcagctag
    32041 gttatatgag ttatctttaa gaacgttgat attagagatt aatgtagcaa gggaaaatgg
    32101 aattttaaag ggtgactcat cagaggaaaa attttattac tttgaaaatg tattattaaa
    32161 agacgaaact tataggaaaa acttatatca agaatatagc acgttagttg agttactaga
    32221 tgagacaatg aatgatttta taagctatat ttgtgagatt cttattagaa caaaagataa
    32281 aataggtatg attgaagaaa aagtaaataa taaccaaaaa ctaggtaaaa tcgtcgatat
    32341 acaattatca ttaggggata gtcattgtaa tggtaaatca gttgcaaaaa ttattcttga
    32401 aaataataag attatatata aaccaagatc cttaaattct gatataaatt ttcaaaaaat
    32461 attgaattta atgaattcaa aaaaattttt agttgattgt acctttaaat taataaatat
    32521 gtattcaaca gataactgtg gttggatgga gtttgttgaa tatactaaat gtaatacttt
    32581 agatgaaagt aaaagatatt ataaaagagc aggcagttta ttagttatat tatatgcact
    32641 aaatgctgtt gatttccatt ttgagaatat gattgcttgt ggagagtatc caatgcttat
    32701 agatttagag tctttatttc atactggatt aagaaatcta gaaactgaaa aggaaagcgg
    32761 gtatactaaa gcgattgaac atatccagag ttctgtttta tcggtaggac tattgccatc
    32821 gatccttgca ataggaaaag ctggtgaaaa acatagtata aatgttggtg gcttaagtga
    32881 aggagtagaa caattatcgc ctttaaaatc aattgtagta ggtaatgatt attctgataa
    32941 aatcaaggtg caatttaaaa atcgtattat ggatccaaaa gaaaataatc ctacatataa
    33001 tggaaaacaa attgatcctg caaaatattt agatgatatt ttaagtggtt ttgaaactac
    33061 atataaatgg attttagaaa atgttgaaga atttaagcag tttactataa aattatttgt
    33121 gcaaacaaga aatagagtta taattaggcc tacttttata tattctcaat tactaaatat
    33181 agccacccat ccggatttta tgagagaaaa agttcatagg gatctacttt tatctcgtgt
    33241 tgcaattgaa tctaaaaata atgacttgat agagtttgag ttagaaataa tgaaaaaaca
    33301 tgatattcct ttttttgttg cagattttat gagtaataca atatttgatt ttaatgggaa
    33361 ttgcattaaa aataaattgg aaattgttcc tttaaatgga ttttataata aattagataa
    33421 tttatcttta gaagatttaa aaaatcaaaa agaaatgatt tttaatagtt atttcgataa
    33481 agacgttgaa tatgagagaa ctaatgtaga attagattat tatccagaaa taataaatat
    33541 aaataaatgg gttgatactg caaaaaaaat aggagattat ttgatagatt ctagtattgt
    33601 aggatccaat ttaagaggta atcttgatag attttggatt ggtagttgtg ttgagaggat
    33661 ggattcaggt gattggactc atggagtgct tgatttagat ttatatgatg gaaatagtgg
    33721 tatagcttta tttttattat atctaggtat aaatactaat aatgataagt atgttaatgc
    33781 agcgtttgag gcaattgagc caataattac aattattgaa aataaaagtt ttaattacaa
    33841 taagtttaca ggcgtttata aaggagtttc aggatattat tatgtattaa ataaatttgc
    33901 atgtttatgt aaaagaagtg atttgagtga tttattaaat aatagtatca atacatttga
    33961 agagttaatt gatgaggata tagttctaga tttaataggt ggttctgttg gagtaattgc
    34021 aaccatggta tcaatttata attctacgac taacgagaag ttaaagcaaa attcattaaa
    34081 agttgcttat agagcctttg aacatataga gaaaaatatt ttaaataatg aaaatgtaag
    34141 tacaatgctg tatgaagata aagtaaaata ttcaggatat gctcacggta tagctggaat
    34201 tttagtgaat ttgtacaagc tgtatttaat agtaaaggat gaacgaatta taaaattatt
    34261 taaattatta ttggagtatg aaagagaaga ttttaaaata gaaaaagaaa atgaatggcg
    34321 tatatcaaca gataataatg atacagctaa agggtggtgt catggttctc caggtatact
    34381 tctagagaaa gttatactaa aaaaacttgg gtattatgat agtaagattg atgctgaatt
    34441 agagggtgca ctttatagta ctattaattt aggaatagga aataatgttt cttattgtca
    34501 tggggatctt gggaatattt ctattttact ttattattct aaaatttata atgataagaa
    34561 tttagaacaa aaatgtttat ctacatttca aaacatatac agtaatcatt tagaaaatgg
    34621 gtggcatgat gaaaaaaaat cattttcaaa attcaaagga ttaatgctag gtatttcagg
    34681 agtggggttt tctttgctaa agaatagtta tagttctact attgatgatt ttttatggat
    34741 agattagaaa gtttgtatat taaaatcaca aaagaatctg agaaatataa atatattttt
    34801 tcatatgaat aaatatgtga ataaagaaaa acaagttttc agtggaggaa atatgaaaaa
    34861 taaaagacat gtacctatta taaaacaatt aacacagact gaatgtgggt tatgttgttg
    34921 cgttatgatt ttgcgttatt ataaaagtaa tgaatcttta aaagaattac aagattatat
    34981 ggatgtagga cgtgatggat tatcaatttc acaaataaag aatctatttg aacttaaggg
    35041 atttaaaggt agaatattta aggttgagaa agctgaagca ttatgtagca taacaaaacc
    35101 atttattgca tattggaaaa aaagtcatta tgttgtagtt gaaaaattca agaaaaacaa
    35161 attctatata aaggatccag ctgagggtac taaagtaatt agtttagaag aatttgagaa
    35221 agatttttca aatattataa tagttgctga agttacagaa aactataagc cacagaagaa
    35281 aaagaaatat aagccatgga aagatgcatt tgctagttta ttagaacaca aactattaat
    35341 atttcaatta ttacctttat tgattgtaac ttatatatta acattacaaa ttccaatttt
    35401 aattcaaaag atagtggata aaacaatggt cagtacgaat atgtcatatt tgaatatatt
    35461 tttgttagtt atttttattg caataggttt atttttagtt agtacattgg taaaaggagt
    35521 aaagttaata tctttaaata taatattggg acgaagcctt gaggcagata cttataaaca
    35581 tttattaaag ttaaattaca agttttttga aatgagatca accggtgatt tattatttag
    35641 attaagtagt acaagcgcag ttaaggaatt attatctagt caaattatta gtggcatact
    35701 tgatataggt acgataatag ttatttttgt atatatgcta aaacaatctg tactgcttac
    35761 atttgcagca ttagtagttt ttatattgaa cctaatattt atgttgatag ttcaaccgat
    35821 atttactcaa gcaatgaatg atgaattaac agagaaatcg aaatcgcaag cgttgcaagt
    35881 agaagcatta tattctatat cttcaataaa gatagcgtgt atagaagatg atgtatatgc
    35941 aatttggaaa gactgctatg agagagttat taaaatggtt aaaaaaagaa tgaatattaa
    36001 caattatagt ggtagtatta caagtactat tcaacaattt gttccaataa taattctgat
    36061 cattggaatt tctgaatatt ttaaaggtat tatgtctata ggtgaagtta ttgcttttga
    36121 gactattgtg tctactttct ttgctttaag tacaagcata tttaataact atactcaata
    36181 tttactagct tccgaatatt tagaaagagt gacagatata tggtatagta aggaagatga
    36241 agaaggagag aatatagtag aaaagaaaat tagtggatgc attaagctag ataatatttc
    36301 tttttcttat tcaaagaatt caccaaaagt tctaaaaaac atttctcttg atattgaagc
    36361 aggcaaaaaa atcgcctttg ttggagcatc cggctcaggc aaaagtacat taagtaaaat
    36421 aataatagga ctatatgaat ctactgaagg ggaactatta tacgataata ttcctttcaa
    36481 aatgtataat aagaaaaaat tatgtagtca gatgggaatt gtaccgcaag atgcaatgtt
    36541 atttaataaa agcatatatg acaatattgt aatgaataaa aaaaatctga gtttagaaga
    36601 agtgaaaaag gttgcaaaaa tcgctcgtat agatgaagaa attgaattaa tgcctatggc
    36661 atataataca atcgtttctg aaatgggaat gaatctttct ggtggtcaaa gacaaagaat
    36721 tttacttgcc agagctttaa taaataaacc taagatatta gttttagatg aagctaccag
    36781 tagtcttgat aacataaatg aagaagccat ttctgagtat ttatccaaac aaggatgcac
    36841 tagaataata atttcacatc gtttatcaac aattattgat tcagatataa tatatgtttt
    36901 ctcagaaggt gagattgtag aaagtgatac acattataat ttaatgaaaa aaaaacaggg
    36961 aatttattgc aaattatata cgagtggaat aaaagtacag gtataaatca aaaagaaagt
    37021 tgccaaaatc accagttttc gcattgtctt tcttgctaag catttgtaac tgaaaagaca
    37081 ttacccttta tagaccatgt aaagatgcta aatatgacca tgttgatgaa ttattttcct
    37141 gatatgtggc gtacatgtat caaaacatgg aaattatatg ctaaggatta aaaaaccata
    37201 aagttcttat tttttgtact ttaaagggtg tcaccatggg taaagtgact taaatatggt
    37261 aattatcata agtagtcaaa ataagaaagg tttattacct tgttaattct tcttaataaa
    37321 aactaaagat tatgatcttg ctcttattac attatttgcg gctcaacata ataacgttga
    37381 tttcagaaat attaaataat ctaaagtcaa atattctaat cgaactactt gagcaatcct
    37441 gcactattta attgcatctt atgtgacaac gataatacta tataacatag ctgctactgc
    37501 taatatatcc gttacctctt ttatgtcatt tactattgcg ttcggtatgg ttatctctgc
    37561 acttacatct ctttccgatg tagtaattgt atttgcacag ttttattcaa cggacagaaa
    37621 cagcgaattt aaattgcaag agcaattgtt ttacagccac agatccttat ttttgacaaa
    37681 ggaacttcgt cacttgacaa tataacacag gaaaatttaa ttcattcgct taaaaaattg
    37741 aattgtacta aaattgttgt tgtgcacaga ttatcaacca ttcatcttta tggcaatata
    37801 ataatgctaa ataacgtaca actaatagaa gaaggaacct ataactcgtt gatagacaaa
    37861 aggggaatat tttataactt catattaaga cagcaataca tatagcatag acattaatca
    37921 aaattaagga ggaaatggtg aaaaaaatat ttgcgtatat tggaagccca aaaggaaaga
    37981 attcatatac atggaagtta actaagacca tattggatca agtgatttct ttaagtgatg
    38041 gcgaaattca ttacaagctc atattaccag atcaaataaa gataaatttt tgcgtcggtt
    38101 gcaagtgttg ttttgaaaat ggattttgtc cacaagacac ttctgattca atggaatcta
    38161 ttaaggaaga gatgttgcaa tcagatttaa ttattctggc aagtccggtt tatgctcaca
    38221 atgtaactgg aaatatgaaa gtatttattg ataggattac ttattggatg catatttttg
    38281 gacttgccgg gaaatttgga gtaactattt ctacttctga ctctaatgga aatgaatatg
    38341 taaatagtta tcttaataaa attatgcaat attgtggtct taatgttatc tgccatttta
    38401 aggcaatgca aatgattaac cctctgacta ctaacaatac ttttagtaat cttgatacta
    38461 tgccactaag tcgccttatc tgtgattact taacaaataa tcaccagatg tctgccacta
    38521 gttttcagga aacaatattt caaactttta aaaattacat gttaacgttg gaagaaaata
    38581 acatacaaag ttcagaagtt aaatattgga aagaacatgg atattttgat gctgattcct
    38641 atgatactgt tctctctaag ttgcaagaag aaaattataa aatattagat taacattata
    38701 tcgtctaatc agtatcttgt taaaaaagat aataaaacat tttaaatata atcactagtg
    38761 tttaatcatt aaaaatattg atattgattt taaaaaaagg tatatatatt tctagtaatt
    38821 aattcctaag aaaatctcaa tcactaatgg attagtgatt gagatttttt atatagttta
    38881 aaattaaatt atactgaatt aaatacaata ctccaagaaa atgtatcatt tagatatagt
    38941 tctaatatat tttctttcac ggttctttta atatggggta gtaaccgcta agcgtaaatt
    39001 taccacatta agacacatat taccaaaatg gtgataaatt cagaaagaat attaaatata
    39061 ctcgtgttaa tttaatgttt ttctcaaaga ttttacatta gctaatatat attttttatt
    39121 gttttagtta gcgttatcaa tactatgact gcattttaac aaacttgttt tgagtaaaaa
    39181 aataagagct ttatcattta gtgattaaac cctagatata tcaatgcttt acaatgatgg
    39241 tatatgtttt tttgagttag aactattgcc tattaattct aactcgcaat attcaaataa
    39301 tagtatccaa ctgtaaataa ctggcttagc gttgtaaatt tacgctttgc gagccctacc
    39361 cctaactgat ttaaatggag aattaattga tcaagctatt caagtacact caaaacttat
    39421 gatttcacta cattctaaag gcttaaagct tagggatgaa ctgaatgtaa aaagttcaaa
    39481 atccgcgaat gaaataatgc agattcatgt taaacttgta aaagctatag atactgcgct
    39541 ttcagaaaag aaagatattt caaaagagtt agaaaatcta ggaaaatggg aaatatttaa
    39601 agaaactgca tatagtgctg aaaaaataat acgtccctta aataacgatt atcttgattt
    39661 gttagatagt agttttggta atttaagaaa atattctcca attctcttta aaaatttaga
    39721 atttcatcca tcaaacaatt ctacatcctt aataaatgct gttaatgtca taaaagatat
    39781 gaatgataac aacaaacgga aaattcctga cgatgctcct atagaattta tttcaaaacg
    39841 ctggaaaaat catgtatgta atgaagatgg cacaataaac aaacggtatt atgaaatggc
    39901 agttcttaca gaattaaata atgcaattca ttcgggggac atatggatca gtgacagtaa
    39961 gcagcataaa aatataagca aatatcttat tagcgatgaa gactggaagc gttcctgctt
    40021 aaagaatgaa gcaggtattt ctgtaagttt atcaatagat gagtatttaa aagaacgaca
    40081 agaaacttta ttagacaagt tacaatatgt atcaaaaaac gtgaaaaatc ttgaagatgt
    40141 aagtattgat ggaggtaaaa tttcactaaa aagattagaa aagaatgttt ccgaagaatc
    40201 tgaaaaattt aattctatga tttatggaat gattcctaag ataagtcttc ctgaattgct
    40261 tttagaggtt taagaatgga ctcattttga acaacattta acccatgcat ctacagataa
    40321 gccccctaaa aatgaggaaa tacctatttt gatggcagca ataatggcac ttggtacaaa
    40381 tataggagtt caaaaaatgg cagattcaac atcagatatt acctatgctc aaatggcaaa
    40441 tatatcagaa tggagactcc atgatgatgc ttttaaaaaa gcacaagcta ctcttgtaaa
    40501 ctaccaacac catcttgacc tatcacagta ttttggagat ggcacaactt catcctcaga
    40561 tggtatgcgt gttgaagttg gagtttcctc aatttatgct gataagaatc cacactatgg
    40621 aataggcaag ggacttacta tgtatcgtca tgtaagtgac caatattctg cttatagtat
    40681 agatgtaatt actactaatt caagggattc gctatacttg cttgatggta tattgggaga
    40741 tgaatctgag cttcaaatag agggacatta tactgataca gctggataca cagatcaagt
    40801 atttggatta tttcatttat ttggaattag atttgctcca agaataagag atttatcaga
    40861 atgtgttttg ttttcattta atgatactga ggagttctat aaaacgatta aggatattgt
    40921 taaaggtcgt ataaatctta aatcaataac tgatgattat gaatctgtat taaaattagc
    40981 acattcaata tttataggta aagtttcagc atccttaatc ctagaaaaac taggttccta
    41041 ctcaagaaaa aatagtatgg caaaagcttt aagggagatg ggtgaaatag aaaaaacaat
    41101 atttatattg gaatatatat ctgataaaaa ctttagaaga cgcattcaaa gaggactaaa
    41161 taaaggagaa gctatgaatg ccctgtcaag agctattttc tttggtaaat ttggagaatt
    41221 tagaagaaga gctttacaag aacaactgca aagtgccagt gctttaaata ttacaatcaa
    41281 tgcaataaca atttggaatt gtgtttattt aaataaagct attgatcatc taaagtgtaa
    41341 tggtggattt gacgaaagtc tattaaataa tatatcacca cttgggtgga agcatataaa
    41401 ttttttaggc gagtataaat ttaatttaaa tcaaaatgga aatttaaagg agctaaatct
    41461 ttaaataaaa tgtccttaag cctaaaatgt tacatttatg gggctatatt tttcttagcg
    41521 tacgaaatat cattttcgcg tacgctaccc ctctaatatc ttcataacat caaccacttt
    41581 tattttatct atcaaaaaaa taaagtgaaa gtaacacaat accaattgag ttacattcac
    41641 attgatgcta ttgcttattc aaagcaaaat gaatcttcaa attttttatc taatcaatgc
    41701 aaaatatcaa tgatactttt gcattggatt aaattgattg tttgtttaga aactttttta
    41761 agtcttagtt gcaattattt aaaaacaata tccttagtta taataccgac gctcgttgct
    41821 cttatatgcg gatttatctt taacttctgt aattcctctg gactaccata aaccactacg
    41881 cctattaaat ctactttgtt tgcttttaat tgatccttat tctttagcac agaataaata
    41941 tcactaaact tttttttata agtaatatcc ttaaaattaa attgaagatt atttaaaaac
    42001 ttcccataat tgtttgatac ttcattcgca tcataattaa atccattaga tgtcttaaat
    42061 cctataaaat tgaactcttg aataaatgta gcttttccgt cattttcaga agcttgattt
    42121 ttataaacat tcatttcctt atctgtataa ccatcaatta atagctcaga tatttggact
    42181 ttaggtaaaa tatttgaaac ttcattaatt ttatactttt tatcaaagga taaagtcatt
    42241 tctaatagtg agtcagaact tactttatta agtaaggcta aatcattttt atattccttg
    42301 tatttaatat ctgggtgaaa taccatcata gttaaattgc ctgaaccatc aaaattaact
    42361 ggccattcac cagccttctg tccaccacta cttgaagaca tagtacgatt aatcccatta
    42421 ataaatccta atccataact gctattttga tcatatatat ctacagattt ccaactgccg
    42481 attcttttag agacggtata ttgaccactt gcaccaagaa aaccaataac atcattttcc
    42541 ttgctaatat aagcattagg atttgtaacc tcaagcactt tttccacttg tgtataatat
    42601 ctagttccca ttttaggcgc aatcataaca ttaactatat atagtggtat tatcaataac
    42661 acaactatta taattatccc tccacctttc cttaaatttt tctcttgccc tatagagata
    42721 tgtcttaact gtattttcag ggataccaag taatatagag atttgtttat agcttaaatc
    42781 tacttggtat ttcataagca gtaaattttt atattgctct tttaaatcaa ataatgtttg
    42841 tttaacatat tcacgccttt caactgataa tattgagttt ccaacttcat cctcgctata
    42901 aaaactatta taataacgtt cctcatccaa ataaaaactt aatctattat ttcttttttt
    42961 aaacgttcta aaaatattag tagctactgt aaataaccat gaagggagtt tttctactat
    43021 tacaccatcc atatacaaca tagccctagt aaatgtttct tggacaatat cctcagcttc
    43081 aggctttgaa catccaaggt ttattagata tttgtaaata atactaagtt gatttatata
    43141 tagttgctca ataacatcgt agttcatttt accctcccca ctaaagctac tcatacataa
    43201 gactatcata atgtggaaat gtatacacaa tttatatatt tatttgtata agggtaccgg
    43261 catcaaaacg tgtaaattat agttacacca atcaaatcag ctcaatatta tcctattaac
    43321 tataaaactt actgtatgta agtcgatatt ttaacattct gaaagtaaca caatagtaat
    43381 tgagttactt tcacattggg tctattacct atttcttaaa aatttaattt tgaatgtaac
    43441 ataatgagtt gatttttact ttgaatgtat tataaatgat ctcctaaata tcaaatgctc
    43501 gttgcagttc caccttaatt gctctcttca tattgattaa ttaatttata gaatgtagtt
    43561 ttctttaatt ccaatatttt cataacatca actgctttta tagtattttc cttatacatc
    43621 ttataatact tatcccataa tttcggtact tcaatagact tacgtccttt atatttccct
    43681 tctgatactg caattgatat accttccctc tgtctatctt ttatgtagtc acgttcaagt
    43741 tgtgcaacgg ctccaaacac cgtaagcata aatactcctg taggtgttgt cgtgtctatg
    43801 gattccttta atgatataaa tataacgccc ttactattta attgttctac aagttccaac
    43861 agatctttag tattacgagc gaacctactt atgctatcca caataagctt atcgccgttt
    43921 tttagtgatg ccattagatt agttaacact ggtctttctg ttacgttctt accactaacc
    43981 ctctctatat aaacacattc ccttggtata ttatattctt ttgcctttac ctcttgtcta
    44041 atagtatttt gttcctttga actaactctg atatagaagt atgtttgcat gtaatcacct
    44101 ctttatactt attatattga atcgttcgtt taaagtccat atattatatg aacgatttat
    44161 atgtatattc accaccatat aatgccactt taaaggccat tagttcacgt tcgtctgcgg
    44221 tatatactaa acgaactata ttttgctgaa ttcatcaaag aaataagaaa aatatttctt
    44281 ttgcttataa gaacaaaaaa atcaatataa tatatttaca atatattata taaaacgatg
    44341 cattcagaac aataagcact tagttaaaaa tgaagattta aatcaaattg atgataatat
    44401 aataaaagat tttactaaat atattataca aaaatataaa ttatatcatt gaaaaattta
    44461 ttaaaggttg tagttaaata cataacatac tcaatttatg gtaattatgg tataattaaa
    44521 tgtattttat gacgtacttg taaaataatt cattataaga aaagaaagga tgatgaataa
    44581 tgaaaaaagc tatagctgga attgtagcta ttattatagt ctgtattgta ggaataaaat
    44641 tttcatacag ctccaatttg gggtctatga aagataatat tacttctaaa aaaagcagca
    44701 attctcaaat aacttttaat gctaaaaaag gtgataaagt taaagtt
//
