LOCUS       NZ_CP086140            22100 bp    DNA     circular CON 20-JAN-2024
DEFINITION  Clostridium estertheticum strain CF016 chromosome, complete genome.
ACCESSION   NZ_CP086140
VERSION     NZ_CP086140.1
KEYWORDS    RefSeq.
SOURCE      Clostridium estertheticum
  ORGANISM  Clostridium estertheticum
            Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 5053333)
  AUTHORS   Wambui,J., Stevens,M.J.A. and Stephan,R.
  TITLE     Clostridia strains as spoilage organisms
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5053333)
  AUTHORS   Wambui,J., Stephan,R. and Stevens,M.J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2021) Institute for Food Safety and Hygiene,
            University of Zurich, Winterthurerstrasse 272, Zurich, Zurich 8057,
            Switzerland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2021
            Assembly Method                   :: unicycler v. 1
            Assembly Name                     :: CF016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Nanopore/Illumina miniseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/20/2024 05:10:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,249
            CDSs (total)                      :: 5,114
            Genes (coding)                    :: 5,019
            CDSs (with protein)               :: 5,019
            Genes (RNA)                       :: 135
            rRNAs                             :: 15, 14, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 14, 13 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 22 of 95
            Pseudo Genes (incomplete)         :: 78 of 95
            Pseudo Genes (internal stop)      :: 14 of 95
            Pseudo Genes (multiple problems)  :: 16 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:27:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3867342
            Orig. end                         :: 3889442
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086140.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22100
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="6"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..22100
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22100
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12100](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12100)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    256..270
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 24.94"
                     /tool="antismash"
     misc_feature    complement(1639..1652)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            complement(2111..2404)
                     /locus_tag="LL065_RS18230"
                     /old_locus_tag="LL065_18205"
     CDS             complement(2111..2404)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040910.1"
                     /locus_tag="LL065_RS18230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18205"
                     /product="CD1375 family protein"
                     /protein_id="WP_268064567.1"
                     /transl_table=11
                     /translation="MSNILVKTFLKILLNIYLINKKSSEDNITLIDVLYTRAKSLIVKG
                     GIKMVDMYYRLVKAGLRTIQKVPDQFRDDVMTNLATLTLNKNSKADTNEKYK"
     misc_feature    complement(2376..2387)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    2629..2641
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            2682..2882
                     /locus_tag="LL065_RS18235"
                     /old_locus_tag="LL065_18210"
     CDS             2682..2882
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039785.3"
                     /locus_tag="LL065_RS18235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18210"
                     /product="DUF6440 family protein"
                     /protein_id="WP_226135576.1"
                     /transl_table=11
                     /translation="MFNNNESQNKIPKTIYDHEYEISVRCKAIVNTGLITNYFINIEGY
                     NGGITVLLDKNGNSMLSQIKL"
     gene            complement(3060..3833)
                     /gene="sigG"
                     /locus_tag="LL065_RS18240"
                     /old_locus_tag="LL065_18215"
     CDS             complement(3060..3833)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="sigG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010965003.1"
                     /locus_tag="LL065_RS18240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18215"
                     /product="RNA polymerase sporulation sigma factor SigG"
                     /protein_id="WP_071611726.1"
                     /transl_table=11
                     /translation="MIFNKVEICGVNTSKLPKLKEKEMKELLYRIQNGEPECRDVFIEG
                     NLRLVLSVIKRFNNRGENVDDLFQVGCIGLMKSIDNFNLSLNVRFSTYAVPMIIGEIRR
                     YLRDNNSIRVSRSLRDIAYRALQVRDRLVNENNKEPTVEQIAKELELPREDVVFALDAI
                     QDPVSLFQPIYHDGGDEIYVMDQIKDTKNLDDSWLENISIKDGMNKLKDREKLILNLRF
                     FDGKTQMEVADEIGISQAQVSRLEKTALKHMKKYV"
     gene            complement(4151..4483)
                     /locus_tag="LL065_RS18245"
                     /old_locus_tag="LL065_18220"
     CDS             complement(4151..4483)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="LL065_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18220"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_226135578.1"
                     /transl_table=11
                     /translation="MEKEVNYLKVGSKIRIERERFGMNREYLSGLLDISSYFLGQIERG
                     ERRMSVNTLVNLCECLHISIDSLVFEQVTGNINNDDLHSLINKCSEKEVAVIEGVVKLI
                     LPNLVR"
     gene            4713..5993
                     /locus_tag="LL065_RS18250"
                     /old_locus_tag="LL065_18225"
     CDS             4713..5993
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003385588.1"
                     /locus_tag="LL065_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18225"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_226135580.1"
                     /transl_table=11
                     /translation="MKVIVIGGGWSGCMAAITAKKAGAEVALYEKTDMLLGLGNVGGIM
                     RNNGRYTAAEELIALGTGEFIHVTDENTKHKNINFPGHKNAWLYDVNKIEPAVGRYLKA
                     MDIEVNMITRVVDIKKEDNKIKGIYLSDKSYVAADAFIETTGSAGPMNNCLKYGNGCAM
                     CILRCPAFGGRVSISSKAGIEDLKGEREEEGVYGAFSGSGKLSKGSLANDIVEQLDATG
                     VLIVKVPKEDVNLDKLKLKVCQQYALKEFAENLILIDTGDVKLMTPYYPLEKLRKIKGF
                     ENAKYVDPYAGGIGNSIRYVSIAPRDDSMKVNDLDNLFCAGEKSGLFIGHTEAMATGAL
                     AGYNAVKNCLGMPPLILPRTLAVGDIIAYANEKMQTSEGRKNRYTFAGAEYFKRMKELG
                     LYILDKNEIKSKVENLDLTNIFNKKLI"
     gene            complement(6074..8008)
                     /locus_tag="LL065_RS18255"
                     /old_locus_tag="LL065_18230"
     CDS             complement(6074..8008)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="LL065_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18230"
                     /product="ABC transporter permease"
                     /protein_id="WP_226135581.1"
                     /transl_table=11
                     /translation="MTFNQIAFKIFKANLRRYLLFFLCNSFSIMVFFTYATIYTNKKFM
                     NPSNINYSITNNMVAPGVMVILFSAFFIFYAQNSFIKFRKKEFGLFMVLGMINKNIQRM
                     MIIENGLIAIFSLLTGLVSGTIFSKLFYMLIIKIIDVKGVPFSIAIQSYIYTAIFFTVI
                     YLLVIIKGLIESFRYEIINLLKSTRKQDNNFLNSPIWSVIGIILIVIACCDMIINNSVE
                     SSSVSLRSLAVCFLGIYLLISNMAWLFSKVTNYFHHKSFKNILFIANMKHTLGQSKKIL
                     FIITLFVSMTIFMSTIAVILVADSKRMSTAYNPYDIAYAEIFGKNKITAPQLDNILKNS
                     NTNLTSLKSIDFISKTYITILSDKNLNANLGTQLKVEKGCFISLFQIVKDDGYEHDTTA
                     ISSLVIPIKGTDNKYKPGGKITKVLFNNIPILSNGHYVILNNNDFQNIRTNSKQNDVGT
                     IKLMNFNDWYKTKEVLDELKSNLETSNRKNKTYFENINDDIKWFKPASRIADYLDEKQS
                     GSYSLFLCSFVGILFFISSVVMLHFKLLTEYDNEKIKYKKLYKIGITDNEVAKLISKEL
                     KVLFFMPYILSFFVSAFYSYHLPVKQGGQMVTLMYSLIISLIYFCFQIVFYLVYNKVYV
                     KRLIKDLEK"
     gene            complement(7998..8762)
                     /locus_tag="LL065_RS18260"
                     /old_locus_tag="LL065_18235"
     CDS             complement(7998..8762)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963695.1"
                     /locus_tag="LL065_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18235"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_226135582.1"
                     /transl_table=11
                     /translation="MSVLNANNVVKIYKGLGKSNSTKALNGICLTIENGEFVAIMGPSG
                     SGKTTLLNILSGIDKLTSGDIEISGQNINVMTKDELALFRRQHLGFVFQEFNLLDSLTL
                     KENVMLPMILDDKEPEDIQIKADEVMSMFNIEDIMEKYPYTVSGGQQQRTAISRAIINN
                     PDIIFADEPTGNLDSKSSKNVMKCFEKLNTINKNTVLIVTHDSFAASFCNRVIFIKDGL
                     VNMEIRKEGTRKDFFDNILGCLALIGGEEDDL"
     gene            complement(9016..9177)
                     /locus_tag="LL065_RS18265"
                     /old_locus_tag="LL065_18240"
     CDS             complement(9016..9177)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003358818.1"
                     /locus_tag="LL065_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18240"
                     /product="hypothetical protein"
                     /protein_id="WP_226135583.1"
                     /transl_table=11
                     /translation="MVAHRQNITVDPIVYEDFCKYAKMKGMKISTWVAMKMKEAVEEEK
                     EIEKRNHL"
     gene            complement(9177..9536)
                     /locus_tag="LL065_RS18270"
                     /old_locus_tag="LL065_18245"
     CDS             complement(9177..9536)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017209583.1"
                     /locus_tag="LL065_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18245"
                     /product="hypothetical protein"
                     /protein_id="WP_226135584.1"
                     /transl_table=11
                     /translation="MGKIENCSKCSCELCSVINADPVDMEKHGARLLTVRIRVNNVCFD
                     KKVAVAVIIYDNCHRILAFRGFITVVCKENECGDECGTIVRKLVFVLPDDDSSNPDELE
                     VRTAANYIFPCESNC"
     misc_feature    9739..9752
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.07"
                     /tool="antismash"
     gene            complement(10001..10570)
                     /locus_tag="LL065_RS18275"
                     /old_locus_tag="LL065_18250"
     CDS             complement(10001..10570)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241559.1"
                     /locus_tag="LL065_RS18275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18250"
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_226135585.1"
                     /sec_met_domain="AgrB (E-value: 2.9e-37, bitscore: 125.9,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKLICCIVKEISKTNSQFTDLELKKMEYGLLCFFDEVTKIIPYY
                     IIFHLFSLQQYYMVEFVFFCPIRLFSGGFHARTYWGCFLISFLTFCVIIFIGKYLTINV
                     FTSLLVLIISVLLVCIFSPVDNINKRIKSKERRNKLKNISVIIIFLLSVLSYLIPSRFF
                     TTAVTAILIAVILMMAGYINNGLTKK"
     gene            complement(10585..11889)
                     /locus_tag="LL065_RS18280"
                     /old_locus_tag="LL065_18255"
     CDS             complement(10585..11889)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017750982.1"
                     /locus_tag="LL065_RS18280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18255"
                     /product="ATP-binding protein"
                     /protein_id="WP_226135586.1"
                     /transl_table=11
                     /translation="MTREIILDILEALLLLGVFSSLTNEKKYIVTNKLKSGLFCILYVC
                     ATSLSTFYVNNLYHTLTNIVVSILLLKLITKISLYLSTIIFSLFFTIIFTTETFVQFIE
                     IFLLKVNLNQILTVNKYLFIFLILCKFLQIVIVILLLKFALYFKDILLNDEKSLFSEFL
                     IQIGIFNLFIYILIFSVLNIKSNKIYNMLIYSIFFVFSIIAVLYLKEREKMININNKYK
                     IQKHQISNMEEIMSIIRQEKHDYANHINVIQALCCLNKPNAVEKIKEYVSKISDTIHTS
                     FTYLNTGNDYIDGLLSIKNNYAMKNKIDFNVIIDESFNFLKIREDELISIISNIIDNAF
                     EAFKLKSCIENKEISITTYLENTTFCIEIANNGERIPEEIKNKIFEKGFSTKTKQEGDN
                     GFGLYITKQLVEHNNGNISVERVSGKTKFLVEFKM"
     gene            complement(11969..12100)
                     /locus_tag="LL065_RS18285"
                     /old_locus_tag="LL065_18260"
     CDS             complement(11969..12100)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015615663.1"
                     /locus_tag="LL065_RS18285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18260"
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_309249357.1"
                     /sec_met_domain="TIGR04223 (E-value: 1e-05, bitscore: 23.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLIRKTMKMIGCVALFVGALAIVPTSLINSHQPNCPDEFLL"
     gene            complement(12325..12465)
                     /locus_tag="LL065_RS26370"
     CDS             complement(12325..12465)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014898.4"
                     /locus_tag="LL065_RS26370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /protein_id="WP_326493069.1"
                     /transl_table=11
                     /translation="MGGLFLWKKLMNYCQSKNLSQKTMMSYEQTLRLFSKYLQGEKNSK
                     R"
     gene            complement(12615..13433)
                     /gene="spo0A"
                     /locus_tag="LL065_RS18290"
                     /old_locus_tag="LL065_18265"
     CDS             complement(12615..13433)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /GO_process="GO:0042173 - regulation of sporulation
                     resulting in formation of a cellular spore [Evidence IEA]"
                     /codon_start=1
                     /gene="spo0A"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007060005.1"
                     /locus_tag="LL065_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18265"
                     /product="sporulation transcription factor Spo0A"
                     /protein_id="WP_226135587.1"
                     /transl_table=11
                     /translation="MEEKKINIIIVDDNKEFCNILNDYLLTQKDIVVTGIAQNGIEAIK
                     LIEEKKPDLVVLDIIMPILDGLGVLERLNTMEIQPRPRIIILSAVGHEKITQRAISLGA
                     DYYVIKPFDMEVFANRIRQTLNENICNDETPKTLSYAGNDEIKTNRSKPVDVDMIGQIT
                     SIIHEIGIPANLKGYMFVREAINMVVNDIDLLSSVTKELYPLVGEKFNTTASRVERAIR
                     HAIEVAWNREQVETITNLFGYTINNEKGKPTNSEFIAMVADKLRLQNRVS"
     gene            complement(13765..14955)
                     /locus_tag="LL065_RS18295"
                     /old_locus_tag="LL065_18270"
     CDS             complement(13765..14955)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (36-381). E-value:
                     2.8e-54. Score: 176.6. Matches aSDomain:
                     nrpspksdomains_LL065_RS18295_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422792.1"
                     /locus_tag="LL065_RS18295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18270"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_226135588.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.2e-52, bitscore:
                     176.5, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.5e-06,
                     bitscore: 23.5, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISSKMKDLVANSSIIRAMFEEGKRLSDIYGEENVFDYSLGNPNV
                     APPENIKVEINKILNEIAPKLVHGYMNNSGYEDVRGKIAEFLNKKHNIDISYNNIVMTC
                     GAAGGLNILLKTLLNPEDEVIVFAPFFGEYRNYVNNFDGKLVVVSTDIDTFEPNMESLK
                     DKINSKTKAIIINSPNNPTGVVYCEKVIQDLANLMNQKQDELGTSIYLISDEPYREIVY
                     DNVVVPYILKYYTNSFIGYSYSKSLSLPGERIGYVVANTKMDCFDDIMISLNVANRILG
                     FVNAPSLFQRVIANCLEAEVDVSIYQKNRDLLYNYLTKIGFVCVKPQGAFYLFIRTPIK
                     DDKKFCEDAKEFKLLLVAGSAFECPGHARLSYCVDYKKIENSLPAFEKLAKSYNLK"
     aSDomain        complement(13813..14847)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LL065_RS18295_Aminotran_1_2.1"
                     /evalue="2.80E-54"
                     /label="LL065_RS18295_Aminotran_1_2.1"
                     /locus_tag="LL065_RS18295"
                     /protein_end="381"
                     /protein_start="36"
                     /score="176.6"
                     /tool="antismash"
                     /translation="DYSLGNPNVAPPENIKVEINKILNEIAPKLVHGYMNNSGYEDVRG
                     KIAEFLNKKHNIDISYNNIVMTCGAAGGLNILLKTLLNPEDEVIVFAPFFGEYRNYVNN
                     FDGKLVVVSTDIDTFEPNMESLKDKINSKTKAIIINSPNNPTGVVYCEKVIQDLANLMN
                     QKQDELGTSIYLISDEPYREIVYDNVVVPYILKYYTNSFIGYSYSKSLSLPGERIGYVV
                     ANTKMDCFDDIMISLNVANRILGFVNAPSLFQRVIANCLEAEVDVSIYQKNRDLLYNYL
                     TKIGFVCVKPQGAFYLFIRTPIKDDKKFCEDAKEFKLLLVAGSAFECPGHARLSYCVDY
                     KKIEN"
     gene            complement(15068..15904)
                     /locus_tag="LL065_RS18300"
                     /old_locus_tag="LL065_18275"
     CDS             complement(15068..15904)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015392315.1"
                     /locus_tag="LL065_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18275"
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_226135589.1"
                     /transl_table=11
                     /translation="MRIGIRGHDIGQYKLDELAAILEGKNIKSIQFVLKKIITEFKITS
                     GSMTPGMAEHIKGILTKHNLNISLLGCYINLANPDDNELNKLLENFKEHIRFAKYLGCN
                     IVGTETGALNREYVYTKDNNTEEAFKRSLSSIKILVKEAEKFGVVVGVEGVTKHVMNTP
                     ERLKRAIDCVNSNNLQVIFDPINFIDETNFDKQDEIIKKSFELFGDKIAIIHAKDFIYD
                     DGKVKQVSIGSGQFNYPLLLSLIKERKPYIDIILEDTVPTDLDSSIKYIEELYKKI"
     gene            complement(15979..16737)
                     /locus_tag="LL065_RS18305"
                     /old_locus_tag="LL065_18280"
     CDS             complement(15979..16737)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009168192.1"
                     /locus_tag="LL065_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18280"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_216171728.1"
                     /transl_table=11
                     /translation="MLPIERLEIIKQIVLTEKKLYVSKLSQKFNVTEETIRRDLEKLKV
                     QGIVTRSYGGAILNAERTIDDVPFYKRSKTNIDNKKYVASKAIEFIKEDSTIVADCSST
                     VLEVLKLIRDRSGVTIITNSVGVLSELNKSSLNIILTGGVIKRRSLSMQGPITHCTIKK
                     YSVDLALVSCKGMDIEKGVLDANEEEAEIKRIMIKQANTVIMLIDHDKYDKTSFVKLFD
                     YEDIDYIITDQEPRAEWMELLHSYNIDVIY"
     gene            complement(16879..18426)
                     /locus_tag="LL065_RS18310"
                     /old_locus_tag="LL065_18285"
     CDS             complement(16879..18426)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011967800.1"
                     /locus_tag="LL065_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18285"
                     /product="MFS transporter"
                     /protein_id="WP_226135590.1"
                     /transl_table=11
                     /translation="MSQKDGKIRFINYFSYGMNDFIGAGAFALTSAWLLYFYTTFCGLS
                     PIQAASIFALARVVDAVASPTMGFITDNFHKTKLGKRFGRRKFFLLLAIPLVGVYTTIW
                     ISGFTYFYYLATYIAFELVYTMILIPYDTLAAEMTSDFKVRAKLTSARMYIAQFSAFLA
                     AFIPGRLINLLGKESPKSFLYAAMIFTVIFVIVLILVYTFTWERPLAEIEAAEASEVKE
                     KLTFMQNVQKIYVDLVTTLRIRTFRAHLGMYIGGYLAQDTFNAVFTYFVVFALFQNVIM
                     ASNLIAVMYIFQIAGVGIATYLTLKLNPGAAFRVVSSIFIISIIGYLIVYKTIPTSIIA
                     LYAVSCIAGLGRGGINFVPWNNYTFVPDVDEIVSGDRREGVFAGFMCFLRKASQALAIF
                     LVGVALEEAHFVSGVKTQPQEALNIMVVILIVAPIIFLIIGIISSFKFTVTRESHAILK
                     KEVKRLKTGGSKADVDEKTRKTVEELTGWDYEKLWGNNPVGYKNWKKCKAKEKQASM"
     gene            18782..19903
                     /locus_tag="LL065_RS18315"
                     /old_locus_tag="LL065_18290"
     CDS             18782..19903
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011967798.1"
                     /locus_tag="LL065_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18290"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_226135591.1"
                     /transl_table=11
                     /translation="MKLTEKEIRIKLDLVVNKLINLDSPSVEEKLPKEGGEAIGLFPRD
                     FGIQEWDWPQGVGLYGLLKLDKHDKSDKYLDFLTNWYKTNIEIGLPSKNINTTAPLLTL
                     VNLCDVINNPEYENLCLTWADWLINCLPRTKEGAFQHVTSANGDRQAVRLNESEMWIDT
                     IFMTLLFLNKMGQKYNRKDWVNESINQMLVHIKYLYDKKSGLFYHGWSFNENSNFGEVF
                     WCRGNSWFTFGILDYIEAFEGTMNPGIKKFLLDTFKSQVNTLVKYQAESGLWHTVIDDV
                     TSYEEVSGSAAIVTGILTGIRLGILDDSFKPYAEKTIKALCNNIEKDGTVLKVSGGTGM
                     GYNVDHYKNIIIAPMAYGQSLTIMALVEALNHL"
     gene            complement(19961..20575)
                     /locus_tag="LL065_RS18320"
                     /old_locus_tag="LL065_18295"
     CDS             complement(19961..20575)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012160529.1"
                     /locus_tag="LL065_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_18295"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_226135592.1"
                     /transl_table=11
                     /translation="MDEQKLNNRQLQALNTKNKIYKSAIDLMDKKGYKNIKIQDICKKA
                     GVSVGSFYNCFKSKNEILIEIYKRADEYFITEVANNIYCDNATNEIIKYFDYYAKYNVQ
                     VGIDTMKLLYNSNNKLFITKGRDMQNLLNIIIERGQEKNELSNEMSKESITEYLFIAAR
                     GVVYNWCLYDGEFDLLEAMNEYMKRFIIIFKYENSIKQKNS"
     misc_feature    20753..20767
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 24.71"
                     /tool="antismash"
     misc_feature    complement(20936..20950)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.81"
                     /tool="antismash"
     misc_feature    complement(21465..21474)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 14.43"
                     /tool="antismash"
     misc_feature    21927..21940
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.06"
                     /tool="antismash"
ORIGIN
        1 tgattttgat aaaattccag agatgcttca acatctttca gaagttgata gtcaaaatta
       61 tagctacgaa aaaacactta aacgtataaa gaaatataca cagattctaa actcaccgta
      121 ttttggaaga tttgatttta aagaagatgg ttatgatgat tttgataaaa tttatattgg
      181 tctttataat ttaatagata aagataccag ttcaatttta atatatgatt ggcgctcacc
      241 tatttcaagt atgttttatc aatttgaaat aggcaaaggc tcatataatg cgccattctc
      301 agtgatttca ggtgatatta ttatgaagag acaatataaa attaaggact ccaaacttca
      361 atattttttt gatagtagtg taacaattaa tgatgatatt ctgcaagaag ttttgagcca
      421 taattcttca tcaacaatga aaaatatagt tgaaaccatc caaaagcagc aggatataat
      481 tattcgcgat actgaaaacg aacttttaat tgtgcaaggc gtcgctggaa gtggtaaaac
      541 ttctatagca ctacatagaa ttgcatattt gctttatgtt ggtatgggat caaaaataca
      601 ttccaataat attattataa tttctccaag ttccgtattt agtaaatata tttctggggt
      661 tttaccagaa ctcggcgagg ataacgtaga agaaactact tttgacaata ttatagttga
      721 tttcttagat aatagattta tatttgaaag taggaaagaa caacttgaat ctttgattat
      781 taataataat caaaccataa atataaaatt ggagaacact aaatttaaag gctcaaaaac
      841 ttttgttata attttagata gactaatcta ttattatgaa cataatttga ttaattttga
      901 agacttatat tatgatggca aaattattga aacaaagcag cagctaaata atcttttctt
      961 aaacggtaaa atggatatgc caatatcaaa aagacttaaa agaattgaaa gtatgatgct
     1021 taataaaatt caccctttaa gaaaagcaag gcttcaaaag attcaaaaga ttattctaaa
     1081 tagtactaac caccagttag agataaaatc ttttagcaga ttaatggcaa ttaaagaagc
     1141 taaagtatta atgaatcata ttcacaagta tacgcaggtt gattattcaa atttgtataa
     1201 attacttttc aataaaaccg gacttttttt taaactttcc aaagggttag agctaccaaa
     1261 agaaataaaa caaatgttat taaaaaccgc tgaaaatctc cataaaggcc atattaatta
     1321 tgaggattgt gcaccccttt tatatattaa acttaaactt aatggtaatc gggaattttc
     1381 agatatacag caggttgtca ttgatgaggc tcaagattat tatccccttc aatatgaagt
     1441 ttttaatctt ctatttgcta gagctaaatt tacaatatta ggtgacttta atcaaactct
     1501 tgaaaagcac ggtaataaat ttatttatga tgatctagaa aacattctta ataagaaaaa
     1561 aagtctaaaa ctttccatga ataaaagctt tagatcctca attgagatta attcatttac
     1621 tcaaaaaata ttaaatagca aagaagagtt tgtttccttt gataggcatg aagatgaacc
     1681 aataattgta ttcaaagata atgagaagtc tatttatgaa actatcatac tagatattca
     1741 caaatacgaa agtcttggtt atgaatctat tgcagttatt tgtaaaacgc agcaagaagc
     1801 actaataatt gaaaaagaat taattagttt agataacatt aaattattaa atatagatga
     1861 cactgaaatt ataaagggca ccgtagttat tccatcctat atatcaaaag gtctagaatt
     1921 cgatgtagta ctagttttca atgtttcaaa aaaaaattat aatagtgaat tcgataggaa
     1981 tcttttatat gttgcttgca caagagcact ccatcaactt gttatttatt ataccggaga
     2041 aaaaagtgat tttttttaaa ttataataaa aaaaaataga taaaggctat ttaaagtctt
     2101 tatctgttta ctatttatat ttctcgttag tatccgcctt gctatttttg ttcaatgtta
     2161 atgtcgccaa atttgtcata acgtcatctc taaactgatc tggtactttc tgaattgttc
     2221 ttaagcctgc tttcacaagt ctgtaataca tatcaaccat ttttattcct cctttcacta
     2281 ttaagctttt ggcccttgta tataaaacat ctattaaagt tatattatct tcacttgatt
     2341 ttttattaat tagataaata tttaaaagta ttttcaaaaa cgttttcact agtatattac
     2401 tcatataact atatccgatg ttctatataa tattatttac aaaattcatt aatttataca
     2461 tttattagat tatttttttc tttaagatta ttgtaaaaaa aacaccatta tataattaag
     2521 gcatatatta atattaatag ctaaaacaaa gatatctgta ttctattaaa tattcctcaa
     2581 attgaataaa caaaacttaa ctaaataaag atttatgaat gactaatgat gcatttggca
     2641 ataactttat aatataagtt cttaaaatat aggagggaaa aatgtttaat aataatgaga
     2701 gtcaaaataa aatccctaaa acaatatatg atcatgaata tgaaatatcc gtacgttgca
     2761 aagcaattgt aaatacaggt ttaataacaa attattttat aaatatagaa ggttataatg
     2821 gaggcattac tgtattgtta gataaaaacg gtaactctat gttatcgcaa attaaattat
     2881 aatatcccac aaaattaaat ttcggctaac cataacatag tataagtttt aataaaaatt
     2941 ataaaaaagc acctatagaa aaacaccgtt aaatcgtgtt ttcctgtaag tgctaattta
     3001 attagatccc ttttaacatt tctaaaacac aaatataaaa ctgttcctgc tagaggaccc
     3061 tatacatact ttttcatatg ttttaatgca gtcttttcta gtcttgacac ttgtgcttga
     3121 gaaataccta tttcatcagc tacttccatt tgggtttttc catcaaaaaa tctcaagttt
     3181 aatattaatt tttctctatc ttttaatttg ttcattccat ccttaattga tatgttttca
     3241 agccaactat catctaagtt tttagtgtct tttatttgat ccattacata aatttcatct
     3301 ccaccatcat ggtatattgg ttgaaacaaa gatacagggt cttgtatagc atctaaagca
     3361 aataccacat cctcccttgg taattctaac tcctttgcaa tttgttctac agtaggctct
     3421 ttattgttct catttaccaa tctgtcccta acttgtaatg ctctgtatgc aatatcccga
     3481 agtgacctac taactcttat agagttatta tctcttaagt atcttcttat ttcccctata
     3541 atcataggaa ccgcatatgt tgaaaaccta acatttaaac ttaaattaaa attatcaata
     3601 gatttcatta aaccaataca gccaacttga aatagatcat ctacattttc tcctcgatta
     3661 ttaaaacgct ttattacact taaaaccaat cttaaatttc cttcaataaa tacatctcga
     3721 cactcaggct cgccattttg tatcctgtac aataactcct tcatttcttt ttcttttaat
     3781 tttggtaatt ttgaagtatt taccccacat atctctactt tattaaatat cataaggtca
     3841 tcattccctt caatgtaatt gcttttaaat tatgtcctta agatttattt attatactaa
     3901 agacaaccct ataatatttt tttaaatttt cccttaaaca ctttaatttt tttccacagc
     3961 tattcatgcc tttaatttga gtacatgtag caggttttag aaacatttaa taaccattat
     4021 taataataaa aaatagccat tctcttaaag agaataacta ttaactatcg cgtactttat
     4081 tcctacgcta tactatatga tatgcacaga atttttaaaa attccataat taaaatattc
     4141 attatatttc ttaccttaca agattgggca aaatcagctt tacaactcct tcaataacag
     4201 caacttcttt ttctgagcat ttattaatta atgaatgcaa atcatcatta tttatatttc
     4261 cagtcacttg ttcaaaaacc aaagaatcta tagaaatatg tagacattcg caaagattta
     4321 ctaatgtatt aacactcatc cttctttccc ctctttcaat ttgccctaaa aaatacgaag
     4381 atatatctaa gagtcctgac aaatattctc tattcatacc aaacctttct ctttcaattc
     4441 ttattttgct acctactttt agataattaa cttccttttc cataatatcc tccctagtaa
     4501 tcttcatatt atctaccaat taggttagtt atatcactat atcatatttc atattgttct
     4561 gtatcctttt aatattacta catatctcga tataaaaata tcaataacga atattcataa
     4621 cagtaataat actataacta ttgcaataga ataaacgtaa caaaacaaaa tgcagaagat
     4681 cctaaatatg cattagaagg gtggcaaata ttttgaaggt tatagtaatt ggtggtggat
     4741 ggtctggttg catggctgcg atcacagcaa aaaaagctgg tgcagaagtt gccttatatg
     4801 agaaaacaga tatgctttta ggtcttggta atgtcggtgg tataatgaga aataatggtc
     4861 gctatactgc agctgaagaa ttaatagcat taggaacagg agagtttata catgtgactg
     4921 acgaaaatac caaacataaa aatattaatt ttccaggtca taaaaatgct tggctttatg
     4981 atgtaaacaa gattgaaccc gcagttggaa gatatttaaa agccatggat atagaagtaa
     5041 acatgataac aagagtagtt gatattaaaa aagaagacaa taaaataaaa ggtatatatc
     5101 tatcagataa aagttacgtt gccgctgatg catttataga aactacaggc tcagctggtc
     5161 caatgaataa ctgcttaaaa tatggtaatg gatgtgcaat gtgcattctt agatgccctg
     5221 cctttggtgg gagagtaagt ataagtagca aagcaggtat tgaagattta aaaggtgagc
     5281 gagaagaaga gggtgtatat ggtgcattta gtggttctgg caaactatct aagggttcct
     5341 tagctaatga tatagttgaa caattggatg cgacaggcgt gcttattgta aaggttccaa
     5401 aagaagatgt aaatttagat aaacttaagc taaaggtatg tcagcaatat gccctaaaag
     5461 aatttgctga aaatttaatt cttatagata ccggtgacgt aaagcttatg accccctatt
     5521 atccattaga aaaattgaga aaaatcaaag gatttgagaa tgcaaaatac gtagacccat
     5581 atgcaggtgg aataggaaac tccatcagat atgtgtccat agctccaaga gatgacagta
     5641 tgaaggttaa cgatttagat aatttgtttt gcgctggaga gaaatcaggt ctatttatag
     5701 gccacactga agcgatggca acaggagctt tggctggata caacgccgta aaaaattgct
     5761 taggaatgcc tccactaata ttgccaagga ccctagctgt aggtgatata atagcttacg
     5821 caaatgaaaa aatgcaaact agtgaaggaa gaaaaaacag atataccttt gcaggagcag
     5881 agtattttaa aagaatgaag gaactaggac tttatattct tgataagaat gagattaaat
     5941 cgaaagtaga aaatttagat ttaaccaata tatttaataa aaaacttata tagataaaaa
     6001 tcaaaaaaga tcagaattaa aagtctgatc ttttttgatt gttatttatt aagaattcca
     6061 cctaagtcca tttttatttt tctaaatcct taattaatct ttttacatac accttattat
     6121 aaactaaata aaatactatt tgaaagcaaa aatatataag actaattata agagaataca
     6181 ttagcgtaac catctgacct ccttgtttaa ctggcaagtg gtagctataa aaagctgata
     6241 caaaaaatga taatatgtac ggcataaaaa ataacacttt taactctttt gaaataagtt
     6301 tagctacctc attgtcagta attcctattt tatatagttt tttatatttt atcttttcat
     6361 tatcatactc tgtcaaaagt ttaaaatgca acattaccac tgacgatatg aaaaaaagta
     6421 ttccaacaaa gctacataaa aacaatgaat atgaccctga ttgcttctca tccaaataat
     6481 cagctattct tgatgcgggt ttaaaccatt taatatcgtc atttatattt tcaaaataag
     6541 ttttattttt tctattactt gtctccaaat tacttttcag ctcatctaaa acctctttag
     6601 ttttatacca atcattaaaa ttcataagct taattgtacc tacatcattt tgtttagaat
     6661 tagttcttat attttggaag tcgttattat taaggataac ataatgccca ttactcagta
     6721 ttggaatgtt gttaaatagt actttagtaa ttttccctcc aggtttatat ttattatcag
     6781 taccctttat cggtataaca agactgctaa ttgcagtagt gtcatgttca tacccatcat
     6841 cttttactat ttggaatagt gatataaaac atcctttttc aacttttaac tgtgttccca
     6901 aattcgcatt tagattttta tcagataata ttgttatgta tgtttttgat ataaaatcta
     6961 ttgattttaa agaagttaaa ttagtattag aattttttaa aatattatca agttgaggag
     7021 ctgtgatctt gttttttcca aaaatctctg catatgctat gtcataagga ttgtacgcag
     7081 tggacattct cttagaatcc gctactaata ttactgctat agtactcata aatattgtca
     7141 tgctaacaaa taaagttatt ataaagagga ttttctttga ttgacccaaa gtgtgtttca
     7201 tattagctat aaataaaata tttttgaaac tcttatggtg aaaataatta gttaccttcg
     7261 aaaaaagcca agccatatta gaaattaaaa ggtaaattcc taaaaaacat actgccaaac
     7321 ttcgtaatga tactgatgag ctttccacgc tgttattaat aatcatatca cagcaagcta
     7381 ttactattag gataattcca attacactcc agattggact atttagaaag ttattatctt
     7441 gttttctagt agattttaaa agatttatta tctcatacct aaaagattct ataagtccct
     7501 ttattattac aagtaagtaa atcaccgtga aaaaaattgc agtgtaaata taactttgaa
     7561 ttgcgataga aaaaggtacc cctttgacat caattatttt aataattagc atataaaata
     7621 actttgaaaa tattgttcct gaaactaatc ctgttagtaa cgaaaaaatt gctattaagc
     7681 cgttttctat aatcatcatt ctctgtatat tcttatttat catgcctaac accataaaaa
     7741 gtccaaattc cttttttcta aatttgataa aagaattctg agcataaaat ataaaaaatg
     7801 ctgaaaaaag aataaccatt actccaggag ctaccatatt atttgtaata gaataattaa
     7861 tatttgaagg attcataaat tttttatttg tataaattgt agcatatgta aagaaaacca
     7921 ttattgaaaa gctgttgcat aaaaaaaaca gtaaatatct tctcaaatta gctttaaaaa
     7981 ttttaaaagc tatctggtta aaggtcatct tcctcacctc caattagtgc aaggcaaccc
     8041 aatatattgt caaaaaaatc ctttctagta ccctctttcc taatttccat gtttacaaga
     8101 ccatctttta tgaaaatcac acggttacaa aaactggcag caaaagaatc atgtgttact
     8161 attaatacgg tatttttatt tatagtattt aatttttcaa aacacttcat tacattcttt
     8221 gaagattttg aatctaagtt tcctgtgggc tcatcagcaa atattatgtc tggattattt
     8281 attatagctc ggcttatagc tgttctttgt tgttgacccc cagaaacagt atatggatat
     8341 ttttccatga tgtcttctat attaaacatt gacataactt catctgcctt aatttggata
     8401 tcttctggtt ctttatcatc tagtatcatc ggtaacatga cattttcttt tagtgtaagg
     8461 ctatctaata aattaaattc ttgaaaaaca aaacccaaat gttgacgtct aaagagagct
     8521 aattcatctt ttgtcatcac atttatattt tgccctgaga tttcaatatc accagatgta
     8581 agtttatcta tcccacttag aatatttaaa agtgttgtct ttccactacc agagggtccc
     8641 attatcgcaa caaattcacc attttcgatt gtaagacaaa taccattaag agcttttgta
     8701 gaatttgatt tacccaatcc tttgtaaatt ttcactacat tattcgcgtt taaaactgac
     8761 atttatatct ccccctaata tcactcactt caacttttta taatttttta tttaattata
     8821 ccattattta cttaaattgt aatgacagcc ttcccctcat tctttgcttt tggatcaaat
     8881 ataaaccaat aagtataata tatgtactat attttataaa aacagacctc cctatttatg
     8941 gtataaaaca cccaataaat agaaaggtct ataactttaa atgtccttag ttagtttttt
     9001 taatagtatg ctcttttata agtgatttct tttttcaatt tctttctctt cctctactgc
     9061 ctctttcatt ttcatagcca cccatgtaga aattttcata cctttcattt ttgcatactt
     9121 gcaaaagtct tcatatacta ttggatcaac agttatattt tgtctatgag caaccattaa
     9181 caattagact cacatggaaa tatataattg gctgctgtac gaacttcaag ttcatcaggg
     9241 ttactactat catcatctgg aagtacaaac actagttttc gtacaattgt accacattca
     9301 tctccacatt cattttcttt acataccact gtaataaaac ctctaaatgc aagtattctg
     9361 tggcaattgt catatattat aactgcaacg gctacttttt tatcaaaaca tacattgttt
     9421 actcttattc ttacagttag taatctagcg ccatgtttct ccatatctac tggatctgca
     9481 ttaataacac tacataattc acatgaacac ttgctacaat tttcaatttt acccatttaa
     9541 taaaactcct ttttatatat aaattttaaa taagacacta cttattaata ctgatctcgt
     9601 catcaagaat tttatagcta catatatcac tataatatat tttcaacata agacttatac
     9661 gttgatatat gttctactaa atcagattaa tattttgaat tgcctccatt ctaaatttaa
     9721 aagtttaatt aatgggattg gatagaatat aaataatgta tattctacac tactaatgta
     9781 ttcataataa gtctaaatgt gaatgaaagt ggtactctaa agaaattaat tttttaaatt
     9841 acggcttcaa agtttttgaa tattttcaat gtatagttaa taaaaatata aatcaataaa
     9901 cacattccca tattgtaata tatattatta ctaaaaatat atagtaatga tgggtaaaaa
     9961 aataatgagc ttatcaattc agctcattag ttgtaattat tcatttttta gttaatccat
    10021 tatttatata acccgccatc atcaatatta cagctataag aatagctgtc actgccgtag
    10081 taaaaaatct acttggtatt aaataactca atacactcaa cagaaaaatt ataattactg
    10141 aaatgttttt gagtttattt cttcgttctt tgctttttat tctcttatta atattatcta
    10201 caggagaaaa aatacaaaca agtaaaacag aaataattaa tactaataac gatgtaaaca
    10261 catttatcgt taaatattta ccaataaaaa ttattacgca gaaagttaga aaactaataa
    10321 gaaaacatcc ccaataagtc cttgcatgga atccacctga aaacaatctt attggacaga
    10381 aaaatacaaa ttcaaccatg taatattgtt gcaatgaaaa caaatgaaat ataatataat
    10441 atggaataat cttagtaact tcatcaaaaa aacagagtaa tccatattcc atttttttta
    10501 attctaagtc tgtaaattgg gaatttgttt ttgagatttc ttttactata caacagatta
    10561 atttattcat tggtctatat cctcttacat cttaaattca actagaaatt tggtttttcc
    10621 cgaaacacgt tctacagata tgttcccatt attatgctcg actaattgtt tagtaatata
    10681 tagcccaaat ccattgtcac cttcttgctt cgtttttgta gaaaaccctt tttcaaaaat
    10741 tttatttttt atttcttccg gaattctctc tccattattt gctatttcga tacaaaatgt
    10801 tgtattctct aaataagtag taatcgatat ttccttattt tcaatacatg attttaattt
    10861 gaatgcttca aatgcattat ctataatatt actaataata cttattaatt catcttccct
    10921 aatttttaaa aaattaaagg attcatcaat tatcacatta aaatctattt tatttttcat
    10981 tgcatagtta ttttttattg ataacaatcc atcgatataa tcatttcctg tatttagata
    11041 tgtaaatgat gtatgaattg tatccgaaat ttttgataca tattctttta ttttctcaac
    11101 agcattcggt ttgtttaaac aacataatgc ttgtataaca ttgatatggt tagcataatc
    11161 atgtttttct tgtctgatga tgctcattat ttcttccata ttagaaattt ggtgcttttg
    11221 aattttatat ttgttattta tatttatcat tttctctctt tcttttaagt atagaactgc
    11281 aattattgaa aatacaaaaa atatgctgta aattaacata ttatatattt tattactctt
    11341 aatgtttaac acactaaaaa ttaaaatgta tataaataga ttgaagatac caatttgtat
    11401 tagaaattca gagaaaagag atttttcatc attaagcaat atatctttaa aatataaagc
    11461 aaattttaaa agtaatataa caatcactat ttgtaggaat ttgcacaaaa taaggaagat
    11521 aaataagtat ttattaactg ttaaaatttg atttaaattc actttaagta aaaatatttc
    11581 aatgaactga acaaaagttt ctgtagtaaa gattattgta aaaaacagag aaaatatgat
    11641 agtagataaa taaagactta tttttgtaat caattttaat agtagaatag aaaccactat
    11701 attagtcagt gtatgataca aattatttac ataaaatgta cttaaagaag tagcacaaac
    11761 gtataatata caaaacagtc ctgattttaa tttatttgtt actatatact ttttctcatt
    11821 agttaaagag ctaaaaactc ctaataataa taatgcttct aaaatatcaa gtattatttc
    11881 tctagtcatg tcatatcttc tcctcaataa agtattgact cttttgaagt attgtactta
    11941 tagtatttcc ccaaaagagc caatattttt atagcaaaaa ttcgtctgga caattaggct
    12001 gatgtgaatt aattaatgat gttggaacaa tagctagtgc tcctacaaat aatgctacac
    12061 atcctatcat tttcatagtt ttacgaataa gttttttcaa aagaaaccct cccttttaat
    12121 aaaattaata atctagatta tcagaataaa tcatttatta acaattaaat attctaaacc
    12181 ctttctaagt aaattaatct tttcattcat attattcact catttcataa aattttctat
    12241 ataataatat tattacattt taagactatt tacaacatat atttctaaat tatactatat
    12301 ttaaataaaa accattcagg aatattacct tttagagttt ttttctcctt gcaaatattt
    12361 agaaaatagc ctaagtgttt gttcataact catcattgtt ttttgtgata agtttttaga
    12421 ttgacaataa ttcatcaatt ttttccataa aaatagacct cccattattg tgtattgcac
    12481 caataaatta aaaagtctat tgcattataa aaataatatt tataggtttc aaaaataatt
    12541 tcaagctaat tccacaaggc ttttaatatg tttatcggtg tggaatatcc ccttaaccat
    12601 tggtataact aagactagct aaccctattt tgtaatctta acttatcagc aaccatcgct
    12661 ataaattctg aattagttgg tttgcctttt tcattattaa ttgtataacc aaaaagattg
    12721 gttatggttt ctacttgttc tctattccat gctacttcta ttgcatgtct tattgctctt
    12781 tctactctac tcgcagtagt attaaatttt tcgcctacca atggatataa ttcttttgta
    12841 accgatgata aaagatcaat atcattcact accatgttta ttgcttcgcg tacaaacata
    12901 taacctttta aattagctgg tattccaatc tcatgaataa tgcttgttat ttgaccaatc
    12961 atatccacat caactggctt acttctattg gttttaattt catcattacc agcataagaa
    13021 agtgttttcg gtgtttcatc attacatata ttttcattta gcgtttgtct tatcctatta
    13081 gcaaacactt ccatatcaaa aggttttata acataataat ctgctccaag tgatatagct
    13141 ctctgggtaa ttttttcatg accaactgct gataaaatta ttatacgagg ccttggctgg
    13201 atctccattg tatttagcct ctctaaaact cctagcccat caagaatcgg cataattata
    13261 tcgagtacta ctagatcagg ttttttttcc tcaatcaatt ttattgcttc tattccattt
    13321 tgtgcaatgc cggtaacgac tatatccttt tgcgttagta agtaatcatt aagaatatta
    13381 cagaattcct tgttatcatc aacaataatt atatttattt ttttctcttc catgttcgta
    13441 atctccttta catatcaatt atgcatccta ataattataa attctacaat taattggaaa
    13501 atccttttat tttaaaaaaa tattaaaaaa tattaccgaa ttaagtaata tagatagtga
    13561 ctctttctat ttcttatatt atttctacat ttataatata attagttata tattaacata
    13621 taactaatta tattgccaca cagcacattg tattttataa attcataata aaatctcaat
    13681 ttgatacatt atgtattcaa actgagattt ccatttcttt actatatata atttaaaagt
    13741 aaaaacaata atttttaaat tatactattt aagattatat gattttgcta gtttttcaaa
    13801 agctggtaat gaattttcta ttttcttgta atcaacgcaa tatgataacc ttgcatgccc
    13861 tgggcattca aaagcagatc ccgctactaa taatagctta aattcctttg catcctcgca
    13921 gaatttttta tcatccttta ttggtgttct aataaacaaa taaaatgctc cttgtggttt
    13981 tacgcaaaca aatcctattt ttgtaagata gttatataat aagtctctat ttttttgata
    14041 tatactaaca tcaacctcgg cctcaagaca atttgcaata actctctgga aaagtgatgg
    14101 cgcatttaca aatcctagaa ttctatttgc aacattaaga gatatcatta tatcatcaaa
    14161 acaatccatc tttgtatttg caactacata ccctattctt tccccaggca gtgataatga
    14221 tttactgtag gaatatccaa taaatgaatt tgtataatat ttcaaaatat atggaacaac
    14281 aacattatca taaactattt ctctataagg ctcatcagat ataagatata tgcttgtacc
    14341 taactcatcc tgtttttgat tcatcaaatt tgctaagtct tgtataacct tttcgcagta
    14401 tacgacaccc gttggattat ttggtgagtt aataataatc gcttttgttt tactatttat
    14461 tttatctttt aaactctcca tattaggttc aaaagtatca atatctgtag aaacgacaac
    14521 aagtttacca tcaaaattat ttacatagtt tctgtattca ccaaaaaatg gtgcaaaaac
    14581 aataacttca tcttctggat taagtaatgt tttcagtaaa atatttaatc ctccggctgc
    14641 cccacaagtc ataactatgt tattgtatga aatatctata ttatgctttt tatttaaaaa
    14701 ttcagcaatt tttcctctaa catcttcata tccagaatta ttcatatacc cgtggacaag
    14761 tttaggagct atttcattta atattttatt aatttcaact ttaatatttt caggtggggc
    14821 aacatttgga tttcctaagc tatagtcaaa aacattttct tcaccataaa tatcagataa
    14881 tcttttacct tcctcaaaca tagctcttat tatagaactg ttagcaacta aatctttcat
    14941 cttactcgat atcattttag gtctcctttt attatagaat aaaatatatt aataacccca
    15001 ttaattcatg tctaacttaa atagtttgaa ttattagttt atagtataac ataaatgtta
    15061 attatactca tattttttta tataattcct ctatatattt aatactcgaa tctaaatctg
    15121 ttggaactgt gtcctcaagt attatatcaa tgtatggctt tctttctttt attagagata
    15181 ataataatgg atagttaaat tgtccactgc caattgagac ttgttttact tttccatcat
    15241 cgtatataaa atctttagca tgaatgattg ctattttatc accaaataat tcgaatgact
    15301 tttttattat ctcatcctgt ttatcaaaat ttgtctcatc tataaaatta ataggatcaa
    15361 atataacttg taggttatta gaattaacac aatctattgc tctctttagc ctttctggtg
    15421 tattcatcac atgttttgtg actccctcaa ctccaactac aactccaaat ttttctgctt
    15481 cttttacaag tatttttatt gaacttagag acctcttaaa tgcctcttct gtattgttat
    15541 cttttgtata aacatactct ctattaagtg ctcctgtttc tgtcccaact atattacagc
    15601 ctaaatattt tgcaaaacgt atatgttctt tgaaattctc taatagttta ttaagttcat
    15661 tatcatctgg atttgctaaa tttatataac atccaagtaa acttatattt aagttatgtt
    15721 ttgtaagtat tcccttgata tgttcagcca ttcctggtgt catacttcca ctcgtaattt
    15781 taaattcagt tattatcttt ttaagtacaa attgtatact tttaatattt ttaccttcca
    15841 atattgctgc tagttcatcc aatttatatt gtcctatgtc atgcccgcga attccaattc
    15901 tcataaccca atccactccc taaataaatt ttattatctt taaatcatac ttgttatttc
    15961 cctaaaattt gtataccatt aatatataac atcaatatta taagaatgca ataattccat
    16021 ccattctgcc cttggctcct gatccgtaat tatataatct atatcctcat aatcaaagag
    16081 ttttacaaaa gatgttttat catatttatc atgatcgatt aacataataa cagtgttcgc
    16141 ttgctttatc ataatccttt taatttctgc ctcttcttcg ttagcatcta atactccttt
    16201 ttcaatatcc atacctttgc agcttacaag agctaaatct acactatact tttttatagt
    16261 acaatgcgtt ataggtcctt gcattgataa tgatcttcgt tttataactc caccggttaa
    16321 aataatattt agtgatgatt tattaagttc acttaaaacc cccactgaat ttgttataat
    16381 tgttacaccg cttctatctc taattaattt taaaacttca agtactgttg aactacaatc
    16441 agcaactatt gtactatctt ctttaataaa ttctattgct tttgaggcta catatttttt
    16501 attatctata ttagtctttg accttttata aaaaggtaca tcatcaattg ttctttcagc
    16561 atttaatatt gccccaccat aactcctagt gactatgcct tgcaccttta gtttttctaa
    16621 atctcgcctt attgtttctt ctgttacatt aaatttttga cttaactttg acacatataa
    16681 ctttttttct gttaaaacta tttgctttat aatttctaat ctctcaattg gtaacattcc
    16741 aattcctcct tgtatggatt tttgcttaat tttaatgaat gttataaaaa agagctaccc
    16801 ttttagaaat ttttctaatt taaggtagct ctttttatat cctaacatat taattattta
    16861 taaataaata ctagtttatt acatacttgc ttgtttctct ttagctttac attttttcca
    16921 attcttatat cctacaggat tatttcccca tagcttctca taatcccatc ctgttaattc
    16981 ttctacagtt ttacgagttt tctcatcaac gtcagccttt gatccacccg tctttaatct
    17041 ttttacttct ttcttaagta ttgcatgaga ttcccttgtt actgtaaatt taaatgatga
    17101 tataatacct ataataagaa atataatagg tgctactatt aatataacca ccataatatt
    17161 taaagcttct tgtggttgcg ttttaactcc agatacaaaa tgtgcctctt ctaatgcaac
    17221 tcccactaag aaaatagcaa gtgcctgaga agcttttcga aggaaacaca taaatcctgc
    17281 aaaaactccc tcacgtctat caccagatac tatttcgtct acatccggaa caaaagtata
    17341 gttattccaa ggtacaaaat ttattccacc acgtcctagt ccagcaatac atgataccgc
    17401 atataaagct ataatacttg ttggaatagt cttgtataca attaaatatc ctataatgct
    17461 tattataaaa attgaagata caactctaaa tgcagctcct ggatttaatt taagtgttag
    17521 gtatgttgct ataccaacac cagcaatttg gaatatatac attactgcaa ttaaatttga
    17581 tgccattata acattttgaa ataatgcaaa aactacaaaa taagtgaata ctgcattaaa
    17641 tgtgtcttgc gctaagtaac ccccaatata catacccaaa tgagctctga aagttctaat
    17701 tctaagtgtt gttaccaaat ctacatatat tttttgtaca ttttgcataa atgttaattt
    17761 ttctttaacc tcactcgcct ctgcagcctc tatctctgca agtggtcttt cccatgtaaa
    17821 tgtgtataca aggattaaaa caataacaaa tattacagta aaaatcatag ctgcatacaa
    17881 gaatgactta ggtgattctt ttcctaataa atttataagt cttcctggta taaatgctgc
    17941 taagaatgca gaaaactgag ctatgtacat ccttgcacta gtaagtttag cccttacttt
    18001 aaaatctgat gtcatttctg cagctagcgt atcgtatggt ataagtatca tagtatacac
    18061 taactcaaat gctatataag ttgcaagata gtaaaaataa gtgaatccac taatccaaat
    18121 agttgtgtaa actcctacga gaggtattgc aagtaacaaa aagaattttc gtcttccaaa
    18181 tctctttcct aatttagtct tatggaaatt gtctgttata aatcccattg taggacttgc
    18241 taccgcatcg acaacacgag ctaacgcaaa tattgaggca gcttgaattg gcgacaagcc
    18301 acaaaacgta gtataaaaat ataataacca tgcggatgtt aaagcaaatg cccccgctcc
    18361 tataaaatca ttcattccat atgaaaaata atttataaat cttatctttc catctttttg
    18421 actcatattt ttctccccct aattttactt ttatcatttg acaccgttta cttaaatcct
    18481 ttacattctt atatttatag attactttaa atacaacata aagtcaacac ttttaatatg
    18541 tattttattt gtatctattg gttttatatt tgtttaggac tgtattgttt tctaaagttt
    18601 atcattccct ctttataaaa tattataaat ggctctaccg tgcctaaata aacatattat
    18661 tgttattttt atatttttct ttgttttgtc ttgtttatgt gtatatttat tctctttagt
    18721 aatgtataat ttatatacag cgtaaaatta attataaaat ataatatagt ggggtgttat
    18781 tatgaaatta acagaaaaag aaatacgtat taaactggat ctagttgtta ataaactaat
    18841 taacctagat agtccatcag ttgaagaaaa gttacccaaa gaaggcggcg aagccatagg
    18901 attatttcct agagattttg gtattcaaga atgggattgg ccacaaggtg taggtctata
    18961 tggtttatta aaattagata aacacgacaa gagtgataag tatttagact ttttaactaa
    19021 ttggtataaa actaatatag aaataggatt accttctaaa aacatcaata ctacggcgcc
    19081 tctactaacc ttagtaaacc tatgtgatgt tattaataat cccgagtatg aaaacctttg
    19141 cttaacatgg gctgactggc tcataaattg ccttccaagg actaaagaag gtgcttttca
    19201 acatgtaact agtgcaaatg gtgataggca agcagtaagg ttaaatgaaa gtgagatgtg
    19261 gatagatacc atatttatga ccctcttatt tttaaataaa atgggtcaaa aatataatag
    19321 gaaggattgg gttaatgaat caattaatca aatgcttgtt catataaaat atttatatga
    19381 taaaaaatct ggtctcttct atcacggttg gagttttaat gaaaacagta attttggtga
    19441 agttttttgg tgcagaggta attcgtggtt tacttttgga attttagact atatcgaggc
    19501 atttgaaggc acaatgaatc caggtatcaa gaaattttta cttgatactt ttaaatctca
    19561 agtaaatacc ttagttaaat atcaagcaga gtccggttta tggcatacag ttatagacga
    19621 tgttactagt tatgaggaag tttctggctc tgcggctata gtcactggta ttttaactgg
    19681 aattagactt ggaatacttg atgactcatt caaaccatat gctgagaaaa caataaaggc
    19741 attatgtaat aacatagaaa aagatggtac tgtattaaaa gtatccggtg gaactggcat
    19801 gggatataat gtagatcatt ataagaatat aattatagct ccaatggctt atggacaatc
    19861 attaactata atggctcttg tggaagcact taaccatcta taaatcataa ttaaatagag
    19921 tgttattgat agctaatagg tagtttaaaa taactaccta ttagctattc ttttgtttga
    19981 tactattttc atatttaaat ataattataa aacgcttcat atattcattc attgcttcta
    20041 aaaggtcaaa ttctccatca taaagacacc aattatatac aacccctctc gctgctataa
    20101 ataaatattc agtaatactt tctttagaca tctcattact aagctcattt ttttcttgcc
    20161 ctctttctat aataatattc agtagatttt gcatatccct acctttagtt ataaataact
    20221 tattatttga gttatacaat aatttcattg tgtcaattcc aacttggaca ttatactttg
    20281 cataataatc aaaatactta ataatttcat ttgtagcgtt atcgcaatat atattattgg
    20341 caacttccgt aataaaatat tcatctgctc gcttatatat ttctataaga atttcatttt
    20401 tagatttaaa acaattataa aaagaaccta cagaaactcc ggctttttta catatatctt
    20461 gtattttaat atttttataa cctttcttgt ccataaggtc aattgcactt ttatatattt
    20521 tatttttagt gttaagtgct tgtaattgtc tattgtttaa cttttgttca tccataataa
    20581 atctcctaac tataatcttt ttctaagtaa attatagttt attaatatgc tttgtcaata
    20641 taattataag gttttagttt tataattgta ttgacataaa tataacatat ttatataatg
    20701 aatctattca gtgaatttat ttcatagggg gtattatttt gaaaaaaaag catgaaattc
    20761 tttttcagcc aatgaaaata ggtaaattag aaattaaaaa cagatttgtt atggcaccaa
    20821 tgggtcctgg tgggttatgt gacgccgatg gaacttataa tgaacgtgga gtagagtatt
    20881 acgttgagag ggctaaaggc ggtaccggat taattattac cggagtaact atggttgaaa
    20941 atgacattga aaagtgtgct ttaccatcaa tgccttgtcc aacacttaat cctttgaact
    21001 ttgttaaaac aggaaaaatt atgactgaaa gagtacatgc ttatggggca aaaatgtttc
    21061 tgcagttgtc agctggattt ggaagagtaa gtataccttc aattgtaggc aaaaccgcag
    21121 tagcaccgtc accgattcct catagatggc ttgatggagt tacctgtaga gcattaacta
    21181 tagaagaaat aaaaacttat attacaaaat ttgcgcagtc agctgttata gctaaaaaag
    21241 ctggtttcga cggtattgaa attcatgccg tacatgaagg ttatttactt gatcaatttg
    21301 caatttcatt ttttaataat agaacagatg agtatggtgg aagtttaaga aatagactaa
    21361 gatttgctat agaagttgta caagcgataa aagaagcatg tggacaggat tatccagttt
    21421 cactacgtta tagcattaaa agttttatta aagattggag acaaggtggc cttcctggtg
    21481 aagatttcga ggaaaaaggt agagatatag aagagggaat tgaggcagct aaaattcttg
    21541 aagaagctgg ttatgatgct tttaatggag atgtaggttc ttatgattct tggtattgga
    21601 gtcatccacc gatgtatcag aaaaaaggta tgtatttaga gtacaatgaa atactaaaaa
    21661 aagcacttaa agttccagta attactgctg gtagaatgga agaccctgaa cttgcaagtg
    21721 aatctatcct acaaggaaaa acagacatga ttgcgcttgg aagacctctc cttgcagatg
    21781 ctgaaatacc taataagata atggctgata aatttgataa ggtaagacct tgcttatcct
    21841 gccaagaagg ttgcatggga aggctcgcta cttatgccac agtatcttgc gctgtaaacc
    21901 cagcttgcgg aagagaaaat gaatatggca tagcttctgc tagaaaaatc aaaaaagtgg
    21961 tcatcattgg tggcggagta gctggatgtg aagcagctag agtctgtaca ctaaggggtc
    22021 ataaagttac tttgcttgaa aaaagtgata aactaggtgg aaatattata gctggaggag
    22081 ttccagattt taaggacgac
//
