LOCUS       NZ_CP086140            21564 bp    DNA     circular CON 20-JAN-2024
DEFINITION  Clostridium estertheticum strain CF016 chromosome, complete genome.
ACCESSION   NZ_CP086140
VERSION     NZ_CP086140.1
KEYWORDS    RefSeq.
SOURCE      Clostridium estertheticum
  ORGANISM  Clostridium estertheticum
            Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 5053333)
  AUTHORS   Wambui,J., Stevens,M.J.A. and Stephan,R.
  TITLE     Clostridia strains as spoilage organisms
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5053333)
  AUTHORS   Wambui,J., Stephan,R. and Stevens,M.J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2021) Institute for Food Safety and Hygiene,
            University of Zurich, Winterthurerstrasse 272, Zurich, Zurich 8057,
            Switzerland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2021
            Assembly Method                   :: unicycler v. 1
            Assembly Name                     :: CF016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Nanopore/Illumina miniseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/20/2024 05:10:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,249
            CDSs (total)                      :: 5,114
            Genes (coding)                    :: 5,019
            CDSs (with protein)               :: 5,019
            Genes (RNA)                       :: 135
            rRNAs                             :: 15, 14, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 14, 13 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 22 of 95
            Pseudo Genes (incomplete)         :: 78 of 95
            Pseudo Genes (internal stop)      :: 14 of 95
            Pseudo Genes (multiple problems)  :: 16 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:27:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2348254
            Orig. end                         :: 2369818
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086140.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21564
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="3"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21564
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21564
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11564](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11564
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            591..824
                     /locus_tag="LL065_RS11220"
                     /old_locus_tag="LL065_11205"
     CDS             591..824
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS11220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_11205"
                     /product="hypothetical protein"
                     /protein_id="WP_071612995.1"
                     /transl_table=11
                     /translation="MTNDEMYKRIIAMTSIKTAKSFIKTYDISKSDLSKLCKKFNIFID
                     GKATKDDMIDRFLGETLGKKLKNKVINKYNIR"
     gene            908..1918
                     /gene="splB"
                     /locus_tag="LL065_RS11225"
                     /old_locus_tag="LL065_11210"
     CDS             908..1918
                     /EC_number="4.1.99.14"
                     /GO_function="GO:0016830 - carbon-carbon lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0006290 - pyrimidine dimer repair [Evidence
                     IEA]"
                     /GO_process="GO:0046500 - S-adenosylmethionine metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="splB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158608.1"
                     /locus_tag="LL065_RS11225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11210"
                     /product="spore photoproduct lyase"
                     /protein_id="WP_226137015.1"
                     /transl_table=11
                     /translation="MKLFIPDIAYIDPKLLKFEESKKTIKYLEELKVPIVNSKKVVIDS
                     GSPEKNYAAAKKTVLFTTNGQKKLVSCKPSADYQFSLSSSCPANCEYCYLQTTQGEKPF
                     MKIFLNIEEILENIQTYIDANLPSITSFECASITDPIALEHLSGNLKKCIEFFGRSEKG
                     RLRLVTKFDDVDLFLKLKHNKHTKFRFTLNTPYVIDNFEHNTSTFKERIGAVKKIASAG
                     YPIGFIIAPIMIYDNWRSEYKELFETLKIALADYKEEVSFELIQHRFTKAAKELIVQRF
                     KNTKLDLDEEKRLLKWGPYGKFKYVYKKPESEDIKNYISEQININFDLAIIEYFT"
     gene            complement(2001..2669)
                     /gene="aat"
                     /locus_tag="LL065_RS11230"
                     /old_locus_tag="LL065_11215"
     CDS             complement(2001..2669)
                     /EC_number="2.3.2.6"
                     /GO_function="GO:0008914 - leucyl-tRNA--protein transferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="aat"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010233109.1"
                     /locus_tag="LL065_RS11230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11215"
                     /product="leucyl/phenylalanyl-tRNA--protein transferase"
                     /protein_id="WP_226137016.1"
                     /transl_table=11
                     /translation="MTVYRLSNELIFPHPSLSDDDGLLAIDGDLSQERLLLAYSNGIFP
                     WYSDDEPILWWSPDPRFIVYPKDIRTSHSMKKTLKKNIYKVTFDTHFRDVISNCSNLRR
                     EAGTWITNEMIEAYCKLHALGYAHSVETWFNDELVGGLYGISIGKCFFGESMFSTMDNA
                     SKVAFITFGRVLENKGFSLIDCQVHTNHLESLGAVYMPREKFLELVKDGISKLPLKLSL
                     "
     gene            2879..3874
                     /locus_tag="LL065_RS11235"
                     /old_locus_tag="LL065_11220"
     CDS             2879..3874
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017416249.1"
                     /locus_tag="LL065_RS11235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11220"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_226137017.1"
                     /transl_table=11
                     /translation="MKLSYKERINNVKPVVVVSRCLGFEACRYNGQMDSCNLVDKLNDY
                     VEFITVCPEIQIGLDTPRDAIRIVKEDELSPVKLVQHVTERELSTEMFEFGEEFLKDLP
                     KVDGFLLKSKSPSCGIKEVKIYKSAQKGSSSVKGKGLFGELVINKFPSAAIEDDGRVKN
                     YNIRQHFLTKLYIMKNFRVIEESMLIEDLVEFHSTNKLLLMSYNQKQLKILGRIIGSHG
                     ELSAKQVYEEYAINLNLALNKLPRYTSNINVLIKSMGYFSDKLTHREKEFILNTIEQYR
                     ESKIPFSVPLYVIKSNAIRFEEKNLINQTFFEPYPLQLDNVTDSGKGLDK"
     gene            3970..4737
                     /locus_tag="LL065_RS11240"
                     /old_locus_tag="LL065_11225"
     CDS             3970..4737
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS11240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_11225"
                     /product="hypothetical protein"
                     /protein_id="WP_226137018.1"
                     /transl_table=11
                     /translation="MKNKKILYSLLTIILIAFVCANYSLIHYMNKNDLKLEACGNLPYL
                     KFTSKAIGNGNSLQTSVTTNLARVSTDTKFIFKIKYKDNVVRNIVLEKYFNSSKVLIRK
                     DKEELNEYFKNQGYTVFNMSTDEVVFVNNSNRYSYKANRYFLGVYSDMVTIYKTDENGN
                     IAASKLFNANVYSADGKQQKYDFEAIDKGELQHIKIIDLKEKDGLVEDLIRGRKYSKDD
                     DTKKDMKDSEEYEKGEFKSPAKAFDYAMGLLKS"
     gene            5147..5746
                     /gene="ruvA"
                     /locus_tag="LL065_RS11245"
                     /old_locus_tag="LL065_11230"
     CDS             5147..5746
                     /EC_number="3.6.4.12"
                     /GO_component="GO:0009379 - Holliday junction helicase
                     complex [Evidence IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010965583.1"
                     /locus_tag="LL065_RS11245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11230"
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="WP_226137019.1"
                     /transl_table=11
                     /translation="MFEYIKGIFVGFNKDYIILDNNGMGYRIYTSGSTMAKMPKTNETV
                     LLYIKQIVREDFIGLYGFLTKDEIEMFSLVISINGVGSKAGLSLLSICSVTNLKYAIVS
                     GDEKTLIRAPGIGKKIAQRIILELREKIHLEQSTTQDLSRNLGMNLIEDRKLREVLGAL
                     ISLGYSEKESEKAMSAVSHEQSLENIIKDCLKYLMN"
     gene            5761..6768
                     /gene="ruvB"
                     /locus_tag="LL065_RS11250"
                     /old_locus_tag="LL065_11235"
     CDS             5761..6768
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010965582.1"
                     /locus_tag="LL065_RS11250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11235"
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="WP_226137020.1"
                     /transl_table=11
                     /translation="MDDTEERIITSSITEEDVDAEYSLRPQKLGEYIGQSKIKEKLSIF
                     IKAAQNRDEALDHVLLYGPPGLGKTTLANIIAKEMKGNLKVTSGPAIERAGDLAAILTS
                     LSDYDVLFIDEIHRLNRSVEEILYPAMEDYALDIVIGKGASAKSIRLDLPRFTLIGATT
                     RIGLLTAPLRDRFGVLSAMEYYSGGELKEIVIRSAAILKVDITSDAAVEIARRSRGTPR
                     IANRLLKRVRDYCDVKGNGIIDLNIAKSASELLEIDDEGFDRIDNKMLEAIIDNFNGGP
                     VGIETLSYFVGEEIGTLEDVYEPYLIQKGFIIRTPRGRVASKKAYQHLNRQQKT"
     gene            6856..7881
                     /gene="queA"
                     /locus_tag="LL065_RS11255"
                     /old_locus_tag="LL065_11240"
     CDS             6856..7881
                     /EC_number="2.4.99.17"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="queA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017414653.1"
                     /locus_tag="LL065_RS11255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11240"
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="WP_226137021.1"
                     /transl_table=11
                     /translation="MKVKDFYFDLPKELIAQHPLEKRDESRLMVINKTKKEIDHKHFKN
                     IIDYLNPGDCLVLNDTRVLPARLLGVKEGTGGKMEFLLLKRIDINKWETLVKPGKKAKI
                     GATFIFGNGELKATVISDSEGGSRIVEFEYDGIFEEILDKLGEMPLPPYITEKLEDKER
                     YQTVYSREEGSAAAPTAGLHFTKQLLAQIKAKGVKIAFVTLHVGLGTFRPVKAEEVEEH
                     EMHSEHYMLNSETAQLINETKENGGRVIAVGTTSNRTLESIANDNGRVCAKSGWTDIFI
                     YPGYKFKIVDALITNFHLPESTLIMLVSAFADKDLIMGAYEVAVKEKYRFFSFGDAMFL
                     Y"
     gene            7939..9069
                     /gene="tgt"
                     /locus_tag="LL065_RS11260"
                     /old_locus_tag="LL065_11245"
     CDS             7939..9069
                     /EC_number="2.4.2.29"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008479 - tRNA-guanosine(34) queuine
                     transglycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tgt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) bTGT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003490661.1"
                     /locus_tag="LL065_RS11260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11245"
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="WP_216203040.1"
                     /sec_met_domain="bTGT (E-value: 3.9e-158, bitscore: 524.2,
                     seeds: 1816, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKLLKKSGKVRRGEFTTPHGTIQTPVFMNVGTLAVIKGAVSTMD
                     LKEINCQVELSNTYHLHLRPTDTVVRKMGGLHKFMNWDRPILTDSGGFQVFSLSKMRKI
                     KEEGVYFNSHIDGKKIFMGPEESMQIQSNLASTIAMAFDECIPNPSTKEYVVDSVARTT
                     RWLERCKIEMDRLNSLSDTINNKQMLFGINQGGTYEDIRIEHAKTISKMDLDGYAIGGL
                     AVGESHEEMYRIIDAVVPHLPQDKPIYLMGVGYPSNILEAVSRGVDFFDCVLPARNGRH
                     GNVFTKDGRINMFNAKFELDAGPIDEGCKCPTCKHYTRAYIRHLFKAKEMLAMRLCVLH
                     NLYFYNKLMEDIRDAIDNDCFEEFKAEKLAQWNEGK"
     gene            9169..9459
                     /gene="yajC"
                     /locus_tag="LL065_RS11265"
                     /old_locus_tag="LL065_11250"
     CDS             9169..9459
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="yajC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010233518.1"
                     /locus_tag="LL065_RS11265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11250"
                     /product="preprotein translocase subunit YajC"
                     /protein_id="WP_226137022.1"
                     /transl_table=11
                     /translation="MGQLGSVFTMVLMLAVFYLVIFIPENKRKKKYAALLSNLKVNDEV
                     LTKGGVMGKIINIQDEYIILESGPDRTRIKLAKSGIGTVINLNTNEVVEKK"
     gene            9563..9931
                     /locus_tag="LL065_RS11270"
                     /old_locus_tag="LL065_11255"
     CDS             9563..9931
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017414650.1"
                     /locus_tag="LL065_RS11270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11255"
                     /product="TIGR04086 family membrane protein"
                     /protein_id="WP_071612986.1"
                     /transl_table=11
                     /translation="MENKKKYSYAGEGVFRASILTLIILVIYSIVTTVLPASMKVTSVF
                     YIVITLVSVLYGSIFAAKKAGEKGWLMGIMVAATYMLILYLVKVFGGGSAAIGMREIVR
                     TSLALGIGTLSGMLGINL"
     gene            10001..10138
                     /gene="scfA"
                     /locus_tag="LL065_RS11275"
                     /old_locus_tag="LL065_11260"
     CDS             10001..10138
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003357718.1"
                     /locus_tag="LL065_RS11275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11260"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_071612985.1"
                     /sec_met_domain="TIGR03973 (E-value: 2.6e-23, bitscore:
                     79.7, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.3e-22, bitscore: 77.5,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHIKTINAATIKESLKKPGCKECANSCQSACKTSCTVANLACEN
                     "
     misc_feature    complement(10157..10170)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 17.97"
                     /tool="antismash"
     gene            10200..11564
                     /gene="scfB"
                     /locus_tag="LL065_RS11280"
                     /old_locus_tag="LL065_11265"
     CDS             10200..11564
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013725271.1"
                     /locus_tag="LL065_RS11280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11265"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_226137023.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.9e-26,
                     bitscore: 89.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2e-87, bitscore:
                     291.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 7.6e-13, bitscore: 47.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-13, bitscore: 47.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.1e-20, bitscore:
                     70.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.7e-06, bitscore: 26.5,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHKFIQDNEHYVIDVNSGALHMVDEIVYDLLDENELRKKEDL
                     IEDFKNKYSIEDISEVYDEIQSLIQEETLYTGDLYKSIALSGAKEEPYIKALCLNIIHA
                     CNLRCKYCFADEGEYHGARKAMSVEVGKKSIDFVLEKSGPRKNIEIDLFGGEPLMAFEM
                     IKEIVEYARVQEKIYKKSIRFTMTTNATLFNDEIMKYMDENMGNIVLSIDGRKAVNDKV
                     RVKADGSGSYDNILPKIKKMVDMRDKSKQYYVRGTFTRDNTDFFEDIKHMADLGFEEIS
                     IEPVVLPPEHNLSLREEDLPVIFEQYDKLYTDMLKRYKDGTSFKFYHFNIDLKGGPCVY
                     KRIAGCGAGHEYVAITPDGDIYPCHQFVGNKDFLIGDIYTGITNKKMVKEFKEAHIYNK
                     PACTECWAKFYCSGGCQANNFNFNGDMHIPYEIGCKMQKKRIECAIALKAQTMNK"
     aSDomain        10203..10499
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LL065_RS11280_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="2.40E-28"
                     /identifier="RREFam024.1"
                     /label="LL065_RS11280"
                     /locus_tag="LL065_RS11280"
                     /protein_end="100"
                     /protein_start="1"
                     /score="89.3"
                     /tool="antismash"
                     /translation="SLIHKFIQDNEHYVIDVNSGALHMVDEIVYDLLDENELRKKEDLI
                     EDFKNKYSIEDISEVYDEIQSLIQEETLYTGDLYKSIALSGAKEEPYIKALCLN"
     gene            11644..12882
                     /gene="secD"
                     /locus_tag="LL065_RS11285"
                     /old_locus_tag="LL065_11270"
     CDS             11644..12882
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017414647.1"
                     /locus_tag="LL065_RS11285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11270"
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_226137024.1"
                     /transl_table=11
                     /translation="MKKKKSTILFLISVCVVGLLAFTGFHGFTIGDYRVKPFTQSINKG
                     LDIQGGISVLEEVKGGAVDAKTLDRAIELISMRVNKMGISETLVAKEGLNRIRIEIPGK
                     FDSKEILDTVAKSGELKFVGPDKATILTGKDVKDATAAYGQDNKPVINLVLNDSGKTKF
                     AAATQKFLGQVITVYMDADVLTAPKVQVAILDGKAEINGFATLAEATTKSQIIKSGALP
                     VSLKAVSVKTVGATLGEAAMAQSMKAGVVAILFVFLFMLLYYRAPGVIANISLLLYVVL
                     VLGAFSAMNATLTLSGIAGFLLTIGMAVDANVLIFERIREELKTGKSIKSSVHAGFHRA
                     LPSILDSNITTIVAGLVLYMMGTGSVKGFALTLVVGVIISIFTALTCTKFLLKLAVEMG
                     LISKTSHFGVKRG"
     gene            12887..13753
                     /gene="secF"
                     /locus_tag="LL065_RS11290"
                     /old_locus_tag="LL065_11275"
     CDS             12887..13753
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011100351.1"
                     /locus_tag="LL065_RS11290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11275"
                     /product="protein translocase subunit SecF"
                     /protein_id="WP_226137025.1"
                     /transl_table=11
                     /translation="MLKIVEKTKLWFSISLIIIIIGMGVIATKGLNLGIDFKGGTAITI
                     NMNQKFDKSDVDKIIDKHAKGEYLSKTINDAKEIEITVKSDALSADETATMLKEIKTQF
                     KSSTLVSEDTIGASIGSELKTKAVSALIVAMLFMLVYVGFRFEFKFAASAILALVHDIL
                     ITITVYAVFQTPVNATFIAAILTVVGYSINDTIVIFDRIRENQRIMRKATIEEITNTSV
                     TQTMARSINTVVTVLICIFSVWVLVPAIRDLSGPLLIGIGVGCYSSIFIASPMWAFLKK
                     RTKKVTA"
     gene            13892..14764
                     /locus_tag="LL065_RS11295"
                     /old_locus_tag="LL065_11280"
     CDS             13892..14764
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017752802.1"
                     /locus_tag="LL065_RS11295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11280"
                     /product="DHH family phosphoesterase"
                     /protein_id="WP_226137026.1"
                     /transl_table=11
                     /translation="MVDFFKDIQKNNNDFIEYNMYNPFLLKGMEDALKRIIKAINHREK
                     IVLYGFYDVDSITAISLLMLVLKFVNADVEYFIPGELSENRDLVEKDITGHIKYLGPGL
                     IITLGCGTNSFSEVELCKGIGIDVIITDFHKPIKHVPHTIVVNPKQKGCKYPFKELCTC
                     GMTFKLAQAISTYYKMKSVNKYMDLVMIGTIYSRKKIESENKIIVEEGIKQLNCTTNYG
                     ICALIKIHNINIINEATVLKLASTVKPTINPVGKMDNAKIVVELFITTEKNRALQISKY
                     LDKELKNSI"
     gene            14842..15360
                     /locus_tag="LL065_RS11300"
                     /old_locus_tag="LL065_11285"
     CDS             14842..15360
                     /EC_number="2.4.2.7"
                     /GO_function="GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006168 - adenine salvage [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008420969.1"
                     /locus_tag="LL065_RS11300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11285"
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="WP_226137027.1"
                     /transl_table=11
                     /translation="MELKNSIRVIENFPKEGISFKDITTILQDGKVLKQTIDDIVEYLR
                     DKQIDVIVGPEARGFLFGVPVAYALGAGFVPVRKPGKLPYETLQIEYELEYGTDKLEIH
                     KDAIKPGQRVVIVDDLLATGGTVAAVTKLIEEMGGDVISLNFVIELTGLHGKEKLKDYD
                     IMSLVKYNS"
     gene            15477..17660
                     /locus_tag="LL065_RS11305"
                     /old_locus_tag="LL065_11290"
     CDS             15477..17660
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003376117.1"
                     /locus_tag="LL065_RS11305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11290"
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_226137028.1"
                     /transl_table=11
                     /translation="MLEKLLSKIENNCNNVDKDLIIKAFNFSYAAHKEQKRESGEPYIV
                     HPVEVACILAEMGLDTSTIVAGLLHDVIEDTVYTFEDVSREFNIEVANLVEGVTKLGLI
                     KYKTKEEEQADNVRKMLLAMAKDIRVILIKLADRLHNMRTLKYMPIAKQKQKAKETLDI
                     YAPLAHRLGMSKIKWELEDLSLRYLNPNEYYNLVRKIAEKRVEREDNINNIMEELKYNL
                     NIVGIEAELDGRPKHFYSIYRKMVTQNKTIDQVFDLTAVRILVNDIGNCYAALGIVHTV
                     YKPIPGRFKDYIAMPKPNMYQSLHSTVIGPHGKPFEIQIRTYEMHKTAEYGIAAHWKYK
                     EGTDQSDDKNLDSKLSWLKDILEWQGETFDAEEFMEGFKIDLFSDEVFVFTPKGEVINL
                     PLDATPIDFAYRIHTDIGNKCMGAKVNGRMVPLEYHLKTGEIVEVITSPTAKGPNIDWL
                     NITKSNQAKSKIKAWFKKSKREESIEKGKELLERESKRQEYNFGVIAKGEAIEKIYKKY
                     NFRSLDDLFAYVGVGDIMPSTVVNRLKEVYENKNKQENMTVEDIEEKITKTIGKDDKKK
                     LDYSGLIVKGEGNLLVRFAKCCNPVPGDEIIGYITMGRGVSVHRRDCKNAKSLMTNDAN
                     KVVEVSWGASEGKGYITEIQIKADDKYGLLSSIMEIITLTKTQLYSINAKTLKNNVALI
                     NIKLKVAGIDNLKELQKKIAKLSGVLEVYRIKN"
     gene            17693..18139
                     /gene="dtd"
                     /locus_tag="LL065_RS11310"
                     /old_locus_tag="LL065_11295"
     CDS             17693..18139
                     /EC_number="3.1.1.96"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dtd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012344539.1"
                     /locus_tag="LL065_RS11310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11295"
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="WP_226137029.1"
                     /transl_table=11
                     /translation="MRAVVQRVKSSRVEVSGKVVSEIGLGLNVLVGICDGDTIDDIKYL
                     KDKILNLRIFDEDNKMNKSLIDVGGELLIVSQFTLYGDCRKGRRPSFMRALGGQQSEKL
                     YLEFVKQCSEVIGEVKTGEFGADMQVYIQNDGPVTLLLESKKDF"
     gene            18150..18758
                     /locus_tag="LL065_RS11315"
                     /old_locus_tag="LL065_11300"
     CDS             18150..18758
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010292949.1"
                     /locus_tag="LL065_RS11315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11300"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_226137030.1"
                     /transl_table=11
                     /translation="MEIKKVIAGIYGANCYIVMDKNTSEAVVIDPGGDVDDIVKVINNM
                     GAKVKYILLTHGHVDHTSGVCELKAITNAIVCISKKDDDLITKGEYLFGPLIKGGADKL
                     LSDGDIIKIENIQINCVDTPGHTPGGMSFLTGKYSFTGDTLFAGSIGRTDFVGGDFNAI
                     INSIKSKLLCLPGDTLVYPGHGPGSTINKEKLNNPFLQD"
     gene            18812..20239
                     /locus_tag="LL065_RS11320"
                     /old_locus_tag="LL065_11305"
     CDS             18812..20239
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010233508.1"
                     /locus_tag="LL065_RS11320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_11305"
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="WP_226137031.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-22, bitscore: 79.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKVKLSNEQFNYDVFQIINLFYFFPDIKFVEEDYDFNINVGETV
                     IDIQGEPESFKYFVNNAYKLKDEVKKAVFIYFSKNTTQELPWGTIIGIRPSKKALDLLE
                     RGVTDDKIIAEFKEKHVTREDKAQLCIDVAKFERNIVNKEKNNVSIYIDMPFCPTRCIY
                     CSFTSNPIGKCKNVVMPYLEALAHEIKSVGEYIREKKLNIECVYFGGGTPTAINNEQFE
                     FIMNYIYDAFILQNNVREFTVECGRPDSITREKLITMKKYGVHRISINPQTMNDDTLEL
                     IGRNHCVEDVFEKFEMARELGFNNINMDLIVGLPGEKISHMIKTCNEIYKIKPDSITIH
                     GMSIKRASRLHENMLNNYRFEVPGQEELNKMYGLTVELTKKLDMKPYYMYKQKNMIGNM
                     ENIGYTTLSKEGIYNIQMIEEKQTVIALGADAVSKVVFLDENRHERFANVKDVREYIKR
                     VDEMIDKKIVLLNTLYT"
     misc_feature    complement(20256..20271)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
ORIGIN
        1 gaagttttat ataaagcaaa agatattttc aataggtgac aattttagta ttaaggattt
       61 ttcaggcaat gatatgttta aggtagaagg aaaaattttt tcaataggaa ataagcttag
      121 aatttatgac atgaaggata atgaaattgt atatattgag cagaaattat ttaagttatt
      181 accggaatat aatatatatc taaatggaaa ctatgccgcc aaggtaaaga aagaatttac
      241 tttttttagc aataggtttc atatagaaag taatatgggc gattatgaga ttgaagggga
      301 ttttttagct catgattttt caatagtgaa aaatggtaaa agtattgctc aaataaacaa
      361 gaggtgggtt tcatggggag acacctatga aatagatata aatgaatcag aaaatcatgt
      421 atttgtatta gcaatggtaa ttgtaattga ccaagtgctg tatgacaata aaaatcaaaa
      481 taatggataa atgtgagaag taatagattt tattataatt gatgtattga tgagggttaa
      541 gatgatataa tgttaatgta tttgataaat aaaagattag aggtgttatc atgactaatg
      601 atgaaatgta taaacgaata attgctatga ctagtattaa aactgcaaaa agttttatta
      661 aaacttatga tataagtaaa agcgatttaa gcaaactttg taaaaaattc aatatattta
      721 tagacggtaa agctactaag gatgatatga tcgatagatt tttaggcgag acattgggta
      781 aaaaactaaa aaacaaggtg attaacaagt acaatattag ataagttttt aaaacatgcg
      841 attttatgaa taggataagt gtataaataa ctttatttaa taaaacaata cctatgaggt
      901 gaagttaatg aagttattta taccagatat tgcctatata gacccgaaat tattaaaatt
      961 tgaggagtca aaaaaaacaa taaaatatct agaagaatta aaggtgccta tagttaattc
     1021 gaaaaaagtt gtaatagact ctgggtctcc cgagaaaaac tatgcagctg ctaaaaagac
     1081 tgttcttttt acaacaaatg gtcaaaagaa attagtgagt tgtaaaccat ccgcagatta
     1141 ccaattttcg ctttcgagtt catgtcctgc aaattgcgaa tattgttatc tgcaaactac
     1201 tcaaggtgag aagcctttca tgaaaatatt cttaaatatt gaagaaattt tagaaaatat
     1261 acagacgtat atagatgcta acttgccaag tattacttct tttgaatgtg ccagtataac
     1321 tgatccaatt gcacttgagc atctaagtgg aaacttaaaa aaatgcatag agttttttgg
     1381 gcggagtgag aagggaagac ttagacttgt aaccaagttt gatgatgttg atctattttt
     1441 aaaactaaaa cataacaaac acacaaaatt tagatttact ttaaacacgc cttatgtaat
     1501 agataatttc gaacataaca cttcaacttt taaagaacga ataggcgcag tcaaaaaaat
     1561 agcttctgct gggtacccaa taggatttat aattgcacct attatgatat atgataattg
     1621 gaggtcagag tataaggaac tatttgaaac gttaaaaata gctcttgcag attacaaaga
     1681 ggaagtaagt tttgaactta ttcaacatag atttacaaag gctgcaaagg aacttatagt
     1741 gcagagattt aaaaatacta agcttgatct ggatgaagaa aaaaggttat taaaatgggg
     1801 accatatgga aaattcaagt atgtatataa gaaaccagag agcgaggata taaagaatta
     1861 tatctcagaa cagataaaca ttaattttga tctggcaata attgaatatt tcacttaata
     1921 attaaaatat tttagggatt taaataatca tcatgaaggt ttaggtcttc atgatgattt
     1981 attttttaat attatgtagc ttataatgat aattttaaag gcaattttga tattccatct
     2041 ttcacaagtt ctaaaaactt ttctctaggc atataaacgg cgcctaaact ttcgagatga
     2101 tttgtatgaa cctgacaatc aattaaagaa aatcccttgt tttctagtac tctcccaaat
     2161 gtaataaagg caactttaga tgcattatcc atagtagaaa acattgattc accaaaaaaa
     2221 catttgccta tgcttatgcc atatagtcca ccaactaatt catcattgaa ccaagtttct
     2281 acgctgtggg catagccaag tgcgtggagt ttgcagtaag cttcaatcat ttcatttgta
     2341 atccatgtgc cagcctcacg cctgagattt gaacaattag atataacatc tctaaagtga
     2401 gtatcaaagg taactttata tatattcttt ttaagtgttt ttttcataga gtgggaggtt
     2461 cttatatcct ttggatatac aataaatctt ggatctggtg accaccaaag tattggttca
     2521 tcatctgagt accaagggaa tattccatta gaatatgcaa gtaataatct ctcttgcgat
     2581 aaatctccat caatggcgag taacccatca tcatctgaaa gagaggggtg agggaatatt
     2641 aattcatttg ataatctata aactgtcata ataactcctt tcaggatata acctataaac
     2701 ttattatata ctacctaaat caatcttaca tgcttttacg ttgatagaca taaaaatttg
     2761 attaaaaaga aagttatgga gcattataaa aaagaggaaa actaaaataa atattgaagt
     2821 aacataaata tataatcaaa tgaaaaagta tagcgaatta ttgagaggat gtttttatat
     2881 gaagttgtct tataaggaaa gaataaataa tgtaaaacca gtagttgttg tgagtaggtg
     2941 cttagggttt gaagcgtgca gatataatgg tcagatggac agctgcaatt tagtagataa
     3001 attaaatgat tatgtggagt ttataacagt ttgccctgag atacaaatag gacttgatac
     3061 cccgagagat gctataagga ttgttaaaga agatgaacta tcacctgtaa aattagtgca
     3121 acatgttact gagagagaat taagcacgga aatgtttgaa tttggagagg agtttctaaa
     3181 agaccttccg aaagtagatg gctttttact gaaaagtaaa tctccatctt gtgggataaa
     3241 ggaggttaaa atttataaaa gcgcacaaaa gggttcatca tcggttaaag gaaaaggatt
     3301 atttggtgaa ctagtaataa ataaatttcc tagtgccgcc atcgaggatg atggaagggt
     3361 taaaaactat aatataaggc agcatttttt aacaaaatta tatattatga agaattttag
     3421 agttattgaa gaaagtatgc ttatagaaga tttagttgag tttcatagca caaacaagct
     3481 tcttcttatg tcgtacaacc aaaagcaatt gaaaatactc gggagaatta taggtagcca
     3541 tggggaatta agcgcaaagc aagtttatga agaatatgca ataaacctta atcttgccct
     3601 taataagtta ccaagatata catctaatat aaatgtgctt ataaaatcta tgggatattt
     3661 ctcagataag ttaacacata gagaaaaaga atttatatta aatacaatag aacaatatag
     3721 agaaagtaaa atacctttta gtgttccact ttatgttata aaatcaaatg ctatacgttt
     3781 tgaagagaag aatcttatta atcaaacttt ctttgaacct tatccacttc aattagataa
     3841 tgttactgat tctggaaaag gtctagataa ataaaacaaa ttaaattata tgtataattg
     3901 tgatatattt ttaatttatt gaatgaataa tcctttgttt ggacataatt ccaaataagg
     3961 aggggaaaaa tgaaaaataa aaaaatttta tattcacttt taacaataat cttaatagct
     4021 tttgtttgtg ccaattattc tctaatacat tatatgaata aaaatgattt aaaacttgaa
     4081 gcttgtggca atttaccata tttaaaattt acatcaaaag ccattggaaa cggtaattca
     4141 ttacaaacat ctgtaactac taatttggct agggtatcaa cagacacaaa attcattttt
     4201 aagattaaat ataaagataa tgtagtaaga aatatagtac ttgaaaagta ttttaatagt
     4261 tcgaaagtat taattagaaa agataaagaa gaacttaatg aatattttaa aaatcaaggt
     4321 tacacagttt ttaatatgag tactgatgag gttgtttttg ttaataatag caataggtat
     4381 agttataaag ctaatagata ttttttaggc gtgtatagcg acatggtaac aatatataaa
     4441 acagatgaaa atggaaacat agcagcgagt aaactattta atgctaacgt ttattcagca
     4501 gatggcaaac agcagaaata tgattttgaa gctatagaca aaggcgaatt acaacatatt
     4561 aaaataatcg acctgaaaga aaaagatgga ctagtggaag atcttattcg cggcagaaaa
     4621 tatagcaaag atgatgatac taaaaaagat atgaaagata gcgaagaata tgaaaaagga
     4681 gaattcaaat ctccagcaaa ggcttttgat tatgctatgg gtctattaaa gtcatgataa
     4741 attaatttga atcaattaaa ttatctcctg cggagctgta atattaacga cttcagaagg
     4801 agatgttata ctaccaatga agttttttat tcattagggt atgtaacacc ttttatagaa
     4861 gtggggaact ctccttctaa aatgtcgtta aaataataaa atatgtaata tatcattagt
     4921 aaatatattt tctaaaagga taaaacttta agaaatgtat ttttctaata aaaaagcctt
     4981 aagaaatatg tatcttaagg ctttttacca tgtttttttt attttcatgt atcttattta
     5041 ttgaattaat aacgtttagg tggtaaagta atatatgttg ctataaaaat agaaggataa
     5101 caattaataa ttagtatcct aaaggaagca gcaaggagga agtattatgt tcgaatatat
     5161 aaaaggcatt tttgtaggtt ttaataaaga ctatatcata ctggacaata acggtatggg
     5221 ctatagaata tatacttctg gaagtactat ggctaagatg cctaaaacaa atgaaacggt
     5281 attattatat ataaagcaaa ttgttagaga agattttatt ggtttgtatg ggtttctaac
     5341 aaaagatgag atagagatgt ttagccttgt aattagtata aacggagttg ggtcaaaagc
     5401 tggtttatca ttactttcta tttgcagtgt aacgaattta aagtatgcta ttgtatcagg
     5461 tgatgaaaaa actctaatca gggcaccagg tataggcaaa aaaattgctc aaagaataat
     5521 tttggaactt agagaaaaga tacatcttga gcagtctacc actcaagatc tatctcgaaa
     5581 tttaggaatg aatttaatag aggatagaaa acttagggag gttttgggtg ctcttatttc
     5641 actaggatat tctgaaaaag aatcggaaaa ggcaatgagt gctgtaagtc atgaacaatc
     5701 actcgaaaat ataattaaag attgtttgaa atatttaatg aactaaggtg ggaatatact
     5761 atggatgata ctgaggaaag aattattact tcgtctatca cagaagaaga tgtggatgct
     5821 gagtattctc taagacccca aaagcttgga gaatatattg gtcaatccaa aataaaagaa
     5881 aaattaagta tatttattaa agcggctcaa aatagagatg aagctcttga tcacgtgctt
     5941 ttatatggac cgccaggcct tggtaagaca actcttgcga atattattgc gaaggaaatg
     6001 aaaggcaatt taaaagtaac ttctggacca gcaatagaaa gagctgggga tttagcagct
     6061 attttaacta gccttagtga ctatgatgtg ctttttattg atgaaataca tagacttaac
     6121 agatctgtag aagaaatttt atatcctgct atggaagatt atgcacttga tattgttata
     6181 ggaaaaggag catctgcaaa atccataaga ctagatcttc caagattcac acttattggt
     6241 gcaacaacta ggattgggtt attaactgcc ccacttcgtg atagatttgg agtgctaagt
     6301 gctatggaat attattccgg aggcgaatta aaagaaatag taatacgttc agcagctatt
     6361 ttgaaagtgg atattacgag tgatgctgcg gtggaaattg caagacgttc aagggggact
     6421 ccaagaattg caaatcgttt gcttaaaagg gtaagggatt attgtgatgt taagggaaat
     6481 ggaattatag atcttaatat agcaaaatct gcatcagagc tacttgaaat agatgatgaa
     6541 ggttttgata ggatagataa caaaatgctt gaagctatta tagataattt taatggtggg
     6601 ccagttggta ttgaaacatt atcatatttt gtaggagaag agataggtac acttgaagat
     6661 gtttatgaac catatttaat tcaaaaggga tttataataa gaacaccaag gggacgagta
     6721 gcttctaaaa aagcgtatca acatttaaat agacaacaaa agacatagaa agcaaagaaa
     6781 cttaaataat tcataatata attatgatag acataaaatt taaatgattt ttgcataaag
     6841 aaagggtgta atattttgaa agtaaaggat ttttattttg acttaccaaa ggaacttata
     6901 gcgcaacatc cacttgaaaa aagggatgag tcgaggctta tggtaatcaa taaaactaaa
     6961 aaagaaatag accataaaca ttttaaaaac ataatagatt atttgaatcc aggtgattgt
     7021 ttagtattga atgatactag agtattgcca gcaaggcttc ttggagttaa agagggaacc
     7081 ggtggtaaga tggaattctt gcttcttaaa agaatagata ttaacaagtg ggaaacttta
     7141 gttaagcctg gtaaaaaagc aaagatagga gcaaccttta tttttggtaa tggtgagctt
     7201 aaagcgactg ttattagtga ttcagagggt ggaagcagaa tcgttgaatt tgaatatgat
     7261 ggaatttttg aagaaatttt agataaactt ggagagatgc cacttcctcc ttatattact
     7321 gaaaaattag aagataaaga aagatatcag actgtatact cgagagagga agggtccgca
     7381 gcagctccaa ctgctggact tcattttaca aagcagttac ttgctcaaat caaggctaaa
     7441 ggtgttaaaa tcgcttttgt aacattacat gtaggtctag gtacttttag acctgtaaaa
     7501 gcagaagaag tcgaagaaca tgaaatgcat tcagagcatt atatgttaaa tagtgaaacc
     7561 gcacagttaa taaatgaaac aaaggaaaat ggcggaagag taattgcggt aggtacaact
     7621 tctaacagaa cacttgaaag tatagcaaat gataatggaa gagtatgtgc gaaatctgga
     7681 tggacagaca tttttatata tccaggatac aagtttaaaa ttgttgatgc attaataact
     7741 aattttcatt tgccagaatc tacactaata atgttggtta gcgctttcgc agataaagat
     7801 ttaattatgg gagcatatga agtagcggtt aaagaaaaat atagattctt cagttttgga
     7861 gatgcaatgt ttttatatta aaaagtgata gtaaagaaag agctaactcg taattattgt
     7921 atagaaagta ggttaattat gtataaatta cttaaaaaaa gtggtaaagt aagacgtggt
     7981 gaatttacaa cacctcatgg cactattcaa acacctgtat ttatgaatgt aggtacacta
     8041 gccgtaatta aaggtgccgt atccactatg gatttaaaag aaattaactg ccaagtagaa
     8101 ttgtctaaca cctatcattt acacttaaga ccaacagata cggttgtgcg taaaatggga
     8161 ggacttcata aatttatgaa ttgggatagg cctatactta cagattcagg tggtttccaa
     8221 gtgttttctt tatcaaaaat gagaaagatt aaagaagaag gagtttactt taattctcat
     8281 attgatggga aaaaaatatt catgggtcca gaagagagca tgcaaataca aagcaattta
     8341 gcatctacta ttgctatggc atttgatgaa tgtataccca atccttctac caaagaatat
     8401 gttgtagatt cagtagcaag aactacaagg tggctcgaga ggtgtaagat tgaaatggat
     8461 agattaaatt ctttaagtga cactataaat aacaaacaaa tgttatttgg tataaatcaa
     8521 ggtggaacat atgaggatat tagaatagag catgctaaaa caattagtaa aatggaccta
     8581 gatggttatg ctattggtgg ccttgcggtt ggagaatccc acgaagaaat gtatagaatt
     8641 attgatgcag ttgttccgca tttaccacaa gataagccga tatatcttat gggggttggt
     8701 tatccaagta atatattaga ggctgtatca aggggagtag acttctttga ttgcgtattg
     8761 ccagcaagaa acggaagaca tgggaatgtt tttacgaaag atggtagaat aaatatgttt
     8821 aatgctaaat ttgagctaga tgctggtcca attgatgagg gatgtaagtg tccaacatgc
     8881 aaacattata ctagagccta tataagacat ttatttaaag caaaggaaat gctcgcaatg
     8941 agactttgtg tacttcataa tttatatttt tataataaac ttatggaaga tattagagat
     9001 gctattgata atgattgctt tgaagaattt aaggctgaaa aacttgctca atggaatgaa
     9061 ggaaaataat tatttgctat aatatgatta gcctataaga tatatcttta taggaaaatt
     9121 attttattat aagttagaga aaaaaatatt gaaaggagga gaaaatagat gggacaatta
     9181 ggaagtgtgt ttacaatggt attaatgcta gcagtatttt atctagtaat atttatacca
     9241 gaaaacaaaa gaaagaaaaa atatgctgca cttttaagca acttaaaagt aaatgatgaa
     9301 gtacttacta aaggtggtgt gatggggaaa atcatcaaca tccaagatga gtatattata
     9361 ctagaaagtg gtccggacag aactagaatt aaattagcaa aaagcggaat tggaactgtt
     9421 attaatttaa atactaatga agtagtagag aaaaaatagt gaattatgta ataaaacccc
     9481 ttttcaaatc ataattaata ttatagattt taataaaaaa attgtttatt tattggaatt
     9541 tatagaaaag ggggggattt acatggaaaa taaaaaaaag tattcttacg ctggagaagg
     9601 agtttttagg gcttcaattt taaccctaat tatattagtt atttattcta tagtaacaac
     9661 tgttttgcca gctagcatga aggttacatc agttttttat attgtaataa cactcgtgag
     9721 tgtgctttac ggatctatat tcgctgcgaa aaaagcaggg gaaaaaggtt ggctaatggg
     9781 tattatggtt gctgcgactt acatgttaat tttgtactta gttaaagtct ttggtggtgg
     9841 aagtgctgct attgggatgc gcgaaatagt aagaacgtca ctcgctttag gcataggtac
     9901 cttatcagga atgcttggaa taaatttata aaattacttt atttagctag aatattatga
     9961 tatgatgtac aggtcaactt tatgatatgg aggaatgaaa atgaaacata taaaaactat
    10021 aaatgcagca acaatcaaag aaagtttaaa aaaaccagga tgcaaggaat gtgctaattc
    10081 atgtcagtca gcatgtaaaa cttcttgtac agtagctaac ttagcttgtg aaaactaata
    10141 atgttaacgg gggcagtaac ttagggttac tgctttaaat ttagttagga ggaagaaaat
    10201 tgtcacttat tcataaattt atccaagata atgaacacta tgtaattgat gtaaattctg
    10261 gagcactaca tatggtagat gaaatagttt atgatctttt agatgaaaat gaacttagaa
    10321 aaaaagaaga tttaatagaa gattttaaga ataaatattc aatagaagat attagcgaag
    10381 tatatgacga aattcaaagc ttaattcaag aagaaacttt gtacacagga gatttataca
    10441 aatcaattgc attaagtggt gcaaaagagg agccatatat aaaggcactg tgtctaaata
    10501 taattcatgc ttgtaactta agatgtaagt actgttttgc tgacgagggt gagtaccatg
    10561 gcgctagaaa agcaatgtca gtagaagttg gaaagaaatc aatagatttt gttttagaga
    10621 aatctggacc tagaaaaaat attgagatag atttatttgg tggagaacca cttatggctt
    10681 ttgaaatgat aaaagaaata gttgaatatg ctagggttca ggagaaaatt tataaaaaat
    10741 ccataaggtt tactatgact actaatgcca cattgtttaa tgatgagatc atgaaatata
    10801 tggatgaaaa tatgggcaat atagtactta gcatagatgg aagaaaagct gttaatgata
    10861 aggttagagt aaaggcagat ggaagtggtt cgtatgataa tattcttcct aaaattaaaa
    10921 aaatggttga tatgagagat aaatcaaaac agtattatgt taggggaaca ttcactagag
    10981 ataatactga cttttttgaa gatataaagc atatggctga tttaggattt gaagagatat
    11041 ctatagagcc agtagtactt ccacctgagc ataatctctc acttagagag gaagatttac
    11101 cagtaatatt tgagcaatat gataaattat atacagatat gctcaagaga tataaggatg
    11161 ggacaagctt taaattttat cactttaata ttgatttgaa gggtggacct tgtgtatata
    11221 agagaatagc aggatgtgga gctggacatg aatatgtagc gattactcca gacggtgata
    11281 tatacccttg tcatcaattt gttggcaata aagatttcct tataggagat atatatactg
    11341 ggattactaa taaaaagatg gttaaagaat ttaaagaagc ccatatttat aataaacctg
    11401 cttgcactga gtgctgggct aaattttatt gtagtggtgg atgtcaggca aataacttta
    11461 atttcaacgg agatatgcat ataccatatg aaattggatg caagatgcaa aaaaagagga
    11521 tagaatgtgc tatagcttta aaagcgcaaa ccatgaataa gtaaattata tttaggtgag
    11581 attgactaaa tttgttaatc ataatataat tgcagttatg agtaaacagt gagggggata
    11641 aacatgaaaa agaagaaaag tacgatactg tttctaatca gtgtttgtgt tgttggatta
    11701 ttagcattta caggatttca cggatttaca ataggagact atagggttaa accatttact
    11761 caatcaataa acaaagggtt agacatacaa ggtggaattt cagtactcga agaagttaaa
    11821 ggtggagcgg ttgatgcaaa aactttagat agggctattg aacttatttc tatgagagtt
    11881 aacaaaatgg gaattagtga aacattagtt gccaaagaag gtcttaatag aattagaatt
    11941 gaaataccgg gtaaatttga ttctaaagaa attcttgata ctgtcgctaa atcaggagaa
    12001 cttaaatttg ttggtcctga taaagcaaca attcttactg gtaaagatgt aaaagatgcc
    12061 actgcagcat acggtcaaga taataaacct gttataaatc ttgtacttaa tgactcagga
    12121 aagacaaagt ttgcagcagc aactcagaaa tttttaggac aagtaattac tgtttacatg
    12181 gatgcagatg tattaactgc tcctaaagtg caagtagcta ttttggatgg taaggccgaa
    12241 attaatgggt ttgcaacatt agcagaagct acaacaaaat ctcaaattat taaatcagga
    12301 gcattgcctg tatctttaaa agctgtttca gttaaaacag ttggtgctac tttaggtgaa
    12361 gcagcaatgg cacaaagtat gaaggcggga gtcgtagcaa tattatttgt attcctattt
    12421 atgcttttat attatagagc accaggggtt attgcaaata tatctttatt gttatatgtt
    12481 gttttggttc tcggagcatt ctcagctatg aatgctactt taacactttc aggtattgct
    12541 ggattcctac ttacaattgg tatggcagta gatgctaatg tgttaatatt cgagagaata
    12601 agagaagaac ttaaaactgg aaaatcaata aaatcttcag tacatgctgg tttccataga
    12661 gcacttccat caatattaga ttcaaatata acaactatag ttgcgggttt agttctttat
    12721 atgatgggaa cgggttcagt taaaggtttt gcactaacac tagtagttgg tgtaattata
    12781 agtatattta cagcacttac atgtactaaa tttttattga aattagcagt tgaaatggga
    12841 ctaataagta aaacatctca ttttggcgta aagagggggt aaacatatgc taaagatagt
    12901 tgaaaagact aaactatggt tttctatatc tctaattata attataatag gaatgggggt
    12961 catagcaact aaaggtctaa acttaggtat agattttaaa ggtggtacag caattactat
    13021 aaatatgaat caaaaatttg ataagtcaga tgtagataaa ataattgata aacatgcaaa
    13081 gggtgaatat ttatccaaaa caataaatga tgctaaagaa atcgaaataa ctgtaaaaag
    13141 cgatgctctt tcagctgatg aaacagcaac catgttaaaa gaaattaaga cacaatttaa
    13201 atctagtact ttagtttcgg aagatacaat tggtgcatct attggttctg aattaaagac
    13261 aaaagcagtg agtgctttaa ttgttgctat gcttttcatg ttagtttatg ttggttttag
    13321 atttgaattt aaatttgcag cttctgcaat acttgcatta gtacatgata tattaattac
    13381 tattacagta tatgcagtat ttcaaacacc agtaaatgca acatttatag ctgctattct
    13441 tactgtagtt ggttattcta ttaatgatac tattgttata tttgatagaa taagagaaaa
    13501 tcagagaatt atgagaaaag caactataga agagattact aatactagtg ttacacaaac
    13561 aatggctaga tcaataaata cagttgttac agttttaatt tgtatatttt cggtatgggt
    13621 attggtacca gctataagag accttagtgg cccattgtta attggtatag gagttggatg
    13681 ttattcttca atctttatag caagtcctat gtgggcattt cttaagaaaa gaactaagaa
    13741 agtaactgca taatcgcaat taatagttcg attcaaacaa ttaaaaacaa aagacagaga
    13801 agtatgatgt attaattact tctttgtttt ttttatttta catattagaa aactataact
    13861 atatattttc tattaatatc gaggagtttt tatggtggat ttttttaaag acatacaaaa
    13921 gaataataat gattttatag aatataacat gtataatcca tttttattaa agggaatgga
    13981 ggatgcatta aaaaggatta taaaagcgat aaatcataga gaaaaaattg tcttatatgg
    14041 attttatgat gtggatagta ttactgcaat atctttgttg atgttagttt taaagtttgt
    14101 aaatgctgat gttgagtatt ttataccagg tgaacttagt gaaaatcgcg atttagttga
    14161 aaaagatatt actggtcata taaaatattt aggacctgga cttataataa cgttaggttg
    14221 tggtactaat tcttttagtg aagtagaact atgtaaaggt attgggatag acgttataat
    14281 aactgatttt cacaaaccaa ttaaacacgt cccacacact atagttgtca atccaaagca
    14341 aaagggatgc aaatacccgt ttaaggaatt atgcacctgc gggatgacgt ttaaactggc
    14401 tcaagcgatt tcaacttact acaagatgaa atctgttaac aaatatatgg atttggtaat
    14461 gataggtact atatatagca ggaaaaagat tgaaagtgaa aataaaataa tagtcgaaga
    14521 aggtataaag caattaaatt gtacaactaa ttatggaatt tgtgcattga taaaaataca
    14581 taatattaat attattaatg aggcgacagt tctaaaatta gcatccacag taaaaccaac
    14641 aattaatcct gttggaaaaa tggataatgc taaaattgtt gtcgagttat ttataacaac
    14701 agagaaaaat agggcactac aaatatcaaa atatttagat aaggaactta aaaatagtat
    14761 ataatgttta gtatatggca agagtaaaaa taatgtattc tttatgtatt tgtgtaaatt
    14821 atttaattta gggggataac aatggaactt aaaaatagca ttagagtaat agaaaacttt
    14881 cccaaggaag gtattagttt taaagacata actaccatat tacaagatgg aaaggttctt
    14941 aagcagacaa tagatgatat tgttgaatat ttaagagata agcaaataga tgttatagtg
    15001 ggaccagagg caagaggctt tttatttggg gtacctgtag cctatgctct tggagcagga
    15061 tttgtaccag ttagaaaacc tggtaagtta ccttatgaaa cgctgcaaat tgagtatgaa
    15121 cttgaatatg ggacggataa acttgaaata cataaggatg caataaagcc tgggcaaaga
    15181 gtggttattg tagatgattt acttgctact ggtgggacag ttgcagcggt tacaaaactt
    15241 atagaagaaa tgggtggaga tgttatttct ttaaattttg taatagaact tacaggtctt
    15301 catgggaaag agaaacttaa ggattatgat ataatgtctc ttgtaaaata taacagttag
    15361 tctagtttat ttagtgaata aattagaatt gcataattct acaaattact atataatatt
    15421 agtaaaaagt attggctggt tatttaacca gcctttgatt ttaggagtgt ataagcatgt
    15481 tagaaaaatt attatctaag attgaaaata attgtaataa tgtagacaaa gaccttatta
    15541 ttaaagcatt taatttttct tatgccgcac ataaagagca aaagagagaa tctggtgaac
    15601 catatatagt tcatccagta gaagtagcat gtattttagc agaaatggga cttgatacta
    15661 gtacaattgt tgctggctta cttcatgatg taattgagga tacagtatat acttttgaag
    15721 atgtaagcag agaatttaat atagaagtag caaatttagt ggaaggcgtt actaagcttg
    15781 gtctcataaa atataagact aaggaagagg aacaagctga taatgttcgt aaaatgttac
    15841 ttgctatggc aaaagatatt agagttattc ttattaagct tgcagataga cttcataata
    15901 tgcgaacgct taaatatatg ccgattgcaa aacaaaaaca aaaagcaaaa gaaactttgg
    15961 atatctatgc tccgctggca cacaggcttg gaatgtctaa aataaaatgg gaacttgaag
    16021 atttatcact taggtattta aacccaaatg aatattataa tctagtaaga aaaattgctg
    16081 aaaaaagagt tgagcgtgaa gataacatta acaatataat ggaggaatta aaatataact
    16141 taaatattgt tggaatagaa gctgaacttg atggaagacc aaagcatttt tacagtatat
    16201 acagaaagat ggttacccaa aataaaacta tagatcaagt ttttgatttg actgcagtta
    16261 gaattttagt taatgatatt ggcaattgct atgctgcttt agggatagta catacagttt
    16321 ataaaccaat tccaggaaga tttaaagatt atattgctat gccaaaacct aatatgtatc
    16381 agtcacttca ttcaacagta ataggaccac atgggaaacc ttttgaaata cagattagaa
    16441 cctatgagat gcacaaaact gcagagtatg gtattgcagc tcattggaaa tataaagagg
    16501 gtacagatca gagtgatgat aaaaatcttg attctaaact ttcatggcta aaggatattc
    16561 ttgaatggca aggagaaact tttgatgcag aagaatttat ggaaggtttt aaaattgatt
    16621 tattctcaga tgaagttttt gtatttacac caaaaggtga ggttattaac ttaccattag
    16681 atgcaactcc aattgacttt gcatatagaa tacatactga tattggtaat aagtgcatgg
    16741 gtgcaaaagt aaatggaaga atggtgccac ttgaatatca cttaaaaact ggagaaatag
    16801 ttgaagttat aacttcacct acggctaagg gtcctaatat tgattggcta aatattacaa
    16861 aaagtaatca agctaagagt aaaatcaagg cctggtttaa aaagtcaaaa agagaagaaa
    16921 gcattgaaaa aggtaaagaa ttattagaac gagaatccaa aagacaagaa tataattttg
    16981 gagtgattgc taagggcgaa gcaatagaaa aaatatataa aaaatataac tttagaagtt
    17041 tagatgattt atttgcatat gttggagtgg gagatattat gccttcaact gtagttaata
    17101 gattgaaaga agtttatgag aataaaaaca aacaagaaaa catgacggtt gaggatattg
    17161 aggaaaagat aactaagact ataggcaaag atgataaaaa gaaattggat tattcaggat
    17221 taatagttaa aggtgaagga aatctacttg tacgtttcgc taaatgctgt aacccggttc
    17281 caggagacga aataataggt tatataacaa tgggacgtgg agtttctgtt catagacgag
    17341 attgtaaaaa cgctaaatcg ctaatgacta atgatgcaaa taaggtggtt gaagtaagct
    17401 ggggagcttc agaggggaaa ggttatatta ccgaaattca aattaaagca gatgacaaat
    17461 atggtctatt atctagtata atggagataa taacattaac aaaaacccaa ctttattcaa
    17521 taaatgcaaa aactttaaaa aataatgttg ccttaataaa tataaagtta aaagttgcag
    17581 ggatagataa tttgaaagaa ttacaaaaga aaatagctaa attatctggt gtattagaag
    17641 tttataggat taaaaattaa gaattgtttt attttattta ggagatgtat ttatgagagc
    17701 agtagttcaa agagttaaat catcaagggt tgaagtgagt ggcaaagtag ttagtgaaat
    17761 agggctgggt ttaaatgttt tagttggaat atgcgatgga gacacaatag atgatataaa
    17821 gtacttaaag gataaaattt taaatcttag aatttttgat gaagataata aaatgaacaa
    17881 atctttaata gatgttggcg gagaacttct tatagtctca caattcacat tatatggaga
    17941 ttgtagaaaa ggcagaagac caagttttat gagagccctt ggtggtcagc aatccgaaaa
    18001 attgtattta gagtttgtaa aacagtgctc agaagtaata ggcgaagtta aaactggaga
    18061 atttggggcg gatatgcaag tttatatcca aaatgatggc ccagtaactc tacttttaga
    18121 gagtaaaaaa gatttctagg aggattagaa tggaaattaa aaaagttata gcaggaatat
    18181 atggagccaa ttgttatatt gtaatggata agaacacaag tgaagcggta gtgattgatc
    18241 caggtggaga tgttgatgat attgttaaag taataaacaa tatgggtgcg aaagttaagt
    18301 atatactttt aacacatggt catgtagatc atacatcggg ggtttgcgaa cttaaagcaa
    18361 taacaaatgc aatagtttgt ataagcaaaa aagatgatga tttaataact aaaggtgagt
    18421 atttatttgg acctcttatt aaaggtggtg cagataaatt attaagtgat ggtgatataa
    18481 taaaaattga aaacattcaa attaattgtg tagatactcc agggcataca ccaggtggca
    18541 tgagcttttt aacaggcaaa tattcgttta ctggtgatac actttttgca ggttctattg
    18601 ggagaacaga tttcgtagga ggagatttta atgctataat taatagtatt aaatcaaagc
    18661 ttttatgcct tccaggcgac actttggtct atcctggtca tggacctggt agcacaataa
    18721 ataaagaaaa attaaataat ccatttttac aggattaata tggtgtataa tatattatga
    18781 tattatacgc tatgtttatt aaggagttaa gatgataaaa gtaaaattaa gtaatgaaca
    18841 atttaattat gatgtatttc aaatcataaa tttattttat tttttcccag atattaaatt
    18901 cgtagaagaa gattatgatt ttaatattaa tgtaggagaa actgtaatag atatacaagg
    18961 ggagcctgaa agttttaagt attttgttaa taatgcatat aaacttaagg atgaagttaa
    19021 aaaggctgtt tttatatatt tttcaaaaaa cacaactcag gaacttccat ggggtacaat
    19081 aatagggatt agaccttcta aaaaagctct tgacttgctc gaaaggggag taacagacga
    19141 taaaataatc gcagagttta aggaaaaaca tgttacaagg gaagataaag cacaactttg
    19201 tattgatgtt gcaaaatttg agcgaaatat cgttaataaa gaaaaaaata atgtaagtat
    19261 ttacattgat atgccgtttt gtcctactag gtgtatatat tgttccttta cttctaatcc
    19321 tataggtaaa tgcaaaaatg ttgttatgcc ttatcttgag gctttagccc atgagattaa
    19381 gagtgtaggt gagtatatac gcgaaaagaa gttaaatata gaatgtgtat attttggtgg
    19441 gggtacacct acagcaataa acaatgaaca atttgagttt ataatgaatt atatatatga
    19501 tgcttttatt ttgcaaaaca atgtgcgaga atttacagtg gaatgtggaa gaccggatag
    19561 cataacacgt gaaaaattaa ttactatgaa aaaatatgga gtacatcgaa taagcattaa
    19621 tcctcaaaca atgaatgatg atacactgga attaattgga agaaaccact gtgtagaaga
    19681 tgttttcgaa aaatttgaaa tggcaaggga attagggttt aataatataa atatggattt
    19741 gatagtaggt ctacctggag aaaaaatttc acatatgatt aaaacttgta atgaaattta
    19801 taagattaaa ccggatagta ttacaattca tggtatgtct ataaaaagag cttcaaggct
    19861 tcatgaaaat atgcttaata attatagatt tgaagttcca gggcaagaag aattaaataa
    19921 aatgtatggg cttactgtag aattaacaaa aaaacttgat atgaaaccat attatatgta
    19981 taagcagaaa aatatgatag gtaatatgga aaatatagga tatacaacgc tttctaaaga
    20041 aggaatctat aatattcaaa tgattgagga aaaacagaca gtcattgcac taggtgcaga
    20101 tgcagtttct aaagtcgtgt ttttagatga aaatagacat gaaaggttcg caaacgtaaa
    20161 ggatgttcgt gaatacataa aaagagtaga tgaaatgatt gataagaaaa ttgtattact
    20221 aaatacatta tatacttaaa atataatgta tattaaagcg cctaagggta ttgatttaag
    20281 tgttaatata atttatcaaa gggaaggaga aaaataaaat ggcagaagcg ttaaatggtt
    20341 taaagagaac caatatgtgt ggagatctta gagaatcaca catatcaaat acaataacag
    20401 taatgggctg ggttcaaaga aaaagaaatc ttgggggact tgtttttata gatttaagag
    20461 atagaacagg aatacttcaa ttagtatttg gagaagaaat aaacaaagaa gcttttgaaa
    20521 aagcagataa agtaaaacca gagtactgcc ttgctgtaac tggtgaactt gttaaaagac
    20581 aatctccaaa tgaaaatctc ccaactggac ttgtagaggt taaaggcgag aacataaaaa
    20641 tattgtctga atcagaaaca ccgcctatat atataaaaga aggtctagat gcagcagaaa
    20701 atatacgtct aaaatacaga tacctagatt taagaagacc agatatgcaa aaaatattta
    20761 tgatacgatc taaaacaact aaggttgttc gtgatttttt agatgaaaat ggattcttag
    20821 aaatagaaac acctatgctt acaaaaagta ctcctgaggg tgcaagggat tatctagtcc
    20881 caagtagaaa ttacccaggt atgttttatg cacttccaca atcaccacag ctatttaaac
    20941 aattactaat ggtttctgga tatgataaat actttcaact tgcaagatgt tttagagatg
    21001 aagatttgag agctaataga caaccagagt ttacacaaat tgatatagag atgtcgtttg
    21061 ttgaagaaga tgatgttatg gctattaacg aagcactaat caaaaaagta tttaaggaag
    21121 ttgtgaatga agatgttaaa cttcctataa ggcgaatgaa gtataaagaa gctatgagta
    21181 aatatggttc agataagcca gatataagat ttggaatgga aattaatgat attacaagcg
    21241 ttgtaaaaga ttctgaattt gtagtgttta aaagcgctat agaaaatggt ggctcagtaa
    21301 gagctataaa agttgagaat gctgcagata tgggaagaaa aaaattagac aaatttggtg
    21361 agtttgttaa gacttataga gcaaaagggc ttgcctggat tgcatgtaaa gaagatggga
    21421 taaaatcacc tatggctaag ttctttaatg accagcaaat gcaagaaata ctcgataagg
    21481 ttgaggcaaa aactggagat ttagtgctta ttgttgcaga taaggatagt ataacactac
    21541 aaagtttagg agccttaaga ttac
//
