LOCUS       NZ_CP086140            20870 bp    DNA     circular CON 20-JAN-2024
DEFINITION  Clostridium estertheticum strain CF016 chromosome, complete genome.
ACCESSION   NZ_CP086140
VERSION     NZ_CP086140.1
KEYWORDS    RefSeq.
SOURCE      Clostridium estertheticum
  ORGANISM  Clostridium estertheticum
            Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 5053333)
  AUTHORS   Wambui,J., Stevens,M.J.A. and Stephan,R.
  TITLE     Clostridia strains as spoilage organisms
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5053333)
  AUTHORS   Wambui,J., Stephan,R. and Stevens,M.J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2021) Institute for Food Safety and Hygiene,
            University of Zurich, Winterthurerstrasse 272, Zurich, Zurich 8057,
            Switzerland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2021
            Assembly Method                   :: unicycler v. 1
            Assembly Name                     :: CF016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Nanopore/Illumina miniseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/20/2024 05:10:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,249
            CDSs (total)                      :: 5,114
            Genes (coding)                    :: 5,019
            CDSs (with protein)               :: 5,019
            Genes (RNA)                       :: 135
            rRNAs                             :: 15, 14, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 14, 13 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 22 of 95
            Pseudo Genes (incomplete)         :: 78 of 95
            Pseudo Genes (internal stop)      :: 14 of 95
            Pseudo Genes (multiple problems)  :: 16 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:27:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1953803
            Orig. end                         :: 1974673
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086140.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20870
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20870
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20870
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10870](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10870
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    250..264
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.89"
                     /tool="antismash"
     misc_feature    391..407
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.1"
                     /tool="antismash"
     gene            530..1087
                     /gene="efp"
                     /locus_tag="LL065_RS09365"
                     /old_locus_tag="LL065_09350"
     CDS             530..1087
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="efp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101597.1"
                     /locus_tag="LL065_RS09365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09350"
                     /product="elongation factor P"
                     /protein_id="WP_071613316.1"
                     /transl_table=11
                     /translation="MISAGDIRKGTTFDEGGQVYTVIDFLHVKPGKGAAFVRTKLRNVI
                     NSGVTEKTFNPTTKLQEAVIERKEMQYLYAADGLYYFMDQETFEQIPLNYEKVEEAIKY
                     LKENMFAIIKFYKDEAFSVEAPNFVELLITSTEPGVKGNTSSSVTKPATVETGAIIQVP
                     MFVNEGETIRIDTRNGDYMLRV"
     gene            1257..2177
                     /gene="spoIIIAA"
                     /locus_tag="LL065_RS09370"
                     /old_locus_tag="LL065_09355"
     CDS             1257..2177
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012620361.1"
                     /locus_tag="LL065_RS09370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09355"
                     /product="stage III sporulation protein AA"
                     /protein_id="WP_226138080.1"
                     /transl_table=11
                     /translation="MLVTKDLFEILPKTIRNILEKVDNVQQLEEIRVKVNKPLFIHIGS
                     KEKVWEYIATPEDLKYIMQRISNYSIYAFEDEIRQGYITIKGGHRVGLCGICVIENNSI
                     KTIKDISSINIRACKEIIGCADKVMPYIINNNSVYNTIIISPPKCGKTTLIRDISRQIS
                     QGYKDMSFRGKNVSIIDERSEIAGSFKGIPQMDVGVRTDVLDNCPKSQGIMMAIRSMSP
                     DVIVCDEIGTKNDMESILMALNSGISLITTIHGFGIEDLYKRLVFKDIVDNYVFTRGIV
                     LSNKKGIGTIERIYDFTKGIDVWRS"
     gene            2179..2697
                     /gene="spoIIIAB"
                     /locus_tag="LL065_RS09375"
                     /old_locus_tag="LL065_09360"
     CDS             2179..2697
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015615973.1"
                     /locus_tag="LL065_RS09375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09360"
                     /product="stage III sporulation protein SpoIIIAB"
                     /protein_id="WP_226138081.1"
                     /transl_table=11
                     /translation="MIKIVGCLVILVASTMAGFIYSERLKYRVFQLNEIQRAVYQLQNE
                     ITYVHALLPDAFKSIAGKSKEPINELFNKTSELLTNNEYENVYEAMNSAINLTKDKLYI
                     NSDDINVILDLSKTLGESDIQGQNSMFLLTIANLKKQITISEEYMNKNIKMYRCLGFSF
                     GAMIVIVLI"
     misc_feature    complement(2227..2245)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 27.69"
                     /tool="antismash"
     gene            2713..2910
                     /gene="spoIIIAC"
                     /locus_tag="LL065_RS09380"
                     /old_locus_tag="LL065_09365"
     CDS             2713..2910
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003365078.1"
                     /locus_tag="LL065_RS09380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09365"
                     /product="stage III sporulation protein AC"
                     /protein_id="WP_071613313.1"
                     /transl_table=11
                     /translation="MLDVSLLFKIGAIGILIIIIDKILKSGGKDDIAVVANLAGVIIIL
                     MMVINLVNKLFTSVKTLFQF"
     misc_feature    2732..2748
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.45"
                     /tool="antismash"
     gene            2971..3354
                     /gene="spoIIIAD"
                     /locus_tag="LL065_RS09385"
                     /old_locus_tag="LL065_09370"
     CDS             2971..3354
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004451828.1"
                     /locus_tag="LL065_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09370"
                     /product="stage III sporulation protein AD"
                     /protein_id="WP_216104780.1"
                     /transl_table=11
                     /translation="MEIIKVVAFAFIALFIVLIFKGRRDDLAIQVSIAAGILIFLFMVN
                     KLTIILGFLQTLANKANIDVVYLNTVFKILGIAYLASFCSEICRDAGQSNIAGKVEFAG
                     KIFILVLAIPILMAVMQSILKIM"
     gene            3394..4557
                     /gene="spoIIIAE"
                     /locus_tag="LL065_RS09390"
                     /old_locus_tag="LL065_09375"
     CDS             3394..4557
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003358911.1"
                     /locus_tag="LL065_RS09390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09375"
                     /product="stage III sporulation protein AE"
                     /protein_id="WP_226138212.1"
                     /transl_table=11
                     /translation="MKRLNMKKILLILLFLLSLNISVQAAEIGKIGEKQQTEINNLYDY
                     ISNVKSQYEIFNDMQPQTFVEEFIKTGDNGLSFNKTSTFIIRYTFKEVIACMELIGSLM
                     IIAIICAMLNNLQSAFNRESLSNIAYLACYGVMILMITKSFYVVAELAKNTIVSMSNFM
                     SALIPVLMMLLASVGGFAEATLLDPVIMGFATVSSRIYVDIIIPIIFMSFVMQFVSSIS
                     SDYKIKNLTKLLKQTAIWIQGIVMTVFIAVITIRSIAAKTLDQVTIKTAKFAVDTFVPV
                     VGKCLSDAISTVAGYSLLLKSAISGLGLIVLMVIVILPIIKLLIMAFLYKAAAALIEPI
                     SDNRTVECINSVGDSIFLLMSCVISVSVMFFIMVAIVAATGKGIISG"
     gene            4622..5215
                     /gene="spoIIIAF"
                     /locus_tag="LL065_RS09395"
                     /old_locus_tag="LL065_09380"
     CDS             4622..5215
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAF"
                     /inference="COORDINATES: protein motif:HMM:NF021121.4"
                     /locus_tag="LL065_RS09395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09380"
                     /product="stage III sporulation protein AF"
                     /protein_id="WP_226138082.1"
                     /transl_table=11
                     /translation="MIELLKVWVTNITIAIFFITAVEMILPDNNMKKYAKFVLGLMLIV
                     IIIKPIIKIFDKNFDLNSYSNKATSYIEGSTQPSDMKKYKDINIVNTTENFKKNLQKEC
                     ITNLEQTYPENKYNADVDVVYDSKNGVFNINRVKIDVVDSGVQSIKSIKIDTQSVDASN
                     NNILTNTLGKQIKKFLSNKLKISDDVITVYKVNS"
     misc_feature    4651..4671
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.31"
                     /tool="antismash"
     misc_feature    complement(4652..4672)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.31"
                     /tool="antismash"
     gene            5264..5926
                     /gene="spoIIIAG"
                     /locus_tag="LL065_RS09400"
                     /old_locus_tag="LL065_09385"
     CDS             5264..5926
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010292275.1"
                     /locus_tag="LL065_RS09400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09385"
                     /product="stage III sporulation protein AG"
                     /protein_id="WP_226138083.1"
                     /transl_table=11
                     /translation="MNNDNLLSKFTEFIKTKINIGNESSKNDKSKKSDKLLGNILLLIL
                     VAVVIVLASSSFKSSKPTSTEQTTIDTETQKNATAKVTNTAAVNDYEAQLESKLKLTLE
                     GIEGVGKVQVMIYFESGEESVPAVNVNDSKSVTKEDDKAGGTRNITQDNNGSTVVMENN
                     GSANEPLIVKKIKPIITGVCVVAEGSGVKITELRIRQAVINLFNLPENKVNVYPMNK"
     gene            5965..6477
                     /locus_tag="LL065_RS09405"
                     /old_locus_tag="LL065_09390"
     CDS             5965..6477
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017415711.1"
                     /locus_tag="LL065_RS09405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09390"
                     /product="SpoIIIAH-like family protein"
                     /protein_id="WP_226138084.1"
                     /transl_table=11
                     /translation="MNKKQSGIIVTLVVLIVFAGYLATKVNGPLYVNDSDFSNEKSAIS
                     LKDTKTASTASTYFVEAKLSRNQDNDKTLQTIKTLIDDTNTPKDQKATASKQYLNISMA
                     AQNQSDIELALKAQGFEESMCSIVNDKVQVVIKTDKKQLTDEQLRSIKDIVMSKTKLEK
                     IEVKIKQ"
     misc_feature    5966..5982
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.39"
                     /tool="antismash"
     gene            6559..6948
                     /locus_tag="LL065_RS09410"
                     /old_locus_tag="LL065_09395"
     CDS             6559..6948
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007060019.1"
                     /locus_tag="LL065_RS09410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09395"
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="WP_071613307.1"
                     /transl_table=11
                     /translation="MEDKILNETEMGVVKISEDVVSVIAGLAVAEIQGIVGMSASLVGG
                     ITQILSGKKNLSKGVKVNVGENSAIIDLHVVVEYGIKIPEVTEKAQINVKKSVELMTGL
                     VVSAVNVYVQNVVLPKTEKLEEIEA"
     gene            7046..7441
                     /gene="nusB"
                     /locus_tag="LL065_RS09415"
                     /old_locus_tag="LL065_09400"
     CDS             7046..7441
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="nusB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012705735.1"
                     /locus_tag="LL065_RS09415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09400"
                     /product="transcription antitermination factor NusB"
                     /protein_id="WP_226138085.1"
                     /transl_table=11
                     /translation="MNRRKSRETAMKLLFEMSINKEKYEDIIENFKENTDVDLNDLDMS
                     YITKVLAGIHENGKDIDKNIEKYLIKWKLVRLSKMNLAILRISTYEILYEEEIPNRVSV
                     NEGIELAKKYGEDSSPAFINGILAKMI"
     gene            7679..8527
                     /locus_tag="LL065_RS09420"
                     /old_locus_tag="LL065_09405"
     CDS             7679..8527
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015615964.1"
                     /locus_tag="LL065_RS09420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09405"
                     /product="tetrahydrofolate dehydrogenase/cyclohydrolase
                     catalytic domain-containing protein"
                     /protein_id="WP_226138086.1"
                     /transl_table=11
                     /translation="MGIRVNGKIIVETYRDEIKNIIKDGVDRGLRAPSIKTILVGSDGG
                     SLSYVRSQNNLCNKLGISYACTQLEKDISQKDIIGIIEKFNEDNSVDGIIIQLPLPKNL
                     NEKEITSKISYKKDIDGLTDVNMGRFYKGDKSFIPCTALGVIEMIKNTGCNIKGKHAVV
                     IGRSNIVGKPVAQLLLNEDATVTICHSKTTNLKEVCKTADIIVAAIGKPGFVTSEFIKA
                     GAIVIDVGTTMIDNKITGDVNFDDVINHASFVSPVPGGTGLMTTTMLIKNACASWRDNV
                     Y"
     gene            8517..9722
                     /gene="xseA"
                     /locus_tag="LL065_RS09425"
                     /old_locus_tag="LL065_09410"
     CDS             8517..9722
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101611.1"
                     /locus_tag="LL065_RS09425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09410"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_226138087.1"
                     /transl_table=11
                     /translation="MFIKVITVTALNGYIKKVIDSDFILNNANVKGELSNVKLHSSGHI
                     YFSLKDEFGKVNCVMFKSQAQKLVIIPRDGMNVIIRGRVSVYEKGGAYQVYCDSMETDG
                     EGQLFLAFQNLKEKLQKLGLFDEEHKKIIPSFPRRIGIVTSQTGAAVKDIINVATRRNA
                     NVNMLIYPTLVQGVSASSEIEQGIKYFNNSKNVDLIIIARGGGSIEELWAFNEENLAYA
                     IYNSKIPIITGIGHETDFTIADFVCDHRAPTPSSAAEIAVRNLKDLNNEIKSLRELLLR
                     SVEFKFTKEYNKINLLSKTLKVNNPLNFIVSQYTHIDNLRENLNYKFNAKISMEKQKLS
                     KLNALMNAHNPLNVLNRGYAVLQNDENEVISEISILRNIKDVKIILKDGTARFNISNLE
                     EL"
     gene            9722..9943
                     /locus_tag="LL065_RS09430"
                     /old_locus_tag="LL065_09415"
     CDS             9722..9943
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003375054.1"
                     /locus_tag="LL065_RS09430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09415"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_071613303.1"
                     /transl_table=11
                     /translation="MAKKKESYETMMERLEKIVEVMDSNEITLEGTMVNYEEGVKICNN
                     LYKILNDTEGKIKILTDEGEKDFTPHVE"
     gene            10001..10870
                     /locus_tag="LL065_RS09435"
                     /old_locus_tag="LL065_09420"
     CDS             10001..10870
                     /EC_number="2.5.1.10"
                     /GO_function="GO:0004337 - geranyltranstransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013725469.1"
                     /locus_tag="LL065_RS09435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09420"
                     /product="farnesyl diphosphate synthase"
                     /protein_id="WP_226138088.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.5e-55, bitscore:
                     184.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIQLLRESVEKWIDDYFKGKSKKNSKNFEAMSYSIKVGGKRVRP
                     ILMLLTYGMYKEDYRDILPFAAALEMIHTYSLIHDDLPCMDNDDLRRGKPTNHKVYGEA
                     IAVLAGDGLLNEAMVIMLDQCLDGDLNTIKASNIIAKASGAEGMIAGQICDILSEGMKI
                     SEEKLLYMHKNKTGELIKAAVVCGATLGNADETDLCYLKEYGDKLGLAFQIKDDILDVI
                     GDVAILGKNTKSDEFNNKTTFITMYGLEKCKQKCNDLTQECFKILNQIKVNTKYLEEIT
                     ESLLKREY"
     gene            11024..12886
                     /gene="dxs"
                     /locus_tag="LL065_RS09440"
                     /old_locus_tag="LL065_09425"
     CDS             11024..12886
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007060012.1"
                     /locus_tag="LL065_RS09440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09425"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_226138089.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.2e-121,
                     bitscore: 402.3, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-07, bitscore:
                     29.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKILDNFNDINDIKKMTIQELNDFAKEIRHFLVEKVSKTGGHLA
                     SNLGVVELTLSLYNVFDLDKDKLIWDVGHQSYVHKILTGRKDKFDLLRNYGGLSGFPKR
                     EESKYDVFEAGHSSTSISVGAGIARARDLQKGDYNVISVIGDGALTGGMSFEALNDIGF
                     RKTKMIIVLNDNQMSISKNVGGMSKYLSQFRIDPTYNRIKKEINSTLRKIPNVGDGMIN
                     SIQKIKNGIKQVVVPGMLFENMGITYLGPIDGHDIKEVSKVLKLAKKTDGPVIIHVITK
                     KGKGYKFAEEQPNKFHGVGPFNPSNGELCSSHKESYSEAFGEQIVTLAKKNKNIVAITA
                     AMPEGTGLESFSKEFNNRFFDVGIAEQHAVTMAAGMASQGLKPIFAVYSTFLQRAYDQI
                     LHDVCIQNLPVIFAIDRAGIVGQDGETHQGIFDLSYLSHIPNMTIMAPKCIGELKTMLT
                     FAVKQDYPIAIRYPRGGDNPNVKMSPINDLQRGKWETLLAGGKIAFIATGKMVQNAILV
                     REKLLNMGIESTVVNACFIKPIDKKLLLDLVDKKYSLVTIEDNVVHGGLGSLVLEYVNS
                     LNKNTKVINLGFNDEFIPHGSVDILYKLYKLDVDGIFDSILKLV"
     gene            12919..13746
                     /locus_tag="LL065_RS09445"
                     /old_locus_tag="LL065_09430"
     CDS             12919..13746
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010237998.1"
                     /locus_tag="LL065_RS09445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09430"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_226138090.1"
                     /transl_table=11
                     /translation="MIENKERLDVIVVERGILFSRERAKENIIAGNIFVDGIRTTKCGK
                     KIDVTSSIEFIGKDIPYVSRGGLKLKKAIDAFKIDLKDKVCLDIGASTGGFTDCMLQHG
                     ACRVYSIDVGINQLDDKLRGDSRVVSMEKTNIRYLNKDSICELADFASIDVSFISLEKV
                     IPNLLNLLKNDGSVVALLKPQFEVGIGVVNKKGVVKKPSDHIDVIVGVLNLLKSLNVKV
                     INVDYSSIKGPNGNIEYLVYFTKSKNGYDDYVEDNVALLVSDAHRSLNCLKRE"
     gene            13783..14664
                     /locus_tag="LL065_RS09450"
                     /old_locus_tag="LL065_09435"
     CDS             13783..14664
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015615957.1"
                     /locus_tag="LL065_RS09450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09435"
                     /product="NAD(+)/NADH kinase"
                     /protein_id="WP_226138091.1"
                     /transl_table=11
                     /translation="MKNIGININTTKDKDGKIGKYVKDIISQYIDDTNIFVFKDSIGLE
                     DIKYNYLDIIVALGGDGTILRTSRNLNNSNIPILGVNIGNLGFLSSVELLEFESAMKRF
                     INDDYYVEERMMLNCTLPNRNELEKYTALNDIVVSKGTLARVVKYELHIDNKFYIDFTG
                     DGLIIATPTGSTAYSLSAGGPIIYPNLDVIEVTPICPLSLSMRTIVLDSKSEISVNIKC
                     EHESIFLTLDGQRAIKLNSYEKILVSVSEQKCRLVKFNDYNYFGILRKKIISRTTDCEG
                     EKDEDIASCKNN"
     gene            14633..15085
                     /locus_tag="LL065_RS09455"
                     /old_locus_tag="LL065_09440"
     CDS             14633..15085
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101620.1"
                     /locus_tag="LL065_RS09455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09440"
                     /product="arginine repressor"
                     /protein_id="WP_171296859.1"
                     /transl_table=11
                     /translation="MKISRHAKIIEIIQSKDVETQEQLAQELKNNGFDITQATVSRDIK
                     ELKLIKVMNAHGTHIYSTSSPGDSFLSNKLVNIFSQTVLYVDNVDKFIVLKTISGAGAA
                     AAEALDSLKFSGIVGTVAGDNTVFILVRNEEDSKDIIQKVKKMISE"
     gene            15097..16785
                     /gene="recN"
                     /locus_tag="LL065_RS09460"
                     /old_locus_tag="LL065_09445"
     CDS             15097..16785
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014520819.1"
                     /locus_tag="LL065_RS09460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09445"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_226138092.1"
                     /transl_table=11
                     /translation="MLLQLNIMNFALIEKLSINFERGFNVLSGETGAGKSILIDAINYV
                     LGGKFNKSLIRTGENKTYVEAIFTIDNQNNRNVLEEMDIDYEDTVFISRETFQSGKSIA
                     KVNGKSLLLAKVKYISKNLLDIHGQHDNHNLLDKANHIFYVDSFGNERLGTAIIEYNDK
                     YTRMTSIKNRILKLEGNEGERDKRIDFLNYQLEEIKNANLKIGEDEELLEKYAIVSNSE
                     NLEKHLSISYQLLYTSDEENPSVLYNLAIAIKELRTIEKHMDKIKVITDSIEESYFNIE
                     ENITEIRDLKESIYYDEKELEYMNSRISQINNCKKKYGSTIKEIYEYRDKIDVEYEELT
                     NSSEIITSLKKEKIALEGEMRIIADEIHEIRCETAKNLQSKIKDELNYIGLERSKFFIE
                     VKLTDEFYKNGCDKVQFCIATNPGEPLNPLEEIVSGGELSRIMLALKTVFVDKDEIPTV
                     IFDEIDTGISGRIAQCVAEKMYLISLNHQIFCVTHLPQIASMADINYLISKNVINDKTY
                     TNIIRMNDNEKQQEIARMIGGTEVTKLTLENSKEMINLANDRKKK"
     gene            17168..18391
                     /gene="spoIVB"
                     /locus_tag="LL065_RS09465"
                     /old_locus_tag="LL065_09450"
     CDS             17168..18391
                     /EC_number="3.4.21.116"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIVB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015615954.1"
                     /locus_tag="LL065_RS09465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09450"
                     /product="SpoIVB peptidase"
                     /protein_id="WP_226138093.1"
                     /transl_table=11
                     /translation="MKKRLNIFCLLITPILIIALGVCYQSQSIAVSAFDKQIQTLYSNN
                     IINAKVNTNNVLSNHYIIEKGKKVKEDTDNVLKAKLTFVTKNKDIMVYPGGQPIGVKLN
                     TKGVLVVALSDIDGVNGKTQSPASNAGVEIGDSIIKINNIVINHAEDISRFVNKEKNPE
                     LTLKIQRRNGSKIFDIKVKPTIDSTDGKQKIGLWVRDSTAGVGTLTLYDSRTNKFAALG
                     HPITDSDTGTILSINNGVIISSNIVSIKKGTRGTPGELRGLFIDENKIKGQLINNTQCG
                     IFGNGSESLINNKFNKPMKIGLRNEIKEGEAQILTTINGNEPELFKIEIQKLLSQDIPG
                     SKSMIIKITDPRLLEKTGGIVQGMSGSPIIQNNKIVGAVTHVLINKPDVGYGIYIEWML
                     KDAGILSK"
     gene            18590..19408
                     /gene="spo0A"
                     /locus_tag="LL065_RS09470"
                     /old_locus_tag="LL065_09455"
     CDS             18590..19408
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /GO_process="GO:0042173 - regulation of sporulation
                     resulting in formation of a cellular spore [Evidence IEA]"
                     /codon_start=1
                     /gene="spo0A"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007060005.1"
                     /locus_tag="LL065_RS09470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LL065_09455"
                     /product="sporulation transcription factor Spo0A"
                     /protein_id="WP_226138094.1"
                     /transl_table=11
                     /translation="MEEPRISVLIADDNKEFCNILNDYLLSQRDIMVTGIAKDGIEALK
                     LIKERKPDLVVLDIIMPHLDGLGVLERLGSMDLNPIPKIIVLSAVGQDKITQRAIALGA
                     DYYVVKPFDMEVFTKRIRQMFNNTISSDNSSKKSISFIDTTETRKSNRNEPMDLEAEIT
                     NIIHEIGVPAHIKGYMYLREAITMVVNDIELLSAVTKELYPSIAKKFNTTASRVERAIR
                     HAIEVAWGRGQVETINKIFGYTVHNAKGKPTNSEFIAMVADKLRLQNRVS"
     gene            complement(19814..20101)
                     /locus_tag="LL065_RS09475"
                     /old_locus_tag="LL065_09460"
     CDS             complement(19814..20101)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LL065_RS09475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LL065_09460"
                     /product="hypothetical protein"
                     /protein_id="WP_226138095.1"
                     /transl_table=11
                     /translation="MRIETNSSTRIYKDKLSSGNFNNLSNILYIGNEAKIKAYSILVYN
                     HEKNLSQSIHLTIKNMFNLNTYYTNYAACEAKWNKSSNVELNSFLRFLVQ"
ORIGIN
        1 tttggatata gtgatatttt agaatgctta agaaaaaata aagattttaa agtagagtcc
       61 attaatatga tggataatga aaaatgtaat gttgaagtta attacaaagg ggatttaaat
      121 ttattatata gttcattagt taagttaact gaaagcaaaa atttattaaa tgtaagcaaa
      181 attattattc acaaagacac tgaaattaca aatatagaga tcaattttaa aaagaataag
      241 tgattaattg aaatattcgg tccaatttta gggagtggat attttaatta atgattttta
      301 ttaaaatata tacactttaa atggtatact tataaaaaag acataaaatt attcaaataa
      361 tatatattta tatttgcaaa tatccttaag ttttgataaa ataacattgt tccactgtaa
      421 tgtttatatt tagtggagtg caaacgtaat gattggtatt aatttaccta ataaggttat
      481 aatataaatg ggttaattga attatttata aattttggag ggatacttaa tgatttcagc
      541 aggcgatata agaaaaggaa caacatttga tgaaggtgga caagtttaca cagttataga
      601 ttttttacat gtaaaaccgg gtaagggagc tgcatttgtt agaactaagt taaggaacgt
      661 tataaactca ggggttacag aaaaaacatt taatcctact acaaaattac aagaggcagt
      721 tatagaaaga aaagaaatgc aatatttata tgcagctgac ggactatact acttcatgga
      781 tcaagaaact tttgaacaaa taccacttaa ctacgaaaaa gttgaagagg caataaaata
      841 cttaaaagaa aatatgtttg ctataataaa attttataag gatgaggctt tctcagtgga
      901 ggctccaaac tttgtagaat tacttataac tagtactgaa ccaggtgtta aaggtaatac
      961 atcttctagt gtaacaaaac cagctactgt agaaacagga gcaattattc aagtgccaat
     1021 gttcgtcaat gaaggtgaaa ctataagaat agatactaga aatggagatt acatgttaag
     1081 agtttaaatt tctatttaaa aagaaccgat atcatattgg ttcttttttt tgttcttttt
     1141 ttgttaacta atacatatat tatgggaatg aatcggaatt taaataatat gttttaattt
     1201 atatggaata ttatgcaagg caaagaaata caaattatat atgggaggat gagaagatgt
     1261 tagttacaaa agatttattt gaaatactac ctaaaactat tagaaatatt cttgaaaaag
     1321 ttgataatgt gcaacaactt gaagagatta gagtaaaggt aaacaagcct ttgtttattc
     1381 acattggcag taaagaaaaa gtctgggaat atattgcgac tccagaggat ttaaaataca
     1441 taatgcagag gataagcaat tactccatat atgcctttga agacgagata cggcaagggt
     1501 atataactat aaaaggcgga cacagagttg gattatgtgg gatttgtgtt attgaaaata
     1561 atagcattaa gaccattaaa gacatttcgt ctataaatat aagagcatgt aaagaaatta
     1621 ttggatgtgc ggacaaagtt atgccatata ttattaataa taattcagta tacaatacaa
     1681 taattatatc gcctcctaaa tgtggaaaaa caactctaat aagagatatt tcgaggcaga
     1741 tatcacaggg atataaagat atgagtttta gaggaaagaa cgtctctata attgatgagc
     1801 gctccgagat agctggttct tttaagggaa taccacaaat ggacgttgga gtgcgtactg
     1861 atgtactaga taattgtcct aagagtcaag gaattatgat ggcgattaga agtatgtcac
     1921 ctgatgtgat agtttgtgat gaaattggta ctaaaaatga tatggaaagt attttaatgg
     1981 cattaaattc tggaattagt ttaattacaa ctattcatgg ttttggaatt gaagatttgt
     2041 ataaaagatt agttttcaag gatattgttg ataattacgt atttacgagg gggatagtgc
     2101 ttagtaataa aaaaggaatt ggaacaatag aacgtattta tgattttact aagggcatag
     2161 atgtatggag gtcgtaatat gattaaaata gttgggtgtc ttgtaatctt agttgcgtca
     2221 actatggctg gatttatata cagcgaaagg ttaaaatata gggttttcca actaaatgaa
     2281 attcagagag ctgtttatca acttcaaaat gagataactt atgtacatgc tcttttgcca
     2341 gatgctttta aaagtatagc agggaaaagt aaagaaccga taaatgaact atttaataaa
     2401 acaagtgaat tgttaactaa caacgaatac gagaatgtat atgaagctat gaatagcgca
     2461 ataaacctaa caaaagataa attatatata aattctgatg atataaatgt tattttggat
     2521 ttatcaaaaa cacttggaga atctgatatt caaggtcaaa acagtatgtt tctgcttact
     2581 atagcaaatt taaaaaaaca aattacgata tctgaagaat atatgaataa gaatataaaa
     2641 atgtatagat gtttagggtt ttcttttggg gcaatgattg taatagtact aatataggga
     2701 ggaggttttt atgtgttaga tgttagttta ctgtttaaaa taggggcaat aggtattctc
     2761 attattatta ttgataagat tttaaaaagt ggaggcaagg atgatatcgc tgtggttgcg
     2821 aatttagctg gagtaataat aattcttatg atggtgataa atttagtaaa taaactgttt
     2881 acttctgtaa aaactttgtt tcagttttag gataaacaga taaaaatcaa aaacttttat
     2941 tcactcgcag agtctatcga ggagggtgtt atggaaataa tcaaagttgt tgcattcgct
     3001 ttcatagcat tatttattgt gcttatattc aaaggtagaa gagatgattt agctattcaa
     3061 gttagtatag cagcgggaat attgatattt ttatttatgg taaacaaact tacaataatt
     3121 ctagggtttt tacaaacatt agcaaataag gctaatattg atgtcgtcta tttaaatact
     3181 gtttttaaaa tactggggat tgcctattta gcttcttttt gtagtgagat ttgcagggat
     3241 gctggtcaga gtaacatagc aggtaaagtt gaatttgctg gaaaaatatt tatattagtt
     3301 ttggcaatac caattttaat ggcagtaatg caatctattt tgaaaataat gtagaggtgt
     3361 aggatgagga aatgtaaaat gaataaacga aatatgaaga gacttaatat gaaaaagatt
     3421 ttactgattt tattattttt attatctctg aacattagtg tacaagctgc tgagataggt
     3481 aagatagggg aaaagcagca aactgaaata aataatttat atgactacat ttctaatgtt
     3541 aaatctcaat atgaaatatt taatgatatg cagccacaaa cttttgtaga ggaatttata
     3601 aaaactggtg ataatggttt aagttttaat aaaacatcaa ctttcattat tagatatacg
     3661 tttaaagagg ttattgcatg catggaatta attgggagtc ttatgattat tgctattatt
     3721 tgtgcgatgc taaataatct tcaaagtgct tttaatagag agagtttatc aaatattgct
     3781 taccttgcgt gttatggtgt aatgatttta atgataacca aaagttttta tgtagtagca
     3841 gagcttgcca aaaatacgat tgtcagtatg tctaatttta tgtcagcact tatcccagta
     3901 ctcatgatgc tcctagcaag tgttggtgga tttgcagaag cgacgctgct agaccctgta
     3961 attatgggtt ttgcaacggt aagttctagg atatatgtag atattatcat tcctataata
     4021 tttatgagct ttgtaatgca gtttgtgagc agtatatcta gcgattacaa aataaaaaat
     4081 ctaacaaaac ttttaaaaca aactgccatt tggatacaag gaatagttat gacagtgttt
     4141 attgcggtaa ttacaatacg aagcattgca gcaaagacat tagatcaagt tactataaaa
     4201 acagcaaaat ttgcggtgga tacatttgta cctgtagttg gaaaatgttt atcagatgca
     4261 atttctacag tagctggata ctcacttctt ttaaagagtg ctataagtgg gcttgggtta
     4321 attgttctta tggtaatagt aatacttcct attataaaac ttctgattat ggctttttta
     4381 tataaagcgg cagctgcact aattgaacca ataagcgata atcgcacagt agagtgtata
     4441 aattcagtag gggattctat ttttctttta atgtcttgtg taatatcggt aagtgtaatg
     4501 ttttttataa tggttgcgat agtagcggct actggaaaag gtataatatc aggatgataa
     4561 ttaccatata ttatacttat atggtaaatt tgattctaat cataaaggag gtggtggtaa
     4621 tttgattgaa ctattaaaag tctgggtaac aaatattact atagctatat tttttattac
     4681 tgctgtagag atgattttgc cagacaataa catgaaaaaa tatgcaaaat ttgtattggg
     4741 tttaatgttg attgttataa taataaagcc tataataaaa atctttgata agaactttga
     4801 tttgaattct tattctaata aagcaacaag ttacattgag ggaagtactc agccttcaga
     4861 catgaagaaa tataaagata ttaatatagt aaatacaacg gaaaatttta aaaaaaattt
     4921 acagaaagag tgtattacaa atttagagca gacttatcca gaaaacaaat acaatgctga
     4981 tgtagatgtt gtttatgata gtaaaaatgg agttttcaat attaataggg taaaaattga
     5041 tgttgttgat agcggggttc aaagtattaa aagtataaaa attgatacac aaagtgtgga
     5101 tgcttctaat aacaatattt taacaaacac tctagggaaa cagataaaga agtttttaag
     5161 taataaactt aaaatatctg atgatgttat aactgtttat aaagtaaatt cttaaacaca
     5221 tgattattaa ttgatatata aataagaaaa gagggggatt tctatgaaca atgataattt
     5281 acttagtaaa tttactgagt ttattaaaac aaaaattaat ataggtaatg aaagcagcaa
     5341 aaatgacaaa agcaaaaagt ctgataaact attaggaaat atactattac tgattttggt
     5401 ggcagttgta atagtattag caagcagttc atttaagtcg tcaaagccaa cttcaactga
     5461 acagactaca atagataccg aaacacagaa aaatgcgact gcgaaggtaa ccaacacggc
     5521 tgcagtgaat gattatgaag cacaactaga aagtaaactt aaattaactc ttgaagggat
     5581 tgaaggggtt ggaaaggtac aagtgatgat ctactttgag agtggagagg aaagtgtccc
     5641 tgcagtaaat gttaatgatt ctaaaagtgt tacaaaagaa gatgataaag ccggtggaac
     5701 aagaaatata actcaagata ataatgggag cactgtagtt atggagaata acgggagcgc
     5761 gaatgaaccg ttaattgtaa aaaaaataaa gccaattatt actggcgtat gtgtagtggc
     5821 agaaggatca ggtgtgaaaa ttacagaact taggattaga caggcagtga ttaatttatt
     5881 taatttgcct gagaataaag ttaatgtata tcctatgaat aagtagcata taatttctta
     5941 gaaaggcaga tggggggaaa tattatgaat aaaaaacagt caggtataat tgtaacgttg
     6001 gtagtgctta ttgtgtttgc agggtatctt gcaacgaagg taaatggtcc attgtatgta
     6061 aatgacagtg attttagtaa tgagaaaagt gcaatatctt taaaagacac caaaactgct
     6121 tcaactgctt cgacttattt tgtagaagca aaattatcaa gaaatcaaga caatgataaa
     6181 actcttcaaa ctattaaaac tttaattgat gatactaata ctccaaaaga tcaaaaggca
     6241 actgcatcta agcaatactt aaacatatcg atggcagctc agaaccaatc agacatcgaa
     6301 ctagcattaa aagctcaagg gtttgaagaa tcaatgtgca gtatagttaa tgacaaagta
     6361 caagtagtaa ttaaaactga taaaaaacaa cttacagatg aacagcttcg aagcattaaa
     6421 gatattgtca tgagtaaaac aaaactagaa aaaattgaag ttaagattaa acaataatat
     6481 ttgtaaaaga aatatttatc tgctataata aatatagcat tatcatgttt tacctaagtt
     6541 aaataagggg gtattactat ggaagataaa attttaaatg aaactgaaat gggtgttgtt
     6601 aaaatatctg aggatgtagt tagtgttata gcgggactcg ctgttgctga aatacagggg
     6661 attgttggaa tgagtgcaag tcttgttggt ggaataactc aaatattaag tggaaagaaa
     6721 aatttatcta aaggcgttaa agtcaatgtt ggagaaaata gtgcaataat tgatttacac
     6781 gttgtagttg aatatggtat taaaattcca gaagtaactg aaaaagcaca aataaatgtt
     6841 aaaaaatccg tagagcttat gacaggacta gtagtatcag cagtaaatgt gtatgttcaa
     6901 aatgttgtat tacctaaaac agaaaagctt gaggaaatag aagcatagta ataaacaccc
     6961 tctataaccg gagggtgttt atttatatgt ttgttattct tatgataagg tataatatag
     7021 tatggaaaaa ttaggaggat tactaatgaa tagaagaaag tcgagagaaa cagcaatgaa
     7081 attacttttt gaaatgtcaa taaacaaaga aaaatatgag gatataattg agaattttaa
     7141 agagaacacc gatgttgatt taaatgacct tgatatgtca tatatcacaa aggtgttagc
     7201 tggtattcac gaaaatggta aagatattga taaaaacatt gaaaaatatt taattaaatg
     7261 gaaacttgtt aggttatcaa aaatgaattt ggctatatta agaataagta catatgaaat
     7321 attatatgag gaagaaatac ctaatagggt ttctgtaaat gagggaatag aactagcaaa
     7381 gaaatatggt gaggatagtt ctccagcatt tataaatgga atactcgcga agatgattta
     7441 aaatattata tagtaatagt aataagataa ctagtcagta tactagccta cattgcgact
     7501 tacttaatca atttaacatc tgatagtact aactattagc tgttaaattg gctttgtaat
     7561 gcaagaccta agggtgtata tttgattagt tttttattta taaaaaaaac aattaaaatt
     7621 atgttaaaat attctggtac tagttaatat tttaaaatgt ataaaaggag agaagaatat
     7681 gggaattaga gttaatggta agataatagt tgaaacctac agagatgaga ttaaaaatat
     7741 cataaaagat ggcgttgata gggggcttag agcaccatca attaaaacta tattggtagg
     7801 ctctgatgga ggttctttat catatgtaag aagtcaaaat aacttgtgca ataaattagg
     7861 aatttcctac gcttgtactc aactagagaa agatataagt caaaaggata tcataggtat
     7921 tatagaaaaa ttcaatgagg ataatagcgt agatggaata ataattcaat tacccttacc
     7981 taaaaaccta aatgagaaag aaatcacttc taaaatttca tataaaaagg atattgatgg
     8041 attaacagat gtaaatatgg gtagatttta taagggagat aaaagcttta ttccttgtac
     8101 tgcattaggg gttattgaaa tgattaaaaa tacgggatgt aatattaaag gcaaacatgc
     8161 agttgttatt ggtagaagca atattgttgg aaaaccggta gctcaattgt tattaaatga
     8221 agatgcgacc gtaacaatat gtcattcaaa aacaacgaat ttgaaagaag tttgtaaaac
     8281 ggcagatata atagttgcgg ctattggtaa accaggcttt gtgacaagtg aatttattaa
     8341 ggcgggagca attgttatag atgttggaac tacaatgata gataataaaa ttactgggga
     8401 tgtaaatttt gacgatgtta ttaatcacgc aagttttgtt agtccagttc caggtggaac
     8461 gggactaatg actacaacga tgctaataaa aaatgcttgc gcttcgtgga gggataatgt
     8521 ttattaaagt aataacagta actgccctta atgggtatat taaaaaagta atagatagtg
     8581 attttatatt aaataatgct aatgttaaag gagaattgtc taatgtaaaa ctacatagta
     8641 gtggacatat atacttctca ttaaaagacg aatttggaaa agtaaattgt gtaatgttta
     8701 aatcgcaggc tcaaaagctt gttattatac ctagggatgg tatgaatgtt ataattagag
     8761 ggcgagtttc ggtttatgaa aagggtggtg catatcaagt ttattgtgac tctatggaga
     8821 cggatggaga agggcaatta tttttagctt ttcaaaattt aaaagagaaa ttacagaaat
     8881 tagggttgtt tgatgaagaa cacaaaaaaa tcataccatc atttcctagg agaataggta
     8941 tagttacatc acaaacaggt gctgctgtta aagatattat taatgttgca acaaggcgta
     9001 atgctaatgt taatatgtta atatatccga ctcttgttca aggagtaagt gctagttctg
     9061 aaattgaaca aggtataaaa tatttcaata actcgaaaaa tgttgattta attattattg
     9121 caagaggagg aggctcaatc gaggaactat gggcattcaa tgaagaaaat ttagcttatg
     9181 caatatataa ttctaagatc cctataatta ctggtattgg tcatgaaact gattttacta
     9241 tagcagattt tgtttgtgac catagagctc caactccatc ctccgctgca gaaatagcag
     9301 tgagaaattt aaaagattta aataatgaaa ttaaatcact tagagaactt ttgttaagat
     9361 ctgtggaatt taagtttact aaagaatata ataaaattaa tttactaagt aaaactttga
     9421 aagtaaataa tccattgaat tttatagtta gccaatatac gcatatagat aacttaagag
     9481 aaaatttaaa ttataaattt aatgcaaaaa tttcaatgga aaagcagaaa ctttcaaagt
     9541 tgaatgctct aatgaacgca cataatcctt taaatgtatt aaacaggggg tatgcagtac
     9601 ttcaaaatga tgagaatgag gttattagtg aaattagtat tttaagaaat attaaagatg
     9661 taaagattat attaaaggat ggcactgcta gatttaatat aagcaatttg gaggagttat
     9721 aatggcaaag aaaaaagaat cttatgaaac gatgatggaa aggcttgaaa aaattgtaga
     9781 agtgatggat tcaaatgaaa taacactaga agggacaatg gtaaattatg aggaaggcgt
     9841 caagatatgc aacaacttgt ataaaattct caatgacaca gaaggtaaaa taaaaatatt
     9901 aactgatgag ggcgaaaaag attttacgcc tcatgtggaa tagattaaga attaagtatc
     9961 cgaaggtgaa ttaataatta taatggaaag aagggataaa atgaatatac aattgcttag
    10021 agagtctgta gaaaaatgga tagatgatta ttttaaaggt aagtctaaaa agaatagtaa
    10081 aaactttgag gcaatgagtt acagtataaa agtcggagga aaaagagtta gaccaatttt
    10141 aatgcttctt acatatggta tgtataagga agattataga gatatattac cttttgctgc
    10201 agcccttgaa atgattcata catactcact tattcatgat gatttgcctt gtatggataa
    10261 tgatgattta cgtcgtggaa aacctacaaa tcataaagtt tatggagagg cgattgcggt
    10321 cctagcaggg gatgggttat taaatgaggc tatggtaata atgctagatc aatgtttaga
    10381 tggggattta aacacaatta aggcaagtaa tattatagca aaagcttctg gggcagaggg
    10441 tatgatagct gggcaaattt gtgatatctt aagtgaagga atgaaaatat cagaagaaaa
    10501 attactgtat atgcataaaa acaaaacggg ggaactaata aaagcggcgg tagtatgtgg
    10561 tgcgaccctt ggaaatgctg atgagactga tttatgttat ttaaaagagt atggtgataa
    10621 attaggttta gcatttcaaa taaaggatga tatattagat gtaattggcg atgttgctat
    10681 tctaggaaag aatacaaaaa gcgatgaatt taataataaa actactttta taacaatgta
    10741 tggtttagaa aaatgcaagc aaaagtgtaa tgatttaact caggagtgtt ttaagatatt
    10801 aaatcaaatt aaggtgaata ctaaatattt agaagaaatt acggaatctt tattgaaaag
    10861 ggaatattaa aaataaaaca actatttata attattaagt atcttttgga tgtcattaaa
    10921 tgggttttat agtcgaaata gcttttgaat taaataatat tatatgatat aatatttcca
    10981 taaatgtggg tgaaataata tattttataa aagaggatag ataatgagta aaatactaga
    11041 taattttaat gatataaatg atataaaaaa aatgactata caagagttga atgactttgc
    11101 aaaggaaatt agacactttt tagttgaaaa agtctctaaa acgggaggac atctagcttc
    11161 taatttgggc gtagtggaat taacattaag cttatataat gtttttgatt tggataaaga
    11221 taaattaata tgggatgtag gacatcaatc atatgtacat aaaattctta cgggaagaaa
    11281 agataaattt gatctactta gaaattatgg tggattaagt ggctttccga aaagagaaga
    11341 aagtaaatat gatgtatttg aagcgggaca tagtagtact tctatttcag taggggctgg
    11401 cattgcaagg gctcgtgatt tacaaaaggg agactataat gttatttcag ttataggtga
    11461 tggggctctt acgggtggta tgtcttttga ggcattaaac gatataggat ttagaaaaac
    11521 taaaatgatt attgtgctaa atgataacca aatgtctatt tctaaaaatg tgggaggcat
    11581 gtccaaatat ctaagtcaat ttaggattga cccaacttat aatagaatta aaaaagaaat
    11641 aaattctacg cttagaaaga tacctaatgt aggtgatgga atgattaatt caattcaaaa
    11701 aataaaaaac ggaattaaac aggtagtggt tccgggaatg ttatttgaaa atatgggtat
    11761 aacttattta ggacccatag atggacatga tattaaagag gtaagtaagg tcttaaaact
    11821 tgcaaaaaaa acagatggac ctgtgattat ccatgtaata actaaaaaag gcaagggtta
    11881 taaatttgct gaagagcagc caaataaatt tcatggtgta gggccattta atccatcaaa
    11941 tggagaatta tgtagtagtc acaaggaaag ttattctgag gcatttgggg agcagattgt
    12001 aactctagca aagaaaaaca aaaatatagt agcaataacg gcggcaatgc ctgaaggcac
    12061 aggattagaa tcgttttcaa aagaatttaa caataggttt ttcgatgtgg ggattgcaga
    12121 gcaacatgca gttactatgg ctgcaggaat ggcttcacaa ggacttaaac cgatttttgc
    12181 agtttattct acatttttgc agcgagcgta tgaccaaatt ttacatgatg tatgtattca
    12241 aaatttacct gttatttttg caatcgatag ggcaggcatt gttggacaag atggggaaac
    12301 gcatcaagga atatttgatt tatcatattt atcgcatatt ccaaatatga caatcatggc
    12361 tcctaaatgt ataggagaac ttaaaacaat gcttacgttt gcagttaaac aagattatcc
    12421 aattgctata agatacccta gaggtggaga taatccaaat gttaaaatgt ctcctattaa
    12481 tgacttacag cggggaaaat gggagactct gcttgccggt ggtaaaatag catttatagc
    12541 tacaggtaaa atggtacaaa atgcaatatt agttagagaa aaattattga atatgggaat
    12601 agagtctact gtagttaatg catgttttat taaacctatt gataaaaaat tactgttaga
    12661 tcttgtagat aaaaaatatt ctttagttac tattgaagat aatgtagttc atggtggatt
    12721 aggttcttta gtattagaat atgtgaattc attgaacaag aacacgaagg taattaattt
    12781 aggatttaat gatgaattta ttccacatgg gtcagttgat atactgtata agttatataa
    12841 actagatgtg gatggaattt ttgatagtat tttgaaatta gtctgaaatg tactttagta
    12901 gggattaagg agttttttat gatagaaaat aaagagagat tagatgttat tgtggttgag
    12961 agaggcattt tgttttcaag agaaagagca aaggaaaata ttattgctgg aaatatattt
    13021 gtcgatggta ttaggactac taaatgtgga aaaaaaattg atgttacatc tagtatcgag
    13081 ttcattggta aagacatccc ttatgttagt agggggggcc ttaaacttaa aaaggctata
    13141 gatgccttta agattgatct taaggataaa gtttgcctgg atataggcgc atctacagga
    13201 gggtttacag actgcatgct acaacatggg gcatgcaggg tatactcgat agatgttgga
    13261 ataaatcagc tagatgataa gttgagaggt gactctcgag tagtttctat ggagaaaaca
    13321 aacatcagat atttaaataa agacagcatt tgcgaacttg cagattttgc aagtattgat
    13381 gtatcattta tatcgcttga aaaagttatc cctaatttat taaatctatt gaaaaatgat
    13441 ggtagtgttg tggcattact taagccacaa tttgaagtag gtataggtgt agtaaataaa
    13501 aaaggtgtgg ttaaaaaacc tagtgaccat atcgatgtaa tagttggagt actaaatcta
    13561 cttaaaagcc ttaatgtaaa ggttattaat gttgattatt catcaataaa agggcctaat
    13621 ggaaatattg agtatttagt ttattttact aaatctaaaa atggttatga tgattatgtt
    13681 gaagataatg tagctttatt agttagtgat gctcatagaa gtttaaattg tctcaaacgg
    13741 gaataattta tagtgtgtgg tacaaaatgg taaggaggaa atatgaaaaa cattggcatt
    13801 aatataaata ccactaaaga taaggatggg aaaatcggta aatatgtaaa agatattatt
    13861 agccaatata ttgatgatac taatatattt gtgtttaaag attccattgg acttgaagat
    13921 attaaatata actatttgga tattattgtt gctttaggtg gagatgggac tattttaaga
    13981 acatctcgta atttaaataa ctccaatatt ccaatactag gagtgaatat tggaaattta
    14041 ggatttctct ctagtgtgga actactagaa tttgaaagtg ctatgaaaag atttattaat
    14101 gatgattatt atgtagaaga gagaatgatg cttaattgta ctttgccaaa taggaatgaa
    14161 cttgaaaaat atacggcact taatgatatt gttgtatcaa agggaacact tgcgagagtt
    14221 gttaaatatg aacttcatat agataataag ttttacatcg attttacagg ggatgggctt
    14281 ataatagcta caccaacagg atctacagca tactctctat cagcaggagg gcctataata
    14341 tatcctaacc tagatgttat agaggtaaca cctatttgtc cattatcgtt atctatgaga
    14401 actatagtgc tagatagtaa aagtgaaata tctgtaaata taaaatgtga acatgaaagc
    14461 atatttttga cattagatgg tcaaagagca ataaaactaa atagctatga gaaaatactg
    14521 gtaagtgttt cagagcaaaa atgtagatta gttaaattta atgattataa ttattttggt
    14581 attttgagga agaaaataat ttctagaaca acagattgtg agggagaaaa agatgaagat
    14641 atcgcgtcat gcaaaaataa ttgagatcat tcagtctaaa gatgttgaaa ctcaagaaca
    14701 gttagcacag gaattaaaaa ataatgggtt tgatattact caggcaactg tttctagaga
    14761 tataaaagaa ctaaaattaa ttaaggttat gaatgcacat ggaactcaca tatattcgac
    14821 tagttctcca ggtgatagtt ttttatcaaa taaattggtt aatatttttt ctcaaaccgt
    14881 tttgtatgtt gataatgtag ataaatttat agtacttaag acaatatcag gagctggtgc
    14941 tgccgcagct gaagccttag attctttgaa attcagtggg attgtaggga cggtagctgg
    15001 agataacact gtttttattt tagttagaaa tgaagaagat tctaaagata taattcaaaa
    15061 ggttaaaaaa atgattagtg aataggagga attagtatgc tcctacaatt aaatattatg
    15121 aattttgccc taattgaaaa attaagcatt aattttgaaa gaggttttaa tgttctttca
    15181 ggtgaaactg gagcaggaaa atcaatttta attgatgcta taaattatgt attagggggt
    15241 aaatttaata agagcttaat tagaacaggg gaaaataaaa cttatgtaga ggctattttt
    15301 accatagata accaaaataa taggaatgtt ttagaagaga tggatattga ttatgaggat
    15361 acagtattca taagtcgtga aacttttcaa tcaggaaaaa gtattgctaa agttaatggt
    15421 aaatcattgc tactcgcaaa agttaaatat attagtaaaa atctactaga tattcatggt
    15481 caacatgata accataactt attagataaa gctaatcata tattttatgt ggattctttt
    15541 ggtaatgaga ggcttggaac ggctataatt gaatataatg acaaatacac aagaatgact
    15601 agtataaaaa atagaattct taaacttgaa ggtaatgaag gagaacgaga taagagaatt
    15661 gattttttaa attatcagtt agaagagatt aaaaatgcta atctcaaaat tggtgaagat
    15721 gaggaacttt tagaaaaata tgcaatagtt agtaattctg aaaacttgga gaagcattta
    15781 tcaataagtt atcaattatt atacactagt gatgaggaaa atccttcagt attgtataat
    15841 ttagctattg ccataaaaga acttcgaact attgaaaaac atatggataa aataaaagta
    15901 attacagatt ctattgagga aagttatttt aatattgagg aaaatatcac agaaatcaga
    15961 gacttaaaag agtcaattta ttatgatgaa aaagaattgg aatatatgaa tagtagaata
    16021 agccaaatta ataattgtaa gaagaagtat ggatctacta taaaagaaat ttatgaatat
    16081 agagataaaa ttgatgttga gtatgaagaa ttaactaata gtagtgaaat aatcacttct
    16141 cttaaaaaag aaaaaatagc tcttgagggt gaaatgagaa ttatagcaga tgaaatccat
    16201 gaaattagat gtgagacagc aaaaaatctt caaagtaaaa taaaagatga gcttaattat
    16261 attggacttg aaaggagtaa attttttatt gaagtaaaac ttacagatga attttataaa
    16321 aatggttgtg ataaagttca attttgtata gctaccaacc caggtgaacc attaaatcct
    16381 ttagaagaaa tagtatctgg aggagaatta tcacgtatta tgcttgcact taaaactgta
    16441 ttcgtggata aggatgaaat accaactgtt atatttgatg aaatagatac cggcattagt
    16501 ggcaggattg cgcaatgtgt tgcagagaaa atgtatctaa tatcattaaa ccatcaaatt
    16561 ttttgtgtaa ctcatttgcc acaaatagct agtatggcag atataaatta tctaatatcc
    16621 aaaaatgtta taaatgataa aacatatact aatattatac gaatgaatga taatgaaaag
    16681 caacaagaaa tagctagaat gataggtggc acagaggtta ctaaattaac attagaaaat
    16741 tctaaggaaa tgataaattt ggctaatgat cgaaagaaaa aatagttttg atttttataa
    16801 gaataaagta ataaatattt atttaatagg gaaaaataaa gtcattaaat atgactttat
    16861 ttttttgctt ttaaagttag tggaattata aactttctta tgaagtcgtt aatatttcag
    16921 ctccgcagga gatgatttaa tgatttataa aattctaaat gtgggtaaca ttataatcaa
    16981 atttaatgaa atagttcaat gttgtattat ttataaaata attgaaatac agaagaattt
    17041 ttttaattta tcataattta gttttgaatc tatgtctttg actatttttg aattaatatt
    17101 atagcataat atgagattgt gagggtaact taaatttata actataagag aaaaggagat
    17161 aaagcttatg aaaaaaagat tgaatatatt ttgcttactt ataacaccga tactaataat
    17221 tgctttaggt gtttgctacc aaagtcaaag tatagctgtt tctgcatttg acaaacaaat
    17281 acaaacttta tattctaaca acattataaa tgcaaaagta aatacaaata atgttctttc
    17341 aaatcattat ataattgaaa aaggcaaaaa agttaaagaa gatacagata atgtgttaaa
    17401 agcaaaatta acttttgtaa cgaaaaataa agatataatg gtttatccag gagggcaacc
    17461 aattggtgtt aaactaaata ctaagggagt tttagtagtg gctttatctg atattgatgg
    17521 tgttaatggt aaaacacaaa gtcctgcttc aaatgccggt gtagaaatag gagatagtat
    17581 aataaaaata aataatattg ttataaatca cgccgaagat ataagtagat ttgttaacaa
    17641 agaaaaaaat ccggagctta cacttaaaat acagcgtaga aatggttcaa agatttttga
    17701 tataaaggtt aaacctacta ttgattccac agatggtaaa caaaaaattg ggttatgggt
    17761 aagagattct actgcgggcg ttgggacgtt aacattgtat gatagtagaa ctaacaaatt
    17821 tgcagcgcta ggtcacccga ttacagattc tgatactgga acaatattaa gtattaataa
    17881 tggtgtaata atatcttcta atatagtttc tataaaaaaa ggtactagag gaacgccggg
    17941 agagttaaga ggccttttta tagatgaaaa caaaataaaa ggtcaattaa taaataatac
    18001 acaatgtggt atatttggaa atggaagtga aagtcttata aacaataaat ttaataaacc
    18061 tatgaaaata ggtcttagaa atgagataaa agaaggcgaa gcgcaaattt taactactat
    18121 taatggtaat gagccggaat tatttaaaat agaaattcaa aaactattat cacaagatat
    18181 accaggctca aaaagcatga taattaaaat tacagatcct agacttttag agaaaacagg
    18241 aggcatagtg caaggtatga gtggtagtcc aataattcaa aacaataaaa ttgttggagc
    18301 ggttacccat gttttaatta ataaacctga cgttggatat ggtatataca ttgaatggat
    18361 gttgaaagat gcaggcattt tatcaaaata actagcatta tctaaaaaaa agaggtaaaa
    18421 tagatataat gagatataga gtagcatatg ttatcctata cattacaaat aaatgataat
    18481 ttatcattta tttgtaatat tttttttaat ataagaagga attgtaattc ttttgtcgaa
    18541 ttaatatttg ttaagatatg ggaatttatt tataaagggg agttagaata tggaagaacc
    18601 aagaattagt gtgcttattg cagatgataa taaagagttt tgtaatattt taaatgatta
    18661 tttgctaagc caaagagata ttatggttac aggtattgca aaagatggaa tagaggctct
    18721 taagctaata aaagagagaa aacctgatct agtagtattg gatataataa tgccacattt
    18781 agatggtctt ggcgtccttg aaagattagg cagtatggat cttaatccaa tacctaaaat
    18841 aatagtttta tctgcagtgg gacaagataa aataacacaa agggctatag cacttggagc
    18901 agattattat gtagtaaaac catttgatat ggaagttttc acaaaaagaa taaggcagat
    18961 gtttaacaat acgatttcta gtgataacag tagtaaaaaa tcaatttcgt ttattgatac
    19021 aactgaaact aggaaaagca accgtaatga acctatggac ttagaagctg aaataacaaa
    19081 tataatacat gaaattggag tgccagctca tattaaggga tatatgtatt taagagaagc
    19141 aattactatg gtagtaaatg atattgaact tttatctgca gtgacaaagg aattataccc
    19201 atctattgct aaaaagttta atactactgc tagtagggtg gagagagcaa taagacatgc
    19261 tatagaagta gcatggggac gtggtcaagt tgaaaccata aacaaaatat ttggttatac
    19321 cgttcataat gctaaaggta aaccaactaa ttcagaattt atagcgatgg ttgctgataa
    19381 gttaaggtta caaaataggg ttagctaaat ggatagatta agagtgtctt taatagatgc
    19441 tcttttattt tgtttaatag gaaggcttaa gaaaaataat aggatgtaag caaaagctta
    19501 catccttaat attaattaga attatagtta ttaagatatt cttcaaaaga atcgtaaatc
    19561 aaattatcat tagaaattga atcttcctta gaattaagtt tagtagttaa atttttattt
    19621 ggtagttttt ctattttttt agtattgata ttgatattga atcacctcta tacaagtatt
    19681 ataacacaaa atatgtaatc cgtaaaggtg gtttcctttt tatagttaaa tttatggaga
    19741 agaggtgaat taattcaaca tacgaaccac ttatagaagt gggcgattgt aaaccgcaaa
    19801 agcggtccag ttctcattga actaagaacc gtaagaaact gtttaattca acattagaag
    19861 atttattcca tttagcttcg caagcagcat agtttgtata ataagtatta agattaaaca
    19921 tatttttaat agttaaatga atactctgag aaagattttt ctcatgattg taaacaagaa
    19981 ttgaataagc tttaatttta gcttcattac caatatacag tatatttgat aggttattaa
    20041 aatttccgct actaagctta tctttatata tccttgtaga agaattagtt tctatcctca
    20101 aaatattcgc cacctttttt ataatctcta atatatatta tgccgtaata gagcctataa
    20161 tattaaggta tataaaaata attttgcaaa taaagataaa attgtaatgt ggttattaat
    20221 gttgaactaa atatgcatat aaactccttt gttatcataa atattaatta agatattgta
    20281 attatttatg ctcaatttca tcttaaataa ggtgaagccc agcatgaata taacgtgagt
    20341 ggattttaat aacatattat gagcagctat aaaaaaatat aatgattaac aaagggggaa
    20401 aaattatgtc atctaacgca ttggtaagta atgtaaataa acatatacaa gagaattatt
    20461 ggttgtatat tataagtatc ttgtgtgtat ttacaggtat aattttaggg atttatagtg
    20521 tgaagtatat gggtgaattt gaacacaagg atttagtgaa ttatttagtt aattttattg
    20581 atccttcaaa cacaagtggg attagttata aattaatatt ttttcaatca ataaaaaata
    20641 atttaccagt aattattttt ctatggtttt tagggttaac tattgtgggt ttaccaatta
    20701 ttgtgatcat tgatttgtta aaaggattta cagttgggtt tacatttagt tttatgatta
    20761 gtgggctagg aaagagtggt attggtattg caatgctagg ggtattacct caaaatttaa
    20821 tttatattcc atgcactatt tttgcatcgg tgatatcaat ggaattttct
//
