Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
2.1
3.1
5.1
5.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP086140.1 (Clostridium estertheticum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 943,121 | 955,343 |
Region 1.2 | terpene-precursor | 1,953,804 | 1,974,673 |
Region 1.3 | ranthipeptide | 2,348,255 | 2,369,818 |
Region 1.4 | NRPS,NRPS-like,T1PKS,cyclic-lactone-autoinducer | 2,494,258 | 2,550,410 |  |
Region 1.5 | deazapurine | 3,692,944 | 3,715,342 |
Region 1.6 | cyclic-lactone-autoinducer | 3,867,343 | 3,889,442 |
Region 1.7 | cyclic-lactone-autoinducer | 3,941,480 | 3,962,273 |
Region 1.8 | darobactin,triceptide | 4,024,990 | 4,046,042 |
Region 1.9 | terpene-precursor | 4,409,339 | 4,430,169 |
Region 1.10 | transAT-PKS,NRPS,cyclic-lactone-autoinducer | 4,662,389 | 4,752,902 | Low | estericin A | ribosomal:RiPP

NZ_CP086142.1 (Clostridium estertheticum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | cyclic-lactone-autoinducer,lanthipeptide-class-ii | 17,251 | 45,192 |

NZ_CP086145.1 (Clostridium estertheticum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | lanthipeptide-class-ii | 1 | 16,351 |

NZ_CP086141.1 (Clostridium estertheticum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | cyclic-lactone-autoinducer | 264,922 | 15,917 |
Region 5.2 | lanthipeptide-class-i,lanthipeptide-class-ii | 150,029 | 194,775 | Low | cesin A | ribosomal:RiPP

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 943,121 | 955,343 |
Region 1.2 | terpene-precursor | 1,953,804 | 1,974,673 |
Region 1.3 | ranthipeptide | 2,348,255 | 2,369,818 |
Region 1.4 | NRPS,NRPS-like,T1PKS,cyclic-lactone-autoinducer | 2,494,258 | 2,550,410 |  |
Region 1.5 | deazapurine | 3,692,944 | 3,715,342 |
Region 1.6 | cyclic-lactone-autoinducer | 3,867,343 | 3,889,442 |
Region 1.7 | cyclic-lactone-autoinducer | 3,941,480 | 3,962,273 |
Region 1.8 | darobactin,triceptide | 4,024,990 | 4,046,042 |
Region 1.9 | terpene-precursor | 4,409,339 | 4,430,169 |
Region 1.10 | transAT-PKS,NRPS,cyclic-lactone-autoinducer | 4,662,389 | 4,752,902 | Low | estericin A | ribosomal:RiPP
Region 2.1 | cyclic-lactone-autoinducer,lanthipeptide-class-ii | 17,251 | 45,192 |
Region 3.1 | lanthipeptide-class-ii | 1 | 16,351 |
Region 5.1 | cyclic-lactone-autoinducer | 264,922 | 15,917 |
Region 5.2 | lanthipeptide-class-i,lanthipeptide-class-ii | 150,029 | 194,775 | Low | cesin A | ribosomal:RiPP

No secondary metabolite regions were found in these records:
  NZ_CP086144.1 (Clostridium estertheticum)
  NZ_CP086143.1 (Clostridium estertheticum)

Compact view
NZ_CP086140.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 943,121 - 955,343 nt. (total: 12,223 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0002005.2 |  | 0.50 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002698.2 |  | 0.44 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.43 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000589.5 |  | 0.41 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0002005.2 |  | 0.50 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002698.2 |  | 0.44 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.43 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000589.5 |  | 0.41 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.61 out of 18.16
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.56 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.68 out of 24.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.37 out of 24.78
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response

NZ_CP086140.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,953,804 - 1,974,673 nt. (total: 20,870 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthase synthetase
LL065_RS09435: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

LL065_RS09440: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0001361.3 |  | 0.45 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.45 | terpene | sodorifen | Serratia plymuthica
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.3 |  | 0.36 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0001594.3 |  | 0.35 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.35 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0001361.3 |  | 0.45 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.45 | terpene | sodorifen | Serratia plymuthica
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.3 |  | 0.36 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0001594.3 |  | 0.35 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.35 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
LL065_RS09435: PT_FPPS_like
Domain 1 (29 - 288): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.89 out of 23.79
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.45 out of 27.55
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.39 out of 27.55
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.69 out of 32.93
Confidence: medium
Additional weak hits (3):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.31 out of 39.62
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.31 out of 39.62
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.10 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
LexA variant 3 | Repressor of DNA damage response

NZ_CP086140.1 - Region 3 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,348,255 - 2,369,818 nt. (total: 21,564 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
LL065_RS11315: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000599.5 |  | 0.40 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001387.5 |  | 0.33 | other (other) | nucleocidin | Streptomyces calvus
BGC0001860.4 |  | 0.32 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.4 |  | 0.30 | ribosomal | GE2270A | Nonomuraea sp. WU8817
BGC0001155.5 |  | 0.30 | ribosomal | GE2270 | Planobispora rosea
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001591.4 |  | 0.29 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000027.4 |  | 0.27 | PKS | ankaflavin, monascin, rubropunctatine, monascorubrin | Monascus pilosus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000599.5 |  | 0.40 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001387.5 |  | 0.33 | other (other) | nucleocidin | Streptomyces calvus
BGC0001860.4 |  | 0.32 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.4 |  | 0.30 | ribosomal | GE2270A | Nonomuraea sp. WU8817
BGC0001155.5 |  | 0.30 | ribosomal | GE2270 | Planobispora rosea
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001591.4 |  | 0.29 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000027.4 |  | 0.27 | PKS | ankaflavin, monascin, rubropunctatine, monascorubrin | Monascus pilosus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (2):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 17.97 out of 23.43
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (2348254...2369818)
LL065_RS11280
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 1 - 100
  Score: 89.3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP086140.1 - Region 4 - NRPS,NRPS-like,T1PKS,cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,494,258 - 2,550,410 nt. (total: 56,153 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase carboxylase transferase
LL065_RS12115: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

LL065_RS12140: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

LL065_RS12145: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

LL065_RS12150: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: esterase
LL065_RS12120: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: lyase
LL065_RS12175: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase
LL065_RS12095: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LL065_RS12105: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | T1PKS | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001240.4 |  |  |  |  | 1.17 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001261.3 |  |  |  |  | 1.17 | NRPS | AM-toxin | Alternaria alternata
BGC0001276.3 |  |  |  |  | 0.96 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0002192.3 |  |  |  |  | 0.90 | PKS | FR901512 | fungal sp. No.14919
BGC0001258.3 |  |  |  |  | 0.88 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0001257.3 |  |  |  |  | 0.88 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0002154.2 |  |  |  |  | 0.88 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0002175.3 |  |  |  |  | 0.88 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0000107.3 |  |  |  |  | 0.87 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001284.4 |  |  |  |  | 0.85 | PKS | alternariol | Parastagonospora nodorum SN15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001276.3 |  | 0.66 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0002192.3 |  | 0.64 | PKS | FR901512 | fungal sp. No.14919
BGC0001258.3 |  | 0.63 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0001257.3 |  | 0.63 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0002154.2 |  | 0.63 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0001240.4 |  | 0.63 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002175.3 |  | 0.63 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0001261.3 |  | 0.63 | NRPS | AM-toxin | Alternaria alternata
BGC0000107.3 |  | 0.63 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001284.4 |  | 0.62 | PKS | alternariol | Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.85 out of 24.78
Confidence: medium
Additional weak hits (1):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.95 out of 39.62
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 2494257 - 2550410:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 2494257 - 2539969:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 2501197 - 2550410:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LL065_RS12095: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (668..1092): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWHTFDISVWEWHFIFSGEANLYGPTEASIDVTC
  Nearest Stachelhaus code(s):
    Ser DVWHISLIDK (82% 8Å match)
  Stachelhaus code match:
    90% (moderate)

LL065_RS12105: fatty_acid - mal
CAL_domain (186..499): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 77.0
  NH2: 24.8
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

PKS_AT (1258..1539): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 79.2%
  Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 120.2
  inactive: 109.5
  Methylmalonyl-CoA: 50.9
  Methoxymalonyl-CoA: 50.4
  Propionyl-CoA: 35.8
  Isobutyryl-CoA: 22.8
  Benzoyl-CoA: 19.3
  2-Methylbutyryl-CoA: 15.4
  Ethylmalonyl-CoA: 13.0
  fatty_acid: 11.2
  trans-1,2-CPDA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response

NZ_CP086140.1 - Region 5 - deazapurine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,692,944 - 3,715,342 nt. (total: 22,399 nt) Show pHMM detection rules used
deazapurine: (GTP_cyclohydroI and PTPS and QueE and QueC and not (dpdA1 or bTGT))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase kinase
LL065_RS17455: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

LL065_RS17460: acetylglutamate kinase

smcogs
  SMCOG1174: acetylglutamate kinase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | deazapurine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001217.5 |  | 0.52 | other (other) | PreQ0 Base | Streptomyces qinglanensis
BGC0000852.5 |  | 0.48 | other (other) | ectoine | Sporosarcina pasteurii
BGC0002354.4 |  | 0.48 | other (other) | huimycin | Kutzneria albida DSM 43870
BGC0000859.3 |  | 0.47 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000855.3 |  | 0.47 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000856.3 |  | 0.47 | other (other) | ectoine | Methylophaga thalassica
BGC0000858.3 |  | 0.47 | other (other) | ectoine | Methylobacter marinus
BGC0000881.3 |  | 0.47 | other (other) | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5 |  | 0.47 | other (other) | toyocamycin | Streptomyces diastatochromogenes
BGC0000853.3 |  | 0.45 | other (other) | ectoine | Streptomyces anulatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001217.5 |  | 0.52 | other (other) | PreQ0 Base | Streptomyces qinglanensis
BGC0000852.5 |  | 0.48 | other (other) | ectoine | Sporosarcina pasteurii
BGC0002354.4 |  | 0.48 | other (other) | huimycin | Kutzneria albida DSM 43870
BGC0000859.3 |  | 0.47 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000855.3 |  | 0.47 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000856.3 |  | 0.47 | other (other) | ectoine | Methylophaga thalassica
BGC0000858.3 |  | 0.47 | other (other) | ectoine | Methylobacter marinus
BGC0000881.3 |  | 0.47 | other (other) | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5 |  | 0.47 | other (other) | toyocamycin | Streptomyces diastatochromogenes
BGC0000853.3 |  | 0.45 | other (other) | ectoine | Streptomyces anulatus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.28 out of 20.01
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97
Confidence: medium
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.67 out of 30.11
Confidence: medium
Additional weak hits (5):
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.13 out of 19.52
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 30.11
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.44 out of 30.11
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CcpA | Catabolite control protein A
CelR | Cellobiose uptake repressor

NZ_CP086140.1 - Region 6 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,867,343 - 3,889,442 nt. (total: 22,100 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
LL065_RS18295: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000552.3 |  | 0.40 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000528.5 |  | 0.39 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000497.3 |  | 0.37 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0002110.3 |  | 0.37 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0001788.3 |  | 0.35 | ribosomal | suicin 65 | Streptococcus suis
BGC0000544.4 |  | 0.35 | ribosomal | planosporicin | Planomonospora alba
BGC0000548.4 |  | 0.34 | ribosomal | salivaricin A | Streptococcus salivarius
BGC0002496.3 |  | 0.33 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000552.3 |  | 0.40 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000528.5 |  | 0.39 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000497.3 |  | 0.37 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0002110.3 |  | 0.37 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0001788.3 |  | 0.35 | ribosomal | suicin 65 | Streptococcus suis
BGC0000544.4 |  | 0.35 | ribosomal | planosporicin | Planomonospora alba
BGC0000548.4 |  | 0.34 | ribosomal | salivaricin A | Streptococcus salivarius
BGC0002496.3 |  | 0.33 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.94 out of 29.25
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.71 out of 28.19
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.81 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.43 out of 18.16
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.06 out of 18.46
Confidence: medium
Additional weak hits (2):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.72 out of 25.88
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CatR | H2O2-responsive repressor
CcpA | Catabolite control protein A
RpoN | Regulator of nitrogen assimilation and virulence
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_CP086140.1 - Region 7 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,941,480 - 3,962,273 nt. (total: 20,794 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase
LL065_RS18645: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: cyclase
LL065_RS18590: diguanylate cyclase

smcogs
  SMCOG1025: diguanylate cyclase

LL065_RS18620: diguanylate cyclase

smcogs
  SMCOG1025: diguanylate cyclase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002328.3 |  | 0.53 | ribosomal | Rc-AIP1 | Ruminiclostridium cellulolyticum H10
BGC0002482.2 |  | 0.33 | other (other) | tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M | Symphyonema bifilamentata 97.28
BGC0001650.4 |  | 0.31 | NRPS | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0002387.2 |  | 0.31 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0001148.5 |  | 0.30 | NRPS, ribosomal | pheganomycin | Streptomyces cirratus
BGC0000221.5 |  | 0.29 | PKS | erdacin | uncultured soil bacterium V167
BGC0002545.3 |  | 0.28 | PKS | sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G | Micromonospora sp.
BGC0001066.5 |  | 0.25 | PKS | kendomycin | Streptomyces violaceoruber
BGC0001060.5 |  | 0.24 | PKS | dynemicin A | Micromonospora chersina
BGC0002087.3 |  | 0.23 | NRPS, PKS | gladiostatin A | Burkholderia gladioli 238

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002328.3 |  | 0.53 | ribosomal | Rc-AIP1 | Ruminiclostridium cellulolyticum H10
BGC0002482.2 |  | 0.33 | other (other) | tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M | Symphyonema bifilamentata 97.28
BGC0001650.4 |  | 0.31 | NRPS | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0002387.2 |  | 0.31 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0001148.5 |  | 0.30 | NRPS, ribosomal | pheganomycin | Streptomyces cirratus
BGC0000221.5 |  | 0.29 | PKS | erdacin | uncultured soil bacterium V167
BGC0002545.3 |  | 0.28 | PKS | sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G | Micromonospora sp.
BGC0001066.5 |  | 0.25 | PKS | kendomycin | Streptomyces violaceoruber
BGC0001060.5 |  | 0.24 | PKS | dynemicin A | Micromonospora chersina
BGC0002087.3 |  | 0.23 | NRPS, PKS | gladiostatin A | Burkholderia gladioli 238

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.04 out of 29.38
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.85 out of 28.14
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.23 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (3):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.85 out of 39.62
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.35 out of 30.22
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.41 out of 27.18
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP086140.1 - Region 8 - darobactin,triceptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,024,990 - 4,046,042 nt. (total: 21,053 nt) Show pHMM detection rules used
darobactin: ((cds(PF04055 and (TIGR04085 or SPASM)) and darobactin_precursor) or darobactin_rSAM)
triceptide: ((cds(PF04055 and (TIGR04085 or SPASM)) and triceptide_precursor) or triceptide_rSAM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LL065_RS19040: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | darobactin | triceptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000600.3 |  |  | 0.26 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0001210.5 |  |  | 0.24 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002049.3 |  |  | 0.24 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0002447.3 |  |  | 0.24 | ribosomal | cerecyclin | Bacillus cereus
BGC0000487.5 |  |  | 0.23 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0001576.3 |  |  | 0.23 | ribosomal | divamide A | Prochloron didemni
BGC0000523.3 |  |  | 0.23 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000520.5 |  |  | 0.21 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0002663.2 |  |  | 0.20 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002442.3 |  |  | 0.19 | ribosomal | toyoncin | Bacillus toyonensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.3 |  | 0.42 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002049.3 |  | 0.39 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0002447.3 |  | 0.39 | ribosomal | cerecyclin | Bacillus cereus
BGC0000487.5 |  | 0.39 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0001576.3 |  | 0.39 | ribosomal | divamide A | Prochloron didemni
BGC0000523.3 |  | 0.38 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000520.5 |  | 0.37 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0002663.2 |  | 0.36 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002442.3 |  | 0.35 | ribosomal | toyoncin | Bacillus toyonensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.18 out of 21.55
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.46 out of 33.14
Confidence: medium
Additional weak hits (3):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.30 out of 39.62
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.30 out of 39.62
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.34 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
ZuR variant 2 | Zinc-responsive repressor

NZ_CP086140.1 - Region 9 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,409,339 - 4,430,169 nt. (total: 20,831 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: halogenase methyltransferase
LL065_RS20955: methyltransferase

smcogs
  SMCOG1089: methyltransferase

LL065_RS20970: halogenase

smcogs
  SMCOG1119: halogenase

Hydrolases: esterase
LL065_RS20995: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

Ligases: synthetase
LL065_RS20940: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.45 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.42 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000244.4 |  | 0.40 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus
BGC0000188.5 |  | 0.38 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0002007.2 |  | 0.38 | terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0000906.3 |  | 0.37 | other (other) | heme D1 | Heliophilum fasciatum
BGC0000905.5 |  | 0.37 | other (other) | heme D1 | Heliobacillus mobilis
BGC0001911.3 |  | 0.36 | terpene | raimonol | Streptomyces anulatus
BGC0001788.3 |  | 0.36 | ribosomal | suicin 65 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.45 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.42 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000244.4 |  | 0.40 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus
BGC0000188.5 |  | 0.38 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0002007.2 |  | 0.38 | terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0000906.3 |  | 0.37 | other (other) | heme D1 | Heliophilum fasciatum
BGC0000905.5 |  | 0.37 | other (other) | heme D1 | Heliobacillus mobilis
BGC0001911.3 |  | 0.36 | terpene | raimonol | Streptomyces anulatus
BGC0001788.3 |  | 0.36 | ribosomal | suicin 65 | Streptococcus suis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
LL065_RS20940: PT_FPPS_like
Domain 1 (37 - 222): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.68 out of 19.52
Confidence: medium
Additional weak hits (2):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
SypG | Regulator of biofilm formation and host colonization

NZ_CP086140.1 - Region 10 - NRPS,cyclic-lactone-autoinducer,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,662,389 - 4,752,902 nt. (total: 90,514 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LL065_RS22120: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: PPTase acylase
LL065_RS22225: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

LL065_RS22230: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase
LL065_RS22220: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
LL065_RS22245: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LL065_RS22250: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

LL065_RS22265: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

LL065_RS22270: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LL065_RS22275: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LL065_RS22280: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  |  | 0.93 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  |  |  | 0.93 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  |  |  | 0.90 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  |  | 0.90 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  |  |  | 0.90 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  |  | 0.90 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001249.5 |  |  |  | 0.87 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001825.4 |  |  |  | 0.86 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  |  |  | 0.86 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002075.3 |  |  |  | 0.85 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.76 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.76 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.75 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  | 0.75 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001249.5 |  | 0.74 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001825.4 |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  | 0.74 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 26.06 out of 26.06
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.13 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.91 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.06 out of 32.93
Confidence: medium
Additional weak hits (7):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.25 out of 27.04
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.78 out of 39.62
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.17 out of 33.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.14 out of 32.74
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.75 out of 27.18
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.47 out of 27.18
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 13, location 4662388 - 4752902:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - Cys - D-Cys) + (D-Ser - Gly - Tyr) + (Me-mal) + (Tyr - Leu) + (mal - Tyr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LL065_RS22230: mal
PKS_AT (6..289): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 70.8%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 92.6
  inactive: 54.2
  Methoxymalonyl-CoA: 44.4
  Methylmalonyl-CoA: 40.7
  Acetyl-CoA: 23.2
  Propionyl-CoA: 19.5
  Isobutyryl-CoA: 10.3
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

LL065_RS22245: Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (650..942): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHYAFDASVSEMTLIVAGSINAYGPTETTVCATD
  Nearest Stachelhaus code(s):
    Tyr DASTIAAVCK (82% 8Å match)
  Stachelhaus code match:
    100% (strong)

LL065_RS22255: Tyr - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (923..1305): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FWRIFDGFGTNSSIVLAGEINEYGPTESSITVTY
  Nearest Stachelhaus code(s):
    meSer DGWSVAVIAK (50% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1947..2330): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASVWEPFLLTGGDVNNYGPTESTVVATY
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

LL065_RS22270: Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (664..946): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWRFFDGFLASAIATLAGEVNEYGPTEATISATI
  Nearest Stachelhaus code(s):
    Tyr DGTITAEVAK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

LL065_RS22275: Ser - Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (473..876): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEHNLYGPTEATVDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1992..2384): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGITFDIFLLELQAMIGGEYNMYGPTETTVWSAI
  Nearest Stachelhaus code(s):
    Gly DILQMGMVWK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

LL065_RS22280: fatty_acid - Cys - Cys
Search NORINE for peptide: strict or relaxed
CAL_domain (36..477): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 126.6
  Acetyl-CoA: 8.7
  shikimic_acid: 0.0
  NH2: 0.0
  AHBA: 0.0

AMP-binding (1134..1512): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNSMLSGDISLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNMSLIWK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2537..2917): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDVSFDLSVYDGNSLLSGDVSLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP086142.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 17,251 - 45,192 nt. (total: 27,942 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
LL065_RS25445: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000562.3 |  |  | 0.74 | ribosomal | variacin | Kocuria varians
BGC0000626.3 |  |  | 0.47 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001210.5 |  |  | 0.46 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000517.4 |  |  | 0.44 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000516.4 |  |  | 0.43 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000539.5 |  |  | 0.40 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000554.4 |  |  | 0.38 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.5 |  |  | 0.38 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000527.5 |  |  | 0.37 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000528.5 |  |  | 0.37 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000562.3 |  | 0.70 | ribosomal | variacin | Kocuria varians
BGC0001210.5 |  | 0.58 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.56 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.55 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000517.4 |  | 0.55 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000539.5 |  | 0.51 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000554.4 |  | 0.51 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.5 |  | 0.51 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000527.5 |  | 0.51 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LL065_RS25445

LL065_RS25425
Leader:
MKTPEKSSIFLKQLAKG
Core:
L I S I G E I H A N Q L C I G P G F Y E P K I P T N L L K S N K
Core with dehydrations:
L I Dha I G E I H A N Q L Cys I G P G F Y E P K I P Dhb N L L K Dha N K

#### antiSMASH-DB 4.0 matches for LL065_RS25425

100.0%
NZ_CP086142.1:
Lanthipeptides: LL065_RS25425_lanthipeptide
1
L I S I G E I H A N Q L C I G P G F Y E P K I P T N L L K S N K
32
L I S I G E I H A N Q L C I G P G F Y E P K I P T N L L K S N K
1
L I S I G E I H A N Q L C I G P G F Y E P K I P T N L L K S N K
32
37.8%
NC_022571.1 and 1 other:
NZ_CP016091.1 Lanthipeptides: CLOBY_RS22135_lanthipeptide
Lanthipeptides: CLSA_RS23015_lanthipeptide
2
I S I G E I H A N Q L C I G P G F Y E P K I P T N L L K S N
31
I + E + C G G Y E K I P L L K N
6
I K L S E N A M E K C C F G-G I Y E T K I P I Q L L K Q N
34
28.1%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS21940_lanthipeptide
13
C I G P G F Y E P K I P T N L L K S N K
32
C G F Y E + P L K +K
1
C F G A L F Y E V E R P E C L K K L D K
20
with 5 more sequence matches
21.9%
NZ_JAQEYW010000015.1:
Lanthipeptides: PG422_RS12370_lanthipeptide
1
L I S I G E I H A N Q L C I G P G F Y E P K I P T N L
27
L S+ +++ +C I +++P K+P +
1
L F S V I A V N S R C V C I---Y H Q P K M P K E M
24
18.8%
NC_015711.1:
Lanthipeptides: allorf_5233543_5233650_lanthipeptide
15
G P G F Y E P K I P T N L L K S N
31
G P ++P++ T L+S+
1
G P Q A W Q P R V V T G P L R S S
17
18.2%
NZ_LVYL01000010.1 and 1 other:
NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05845_lanthipeptide
Lanthipeptides: A3863_RS05845_lanthipeptide
18
F Y E P K I P T N L L K S N
31
F+E ++P L K+N
8
F H E D E V P E E L Q K N N
21
14.6%
NZ_LR130759.1:
Lanthipeptides: allorf_5440180_5440359_lanthipeptide
15
G P G F Y E P K I P T N L L K S N K
32
G P G+ +P N L ++ +
5
G P G Y R R R C V P G N L A E A R R
22
12.0%
NZ_JAGKQT010000007.1 and 1 other:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09870_lanthipeptide
Lanthipeptides: J2M30_RS09870_lanthipeptide
18
F Y E P K I P T N L L K S N
31
F+E ++P L K N
25
F H E D E V P E E L Q K D N
38
LL065_RS25450
Leader:
MKKLNEEALEAINDVTDEELEKLTGA
LL065_RS25455
Leader:
MKKLNEEALEAINDVTDEELEKLTGA
LL065_RS25460
Leader:
MKKLNEEALEAINDVTDEELEKLTGA
LL065_RS25465
Leader:
MKKLNEEALEAINDVTDEELEKLTGA
Shared core:
G G G V I T T F T H E C Y Y N S V S P A S W G G C C K
Core with dehydrations:
G G G V I Dhb Dhb F Dhb H E Cys Y Y N Dha V Dha P A Dha W G G Cys Cys K

#### antiSMASH-DB 4.0 matches for LL065_RS25450

100.0%
NZ_CP086142.1 and 3 others:
NZ_CP086142.1 Lanthipeptides: LL065_RS25460_lanthipeptide NZ_CP086142.1 Lanthipeptides: LL065_RS25455_lanthipeptide NZ_CP086142.1 Lanthipeptides: LL065_RS25450_lanthipeptide
Lanthipeptides: LL065_RS25465_lanthipeptide
1
G G G V I T T F T H E C Y Y N S V S P A S W G G C C K
27
G G G V I T T F T H E C Y Y N S V S P A S W G G C C K
1
G G G V I T T F T H E C Y Y N S V S P A S W G G C C K
27
96.3%
NZ_CP077726.1 and 12 others:
NZ_CP077726.1 Lanthipeptides: KTC92_RS18420_lanthipeptide NZ_CP077726.1 Lanthipeptides: KTC92_RS18415_lanthipeptide NZ_CP077726.1 Lanthipeptides: KTC92_RS18410_lanthipeptide NZ_CP077726.1 Lanthipeptides: KTC92_RS18405_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19070_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19065_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19060_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19055_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19050_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19045_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19040_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19035_lanthipeptide
Lanthipeptides: KTC92_RS18425_lanthipeptide
1
G G G V I T T F T H E C Y Y N S V S P A S W G G C C K
27
G G V I T T F T H E C Y Y N S V S P A S W G G C C K
1
G N G V I T T F T H E C Y Y N S V S P A S W G G C C K
27
58.1%
NZ_CP034248.1:
Lanthipeptides: EIM92_RS14995_lanthipeptide
2
G G V I T T F T H E C Y Y N S V S P A S W G G C C
26
G G V I T +H E C+Y N S V S P A+W C C
7
G G V I C T I S H E C H Y N S V S P A A W A T C C
31
with 50 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_CAKMMP010000011.1 and 5 others:
NZ_CP018620.1 Lanthipeptides: BS614_RS05680_lanthipeptide NZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptide NZ_FMVM01000006.1 Lanthipeptides: BLQ13_RS10365_lanthipeptide NZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptide NZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide
Lanthipeptides: L6H98_RS19925_lanthipeptide
1
G G G V I T T F T H E C Y Y N S V S P A S W G G C C
26
G G V T +H E C+Y N S V S P+S W C C
9
S G G V F C T V S H E C H Y N S V S P S S W L T C C
34
44.4%
NZ_MSRJ01000005.1:
Lanthipeptides: BKH06_RS03750_lanthipeptide
1
G G G V I T T F T H E C Y Y N S V S P A
20
G G V T F T H E C N S A
1
G N G V F Y T F T H E C N T N S F Y V A
20
41.4%
NZ_JAGFVL010000062.1:
Lanthipeptides: J5J03_RS19425_lanthipeptide
1
G G G V I T T F T H E C Y-Y N S V S P A S W G G C C
26
G G I +F T +C N ++ S W G C C
3
G P G W I P S F T G D C T C D N G I T V C S W S G C C
29
40.7%
NZ_GL985606.1:
Lanthipeptides: HMPREF9062_RS00700_lanthipeptide
1
G G G V I T T F T H E C Y Y N S
16
G G V T +H E C Y Y N S
1
G N G V F H T I S H E C Y Y N S
16
40.7%
NZ_VDNV01000006.1:
Lanthipeptides: FSV44_RS08765_lanthipeptide
1
G G G V I T T F T H E C Y Y N S
16
G G G V I T +H E C N S
1
G G G V I Q T I S H E C R M N S
16
37.0%
NZ_CP026729.1:
Lanthipeptides: BKKJ1_RS07010_lanthipeptide
1
G G G V I T T F T H E C Y Y N S
16
G G V+T T +H E C N S
1
G N G V V T T I S H E C N M N S
16
37.0%
NZ_CP031746.1:
Lanthipeptides: DCC27_RS08165_lanthipeptide
3
G V I T T F T H E C Y Y N S
16
G V I+T T H E C+ N S
2
G V I S T L T H E C H M N S
15
37.0%
NZ_CP037940.1:
Lanthipeptides: EQG49_RS07315_lanthipeptide
1
G G G V I T T F T H E C Y Y N S
16
G G V I T T H E C N+
4
G S G V I K T L T H E C K M N T
19
37.0%
NZ_CP069183.1:
Lanthipeptides: LLNCDO700_RS13730_lanthipeptide
1
G G G V I T T F T H E C Y Y N S
16
G G V I T +H E C N S
3
G S G V I H T I S H E C N M N S
18
37.0%
NZ_CP072384.1:
Lanthipeptides: J5A65_RS01395_lanthipeptide
1
G G G V I T T F T H E C Y Y N S
16
G G V+ T T H E C+ N S
1
G R G V V P T V T H E C H M N S
16
allorf_022513_022629
Leader:
MSVIRLRNVGYG
Core:
L L D K Y I V T L Y S Y I L T T F W K L Q V C H I L
Core with dehydrations:
L L D K Y I V Dhb L Y Dha Y I L Dhb Dhb F W K L Q V Cys H I L

#### antiSMASH-DB 4.0 matches for allorf_022513_022629

100.0%
NZ_CP086142.1:
Lanthipeptides: allorf_022513_022629_lanthipeptide
1
L L D K Y I V T L Y S Y I L T T F W K L Q V C H I L
26
L L D K Y I V T L Y S Y I L T T F W K L Q V C H I L
1
L L D K Y I V T L Y S Y I L T T F W K L Q V C H I L
26
27.6%
NZ_FOHE01000012.1:
Lanthipeptides: BMX40_RS20340_lanthipeptide
7
V T L Y S Y I L T T F W K
19
+T S I L T T F W
7
I T T V S A I L T T F W S
19
allorf_039242_039433
Leader:
MFYLRLWYLYTINKSYISNSLHIVAFTLHIGVCVVMERKAGIGS
Core:
I K F T S W N C S Y K L Q I F V G I S
Core with dehydrations:
I K F Dhb Dha W N Cys Dha Y K L Q I F V G I Dha

#### antiSMASH-DB 4.0 matches for allorf_039242_039433

100.0%
NZ_CP086142.1:
Lanthipeptides: allorf_039242_039433_lanthipeptide
1
I K F T S W N C S Y K L Q I F V G I S
19
I K F T S W N C S Y K L Q I F V G I S
1
I K F T S W N C S Y K L Q I F V G I S
19
31.6%
NZ_CP028721.1:
Lanthipeptides: allorf_32905_33036_lanthipeptide
3
F T S W N C S Y K L Q I F V
16
F W C S+ ++F V
2
F R V W P C S W Y K K L F V
15
17.9%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08030_lanthipeptide
4
T S W N C S Y K L Q I F V G I S
19
T+ C+Y + + +G I+
7
T T T P C A Y T I G V T I G I T
22
allorf_042105_042275
Leader:
MNISIYMMYCECNIFNQSFLGRKGIHMRIGA
Core:
V I K N K L T R R A L L L G F I F Y D C S F N T L
Core with dehydrations:
V I K N K L Dhb R R A L L L G F I F Y D Cys Dha F N Dhb L

#### antiSMASH-DB 4.0 matches for allorf_042105_042275

100.0%
NZ_CP086142.1:
Lanthipeptides: allorf_042105_042275_lanthipeptide
1
V I K N K L T R R A L L L G F I F Y D C S F N T L
25
V I K N K L T R R A L L L G F I F Y D C S F N T L
1
V I K N K L T R R A L L L G F I F Y D C S F N T L
25
13.3%
NZ_CP077726.1:
Lanthipeptides: KTC92_RS18445_lanthipeptide
12
L L G F I F Y D C S F N
23
+ G I F D C S
14
V S G I I F V D C S H E
25

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
Additional weak hits (2):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.74 out of 31.73
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.12 out of 27.04
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LL065_RS25425 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 3452.9 Da
  Molecular weight: 3455.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3473.0 Da N = 1
    3491.1 Da N = 2
LL065_RS25450 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 2715.2 Da
  Molecular weight: 2717.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2735.0 Da N = 1
    2753.0 Da N = 2
    2771.1 Da N = 3
LL065_RS25455 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 2715.2 Da
  Molecular weight: 2717.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2735.0 Da N = 1
    2753.0 Da N = 2
    2771.1 Da N = 3
LL065_RS25460 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 2715.2 Da
  Molecular weight: 2717.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2735.0 Da N = 1
    2753.0 Da N = 2
    2771.1 Da N = 3
LL065_RS25465 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 2715.2 Da
  Molecular weight: 2717.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2735.0 Da N = 1
    2753.0 Da N = 2
    2771.1 Da N = 3
allorf_022513_022629 - Class II
  Cleavage pHMM score: -2.90
  RODEO score: 0
  Monoisotopic mass: 3113.8 Da
  Molecular weight: 3115.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3133.8 Da N = 1
    3151.8 Da N = 2
    3169.8 Da N = 3
allorf_039242_039433 - Class II
  Cleavage pHMM score: -4.30
  RODEO score: 0
  Monoisotopic mass: 2161.2 Da
  Molecular weight: 2162.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2180.6 Da N = 1
    2198.6 Da N = 2
    2216.6 Da N = 3
allorf_042105_042275 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 2890.6 Da
  Molecular weight: 2892.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2910.5 Da N = 1
    2928.5 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
MogR | Repressor of flagellar motility genes

NZ_CP086145.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,351 nt. (total: 16,351 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
LL065_RS26225: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
LL065_RS26240: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.50 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.50 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000554.4 |  | 0.47 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001407.5 |  | 0.44 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000523.3 |  | 0.43 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000626.3 |  | 0.42 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000502.5 |  | 0.42 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.50 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.50 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000554.4 |  | 0.47 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001407.5 |  | 0.44 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000523.3 |  | 0.43 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000626.3 |  | 0.42 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000502.5 |  | 0.42 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LL065_RS26240

LL065_RS26230
Leader:
MIKEFDPAGIVDLSELDELANIGGS
Core:
D V Q A Q T T P T I A S F L V S V I S I E L T A S A V T V T A A C L
Core with dehydrations:
D V Q A Q Dhb Dhb P Dhb I A Dha F L V Dha V I Dha I E L Dhb A Dha A V Dhb V Dhb A A Cys L

#### antiSMASH-DB 4.0 matches for LL065_RS26230

100.0%
NZ_CP086145.1:
Lanthipeptides: LL065_RS26230_lanthipeptide
1
D V Q A Q T T P T I A S F L V S V I S I E L T A S A V T V T A A C L
34
D V Q A Q T T P T I A S F L V S V I S I E L T A S A V T V T A A C L
1
D V Q A Q T T P T I A S F L V S V I S I E L T A S A V T V T A A C L
34
82.4%
NZ_CP084663.1:
Lanthipeptides: LA357_RS19865_lanthipeptide
1
D V Q A Q T T P T I A S F L V S V I S I E L T A S A V T V T A A C L
34
D V+A Q T T P T I A S L V S V I S+E L T S A T V T A C L
1
D V E A Q T T P T I A S V L V S V I S V E L T V S A A T V T A Q C L
34
44.7%
NZ_CP091282.1:
Lanthipeptides: L2Z53_RS12190_lanthipeptide
1
D V Q A Q T T P--T I A S F L V S V-I S I E L T A S-A V T V T A A C
33
D V +T T P T I++F L+S V E L+ A T V C
2
D V N V E T T P T A T I S A F L L S V G G G Y E L S I H V A K T V K G K C
38
with 48 more sequence matches
Only the first 10 are displayed here.
37.5%
NZ_FPCC01000026.1:
Lanthipeptides: BM377_RS12935_lanthipeptide
1
D V Q A Q T T P T I A S F L V S V I S I E L T A S A-V T V T A A C
33
D V A+T T P I V I L A V V T C
2
D V D A E T T P A I T V S A A V V I G G S L G F E A T V K V T K T C
35
35.3%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide
Lanthipeptides: BEH_RS02100_lanthipeptide
1
D V Q A Q T T P T I A S F L V S V I S I E L T A S A V T V T A A C
33
D V Q A+T T P +I L A+ A C
2
D V Q A E T T P V-------C F T I G L G V G A L V S A A G C
27
35.3%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26125_lanthipeptide
1
D V Q A Q T T P T-I A S F L V S V I S I E L T A S A
26
D V+ +T T P +A F V + I A S A
2
D V K P E T T P A C L A G F T V G-L G I G A L A S A
27
35.3%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide
Lanthipeptides: COK11_RS25885_lanthipeptide
1
D V Q A Q T T P T-I A S F L V S V I S I E L T A S A V T V T A A C
33
D V+ +T T P +A F +I L A+ A C
2
D V K P E T T P A C L A G F-----T I G L G I G A L A S A A G C
30
34.9%
NZ_GG730336.1:
Lanthipeptides: SAUG_RS08755_lanthipeptide
2
V Q A Q T T P T I A S F L V S V---I S I E L T A S A V T
28
V+ Q T P T I A S I S I T S A V+
4
V E P Q A T P T I A S P F T P Y A I E I S I G A T V S A V S
33
34.8%
NZ_QXPZ01000025.1:
Lanthipeptides: D3H64_RS06235_lanthipeptide
1
D V Q A Q T T P T I A S F L V S V I S I E L T A-S A V T V
29
D Q A+T T P T+ + L + E L T A S A+T V
3
D A Q A R T T P T V V A P L T T P---E L T A I S A L T V
29
34.3%
NZ_PVRU01000017.1 and 3 others:
NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28255_lanthipeptide NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28260_lanthipeptide NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28255_lanthipeptide
Lanthipeptides: C6360_RS28260_lanthipeptide
1
D V Q A Q T T P T I A S F L V S V I S I E L T A S A V T V T A A
32
D V Q +T T P A+ + S + L A+ +T++ A
2
D V Q P E T T P A-A T L I T S T V---L C A N G L T I S I A
29
32.4%
NZ_JAEKEJ010000007.1:
Lanthipeptides: JFU02_RS02780_lanthipeptide
1
D V Q A Q T T P T I A S--F L V S V I S I E L T A S
25
D V Q +T T P S + + I+I L S
2
D V Q P E T T P L C V S T I W Y A N G I T I G L A L S
28
32.4%
NZ_SDJV01000024.1:
Lanthipeptides: ES032_RS12700_lanthipeptide
1
D V Q A Q T T P T I---A S F L V S
16
D V Q +T T P A S L V S
2
D V Q V E T T P A C A F T A S I L V S
20
29.8%
NZ_JAKVIH010000006.1 and 1 other:
NZ_JAQEOM010000007.1 Lanthipeptides: PGW12_RS04385_lanthipeptide
Lanthipeptides: MK858_RS03865_lanthipeptide
1
D V Q A Q T T P T I A S F L V S V I S I E L T A-S A V T V T
30
+V Q ++T P T+ V + + E L T A S A+T V+
3
E V Q P R S T P T V T---V P I A T P E L T A I S A L T V S
30

#### MIBiG 4.0 matches for LL065_RS26230

21.6%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
6
T T P T I A S F L V S V I S I E L T A S A V T V T A A
32
T P + ++ +++I+ A V V+A A
1
T D P A V T G L I L G I V A I Q-A G V A V G V S A A
26
14.7%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
7
T P T I A S F L V
15
T P T+A F++
5
T P T V A Q F V I
13

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.54 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.92 out of 32.93
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.73 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.79 out of 18.16
Confidence: strong
Additional weak hits (4):
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.26 out of 32.38
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.23 out of 29.51
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 18.33 out of 29.51
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LL065_RS26230 - Class II
  Cleavage pHMM score: -0.50
  RODEO score: 0
  Monoisotopic mass: 3239.8 Da
  Molecular weight: 3241.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3259.7 Da N = 1
    3277.7 Da N = 2
    3295.8 Da N = 3
    3313.8 Da N = 4
    3331.8 Da N = 5
    3349.8 Da N = 6
    3367.8 Da N = 7
    3385.9 Da N = 8
    3403.9 Da N = 9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3 | Repressor of DNA damage response
RpoN | Regulator of nitrogen assimilation and virulence
ZuR variant 1 | Zinc-responsive repressor

NZ_CP086141.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 264,922 - 15,917 nt. (total: 20,585 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LL065_RS23875: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.36 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002284.3 |  | 0.31 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000607.5 |  | 0.31 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0002667.2 |  | 0.31 | ribosomal | estericin A | Clostridium estertheticum
BGC0001098.5 |  | 0.30 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001090.5 |  | 0.30 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0002307.3 |  | 0.27 | ribosomal | humidimycin | Streptomyces humidus
BGC0002015.4 |  | 0.27 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001674.5 |  | 0.27 | ribosomal | MS-271 | Streptomyces mirabilis
BGC0001920.4 |  | 0.27 | ribosomal | siamycin I | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.36 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002284.3 |  | 0.31 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000607.5 |  | 0.31 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0002667.2 |  | 0.31 | ribosomal | estericin A | Clostridium estertheticum
BGC0001098.5 |  | 0.30 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001090.5 |  | 0.30 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0002307.3 |  | 0.27 | ribosomal | humidimycin | Streptomyces humidus
BGC0002015.4 |  | 0.27 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001674.5 |  | 0.27 | ribosomal | MS-271 | Streptomyces mirabilis
BGC0001920.4 |  | 0.27 | ribosomal | siamycin I | Streptomyces sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 21.74 out of 23.79
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.58 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.53 out of 30.25
Confidence: medium
Additional weak hits (2):
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.04 out of 27.18
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.02 out of 20.47
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism

NZ_CP086141.1 - Region 2 - lanthipeptide-class-i,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 150,029 - 194,775 nt. (total: 44,747 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
LL065_RS24705: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Lyases: cyclase dehydratase
LL065_RS24725: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

LL065_RS24730: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

LL065_RS24775: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

LL065_RS24805: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002698.2 |  |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002699.2 |  |  | 0.48 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0001391.3 |  |  | 0.46 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0002576.2 |  |  | 0.44 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001210.5 |  |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  |  | 0.42 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000525.5 |  |  | 0.41 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.4 |  |  | 0.41 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000554.4 |  |  | 0.41 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001229.4 |  |  | 0.40 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0002698.2 |  | 0.58 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002699.2 |  | 0.57 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0001391.3 |  | 0.56 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.56 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.55 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001289.5 |  | 0.55 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000626.3 |  | 0.54 | ribosomal | thuricin | Bacillus thuringiensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LL065_RS24725

LL065_RS24720
Leader:
MIKMANFDDFDLDININKASAKVSQSFPT
Core:
Q S G G F N T N T I S I C S V P C T F P I T T I T V A C T K
Core with dehydrations:
Q Dha G G F N Dhb N Dhb I Dha I Cys Dha V P Cys Dhb F P I Dhb Dhb I Dhb V A Cys Dhb K

#### antiSMASH-DB 4.0 matches for LL065_RS24720

100.0%
NZ_CP086141.1:
Lanthipeptides: LL065_RS24720_lanthipeptide
1
Q S G G F N T N T I S I C S V P C T F P I T T I T V A C T K
30
Q S G G F N T N T I S I C S V P C T F P I T T I T V A C T K
1
Q S G G F N T N T I S I C S V P C T F P I T T I T V A C T K
30
33.3%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
8
N T I S I C S V P C T F P I T T I T V A C
28
N I S I ++P T T+T V C
2
N L I S I T T I P F T H L C A T V T V G C
22

#### MIBiG 4.0 matches for LL065_RS24720

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
23
T I T V A C
28
T+T V C
18
T L T V E C
23
13.3%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
14
S V P C T
18
S P C T
2
S A P C T
6

#### Lanthipeptide(s) for LL065_RS24775

LL065_RS24780
Leader:
MIKNNEICKNAGFISEDELVELVDSSDINGGTTPV
Core:
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
Core with dehydrations:
V Dha A I Dha A Dhb V A Dha A Dhb A V Dha A L F Dhb V Dhb Dha A Cys Dhb K Dha Cys N K

#### antiSMASH-DB 4.0 matches for LL065_RS24780

100.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
88.2%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
30
82.4%
NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide
Lanthipeptides: OCU69_RS05005_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
+T P+V S A I S A T V A S A T A+S A L F T V T S A C T C K
1
S T P I V S A I S A T V A S A T A I S A L F T V T S A C T T K C G K
34
with 39 more sequence matches
Only the first 10 are displayed here.
64.7%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03100_lanthipeptide
Lanthipeptides: H04402_RS03100_lanthipeptide
8
I S A T V A S A T A V S A L F T V T S A C T K S C N
33
+S A T V A S A T A V S A L F T V T S A C T C
1
V S A T V A S A T A V S A L F T V T S A C T T K C K
26
52.8%
NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12785_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide
Lanthipeptides: GTU71_RS12785_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V T S A C-T K S C
32
++S A+S T V A S A T A V S A L T + C T S C
3
I I S A V S G T V A S A T A V S A L V T S S G L C P T F S C
32
48.6%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V-T S A C T K S C N K
34
+V+A I S A T A V+A T S A C+K S C N K
10
I V T A I S A V----T A V T A Q S P C P T S A C S K S C N K
37
44.1%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
8
I S A T V A S A T A V S A L F T---V T S A C T K S C
32
I S A T V A S T A+S A + T+ C T C
1
I S A T V A S V T A I S A A W G D G C P T T V C T S R C
28
41.2%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T T P V+ S A + S V S+ T+A C T++C
1
T T P V I-G Y S A V I V S G-F V S S H T C P T T A C T R A C
30
41.0%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
2
T P V V S A I S A T V A S A T A-V S A L F T V T S A C T K S C
32
T P A I V + T A V S A T S A C T++C
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
38.9%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I I T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.9%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I L T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.2%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T P V+ A+S A V+ T T+A C T++C
8
T P V I V A V S A Y V S D K T C P------T T A C T R A C
32
38.2%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00070_lanthipeptide
Lanthipeptides: GHI93_RS00070_lanthipeptide
16
T A V S A L F T V T S A C T K S C
32
T A V S A L F +T+A C+K S C
1
T A V S A L F G I T T A C S K S C
17

#### MIBiG 4.0 matches for LL065_RS24780

35.1%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
+ A I A V A V S A F T+ C T C
12
I V A I Q A G V A--V G V S A A F C P T T K C T S R C
37
20.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
S A L F T V T S A C T K S C N
33
A T+T C S C N
14
G A Y C T L T V E C M P S C N
28
14.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
23
T V T S A C T K S C N
33
T+T C +C N
20
T L T K E C Q P N C N
30
LL065_RS24780
Leader:
MIKNNEICKNAGFISEDELVELVDSSDINGG
Core:
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
Core with dehydrations:
Dhb Dhb P V V Dha A I Dha A Dhb V A Dha A Dhb A V Dha A L F Dhb V Dhb Dha A Cys Dhb K Dha Cys N K

#### antiSMASH-DB 4.0 matches for LL065_RS24780

100.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
88.2%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
30
82.4%
NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide
Lanthipeptides: OCU69_RS05005_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
+T P+V S A I S A T V A S A T A+S A L F T V T S A C T C K
1
S T P I V S A I S A T V A S A T A I S A L F T V T S A C T T K C G K
34
with 39 more sequence matches
Only the first 10 are displayed here.
64.7%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03100_lanthipeptide
Lanthipeptides: H04402_RS03100_lanthipeptide
8
I S A T V A S A T A V S A L F T V T S A C T K S C N
33
+S A T V A S A T A V S A L F T V T S A C T C
1
V S A T V A S A T A V S A L F T V T S A C T T K C K
26
52.8%
NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12785_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide
Lanthipeptides: GTU71_RS12785_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V T S A C-T K S C
32
++S A+S T V A S A T A V S A L T + C T S C
3
I I S A V S G T V A S A T A V S A L V T S S G L C P T F S C
32
48.6%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V-T S A C T K S C N K
34
+V+A I S A T A V+A T S A C+K S C N K
10
I V T A I S A V----T A V T A Q S P C P T S A C S K S C N K
37
44.1%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
8
I S A T V A S A T A V S A L F T---V T S A C T K S C
32
I S A T V A S T A+S A + T+ C T C
1
I S A T V A S V T A I S A A W G D G C P T T V C T S R C
28
41.2%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T T P V+ S A + S V S+ T+A C T++C
1
T T P V I-G Y S A V I V S G-F V S S H T C P T T A C T R A C
30
41.0%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
2
T P V V S A I S A T V A S A T A-V S A L F T V T S A C T K S C
32
T P A I V + T A V S A T S A C T++C
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
38.9%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I I T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.9%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I L T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.2%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T P V+ A+S A V+ T T+A C T++C
8
T P V I V A V S A Y V S D K T C P------T T A C T R A C
32
38.2%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00070_lanthipeptide
Lanthipeptides: GHI93_RS00070_lanthipeptide
16
T A V S A L F T V T S A C T K S C
32
T A V S A L F +T+A C+K S C
1
T A V S A L F G I T T A C S K S C
17

#### MIBiG 4.0 matches for LL065_RS24780

35.1%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
+ A I A V A V S A F T+ C T C
12
I V A I Q A G V A--V G V S A A F C P T T K C T S R C
37
20.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
S A L F T V T S A C T K S C N
33
A T+T C S C N
14
G A Y C T L T V E C M P S C N
28
14.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
23
T V T S A C T K S C N
33
T+T C +C N
20
T L T K E C Q P N C N
30
LL065_RS24800
Leader:
MIKNPIMRTKLHQIEEFPCGDLFEEINENSMTMDAVNGG
Core:
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
Core with dehydrations:
G W V Dha Dhb I L Q G Dhb V G Cys L A Dha Y A L G N Q G K I Cys Dhb W Dha V E Cys Q N N Cys

#### antiSMASH-DB 4.0 matches for LL065_RS24800

100.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide
Lanthipeptides: LL065_RS24800_lanthipeptide
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
50.0%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
5
T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
T +G T+ S +G N G K+C T W+V E C Q N N C
1
T F S E G T I S I T L S V Y M G N D G K V C T W T V E C Q N N C
32
47.4%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
10
T V G C L-A S Y A L G N Q G K I C T W S V E C Q N N C
36
T+ C L A S Y A L G++G++C T +V E C N N C
9
T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
with 100 more sequence matches
Only the first 10 are displayed here.
47.4%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
1
G W V S T I L Q G T V G C L-A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W +T+ ++ C A S Y L G N G C T + E C Q+N C
3
G W G T T L--S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C
37
47.2%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
5
T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
T I + +A S+A L G N G +C T +V E C Q N C
1
T I F E T V T Y T V A S W A L G N N G H L C T V T V E C Q K N C
32
46.2%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
1
G W V S T I L Q G T V G C L A-S Y A L G N Q G K I C T W S V E C Q N N C
36
G W +T I ++ C S+ G N G++C T +V E C Q N N C
4
G W T T T I T--S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
45.9%
NZ_BCEY01000006.1 and 1 other:
NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide
Lanthipeptides: GOZ53_RS01290_lanthipeptide
6
I L Q G T V G C-L A S Y A L G N Q G K I C T W S V E C Q N N C
36
+ + V C L S+A L G N G I C T W+ E C Q C
5
V A K S I V S C S L I S F A L G N D G W I C T W T A E C Q A T C
36
45.9%
NZ_VTZW01000015.1 and 1 other:
NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15850_lanthipeptide
Lanthipeptides: FZ103_RS15850_lanthipeptide
5
T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
+I V C L A S+A+G N+G C T +V E C Q+ C
6
S I A T A C V S C L A S W A V G N E G W A C T V T V E C Q D G C
37
45.0%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
2
W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
W T I L A S Y L G N G +C T +V E C Q C
5
W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C
39
44.7%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
7
L Q G T V G C L A-S Y A L G N Q G K I C T W S V E C Q N N C
36
L T+ C L A S +G++G++C T +V E C Q N N C
6
L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C
36
44.4%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
9
G T V G C L A-S Y A L G N Q G K I C T W S V E C Q N N C
36
T C+A S+ +G N G K+C T++V E C N N C
7
S T S T C I A V S H F V G N D G K V C T Y T V E C V N N C
35
44.4%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide
Lanthipeptides: GHI93_RS00065_lanthipeptide
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W ++ +V + A L G N G +C T W+ E C Q N C
1
G W T W N L V F S S V---V T L A L G N N G Y V C T W T H E C Q A N C
33
43.2%
NC_015215.1 and 5 others:
NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide
Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W T L S L G N G +C T W+ E C Q C
1
G W T G V A K S I T S C S L L S I G L G N D G W V C T W T A E C Q A T C
36

#### MIBiG 4.0 matches for LL065_RS24800

36.1%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
S Y A L G N Q G K I C T W S V E C Q N N C
36
S A L G N G C T + E C Q N C
9
S N A L G N N G G W C T L T K E C Q P N C
29
27.8%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
L G N Q G K I C T W S V E C Q N N C
36
L G N+G C T +V E C +C
10
L G N K G A Y C T L T V E C M P S C
27
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
26
C T W S V E C Q N N C
36
C T S E C Q N C
28
C T L S K E C Q P N C
38
with 3 more sequence matches
11.1%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
6
I L Q G T V G C L
14
++Q G+ C L
12
V I Q G S T I C L
20
11.1%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
1
G W V S T I
6
W S T I
14
A W A S T I
19
11.1%
BGC0002111.3 (EVG22_32245)and 1 other:
BGC0002111.3 (multiple genes) Lanthipeptide: andalusicin A or andalusicin B
Lanthipeptide: andalusicin A or andalusicin B
28
W S V E C Q N N C
36
W+ N N C
15
W A S T I S N N C
23

#### Lanthipeptide(s) for LL065_RS24805

LL065_RS24780
Leader:
MIKNNEICKNAGFISEDELVELVDSSDINGGTTPV
Core:
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
Core with dehydrations:
V Dha A I Dha A Dhb V A Dha A Dhb A V Dha A L F Dhb V Dhb Dha A Cys Dhb K Dha Cys N K

#### antiSMASH-DB 4.0 matches for LL065_RS24780

100.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
88.2%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
30
82.4%
NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide
Lanthipeptides: OCU69_RS05005_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
+T P+V S A I S A T V A S A T A+S A L F T V T S A C T C K
1
S T P I V S A I S A T V A S A T A I S A L F T V T S A C T T K C G K
34
with 39 more sequence matches
Only the first 10 are displayed here.
64.7%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03100_lanthipeptide
Lanthipeptides: H04402_RS03100_lanthipeptide
8
I S A T V A S A T A V S A L F T V T S A C T K S C N
33
+S A T V A S A T A V S A L F T V T S A C T C
1
V S A T V A S A T A V S A L F T V T S A C T T K C K
26
52.8%
NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12785_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide
Lanthipeptides: GTU71_RS12785_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V T S A C-T K S C
32
++S A+S T V A S A T A V S A L T + C T S C
3
I I S A V S G T V A S A T A V S A L V T S S G L C P T F S C
32
48.6%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V-T S A C T K S C N K
34
+V+A I S A T A V+A T S A C+K S C N K
10
I V T A I S A V----T A V T A Q S P C P T S A C S K S C N K
37
44.1%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
8
I S A T V A S A T A V S A L F T---V T S A C T K S C
32
I S A T V A S T A+S A + T+ C T C
1
I S A T V A S V T A I S A A W G D G C P T T V C T S R C
28
41.2%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T T P V+ S A + S V S+ T+A C T++C
1
T T P V I-G Y S A V I V S G-F V S S H T C P T T A C T R A C
30
41.0%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
2
T P V V S A I S A T V A S A T A-V S A L F T V T S A C T K S C
32
T P A I V + T A V S A T S A C T++C
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
38.9%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I I T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.9%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I L T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.2%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T P V+ A+S A V+ T T+A C T++C
8
T P V I V A V S A Y V S D K T C P------T T A C T R A C
32
38.2%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00070_lanthipeptide
Lanthipeptides: GHI93_RS00070_lanthipeptide
16
T A V S A L F T V T S A C T K S C
32
T A V S A L F +T+A C+K S C
1
T A V S A L F G I T T A C S K S C
17

#### MIBiG 4.0 matches for LL065_RS24780

35.1%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
+ A I A V A V S A F T+ C T C
12
I V A I Q A G V A--V G V S A A F C P T T K C T S R C
37
20.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
S A L F T V T S A C T K S C N
33
A T+T C S C N
14
G A Y C T L T V E C M P S C N
28
14.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
23
T V T S A C T K S C N
33
T+T C +C N
20
T L T K E C Q P N C N
30
LL065_RS24780
Leader:
MIKNNEICKNAGFISEDELVELVDSSDINGG
Core:
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
Core with dehydrations:
Dhb Dhb P V V Dha A I Dha A Dhb V A Dha A Dhb A V Dha A L F Dhb V Dhb Dha A Cys Dhb K Dha Cys N K

#### antiSMASH-DB 4.0 matches for LL065_RS24780

100.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
88.2%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
1
V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
30
82.4%
NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide
Lanthipeptides: OCU69_RS05005_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
+T P+V S A I S A T V A S A T A+S A L F T V T S A C T C K
1
S T P I V S A I S A T V A S A T A I S A L F T V T S A C T T K C G K
34
with 39 more sequence matches
Only the first 10 are displayed here.
64.7%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03100_lanthipeptide
Lanthipeptides: H04402_RS03100_lanthipeptide
8
I S A T V A S A T A V S A L F T V T S A C T K S C N
33
+S A T V A S A T A V S A L F T V T S A C T C
1
V S A T V A S A T A V S A L F T V T S A C T T K C K
26
52.8%
NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12785_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide
Lanthipeptides: GTU71_RS12785_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V T S A C-T K S C
32
++S A+S T V A S A T A V S A L T + C T S C
3
I I S A V S G T V A S A T A V S A L V T S S G L C P T F S C
32
48.6%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
4
V V S A I S A T V A S A T A V S A L F T V-T S A C T K S C N K
34
+V+A I S A T A V+A T S A C+K S C N K
10
I V T A I S A V----T A V T A Q S P C P T S A C S K S C N K
37
44.1%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
8
I S A T V A S A T A V S A L F T---V T S A C T K S C
32
I S A T V A S T A+S A + T+ C T C
1
I S A T V A S V T A I S A A W G D G C P T T V C T S R C
28
41.2%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T T P V+ S A + S V S+ T+A C T++C
1
T T P V I-G Y S A V I V S G-F V S S H T C P T T A C T R A C
30
41.0%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
2
T P V V S A I S A T V A S A T A-V S A L F T V T S A C T K S C
32
T P A I V + T A V S A T S A C T++C
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
38.9%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I I T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.9%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C N K
34
T +++A++ T + T +S A T S A C T C N K
5
T A I L T A L T G T T F T V T-L S A A S C P T S A C T N L C N K
36
38.2%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
2
T P V V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
T P V+ A+S A V+ T T+A C T++C
8
T P V I V A V S A Y V S D K T C P------T T A C T R A C
32
38.2%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00070_lanthipeptide
Lanthipeptides: GHI93_RS00070_lanthipeptide
16
T A V S A L F T V T S A C T K S C
32
T A V S A L F +T+A C+K S C
1
T A V S A L F G I T T A C S K S C
17

#### MIBiG 4.0 matches for LL065_RS24780

35.1%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
5
V S A I S A T V A S A T A V S A L F T V T S A C T K S C
32
+ A I A V A V S A F T+ C T C
12
I V A I Q A G V A--V G V S A A F C P T T K C T S R C
37
20.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
S A L F T V T S A C T K S C N
33
A T+T C S C N
14
G A Y C T L T V E C M P S C N
28
14.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
23
T V T S A C T K S C N
33
T+T C +C N
20
T L T K E C Q P N C N
30
LL065_RS24800
Leader:
MIKNPIMRTKLHQIEEFPCGDLFEEINENSMTMDAVNGG
Core:
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
Core with dehydrations:
G W V Dha Dhb I L Q G Dhb V G Cys L A Dha Y A L G N Q G K I Cys Dhb W Dha V E Cys Q N N Cys

#### antiSMASH-DB 4.0 matches for LL065_RS24800

100.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide
Lanthipeptides: LL065_RS24800_lanthipeptide
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
50.0%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
5
T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
T +G T+ S +G N G K+C T W+V E C Q N N C
1
T F S E G T I S I T L S V Y M G N D G K V C T W T V E C Q N N C
32
47.4%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
10
T V G C L-A S Y A L G N Q G K I C T W S V E C Q N N C
36
T+ C L A S Y A L G++G++C T +V E C N N C
9
T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
with 100 more sequence matches
Only the first 10 are displayed here.
47.4%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
1
G W V S T I L Q G T V G C L-A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W +T+ ++ C A S Y L G N G C T + E C Q+N C
3
G W G T T L--S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C
37
47.2%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
5
T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
T I + +A S+A L G N G +C T +V E C Q N C
1
T I F E T V T Y T V A S W A L G N N G H L C T V T V E C Q K N C
32
46.2%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
1
G W V S T I L Q G T V G C L A-S Y A L G N Q G K I C T W S V E C Q N N C
36
G W +T I ++ C S+ G N G++C T +V E C Q N N C
4
G W T T T I T--S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
45.9%
NZ_BCEY01000006.1 and 1 other:
NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide
Lanthipeptides: GOZ53_RS01290_lanthipeptide
6
I L Q G T V G C-L A S Y A L G N Q G K I C T W S V E C Q N N C
36
+ + V C L S+A L G N G I C T W+ E C Q C
5
V A K S I V S C S L I S F A L G N D G W I C T W T A E C Q A T C
36
45.9%
NZ_VTZW01000015.1 and 1 other:
NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15850_lanthipeptide
Lanthipeptides: FZ103_RS15850_lanthipeptide
5
T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
+I V C L A S+A+G N+G C T +V E C Q+ C
6
S I A T A C V S C L A S W A V G N E G W A C T V T V E C Q D G C
37
45.0%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
2
W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
W T I L A S Y L G N G +C T +V E C Q C
5
W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C
39
44.7%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
7
L Q G T V G C L A-S Y A L G N Q G K I C T W S V E C Q N N C
36
L T+ C L A S +G++G++C T +V E C Q N N C
6
L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C
36
44.4%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
9
G T V G C L A-S Y A L G N Q G K I C T W S V E C Q N N C
36
T C+A S+ +G N G K+C T++V E C N N C
7
S T S T C I A V S H F V G N D G K V C T Y T V E C V N N C
35
44.4%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide
Lanthipeptides: GHI93_RS00065_lanthipeptide
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W ++ +V + A L G N G +C T W+ E C Q N C
1
G W T W N L V F S S V---V T L A L G N N G Y V C T W T H E C Q A N C
33
43.2%
NC_015215.1 and 5 others:
NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide
Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide
1
G W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36
G W T L S L G N G +C T W+ E C Q C
1
G W T G V A K S I T S C S L L S I G L G N D G W V C T W T A E C Q A T C
36

#### MIBiG 4.0 matches for LL065_RS24800

36.1%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
S Y A L G N Q G K I C T W S V E C Q N N C
36
S A L G N G C T + E C Q N C
9
S N A L G N N G G W C T L T K E C Q P N C
29
27.8%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
L G N Q G K I C T W S V E C Q N N C
36
L G N+G C T +V E C +C
10
L G N K G A Y C T L T V E C M P S C
27
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
26
C T W S V E C Q N N C
36
C T S E C Q N C
28
C T L S K E C Q P N C
38
with 3 more sequence matches
11.1%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
6
I L Q G T V G C L
14
++Q G+ C L
12
V I Q G S T I C L
20
11.1%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
1
G W V S T I
6
W S T I
14
A W A S T I
19
11.1%
BGC0002111.3 (EVG22_32245)and 1 other:
BGC0002111.3 (multiple genes) Lanthipeptide: andalusicin A or andalusicin B
Lanthipeptide: andalusicin A or andalusicin B
28
W S V E C Q N N C
36
W+ N N C
15
W A S T I S N N C
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.88 out of 26.85
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.14 out of 32.93
Confidence: medium
Additional weak hits (4):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.88 out of 27.55
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.21 out of 29.72
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 18.48 out of 29.51
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.66 out of 33.14
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LL065_RS24780 - Class I
  Cleavage pHMM score: -12.70
  RODEO score: 17
  Monoisotopic mass: 2690.5 Da
  Molecular weight: 2692.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2710.1 Da N = 1
    2728.1 Da N = 2
    2746.1 Da N = 3
    2764.1 Da N = 4
    2782.2 Da N = 5
    2800.2 Da N = 6
    2818.2 Da N = 7
    2836.2 Da N = 8
    2854.2 Da N = 9
LL065_RS24780 - Class II
  Cleavage pHMM score: -3.10
  RODEO score: 0
  Monoisotopic mass: 3052.7 Da
  Molecular weight: 3054.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3072.5 Da N = 1
    3090.5 Da N = 2
    3108.5 Da N = 3
    3126.6 Da N = 4
    3144.6 Da N = 5
    3162.6 Da N = 6
    3180.6 Da N = 7
    3198.6 Da N = 8
    3216.7 Da N = 9
    3234.7 Da N = 10
    3252.7 Da N = 11
LL065_RS24800 - Class II
  Cleavage pHMM score: -0.40
  RODEO score: 0
  Monoisotopic mass: 3694.8 Da
  Molecular weight: 3697.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3715.2 Da N = 1
    3733.2 Da N = 2
LL065_RS24720 - Class I
  Cleavage pHMM score: 1.90
  RODEO score: 21
  Monoisotopic mass: 2923.5 Da
  Molecular weight: 2925.4 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2943.4 Da N = 1
    2961.4 Da N = 2
    2979.4 Da N = 3
    2997.4 Da N = 4
    3015.5 Da N = 5
    3033.5 Da N = 6
    3051.5 Da N = 7
LL065_RS24780 - Class I
  Cleavage pHMM score: -12.70
  RODEO score: 17
  Monoisotopic mass: 2690.5 Da
  Molecular weight: 2692.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2710.1 Da N = 1
    2728.1 Da N = 2
    2746.1 Da N = 3
    2764.1 Da N = 4
    2782.2 Da N = 5
    2800.2 Da N = 6
    2818.2 Da N = 7
    2836.2 Da N = 8
    2854.2 Da N = 9
LL065_RS24780 - Class II
  Cleavage pHMM score: -3.10
  RODEO score: 0
  Monoisotopic mass: 3052.7 Da
  Molecular weight: 3054.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3072.5 Da N = 1
    3090.5 Da N = 2
    3108.5 Da N = 3
    3126.6 Da N = 4
    3144.6 Da N = 5
    3162.6 Da N = 6
    3180.6 Da N = 7
    3198.6 Da N = 8
    3216.7 Da N = 9
    3234.7 Da N = 10
    3252.7 Da N = 11
LL065_RS24800 - Class II
  Cleavage pHMM score: -0.40
  RODEO score: 0
  Monoisotopic mass: 3694.8 Da
  Molecular weight: 3697.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3715.2 Da N = 1
    3733.2 Da N = 2

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (150028...185282)
LL065_RS24725
  RRE type: Lanthipeptide_LanB_RRE
  Location: 156 - 240
  Score: 53.7

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response
RutR | Regulator of the pyrimidine and purine metabolism