LOCUS       NZ_CP113114            26008 bp    DNA     circular CON 14-JAN-2024
DEFINITION  Streptococcus pneumoniae strain NP1 chromosome, complete genome.
ACCESSION   NZ_CP113114
VERSION     NZ_CP113114.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2310574)
  AUTHORS   Sagar,V., Kaur,G. and Gupta,M.
  TITLE     Genome sequencing and assembly of Streptococcus pneumoniae strain
            NP1 isolated from nasopharynx
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2310574)
  AUTHORS   Sagar,V., Kaur,G. and Gupta,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2022) Community Medicine &SPH, Post Graduate
            Institute of Medical Education & Research, Chandigarh, Room No 529,
            Research Block B, PGIMER, Sector 12, Chandigarh, Chandigarh 160012,
            India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: MaSuRCA v. 3.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 356.0x
            Sequencing Technology :: Illumina Novoseq 600; Nanopore GridION X5
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/14/2024 02:39:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,409
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,154
            CDSs (with protein)               :: 2,154
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 181
            CDSs (without protein)            :: 181
            Pseudo Genes (ambiguous residues) :: 0 of 181
            Pseudo Genes (frameshifted)       :: 86 of 181
            Pseudo Genes (incomplete)         :: 87 of 181
            Pseudo Genes (internal stop)      :: 72 of 181
            Pseudo Genes (multiple problems)  :: 53 of 181
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:47:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1388671
            Orig. end                         :: 1414679
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP113114.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="7"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26008
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16008](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16008)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(186..199)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: strong, score: 23.52"
                     /tool="antismash"
     misc_feature    complement(1176..1193)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     gene            1507..2079
                     /locus_tag="OTU45_RS06960"
                     /old_locus_tag="OTU45_06960"
     CDS             1507..2079
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000066279.1"
                     /locus_tag="OTU45_RS06960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_06960"
                     /product="hypothetical protein"
                     /protein_id="WP_000182496.1"
                     /transl_table=11
                     /translation="MTNKKIRVFLSRPNPFTENQNLFIKELIKFLRRHNIECVTLQAAE
                     YTPYEVMNSLSEMIQRSYGIIIVAFGQTFISSGTRKMGAEDNPDFFASKETHLKNKWVT
                     SVYCHIEGILALTYNLPMLSIPQESLTEEGILKKGEYSITSPEFSLETKENILMYLQSE
                     GFQKSFHVWKNLLDDKYNFIKGGEINY"
     gene            complement(2076..2462)
                     /locus_tag="OTU45_RS06965"
                     /old_locus_tag="OTU45_06965"
     CDS             complement(2076..2462)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OTU45_RS06965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="OTU45_06965"
                     /product="hypothetical protein"
                     /protein_id="WP_050238940.1"
                     /transl_table=11
                     /translation="MSAINYYRLGMNFEDRNIYCARNYCANLLKIALVEKDVEVLKEFY
                     YTSVYTAKTILGSLEKIHRKSSEYDDIWFLSNQEDLMLISGLLSKPINDIEGLTERQKK
                     TINEGSIMLSEDLQRIKTAIVNGN"
     misc_feature    complement(2422..2435)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.52"
                     /tool="antismash"
     gene            complement(2566..3363)
                     /locus_tag="OTU45_RS06970"
                     /old_locus_tag="OTU45_06970"
     CDS             complement(2566..3363)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OTU45_RS06970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="OTU45_06970"
                     /product="hypothetical protein"
                     /protein_id="WP_267736585.1"
                     /transl_table=11
                     /translation="MTSCFVVMGFNTKKIPNTNIEVDLNQVYNNLIKPTILEKELVSVH
                     GKNHFRADEVFSTQSITKTFIEGILKADIVIADITTLNQNAIYELGLRHAMKPKSTIIL
                     CDHHTAKISFFDIAHLPQIRYDSDKLNEVDEVNKVKKLLSEYIDSAIKSDETFTDSPAF
                     ESALYRVIINDLIDKTEIQSEEALDKSIAELYDQATELKNSEKYPEAEEIFQQILESGY
                     IDEEILAGYLLSSYKKNESSLANLKMAQQNISKYIDINTTAKY"
     gene            3456..4352
                     /locus_tag="OTU45_RS06975"
                     /old_locus_tag="OTU45_06975"
     CDS             3456..4352
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384879.1"
                     /locus_tag="OTU45_RS06975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_06975"
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_000384886.1"
                     /transl_table=11
                     /translation="MDYKLISTYLDYCKTHKRLSSHTIRAYKNDLMQFYNSNYDNVESY
                     IEELTQSNIKTNTLRRKIACIKVFYNYLKYQHIIEENPFNQLRFQFRTEKILPKTIPYD
                     ILKNIFSYLEQRVVISKTDYQKQKAERNLLIISLLLSTGIRISELCHIHLKDINLSNKT
                     LHIIGKGKKERILFLGDQTTFNLLETYINKNGKESNDFLFPGKHSPKPLSEQSVRLILK
                     RIVEQNGLSKTITPHMFRHSFATMLLDNDVDIRYIQQILGHSSISITQIYTHVSHSKQK
                     EILSSFNPMSVIHSEIE"
     gene            complement(4730..5101)
                     /locus_tag="OTU45_RS06980"
                     /old_locus_tag="OTU45_06980"
     CDS             complement(4730..5101)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000540234.1"
                     /locus_tag="OTU45_RS06980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_06980"
                     /product="zeta toxin family protein"
                     /protein_id="WP_000540234.1"
                     /transl_table=11
                     /translation="MGYEVQLALIATKPKLSYLSTLIRYEKLYAINPDQARATPKEHHD
                     FIVNHLVDNTRQLEKLAIFERIQIYQRDRSCVYDSEEDKTSVATVLHDLLFGEWNQVEK
                     EMLKSGEGKLKDLTNRNGC"
     gene            <5135..5311
                     /locus_tag="OTU45_RS06985"
                     /old_locus_tag="OTU45_06985"
                     /pseudo=""
     CDS             <5135..5311
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000433508.1"
                     /locus_tag="OTU45_RS06985"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="OTU45_06985"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="INAL"
     gene            complement(5470..5697)
                     /locus_tag="OTU45_RS06990"
                     /old_locus_tag="OTU45_06990"
     CDS             complement(5470..5697)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000301903.1"
                     /locus_tag="OTU45_RS06990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_06990"
                     /product="hypothetical protein"
                     /protein_id="WP_000301903.1"
                     /transl_table=11
                     /translation="MAVVSLENNIKLYSSELFQALLKASNYKLDKRIAQTVAEGYARNL
                     DYSDPELMHVGVTSVANNLLTKIKQEYFNV"
     gene            complement(5688..6320)
                     /locus_tag="OTU45_RS06995"
                     /old_locus_tag="OTU45_06995"
     CDS             complement(5688..6320)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521733.1"
                     /locus_tag="OTU45_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_06995"
                     /product="DUF3990 domain-containing protein"
                     /protein_id="WP_000424175.1"
                     /transl_table=11
                     /translation="MELTTKQEKQLGQTQWFHATLLRHLESLKSGIDVKFNLGSELDFG
                     PGFYITPDFEQARKFINKQVEVLNRSSSNNNIFDSEEEVGIIVEFRISNFIEIFKNPDY
                     HCHYFAKHKKSESDLDFAEFVVQNRENPDELQHHFDFIYGVQTDDNPTQALARFRQNEI
                     TKEEMLAEFRKPYSFKQLSIHNQSFCDIMKIEKVYQSKTGEELQKWQ"
     gene            complement(6402..6677)
                     /locus_tag="OTU45_RS07000"
                     /old_locus_tag="OTU45_07000"
     CDS             complement(6402..6677)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000495439.1"
                     /locus_tag="OTU45_RS07000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07000"
                     /product="hypothetical protein"
                     /protein_id="WP_000495439.1"
                     /transl_table=11
                     /translation="MFTTFFKKNHDNSDVFKKLIHRLSDMSVQDLEKIDRLLDIIFTPD
                     QESEQVKTESIYREETLDDTLKEAKNQLHKEQLEKNLERFRKDGRK"
     misc_feature    complement(6653..6666)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 24.02"
                     /tool="antismash"
     gene            complement(6715..7098)
                     /locus_tag="OTU45_RS07005"
                     /old_locus_tag="OTU45_07005"
     CDS             complement(6715..7098)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159213.1"
                     /locus_tag="OTU45_RS07005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07005"
                     /product="DUF5945 family protein"
                     /protein_id="WP_267736587.1"
                     /transl_table=11
                     /translation="MTKDWNFNQPLESKSENQEDPDKIAALFGNHQGGNDVNYEAAFQK
                     RKQAPVTESNPNSKHKVTEVRTGKETDITTSYQQHLKRLIADNNSDIQSSQKKIEELHT
                     LIDTKNKDNKKLQSIYDAISDLH"
     gene            complement(7095..7328)
                     /locus_tag="OTU45_RS07010"
                     /old_locus_tag="OTU45_07010"
     CDS             complement(7095..7328)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152421.1"
                     /locus_tag="OTU45_RS07010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07010"
                     /product="DUF5965 family protein"
                     /protein_id="WP_024477680.1"
                     /transl_table=11
                     /translation="MTIIERLEEKVTRQENKVARETEKLAAYKEQLETAMFATFKRRQS
                     ISHMSFEEALDHAFGRERQFDDSEFRKDEMSE"
     gene            complement(7379..8479)
                     /locus_tag="OTU45_RS07015"
                     /old_locus_tag="OTU45_07015"
     CDS             complement(7379..8479)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590072.1"
                     /locus_tag="OTU45_RS07015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07015"
                     /product="DNA primase"
                     /protein_id="WP_267736588.1"
                     /transl_table=11
                     /translation="MEIEECKQISILDVANRLGISFKQVSSSVYEHPEHDSFRIFSTTN
                     TFKWFSRDIQGDVIDFVRLVQGISFKEALAFLSEEPFQKEAVQEKRERPFYYPLKRIED
                     SNCSLARYYLTECRGISEEIVQRMIQQGLIAQASWKTNETVEPVIVFKSFDHRHILQAA
                     SLQGIYKNPALSRERLKTILKGSHGHIGISFDIGKPNRLVFCESFIDLMSYYELHQQSL
                     SDVRLVSMEGLKRSVVAYQTLRLIAEENQRLEFLDTVIPSKLLPLINTIRDTTTRDTTT
                     YFDNHPDLLTLAVDCDDAGKDFSDKLSQEGFPVLLDLPNNEFGKEKIDWNDILREKKSD
                     LQLMIETAKETLRNQPVRQTSQCLEL"
     gene            complement(8489..9130)
                     /locus_tag="OTU45_RS07020"
                     /old_locus_tag="OTU45_07020"
     CDS             complement(8489..9130)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933080.1"
                     /locus_tag="OTU45_RS07020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07020"
                     /product="hypothetical protein"
                     /protein_id="WP_000933083.1"
                     /transl_table=11
                     /translation="MLNKVKTKALISVGAVAATSFILMMGYTAGQHSTAKQSRKEIELA
                     AAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELSSQN
                     DAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTNQTETRT
                     VKLSYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPSLPNTTTK"
     misc_feature    9180..9195
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            complement(9328..9990)
                     /locus_tag="OTU45_RS07025"
                     /old_locus_tag="OTU45_07025"
     CDS             complement(9328..9990)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669432.1"
                     /locus_tag="OTU45_RS07025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07025"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_088794854.1"
                     /transl_table=11
                     /translation="MKFTKIYLSVIFFLSLLGLTGCTYEKYDVKFLDSSYNRFDYKGEH
                     YGVTNQLISYEDIESKVSNHDDTYEISYDDSNNKIKNDLLEIGDLYQTKNREFAIKIDS
                     TFYKCRLLDNISKEELLKVSDLFNVRLVGGFAINEQEARELKIGEQSFTITEEIIPKEE
                     LSATVANLDNQVKSVTRLSGERESWKYGEICSLENQSIHEKVAVKLNGEYHLAFLRS"
     gene            complement(10001..11278)
                     /locus_tag="OTU45_RS07030"
                     /old_locus_tag="OTU45_07030"
     CDS             complement(10001..11278)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="OTU45_RS07030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07030"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_065428632.1"
                     /sec_met_domain="LANC_like (E-value: 1.5e-55, bitscore:
                     185.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMYDESKIIELLQRRIIEEWDIKIKSDTIYNSYENYSLAAGLPG
                     VILLLSEINYDEYKDQIDNYLIYIVKILSNNGIVSSSLYSGAAGLALSLLHLANKDKKY
                     SDLINSIDNYICYSIEDTIHQIDADTLSPLNYDIIEGISGILVYLLIKDDEKFNDIISD
                     IINKLIDLFVNNHGLPPYYVKSQNQLSIIESEIFPKGCLNLGVAHGLAGVGIMVAIACI
                     KGFTNSKTKKFLKNIIKIYDRLEIADGTNQYKWKSAINMDEYSKGSDLDNKEYFRDAWC
                     YGSPGISLLYLYVGIFLKDQKLVEKSKNILIASLECPVGVQSSILCHGYSGLYEIGFLY
                     KQIFKEEPWDRYLSIIKEKILSSFTISKKFGFEEDNYYSDGNEGSVKFLDGSLGIVLTL
                     LHIQNKYVKTYWREALLIFDNLTIEN"
     gene            complement(11265..13040)
                     /locus_tag="OTU45_RS07035"
                     /old_locus_tag="OTU45_07035"
     CDS             complement(11265..13040)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015425980.1"
                     /locus_tag="OTU45_RS07035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07035"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088794855.1"
                     /transl_table=11
                     /translation="MPEFTHSDFFRTICGIPSSLRMIYKVDKKYISGLIVLTLINGVIP
                     VISLLISQELINTIISGGQLSYIISVYVVIQICSAVVTQLNSYFGEKIGFLLSYNLSTQ
                     LMERVAMLKLPDFEQSTIYNLVEKLNQGVSYKPLQLLNAILSLLSSTVSLFLSLYYIGS
                     WRLEFALLLLIIPILSLVLFIKVGQMEFLLQWKRADKERKVWYLNYLLTHDFSFKEIKL
                     NGISDYLINEYKQLKEQFILQDLSISRKKISFNLLLGGVLNIIGLVGIVFMVLLIRQGK
                     LLLGNMVSLIQAFGRVDTYSQDIIHNIYIINNTNLYMEQLLMFLDDSSQSDKQCNSVSK
                     VDISEVEFRDVSYIYNGNNTPAVKSLNLKLLKNELVAIIGKNGSGKSTLVKLLAGLYIP
                     SKGVILYDNLDFKDNETFFQNNISALFQDFVKYELSLRENICLGDLSKMDIEESINLIS
                     HDFNIDFIKRGGRIDLDTQLGSWFNNGRQLSGGQWQKIALLRTFFKEAPIVILDEPSSA
                     LDPISEKQLFDTFKKNAKDKISIFISHNIKSAQKADKIVVLDNGEVVGVGTHVELLHKC
                     PEYQEIYYSEEYGNV"
     misc_feature    13017..13030
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            complement(13045..16008)
                     /locus_tag="OTU45_RS07040"
                     /old_locus_tag="OTU45_07040"
     CDS             complement(13045..16008)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="OTU45_RS07040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07040"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_088794856.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.6e-95, bitscore:
                     315.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1e-09,
                     bitscore: 36.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.6e-22, bitscore:
                     77.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANKFEAQDFLIRNSIRAGDIDIFDTINDFFDFIRKDSVFLEQLQ
                     VASPLVYQSLLKYYQNKLTQDKQISQLFISTYKYYKRSMNRATPFGLFSEISIGKFASK
                     SSLSLENSSYKSIKPDSDWYMKFIDMLEMDNYPILSFKVNRAVYINGNRAVQLYSLKKN
                     EEEVSIKNTKAYELIVSLCSDSFISFDNLHSTLMQKYGVEKKEIVTNYIIELIKNNYLL
                     SELRFKNKENNDWDFLLATVSKLGCNELLKALKQIVYLVSRYEKSDVGEGNEILSNICA
                     KMCDICYSSNYVQVDLFNKSQITLDDQYKNTLEECAQFIEKVNMDDKKLYIDHYKDKFL
                     EKYGLNQEVPIIEMMDSNFGIGAPFDYTHPKNEIIETEPKVKYYSDNLEKVLLDLYVYA
                     VRTDTNIDLQKLEGLFLKENKKYEVGGMELFFSVTKTLETDTVQFHLSNLVGTSNLGAS
                     SGRFSQFSQSFNEYHQKMVNYCNNWNNNQGIVTCEIEFMPETFRDCNVMRNNTVRNYTL
                     SLFLNSSKNEIKLDNIYIGIGEGGKFYAREKLTGELIKFYVTNMYNRMLFCNEVRFLCD
                     ISEDYFGNIPWDLVYAKFNFVPRLCYRNIVISPKTWKIYKNELNEITDKNICSYLKSKN
                     IPHKFNVVNIDNKINIDLTKHLDILLLTDMFSKAKKNNFEFMIIQEIIDDDGVFLKNSK
                     SVTSEIVIPFKKEREFYNSYGNKSNMQRVERLSREKLPLTDWIYLKLYIPNNRQDEFIT
                     DYLRNIKLLIDKYQGGLFYLRYIEKHSQIRLRIKADNNLEVFQTIQGELKKAITNNVMV
                     NYEISTYDREIERYGGKRTLEKIENIFCLDSYLNMEIINQNKKGNISLDIKYISVLIPY
                     FYLEYLFDYVTKVEFLEFVSPRTDKFNINKERKKYQEAIERIDELHVLDSENVQNLKNE
                     LIELKEILKEYSKEQRFSIVDSIIHVHNNRLVGIDREREREIYYILRSIIISEQYRR"
     aSDomain        complement(15331..15585)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_OTU45_RS07040_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.20E-11"
                     /identifier="RREFam001.1"
                     /label="OTU45_RS07040"
                     /locus_tag="OTU45_RS07040"
                     /protein_end="226"
                     /protein_start="141"
                     /score="36.1"
                     /tool="antismash"
                     /translation="KVNRAVYINGNRAVQLYSLKKNEEEVSIKNTKAYELIVSLCSDSF
                     ISFDNLHSTLMQKYGVEKKEIVTNYIIELIKNNYLLSELR"
     gene            complement(16256..16432)
                     /locus_tag="OTU45_RS07045"
                     /old_locus_tag="OTU45_07045"
     CDS             complement(16256..16432)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="OTU45_RS07045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07045"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_088777683.1"
                     /sec_met_domain="TIGR03731 (E-value: 5.1e-20, bitscore:
                     68.4, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 3.4e-05, bitscore:
                     20.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNDDFNLDLVKVTKDNSGASPRITSVSLCTPGCVTGVLMCPGNT
                     ISCNGHCSIHITG"
     CDS_motif       complement(16364..16432)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSNDDFNLDLVKVTKDNSGASPR"
                     /locus_tag="OTU45_RS07045_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16256..16363)
                     /prepeptide="core"
                     /locus_tag="OTU45_RS07045_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="26.60"
                     /molecular_weight="3314.9"
                     /monoisotopic_mass="3312.6"
                     /core_sequence="ITSVSLCTPGCVTGVLMCPGNTISCNGHCSIHITG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNDDFNLDLVKVTKDNSGASPR"
                     /leader_location="[16363:16432](-)"
                     /alternative_weights="3332.9"
                     /alternative_weights="3350.9"
                     /alternative_weights="3368.9"
                     /alternative_weights="3387.0"
     misc_feature    16526..16537
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.77"
                     /tool="antismash"
     gene            16690..>17299
                     /locus_tag="OTU45_RS07050"
                     /old_locus_tag="OTU45_07050"
                     /pseudo=""
     CDS             16690..>17299
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558050.1"
                     /locus_tag="OTU45_RS07050"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="OTU45_07050"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MISVKKTPYKI"
     gene            complement(17721..18152)
                     /locus_tag="OTU45_RS07055"
                     /old_locus_tag="OTU45_07055"
     CDS             complement(17721..18152)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OTU45_RS07055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="OTU45_07055"
                     /product="hypothetical protein"
                     /protein_id="WP_267736589.1"
                     /transl_table=11
                     /translation="MISKKDVIKVLMPFPDVNSDLALIRHYYICHSNVQNNKILFKCQT
                     HKATMIAKCGGNKKFRESYFLIRAGDKVPFVRNIVVDKKQIFKLNNTMIPKLYLSPEKP
                     SDIPEQIYENIVKEIITDSKPAIRTINKEKFIKLNTECK"
     gene            complement(18145..18789)
                     /locus_tag="OTU45_RS07060"
                     /old_locus_tag="OTU45_07060"
     CDS             complement(18145..18789)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OTU45_RS07060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="OTU45_07060"
                     /product="hypothetical protein"
                     /protein_id="WP_267736590.1"
                     /transl_table=11
                     /translation="MVLNTSKSMLDKIAWLNKQEDITKFSKLQLQKFLFLYEMFQFVEK
                     KDSDFTYLKAYKNGPVFSNFYGDITYREAKVQDYLKQKQCDFDIDESNARISQFIINTL
                     TDSELSDLTHQFKMWSTHKEEIDAGKKQIPMSEKDITDDDIEILDLLKSSEPDYDYEIL
                     RIDQKNFVFSKEDFMNLNEEHLELLDSLSTNEELLNPVYVEVESSGRLVID"
     gene            complement(19036..19713)
                     /locus_tag="OTU45_RS07065"
                     /old_locus_tag="OTU45_07065"
     CDS             complement(19036..19713)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615439.1"
                     /locus_tag="OTU45_RS07065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07065"
                     /product="hypothetical protein"
                     /protein_id="WP_000615442.1"
                     /transl_table=11
                     /translation="MIQLLKSEMIKFKGSYQLYIILILSTIQLLTIPIYILSVNNTIVL
                     ENIIFLPMLGYCMITTIITLLVSEQEINANNYQNIKGSRNTASIWGAKIFVLDLLLSLL
                     TIPLWVVVGIELEHFSYYFYVGIVSWLLLILLNHFHMLLTLFIAKGGNLLIAVVESLFI
                     LFATNKVFLNIFWIPVILPVNIILENNFRSTTNLLALTFYVVLLFVANLVIVTRKGAQS
                     YTK"
     gene            complement(19691..20431)
                     /locus_tag="OTU45_RS07070"
                     /old_locus_tag="OTU45_07070"
     CDS             complement(19691..20431)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590350.1"
                     /locus_tag="OTU45_RS07070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07070"
                     /product="hypothetical protein"
                     /protein_id="WP_000590350.1"
                     /transl_table=11
                     /translation="MIKIFKSEWLKQRKNTSKKFLIIAPGLSILIAVLLVGPSILESFS
                     IYWWEAVFLYTLIGLLFLYDYKAEEAAGNFQNIYFRNDSIKIYIVKILLKLKDLLISNV
                     WFLAILLFTSNFLYGDLISLNIIGDLICLVLISITSIWVLPLLYLFSKRINPYILVSIN
                     SLICFLVAPFIAQSSFWFFFPFTYHYKIAYSLMYIKPSGDLDLTNHVTDVKMVVFTVFL
                     SLILFIVSLLMLNWRLSNDPIAKK"
     gene            complement(20428..21114)
                     /locus_tag="OTU45_RS07075"
                     /old_locus_tag="OTU45_07075"
     CDS             complement(20428..21114)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025882.1"
                     /locus_tag="OTU45_RS07075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07075"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001025883.1"
                     /transl_table=11
                     /translation="MNIQVQKLRKSYKDREVLKNISFEIKEGSICGLLGINGAGKSTIM
                     KIIFGLENADSGTVIFNGKKNAGIYEIGALIETPAIYMNLSAYDNLKTRALLYDISDER
                     INEVLNLIGLSNTGKKKAGSFSLGMKQRLGLGMAIITSPDLLILDEPTNGLDPDGIKEL
                     LNLMISLKKSGMTILLSSHQLYEVSKVADKVVILHDGQIFYDGSNVQSDDLESLFIRIV
                     HGGDAI"
     gene            complement(21285..22625)
                     /locus_tag="OTU45_RS07080"
                     /old_locus_tag="OTU45_07080"
     CDS             complement(21285..22625)
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977994.1"
                     /locus_tag="OTU45_RS07080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07080"
                     /product="sensor histidine kinase"
                     /protein_id="WP_088794857.1"
                     /transl_table=11
                     /translation="MSKKSTIRGRIIRTVLELVTGTLLSILLFFIFTYLLVFTGQLNVY
                     GSKMEISVSDSSNLSDVVQAMNNSIFDYVVFNRKTGTIEEGNYQKKDLPAYREVFAKNE
                     SISNDAVYYGYYANSEIVLTVRQPMIPEFVNPNLRHFSFNLFSYLFFFVIETILLIWSL
                     TRLIKEFSNNFLLIQKKTLNMGQLTFKDKNIPAQIQEFDEILSVLYQKDDELTNLLKSE
                     RREKEDLSFQVGALAHDVKTPLTVLKGNLELLELTNLTVQQKEYTQSMNNSIVVFERYF
                     SSMIDYSRLLIEDKDYGEQIHLSEFLSELSVEAKSVMNNAKVDFKIINTTKLIFFKGNR
                     FNLNRALINILANAARYCSGEKKVTLTIIEETEYINFVVWNNGLPFTEQSLLNADKLFY
                     TENKGRNNKHYGLGLAFAKQVATRHLGELFLSNPDRGGAQVTLLIKK"
     gene            complement(22618..23301)
                     /locus_tag="OTU45_RS07085"
                     /old_locus_tag="OTU45_07085"
     CDS             complement(22618..23301)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276749.1"
                     /locus_tag="OTU45_RS07085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07085"
                     /product="response regulator transcription factor"
                     /protein_id="WP_000276746.1"
                     /transl_table=11
                     /translation="MYKILVVDDDFEILKLMRTILEMKNYQVTTYQEVTVPININNFKG
                     FDLILLDVMMPNIDGMQICKQIRNKVRSPIIFVSAKDTEDDIVSGLNLGGDDYITKPFS
                     INQLIAKVAANLKREERYKQGELSNQIVRELSPITIYLQEKIVCINGDSLAFTSREYDI
                     IELLSSNPRKIFTVQDIYENVYDDDAETLFRSISEYIYQIRLKFSSYGINPIKTVRGMG
                     YKWHE"
     gene            complement(23431..24798)
                     /locus_tag="OTU45_RS07090"
                     /old_locus_tag="OTU45_07090"
     CDS             complement(23431..24798)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001080213.1"
                     /locus_tag="OTU45_RS07090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07090"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_049532570.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.1e-37, bitscore:
                     125.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKFLLSVGVLFPLFFSVHGVQATAGSDFKYNILLKETETVDTI
                     QQKFIKQGMQIIDIIPEINLITVSTGKSKEEIKKENNNSIKEIVIDGMMNVKPNVTYLY
                     GESVITTNNMNFWDYQWDMQKSIGTGRKFSHKSTGEATIGVIDSGVTYDNPEVSSNIIS
                     VKNFTADLETGLIDNQNILDKTGHGTSVVGQISSNGNYLGIAPGMKVRMYRVFDKGNAQ
                     DQWILKAIIQAAKDDVDVINLSLGEYLLKNSTIEDDQTALINIYQRAINYAYSQGSIIV
                     ASVGDEGLDLNNQESLKHYLGELKGKDYSHIDGKVMDIPAGLDNVVTVGSVNDNDFVSS
                     FSNKGNNVIDIYATGGGSHKLATVGYEQWANDKTFEKEWVIVPTLEGKYTYAYGTSIST
                     PKVSAALGLIIEKYHLKDQPDEVIKLLYDNCCIGNDIDGTQIRLLNITNFVQDSVK"
     misc_feature    24940..24953
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.52"
                     /tool="antismash"
     gene            complement(24972..25259)
                     /locus_tag="OTU45_RS07095"
                     /old_locus_tag="OTU45_07095"
     CDS             complement(24972..25259)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000998897.1"
                     /locus_tag="OTU45_RS07095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07095"
                     /product="DUF5966 family protein"
                     /protein_id="WP_180700716.1"
                     /transl_table=11
                     /translation="MNDLLLIPVIFLAVGGILILLWRLFLIASGLFLIGFVSFLIFVEG
                     YGIYLFFTETELYTADLAQNGLFGFTTFFIIFNLVLLALACWTGYKWKKG"
     gene            complement(25273..25557)
                     /locus_tag="OTU45_RS07100"
                     /old_locus_tag="OTU45_07100"
     CDS             complement(25273..25557)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263534.1"
                     /locus_tag="OTU45_RS07100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_07100"
                     /product="DUF5962 family protein"
                     /protein_id="WP_088794862.1"
                     /transl_table=11
                     /translation="MMEDTYYQLEEALVQGFQTPEEYQAYKELKEHYEEVTGDYSFSIQ
                     ELTSQLEIALQNHRGVDFEDYEKEEYLGLVQKLEEFDSSLATHYRQLID"
ORIGIN
        1 aaaaaataga tctcagtcca tctcctagat ctgaaactgt aaatgcttct tcagtggttg
       61 ttggtgaaaa ttttaaggca atctgtctaa gtgctgccgc catctcagaa gaattaataa
      121 tcaactctgc ttgagaaaaa cggttatctt catgatataa ttcccatgac ttctgaatct
      181 cattgttgat ctgagtcaat gctccatttt cagataaaaa ggtgttattc aactcatcaa
      241 ttttatctgt aatttcattt atctcatctt cggtccaatt tatactattt accaacctac
      301 ttaacatact acctgaagca ttacccaact ccttctcagg cgttcttgaa gcaggtacat
      361 aaagtaccct aattttatcc aaatcctttc taggagcacg atgtttgtct tcatctctaa
      421 tagtatcttc atcagatgaa atataataga attgagtatc aatacttcct tcaactgttc
      481 catcatcttc ccaagaagat tctaacctga ttcgtagaaa tggtttggca ccatctttag
      541 aaactgtaaa gtgttcgaaa aacgatggaa ttgcttgact atagggagtt ccatcaagtt
      601 catcaaactc aaaaatagtt tctataaaga ggtttctagt attttctccg ggccttgaac
      661 cttttggaag gtgaaaatca ctttttttta ttattctatc attttgtttg tccgaaaaca
      721 gcttactcaa tgcttgtaat acagttgttt ttcccgaact attattccca atcagtacag
      781 tttgattatt taattcaata atttgacttt caccgaatga tctaaaatta ttaataatta
      841 cttttgttaa cttcatttct tatctccatt acctgaaact aattcacaca accattcctg
      901 tcccaccttc tacatctctt cctcaaccct actctattac ccaaaaaggc attattgaag
      961 agtgacagaa gcttaacctt gatctatttt tgaaacatag acacatcttc tatgaattcc
     1021 tagcaaatag ttgaaatagt acttgttccg tttttataac agctaagggc tattgcgtaa
     1081 aatttataca attcgagcaa atctgttttt gtcaggccat gtgtctttcg tagaatttta
     1141 tattgttacc aattatagca tgctcttttt acttgataac actattataa catttaaaaa
     1201 taaaaacaga ttctgaacta atagaaaata taattctaaa attagaattt ttcttgataa
     1261 tcatataaaa tgctacattt ctaataaact tgtacttatt tccttcaaac tacacaattc
     1321 tcgagttgtt gtaagtttgt aattgactca aaagtattag atataatttc aaaacagtat
     1381 tttactttat agttgaccaa taacatttaa ttctaactaa aaaaaccatt atacaaatca
     1441 agctactaaa aatgacttta tggtatacta gtgataataa attgttatcg gtaggagata
     1501 gcgaatatga caaataaaaa aataagagta tttttaagca gacctaatcc atttacagag
     1561 aatcaaaatt tatttattaa agaattgatt aaatttttaa gacgacacaa tattgaatgt
     1621 gtaacattac aagctgctga gtatactcct tacgaagtca tgaattcgtt gagtgagatg
     1681 atacaaagga gttacggaat tataattgtt gcatttggtc agacatttat ttctagtgga
     1741 accagaaaaa tgggagctga ggataatcca gacttctttg catccaaaga gacccactta
     1801 aagaataagt gggttacaag tgtttattgt catattgaag ggattttagc gttaacttat
     1861 aatcttccaa tgctatctat tcctcaagaa agtttaactg aagaagggat tttaaagaag
     1921 ggagaatatt ctataacatc acctgaattc tcattagaaa caaaagaaaa tatattaatg
     1981 tacttgcaat cagaagggtt tcaaaaaagt tttcatgtat ggaaaaacct tcttgatgat
     2041 aagtataact ttatcaaagg aggggaaata aactattaat taccatttac aattgcagtt
     2101 ttaatcctct ggagatcctc acttaacata atactacctt cattaattgt ttttttctgt
     2161 cgttcagtta aaccctcaat atcattaata ggttttgaaa gaaggcctga aatcagcatt
     2221 agatcctctt gattggaaag aaaccaaatg tcgtcatatt cactagattt acgatgtatt
     2281 ttttctaaag atcctaaaat agtttttgct gtataaacag atgtatagta gaactccttt
     2341 aaaacttcaa catctttctc aactaaggct atttttaaca ggttagcaca gtaattcctt
     2401 gcacaataaa tatttctatc ttcaaaattc atgcctaacc tatagtaatt aattgcagac
     2461 attaagtcac tcctattctt tgtaatataa aatatacgta agaaaatagc tccataaata
     2521 cctaataact tatgatatgt tgtggtgttt atatctatat atttactaat attttgctgt
     2581 ggtgtttata tctatatatt tactaatatt ttgctgtgcc atttttaaat ttgctagcga
     2641 agattcattt ttcttatagg atgatagtaa atagcctgcc aaaatttctt catcaatata
     2701 tccactttct aaaatttgct gaaatatttc ttctgcctca ggatactttt ctgaattctt
     2761 gagttccgtg gcttgatcat aaagttcagc tattgacttg tctaatgctt cttcactttg
     2821 aatttcagtt ttatcgatta aatcgttaat tattacacgg tatagagcag attcaaaggc
     2881 tggactatca gtaaatgtct catctgactt tatagcggaa tcaatatatt cagaaagcag
     2941 ttttttcacc ttgttaactt catccacttc gtttaactta tcagaatcat atctgatttg
     3001 aggtaagtgt gcaatatcaa aaaagctaat cttagctgtg tgatgatcac acagtataat
     3061 ggttgatttg ggtttcatag catgacgtag acctaactca tagatagcat tttggtttaa
     3121 agtagtaata tctgcaatta caatatctgc ttttaatata ccttcgataa atgttttcgt
     3181 tatactctgt gtactgaaaa cttcatcagc tctaaagtgg tttttaccat gaacagaaac
     3241 taattctttt tctaaaattg ttggcttaat tagattatta tagacttgat tcaagtccac
     3301 ttctatattt gtattaggaa tttttttagt attaaacccc ataactacaa aacaactggt
     3361 catttctcaa ctttctcccg ataacaattt attatcacta tacaaagcac tcaaataggt
     3421 ttataatagc atgattattg ataaaggaga tttttatgga ttataagctt atttctactt
     3481 acttagatta ttgcaaaact cataagcgtt tgagttcaca cacgattcga gcttataaga
     3541 atgatcttat gcaattttat aattcaaact atgataatgt cgaatcctat atcgaagagt
     3601 tgacacaatc taacataaaa acgaatacat taagaagaaa aattgcttgt ataaaggtgt
     3661 tttataacta tctaaaatac cagcacataa ttgaagagaa tcccttcaat caattacgct
     3721 ttcaatttag aactgaaaaa atattgccta aaacgattcc gtatgatatt ctgaaaaata
     3781 ttttttcata tttagagcag agagtagtta tatctaaaac tgactatcaa aaacaaaaag
     3841 ctgaaagaaa tctactaatt atttccctat tactttcaac aggtatcaga atttctgaac
     3901 tttgtcacat tcatctcaaa gatattaatc tttccaataa gacactccat attataggaa
     3961 aaggtaagaa agagcgtatc ctatttttag gagatcaaac aaccttcaat ttattagaaa
     4021 catatataaa taaaaacgga aaggaatcta atgatttcct attcccagga aaacattcgc
     4081 ctaaaccatt gtcagagcaa agtgtacgtt taattttaaa gagaatcgtt gaacaaaatg
     4141 gcttatctaa aactattaca ccacatatgt ttagacatag ctttgcaaca atgcttctag
     4201 ataatgatgt agatattcga tatattcaac aaattcttgg acacagttct atatcaatca
     4261 cacaaatcta tactcacgta tctcattcaa aacaaaaaga aatacttagt tctttcaatc
     4321 ctatgtcagt gattcattct gaaatcgagt aagagacatt tccgaaggtt acagtttact
     4381 tcatcttaaa ttaatgtttg tagttgactt tagttaatag attttatact caacaaaagc
     4441 aaaaagcatg caaaactcca ctttgaatca gcatttatac tatattccgt attaagaact
     4501 ccataattgt ttttctaaaa tataactttc aagtatcctt aaatataatg aaaagagatg
     4561 ggcaaaatct caattcctga agaaaatgga gtaaatcttc ccacaagaaa acgcataatt
     4621 tcaagttttt caacacctga gactatgcgt tttttgcttc taaaaaagtt tcgcccacct
     4681 taaacaacta acaaaagtta taagtagact atattttaaa actcaagatc taacaaccat
     4741 ttcgattagt taaatctttc aattttcctt ctcctgattt aagcatctct ttctcaactt
     4801 gattccattc gccaaatagt aaatcatgaa gaacggttgc tactgaagtt ttatcttctt
     4861 ctgaatcgta tacacaactt ctatctcgtt ggtaaatttg aattctttca aagatagcta
     4921 gtttttccaa ttgtcttgta ttatcaacta gatgatttac aatgaaatca tgatgttctt
     4981 ttggagttgc gcgtgcttga tctggattga tagcatacag tttttcataa cggataaggg
     5041 tgctcagata ggacagctta ggctttgtcg caatcaaagc taattgtact tcatatccca
     5101 tacttttcaa gagttgtgct gtttcctttg gaacatcaac gccctttaac taccctattc
     5161 taacgccaaa ttggaagcga ctaataatct cattaaactc atcaaacgaa atgcctttgg
     5221 ttttcgaaac tttgaaaact tcaaaaaacg gatttttatc gctctgaaca tcaaaaaaga
     5281 aaggacgaaa tgtgtccttt caagatctta gcttttcttc aacccactgc agttgacaaa
     5341 gagccgtaac atttagaaaa aagaaatgca ccatttttgg tgcgttactt cttgtttttc
     5401 tagcctaaac tttacttcta aaaaagccac cttaaagagt aattcctttt tcggtggctt
     5461 tttaaaatac tatacattaa aatactcttg tttaattttt gtaagcagat tgttagcaac
     5521 cgaagttaca ccaacatgca tcagttcagg atcagaataa tctagattac gagcatagcc
     5581 ttctgcaaca gtctgagcaa tacgcttatc caatttataa ttagaggctt ttaatagtgc
     5641 ttgaaataat tctgaactat atagtttaat attattttcc aatgatacta ctgccatttt
     5701 tgtaactcct ctcctgtttt tgattgataa accttctcta ttttcattat atcacaaaaa
     5761 gattggttgt ggatggataa ttgtttaaaa gaatatggtt ttctaaactc agcaagcatt
     5821 tcttcttttg taatttcatt ctgacgaaaa cgagctaaag cttgggttgg attgtcatca
     5881 gtctgaacac catagataaa atcaaaatgg tgttgtaatt catctggatt ttcccgattt
     5941 tgaacgacaa attcagcaaa atctaaatct gactctgact ttttatgttt tgcaaaatag
     6001 tgacaatgat agtcagggtt cttaaaaatt tctataaaat ttgaaatacg aaattctact
     6061 ataattccta cttcttcttc tgagtcaaaa atattattat tagagctgct tcgatttaat
     6121 acttcaactt gcttgttaat aaattttcta gcttgttcaa agtcaggcgt gatatagaaa
     6181 ccaggaccaa aatctagctc acttcctaaa ttaaatttaa catctatacc actttttaag
     6241 gattctaaat gtctcaataa tgtagcatga aaccactgcg tctgacctag ttgcttttcc
     6301 tgcttggtag tcaactccaa aatatttact tccttctcta gtctatacta aaagtataac
     6361 acaagacttt attcaagtaa aagaaaattg tataaaacta ttcacttcct tccgtctttc
     6421 ctaaatctct ctaaattctt ctccaattgt tccttatgaa gttgattctt agcttccttt
     6481 aatgtgtcgt ccaaagtttc ttccctataa attgattctg tttttacttg ttctgattct
     6541 tgatctggag tgaaaatgat atctaacagt cggtctattt tttcaagatc ttggacagac
     6601 atatcagata gtctatgaat cagcttttta aatacatcac tattgtcgtg atttttctta
     6661 aaaaatgttg taaacatcta taacctctca aaaaaagcag cctatcagga ctgcttagtg
     6721 taaatccgaa atcgcatcat aaattgactg caatttctta ttatctttat tctttgtgtc
     6781 aattaacgta tgtagctctt caattttctt ttgactgctt tgaatatcgc tattgttatc
     6841 tgcaatcagt cttttaagat gttgctgata acttgtagtg atatctgtct cttttcctgt
     6901 tctaacctct gtaactttgt gtttagaatt aggatttgat tctgtcacag gtgcttgttt
     6961 tctcttttga aaagctgctt cataatttac atcattacct ccttgatgat ttccaaataa
     7021 ggccgcaatt ttatctggat cttcttgatt ttctgattta ctttctaatg gttgattaaa
     7081 attccaatct tttgtcattc actcatttca tcctttctaa attcagaatc atcgaattgt
     7141 ctttctctac cgaaggcatg gtcaagagct tcttcaaaac tcatgtgact aatgctttga
     7201 cgccttttga acgtcgcaaa catcgctgtc tccagttgct ctttgtaagc agcaagtttt
     7261 tctgtctctc ttgctacctt gttttcttgc ctagtgacct tttcttctag gcgttcaata
     7321 atggtcatat acgaacctcc ttcattttaa tattagctaa aacatcttga ttttgttatc
     7381 acaattctaa acattgagag gtttgtctta ctggttgatt cctcaatgtc tcttttgcag
     7441 tctcgatcat caattgtaaa tctgatttct tttctcgaag aatatcgttc cagtctattt
     7501 tttctttccc aaattcatta ttaggtaaat ccagtaaaac aggaaatcct tcttgagata
     7561 acttatcaga aaaatctttt cctgcatcat cacaatctac cgcaagtgtc aataaatcag
     7621 gatgattatc gaaataggta gtggtatcac gagtagtggt atcacgaatt gtattgatca
     7681 aaggtaataa ctttgaaggt attactgtat ctaaaaattc caacctctga ttttcttcag
     7741 ctatcagtcg taaagtttga taagcgacaa cagacctttt taatccctcc atagatacca
     7801 agcgaacatc tgataggctt tgttgatgaa gttcgtaata gctcatcaag tcgataaacg
     7861 attcacaaaa gaccagtcta tttggtttac caatgtcaaa ggatattcca atatgtccat
     7921 ggcttccttt tagaatcgtt tttaacctct ctctagaaag agcgggattc ttataaatcc
     7981 cttgtaaact tgctgcctgt agtatgtgac gatgatcaaa gcttttaaaa acaataacag
     8041 gttcaactgt ttcatttgtt ttccagctgg cttgtgctat taaaccttgt tgaatcatcc
     8101 tttgtacgat ttcttctgaa attcctctac attctgttaa gtaatatctg gccagactac
     8161 agttagaatc ttctattctc tttaaaggat aataaaatgg tctctctctt ttttcttgaa
     8221 cagcttcttt ttgaaaaggt tcttcagaaa gaaaggctag agcttcttta aaggaaattc
     8281 cctgaacaag tcgaacaaaa tcaatgacat caccttgaat atctcttgaa aaccatttaa
     8341 aagtattggt agttgaaaaa atccgaaatg aatcgtgttc aggatgttca tagacactgc
     8401 tcgaaacttg tttaaaggag atacctaaac gattggctac atcaagaatt gaaatttgct
     8461 tacattcttc tatttccatg caatatcatc attttgttgt agtatttggt agtgatggaa
     8521 cagatgagga ttcttccaaa gttttgggag tggccttatc caaatcatct aacccagatt
     8581 tccaaacctg tacttgatta accaataact taccaggtag tttcgaataa gacaacttaa
     8641 ccgttctggt ttctgtctga ttggtctttg attggttggc attctttaaa tcggatacat
     8701 aggttacatt ataagagacc atggcaatag cttgattcgt agtctgattg acaaaaatat
     8761 cagctttttc aaaatgataa tccaaaatat aatccttata cacttggttc atggcatcat
     8821 tttgacttga taattcttga gaataagctg attcagtcat ataaggttga atacgtgtat
     8881 tattttcccc tagtttttct ttcgtatagt actgtgtcaa aaattctttt acagtatccg
     8941 atgacaaaat acttgcttta tcttctgctt gtttatcttc cacaagttta gctgcagcca
     9001 attcaatctc tttgcgactt tgtttagcag tagaatgttg accagcagta tatcccatca
     9061 tgagaataaa gctagttgca gccactgctc caacactaat taaggcttta gttttgactt
     9121 tatttaacat cttagacctt ctttctataa aaactaggtc aagaataaca aaaagaactt
     9181 gtaagtttta tcacaaggaa aaagtatggt ctaaaactca atttcagtag aaaattaaga
     9241 aaatcttccc acaataaaac gcatagtatc tagttttttc aattcctgac actatgcgct
     9301 ttttctttta aagacttttt gcccagttca acttcttaag aaggccaaat gatattctcc
     9361 attcaattta actgctactt tctcgtggat agactgattt tctaaagaac atatttctcc
     9421 atatttccaa ctttcacgct cccctgataa tctagtgact gacttcactt gattatctaa
     9481 gttagcaact gtagcactaa gctcttcttt tggaataatt tcttcagtaa ttgtaaatga
     9541 ttgttcccct atcttcaact ctctggcttc ttgctcattg atagcaaatc ctcctactaa
     9601 gcgaacatta aataagtcag aaacttttag tagttcttct ttagaaatat tatcaagtag
     9661 tctacattta tagaaagtac tatcaatttt tatggcaaat tctctattct tggtctgata
     9721 taagtcacca atctccaaca aatcattctt tattttatta ttggaatcat cgtaagatat
     9781 ttcataagta tcatcatgat tgcttacttt actttcaata tcttcatatg aaattaattg
     9841 attagttaca ccataatgct ctcctttata atcgaatcga ttataacttg agtcaagaaa
     9901 tttaacatca tacttctcat atgtacatcc agtcaatcca agtaaactta agaaaaaaat
     9961 tactgaaaga tagatctttg tgaatttcat agttctcctc ctaattttct atagttaaat
    10021 tatcaaaaat taataacgct tctctccaat atgtcttgac atacttattt tggatatgaa
    10081 gtaaagtcaa aacaattccc aaacttccat ccaaaaattt aacacttcct tcatttccat
    10141 cagaatagta gttatcttcc tcaaaaccaa acttttttga tatagtaaaa ctacttaata
    10201 ttttttcttt aattatggac aaatacctat cccaaggttc ttctttgaaa atttgtttgt
    10261 atagaaaacc aatttcatat aatccggaat aaccatgaca taatatagag gattgtacac
    10321 ccactggaca ttccagtgaa gcaatcaaaa tgttctttga tttttctacc aatttttgat
    10381 ctttcaaaaa tattcccaca tacagataga gcaaactgat acctggacta ccataacacc
    10441 aagcatctct aaaatattct ttgttatcta aatcactacc cttactatat tcgtccatat
    10501 tgatagccga tttccactta tattgattag tcccatctgc tatttctaac ctatcatata
    10561 ttttaataat attctttaaa aatttttttg tttttgaatt tgtaaatcct ttaatgcaag
    10621 caatagctac cattatccct actcctgcca acccatgtgc tactcctaag ttcaagcatc
    10681 ccttaggaaa aatctcactt tctatgattg ataattggtt ttgggattta acataatatg
    10741 gagggaggcc gtgattattt acaaacaaat caattagctt attaattata tcagaaataa
    10801 tatcattaaa tttttcatca tctttaatca gtaaatatac tagtattcca gatattccct
    10861 caattatatc ataattcaag ggagacagcg tatcggcatc tatttgatgt attgtatcct
    10921 ctatagaata acaaatataa ttatcaatgc tatttattaa atccgagtac ttcttatcct
    10981 tatttgctaa atgcaataaa cttaatgcta aacctgcagc acctgaatat agagaactag
    11041 atacgatacc attatttgat aatattttga caatatatat aaggtagtta tcaatttggt
    11101 ctttatattc atcataatta atttctgata acagtaatat tacacctggt aagcccgcag
    11161 ctagagagta gttttcataa gagttatata tcgtatcact ttttatttta atgtcccatt
    11221 cctcaataat tcttctctga agtaattcaa ttattttaga ctcatcatac atttccatac
    11281 tcctctgaat aatagatttc ttggtactca ggacatttat gtaaaagttc tacatgagta
    11341 cctactccaa ctacttctcc attatctaaa actactattt tatctgcttt ttgagcagat
    11401 tttatattat gagaaataaa tattgaaatt ttgtcttttg cattcttttt aaatgtgtca
    11461 aacaattgct tttctgaaat tggatctaac gctgaactag gctcatcaag tattacaata
    11521 ggtgcttctt taaaaaaagt acgtagcaag gcaatttttt gccattgacc gccagatagc
    11581 tgtctcccat tattgaacca acttcctaac tgagtatcca agtcaatcct accacctctc
    11641 ttaataaaat ctatattgaa atcatgtgat ataagattaa tactttcctc aatatccatt
    11701 ttagataaat cacctagaca tatattttcc ctaagtgaaa gttcatattt tacaaagtct
    11761 tgaaataaag cagaaatatt attttgaaaa aatgtttcat tatccttaaa atccaaatta
    11821 tcatataaaa taactccttt ggaagggata tataaccccg ccaaaagctt gaccaatgta
    11881 cttttcccgg atccattttt tccaatgata gcaactagtt catttttcaa tagctttaga
    11941 tttaaggatt ttacagcagg agtattattc ccattgtaga tatagctaac atctctaaac
    12001 tccacctcgc ttatatcaac tttggataca ctattacatt gtttatctga ttgactactg
    12061 tcatccaaaa acataagcaa ttgttccata tataaatttg tgttattaat aatgtaaata
    12121 ttgtggatta tatcttgcga atatgtgtct actcttccaa atgcctgtat caaactcacc
    12181 atattcccaa gtaatagttt tccttgtctt atcaaaagta ccataaatac tattcctaca
    12241 agaccaatta tatttaacac tcctcctaat aataggttaa aagaaatttt ttttcttgat
    12301 atactaagat cttgcaaaat aaactgttct tttaattgtt tatactcatt tattaaatag
    12361 tcacttatac catttaattt aatttctttg aatgaaaaat catgagttaa caaataattt
    12421 agataccaga cttttcgctc tttatctgct ctcttccact gtaataaaaa ttccatttga
    12481 ccaactttga taaatagtac taatgataaa atcggaatga ttaataatag aagtgcaaac
    12541 tctaatctcc aacttcctat atagtataaa cttaagaata gagatactgt agaagataac
    12601 aaagacagta ttgcattgag caattgtagc ggcttatatg aaacaccttg atttaatttc
    12661 tctaccaaat tgtagatagt ggactgttca aaatcaggca atttcaacat tgcaactctc
    12721 tccattaact gcgtactcaa attgtaagaa agtaaaaaac caattttctc cccaaaatat
    12781 gagtttagct gagtaactac agcagaacaa atttgtatga caacgtatac ggatattata
    12841 taggacaatt gccctccaga aataatagta ttaattagct cttgagatat caataggctg
    12901 ataactggta tcacaccatt aattaatgtc aaaacgatta atccactaat atatttctta
    12961 tcaactttat aaatcattct caagctactc gggattccac aaattgttct aaaaaaatca
    13021 ctatgagtaa actctggcat tgtcctacct cctatactgt tcagaaataa ttatcgaacg
    13081 taaaatataa taaatttccc tttctctttc tctatcaata ccgactagtc gattattatg
    13141 tacgtgaatg atactatcta ctatagaaaa tctttgttct ttagagtatt ctttcaatat
    13201 ctcttttaat tctattaact cattttttaa attttggaca ttttcgctat ctaaaacatg
    13261 taattcatct attctctcga tagcttcttg atatttctta cgttctttgt ttatattaaa
    13321 tttatcagtt ctaggtgaaa caaattctaa aaattctact ttagttacat agtcaaataa
    13381 atactctaga tagaaatatg gtattaatac tgatatatat tttatatcca aagaaatatt
    13441 ccctttttta ttttgattga tgatttccat attcaaataa ctatctaaac agaatatatt
    13501 ctcaattttt tctaatgttc gtttccctcc atatctttca atttctctat catatgtact
    13561 aatctcataa ttaaccatta cattattagt aatagctttt ttcaattctc cttgaatagt
    13621 ttgaaatact tctaagttat tatctgcttt aattctaagt ctgatttgtg agtgtttttc
    13681 aatgtatcta agataaaata atcctccctg atatttatct attaataatt ttatattccg
    13741 taaataatca gttataaatt cgtcctgacg attattagga atatataatt ttaaatatat
    13801 ccagtcagta agagggagtt tttctcttga taatcgttct accctttgca tattgctttt
    13861 atttccataa ctattataaa actctctctc ttttttaaaa ggaataacaa tctcagaagt
    13921 tactgattta ctatttttta aaaatactcc gtcatcatca ataatttctt gaattatcat
    13981 aaattcaaaa ttatttttct tagctttcga aaacatatca gtgagtagga ggatgtctag
    14041 atgctttgta agatcaatat ttattttatt gtcaatgtta accacattaa atttatgagg
    14101 gatatttttg gatttcaagt acgaacaaat atttttatca gttatttcat tcaattcatt
    14161 tttatatatt ttccaagttt ttggagaaat aacaatattt ctataacaca atcttggtac
    14221 aaaattaaat ttagcataca ccaaatccca tggaatattt ccaaaatagt cttcagaaat
    14281 atcgcataga aacctaactt cattgcaaaa taacattcta ttgtacatat tagtcacata
    14341 aaatttaatt agttcacctg tcaatttctc tcttgcataa aatttccctc cttccccaat
    14401 accaatgtaa atattatcta atttaatttc atttttagaa gagtttaaaa atagcgaaag
    14461 tgtataattg cgaactgtat tatttctcat aacattacag tctctaaaag tttcaggcat
    14521 aaattctatt tcacaagtta ctataccttg attattattc caattattac agtaattaac
    14581 cattttttga tgatactcat taaacgattg agaaaattga gaaaatcgcc ctgagcttgc
    14641 acccaagtta cttgtaccaa ctagattact caagtgaaat tgtaccgtat ccgtttctaa
    14701 cgtttttgta acactaaaga ataactccat acctcctact tcatattttt tattttcttt
    14761 tagaaaaagt ccttctaatt tttgtaaatc tatattagta tcagttctaa cagcatatac
    14821 gtataaatct aacaagactt tttctaaatt atcagaataa tatttaactt taggctctgt
    14881 ttcaataatc tcatttttag gatgtgtata atcaaaggga gctccaatgc caaaattact
    14941 atccatcatt tcaattatag gaacctcttg attcaatcca tatttttcta aaaacttatc
    15001 tttatagtgg tcaatatata attttttatc gtccatattt accttttcga taaactgagc
    15061 acattcttca agggtattct tatattgatc atctaaagtg atttgagatt tattaaatag
    15121 atctacttgg acataattag aagaataaca gatgtcacac attttagcac atatgttaga
    15181 taatatttcg tttccctcgc caacatctga cttctcatat cgagatacga gatatacaat
    15241 ttgtttcaaa gctttcaaca attcattgca tcctaactta gaaacagtgg ccagcaaaaa
    15301 atcccagtca ttattttctt tatttttaaa tctcaattcc gagagtaaat aattattttt
    15361 tattaactca attatataat tagttacaat ctctttcttt tcaactccat atttttgcat
    15421 taatgtagaa tgcaaattat caaacgaaat aaaactatca ctacacaaac taacaattaa
    15481 ttcatatgcc tttgtatttt tgatactcac ctcttcttca tttttcttta atgaatacaa
    15541 ttggacagct cgattcccat ttatataaac agctctatta actttaaatg ataaaatcgg
    15601 ataattgtcc atttccaaca tatcaataaa tttcatatac caatcgctat caggtttaat
    15661 agatttataa ctagaatttt ctaatgacaa actagattta gaagcaaatt tcccaatact
    15721 tatttctgaa aatagtccaa aaggtgtagc tctattcatt gaacgtttgt aatatttgta
    15781 agtagatata aaaagctgac taatttgctt atcttgtgtt aatttatttt gataatattt
    15841 taataaactt tgatatacta atggacttgc tacttgtaat tgctctaaaa aaacactatc
    15901 tttcctaata aaatcaaaaa aatcatttat tgtatcaaaa atatctatat ccccagctcg
    15961 aatagaattt ctaattaaaa aatcttgagc ctcaaactta ttagccatat aactctccta
    16021 accattattt taaaatatta ccatttttta ttatactagt taattctcag aagcctaccg
    16081 acatatgatt ttaatagtaa taaaatttag attcactttc attcaaaatt cgtgaatcaa
    16141 ttacttatca gagtaaatat tataaatctc ctcttactta gtgaaataaa aacaatttta
    16201 ttttattaag taagaggagg gtaattcatc gctaccctcc cctaccctac taaaatcatc
    16261 ctgtgatatg aatagagcaa tgaccattac aagaaattgt attgcctgga cacattaaca
    16321 ctcctgtaac acatcctggg gtacagagag atacgcttgt aattcttggg gaagcgccag
    16381 aattatcttt agtcactttt accaaatcca agttaaaatc gtcgttactc attttttgag
    16441 tcctccttaa aattttttta tttttgttcg aacaattgaa ttatagaatt attttttcag
    16501 aatataatca gaaattggca atatagaaaa agttttcgac acgttttaat aaaatatttg
    16561 taatactatt ttgaatctac tatggattaa atactacact aagattcgaa aactataaat
    16621 tgatataata tagttataaa aacaagatac gaaaaagcaa tgtaactaac tcctgagaac
    16681 tttaatttat tgattagtgt taaaaagacg ccttacaaaa tatgacatcc tatctagata
    16741 cgacttataa atccaaaaac attaagtata gaagaacagt tgatattaat cttgagttat
    16801 tcactctatt atccaactca acgtcttcta gcttttgatt ttggtaatgg aatagctaca
    16861 gtcaacaaaa caataacatg gggagaagat attcttcttt cttcaagtcg attttactta
    16921 gacaacttag aagaatagct attgatgtcc cagaaagacc ttttcaacga cctaaaagaa
    16981 acacaccata aagacacaaa tcagactcgc tttaaaaata catcatgcat gccaattagt
    17041 ttttttcaga tggtcatacg catgatttta ctcactttaa agaaaaaatg aatcatagtt
    17101 taacagaaaa tcacttgtct gtgtgtattt gagttattta ggcattgtaa atcttcatga
    17161 gaatacattt attcctatta aaaattctaa aaatcatcca ttgactgaag aggataagca
    17221 gtttaataga gagagggcta caatacgaat taaaattgag tattttaata ctaagtttaa
    17281 aacttttcag attaaggaat aaccttatca caatcgaaaa aaatatttga gaatggtcta
    17341 tttatttcgg actttactaa gtgagacgta ctaataatca tacttcaaat atctgatcct
    17401 taactatacc ataaaaatac ttgttagtgt aatgttcgct ttagtaagtc aagtggacat
    17461 tacccatcca taattagata ttagcatctt ttatatcaag tagttttgtg ataaaatgta
    17521 attattccat ataaattttt tctaatgatg gtttagtctt ttatcattag aaaacttatg
    17581 ggactttttt caataaaata agcgccataa gttctatagg ggattcaccc actataaaac
    17641 ttatggcgcc tattttagat acctaatatt atgtattttt tgcttttaaa gacttttacc
    17701 cagtctctat tatcttattt ttatttacat tcggtattaa gttttatgaa tttttcctta
    17761 ttaatcgttc ttattgctgg cttactatct gtaataatct ccttcactat attttcataa
    17821 atctgttctg ggatatcact tggtttttca ggagatagat atagtttagg tatcatagta
    17881 ttatttaatt taaaaatctg ttttttatcc actactatat tgcggacaaa tggaacttta
    17941 tcccctgccc ttatcaaaaa ataactttct ctgaactttt tatttcctcc acatttagct
    18001 atcatcgtag ccttatgagt ttgacactta aacaatatct tgttattttg aacatttgaa
    18061 tgacagatat aataatgcct tattaaggct aaatcagaat ttacatcagg gaaaggcatt
    18121 aaaaccttaa taacatcctt cttgctaatc aatgactaat ctcccacttg attcgacttc
    18181 aacataaact ggattcaaca attcctcgtt tgtacttaac gaatccagca attctaaatg
    18241 ttcctcgttt aaattcataa aatcctcttt tgaaaataca aaattctttt gatctatcct
    18301 taaaatttca tagtcgtagt caggctccga actttttaaa aggtctaaaa tttcaatatc
    18361 atcatctgta atatcttttt cgctcattgg aatttgtttt tttccagcat caatttcttc
    18421 tttatgagta gaccacattt taaattgatg cgtcaaatca gataactcgg aatctgtcag
    18481 tgtattaata ataaattgac ttattctagc attactttca tcaatatcaa aatcacattg
    18541 tttttgttta agataatctt gaactttagc ttctctatag gtgatatcac cgtaaaaatt
    18601 tgaaaatact ggtccatttt tataagcttt taaatatgta aaatcagagt cttttttttc
    18661 tacaaattga aacatttcat atagaaacaa gaatttttgt agttgtaact ttgagaactt
    18721 agtaatatct tcttgcttgt taagccaagc aatcttatct aacatacttt tggaagtatt
    18781 taaaaccata ttctactcct tatgattaca aataaaaaca caagcaccac atctgtcacc
    18841 tgcgttcatc tgtttccctt ctatacttat atagtacaac tatgtataac ttttgtcaag
    18901 gaatttcact taaaaaatct agtagagaat agtttgccgg tagtttggaa cttactagat
    18961 tacgacatac ctgttgtatg acaaataagc cacccgtatg acgaatggct atgatttttc
    19021 agatataaaa ttactctact tagtatatga ttgagcgcct tttctggtca caattactaa
    19081 attagcaaca aacaataata caacataaaa agttaaagct aataaattag ttgtgcttct
    19141 aaaattattt tctaaaatta tattaactgg taaaattact ggaatccaaa aaatattaag
    19201 aaaaacttta tttgttgcaa ataatataaa taaactttct acaacagcaa taagtaaatt
    19261 gccacctttc gcaataaaca atgtcaatag catgtggaaa tgatttagca atattagtaa
    19321 taaccaacta actattccta cgtaaaaata atatgaaaag tgttctaact ctatacctac
    19381 aactacccat aaaggaatag taagtaaaga taatagtaaa tctaacacaa aaattttcgc
    19441 tccccatata ctggctgtat ttctcgagcc tttaatattc tgataattat tagcattgat
    19501 ttcttgttca gatactaata aagtgattat cgtagttatc atacaatagc ctaacatggg
    19561 taaaaagata atattttcca atacaattgt gttatttaca gataatatgt aaattggaat
    19621 tgtcaatagt tgtatagtag acaaaatcaa aataatgtat agttgatacg aacctttaaa
    19681 tttaatcatt tcacttttta gcaattggat cattacttaa cctccaattt aacattaaca
    19741 aagaaacaat aaatagaatc aatgatagaa atacggtaaa tactaccatt ttaacgtctg
    19801 ttacatgatt tgttaaatct aaatctcctg acggttttat atacataaga ctataagcaa
    19861 ttttataatg atatgtaaaa ggaaagaaga accaaaagct actttgagcg ataaaaggtg
    19921 caaccaaaaa acaaatcaag gagttaatag atactaagat ataggggttg atccgtttcg
    19981 aaaatagata caagagtggc aatacccata tggatgttat cgaaataagt actaaacaaa
    20041 ttaagtcacc aattatattt aatgatatta agtcgccata caaaaaatta cttgtaaata
    20101 ataatatagc taaaaaccat acgttcgaaa tgagtaaatc ttttaatttt aaaagtatct
    20161 ttacgatata tatttttatg ctatcatttc gaaagtatat attctggaag tttcctgcag
    20221 cttcttctgc tttataatca tataaaaata acaatccaat aagcgtgtac aaaaagacgg
    20281 cttcccacca atatattgaa aaactttcta gaatactcgg tccaacaagt aatacagcta
    20341 ttaaaatcga caatccagga gctattatca agaatttttt ggatgtattt tttcgctgtt
    20401 ttaaccattc tgatttaaat atttttatca tattgcgtca cctccatgaa caattcttat
    20461 aaataaagat tctaaatcat cactttgaac attcgaacca tcgtaaaaaa tttgaccatc
    20521 atgtaaaata acaactttat ctgccacctt actaacttca tacagttgat ggctagataa
    20581 aagaattgtc attcctgatt tctttaaaga aatcattaaa ttcaacaatt cctttatacc
    20641 atctggatcc aatccattgg taggttcatc taaaatgagc aaatctggac tagtaattat
    20701 tgccatacct aatcccaaac gttgtttcat acctaaagaa aagctccctg cttttttctt
    20761 tcccgtatta gatagcccaa tcaagtttaa tacttcatta attcgttcgt cagaaatgtc
    20821 atataacaat gctcttgttt ttaagttatc ataagcagat aagttcatgt agatagctgg
    20881 agtttcaata agcgctccaa tctcatatat acccgcattt tttttcccat taaaaataac
    20941 cgtaccacta tcagcatttt caagaccaaa aataatcttc ataattgttg attttcctgc
    21001 accattaata cctaataatc cacaaatact cccctctttt atttcaaaag aaatattttt
    21061 cagtacttct ctatccttat atgattttct aagtttttga acttgtatat tcataactat
    21121 aattcctcct tgttttatac ttgtatgtta tactttattt ttcaaaattt gttcagaatt
    21181 tccaatttta caaaattaaa aaaatagaca gtcctcaatt tagaaaacca tctattttta
    21241 tacataacta ttatatggaa gctatctaat atatccttac agaattattt tttaataagc
    21301 aacgtcactt gagcgccacc tctatctgga tttgataaaa acaattctcc taaatgtcta
    21361 gttgcaactt gtttagcaaa tgctaaccct aaaccatagt gcttattatt cctaccttta
    21421 ttctcagtat aaaataactt atctgcattt aataaggact gttcagtaaa aggcagacca
    21481 ttattccaca ctacaaaatt aatatactct gtttcctcaa tgatagtaag cgtaactttt
    21541 ttttctccag aacaatatct tgctgcattt gctaaaatgt taattaatgc ccgatttaaa
    21601 ttaaagcgat ttcccttaaa aaatattaat tttgtagtat taataatttt gaaatcaacc
    21661 tttgcattat tcattacaga tttcgcttct actgacagct cacttaaaaa ttcggataaa
    21721 tgtatctgtt ctccataatc tttatcttca attagtaatc ttgaataatc aatcattgaa
    21781 ctaaagtatc tttcaaaaac tactatactg ttattcattg actgagtgta ttccttctgt
    21841 tgaacagtca agttagttaa ttcaagcaac tctaaatttc cctttagtac tgttaaagga
    21901 gtttttacat catgagctaa tgcaccaact tgaaaagata aatcttcctt ctcccttctc
    21961 tctgatttga gtaaattagt taactcgtcg tccttttgat ataatacaga aagaatttca
    22021 tcgaactctt gtatttgagc aggaatgttt ttatctttaa atgttaactg tcccatgttt
    22081 aaagtctttt tttgtatgag gagaaaatta tttgaaaatt cttttattaa tcttgtaagt
    22141 gaccaaatga gtaaaattgt ttcgataacg aagaaaaata aataagaaaa tagattaaat
    22201 gaaaagtgac gcaaattcgg attaacaaac tcaggtatca tgggttgcct gacagtaagt
    22261 acaatctctg aattagcgta atacccataa tacactgcat cattacttat ggattcattt
    22321 ttagcaaaaa cttctcgata ggctggcaaa tccttttttt gatagttacc ctcttcaatt
    22381 gtacccgtct tgcgattaaa tacaacatag tcaaatatag agttattcat tgcttggact
    22441 acatcactta aattgctgct atcactcact gaaatttcca ttttagagcc gtatacattt
    22501 aattgtccag taaaaacaag taaataagta aatataaaaa ataaaagtat actcagtaac
    22561 gtacctgtta ctagttctaa aacagtcctt attatgcgcc ctctaattgt actcttctta
    22621 ctcatgccac ttgtatccca tacctctaac tgtttttata ggattaattc catacgatga
    22681 gaattttaat cttatttgat agatatactc agatattgaa cgaaagaggg tttcagcatc
    22741 atcatcataa acattttcat atatatcttg tacagtaaaa atttttcttg gattgctaga
    22801 taatagctct atgatatcat attccctact tgtaaaagca agactatctc cattaataca
    22861 aacaattttt tcttgtaaat aaatcgttat tggggataat tctcgaacaa tttgattact
    22921 taattcacct tgtttgtatc gttcttctcg tttgagattt gcagcaactt tggcaattaa
    22981 ttgattgatg ctgaaaggtt ttgtaatata gtcatctcct cctaaattca accctgatac
    23041 tatatcatct tcggtatctt ttgcactaac aaaaataata ggagatctta ctttatttct
    23101 aatctgctta caaatttgca taccatctat attaggcatc attacatcta ataaaatcaa
    23161 atcaaatcct ttgaaattat taatattgat tggtacggtg acttcttgat acgtcgttac
    23221 ctgatagttt ttcatctcta aaatagttcg catcagtttc aaaatttcaa aatcgtcatc
    23281 tacaactaat atcttataca ttctatcacc tcaaaatatt ttagagaact atctgcaaag
    23341 ctccgtattc ttgataaaga atagtctcaa tacatcaatt tgtaattgtt ctttattttt
    23401 taaattatat ttttaaaaaa tagtacaaat ctattttaca ctatcttgaa caaaattcgt
    23461 aatatttaat aatctaattt gagtgccgtc aatgtcatta cctatacagc aattatcata
    23521 caataattta attacctcat ctggttgatc tttcaaatga tatttctcaa tgattaaccc
    23581 aagtgctgct gaaacctttg gtgttgaaat ggatgtccca taagcataag tatatttccc
    23641 ttcaagtgtc ggtacaataa cccattcttt ttcaaatgtt ttatcatttg cccactgttc
    23701 atatccaact gttgctagtt tatgacttcc tcctcctgtt gcatatatat ctattacatt
    23761 atttccttta tttgaaaaac tagatacaaa atcgttatca tttactgacc ctactgttac
    23821 aacattgtct aatcccgcag gaatatccat aacttttcca tctatatgtg aataatcctt
    23881 ccccttaagt tctccaaggt aatgtttcaa tgattcttga ttatttaaat ctagaccctc
    23941 atcacctact gaagcaacaa ttattgaacc ctgactatac gcataattga ttgctctctg
    24001 ataaatgtta attaatgctg tttggtcatc ttctatagtt gagtttttta gcaagtattc
    24061 acccaaactt agattaataa catcaacatc atctttcgct gcttgaataa ttgcctttaa
    24121 tatccactga tcttgtgcat ttcctttatc aaatactcga tacattctaa ctttcattcc
    24181 aggagcaata cctaaataat ttccgtttga tgaaatctgt ccaaccacag aagttccatg
    24241 gcctgtttta tctaatatat tttgattatc aattaagccc gtttccaaat ccgctgtaaa
    24301 gttcttgaca gaaataatat ttgaagatac ttctgggtta tcgtaagtaa cacctgagtc
    24361 tatcacacca atagtagctt caccagtaga tttatgacta aattttctac ctgtaccaat
    24421 actcttttgc atatcccatt gataatccca aaaattcata ttgttagttg taattacact
    24481 ttctccatac agataagtga cattaggctt tacattcatc ataccatcaa taactatttc
    24541 ttttatcgaa ttattatttt ctttctttat ctcttcttta ctttttccag tcgaaacagt
    24601 aataagattt atttcaggaa taatatcgat aatttgcata ccctgtttaa taaatttttg
    24661 ttggatagta tcaactgttt ctgtctcttt cagtagtata ttatatttaa aatctgatcc
    24721 agcagtcgct tgaactccat ggactgaaaa aaataatgga aataatactc caactgataa
    24781 taagaacttt ttattcatat aatcctcctt aatgttttta tttgagatta taccagagaa
    24841 aattcagatt ttattcagag aaaaaatcat ctttacacta ctagtgaaat tcaaatttaa
    24901 gaaagaatca atttctaaaa tttttcatgt cctaaaaacg gcataagttt tgaacttgtt
    24961 cagattattt tctatccctt cttccactta tatcctgtcc agcatgctaa agcaagtaaa
    25021 actaaattaa agatgataaa gaaagtcgta aaaccaaata atccattttg agctaaatct
    25081 gccgtgtaaa gttcagtctc agtaaagaac agataaattc cataaccctc cacgaaaata
    25141 agaaaactga caaaaccaat caggaaaagt ccactggcaa ttagaaagag tctccataaa
    25201 agaatgagaa ttcctcctac tgctaaaaaa attactggga taaggagtaa atcattcatg
    25261 actttctcct tcctagtcaa tcaattgacg ataatgggtg gcaagagagg aatcaaactc
    25321 ttctaatttt tgaaccaagc ccaaatactc ctctttctca taatcttcaa agtccacacc
    25381 tcgatgattc tgaagagcga tttccaattg gctagtgagt tcttgtatag aaaagctgta
    25441 atcccccgtc acttcctcat aatgttcctt tagctccttg taggcttggt attcttcagg
    25501 cgtttgaaat ccctgtacta aggcttcttc taattgataa taggtatctt ccatcataat
    25561 cgttacctcg tttctttcta tctttattct accgcgcttt tcttttcttg tccgctattt
    25621 atatctattt cttaatctaa ttcaaaagaa agttgttctt gcttttcttt tcctttttcg
    25681 tggaattgtc ttaaggcctg atcaataata tctaaatccg tttctgtttc aatcaatggc
    25741 gcgagtacat cgtattcggc ctttttagtt tgataatcct cttcctttgg aaaatttttc
    25801 tcaatttcta ctctagcagt agtccattta tcctttaatt catccaataa gttctgagtt
    25861 ttcacttggt catctttaat gtgatcaatc gtatgctgaa gcctttgaat tgtccctaaa
    25921 ggagaataca aatctaaact gacagaatat tgattttctc ctacaatctt aacagagaag
    25981 gtttcaggaa gaggttgatt tgttggaa
//
