LOCUS       NZ_CP113114            14807 bp    DNA     circular CON 14-JAN-2024
DEFINITION  Streptococcus pneumoniae strain NP1 chromosome, complete genome.
ACCESSION   NZ_CP113114
VERSION     NZ_CP113114.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2310574)
  AUTHORS   Sagar,V., Kaur,G. and Gupta,M.
  TITLE     Genome sequencing and assembly of Streptococcus pneumoniae strain
            NP1 isolated from nasopharynx
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2310574)
  AUTHORS   Sagar,V., Kaur,G. and Gupta,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2022) Community Medicine &SPH, Post Graduate
            Institute of Medical Education & Research, Chandigarh, Room No 529,
            Research Block B, PGIMER, Sector 12, Chandigarh, Chandigarh 160012,
            India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: MaSuRCA v. 3.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 356.0x
            Sequencing Technology :: Illumina Novoseq 600; Nanopore GridION X5
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/14/2024 02:39:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,409
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,154
            CDSs (with protein)               :: 2,154
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 181
            CDSs (without protein)            :: 181
            Pseudo Genes (ambiguous residues) :: 0 of 181
            Pseudo Genes (frameshifted)       :: 86 of 181
            Pseudo Genes (incomplete)         :: 87 of 181
            Pseudo Genes (internal stop)      :: 72 of 181
            Pseudo Genes (multiple problems)  :: 53 of 181
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:47:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 82190
            Orig. end                         :: 96997
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP113114.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..14807
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..14807
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14807
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:9807](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9807
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(139..1149)
                     /locus_tag="OTU45_RS00450"
                     /old_locus_tag="OTU45_00450"
     CDS             complement(139..1149)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /locus_tag="OTU45_RS00450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00450"
                     /product="YeiH family protein"
                     /protein_id="WP_000009157.1"
                     /transl_table=11
                     /translation="MSFLSKNGAGILACLLISIVSWYLGGFFPVIGAPVFAIFIGMLLH
                     PFLSSYKQLDAGLTFSSKKLLQYAVVLLGFGLNISQVFAVGQSSLPVILSTISIALIIA
                     YLFQRFFALDTKLATLVGVGSSICGGSAIAATAPVIDAKEKEVAQAISVIFFFNVLAAL
                     IFPTLGTWLHLSNEGFALFAGTAVNDTSSVTAAASAWDSLYQSNTLESATIVKLTRTLA
                     IIPITLFLSYWQSRQQENKQSLQLKKVFPLFILYFILASLLTTLLTSLGVSSSFFTPLK
                     ELSKFLIVMAMSAIGLKTNLVAMVKSSGKSILLGAICWIAIILTTLGMQTLIGIF"
     gene            1298..2467
                     /locus_tag="OTU45_RS00455"
                     /old_locus_tag="OTU45_00455"
     CDS             1298..2467
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value:
                     1.2e-64. Score: 210.7. Matches aSDomain:
                     nrpspksdomains_OTU45_RS00455_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /locus_tag="OTU45_RS00455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00455"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_000366343.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4e-63, bitscore:
                     210.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 2.5e-07, bitscore:
                     27.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2e-07, bitscore:
                     27.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTTP
                     DHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTSQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     aSDomain        1391..2443
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_OTU45_RS00455_Aminotran_1_2.1"
                     /evalue="1.20E-64"
                     /label="OTU45_RS00455_Aminotran_1_2.1"
                     /locus_tag="OTU45_RS00455"
                     /protein_end="382"
                     /protein_start="31"
                     /score="210.7"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     AFTSQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     gene            2464..3234
                     /gene="recO"
                     /locus_tag="OTU45_RS00460"
                     /old_locus_tag="OTU45_00460"
     CDS             2464..3234
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /locus_tag="OTU45_RS00460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00460"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_000616157.1"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKCMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQ
                     DNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAF
                     DFSFKYGACLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            3231..4223
                     /gene="plsX"
                     /locus_tag="OTU45_RS00465"
                     /old_locus_tag="OTU45_00465"
     CDS             3231..4223
                     /EC_number="2.3.1.274"
                     /GO_function="GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="plsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /locus_tag="OTU45_RS00465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00465"
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="WP_000717456.1"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQ
                     YLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVV
                     ADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            4229..4462
                     /locus_tag="OTU45_RS00470"
                     /old_locus_tag="OTU45_00470"
     CDS             4229..4462
                     /NRPS_PKS="Domain: PP-binding (8-72). E-value: 3e-11.
                     Score: 35.5. Matches aSDomain:
                     nrpspksdomains_OTU45_RS00470_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /locus_tag="OTU45_RS00470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00470"
                     /product="acyl carrier protein"
                     /protein_id="WP_000136447.1"
                     /sec_met_domain="PP-binding (E-value: 1.8e-10, bitscore:
                     38.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.00064, bitscore:
                     17.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     aSDomain        4253..4444
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_OTU45_RS00470_PP-binding.1"
                     /evalue="3.00E-11"
                     /label="OTU45_RS00470_PP-binding.1"
                     /locus_tag="OTU45_RS00470"
                     /protein_end="72"
                     /protein_start="8"
                     /score="35.5"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQNVGDVVK"
     gene            <4508..4798
                     /locus_tag="OTU45_RS00475"
                     /old_locus_tag="OTU45_00475"
                     /pseudo=""
     CDS             <4508..4798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="OTU45_RS00475"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00475"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RNIGQAGKILADSGYQGLMKIYPQAQTPRKSSKLKPLTVEDKACN
                     HALSKERSKVENIFAKVKTFKMFSTTYRNHRKRFGLRMNLIAGIINHELGF"
     misc_feature    complement(4516..4531)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(4840..4853)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.31"
                     /tool="antismash"
     misc_feature    4861..4874
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.29"
                     /tool="antismash"
     gene            5001..5231
                     /gene="blpU"
                     /locus_tag="OTU45_RS00480"
                     /old_locus_tag="OTU45_00480"
     CDS             5001..5231
                     /codon_start=1
                     /gene="blpU"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /locus_tag="OTU45_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00480"
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="WP_001093076.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.6e-16,
                     bitscore: 56.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKKMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAVRGLQL
                     GIKTRTWQGAATGAVGGAILGGVAYAATCWW"
     misc_feature    5018..5032
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.48"
                     /tool="antismash"
     gene            5234..5359
                     /locus_tag="OTU45_RS00485"
                     /old_locus_tag="OTU45_00485"
     CDS             5234..5359
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /locus_tag="OTU45_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00485"
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346297.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     misc_feature    complement(5742..5759)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            5796..7142
                     /locus_tag="OTU45_RS00490"
                     /old_locus_tag="OTU45_00490"
     CDS             5796..7142
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /locus_tag="OTU45_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00490"
                     /product="IS1380-like element ISSpn5 family transposase"
                     /protein_id="WP_001826500.1"
                     /transl_table=11
                     /translation="MNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKER
                     ISKYLVTNDQRRYCRYSDSDILVQFLFQLLTGYGTDYACKELSADAYFPKLLEGGQLAS
                     QPTLSRFLSRTDKETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTYGKQEGVAY
                     NAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFRMDSG
                     FATPKLYDLIEKTGQCYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSETLYQAG
                     SWSHKRRVCQFSERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIKEMKEGF
                     FGDKTDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFLHVVGKCVR
                     TGRKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMH"
     misc_feature    complement(7155..7170)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            7654..9807
                     /gene="comA"
                     /locus_tag="OTU45_RS00495"
                     /old_locus_tag="OTU45_00495"
     CDS             7654..9807
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="OTU45_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00495"
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="WP_000668279.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.2e-41, bitscore:
                     137.4, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1123.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRDRFAEEWTGVTLFMAPSPDYKPHKEQKNGLFSFIPILVK
                     QRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     gene            9820..11169
                     /gene="comB"
                     /locus_tag="OTU45_RS00500"
                     /old_locus_tag="OTU45_00500"
     CDS             9820..11169
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="OTU45_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00500"
                     /product="competence pheromone export protein ComB"
                     /protein_id="WP_000801606.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLINQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            11339..12046
                     /gene="purC"
                     /locus_tag="OTU45_RS00505"
                     /old_locus_tag="OTU45_00505"
     CDS             11339..12046
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /locus_tag="OTU45_RS00505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OTU45_00505"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_000043305.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQGLK"
     misc_feature    complement(12117..12130)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.09"
                     /tool="antismash"
     misc_feature    12828..12842
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    13588..13598
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 aaatcaaaga gcaaactagg aaactagccg cgggctgctc aaaacaccgt tttgaggttg
       61 cagatagaac tgacgaagtc agtaacatat atacggcaag gcgacgttga cgtggtttga
      121 agagattttc gaagagtgtt agaaaatgcc gataagggtc tgcataccaa gagtggtgag
      181 gatgatggca atccagcaga tggctccaag aagaatggat tttccactgg atttgaccat
      241 agcgaccaga ttggttttga gaccgatagc actcatggcc atgacaataa ggaatttaga
      301 gagttctttg agaggagtaa agaaactact ggacacacct agagaggtga gtagtgtagt
      361 gaggagagag gcaaggataa agtaaaggat aaaaagtggg aagacttttt tcagttgcag
      421 gctttgcttg ttttcttgtt ggcgactttg ccagtaggat agaaagagcg tgatagggat
      481 aatggccaaa gtacgtgtga gtttaacaat ggttgcagac tcgagggtat tgctttggta
      541 aagactgtcc caagcgctgg cggcagccgt tacagaggaa gtgtcgttga ccgcagtccc
      601 tgcaaagagg gcgaagcctt cattggatag atgaagccag gtgccgaggg ttggaaagat
      661 gagcgcagcc aagacattga agaaaaagat aacggaaatg gcttgggcta cttccttttc
      721 cttagcatca ataacgggcg ctgtcgctgc aatggcagaa cccccacaga tagaagaacc
      781 tactccaacc aaggtagcca gttttgtatc cagggcaaag aaacgctgga agaggtaggc
      841 aataatcaga gctattgaga tagtggacag gatgacaggg agtgaagatt ggccaactgc
      901 gaagacctgc gagatattga gaccaaaacc aagcaagaca acggcatatt ggagcaactt
      961 cttggaacta aaggtcaaac cagcatccag ttgtttatag gacgagagaa agggatgtag
     1021 gagcatgcct atgaaaatgg caaaaacggg cgcgccaatc acagggaaga atcctcctaa
     1081 gtaccaagat acgatagaaa tgagaaggca ggccaagata cctgctccat tttttgatag
     1141 aaatgacata aaaacctcca aataaaatct attaccatta tagacctata aacaggaaaa
     1201 gtaaaataga aagtggaaag ctatcctcta atgtattttt gcggtcgggg ggcttttgta
     1261 gtataataga gatacgtttt gaaagtagga ggtatctatg gacttaacta agcgctttaa
     1321 taaacagtta gataaaattc aagtttcgtt gattcgtcag tttgaccagg ctatttcgga
     1381 gattcctggg gtcttgcgtt tgaccttggg ggaacctgat tttacaacgc cagaccatgt
     1441 caaggaggcg gccaagcgag cgattgatca gaaccaatcc tactatacag ggatgagtgg
     1501 tctgctgact ctacgtcagg cagctagtga ctttgttaag gaaaagtacc aactggacta
     1561 tgctcctgaa aatgaaatct tggttacaat tggggcgaca gaggctttat ctgcgacttt
     1621 gacggctatt ttggaagagg gagacaaggt acttttgcca gctcctgctt atccaggcta
     1681 tgaaccgatt gttaacttag ttggggcaga aattgttgag attgatacga ctgaaaatgg
     1741 ttttgtcttg actcctgaga tgttggagaa ggccattttg gagcagggtg ataagctcaa
     1801 ggcggttatt ctcaactatc cagccaatcc gacaggaatt acctacagtc gagagcagtt
     1861 agaggccttg gcagctgttt tacgcaagta cgaaattttt gttgtctgtg atgaggttta
     1921 ctcagaattg acctacacag gcgaagccca tgtgtctcta ggaacgatgt tgagagacca
     1981 ggctattatt atcaatggtt tgtctaaatc gcatgccatg acaggttggc gtttggggct
     2041 gattttcgct cctgcggcct tcacatccca gttaatcaag agtcaccaat acttggtcac
     2101 tgccgcaaat accatggcgc aacatgctgc ggtagaagcc ttgacggctg gtaaaaatga
     2161 tgcggagccc atgaagaagg aatatatcca gcgtcgggac tatatcatcg aaaaaatgac
     2221 tgctcttggt tttgagatta tcaaaccaga cggtgccttc tatatttttg ctaaaattcc
     2281 agcgggctac aatcaagact cctttgcttt tctgaaggat tttgctcaga agaaggccgt
     2341 tgcctttatc cctggtgcag cctttggacg ttacggggaa ggctacgtcc gcctatctta
     2401 tgcagccagc atggagacta tcaaagaagc catgaaacga cttgaggagt atatgagaga
     2461 agcatgattc agtctatcac gagtcaaggc ttggtgcttt acaatcgcaa ttttcgtgag
     2521 gatgacaagc ttgtcaaaat ttttacagag caggttggca aatgcatgtt ttttgtcaaa
     2581 cacgctggtc agtctaagct ggcgcctgtt attcagccct tggtgctggc acgatttctc
     2641 ttgcgaatca atgatgacgg actcagttac atcgaagact atcatgaggt catgactttt
     2701 cccaagatta atagtgacct ctttgtcatg gcctatgcga cctatgtggc agctcttgca
     2761 gatgctagtt tgcaggacaa tcagcaggat gctcccttgt ttgctttttt gcaaaagact
     2821 ttggagttga tggaagcagg cttggattat caggttttga ccaatatttt tgaaattcaa
     2881 attttgactc gatttggaat cagcctcaat tttaatgagt gtgtcttctg ccatcgggtt
     2941 ggtcaggctt ttgacttttc tttcaaatat ggagcctgtc tctgtccaga gcattatcat
     3001 gaggatgaga gacgttgcca tctcaatccc aatatcccct atctgctcaa tcaatttcaa
     3061 gctattgatt ttgagacttt ggagaccatt tcgctcaagc ctggaatcaa gcaagagcta
     3121 cgccaattta tggatcaact atatgaagag tacgttggga ttcacctaaa atcaaagaaa
     3181 tttattgatt ccctagcaga ctggggacaa ttactaaaag aggaaaagaa atgaaaaaaa
     3241 tcgcagtaga tgccatgggg ggcgattacg cacctcaggc catcgttgag ggtgtcaatc
     3301 aagccctatc tgacttttca gatatcgagg ttcaactcta cggagatgaa gctaaaatca
     3361 agcaatatct gacagcgaca gagcgcgtca gcattatcca tacggatgag aagattgatt
     3421 cggatgatga acctacgaga gctattcgga ataagaaaaa tgccagtatg gtattggcag
     3481 ccaaggctgt caaagatggt gaagcagacg ctgtcctttc ggctgggaat acaggtgctt
     3541 tgttggctgc tggattcttc atcgtgggtc gtatcaagaa tatcgaccgt cctggactta
     3601 tgtcaacatt gccgactgta gatgggaaag gttttgacat gcttgacctc ggtgctaatg
     3661 cagaaaatac agcccagcac ctccatcaat atgcggttct aggttccttc tatgctaaaa
     3721 atgtccgtgg cattgcgcaa ccacgcgttg gtttgctcaa caacggaaca gagagtagca
     3781 agggcgaccc gcttcgtaag gaaacttatg aattactggc ggctgatgaa agtttgaact
     3841 ttatcggaaa cgtggaagcg cgtgatttga tgaatggcgt tgcagatgtt gttgtggcag
     3901 atggtttcac gggaaacgct gtgctcaaat ccatcgaagg gacagctatg ggaatcatgg
     3961 gcttgctcaa gacagctatt acaggtggtg gtcttcgagc gaaactaggt gccctccttc
     4021 tcaaggacag cctcagaggt ttgaaaaaac agctcaatta ttcagatgtt ggtggagcgg
     4081 tcttgtttgg tgttaaggca cctgttgtca agactcatgg ctcaagcgat gccaaggctg
     4141 tttatagtac gattcgtcag atccgtacca tgctagaaac agacgtggtt gcccagactg
     4201 cgcgtgaatt ttcaggagaa taaaagagat gacagaaaaa gaaatttttg accgtattgt
     4261 gaccattatc caagagcgac agggagagga ctttgtcgtg acagaatcct tgagtctgaa
     4321 agacgatttg gatgcggatt ctgttgactt gatggagttt atcttgactc tggaagatga
     4381 atttagtatc gaaatcagcg atgaagaaat tgaccaactc caaaacgtag gagatgtggt
     4441 taaaatcatt caaggaaaat agcaatcgga gttccaagtc aacggaagta gatggttttt
     4501 agaaatgaga aatatcggac aagctggtaa aatcttggct gacagtggtt atcaagggct
     4561 catgaagata tatcctcaag cacaaactcc acgtaaatcc agcaaactca agccgctaac
     4621 agttgaagat aaagcctgta atcatgcgct atctaaggag agaagcaagg ttgagaatat
     4681 ctttgccaaa gtaaaaacgt ttaaaatgtt ttcaacaacc tatcgaaatc atcgtaaacg
     4741 cttcggatta cgaatgaatt tgattgctgg tattatcaat catgaactag gattctagtt
     4801 ttgcaggaag tctaatagta aaaaagtgat tagaaaacat cttttttaaa aatagagatg
     4861 attttgaaac aaaaaagcta attcaagacg tttcgatgcc aattcaagat ttggatgaaa
     4921 aaaattaata gatactgtta tactaaactt gtcaagtttg taacaagaca aatattaaaa
     4981 ataaaaaaga ggtattcgtt atgaatacaa aaaagatgtc acaatttgaa attatggata
     5041 ctgagatgct tgcttgcgtt gaaggtggcg gatgcaattg gggagatttt gccaaagcag
     5101 gtgttggagg aggagcagta cgaggtcttc agctaggaat taaaacaaga acatggcaag
     5161 gtgcagcaac tggtgctgtg ggaggagcta tacttggagg tgtggcctat gcagcgacat
     5221 gttggtggta attatggatt ttaaaagttt tattattggt ttagtagttg gtatatttgg
     5281 tccttatatg gatgatttaa ttagaaaaaa atttttaaag tcttcggaga agaaaacaga
     5341 aaaatctgtt aaaaaataat caaaactata aatgatgaat ctgaatcaaa attattttgc
     5401 gcatgtaaat aggagtctta tagtaacgag tcaaaaaagg agtaactatg aatcgtaatt
     5461 tagaacggtg ttatctattc tgactaggaa tagatcatac cagaggtggc ttagaaatag
     5521 cggggacatt agaaattgaa gtaataaata ggatgtcgta agtgttacta tcaatgattt
     5581 atttgtttca agcttgccta gggtgtcagt aaaaaatcat tttcctttca ccccaattat
     5641 tcaccccaaa tctaaaaacc atccagaatc cttgccttag cttagatcct ggatggtttc
     5701 ttttttcacc caatgggtgt tttttactag acaaaaaaga gtttcccctt tatggtataa
     5761 gtgtagaaaa aaacacaaaa agaaaggaaa ctcacatgaa cagtttacca aatcatcact
     5821 tccaaaacaa gtctttttac caactatctt tcgatggagg tcatttaacc cagtatggtg
     5881 gtcttatctt ttttcaggaa cttttttccc agttgaaact aaaagagcgg atttctaagt
     5941 atttagtaac gaatgaccaa cgccgctact gtcgttattc ggattcagat atccttgtcc
     6001 agttcctctt tcaactgtta acaggctatg gaacggacta tgcttgtaaa gaattgtcag
     6061 ctgatgccta ctttccaaaa ttgttggaag gagggcagct tgcttcacag ccaaccttat
     6121 cccgttttct ttccagaact gacaaggaaa cagtccatag tttgcgatgc ctcaaccttg
     6181 aattggtcga attcttttta cagtttcacc agctaaacca actcattgta gatatcgatt
     6241 ctacccattt cacaacttat ggcaagcaag aaggtgttgc ttataacgcc cactatcgtg
     6301 ctcatggcta tcatcctctt tatgctttcg aggggaagac aggttattgt ttcaatgccc
     6361 agcttcgtcc tggtaatcgt tattgttctg aagaggcaga cagctttatc acacctgttt
     6421 tagaacggtt taatcaactt ctctttcgaa tggatagtgg ctttgcgacc ccaaaattat
     6481 acgatttaat tgaaaaaaca gggcaatgct acctcataaa actcaagaaa aatactgttc
     6541 tgagccgtct tggagacctt tccctccctt gcccacagga tgaggactta accatcttgc
     6601 cccactccgc ctactcagaa actctctatc aagcaggatc ttggtcgcac aagcgtcgtg
     6661 tctgccagtt ctctgaacga aaagaaggaa acttgttcta cgatgttatt tctctcgtta
     6721 caaatatgac gagtggaaca agccaagacc agtttcagct ttatcgtgga cgtggtcaag
     6781 ccgagaattt catcaaggag atgaaggagg gattttttgg cgataaaacg gatagttcaa
     6841 ccttaatcaa aaacgaagtt cgtatgatga tgagctgtat cgcctacaat ctctatcttt
     6901 ttctcaaaca tctagctgga ggtgacttcc aaactttaac aatcaaacgc ttccgccatc
     6961 tttttcttca cgtggtagga aaatgtgttc gaacaggacg caagcagctc ctcaaattgt
     7021 ctagtctcta tgcctattcc gaattgtttt cagcacttta ttctaggatt agaaaagtca
     7081 acctgaatct tcctgttcct tatgaaccac ctagaagaaa agcatcgtta atgatgcatt
     7141 aaagaacagt cgagatgaaa aaatcgtgtg acgcaccaag ggaggagtct gcccttttga
     7201 ggaaatctag cgaggaaaaa cgatactgga acagcagaaa gtaaaactga cctcatgagg
     7261 aggaagaaag tggctcatga ggtcaggggt tttgtaagtt acatctagtt gagagaggta
     7321 tgaatgattt gggtttcaat agcatatttt tagtgggcag gactcttgtt ctgcctattt
     7381 ttttatccaa aaagtgcagt tgggagggag ataggctcat ttgggaagga agtccagttt
     7441 ttgtttagtg attggggtaa gatagttgtt atcagatgag tttatattct tcgaaaatca
     7501 aattcaaacc acgtcaacgt cgccttgccg tatatatgtg actgacttcg tcagtcctat
     7561 ctacaacctc aaaacagtgt tttgagcagc ctgcggctag tttcctagtt tgctctttga
     7621 ttttcattga gtattaggga aaaggagatg aatatgaaat ttgggaaacg tcactatcgt
     7681 ccgcaagtgg atcagatgga ctgcggtgta gcttcattag ccatggtttt tggctactat
     7741 ggtagttatt attttttggc tcacttgcga gaattggcta agacgaccat ggatggaacg
     7801 acggctttgg gcttggtcaa ggtggcagag gagattggtt ttgagacgcg agccattaag
     7861 gcggatatga cgctttttga cttgccggat ttgacttttc cttttgttgc ccatgtgctt
     7921 aaggaaggga aattgctcca ctactatgtg gtgactgggc aggataagga tagcattcat
     7981 attgccgatc cagatcccgg ggtgaagttg accaaactgc cacgtgatcg ttttgcggaa
     8041 gaatggacag gagtgactct ttttatggca cctagtccag actacaagcc tcataaggaa
     8101 caaaaaaatg gtctgttctc ttttatccct atattagtga agcagcgtgg cttgattgcc
     8161 aatatcgttt tggcaacact cttggtaacc gtgattaaca ttgtgggttc ttattatctg
     8221 cagtctatca ttgataccta tgtgccagat cagatgcgtt cgacactagg gattatttct
     8281 attgggctag tcatcgtcta catcctccag caaatcttgt cttacgctca ggagtatctc
     8341 ttgcttgttt tggggcaacg cttgtcgatt gacgtgattt tgtcctatat caagcatgtt
     8401 tttcacctcc ctatgtcctt ctttgcgaca cgcaggacag gggaaatcgt gtctcgtttt
     8461 acagatgcta acagtatcat cgatgcgctg gcttcgacca tcctttcgat tttcctagat
     8521 gtgtcaacgg ttgtcattat ttcccttgtt ctattttcac aaaataccaa tctctttttc
     8581 atgactttat tggcgcttcc tatctacaca gtgattatct ttgcctttat gaagccgttt
     8641 gaaaagatga atcgggatac catggaagcc aatgcggttc tgtcttcttc tatcattgag
     8701 gacatcaacg gtattgagac tatcaagtcc ttgaccagtg aaagtcagcg ttaccaaaaa
     8761 attgacaagg aatttgtgga ttatctgaag aaatccttta cctatagtcg agcagagagt
     8821 cagcaaaagg ctctgaaaaa ggttgcccat ctcttgctta atgtcggcat tctctggatg
     8881 ggggctgttc tggtcatgga tggcaagatg agtttggggc agttgattac ctataatacc
     8941 ttgctggttt actttaccaa tcctttggaa aatatcatca atctgcaaac caagcttcag
     9001 acagcgcagg ttgccaataa ccgtctaaat gaagtgtatc tagtagcttc tgagtttgag
     9061 gagaagaaaa cagttgagga tttgagcttg atgaagggag atatgacctt caagcaggtt
     9121 cattacaagt atggctatgg tcgagacgtc ttgtcggata tcaatttaac cgttccccaa
     9181 gggtctaagg tggcttttgt ggggatttca gggtcaggta agacgacttt ggccaagatg
     9241 atggttaatt tttacgaccc aagtcaaggg gagattagtc tgggtagtgt caatctcaat
     9301 cagattgata aaaaagccct gcgccagtac ataaactatc tgcctcaaca gccctatgtc
     9361 tttaacggaa cgattttgga gaatcttctt ttgggagcca aggaggggac gacacaggaa
     9421 gatatcttac gggcggtcga attggcagag attcgagagg atatcgagcg catgccactg
     9481 aattatcaga cagaattgac ttcggatggg gcagggattt caggtggtca acgtcagaga
     9541 atcgctttgg cgcgtgctct cttgacagat gcgccggtct tgattttgga tgaggcgact
     9601 agcagtttgg atattttgac agagaagcgg attgtcgata atctcatggc tttggacaag
     9661 accttgattt tcattgctca ccgcttgact attgctgagc ggacagagaa ggtggttgtc
     9721 ttggatcagg gcaagattgt cgaagaagga aagcatgctg atttgcttgc acagggtggc
     9781 ttttacgccc atttggtcaa tagctagaaa gaggagagga tgaaaccaga atttttagaa
     9841 agtgcggagt tttataatcg tcgttaccat aatttttcca gtagtgtgat tgtacccatg
     9901 gcccttctgc tcgtgttttt acttggcttt gcaactgttg cagaaaagga gatgagcttg
     9961 tccactagag ctactgtcga acctagtcgt atccttgcaa atatccagtc aactagcaac
    10021 aatcgtattc ttgtcaatca tttggaagaa aataagctgg ttaagaaggg ggatcttttg
    10081 gttcaatacc aagaaggggc agagggtgtc caagcggagt cctatgccag tcagttggac
    10141 atgctaaagg atcaaaaaaa gcaattggag tatctgcaaa agagcctgca agaaggggag
    10201 aaccactttc cagaggagga taagtttggc taccaagcca cctttcgcga ctacatcagt
    10261 caagcaggca gtcttagggc tagtacatcg caacaaaatg agaccatcgc gtcccagaat
    10321 gcagcagcta gccaaaccca agccgaaatc ggcaacctca tcaatcaaac agaggctaaa
    10381 attcgcgatt accagacagc taagtcagct atggaaacag gtgcttcctt ggccagtcag
    10441 aatctagcct actctcttta ccagtcctac aagtctcagg gcgaggaaaa tccccaaact
    10501 aaggttcagg cagttgcaca ggttgaagca cagatttctc agttagaatc tagtcttgct
    10561 acttaccgtg tccagtatgc aggttcaggt acccagcaag cctatgcgtc agggttaagc
    10621 agtcaattgg aatcccttaa atcccaacac ttggcaaagg ttggtcagga attgaccctt
    10681 ctagcccaga aaatcttgga ggcagagtca ggtaagaagg tacagggaaa tcttttagac
    10741 aaggggaaaa ttacggcaag tgaggatggg gtgcttcatc ttaatcctga gaccagtgat
    10801 tctagcatgg ttgcagaagg tgccctacta gcccaacttt atccatcttt ggaaagagaa
    10861 gggaaagcca aactcacagc ctatctaagt tcaaaagatg tagcaagaat caaggtcggt
    10921 gattctgttc gctatactac gactcatgat gccgggaatc aactttttct agattctact
    10981 attacaagta ttgatgcgac agctactaag actgagaaag ggaatttctt taaaatcgag
    11041 gcggagacta atctaacttc ggagcaggct gaaaaactta ggtacggggt ggaaggccgt
    11101 ctacagatga ttacgggcaa gaaaagttac ctacgttatt atttggatca atttttgaac
    11161 aaagagtaat gttcgtgttt ttagagttaa ataattttta aactgtgaga aagattcttc
    11221 ttgcagtttt ttctttacaa tttttgaaaa acatctgcta tttattcggt tgaattcttg
    11281 tgttttttgg ttttttgtgg taaaatgtgc tcaagtaata cgaaaggcga actttaaaat
    11341 gtcaaaacaa ttgatctatt cgggaaaagc taaagatatc tatacaactg aggatgaaaa
    11401 tcttattatt tcaacttaca aggaccaggc gactgctttc aacggtgtca agaaggagca
    11461 gattgcaggt aagggagtct tgaataatca gatttcatct tttatttttg agaaattaaa
    11521 tgcggctggt gtggcgactc actttgtgga gaaactttca gacacggaac aactcaataa
    11581 aaaggttaag attattcctt tggaagtcgt gctccgcaac tatactgctg gttccttttc
    11641 aaaacgtttt ggtgtggatg agggaatcgc cttggagact ccgattgtcg aattttacta
    11701 caaaaatgat gatttggatg atccatttat caatgatgag catgtgaaat tcctacagat
    11761 tgcgggtgac cagcagattg cctacttgaa ggaagaaacg cgtcgtatca atgaactatt
    11821 gaaagtctgg tttgctgaga ttgggcttaa attgattgac tttaagctag agttcggttt
    11881 tgacaaggat ggcaagatta tcttggcaga cgaattttca ccagataact gccgcttgtg
    11941 ggacgctgat ggcaaccaca tggataagga tgttttccgt agaggattgg gagaactaac
    12001 cgacgtttat gagattgttt gggaaaagtt gcagggttta aaataacaac ctcaaggctg
    12061 tttgggaata ttgcaagagc tgaaataaag gaataagaat tgatggataa acgtattttt
    12121 gttgaaaaaa aggttgattt tcaggtcaag tcagagagtt tggttagaga gctccagcac
    12181 aacttgggac tgtcaagctt gaaaagtatt cgtattgtgc aagtatatga tgtatttgac
    12241 ttgactgagg acttgtttgt acctgcagag aagcacattt tctctgagca ggtaaccgac
    12301 catgttttag atgaagtatc tgtgcaggcg gatcttgcta actatgcttt ctttgccatt
    12361 gaaagtctgc cagggcagtt tgaccagcgt gcagcttcgt cacaggaagc cttgcttttg
    12421 ttgggaagtt cgagtgacgt gacagtcaac acagcccaac tttacttggt gaataaagat
    12481 attgatgcga ctgagttgga agctgtcaaa aactacctgc tcaatccagt tgattctcgt
    12541 ttcaaggata tcacgacagg gattgctaag caggagtttt cagagtcaga caagaccatt
    12601 ccaaaattga ctttctttga aagctataca gcagaagact ttgctcgcta caaggccgag
    12661 caagggatgg ccatggaagt ggatgatttg ctctttatcc aagactactt taagtcaatc
    12721 gggcgcgtgc caactgagac tgaactcaag gttttggaca cttactggtc tgaccactgc
    12781 cgtcatacga cttttgagac agagttgaaa cacatcgact tttcagcttc taaatttcaa
    12841 aagcaattgc agtcaaccta tgacaagtat attgccatgc gcgaggaatt aggtcggtct
    12901 gaaaaaccac aaaccttgat ggatatggcg actattttcg gtcgttatga gcgtgctaat
    12961 ggacgattgg atgatatgga agtctctgac gaaatcaatg cctgctcagt tgaaattgaa
    13021 gtggacgttg atggtgtcaa ggaaccttgg ctcctcatgt ttaaaaacga aacccacaac
    13081 catccaacag aaattgagcc atttggtgga gcggctacct gtatcggtgg agctattcgt
    13141 gatccgttgt caggccgttc ctatgtttac caagccatgc gtatttcagg tgctggtgat
    13201 attacagcac cgatttcgga aactcgtgct gggaaattgc cacaacaagt catttctaaa
    13261 acagcaactc atggttattc ttcatatggt aaccagattg ggcttgccac aacctacgtt
    13321 cgtgaatact tccacccagg ctttgtagct aaacgtatgg aacttggtgc cgttgttggt
    13381 gcggctccca agggcaatgt tgtccgtgaa aaacctgaag caggtgatgt gatcatcctt
    13441 ctcggaggca aaacaggtcg tgatggtgtc ggtggtgcga cgggctcttc taaggttcaa
    13501 acagttgagt ctgtagagac tgctggtgct gaggttcaaa aaggaaatgc catcgaagaa
    13561 cgcaagattc agcgcctctt ccgtaatggc aatgtcactc gtctgatcaa gaagtccaat
    13621 gactttgggg caggcggcgt ctgtgtggct atcggtgaat tggcagacgg tcttgaaatc
    13681 gacctcaaca aggtgcctct taaataccag ggcttgaatg gtacagaaat tgccatctct
    13741 gaatcacaag aacggatggc ggtcgtggtt cgtcctgaag atgtggatgc cttcgttgcc
    13801 gaatgtaaca aagaaaatat tgatgctgtt gtggtggcga cagtaactga aaaaccaaat
    13861 cttgtcatgc actggaatgg tgagacaatc gttgacttgg agcgtcgttt ccttgacacc
    13921 aatggtgtgc gcgtggttgt cgatgccaaa gttgtggaca aggatgtcaa actcccagaa
    13981 gagcgtcaaa catctgctga aacactggaa gcagataccc ttacggttct atctgacctc
    14041 aaccatgcga gtcaaaaagg attacagact atctttgact gctctgttgg acgctcaacg
    14101 gttaatcacc cacttggtgg tcgttaccaa ctcacaccaa ctgaggcatc tgtgcagaaa
    14161 ttgccagttc aacacggtgt gactcatact gcgtcggtca ttgctcaagg tttcaaccca
    14221 tatgtagctg aatggtctcc ataccacggt gctgcttatg cggttatcga agcaactgct
    14281 cgtttggtgg ctgctggtgc caactggtct aaggctcgtt tctcttacca agaatatttc
    14341 gagcggatgg acaagcaagc agagcgtttt ggtcagccag tagccgccct tctaggctct
    14401 attgaagcac aaattcagct tggcttgcca tctatcggtg gtaaggactc catgtctggt
    14461 acctttgaag aattgaccgt tccgccaacc ttggttgcct ttggggtgac gacggcagat
    14521 agccgtaagg tgctctctcc agaatttaaa gctgttgggg aaaatatcta ctacatccca
    14581 ggtcaagccc tctctgcaga gattgatttt gacttgatta agaaaaattt tactcagttt
    14641 gaagccatcc aagctgacca taaagtgaca tctgcatcag ctgtcaaata cggtggtgta
    14701 gttgaaagtt tggctcttgc tacctttgga aactatattg gtgcagaggt gaccttgcct
    14761 gaacttaaaa cagctttgac agctcaatta ggcggctttg tcttcac
//
