LOCUS       NZ_CP097721            26293 bp    DNA     circular CON 09-JAN-2024
DEFINITION  Escherichia coli strain MS1665 chromosome, complete genome.
ACCESSION   NZ_CP097721
VERSION     NZ_CP097721.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 4724194)
  AUTHORS   Jia,L., Devkota,P., Arick,M.A. II, Hsu,C.-Y., Peterson,D.G.,
            Evans,J.D., Sukumaran,A.T. and Zhang,L.
  TITLE     Complete genome sequence of six multidrug resistance avian
            pathogenic Escherichia coli strains isolated from broilers
            exhibiting colibacillosis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4724194)
  AUTHORS   Jia,L., Devkota,P., Arick,M.A. II, Hsu,C.-Y., Peterson,D.G.,
            Evans,J.D., Sukumaran,A.T. and Zhang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-MAY-2022) Poultry Science, Mississippi State
            University, 46 Old Bully Blvd, 100 Hill Poultry Science Building,
            Mississippi State, MS 39762, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 2.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 438.4x
            Sequencing Technology :: Oxford Nanopore GridION; Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/09/2024 05:20:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,757
            CDSs (total)                      :: 4,638
            Genes (coding)                    :: 4,479
            CDSs (with protein)               :: 4,479
            Genes (RNA)                       :: 119
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 159
            CDSs (without protein)            :: 159
            Pseudo Genes (ambiguous residues) :: 0 of 159
            Pseudo Genes (frameshifted)       :: 66 of 159
            Pseudo Genes (incomplete)         :: 99 of 159
            Pseudo Genes (internal stop)      :: 48 of 159
            Pseudo Genes (multiple problems)  :: 46 of 159
            Pseudo Genes (short protein)      :: 2 of 159
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:34:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2921629
            Orig. end                         :: 2947922
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP097721.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26293
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..26293
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26293
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16293](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16293
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(50..2314)
                     /gene="ycaI"
                     /locus_tag="M9O79_RS14235"
                     /old_locus_tag="M9O79_14240"
     CDS             complement(50..2314)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030420 - establishment of competence for
                     transformation [Evidence IEA]"
                     /codon_start=1
                     /gene="ycaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309023.2"
                     /locus_tag="M9O79_RS14235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14240"
                     /product="ComEC family protein"
                     /protein_id="WP_000705700.1"
                     /transl_table=11
                     /translation="MKITTVGVCIICGIFPLLILPQLPGTLTLAFLTLFACVLAFIPVK
                     TVRYIALTLLFFVWGILSAKQILWAGETLTGATQDAIVEITATDGMTTHYGQITHLQGR
                     RIFPAPGLVLYGEYLPQAVCAGQQWSMKLKVRAVHGQLNDGGFDSQRYAIAQHQPLTGR
                     FLQASVIEPNCSLRAQYLASLQTTLQPYMWNAVILGLGMGERLSVPKEIKNIMRDTGTA
                     HLMAISGLHIAFAALLAAGLIRGGQVYLPGRWIHWQMPLIGGICCAAFYAWLTGMQPPA
                     LRTVVALATWGMLKLSGRQWSGWDVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFW
                     YQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGISLTSFIANLLAIPLVT
                     FITVPLILAAMVVHLSGPLILEQGLWFLADRSLALLFWGLKSLPEGWINIAERWQWLSF
                     SPWFLLVVWRLNAWRTLPAMCVAVGLLMCWPLWQKPRPDEWQVYMLDVGQGLAMVIARN
                     GKAILYDTGLAWPEGDSGQQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSILHTWPML
                     WIRSPLNWEHHQPCVRGEAWQWQGLRFSVHWPLQASNDKGNNHSCVVKVDDGTNSILLT
                     GDIEVPAEQKMLSRYWQQVQTTLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWR
                     LPSNKVKHRYQQQGYQWLDTPHQGQVTVNFSAQGWRISSLREQILPRWYHQWFGVPVDN
                     G"
     gene            complement(2521..2805)
                     /gene="ihfB"
                     /locus_tag="M9O79_RS14240"
                     /old_locus_tag="M9O79_14245"
     CDS             complement(2521..2805)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0006417 - regulation of translation
                     [Evidence IEA]"
                     /GO_process="GO:0075713 - establishment of integrated
                     proviral latency [Evidence IEA]"
                     /codon_start=1
                     /gene="ihfB"
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006819309.1"
                     /locus_tag="M9O79_RS14240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14245"
                     /product="integration host factor subunit beta"
                     /protein_id="WP_000167336.1"
                     /transl_table=11
                     /translation="MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEI
                     RGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG"
     gene            complement(2965..4638)
                     /gene="rpsA"
                     /locus_tag="M9O79_RS14245"
                     /old_locus_tag="M9O79_14250"
     CDS             complement(2965..4638)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005123560.1"
                     /locus_tag="M9O79_RS14245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14250"
                     /product="30S ribosomal protein S1"
                     /protein_id="WP_000140327.1"
                     /transl_table=11
                     /translation="MTESFAQLFEESLKEIETRPGSIVRGVVVAIDKDVVLVDAGLKSE
                     SAIPAEQFKNAQGELEIQVGDEVDVALDAVEDGFGETLLSREKAKRHEAWITLEKAYED
                     AETVTGVINGKVKGGFTVELNGIRAFLPGSLVDVRPVRDTLHLEGKELEFKVIKLDQKR
                     NNVVVSRRAVIESENSAERDQLLENLQEGMEVKGIVKNLTDYGAFVDLGGVDGLLHITD
                     MAWKRVKHPSEIVNVGDEITVKVLKFDRERTRVSLGLKQLGEDPWVAIAKRYPEGTKLT
                     GRVTNLTDYGCFVEIEEGVEGLVHVSEMDWTNKNIHPSKVVNVGDVVEVMVLDIDEERR
                     RISLGLKQCKANPWQQFAETHNKGDRVEGKIKSITDFGIFIGLDGGIDGLVHLSDISWN
                     VAGEEAVREYKKGDEIAAVVLQVDAERERISLGVKQLAEDPFNNWVALNKKGAIVTGKV
                     TAVDAKGATVELADGVEGYLRASEASRDRVEDATLVLSVGDEVEAKFTGVDRKNRAISL
                     SVRAKDEADEKDAIATVNKQEDANFSNNAMAEAFKAAKGE"
     gene            complement(4749..5432)
                     /gene="cmk"
                     /locus_tag="M9O79_RS14250"
                     /old_locus_tag="M9O79_14255"
     CDS             complement(4749..5432)
                     /EC_number="2.7.4.25"
                     /GO_function="GO:0004127 - cytidylate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /gene="cmk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125007.1"
                     /locus_tag="M9O79_RS14250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14255"
                     /product="(d)CMP kinase"
                     /protein_id="WP_000125016.1"
                     /transl_table=11
                     /translation="MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLAL
                     AALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVA
                     AFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQ
                     EKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQ
                     KLALA"
     gene            complement(5605..6369)
                     /gene="ycaL"
                     /locus_tag="M9O79_RS14255"
                     /old_locus_tag="M9O79_14260"
     CDS             complement(5605..6369)
                     /codon_start=1
                     /gene="ycaL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_706828.2"
                     /locus_tag="M9O79_RS14255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14260"
                     /product="metallopeptidase YcaL"
                     /protein_id="WP_001295345.1"
                     /transl_table=11
                     /translation="MKNTKLLLAIATSAALLTGCQNTHGIDTNMAISSGLNAYKAATLS
                     DADAKAIANQGCAEMDSGNQVASKSSKYGKRLAKIAKALGNNINGTPVNYKVYMTSDVN
                     AWAMANGCVRVYSGLMDMMNDNEIEGVLGHELGHVALGHSLAEMKASYAIVAARDAISA
                     TSGVASQLSRSQLGDIAEGAINAKYSRDKESEADDFSFDLLKKRGISTQGLVGSFEKLA
                     SLDGGRTQSMFDSHPPSTERAQHIRDRIASGK"
     gene            complement(6538..7821)
                     /gene="aroA"
                     /locus_tag="M9O79_RS14260"
                     /old_locus_tag="M9O79_14265"
     CDS             complement(6538..7821)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309018.1"
                     /locus_tag="M9O79_RS14260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14265"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_000445231.1"
                     /transl_table=11
                     /translation="MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLL
                     DSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAA
                     ALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVD
                     VDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQ
                     FVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLE
                     KMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVK
                     ETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDT
                     PVTILDPKCTAKTFPDYFEQLARISQAA"
     misc_feature    complement(7783..7797)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(7892..8980)
                     /gene="serC"
                     /locus_tag="M9O79_RS14265"
                     /old_locus_tag="M9O79_14270"
     CDS             complement(7892..8980)
                     /EC_number="2.6.1.52"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0004648 -
                     O-phospho-L-serine:2-oxoglutarate aminotransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006564 - L-serine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (3-350). E-value: 1.3e-73.
                     Score: 240.0. Matches aSDomain:
                     nrpspksdomains_M9O79_RS14265_Aminotran_5.1"
                     /codon_start=1
                     /gene="serC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_706825.1"
                     /locus_tag="M9O79_RS14265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14270"
                     /product="3-phosphoserine/phosphohydroxythreonine
                     transaminase"
                     /protein_id="WP_000057149.1"
                     /sec_met_domain="Aminotran_5 (E-value: 9.2e-77, bitscore:
                     256.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQIFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKE
                     FIQVAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAA
                     SAIKEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETP
                     DFGKDVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIAC
                     PSILDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVID
                     NSDFYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYN
                     AMPLEGVKALTDFMVEFERRHG"
     aSDomain        complement(7931..8971)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M9O79_RS14265_Aminotran_5.1"
                     /evalue="1.30E-73"
                     /label="M9O79_RS14265_Aminotran_5.1"
                     /locus_tag="M9O79_RS14265"
                     /protein_end="350"
                     /protein_start="3"
                     /score="240.0"
                     /tool="antismash"
                     /translation="IFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQ
                     VAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAI
                     KEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETPDFG
                     KDVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSI
                     LDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVIDNSD
                     FYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYNAMP
                     LEGVKAL"
     gene            complement(9179..9871)
                     /gene="ycaP"
                     /locus_tag="M9O79_RS14270"
                     /old_locus_tag="M9O79_14275"
     CDS             complement(9179..9871)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene="ycaP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415426.1"
                     /locus_tag="M9O79_RS14270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14275"
                     /product="DUF421 domain-containing protein"
                     /protein_id="WP_000642849.1"
                     /transl_table=11
                     /translation="MKAFDLHRMAFDKVPFDFLGEVALRSLYTFVLVFLFLKMTGRRGV
                     RQMSLFEVLIILTLGSAAGDVAFYDDVPMVPVLIVFITLALLYRLVMWLMAHSEKLEDL
                     LEGKPVVIIEDGELAWSKLNNSNMTEFEFFMELRLRGVEQLGQVRLAILETNGQISVYF
                     FEDDKVKPGLLILPSDCTQRYKVVPESADYACIRCSEIIHMKAGEKQLCPRCANPEWTK
                     ASRAKRVT"
     gene            10001..11761
                     /gene="ycaO"
                     /locus_tag="M9O79_RS14275"
                     /old_locus_tag="M9O79_14280"
     CDS             10001..11761
                     /codon_start=1
                     /gene="ycaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415425.4"
                     /locus_tag="M9O79_RS14275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14280"
                     /product="30S ribosomal protein S12 methylthiotransferase
                     accessory factor YcaO"
                     /protein_id="WP_001297197.1"
                     /sec_met_domain="YcaO (E-value: 1.7e-79, bitscore: 265.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQTFIPGKDAALEDSIARFQQKLSDLGFQIEEASWLNPVPNVWS
                     VHIRDKECALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGETIANGPFVHYP
                     NEKWFPLTENDDVPEGLLDDRLRAFYDPENELTGSMLIDLQSGNEDRGICGLPFTRQSD
                     NQTVYIPMNIIGNLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESISLPEIPAD
                     VLARYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFG
                     VALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLISWDLFKQDAD
                     YPFVDWNFSGTTEEEFATLMAIFKKEDKEVYIADYEHLGVYACRIIVPGMSDIYPAEDL
                     WLANNSMGSHLRETILSLPGSEWEKEDYLNLIEQLDEEGFDDFTRVRELLGLATGSDNG
                     WYTLRIGELKAMLALAGGDLEQALVWTEWTMEFNSSVFSPERANYYRCLQTLLLLAQEE
                     DRQPLQYLNAFVRMYGADAVEAASAAMSGEAAFYGLQPVDSDLHAFAAHQSLLKAYEKL
                     QRAKAAFWAK"
     misc_feature    11857..11870
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 20.12"
                     /tool="antismash"
     misc_feature    11865..11882
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.81"
                     /tool="antismash"
     gene            12167..13024
                     /gene="focA"
                     /locus_tag="M9O79_RS14280"
                     /old_locus_tag="M9O79_14285"
     CDS             12167..13024
                     /codon_start=1
                     /gene="focA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309014.1"
                     /locus_tag="M9O79_RS14280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14285"
                     /product="formate transporter FocA"
                     /protein_id="WP_000642546.1"
                     /transl_table=11
                     /translation="MKADNPFDLLLPAAMAKVAEEAGVYKATKHPLKTFYLAITAGVFI
                     SIAFVFYITATTGTGTMPFGMAKLVGGICFSLGLILCVVCGADLFTSTVLIVVAKASGR
                     ITWGQLAKNWLNVYFGNLVGALLFVLLMWLSGEYMTANGQWGLNVLQTADHKVHHTFIE
                     AVCLGILANLMVCLAVWMSYSGRSLMDKAFIMVLPVAMFVASGFEHSIANMFMIPMGIV
                     IRDFASPEFWTAVGSAPENFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRE
                     NDHH"
     gene            13079..15361
                     /gene="pflB"
                     /locus_tag="M9O79_RS14285"
                     /old_locus_tag="M9O79_14290"
     CDS             13079..15361
                     /EC_number="2.3.1.54"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008861 - formate C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006113 - fermentation [Evidence IEA]"
                     /GO_process="GO:0015942 - formate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415423.1"
                     /locus_tag="M9O79_RS14285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14290"
                     /product="formate C-acetyltransferase"
                     /protein_id="WP_001292822.1"
                     /transl_table=11
                     /translation="MSELNEKLATAWEGFTKGDWQNEVNVRDFIQKNYTPYEGDESFLA
                     GATEATTTLWDKVMEGVKLENRTHAPVDFDTAVASTITSHDAGYINKQLEKIVGLQTEA
                     PLKRALIPFGGIKMIEGSCKAYNRELDPMIKKIFTEYRKTHNQGVFDVYTPDILRCRKS
                     GVLTGLPDAYGRGRIIGDYRRVALYGIDYLMKDKLAQFTSLQADLENGVNLEQTIRLRE
                     EIAEQHRALGQMKEMAAKYGYDISGPATNAQEAIQWTYFGYLAAVKSQNGAAMSFGRTS
                     TFLDVYIERDLKAGKITEQEAQEMVDHLVMKLRMVRFLRTPEYDELFSGDPIWATESIG
                     GMGLDGRTLVTKNSFRFLNTLYTMGPSPEPNMTILWSEKLPLNFKKFAAKVSIDTSSLQ
                     YENDDLMRPDFNNDDYAIACCVSPMIVGKQMQFFGARANLAKTMLYAINGGVDEKLKMQ
                     VGPKSEPIKGDVLNYDEVMERMDHFMDWLAKQYITALNIIHYMHDKYSYEASLMALHDR
                     DVIRTMACGIAGLSVAADSLSAIKYAKVKPIRDEDGLAIDFEIEGEYPQFGNNDPRVDD
                     LAVDLVERFMKKIQKLHTYRDAIPTQSVLTITSNVVYGKKTGNTPDGRRAGAPFGPGAN
                     PMHGRDQKGAVASLTSVAKLPFAYAKDGISYTFSIVPNALGKDDEVRKTNLAGLMDGYF
                     HHEASIEGGQHLNVNVMNREMLLDAMENPEKYPQLTIRVSGYAVRFNSLTKEQQQDVIT
                     RTFTQSM"
     gene            15553..16293
                     /gene="pflA"
                     /locus_tag="M9O79_RS14290"
                     /old_locus_tag="M9O79_14295"
     CDS             15553..16293
                     /EC_number="1.97.1.4"
                     /GO_function="GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309012.1"
                     /locus_tag="M9O79_RS14290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14295"
                     /product="pyruvate formate lyase 1-activating protein"
                     /protein_id="WP_000111043.1"
                     /sec_met_domain="Fer4_12 (E-value: 1.6e-18, bitscore: 65.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.7e-32, bitscore:
                     110.0, seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.1e-07, bitscore: 29.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVIGRIHSFESCGTVDGPGIRFITFFQGCLMRCLYCHNRDTWDT
                     HGGKEVTVEDLMKEVVTYRHFMNASGGGVTASGGEAILQAEFVRDWFRACKKEGIHTCL
                     DTNGFVRRYDPVIDELLEVTDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVK
                     VWIRYVVVPGWSDDDDSAHRLGEFTRDMGNVEKIELLPYHELGKHKWVAMGEEYKLDGV
                     KPPKKETMERVKGILEQYGHKVMF"
     gene            complement(16375..16965)
                     /gene="ycaK"
                     /locus_tag="M9O79_RS14295"
                     /old_locus_tag="M9O79_14300"
     CDS             complement(16375..16965)
                     /EC_number="1.6.99.-"
                     /codon_start=1
                     /gene="ycaK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415421.1"
                     /locus_tag="M9O79_RS14295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14300"
                     /product="NAD(P)H oxidoreductase"
                     /protein_id="WP_001190375.1"
                     /transl_table=11
                     /translation="MQSERIYLVWAHPRHDSLTAHIADAIHQRAMERKIQVTELDLYRR
                     NFNPVMTSEDEPDWKNMDKRYSPEVHQLYSELLEHDTLVVVFPLWWYSFPAMLKGYIDR
                     VWNNGLAYGDGHKLPFNKVRWVALVGGDKESFVQMGWEKNISDYLKNMCSYLGIEDADV
                     TFLCNTVVFDGEELHASYYQSLLSQVRDMVDAL"
     gene            17065..17973
                     /gene="ycaN"
                     /locus_tag="M9O79_RS14300"
                     /old_locus_tag="M9O79_14305"
     CDS             17065..17973
                     /codon_start=1
                     /gene="ycaN"
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415420.1"
                     /locus_tag="M9O79_RS14300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14305"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_001242680.1"
                     /transl_table=11
                     /translation="MRMNMSDFATFFAVARNQSFRAAGDELGLSSSAISHSIKTLEQRL
                     KIRLFNRTTRSVSLTEAGSNLYERLRPAFDEIQIMLDEMNDFRLTPTGTLKINAARVAA
                     RIFLMPLLVGFTREYPDIKVELTTDDSLVDIVQQGFDAGVRLSGIVEKDMISVAIGPPV
                     KLCVAATPEYFARYGKPRHPHDLLNYQCVVFRYPSGKPFHWQFAKELEIAVAGNIILDD
                     VDAELEAVLMGAGIGYLLYEQIKEYLDTGRLECVLEDWSTERPGFQIYYPNRQYMSCGL
                     RAFLDYVKTGQICQSQRHRPQ"
     gene            complement(17974..19404)
                     /gene="ycaM"
                     /locus_tag="M9O79_RS14305"
                     /old_locus_tag="M9O79_14310"
     CDS             complement(17974..19404)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ycaM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415419.2"
                     /locus_tag="M9O79_RS14305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14310"
                     /product="amino acid permease"
                     /protein_id="WP_000918506.1"
                     /transl_table=11
                     /translation="MAGNVQEKQLRWYNIALMSFITVWGFGNVVNNYANQGLVVVFSWV
                     FIFALYFTPYALIVGQLGSTFKDGKGGVSTWIKHTMGPGLAYLAAWTYWVVHIPYLAQK
                     PQAILIALGWAMKGDGSLIKEYSVVALQGLTLVLFIFFMWVASRGMKSLKIVGSVAGIA
                     MFVMSLLYVAMAVTAPAITEVHIATTNITWETFIPHIDFTYITTISMLVFAVGGAEKIS
                     PYVNQTRNPGKEFPKGMLCLAVMVAVCAILGSLAMGMMFDSRNIPDDLMTNGQYYAFQK
                     LGEYYNMGNTLMVIYAIANTLGQVAALVFSIDAPLKVLLGDADSKYIPASLCRTNASGT
                     PVNGYFLTLVLVAILIMLPTLGIGDMNNLYKWLLNLNSVVMPLRYLWVFVAFIAVVRLA
                     QKYKPEYVFIRNKPLAMTVGIWCFAFTAFACLTGIFPKMEAFTAEWTFQLALNVATPFV
                     LVGLGLIFPLLARKANSK"
     gene            complement(19614..20762)
                     /gene="ycaD"
                     /locus_tag="M9O79_RS14310"
                     /old_locus_tag="M9O79_14315"
     CDS             complement(19614..20762)
                     /codon_start=1
                     /gene="ycaD"
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309010.1"
                     /locus_tag="M9O79_RS14310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14315"
                     /product="MFS transporter"
                     /protein_id="WP_000109295.1"
                     /transl_table=11
                     /translation="MSTYTRPVMLLLSGLLLLTLAIAVLNTLVPLWLAQEHMSTWQVGV
                     VSSSYFTGNLVGTLLTGYVIKRIGFNRSYYLASFIFAAGCAGLGLMIGFWSWLAWRFVA
                     GVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVSTELMSVLPW
                     VTGLTLAGILPLLFTRVLNQQAENHDSTSITSMLKLRQARLGVNGCIISGIVLGSLYGL
                     MPLYLNHKGVSNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIA
                     MLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSF
                     TAMLMQNFSDNLLFIMIASVSFIYLLMLLRNAGHTPKPVAHV"
     gene            21077..21703
                     /gene="ycaC"
                     /locus_tag="M9O79_RS14315"
                     /old_locus_tag="M9O79_14320"
     CDS             21077..21703
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ycaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309009.1"
                     /locus_tag="M9O79_RS14315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14320"
                     /product="isochorismate family cysteine hydrolase YcaC"
                     /protein_id="WP_000165876.1"
                     /transl_table=11
                     /translation="MTKPYVRLDKNDAAVLLVDHQAGLLSLVRDIEPDKFKNNVLALGD
                     LAKYFNLPTILTTSFETGPNGPLVPELKAQFPDAPYIARPGNINAWDNEDFVKAVKATG
                     KKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAWDRMSQAGAQLM
                     TWFGVACELHRDWRNDIEGLATLFSNHIPDYRNLMTSYDTLTKQK"
     gene            complement(21739..22602)
                     /gene="dmsC"
                     /locus_tag="M9O79_RS14320"
                     /old_locus_tag="M9O79_14325"
     CDS             complement(21739..22602)
                     /EC_number="1.8.5.3"
                     /codon_start=1
                     /gene="dmsC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309008.1"
                     /locus_tag="M9O79_RS14320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14325"
                     /product="dimethyl sulfoxide reductase anchor subunit DmsC"
                     /protein_id="WP_000534648.1"
                     /transl_table=11
                     /translation="MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVI
                     ACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVGASALSNEIASGSIFFAVGGIGWLL
                     AMLKKLSPALRTLWLVVTMVLGVVFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFMGG
                     PLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVMSVMQGTELATIHSSVQQAAALVPD
                     YGALMSWRIVLLAVALCLWIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTV
                     GMAVAS"
     gene            complement(22604..23221)
                     /gene="dmsB"
                     /locus_tag="M9O79_RS14325"
                     /old_locus_tag="M9O79_14330"
     CDS             complement(22604..23221)
                     /codon_start=1
                     /gene="dmsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000213046.1"
                     /locus_tag="M9O79_RS14325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14330"
                     /product="dimethylsulfoxide reductase iron-sulfur subunit
                     DmsB"
                     /protein_id="WP_000213098.1"
                     /transl_table=11
                     /translation="MTTQYGFFIDSSRCTGCKTCELACKDYKDLTPEVSFRRIYEYAGG
                     DWQEDNGVWHQNVFAYYLSISCNHCEDPACTKVCPSGAMHKREDGFVVVDEDVCIGCRY
                     CHMACPYGAPQYNETKGHMTKCDGCYDRVAEGKKPICVESCPLRALDFGPIDELRKKHG
                     DLAAVAPLPRAHFTKPNIVIKPNANSRPTGDTTGYLANPKEV"
     gene            complement(23232..25676)
                     /gene="dmsA"
                     /locus_tag="M9O79_RS14330"
                     /old_locus_tag="M9O79_14335"
     CDS             complement(23232..25676)
                     /EC_number="1.8.5.3"
                     /GO_function="GO:0009389 - dimethyl sulfoxide reductase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030151 - molybdenum ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="dmsA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415414.4"
                     /locus_tag="M9O79_RS14330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M9O79_14335"
                     /product="dimethylsulfoxide reductase subunit A"
                     /protein_id="WP_000850306.1"
                     /transl_table=11
                     /translation="MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSALTLPFSRIAHA
                     VDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRAC
                     LRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESI
                     YLNYGTGTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWAD
                     GNSPSDIENSKLVVLFGNNPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGR
                     EDEWIPIRPGTDAALVNGLAYVMITENLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAY
                     ILGEGPDGVAKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATR
                     AISMLAILTGNVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEM
                     TALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMT
                     SSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKR
                     LGVEQQFTEGRTQEEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFR
                     EDPQANPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPLNKQYP
                     LQLTGFHYKSRVHSTYGNVDVLKAACRQEMWINPLDAQKRGINNGDKVRIFNDRGEVHI
                     EAKVTPRMMPGVVALGEGAWYDPDTKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVE
                     KV"
     misc_feature    25661..25675
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 20.65"
                     /tool="antismash"
     misc_feature    25847..25860
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
ORIGIN
        1 tgtcgttatg cattcaaaaa accagcattt gttgaaatag ccgcatattc tacccgttat
       61 ccactggcac gccaaaccac tgatgatacc aacgaggtaa aatttgctct ctgaggctgc
      121 taatccgcca gccttgcgct gaaaaattga ccgtcacttg accctgatgt ggagtatcaa
      181 gccattgata tccttgctgt tgatagcgat gcttaacttt attagagggc aatcgccatg
      241 cgttatagcg cgatgccgat gcgagtgcca cttttccatt cactcgctga attaatggca
      301 acgatgatga ggtattactg ccatggtgag gtacctgaag caatgttgtc tgcacttgct
      361 gccagtaacg gcttagcatc ttttgttcag cggggacttc aatatcaccg gttagaagaa
      421 tgctattcgt cccgtcatca accttaacca cacaggaatg gttatttcct ttatcgttgc
      481 tagcttgtaa aggccagtgc acgctgaaac gcaatccttg ccattgccac gcttcgccac
      541 gcacacaggg ctgatgatgt tcccagttta acggacttct gatccataac atcggccatg
      601 tgtgcaatat tgagtccagc cctccccggt gatccagatg ttcatgactc agaataacgc
      661 cttccggttc aagattatgc cagtggagcc aggggataat cagttgttgc ccactatccc
      721 cttcgggcca ggccagtcct gtgtcataga gaatcgcttt gccgtttctg gctatcacca
      781 ttgccagccc ttgcccgaca tcaagcatgt acacctgcca ctcgtcaggt cgaggttttt
      841 gccacagcgg ccagcacatc agcaagccta cagccacaca cattgctggc aacgttcgcc
      901 aggcgtttaa tcgccatacc accagtaaga accatgggga aaatgatagc cattgccaac
      961 gttcagcaat gttgatccac ccttctggca aactctttaa cccccagaaa agtaaagcca
     1021 aagaccggtc ggcaagaaac cataaccctt gctccaggat taacggcccg cttaaatgca
     1081 caaccatcgc ggcgaggatc aacggaaccg tgataaatgt caccaaggga attgctaata
     1141 gatttgcaat aaacgaggtc agactaatgc catgaaatat gacgatttgc acaggcataa
     1201 gcaggagtgt gattcccagt tgcaaatgaa tgagggaaac aactgcacgc aataccggcg
     1261 gcagttgcca ctcaggacag ggaaaccact ggtaccaaaa aatcagtgcc gcgaccgcag
     1321 cggcagagag ccataaactt tgcgagagaa tggcaacagg atccatcagc aaaattgccg
     1381 ccagacaaca tatccataca tcccagccac tccactgtcg cccacttaac ttaagcattc
     1441 cccacgtagc aagcgccacc acggtacgca atgcaggagg ttgcattccc gtcaaccagg
     1501 cataaaaagc agcacagcag attccaccaa ttaatggcat ttgccagtgg atccagcgcc
     1561 caggcagata aacttgccca ccgcgaatga gtccggcagc cagcaacgcc gcaaaagcga
     1621 tgtgcaatcc cgatatcgcc attaaatgcg ccgttccagt atcacgcatg atatttttga
     1681 tttctttggg gacggataac cgttccccca tacctaaacc aagaataacc gcattccaca
     1741 tatagggttg cagcgttgtt tgtagtgacg ccagatactg tgcacgcagg ctacaattcg
     1801 gttcaatgac acttgcctgc agaaagcggc cggtgagcgg ctgatgctgg gcaatggcat
     1861 aacgctggct atcaaagccg ccatcattaa gttggccatg aactgcacga actttgagtt
     1921 tcattgacca ttgttgtcca gcacaaaccg cttgcggaag atattcgcca tacagcacaa
     1981 ggcctggcgc agggaatata cgtcgacctt gtagatgagt aatttgaccg taatgagtgg
     2041 tcatgccgtc agttgcagtg atctcaacaa ttgcatcctg cgtcgcgcca gttaaggttt
     2101 ctcctgccca caaaatttgc tttgctgata atatgcccca aacgaaaaac agcaacgtca
     2161 gcgcgatata acggacggtt ttaacaggga taaatgccag tacgcaggcg aagagagtca
     2221 gaaacgcaag ggttaatgtc ccaggcaatt ggggcaaaat cagcaacgga aaaattccgc
     2281 aaattatgca tacgccgact gtcgttattt tcatacaccc ctccctgttt atggaaagtg
     2341 tgcaactttg ttgagcggtt gtctggtggg aattttgcgt tccccgaggc acattcagaa
     2401 gaatttaacg aaagggtgaa aactgctcaa aactctgcga ggcagcttcc agttcctgat
     2461 tagagaaatg aaaaaagcac ccgacaggtg cttttctcgc gttcaagttt gagtaaaaac
     2521 ttaaccgtaa atattggcgc gatcgcgcag ttctttacca ggtttaaagt gaggaacgta
     2581 ttttccttcc agttctactt tatcgccagt cttcggatta cgtccggtac gtggtgcgcg
     2641 gtagtgcaaa gagaaactgc cgaaaccgcg gatttcaata cgctcgccct gcgcaagagt
     2701 cgaggccata tgctccagca tctcttttac tgcatcttca accgtcttgg cgggaatgtg
     2761 cgattgctgg gtggcaagtc tttctatcaa ttctgacttg gtcatgattc ctccggttcc
     2821 ttaaaggcaa attaagcggc tgctgttgct gcattgatta agggcggccg tagccgccct
     2881 tagtgcttga ttacaggacg aaacctgcaa tctgtcaagt aaactcaaca aacttcggaa
     2941 taaaaatccc gaagagtcag agaattactc gcctttagct gctttgaaag cttcagccat
     3001 tgcgttgttg gagaagtttg catcttcctg tttgttaaca gttgcgattg catctttctc
     3061 gtcagcttcg tctttcgcac gaacagacag gctgattgcg cggtttttac gatcaacgcc
     3121 ggtgaattta gcttcaactt cgtcgccaac gctcagaacc agggtagcgt cttcaacgcg
     3181 gtcacgggat gcttcagaag cacgcaggta accttcaacg ccgtcagcca gttctacggt
     3241 tgcgccttta gcgtcaactg cagttacttt accggttacg atagcgcctt tcttgttcag
     3301 agcaacccag ttgttgaacg gatcttctgc gagctgttta acgcccaggg agatacgttc
     3361 acgttctgcg tcaacctgca gaacaactgc agcgatttcg tcgccttttt tgtattcacg
     3421 aactgcttct tcgcctgcaa cgttccagga gatgtcagac aggtgaacca ggccgtcgat
     3481 gccgccgtcc aggccgatga agataccgaa gtcagtgata gacttgattt taccttcaac
     3541 acggtcgccc ttgttgtggg tttccgcgaa ctgctgccac gggttagctt tgcactgttt
     3601 cagacccagg gagatacgac gacgttcttc gtcgatatcc agaaccataa cttccactac
     3661 atcgccaacg ttaacaactt tggacgggtg gatgtttttg ttggtccaat ccatttcgga
     3721 aacgtgtacc aggccttcaa cgccttcttc gatttcaacg aagcagccgt agtcggtcag
     3781 gttggtcacg cgaccagtca gtttggtacc ttccggataa cgtttagcga tagctaccca
     3841 cggatcttcg cccagctgtt tcaggcccag agatacacgg gtacgttcgc ggtcgaactt
     3901 cagcacttta acagtgattt cgtcgcccac gttgacgatt tcgctcggat gcttaacgcg
     3961 tttccaggcc atgtcagtga tgtgcagcag gccgtcaacg ccgcccagat caacgaatgc
     4021 accgtagtca gtgaggttct taacgatacc tttaacttcc atgccttcct gcaggttttc
     4081 cagcagctga tcgcgctctg cgctgttttc ggattcgata acggcacgac gagaaacaac
     4141 aacgttgttg cgcttctgat ccagcttgat tactttgaat tcaagctctt tgccttccag
     4201 gtgcagagtg tcacgcaccg gacgaacgtc taccagagaa cctggcagga acgcacgaat
     4261 accgttcagc tcaacagtga agccgccctt aactttgccg ttgataacac cggtaacagt
     4321 ttcagcatct tcgtaagctt tttccagcgt gatccaggct tcgtgacgtt tagctttctc
     4381 acgggacagc agagtttcac cgaagccgtc ttctactgcg tccagagcaa cgtcaacttc
     4441 gtcacctacc tggatttcca gctcgccctg ggcgtttttg aactgctcag ccgggatggc
     4501 ggactcagat ttcagaccag cgtcaaccag tactacgtct ttgtcgatag caacaacaac
     4561 gccacgaacg atagaacccg ggcgggtttc gatttctttt aaggactctt caaagagttg
     4621 agcaaaagat tcagtcatgt ttaatcttca ggtttatatt taacgtccac ctggctccat
     4681 gccggatggg gttgtttaac atacccgctg tcattccatt gcaacggggg tactgcaaat
     4741 tcggtcgctt atgcgagagc caatttctgg cgcgcgtatt gtagcgcttt ttcaatcact
     4801 tgctcaatgc ttaaggtggt ggaatccaac actaaagcat cggctgccgg aaccagtggc
     4861 gctaccgctc ggttacgatc gcggtcgtcg cgttctttga tctcggccaa aaggcgctca
     4921 aagttaacac taaagccctt ctcctgcaac tgtagcatgc ggcgatgcgc tcgttcttcc
     4981 gaggaggcgt caaggaaaat tttcactggc gcatcaggga ataccaccgt tcccatgtcg
     5041 cggccatcgg caatcaggcc tggtaattcg cgaaacgcgc gttggcgacg caataatgct
     5101 tcacgaacgc gtgggaatgc cgcgacttgt gaagctgcat tcgccacttc ctgagtacga
     5161 atttcgccgc tgacatcttc cccttcgagg atcacttcca gattgccatt ggttgacaca
     5221 aaacgtacat ccagatggga tgccagcggt accagcgcat cttctgacgc aacatcaaca
     5281 tggtgatgta atgccgccaa tgccagtacg cgataaattg cacccgaatc cagcagatgc
     5341 cattgcaatg cttccgccat agccttacac aaggtgcctt tccctgcacc gcttgggcca
     5401 tcaatggtaa taaccggggc aattgccgtc atctttatct ccttaaaaca ggcgtaccgt
     5461 taacataacc gcgcgcatta tacgcgccga cgccacaaat cgttaacgtt gtgtgcaaaa
     5521 accagttttg tctgtattca gatggggatt tattgcgcaa ttatagcggg ctggcagaag
     5581 accagcccga aagatgacaa tgatttactt accagaggcg atacgatcac ggatgtgttg
     5641 cgcacgctct gttgatggtg ggtgagagtc aaacatggac tgggtgcgac cgccatccag
     5701 actagccagt ttttcaaagc tgccaaccag cccctgggtg ctgatgccac gtttcttcaa
     5761 cagatcaaag gagaaatcat ctgcttcgga ctctttatca cgggagtatt tagcattaat
     5821 agcgccttct gcgatatcac ccaattgtga gcgggaaagc tgggaagcca ctccgctggt
     5881 agctgaaatg gcatcgcgtg cggcaacgat cgcataagaa gctttcattt cagccagcga
     5941 gtgacccaac gcgacgtggc ccagttcatg gcccagaaca ccttcaattt cgttgtcatt
     6001 catcatgtcc atcaggccac tgtagacacg gacacagccg ttcgccatcg cccatgcgtt
     6061 gacgtcgctg gtcatataaa ccttatagtt gaccggcgtg ccattaatat tgttacccaa
     6121 tgctttggcg atttttgcca gacgtttacc gtacttgctg gatttacttg cgacttgatt
     6181 gccgctgtcc atttcggcac agccctgatt ggcaatcgct tttgcatcgg catcgcttaa
     6241 tgttgctgct ttataggcat ttaaaccgga gctgatagcc atattggtat caataccgtg
     6301 ggtattttga caccctgtca gtaatgctgc agaggtcgca atcgccagca gtaatttagt
     6361 attcttcatg tgaatcatcc gttgattaat catatataaa tattatgtat caacaactta
     6421 cattgacaag cgacgctacc attaatcaaa atgactcaca aggtccgaaa aaaaacgccg
     6481 acaatgtgcc gacgttttga taaagaaaga tttggctatt tatcgcccgt tgttcattca
     6541 ggctgcctgg ctaatccgcg ccagctgctc gaaataatcc ggaaatgttt tggccgtgca
     6601 tttgggatca agaatcgtca ctggtgtatc tgacaacgcc accagcgaga aacacatcgc
     6661 catccggtga tcattgtatg tcgcgatctc ggcaaagttc agtttttccg gaggagtgat
     6721 acgaatgtaa tcgtgcccct cttccacttc cgcgccgact ttacgcagtt ctgttgccat
     6781 cgcaaacagg cgatcggtct ctttaacacg ccagttatag atattgcgca gcgtggtggt
     6841 gccttttgca aataacgccg ccgtggcaat ggtcatcgcc gcatcaggaa tatggttcat
     6901 atccatatca atagcgttca gttcaccacg cgtgcaggaa atataatcat cgccccagca
     6961 aatggtcgcg cccatttttt ccagcacatc agcaaagcga atatcaccct gcatactgtt
     7021 acgtccaata ccggtcactt ttacagtgcc gcctttgatt gctgctgctg ccagaaagta
     7081 agaagccgaa gatgcatcgc cttcgaccaa ataagtaccc ggagactgat aagactgccc
     7141 gccttttacg acaaattgtt gatagtgctg attttcaatt tcaacaccaa acgtcttcat
     7201 cagattgagt gtgatgtcga tataaggttt agaaaccaga tcgcctttaa tacgaatcac
     7261 cgtatcttcc ggcgcaagag gcgcagtcat taacagtgcg gtgaggaatt ggctggaaac
     7321 ggagccatca acgtcaacgt tgccgccagt aaagccgccc tgtaaacgca acggcggata
     7381 attttcttgt tccaggtaag tgatcttcgc cccgcccagg cgcagcgcat ccaccagatg
     7441 accaatcggg cgttctttca tacgcggctc accggtcagc acaatatcat tgctacccag
     7501 acaaagagct gccgccagcg gacgcattgc cgttccggcg ttaccgagga acaactccag
     7561 ggcaccttct gcgtgtaatg gaccgccgtt accgataatt tcgcaacgcg tacgatcggc
     7621 tgaaagcgta tagcttaccc ctaacgctgt taatgcattc agcatatggc gcacgtcatc
     7681 gctatccagc agattggtta atactgtttt gccgtgtgct aatgccgcca gcaataaagc
     7741 gcggttagaa acgctcttgg aaccgggcag attaatagtg ccatcgacac gagcgatggg
     7801 ttgtaacgtc agggattcca tgaactcaac tctctacaac agaaataaaa accccacagg
     7861 ctggctgtgg ggattaagca aaatttcggc attaaccgtg acggcgttcg aactcaacca
     7921 tgaagtctgt cagcgcttta acgccttcca gcggcatggc gttataaata gaagcgcgca
     7981 ttccgccgac cacacggtga cctttcagtg catgaaggcc agcagcaaaa gactcttcaa
     8041 ggaacaattt gtcaagcgca ctgtccgcca actggaacgg cacgttcatc cgcgaacggt
     8101 tagctttcgc cacgtcattg cggtagaaat cgctgttatc aatcacccca tatagcagtt
     8161 ctgctttttg ctgattgatt ttatccattt cagctacacc gccgttcgct ttcagccatt
     8221 taaagaccag accagataga taccaggcaa atgtcggcgg cgtgttaaac atggagccgt
     8281 tatcgttgag gatggaataa tccagaatcg acggacacgc gatattcgct ttgcccagca
     8341 aatcttcacg aacgatgacg attgtcaggc cagccgggcc gatatttttc tgcgcgccag
     8401 cgtaaatcac gccataacgg ctgacgtcaa tcggacggga aagaatggtt gaagagaagt
     8461 cggcggcgac caccacatct ttgccgaagt ctggcgtttc gtcgatggcg ataccgtcga
     8521 tggtttcatt cgggcagtaa tgcatataag cagcattatc agagagttgc cattcacgca
     8581 ttggcttaac cgcgcgcaga ccatcaacag tcactttggc gtcaaagaca ttaggcgtgc
     8641 agtatttttt cgcttcttta atggcacttg ccgcccagta accggcatca acataatctg
     8701 cggtggtttt atcaccgaga atattcagcg gtaccgcagc aaactgaccg cgaccaccgc
     8761 catggcagaa taataccttg tagttggagg ggacattaag aagatcgcga aaatccttct
     8821 cggcttcctc tgcaacctga atgaactctt tgccacggtg actcacttcc atcaccgacg
     8881 taccaagacc gttccagtcg cgcagttcct gttgagcctg tttaagcacc tctgccggta
     8941 gcattgccgg accagaacta aaattgaaga tttgagccat ttcccctcac cacgttgcgt
     9001 tgctattaac ccgcggtcaa tcgattgcga ccacaggtaa tacattattc ctgtggctat
     9061 cggttttatc attcagtgac acacatcgca atgagtaaaa ccgttgaggg caaaaatgtg
     9121 gcttgcatca cacaaaagaa tctctcggat tattagcaaa aagccgatgt ttttactgtc
     9181 aggtcacccg ttttgcccga cttgccttcg tccattctgg atttgcacag cgcggacata
     9241 attgtttttc ccccgctttc atatgaatga tttcactaca acgaatacag gcatagtccg
     9301 ccgactccgg caccactttg taacgctgcg tacaatcact gggtaaaata agtaaacccg
     9361 gtttcacctt gtcatcttca aagaaataga cactgatttg cccgttggtt tcgagaatcg
     9421 ccagacgtac ctgccccagc tgctccacgc cacgcaatcg tagctccata aagaactcaa
     9481 attccgtcat gttggagtta ttgagtttcg accaggccag ctcgccatct tcaataataa
     9541 caaccggctt accttccagt aaatcttcca gtttttcact gtgcgccatc aaccacatta
     9601 ccaggcggta taacaacgcc agagtgataa agacgataag taccggcacc atcggcacat
     9661 catcataaaa cgccacatct cccgccgctg aacccagcgt gagaatgatt aacacttcaa
     9721 acagcgacat ctgtcgcaca ccgcgtcttc cggtcatttt gaggaacaaa aaaaccagta
     9781 caaaggtata aagactacgt agtgcaactt cgccaaggaa atcaaaaggc actttatcaa
     9841 atgccatacg gtggagatcg aacgccttca tttttatgct cttatcgtgg tttatccgct
     9901 aaaagcatag tcaacagttc atcggcatgg cggcggtgat agcgcctttg agataaaacc
     9961 cgtattattg cgcgctttcc gtacgactaa agtgattttc atgacgcaaa catttatccc
    10021 cggcaaagat gccgctctgg aagattccat cgctcgcttc cagcaaaaac tttcagacct
    10081 cggctttcag attgaagagg cctcctggct gaatcctgtg cctaacgtct ggtctgtaca
    10141 tattcgcgac aaagagtgcg cactgtgttt taccaacggt aaaggcgcaa ccaaaaaagc
    10201 ggcgctggct tctgcacttg gtgaatattt cgagcgtctc tcaaccaact acttttttgc
    10261 tgatttctgg ctgggcgaaa ccatcgccaa cggtccgttc gtgcattatc ccaacgaaaa
    10321 atggttccca ctgaccgaaa atgacgatgt gccagaagga ctactcgatg accgtctgcg
    10381 cgcgttttat gatccggaga atgaactgac cggcagcatg ctgattgacc tacaatccgg
    10441 taacgaagat cgtggtattt gcggcctgcc gtttacgcgt cagtccgaca atcagaccgt
    10501 ttatattccg atgaatatca ttggtaacct gtacgtctcc aacggtatgt ccgcaggtaa
    10561 tacccgcaac gaagcacgcg ttcagggatt gtctgaagtt ttcgaacgct acgtgaaaaa
    10621 ccgcattatt gctgaaagca tcagcctgcc agagatcccg gcagacgtgc tggcgcgtta
    10681 cccagcagta gttgaagcca tcgaaacgct ggaagcggag ggtttcccaa tcttcgctta
    10741 tgacggttcg cttggcggcc agtatccggt gatttgcgtg gtactgttca atcctgctaa
    10801 cggtacctgc tttgcctctt tcggtgcgca tcctgatttt ggcgtagcac tggaacgtac
    10861 cgtgaccgag ctgctgcaag gtcgtggcct gaaagatttg gatgtgttta ctccgccaac
    10921 cttcgatgat gaagaagtcg ctgaacatac caacctcgaa acgcacttta tcgattccag
    10981 cggtttaatc tcctgggacc tgttcaagca ggatgccgat tatccgtttg tggactggaa
    11041 tttctccggc accacggaag aagagttcgc cacgctgatg gctatcttca aaaaggaaga
    11101 taaagaagtt tatattgccg attacgagca tctgggtgtc tacgcttgcc gcattatcgt
    11161 gcctggcatg tccgatattt atccggctga agatctgtgg ctcgcgaata acagtatggg
    11221 cagccattta cgtgaaacga ttctttcgct accaggcagc gagtgggaaa aagaagatta
    11281 cctgaacctc atcgagcaac tggatgaaga aggttttgat gactttaccc gcgtgcgtga
    11341 gctgttgggt ctggcgaccg ggtcggataa cggttggtac accctgcgta tcggtgaatt
    11401 aaaagccatg ctggcgctgg ctggtggcga tctggaacag gctctggtct ggaccgaatg
    11461 gacgatggag tttaactcat cagtatttag tccggaacgc gccaactatt atcgctgcct
    11521 gcaaacgttg ttattactgg cacaggaaga agatcgccag ccgctgcaat atctgaatgc
    11581 gtttgttcgc atgtacggcg cagatgccgt agaagccgcc agtgcggcaa tgagcggcga
    11641 agcggcgttt tacggcctgc aaccggtaga tagcgatctg cacgcgtttg ctgcacatca
    11701 gtcgttgttg aaggcctacg aaaagctgca gcgcgccaaa gcagcattct gggcaaaata
    11761 aaatcaaata gcctacgcaa tgtaggctta atgattagtc tgagttatat tacggggcgt
    11821 ttttttaatg ccccgcttta catatatttg cattaataaa ataattgtaa ttataaggtt
    11881 aaatatcggt aatttgtatt taataaatac gatcgatatt gttactttat tcgcctgatg
    11941 ctccctttta attaactgtt ttagcggagg atgcggaaaa aattcaactc atttgttaat
    12001 ttttaaaatt tatttttatt tggataatca aatatttact ccgtatttgc ataaaaacca
    12061 tgcgagttac gggcctataa gccaggcgag atatgatcta tatcaatttc tcatctataa
    12121 tgctttgtta gtatctcgtc gccgacttaa taaagagaga gttagtgtga aagctgacaa
    12181 cccttttgat cttttacttc ctgctgcaat ggccaaagtg gccgaagagg cgggtgtcta
    12241 taaagcaacg aaacatccgc ttaagacttt ctatctggcg attaccgccg gtgttttcat
    12301 ctcaatcgca ttcgtcttct atatcacagc aaccactggc acaggcacaa tgcccttcgg
    12361 catggcaaaa ctggttggcg gcatttgctt ctctctgggg ctgattcttt gtgttgtctg
    12421 cggagccgat ctctttactt ccacagtgtt gattgttgtt gctaaggcga gtgggcgcat
    12481 cacctggggt cagttggcga aaaactggct aaatgtctat tttggcaacc tggtcggcgc
    12541 actgctgttt gtacttttaa tgtggctttc cggcgagtat atgaccgcaa atggtcaatg
    12601 gggactaaac gtcctacaaa ccgccgacca caaagtgcac catactttta ttgaggccgt
    12661 ctgccttggt atcctggcaa acctgatggt atgtctggca gtatggatga gttattctgg
    12721 ccgtagcctg atggacaaag cgttcattat ggtgctgccg gtcgcgatgt ttgttgccag
    12781 cggttttgag cacagtatcg caaacatgtt tatgatcccg atgggtattg taatccgcga
    12841 cttcgcatct ccggaattct ggaccgctgt cggttctgca ccggaaaatt tttctcacct
    12901 gaccgtgatg aatttcatca ctgataacct gattccggtt acgatcggca acattatcgg
    12961 tggtggtttg ttggttgggt tgacatactg ggtcatttac ctgcgtgaaa acgaccacca
    13021 ttaatggttg tcgaagtacg cagtaaataa aaaatccact taagaaggta ggtgttacat
    13081 gtccgagctt aatgaaaagt tagccacagc ctgggaaggt tttaccaaag gtgactggca
    13141 gaatgaagta aacgtccgtg acttcattca gaaaaactac actccgtacg agggtgatga
    13201 gtccttcctg gctggcgcta ctgaagcgac caccaccctg tgggacaaag taatggaagg
    13261 cgttaaactg gaaaaccgca ctcacgcgcc agttgacttt gacaccgctg ttgcttccac
    13321 catcacctct cacgacgcag gctacatcaa caagcagctt gagaaaatcg ttggtctgca
    13381 gactgaagct ccgctgaaac gtgctcttat cccgttcggt ggtatcaaaa tgatcgaagg
    13441 ttcctgcaaa gcgtacaacc gcgaactgga tccgatgatc aaaaaaatct tcactgaata
    13501 ccgtaaaact cacaaccagg gcgtgttcga cgtttacact ccggacatcc tgcgttgccg
    13561 taaatctggt gttctgaccg gtctgccaga tgcatatggc cgtggccgta tcatcggtga
    13621 ctaccgtcgc gttgcgctgt acggtatcga ctatctgatg aaagacaaac tggcacagtt
    13681 cacttctctg caggctgatc tggaaaacgg cgtaaacctg gaacagacta tccgtctgcg
    13741 cgaagaaatc gctgaacagc accgcgctct gggtcagatg aaagaaatgg ctgcgaaata
    13801 cggctacgac atctctggtc cggctaccaa cgctcaggaa gctatccagt ggacttactt
    13861 cggctacctg gctgctgtta agtctcagaa cggtgctgca atgtccttcg gtcgtacctc
    13921 caccttcctg gatgtgtaca tcgaacgtga cctgaaagct ggcaagatca ccgaacaaga
    13981 agcgcaggaa atggttgacc acctggtcat gaaactgcgt atggttcgct tcctgcgtac
    14041 tccggagtac gatgaactgt tctctggcga cccgatctgg gcaaccgaat ctatcggtgg
    14101 tatgggcctc gacggtcgta ccctggttac caaaaacagc ttccgtttcc tgaacaccct
    14161 gtacaccatg ggtccgtctc cggaaccgaa catgaccatt ctgtggtctg aaaaactgcc
    14221 gctgaacttc aagaaattcg ccgctaaagt gtccatcgac acctcttctc tgcagtatga
    14281 gaacgatgac ctgatgcgtc cggacttcaa caacgatgac tacgctattg cttgctgcgt
    14341 aagcccgatg atcgttggta aacaaatgca gttcttcggt gcgcgtgcaa acctggcgaa
    14401 aaccatgctg tacgcaatca acggcggcgt tgacgaaaaa ctgaaaatgc aggttggtcc
    14461 gaagtctgaa ccgatcaaag gcgatgtcct gaactatgat gaagtgatgg agcgcatgga
    14521 tcacttcatg gactggctgg ctaaacagta catcactgca ctgaacatca tccactacat
    14581 gcacgacaag tacagctacg aagcctctct gatggcgctg cacgaccgtg acgttatccg
    14641 cactatggcg tgtggtatcg ctggtctgtc cgttgctgct gactccctgt ctgcaatcaa
    14701 atatgcgaaa gttaaaccga ttcgtgacga agacggtctg gctatcgact tcgaaatcga
    14761 aggcgaatac ccgcagtttg gtaacaatga tccgcgtgta gatgacctgg ctgttgacct
    14821 ggtagaacgt ttcatgaaga aaattcagaa actgcacacc taccgtgacg ctatcccgac
    14881 tcagtctgtt ctgaccatca cttctaacgt tgtgtatggt aagaaaactg gtaacacccc
    14941 agacggtcgt cgtgctggcg cgccgttcgg accgggtgct aacccgatgc acggtcgtga
    15001 ccagaaaggt gctgtagcgt ctctgacttc cgttgctaaa ctgccgtttg cttacgctaa
    15061 agatggtatc tcctacacct tctctatcgt tccgaacgca ctgggtaaag acgacgaagt
    15121 tcgtaagacc aacctggctg gtctgatgga tggttacttc caccacgaag catccatcga
    15181 aggtggtcag cacctgaacg ttaacgtgat gaaccgtgaa atgctgctcg acgcgatgga
    15241 aaacccggaa aaatatccgc agctgaccat ccgtgtatct ggctacgcag tacgtttcaa
    15301 ctcgctgact aaagaacagc agcaggacgt tattactcgt accttcactc aatctatgta
    15361 attagatttg actgaaatcg tacagtaaaa agcgtacaat aaaggctcca cgaaagtggg
    15421 gcctttttta gcacgagagc cttttttgtc agctatctat actttaaggt gactgccaaa
    15481 acagactcga cgtagccttc gagctgcgca ccaacacggc ctcagatggg ccacatctgg
    15541 agaaacaccg caatgtcagt tattggtcgc attcactcct ttgaatcctg tggaaccgta
    15601 gacggcccag gtattcgctt tatcaccttt ttccagggct gcctgatgcg ctgcctgtat
    15661 tgtcataacc gcgacacctg ggatacgcat ggcggtaaag aagttaccgt tgaagattta
    15721 atgaaagagg tggtgaccta tcgccacttt atgaacgctt ccggcggcgg cgttaccgca
    15781 tccggcggtg aggcaatcct acaagctgag tttgttcgtg actggttccg cgcctgcaaa
    15841 aaagaaggca ttcatacctg tctggacacc aacggttttg ttcgtcgtta cgatccggtg
    15901 attgatgaac tgctggaagt aaccgacctg gtaatgctcg atctcaaaca gatgaacgac
    15961 gagatccacc aaaatctggt tggagtttcc aatcaccgca cgctggagtt cgccaaatat
    16021 ctggcgaaca aaaatgtgaa ggtgtggatc cgctacgttg ttgtcccagg ctggtctgac
    16081 gatgacgatt cagcgcatcg cctcggtgaa tttacccgtg atatgggcaa cgttgagaaa
    16141 atcgagcttc tcccctacca cgagctgggc aaacacaaat gggtggcaat gggtgaagag
    16201 tacaaactcg acggtgttaa accaccgaag aaagagacca tggaacgcgt gaaaggcatt
    16261 cttgagcagt acggtcataa ggtaatgttc taatttcccc gtaaagcggc aactttattg
    16321 agttgccgct tttttattcc gcgcttcatt ctgctacagc gtttttaaca catcttatag
    16381 tgcatctacc atatcccgta cctgagataa taacgactga taatagctcg cgtgaagttc
    16441 ttccccatcg aataccactg tattacacaa gaaagtgaca tcggcatctt caataccaag
    16501 ataactgcac atatttttta aataatcgct tatatttttt tcccagccca tctggacaaa
    16561 tgattctttg tctcctccaa ccagcgccac ccaacgaact ttattgaatg gtaatttgtg
    16621 cccatctcca taagccagcc cattattcca tactctgtca atatatcctt ttagcattgc
    16681 cgggaagctg taccaccaga gaggaaaaac caccactaac gtgtcatgct caagcagctc
    16741 tgaataaagc tgatgaacct ctggagaata acgtttatcc atattcttcc agtctggttc
    16801 atcttccgac gtcatcaccg ggttgaaatt acgccgatat aaatcgagtt ccgtcacctg
    16861 tattttccgc tccattgccc gctgatggat cgcatcagca atatgtgcgg tcaatgaatc
    16921 atgacgagga tgggcccata ccaaataaat acgttcagac tgcataattt tacctccacg
    16981 ttaagttctg gagcgcactt tacgcaggcg gcataatcct gtaaacgtga tgattcagga
    17041 tgagttaatg aaggattttc actaatgcgg atgaatatgt ctgactttgc cactttcttt
    17101 gccgtggccc gtaatcaaag ctttcgtgca gcgggcgatg aattaggctt atcctcgtcc
    17161 gccattagcc atagtattaa aacactggaa caacgtctta aaattcgctt attcaatcgg
    17221 acaacccgaa gcgtatcgtt aacggaagcg ggttctaatc tctatgaacg attgcgccca
    17281 gctttcgacg aaattcagat catgttagat gagatgaatg attttcgtct gacaccgaca
    17341 ggaacgctca aaatcaatgc cgcccgggta gctgcacgta tatttttaat gcctttactg
    17401 gttggtttca cacgtgaata tcctgatatt aaagtcgagc tcacaactga cgattctctt
    17461 gtcgatatcg tccaacaggg ctttgacgct ggcgttcgac ttagtggcat cgtcgaaaaa
    17521 gatatgatca gcgtggcgat cggcccacca gtgaaattat gtgtagcagc aacgccagag
    17581 tactttgcaa gatatggcaa accccgccat cctcatgatc tgcttaatta tcaatgtgtt
    17641 gtttttcgtt atcccagcgg caaacctttc cactggcaat ttgcaaagga gctggaaatt
    17701 gctgtcgcag gaaatatcat tctggatgat gttgatgctg aactggaggc cgttttgatg
    17761 ggtgctggta tcgggtatct gctctatgaa cagatcaagg agtaccttga tactggtcgt
    17821 ttagaatgtg tactggaaga ctggagcaca gagcgtccag gcttccagat ctattatcca
    17881 aaccgccagt atatgtcctg cggcttgcgc gcatttctcg attatgtaaa aacgggtcag
    17941 atctgccaga gtcagcgtca ccgaccacaa taattattta ctattcgctt tacgcgccag
    18001 cagcgggaaa atcagtccta atcctaccag cacaaacggc gttgcaacat tcagcgccaa
    18061 ctggaaggtc cactctgcag tgaaggcttc cattttcggg aagatccccg tcaaacaggc
    18121 aaaggcggta aaggcaaaac accaaatccc gacggtcatt gccagaggct tattacgaat
    18181 aaagacatat tctggtttat atttctgcgc caggcgaacg actgcaataa atgcaacaaa
    18241 tacccataaa taacgcagcg gcatcactac cgagttaaga ttcaacagcc atttatagag
    18301 attgttcata tcaccgatgc cgagagtcgg cagcataatc agaattgcca ccagcaccag
    18361 ggtcagaaaa tagccattaa cgggcgtacc agaagcgttg gtacgacata aactggctgg
    18421 aatatatttg ctgtcagcat cacctaatag cactttaagc ggggcatcaa tcgagaatac
    18481 cagcgcagct acttgtccca gggtattcgc aatggcgtaa atcaccatta aagtattacc
    18541 catgttgtaa tactcgccca gcttctgaaa ggcgtaatat tgaccgttag tcattaagtc
    18601 atccgggata ttacgcgagt caaacatcat ccccatcgcc agtgagccca gaatggcaca
    18661 aaccgcaacc atcaccgcca ggcatagcat cccttttgga aattcttttc ctgggttgcg
    18721 cgtttgatta acgtaaggag aaatcttctc tgctccgcca accgcgaaaa ccagcattga
    18781 aatagtggta atgtaggtaa agtcgatatg aggaatgaac gtttcccagg taatgtttgt
    18841 ggtcgcaata tgcacttcag taatcgcagg cgcggttacc gccatcgcca catacaggag
    18901 cgacataaca aacatcgcaa tccctgccac agaaccgacg attttcagcg atttcatacc
    18961 gcgtgaagca acccacataa agaagataaa cagcaccagc gttaacccct gtaacgctac
    19021 gactgaatat tctttgatta gcgaaccgtc gcctttcatc gcccaaccga gcgcaatcag
    19081 aattgcctgg ggtttttgtg ccagataggg aatatgcacc acccagtagg tccacgcggc
    19141 gagataagcc agtccgggtc ccatcgtgtg tttaatccag gtactgaccc cgcccttccc
    19201 atctttgaag gtcgagccta actgaccaac aattagcgca taaggtgtga aatagagtgc
    19261 aaagataaac acccatgaaa aaacaaccac cagcccctgg ttggcatagt tattaacaac
    19321 gttgccaaaa ccccagacag tgataaaaga catcagcgca atgttgtacc atcgcaactg
    19381 tttttcctga acattcccag ccatagacaa atccttcgcc aaaattaaag gggcatctgt
    19441 aaaacgaggg attatgcgcg gcaaataaga agtgcggaaa tagcgaaatg caaaattata
    19501 acctgctgca cattttattt ttaaacgaat aaaatttgga ataaagcaag tcagatagaa
    19561 gaaacaaaaa agcagagtgt gaaacagtaa gttcacactc tgcttgaatt catttacacg
    19621 tgagcaacgg gtttcggcgt atgaccggcg ttgcgcagca gcatcagcaa atagataaac
    19681 gatacgctgg cgatcatgat aaacaataaa ttatcggaga aattctgcat tagcatagcg
    19741 gtaaatgacg ggccaagcag acttcccaca gtataactca acagtaaggc ctggttcatc
    19801 gccaccagtt gatgatgttc aactttctcg caagcccatg ccatcgccac cggatatagc
    19861 gtaaagccag cggcaccgag gatgaataac gctggggcca tcgccgcctg gctaagcatc
    19921 gcgatactgc cgagaatgac gacaaagacc tgaacacgca acaccagcag tcgaccaaac
    19981 ttatccgcca gacgtccaat cggccattgt ccaaggatac ccgcactgac cagtaccgcc
    20041 atccagaaac caatgctggc attgctcacc cctttgtgat tgaggtacag cggcatcagg
    20101 ccatatagag atcccagaac gattcctgag ataatgcagc cattcacgcc aagccgcgcc
    20161 tgacggagtt ttagcattga cgtaattgac gtcgaatcat ggttttcagc ctgctgattc
    20221 agcacacgcg taaacaacag cggtaagatc cctgccaacg tcaaacctgt aacccacggc
    20281 aatacggaca tcagctcggt tgaaactttg ctgaccagta actggcctaa aaacgttccc
    20341 acgtaataaa ccatcatata cgcagcaagc aaacgcccac ggttacgtga cgtcccactg
    20401 cacatcagcg cgctctcaac aaccacccaa atcatggcac agccgacgcc cgcgacaaaa
    20461 cgccaagcca accagctcca gaatccaatc atcaggccaa ggccggcaca gccagcggca
    20521 aaaatgaagg aggccagata atagctgcgg ttaaagccaa tgcgcttaat gacataccct
    20581 gtcagcaatg taccgacaag gttgccggta aaataggatg agctgacaac gcctacctgc
    20641 catgtggaca tgtgttcctg ggcgagccaa agcggcacga gtgtatttaa caccgcgatc
    20701 gccagagtca acaaaagcag gccagacagc aaaagcatga caggccgggt atacgtggac
    20761 atgaattaaa accgtgagga agttcaaatt tcatgcgcat catgccaccg ccaaaaacat
    20821 tgtcaatggg tgaaaatacg cgcatatcgc agcggcggta ttatcgattt atattactca
    20881 ttcataacgc taatgctgaa gagacgatta atctcatctg attgttttta ttgatctaac
    20941 acaaatttca tacgcttcgt tcagtcgaaa aatttcatgg tcacagcaaa ctcatatttc
    21001 ccgtctatgc tttcagagca atgcatcgcg tctgaccgat ttcagacgta ccactgactc
    21061 tcgaaaggag aagaggatga ccaaaccgta tgttcgtctt gataaaaatg atgctgccgt
    21121 tttgcttgtt gatcaccagg ctggtttact ttcccttgta cgggatatcg aacccgataa
    21181 gtttaaaaat aacgtgctgg cgctgggtga cctggctaag tatttcaact taccaactat
    21241 tcttaccacc agttttgaaa ccggtcctaa cggtccatta gttccagaac tgaaagcaca
    21301 attccccgat gcaccttaca ttgctcgccc gggaaatatt aacgcctggg ataacgaaga
    21361 ttttgtaaaa gcagtcaaag cgacaggtaa aaaacagtta attattgccg gtgtggtaac
    21421 cgaagtttgc gtggcattcc cggcgctttc agccattgaa gaagggtttg acgtctttgt
    21481 cgtgactgac gcgtcaggga cctttaatga aattacccgg cattcggcat gggatcgcat
    21541 gtcgcaagca ggtgcgcaat tgatgacatg gttcggcgtg gcgtgcgagc tgcaccgtga
    21601 ctggcgtaat gatattgaag gactggcgac gttgttctct aaccatattc ctgattatcg
    21661 taatttgatg accagttatg acacgttaac gaagcagaaa taaaagagaa ccggggccga
    21721 aaccccggtt gttactgatt agcttgcgac ggccatcccc acggtcatat gcaaaccata
    21781 gaatacgccg cgaccgatta attcccctgc cagaagcaga atgaatgaga cggatagtag
    21841 cggaaccgca ggctgataac cttttagctg tggtgcaatc cacaagcaca gggcaacggc
    21901 caaaagcacg atccgccagg acatcagcgc accatagtcc ggcaccagcg ctgcggcctg
    21961 ctgcacagaa ctatgaatag ttgccagctc tgtgccctgc atcactgaca tcacaccact
    22021 caccaccagt gccagtacag aaatggctgg cagcagacgc atcgcccagc catcgacgcc
    22081 agccagactc agcaacaggt aacccagtaa cgggccgccc atgaacatcg tcaggaagaa
    22141 gcccatcggc gtccagatgc tgtaccaggt cggaacggta tcaatgctgt tatacacacg
    22201 caccatcatc cagacaaaga cgacgccaag aaccatcgtc accaccagcc atagcgtacg
    22261 caatgccggt gacagctttt tcagcattgc cagcaaccag ccgatgccgc ctacagcaaa
    22321 aaagatcgaa ccgctggcga tttcgttact gagtgctgaa gcccctaccc ggttgagcga
    22381 gttaaaggcg cgcatcggtg aaccaagatg gagcatagag gcgataaagc caatgcccat
    22441 cagcacccat aagccaaaca tgcaggcgat aacacgctgc tgggcttctg ctcgcaggtc
    22501 gcctttgagc agcgccaaag ccagaacgat aaaaccaccc gctacacatt gcccgaagac
    22561 cgtgaagatc atcagcggcc attcatgcca tccacttccc atctcacacc tccttcgggt
    22621 ttgccaggta gccagtggta tccccggtcg ggcggctgtt ggcattgggt ttgatcacaa
    22681 tattcggttt ggtaaagtga gctcgcggca acggcgcaac ggccgccaga tcgccatgtt
    22741 ttttacgcag ctcgtcgata ggaccgaaat ccagcgcccg cagcgggcaa gattcaacac
    22801 agatcggctt tttaccctcc gcaacacggt cataacaacc atcgcatttg gtcatatggc
    22861 ctttcgtttc gttatattgc ggtgcgccat acgggcaagc catatgacag tagcggcagc
    22921 caatgcatac atcttcatcg accacaacaa aaccatcttc gcgtttatgc atcgcaccgc
    22981 tcgggcagac tttagtacaa gccggatctt cgcagtggtt acatgaaatc gacagatagt
    23041 aggcaaacac gttctggtgc cagacaccgt tatcttcctg ccagtcgccg ccagcatatt
    23101 cataaatgcg gcggaagctg acttctggcg tcaaatcttt gtagtcttta caggccagct
    23161 cgcaggtttt gcaaccggtg caacggctgg aatcaataaa aaatccatac tgggttgtca
    23221 tcggttactc cttacacctt ttcaacctga acaaggtttg tatgtgacgg attcccctta
    23281 gcgagaggag acggacgttg agtggtcagt acgttgatac aaccgccctt atcgacacgt
    23341 tttgtatccg ggtcatacca ggcaccttca cccagtgcga ccacacccgg catcattcgt
    23401 ggcgtcactt tcgcctcaat atgaacctca ccacgatcgt taaagatcct gactttatcg
    23461 ccgttgttga taccgcgttt ttgcgcatca agcgggttga tccacatttc ctgacggcaa
    23521 gctgctttca gcacatcaac gttgccgtaa gttgagtgaa cgcgagattt atagtggaaa
    23581 cccgtaagct gcagcggata ctgtttgttc agcggatcct gataactttc aaagcccggc
    23641 gtgtagatcg gcagtggatc gatcacatcg ccttctggca attcccaggt agcggcaatg
    23701 tcagccagcg cctgcgaata aatctcaatt ttgcccgatg gcgtagtcag cgggtttgcc
    23761 tgcggatctt cacggaaggc tttataagca acgtgatgcc cttgtgggtc gcgcttttta
    23821 aagatcccct gcttgcggaa ctcttcaaac gttggcagtt caggaatcgc ttcccgcgac
    23881 tgggcataca gatgccgcat ccactcttcc tgggtacggc cttcagtaaa ctgttgctca
    23941 acgccaagac gttttgccag ttcgctggtc atttcataga tggtcttaca ttcaaagcgc
    24001 ggtttaatca cctgatcgtt gaaaatcacg taagacatat tcccgcagga tgcatccagt
    24061 gcaaagtcca tctgttcgga agcggtgcag tcaggcagca ggatgtcagc atatttcgcc
    24121 gatgaggtca tgtggcagtc gataaccaca atcagctcgc acttcttatc atcctgaagg
    24181 atttcatggg tacggttgat ttcagaatgc tggttaatca ggcagttacc ggcatagttc
    24241 cagatcattt tgatcggcac atccagctta tctttcccgc gtacaccatc acgcagcgcc
    24301 gtcatttccg ggccacgttc aatggcatcg gtccacataa acatcgaaat gctggtctgg
    24361 atcgggtttt ccaaggtcgg catacggaca aacggtaagc tgtatgaacc ttcacgcgcg
    24421 ccgctgttgc ctccgttaat accaacgtta ccggtcagaa tcgccagcat cgagatagca
    24481 cgggttgcga tttcaccgtt agcgtgacgc tgcgggcccc atccctggct gataaacgcc
    24541 ggtttggtac tgccgatttc acgagccagt ttgatgattt tgtctgccgg aacaccggtg
    24601 atttgtgagg cccattccgg tgttttagcc acgccatctg gcccttcacc cagaatataa
    24661 gctttatagt ggccattttt cggcgcactg gctggcaggg ttttctcatc gtagccaacg
    24721 caatatttat cgaggaatgc ctgatccacc aggttttcag tgatcatgac gtacgccaga
    24781 ccgttaacca gtgcggcatc tgttcccgga cgaataggga tccactcatc ttcgcgcccg
    24841 gcaccggtgt cggtatagcg cggatcaatg atgatcatgc gggcattaga tttctggcgt
    24901 gcctgttcaa gatagtaagt caccccaccg ccactcattc gcgtttcgcc agggttatta
    24961 ccaaacagca ctaccagctt actgttttcg atatccgacg ggctgttacc atctgcccag
    25021 ccgccgtagg tatagttcaa accttccgca atttgcgcgg aggagtagtc gccgtaatgg
    25081 ttcagatagc cgccgcagca gttcatcagc cgcgcgacca gggtatttcc cggcggccag
    25141 gagcgggtca tggtgccgcc cagcgtaccg gtgccatagt tcagatagat agactcgttg
    25201 ccgtactctt tgatcaggcg ctgcatattg gtcgcgatga tgtcgtaggc ttcttcccag
    25261 ctaatgcgct cgaatttgcc ttcaccgcgc gccccgactc gtttcatcgg atatttcagg
    25321 cggtccggat tgtagacacg gcgacgcatg gaacgcccac gcaggcaggc gcgaacctgg
    25381 tgcaggccgt cgtaattgtc atcgccggta ttgtccgttt cgacatattt gatttcaccg
    25441 tccacgacgt gcatacgtag cgggcagcga ctaccacagt taactgtaca ggcgctccag
    25501 ataacctttt cgtctgattt tgttggaatg gcgctatcga cagcgtgcgc aatccgacta
    25561 aaaggtaatg ttaatgcgct gctggccatt gccaggccgc cgatcgctgt cgtttttacc
    25621 aaaccacggc gactcacctc agcagccaat accgcatcag ggattttcgt tttcataatg
    25681 gctcactcaa gcttgctcac gattgattcc agtaacaaac cgtattgtgt aattatttct
    25741 atagcagctc gctatatagg cttgtataca tcgaataatt tgaaaatcaa agagataggt
    25801 agattttcac tcgaaagtag tattacgtgt aagtgaggag taattattgt tcggtatcaa
    25861 agggagacaa aaaaagcgcc cgcaggcgct ttttagattc agaaaaattg ggtattagcc
    25921 aatatattcc agtccgttca tatacggacg cagaacttct ggtacttcaa tacgaccatc
    25981 agcctgctga tagttttcca ttactgcaac cagcgtacga ccaacagcca gtccagaacc
    26041 gttcagggta tgaaccagac gggttttctt gtccgacttg ctgcggcaac gagcctgcat
    26101 acgacgcgcc tggaaatccc aaacgttgga gcaggaagag atctcgcggt aggtgttctg
    26161 tgccgggatc catacttcca ggtcgtaagt tttgcaagcg ccaaagccca tgtcgccggt
    26221 acaaaggatg attttacggt acggtaggcc cagcagttgc aggacttttt ctgcatgacc
    26281 agtcatctct tcc
//
