LOCUS       NZ_CP102665            20615 bp    DNA     circular CON 07-JAN-2024
DEFINITION  Sphingobium sp. JS3065 chromosome 2, complete sequence.
ACCESSION   NZ_CP102665
VERSION     NZ_CP102665.1
KEYWORDS    RefSeq.
SOURCE      Sphingobium sp. JS3065
  ORGANISM  Sphingobium sp. JS3065
            Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
            Sphingomonadaceae; Sphingobium.
REFERENCE   1  (bases 1 to 1017992)
  AUTHORS   Li,T., Xu,J., Xu,Z.-J., Xu,Y., Spain,J.C. and Zhou,N.-Y.
  TITLE     Molecular mechanism and evolution of 1-nitronaphthalene catabolism
            in Sphingobium sp. strain JS3065
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1017992)
  AUTHORS   Li,T., Xu,J., Xu,Z.-J., Xu,Y., Spain,J.C. and Zhou,N.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-AUG-2022) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai,
            Shanghai 200240, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. v0.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio RS
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/07/2024 05:42:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,942
            CDSs (total)                      :: 4,873
            Genes (coding)                    :: 4,751
            CDSs (with protein)               :: 4,751
            Genes (RNA)                       :: 69
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 122
            CDSs (without protein)            :: 122
            Pseudo Genes (ambiguous residues) :: 0 of 122
            Pseudo Genes (frameshifted)       :: 40 of 122
            Pseudo Genes (incomplete)         :: 96 of 122
            Pseudo Genes (internal stop)      :: 12 of 122
            Pseudo Genes (multiple problems)  :: 23 of 122
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:10:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 315632
            Orig. end                         :: 336247
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102665.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20615
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hserlactone"
                     /region_number="1"
                     /rules="Autoind_synth"
                     /tool="antismash"
     cand_cluster    1..20615
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20615
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10615](+)"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10615
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
     gene            complement(122..337)
                     /locus_tag="NUH86_RS18825"
                     /old_locus_tag="NUH86_18830"
     CDS             complement(122..337)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013040122.1"
                     /locus_tag="NUH86_RS18825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18830"
                     /product="hypothetical protein"
                     /protein_id="WP_093086336.1"
                     /transl_table=11
                     /translation="MQMTNAYNHSAFLAALRNAERRAASSYFDQHVLDDGEQGYVAIDE
                     GDYSTLPETLIERIVHTVPGRLVDEI"
     gene            complement(991..1416)
                     /locus_tag="NUH86_RS18830"
                     /old_locus_tag="NUH86_18835"
     CDS             complement(991..1416)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008830519.1"
                     /locus_tag="NUH86_RS18830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18835"
                     /product="DUF2958 domain-containing protein"
                     /protein_id="WP_267252845.1"
                     /transl_table=11
                     /translation="MILLEPQHIAALQANTAARRAAQEKGEREPDPVPVVKFFNPVGAA
                     TWLVTELCEDGDAMFGLADLGFGCPELGYFSLTEITALRLPFGLRIERDIGFSGLVPLS
                     LWADAARVAGSIIQAQPLIWAIAGNLPDEPESGKAID"
     gene            complement(1413..2357)
                     /locus_tag="NUH86_RS18835"
                     /old_locus_tag="NUH86_18840"
     CDS             complement(1413..2357)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010398869.1"
                     /locus_tag="NUH86_RS18835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18840"
                     /product="zincin-like metallopeptidase domain-containing
                     protein"
                     /protein_id="WP_267252846.1"
                     /transl_table=11
                     /translation="MSYQDQPQRFGSTLYAEVTERIIAELEAGTLPWVKPWDDGKATLG
                     LPRNAGTGRRYSGINILILWSTLFERGYQSQGWLTYRQVVALGGHVRKGEQGTTVCYAD
                     KFTPKAKDGDPIRDGDEARQVAFLKRFTVFNLDQIEGVDLEPARIRTTHNAAVLIPRAQ
                     ALIDATGAEIRIGGSDAYYAPATDQICVPPPEVYYEPINWYRTVLHELTHFSGHRSRLD
                     RLPKTGFGSPDYAREELIAEMGSAFLCAELGIVPTVRHSDYLGSWLSVLREDARAIFRA
                     ASQASKAADFLLGFLPPAQSGEEAMTIEGRLAA"
     gene            complement(2761..2979)
                     /locus_tag="NUH86_RS18840"
                     /old_locus_tag="NUH86_18845"
     CDS             complement(2761..2979)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NUH86_RS18840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NUH86_18845"
                     /product="hypothetical protein"
                     /protein_id="WP_267252847.1"
                     /transl_table=11
                     /translation="MAARRPEGCMADRFRIGLATLNYLPRITYYLHVKDDFTFPEIAFR
                     LGCSVWDVEEHFAAALAHLDEAVHLGG"
     misc_feature    2937..2951
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     gene            complement(3043..4860)
                     /locus_tag="NUH86_RS18845"
                     /old_locus_tag="NUH86_18850"
     CDS             complement(3043..4860)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003039736.1"
                     /locus_tag="NUH86_RS18845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18850"
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="WP_267252848.1"
                     /transl_table=11
                     /translation="MELKHIDIANLAVSTANMRGVKKAPDLANILPSVRARGILVPLIV
                     RQNGTPETYEIVAGKRRYHAALVVAEENGGIDPLPCAVIAAGDDAAALEASLIENIARL
                     DPDEVTRWETFTRLVKEGRTPEDISNTFGLTALQVKRTLALGNLLPRIRGLYRAEKIDA
                     TTVRHLTLASKPQQKAWLALLDDEDAYVPVGHRLKEWLFGGASIPTSAAIFPLEAYKGE
                     IVADLFGEDSFFASADQFWETQNAAIEARADSYRDAGWADVITLEPGAYFHGWEHEHCP
                     KKKGGRVYISIDHRGSVSFHEGYVTTKEARKIEKGESIERPARPELSAPLTEYLNLHRH
                     AAVAAKVAETPAVALRLMVAHAICGSTLWRVERQSQKSRNEATSESVESCLSEGSTDFF
                     RREALAKLALDEDEPSLVGCDADIVPLFARLMTLPDKDVLAVLAVVMAESLQSGTMLIE
                     LLGSQLEVDMAQVWEADDAFIELLRDKALVGHLLADVAGAEVAASNAKESGKVQRGIIF
                     NCLHGQMGWEKREGWVPRWMSFPPSAYTSRGGVAPVDQWAALEAALAPAPEQPEGQATP
                     DMIEPADASAEAVSDPVSDEDEGPEQLAA"
     misc_feature    complement(5220..5235)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.96"
                     /tool="antismash"
     gene            complement(5233..5724)
                     /locus_tag="NUH86_RS18850"
                     /old_locus_tag="NUH86_18855"
     CDS             complement(5233..5724)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NUH86_RS18850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NUH86_18855"
                     /product="hypothetical protein"
                     /protein_id="WP_267252849.1"
                     /transl_table=11
                     /translation="MLTDDATGSTGAPQTRDYFAEMYVAGILADAGWDVYFPRRDKGFD
                     MIVSRPSGASTIVRPVQVKGKYSTDEKTDKARYGYVGRVTAFHNDMILAMPYFTSQSLG
                     APMLIAWMPRGEIKQHSKGWRCEPARFVGGVPEARPGFAHFFGAAGLSAFEAEVGISII
                     "
     gene            5781..6101
                     /locus_tag="NUH86_RS18855"
                     /old_locus_tag="NUH86_18860"
     CDS             5781..6101
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007682968.1"
                     /locus_tag="NUH86_RS18855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18860"
                     /product="hypothetical protein"
                     /protein_id="WP_267252850.1"
                     /transl_table=11
                     /translation="MSHAGIPMAIDQYSGYYPAMAKSPLERAARALCSFDGHAENIKFE
                     GKPMWQSYLPQARATLEAIRDPGPAALEAGGEQISTEGFKIGAQVAGWTWERMVGAILE
                     NE"
     gene            complement(6177..6971)
                     /locus_tag="NUH86_RS18860"
                     /old_locus_tag="NUH86_18865"
     CDS             complement(6177..6971)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007705667.1"
                     /locus_tag="NUH86_RS18860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18865"
                     /product="fructosamine kinase family protein"
                     /protein_id="WP_267252851.1"
                     /sec_met_domain="APH (E-value: 3.8e-15, bitscore: 52.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIRASTLLGRQVCAVSRLSGGDLSTVFRLDLGNGDTAIAKQAPS
                     VAIEARMLRHLALRAVPVPGVIAQDGDLLIMEDLPSSRGGVRSWAELAEILDSLHGRSG
                     IHYGWEEDYAFGAVAICNRPTSSWVTFWADERLRCHLPYVSFVVGERISALCDRLGDLI
                     PEKPVPSLLHGDLWSGNILFNGDQVAGLIDPACYYGDREVDCAMLGLFDNPPAAFFEAC
                     GLEAGWEQRQPVYRLWPLLVHLRLFGDAYARQVGACLGELGF"
     gene            complement(7102..7302)
                     /locus_tag="NUH86_RS18865"
                     /old_locus_tag="NUH86_18870"
     CDS             complement(7102..7302)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010214848.1"
                     /locus_tag="NUH86_RS18865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18870"
                     /product="hypothetical protein"
                     /protein_id="WP_267252852.1"
                     /transl_table=11
                     /translation="MSIIATIMNSATGQPIQKMTFGRMPKPWATFNLETGERVTADRVH
                     VGKPAPGKFAAPVEVWVTPKG"
     misc_feature    complement(7970..7983)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.66"
                     /tool="antismash"
     gene            8018..8293
                     /locus_tag="NUH86_RS18870"
                     /old_locus_tag="NUH86_18875"
     CDS             8018..8293
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017182407.1"
                     /locus_tag="NUH86_RS18870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18875"
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_267252853.1"
                     /transl_table=11
                     /translation="MSLSDLIATIAANEGLAKTDVKKVVDGLFAQIAEAAEKDEEVSVP
                     GFGKFKVKHSAARDGRNPSTGETISIAASRKLGFTPAKALKDRLNG"
     gene            8959..9717
                     /locus_tag="NUH86_RS18875"
                     /old_locus_tag="NUH86_18880"
     CDS             8959..9717
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015437.4"
                     /locus_tag="NUH86_RS18875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18880"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_267252854.1"
                     /transl_table=11
                     /translation="MYIGPQLSEFIGNCRMVEDEFALKALLCDITPSIGCEQFALVSHV
                     DLVGPPREATIIMNYHEGWVERSLLSNYYIDDPVHAASTRTVTAFLWSLIPSMISLTQR
                     QLRILDEARPFGLVEGLTVPVHSPGEYRGTCSFGGPGPIELTAQLLGAVQVIGMFSFEA
                     ARRIQCKRWGLATGDDRVPTLTPRQLDCIALVACGKTDREIGIILELSPHTVRDYVDDA
                     MRRYDVYKRTELVARCLFDGQICYRSFCRS"
     gene            10001..10615
                     /locus_tag="NUH86_RS18880"
                     /old_locus_tag="NUH86_18885"
     CDS             10001..10615
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013832888.1"
                     /locus_tag="NUH86_RS18880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18885"
                     /product="acyl-homoserine-lactone synthase"
                     /protein_id="WP_267252855.1"
                     /sec_met_domain="Autoind_synth (E-value: 6.1e-24, bitscore:
                     80.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHIIEGSREQEHAALRSMYAARKSVFVDLLGWDVPVLEGQYEID
                     QFDGPQTLYLIAAEPDGTHLGSLRLLPTSGPTLLGDIFDFLCEAGPPASKAVWEISRFC
                     LSRELRAAQRRQVRNRLVTMAARFALDNGIERYCCVADMPWFSQILSFGWECRPLGLPQ
                     MLPCGMTGAMEISIDRDTPARMAEAGVWQDTPVHFAAAAAA"
     gene            10628..11533
                     /locus_tag="NUH86_RS18885"
                     /old_locus_tag="NUH86_18890"
     CDS             10628..11533
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013832887.1"
                     /locus_tag="NUH86_RS18885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18890"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_267252856.1"
                     /sec_met_domain="PhyH (E-value: 3.6e-26, bitscore: 88.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANLPDIAPLADLHASALLDQGYCIIPAALPAASAQDLAKDLSAD
                     FESAAASTGPFYGNDTKRFGSLLNRSPHAQAFVQHDLILAVVRRILGPWCDHVALNLTQ
                     AIELMPGSIEQVPHRDQDMWPCSRLIDPDLHVEFLVNVMWPFTSFTRDNGATRVWPGSH
                     RRQEEMILDPDDAIVAEMEPGSALLFLGSTLHAGGANRTDSPRRGMIVSYALGWLKPYE
                     LQWLAYPPDVARQFDPDLSDLVGYRIHRPNLGNYEGRCPSTMLRNPDAKVGAVDALGDE
                     QHALIETYRREGLLPSVAPS"
     gene            11550..11948
                     /locus_tag="NUH86_RS18890"
                     /old_locus_tag="NUH86_18895"
     CDS             11550..11948
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NUH86_RS18890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NUH86_18895"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_267252857.1"
                     /transl_table=11
                     /translation="MDMTRNGEPIGPQESEKARRQDRARICRALMEERRLVQAAFGQKL
                     CANFNWDMLLELYEAQSEGRDVYQSALCLSAGIPDSSAHRWAAKLAARGVFARRHDDMD
                     KRRIIVTMTDDTRHALDRIMDGLARWAP"
     gene            12017..12241
                     /locus_tag="NUH86_RS18895"
                     /old_locus_tag="NUH86_18900"
     CDS             12017..12241
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NUH86_RS18895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NUH86_18900"
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_066860643.1"
                     /transl_table=11
                     /translation="MRTTLVIDDDVMEAARAIAEHQNRSIGQVVSDLARRSLRAPEAAR
                     SRNGIALLAAKPGVVVTPEIVNALRDEAP"
     gene            12238..12675
                     /locus_tag="NUH86_RS18900"
                     /old_locus_tag="NUH86_18905"
     CDS             12238..12675
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00028.1"
                     /locus_tag="NUH86_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18905"
                     /product="TA system VapC family ribonuclease toxin"
                     /protein_id="WP_267252858.1"
                     /transl_table=11
                     /translation="MTYLLDVNVLVALIDPNHVGHDAAHHWFESIGARAWATCPITENG
                     VIRIVGNVKYPSTPGSPAEVARIIGQMRQLPGHSFWADDISLLSDERVDESRLLTSAQV
                     TDTYLLALAVAHDGKLATFDRRLSPRAVSGGKAALHLIGHQ"
     gene            12675..13595
                     /locus_tag="NUH86_RS18905"
                     /old_locus_tag="NUH86_18910"
     CDS             12675..13595
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013832883.1"
                     /locus_tag="NUH86_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18910"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_267252998.1"
                     /transl_table=11
                     /translation="MRTDLDHLPAAKQRELEEVVRILFAEFREATENATGRRKSARILK
                     IILFGSYARGDWVDAPFDANQYKSDMDILVVVNQKEMTDVAAYWSVAEQRLIDAYLIEK
                     RINTPVHFVVHSLQQVNQGLAHGRVFFMEIAEQGIALYDADGRELAKPKPKTPNQALEA
                     AQEYFDEYFGEAMQCFEVAKFGIGKSFVKKAAFDLHQTTERLYQAILLTLTFYTPYDHN
                     IAFLRLQAEGRNQALFDVWPRGTRKERAMFQKLKDAYVKARYSKHYRITSEELNWLAER
                     IEILGQMTHEICTAHIANLCRNAAH"
     misc_feature    complement(13703..13716)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.86"
                     /tool="antismash"
     gene            13972..14784
                     /locus_tag="NUH86_RS18910"
                     /old_locus_tag="NUH86_18915"
     CDS             13972..14784
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NUH86_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NUH86_18915"
                     /product="DNA-binding response regulator"
                     /protein_id="WP_267252859.1"
                     /transl_table=11
                     /translation="METGDVIPLAKCFPDGKPYTRRRDVEEDLRRLVVLPREEILAALR
                     IRDRSSPQHLKSECIVHLIRETRTDNDERYFGELYKELMRRIDTALPRVAGERVDGQEN
                     VHASAARDQIAGRFREKLSEDRTSPGTWLDYYEVMFADAIAALRTTHMGRARKQAARTE
                     TIESNDDTNEPSLAVERAVGSFDIKEELLSDDPIYRSRLAAAIRNLPDKHRRVIELTIR
                     DIPIDSSDDSVMTIRKLIGVKSEKTVRNRRNEAILMIRQALSIGDDND"
     gene            14777..15364
                     /locus_tag="NUH86_RS18915"
                     /old_locus_tag="NUH86_18920"
     CDS             14777..15364
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NUH86_RS18915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NUH86_18920"
                     /product="hypothetical protein"
                     /protein_id="WP_267252860.1"
                     /transl_table=11
                     /translation="MTDSHDADEEVLLAFAVEPEKDNATLERYLKAYPHLTDQLIDLSL
                     NLRLQHATEELTGPADEAWVEASLAAFRAASGPQETQPVIDPFAGIASSELVALRQSLG
                     VPSGVIQGFSSRLVDVVSVPASFIDALSQGLRTTAEELRRFMAGPPRLAHGASHKADNA
                     PTAGQEKITFEDLLRQCRVPEERRHQLLGSRD"
     gene            15368..18778
                     /locus_tag="NUH86_RS18920"
                     /old_locus_tag="NUH86_18925"
     CDS             15368..18778
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013040333.1"
                     /locus_tag="NUH86_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18925"
                     /product="ATP-dependent helicase"
                     /protein_id="WP_267252861.1"
                     /transl_table=11
                     /translation="MSAVELTRQRAAALHDKIISEGTDPWDPVAIVIAAASNLGLDIEP
                     VEPGSAVLEGGRAQFDPVNRAIRHEEAGSTFYRAFLVGHELGHATLGDDRVEHIAHDVD
                     PTRAAEAAPVGEDRVIDYSRRQRREIQMDLFGRELLLPRGWVRSLHLEGMTATQIAERI
                     GAPFDVVALQLLDALLLPQIEPEPEEGEVKPPKPLNEEQSKAAIHRGPPYLLEAGPGTG
                     KTQTLVGRVADLVDEGVDPRKILVLTFSNKAAGELTERIAGLRPEAASAMWIGTFHAFG
                     LDLVRRYHSRLGFPKEPRMMDRSEAIAIMEREYLALDLKHYREFMNPDRPLKDMFTAIS
                     RAKDEVADADRYAALAKDMLEKATDSAAREAAERCAEVALVYRKYEELKRGACAVDFGD
                     LVSLPVKLLDSAADVVSMLRGTYSHVLVDEYQDVNRSSVRLLQRLTDGGDNLWAVGDAR
                     QAIYRFRGASSFNMSRFRSNDFSGGTGSRLRLNYRSTPEIVGAFSRFGATMQAGTSDAS
                     LDAYRPSSGIAPEHVTFGDNDDEAAALADEILRCSEDVAFREQAVLCSGNDRLNRMGRE
                     LERRGIPVLYLGNLFERPEVKDLLSILSLLVDRRAMGLVRKPSLPDLATGITLTGAAAV
                     VDHLRLTEADPLAWAGASPSLQVLDAADMAAVSKASAMVTGFDSQSNPWTVLAHVLLDR
                     TRTAASLASTADVASRSMGVAIWQLMGFLRAERPAPEPGLPVQRTLDGIRRLIQLADER
                     DLRQLPQAAQGIDAVRLMTIHGSKGLEFPVVHVMGLNKNSMPNTWRKPACPVPDGMIEG
                     GKGGTMEISAADHALEQECLFYVATSRARDRLLLYSARHTTTNARRDPSPFIGRLGVSV
                     ARAAMATATSSPDPEDLPLPITMGSAIKITIAQLSLYDRCPRRFLYTHVLGVGGRRTPT
                     TMTRMHDLVRAVVTEIASTQPSSTSLDEMERLLDERWSEGSLAGDEYRLHRDVAATLLR
                     RFVRMRAGTTRTGAAGLRAGIGTNTITADADDVVTTASGAHCVRMVRTGHSSSTTGKSL
                     ADAAFQMAASASLPGCAAEIIHLGDDDPSTSVSFSPKLLGTKEEKLTELFKSIGGGHFA
                     PERSGRTCPFCPAFFTCGPVAEGNLQKNL"
     gene            18866..19609
                     /locus_tag="NUH86_RS18925"
                     /old_locus_tag="NUH86_18930"
     CDS             18866..19609
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025808.4"
                     /locus_tag="NUH86_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18930"
                     /product="multiubiquitin domain-containing protein"
                     /protein_id="WP_267252862.1"
                     /transl_table=11
                     /translation="MSILENHDIDDVELAVQQDRPLRPGRYRVHLAVDSIGFTPLVLDD
                     PVPLGRQILKKAGIIDLDGHSLFLIRPEGDFEDVRADEEVDLRDRGAYRFIAFSTDPLY
                     RVKLNEARIVWGRSSIPEAVLRALAGIGDDEAVFLEVRGGKDKLIKPGTEADLSAGGVE
                     KFITAPNKVTYTFFVNGKPYETEKKKLTGAQIKEMVPDWDPQHDLSLEGEGDEPDRTIA
                     DDEAVSLDPKHGVRRFSSVPKANFG"
     gene            19609..19992
                     /locus_tag="NUH86_RS18930"
                     /old_locus_tag="NUH86_18935"
     CDS             19609..19992
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025817.4"
                     /locus_tag="NUH86_RS18930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NUH86_18935"
                     /product="E2/UBC family protein"
                     /protein_id="WP_267252863.1"
                     /transl_table=11
                     /translation="MSGILDMQLEQLRERFGDVQTRRLPSGTTLVIVPGVRLPEGWSKV
                     SATIRFIVPPGYPFAQLDCFWADPDLRLAHGGVPQNSATSPIPETVEPALWFSWHLTGP
                     WNANRDTLSTWMNVVIERMRQIR"
ORIGIN
        1 cgcaggcttc gagccggaag gcgcgggcct cttggaagaa tggccatggg ggctcaatgt
       61 ccccatggcc ctgcccctga acaagcgaaa agccggaggg gcgcgcgacc cctcctgacc
      121 ttcagatttc gtcgaccagc cttcccggta cggtgtggac gatccgctcg atgagcgtct
      181 cgggaagcgt cgaataatcc ccctcgtcga tggcgacata gccctgctcg ccgtcatcca
      241 ggacatgctg gtcgaagtaa ctcgaagcgg cgcggcgttc agcgttgcgg agtgcggcga
      301 gaaaagcgct atgattgtaa gcattcgtca tctgcatggg agcctccttc atctggaaaa
      361 gacgggaggt ccggcggcgg gccgacaagc ccgggtcaag gagcgccggt gcagccggcg
      421 accgcgcagc gggcggtgga ggaaccgatt tagttgccgc cgctgccgcg cgaagcgtgg
      481 cggaggcggc ggctaaattg gaggggccac ggatccttga ggcgggtgaa ggcagcctgc
      541 caagatggga cttttgtgaa gtatctatgt gtggcctccc cccccgccga ggcgtagcgc
      601 cgtgcggacc ggccggtccg catgacacgc gagcgaggcg gaaaggctcc cccctcaggg
      661 atgccaccca caaagacagc aacagtcgtc aatgctggtc agcgtgcaga cgcccggctc
      721 ctagtccggc tcttcctcgc catcgccgta accgaactcg gcggcgatcc gcagcgcctt
      781 atcccgcagc aaagtgcaag agcgtgaacc gcaaccgttc agggggtcaa ctttggacgc
      841 ccatcacccc aaaactgggg tcaacattgc aggcttattc acagatagca ttttgccgtc
      901 cgtgtgcacc gtgctgatgg aattgtcggt catgtcatcc cctatgttgg cggcgggatt
      961 gcccggtgcg atcccgcctc cgtgccgtgt tcagtctatg gccttgccgc tttcgggttc
     1021 gtcggggagg ttcccggcga tggcccagat gaggggttgg gcctggatga tggaacctgc
     1081 gacccgcgcc gcgtccgccc aaagggacag cggaacaagt ccgctaaagc cgatgtcccg
     1141 ctcgatccga agcccaaagg gaaggcgaag ggccgtgatc tccgtgaggc tgaaatagcc
     1201 cagttcagga cacccaaagc caaggtcagc gagcccaaac atggcgtcgc catcctcgca
     1261 aagctcggtc acaagccatg tcgccgcgcc cacgggattg aagaatttga ccactggcac
     1321 cgggtccggc tccctttcgc ccttctcctg cgcggcacgg cgcgctgcgg tgttcgcctg
     1381 aagggctgcg atatgctggg gttcaaggag gatcatgcgg ccagcctccc ttcgatggtc
     1441 atcgcttcct cgcccgattg cgccgggggc aggaagccca gaagaaagtc ggcggccttg
     1501 ctcgcctgac tggcggcgcg gaaaatggcg cgggcatcct cgcgaaggac ggaaagccac
     1561 gatcccagat agtcgctatg gcggacggtc ggcacgatcc ccaattcggc gcaaaggaag
     1621 gcgctcccca tttccgcgat cagttcctcg cgggcataat cggggctgcc gaatccggtc
     1681 ttgggcaggc ggtcgaggcg cgagcgatga ccagaaaaat gggtcagttc atggaggacc
     1741 gtccgatacc agttgatggg ttcataatag acttcgggcg gaggaacgca gatttgatcg
     1801 gtggccgggg cataataggc gtcgctcccg ccgatgcgga tttccgcacc ggtcgcatcg
     1861 atcaatgctt gcgcgcgggg gatcaggacc gccgcattat gcgtggttct gatccgggcg
     1921 ggttccaaat ccaccccctc gatctggtcc agattgaaga ccgtgaagcg cttcaggaat
     1981 gcgacctgcc gggcctcgtc gccgtcccgt atcgggtcgc cgtccttggc cttgggcgtg
     2041 aatttgtcgg catagcagac ggtcgtgccc tgctcgccct tgcggacatg ccccccaagc
     2101 gcgaccacct gccgataggt aagccagccc tgcgactgat agccccgctc gaaaagggtg
     2161 ctccagagaa tgagtatgtt tatgcctgaa tagcgccgtc cggttccggc gttgcgcggc
     2221 aggccaagcg ttgccttgcc atcatcccaa ggcttgaccc atggcagggt tcccgcttcc
     2281 agttcggcaa tgatgcgctc cgtcacttcg gcgtagaggg tggaaccaaa gcgctgcggc
     2341 tgatcctgat aactcatcgt tcttactcct gtcgcatcgc accggccgcc ggaacggcgg
     2401 gggtgggcgg caggagcgaa ccgacaggcc cgccggccga ggcgggcggc acccgcaggg
     2461 ccgcaacgca gtgaaggagt tggggcttaa gccccgaact tgcggctcgc cgcggtgggc
     2521 ctatagggca gcgacgccca cccccgcctc cccggaggcc gagcaaacca accggcaaac
     2581 atcgccgcgc cctggcgcgg tggccgcccg accttttcgc gctgccaccc gcagcgctcc
     2641 gcattccctg atcaaggcat tggatggacg aagcggcgca tcagggaaaa accgtcgcgg
     2701 gatgcacctg ctcaaacact gccgggcggc cgagccgccc ggcgcgattt cctccctgca
     2761 tcagcccccg agatgcacgg cttcgtcgag atgggcgagc gcggcagcga aatgttcctc
     2821 gacgtcccag accgagcagc caagacggaa ggcgatttcg gggaaggtaa agtcgtcctt
     2881 cacgtggaga taataggtga tgcgggggag atagttgagg gtagcgagac cgatgcggaa
     2941 gcggtcggcc atgcagcctt cgggcctgcg ggcagccatg agacggttcc tttcatgcaa
     3001 aaaggcaggc ggcggaacgg accgccacct gccctgtggt gatcaggcgg ccagttgctc
     3061 cggcccttcg tcctcgtccg acacgggatc gctcacggct tcagccgacg cgtcggcggg
     3121 ttcgatcata tcgggcgttg cctgcccttc gggctgttcg ggtgccgggg ccagagccgc
     3181 ttccagcgcc gcccattgat cgaccggcgc gaccccgccc cggctggtat aagcgctcgg
     3241 cgggaagctc atccagcggg gcacccagcc ctcgcgcttc tcccatccca tctggccatg
     3301 gaggcaattg aagatgatcc cgcgctggac cttgccgctt tccttggcgt tcgacgccgc
     3361 cacttcggcc ccggccacat cggcaagaag atgaccgaca agcgccttgt cgcgcagcaa
     3421 ttcgataaag gcatcgtcgg cctcccagac ctgcgccata tcgacctcca gctgactgcc
     3481 cagcagttcg atcagcatgg ttcccgactg gagcgactcg gccatcacca ccgcaagcac
     3541 ggcaagaacg tccttgtcgg gaagcgtcat gagccttgcg aagagaggca cgatgtccgc
     3601 atcgcagccg acaagactgg gttcgtcctc gtccagcgcc agcttcgcca gcgcctcgcg
     3661 ccggaagaaa tcggtcgaac cttccgagag gcagctttcg acgctttcgc tggtcgcctc
     3721 gttccggctc ttttgcgact ggcgctcgac ccgccacaaa gtggaaccac agatcgcatg
     3781 ggcgaccatc aaccgcagcg cgacggcagg agtttccgcg accttcgccg ccaccgccgc
     3841 atgacgatgg aggttcagat attcggtgag cggggcgctg agttccggac gcgccggacg
     3901 ctcgatgctc tcccccttct cgatcttgcg cgcttccttg gtggtgacat agccttcatg
     3961 gaagctgacg ctgccgcgat ggtcgatgct gatatagacc cgtcctccct tcttcttggg
     4021 gcaatgctca tgttcccagc cgtggaaata ggctcccggc tcaagggtga tgacatcggc
     4081 ccagccagcg tcccgatagc tgtccgctct ggcctcgatc gcggcgttct gcgtttccca
     4141 gaactggtcg gcgctggcga agaaactatc ctccccgaac aggtccgcta cgatctcgcc
     4201 cttataggct tcgagcggga agatcgccgc gctggtcgga atgctggccc cgccgaacag
     4261 ccattccttg agacggtggc cgacagggac ataggcgtcc tcatcatcga gcagggcgag
     4321 ccatgccttc tgctgcggct tcgaggcaag ggtcagatgc cgcaccgtgg tcgcgtcgat
     4381 cttctcggcg cgataaagcc cccggatgcg cggcagaagg ttgccgagcg cgagggtccg
     4441 tttcacctgc aaggccgtaa gcccaaaggt gttggaaata tcctccggcg tccgcccttc
     4501 cttgacgagg cgggtgaagg tttcccagcg agtcacctca tcggggtcca acctcgcgat
     4561 attctcgatg agcgaggctt cgagcgcggc ggcgtcgtcc ccggccgcga tgacggcgca
     4621 gggaagcgga tcgatcccgc cattttcctc agcgacgaca agggcggcat gatagcgccg
     4681 cttgcccgcg acgatctcat aggtttcagg ggtgccgttc tgccgcacga tcagcggcac
     4741 gagaatcccc ctcgcccgga cggagggcag gatattggcg aggtcgggcg ccttcttcac
     4801 gccccgcata ttggcggtcg agacggcaag attggcgatg tcgatatgct tgagttccat
     4861 gacgtggttc cttctcttga ctaacaccac cggcccggcc gaagcggggt gggcggcaag
     4921 agcgaaccgg caaggcccgg cgacagaggc gggcggcatc tgtcaggacc gaaacgaagt
     4981 ggaggagccg cgccgaaggc cggcttgtag cccgccgcga cgggcctaga gggcagcgac
     5041 gcccacagcg ctttggactg gccggctcaa accggcacca tcgcgcatag cgcgatgacc
     5101 gcagtgcgtc agggatcgca gcccgaaggg gcgagacggc gcagacggct cgatggagcc
     5161 gtacgcggag cagagcccgg tccccgacgg ggagacgctc attccccttg aactcgtcaa
     5221 cgaccaagcg gtctaaataa tggaaatccc gacctccgcc tcgaacgcgc tcagtcccgc
     5281 cgccccgaaa aaatgagcga aaccgggccg tgcctcggga acgccaccca caaacctggc
     5341 aggttcgcac cgccagccct tgctgtgctg cttgatctct ccgcgcggca tccacgcgat
     5401 cagcatcggg gcaccgaggc tttgcgaggt gaaatagggc atggccagga tcatgtcatt
     5461 gtggaaggcg gtgacgcgcc cgacatagcc gtatctcgcc ttgtcggtct tctcgtcggt
     5521 tgaatatttg cccttcacct gaaccgggcg gactatcgtc gatgcgccgg acggacggct
     5581 gacgatcatg tcgaacccct tgtcgcggcg ggggaaatag acgtcccaac cggcatcggc
     5641 gagtatgccg gcaacataca tctcggcgaa atagtcgcgg gtttgcggcg ccccggtcga
     5701 tccagttgcg tcgtccgtca gcataaccgc tgtattcctg tatccccgat caaaacagcc
     5761 tcccctcaag atcggccaat atgtcgcacg ccggtatccc gatggccatc gaccaatatt
     5821 ccggctatta tccagccatg gcaaaatctc ccctggagcg cgccgcccgc gccctttgca
     5881 gcttcgatgg ccatgccgag aacatcaagt tcgaaggcaa gcccatgtgg caaagctatc
     5941 tgccgcaggc gcgtgcgacg cttgaagcca tcagggatcc tggccctgcc gcgttggagg
     6001 ccggcggcga acagatttcg accgaaggct tcaaaattgg tgcgcaggtc gcgggctgga
     6061 cctgggaacg catggtcggg gcgatcctcg agaatgaata acatccgcgg ctgacgtgag
     6121 atcgggccgt gaccgatggc gaaacgcttt catccatatc cgccagaaag acgggttcag
     6181 aaccccagtt cgccaagaca ggcccccacc tgccgagcat aggcgtcccc gaacaggcga
     6241 agatggacca gaagcggcca gagccgatag acaggctggc gctgctccca gcctgcttcc
     6301 aggccacagg cctcgaaaaa ggcggccggc ggattatcga acaggccgag catggcacaa
     6361 tcaacctccc gatcgccata atagcaggca gggtcgatca gccccgcaac ctggtcgccg
     6421 ttgaagagga tattccccga ccacagatcg ccatggagga gcgagggcac cggcttctcg
     6481 ggaataagat cgcccagtcg atcgcaaagt gcggaaatcc gttcgcctac gacgaaactg
     6541 acatagggca gatggcagcg cagccgctca tcggcccaga aggtcaccca gctcgacgtc
     6601 gggcgattgc agatcgcgac ggcaccgaag gcatagtcct cctcccatcc ataatgaatg
     6661 ccgcttcggc cgtgcagact gtccagtatc tcggcaagct ccgcccagga tcggacgccg
     6721 ccacgcgaag agggaagatc ctccatgatg aggagatcgc catcctgtgc gatcacgcca
     6781 ggcactggca cagcgcgaag cgccaggtgc cgcaacatgc gcgcctcgat cgcaacactt
     6841 ggcgcctgtt tcgcgatggc cgtgtcgcca ttgccgagat cgagccggaa gacggtcgaa
     6901 aggtcgccac cggaaaggcg actgaccgcg cacacctggc ggcccagaag ggtagaggcg
     6961 cgtatcagca tgacagggac aaagctcgcc tcagcccgtc acacctcctt ccagaagtag
     7021 cggcgcccgc aatcatggat ccctgcctcc cgctcatgtc aggatcgcgc gctgccatcg
     7081 tctttcccct tctatgcgct ctcatccctt gggcgtcacc cagacctcga caggcgcggc
     7141 gaacttgccg ggagcgggct tgccgacatg gacccgatcc gcggtcaccc gctcgcccgt
     7201 ctcgagattg aaggtcgccc agggcttggg catgcgtccg aaagtcatct tctggatggg
     7261 ctggccggtc gccgagttca tgatggttgc tatgatgctc atgtcgcccc gatagcggcg
     7321 tgacggcatg ggtgtaagcc cttcatatat gccgatctgc cgtggcggtc atcacgcact
     7381 tcctgcgagg cccagttctg aattccacag cgcgccggtg ggaacgtccc ttcatcgagc
     7441 cggcgacgcc aggatcagga aagccatgtt tgccccccaa gttgtcaaag cgccttaccc
     7501 cgaccttgca tcggcatgaa atcgtgccac attcgacact ggcgggccga cccataagga
     7561 aaaatggatc atgcccaaac agaatgaacg tgagcgcctg gccgacctcg aggcgcgcca
     7621 gcgcaggagg agattgcggc ggcgcgcagc gcgcttcgcg caagatatgg tgcgatcgtt
     7681 gccgagcttc ctatggaggc gatcggcgag cgggattttc gggacatcct ccagcacgca
     7741 atccgcgccg gcggcactgc cgcccttcag gcgctcaaag cgttgccgcc cgctccggag
     7801 ccaatgtctc ccgcttctaa atccgcggtc gcatcccaag gtcagaaacc ggcccccgcc
     7861 cggatcgtcc cgccgctatc ggctcagtct catttgccgt ctgaagagcg ctgaacaatg
     7921 gcttcgggca ggaaagtcgc cgagtcgccc cctcgacggc cggtcaccgt tttggcaaca
     7981 aaaagggcca cgactcgcat aacaggaacc agtatccatg tcgctttccg acctcatcgc
     8041 cacgatcgca gccaatgaag gtctcgccaa gaccgacgtc aagaaggtcg tcgacgggct
     8101 tttcgcgcag attgccgagg cggccgaaaa ggatgaggag gtttccgtac ccggcttcgg
     8161 caagttcaag gtgaagcaca gcgccgcgcg cgacggtcgc aacccctcca cgggcgagac
     8221 gatcagcatc gcggcctcca ggaagctggg cttcacccct gccaaggccc tcaaggaccg
     8281 gctgaacggc tgaaccggac gggctcggcc gacagaggcc gcgcttcgat cagcactcct
     8341 gaagcagcgc cgggccgatc agatcgatcg tccggcgcct tctctatggt gcgacatcgt
     8401 cccgcacact cgcctccagg acgcggcaac gagtggcggt ctcgatcgcg ctttgcctcc
     8461 aacctcggtt ccagcctcct ggcaatgctg ccagtcgtca gcctcgcccg cttaacgggt
     8521 acgcccccgt caggacagcg atgccttgat gtggtcgcga tggggtattc gcccagttca
     8581 cggcatgttt tcgaatggtc gacactccaa aaagtcgaag tgaatgaggg tcaatgtgga
     8641 tgaaagcttc ccgtcccgga aacggtccat gaaaaatcgt tgcgatgctg caacggctat
     8701 tcatgaaaat gtcacgaaat cccgtttcgg acgaaaaccc actatcatcg ctggtgaggt
     8761 acgatactct caaattgtcc cgtagagcga aagattccag ccggttgcgc aagcaggctg
     8821 agggcaagag ccgggcggtg agcgggacat gcgaccggaa atgcccgggc gcgtgcaacg
     8881 cagatggcgc gtcttgcgcg ccgccctgcc tggagagaag actgcccaaa ggcgctgccc
     8941 ctagtgagga gaacgcccat gtatatcggt ccacagctca gcgaattcat tggcaattgc
     9001 cggatggtgg aagacgaatt tgccttgaag gccctgcttt gcgacatcac gccatcgatc
     9061 ggctgcgagc agttcgcgct cgtcagccat gtcgatctgg tcgggccgcc ccgcgaagcg
     9121 accatcatca tgaactatca tgagggttgg gtcgaacgct cgctgctcag caactattat
     9181 attgacgatc cggtccacgc ggccagcacg cggacggtca ccgccttcct ctggagcctc
     9241 attccctcga tgatcagcct cacccaacgt cagctgcgca tcctcgatga ggcccgcccc
     9301 ttcggcctcg tcgagggcct caccgttccc gtgcattcgc ccggcgaata tcgcggcacc
     9361 tgctcctttg gaggacccgg gccgatcgag cttaccgccc aactgctggg cgcggtgcag
     9421 gtcatcggca tgttctcctt cgaggccgcg cggcggatcc agtgcaagcg ctggggcctt
     9481 gcgaccggcg acgatcgcgt gccgacgctc actcccagac agcttgactg catcgcgctc
     9541 gtcgcctgcg gcaagacgga cagggagatc ggcatcatcc tcgaactctc cccccacacg
     9601 gtacgggatt atgtggacga tgcgatgcgg cgctacgatg tctacaagcg caccgagctt
     9661 gtagcgcgat gccttttcga cgggcagatc tgctacagat ccttttgccg ctcctaggct
     9721 gacgcggaga agcccgggcg ttgggtaacg tccttgccgc tgccgcccct tggatggccc
     9781 cttgcaacgg cagacatgag gtctgaccga atgcgcacac gcgcgcccgg agcgccgccg
     9841 tcgcctgtca cgccataacg gcgtccaatg acccacatcc gtggggcgat gatgcccctg
     9901 gtcatcgctg cccgccatcc ccctttttcg cgggatggct cccctccccc atctgcgcga
     9961 acctcgatcc gcaacaggca acagcagata gggagccaga atgacccaca tcattgaggg
    10021 cagtcgcgag caggaacatg cagcgctgcg atcgatgtac gcggcgcgca agagcgtctt
    10081 cgtcgatctt ctgggctggg atgtcccggt cctcgagggc caatatgaga tcgaccagtt
    10141 tgacgggccg cagaccctct atctgatcgc ggccgagccg gacggcacgc atctgggctc
    10201 cctgcggctg ctgcccacca gcggcccgac gctgctcggt gacattttcg atttcctgtg
    10261 cgaggcaggt cccccggcca gcaaggcagt ctgggaaatc tcgcgcttct gcctgtcgcg
    10321 cgaactcagg gccgcgcagc ggcggcaggt ccgcaaccgg ctggtgacga tggcggcgcg
    10381 cttcgcgctc gacaatggca tcgagcgcta ttgctgcgtc gccgacatgc cctggttcag
    10441 ccagatcctg tccttcggct gggaatgccg cccgctcggt ctcccgcaga tgcttccctg
    10501 cggcatgacg ggcgccatgg agatcagcat cgacagggac acccctgcgc gcatggccga
    10561 agcgggcgtc tggcaggaca cacccgttca tttcgcggct gctgcggcgg cctgaggaga
    10621 agcgaccatg gcaaatttac ccgacattgc cccgctcgcc gatcttcacg cgagcgccct
    10681 gctcgaccag ggctattgca tcattcctgc cgccctcccc gccgcctcgg cccaagacct
    10741 tgccaaggat ctctccgcgg atttcgagag cgctgcggcc tctaccggtc ccttctacgg
    10801 caatgatacc aagagattcg gcagcctgct caatcgctcc ccgcatgccc aggccttcgt
    10861 ccagcatgac ctcatactgg cggtggtccg caggatcctt ggcccctggt gcgaccatgt
    10921 cgcgctcaac ctcacgcagg cgatcgaact catgcccggc tcgatcgagc aggtgccgca
    10981 ccgcgaccag gacatgtggc cgtgcagccg cctcattgat cccgacctcc atgtcgaatt
    11041 cctggtcaat gtgatgtggc ccttcacatc ctttaccagg gacaatggcg ccacgcgggt
    11101 ctggccgggc agccaccggc ggcaggagga gatgatcctc gatccagacg acgcgattgt
    11161 cgccgagatg gagccgggtt cggcccttct gtttctcgga tcgacgcttc acgcgggcgg
    11221 cgccaacagg accgatagcc cccgtcgcgg catgatcgtc agctatgcac tgggttggct
    11281 caagccctat gagctgcaat ggctggctta tccacctgac gtggcgaggc aattcgaccc
    11341 ggacctttcg gacctcgtcg gctatcgcat ccatcgtccg aacctcggca attatgaggg
    11401 ccgttgtccc tcgacgatgc tgcgcaaccc cgatgccaag gtgggcgccg tcgacgcgct
    11461 gggcgacgag cagcatgcgc tgatcgagac ctatcgccgc gaaggactgt tgccctccgt
    11521 cgccccgtcc tgacgaaagg cgaacaagca tggacatgac aaggaacggc gagcccatcg
    11581 gtccgcagga atcggaaaag gcccgccgcc aggatcgcgc gcggatctgc cgggccctca
    11641 tggaggaacg gcggctggtg caggcggcct ttgggcagaa attatgcgcc aatttcaatt
    11701 gggacatgct gcttgaactt tatgaagcgc agagcgaagg acgggacgtc tatcagtcgg
    11761 cgctctgcct ctcggccggc ataccggatt ccagcgcgca ccgttgggca gcaaagcttg
    11821 ccgcccgagg ggtgttcgcg cgacgacatg acgatatgga caagcggcgg attatcgtca
    11881 ccatgacgga cgacacccgg cacgctttgg accgcatcat ggacggcctt gcgcgatggg
    11941 ccccgtgagc cgggagttgc gtcgccgccg cgcatctatt atgatgcgtg atgacagatg
    12001 cgacaggaac gagccgatgc gtacgacact ggtcatagat gatgatgtga tggaagccgc
    12061 gcgcgccatc gcggagcatc agaaccgttc gatcggccag gtcgtttccg atctggcccg
    12121 gcgctcgctg cgcgcccccg aagccgcacg cagccgcaac ggcatcgccc tcctcgccgc
    12181 gaaacccggc gtcgtggtga cgccagagat cgtaaatgcg ctgcgagacg aggcgccgtg
    12241 acctatcttc tcgacgtcaa tgtgctcgtt gctctgatcg atcccaatca tgtcggccat
    12301 gatgccgcgc atcactggtt cgagtccatc ggcgccaggg cctgggcgac gtgccccatc
    12361 accgaaaatg gggtcatccg catcgtgggg aacgtcaaat atccctcgac ccccggttcg
    12421 ccagccgagg tggcgcgcat catcgggcag atgcggcagt tgccagggca cagcttctgg
    12481 gctgacgata tcagcctgct gtccgacgag cgggtcgacg agagccggct tctcacctct
    12541 gcgcaggtta ccgacaccta tctcctcgcg cttgccgtgg cgcatgatgg caagcttgcc
    12601 accttcgacc ggcggctctc gcccagggcc gtcagcggcg gcaaggcagc cctccacctc
    12661 atcggacatc aatgatgcgc acggacctcg accatcttcc cgcggccaag cagcgcgagc
    12721 ttgaggaggt cgttcgcatt ctgttcgcgg aatttcgcga ggcgaccgaa aatgcgacgg
    12781 gccgacggaa atcggcgcgc atcctcaaga tcatcctgtt cggttcctat gcgcgaggcg
    12841 actgggtcga tgcgccgttc gacgccaacc agtataagtc cgacatggat atactggtgg
    12901 tcgtcaacca gaaggaaatg accgacgtcg ccgcctactg gtcggtggcg gagcaaaggc
    12961 tgatcgacgc ctatctcatc gagaagcgga tcaatacgcc ggtgcatttc gtcgtccatt
    13021 cgctccagca ggtgaaccag ggccttgccc atggccgggt cttcttcatg gagatcgccg
    13081 aacagggcat cgcactctat gatgctgacg gccgcgaact cgccaagccc aagcccaaga
    13141 cgccaaacca ggcgctggag gccgcccagg aatattttga cgaatatttc ggcgaagcga
    13201 tgcagtgttt cgaggtcgcg aaattcggaa ttggaaagtc gtttgtaaag aaggcagcgt
    13261 tcgatcttca ccaaacaact gaacgattat atcaagcaat tctgctcacg ttgacgttct
    13321 atacgccgta cgatcacaat atcgcgttcc tgcggcttca ggcagaaggc cgcaatcagg
    13381 cgctgttcga cgtctggccg cgcggtaccc gaaaggaacg ggcgatgttc cagaagctca
    13441 aggacgccta tgtgaaggcg cgctattcaa agcactaccg gatcacctct gaggaattga
    13501 actggctcgc cgagcggatc gagattttgg ggcagatgac gcatgagatc tgcaccgccc
    13561 atatcgcgaa tctgtgcagg aatgctgccc attgaggcga tggaatttag ggccactaca
    13621 tcgtgatttg tgcgttggca ttggctctga cacctttacc aacgtcaaac ccagaggccc
    13681 tacaacggca aggacgggga ctttcgagac tgtccacttt ggagaacgga attggaaaag
    13741 ccgacgctaa tcgccgctac tgggagtgac gggtagaagc tgaatgggcg taatttccgt
    13801 ccataactct cgcccgggaa atcccctgct tggatggttt tcttgttcca cctatatcct
    13861 gctgatggcg ggggcgccgt gatcggggaa cgaccggaca ctccatcgcc gcgagatttc
    13921 gagatactgc cgcagtcacg gtgatggcgg gcgtcggcaa gggggtgccg tttggagact
    13981 ggagacgtaa taccgcttgc caagtgcttt ccggacggaa agccatacac gcgccgcagg
    14041 gacgtcgagg aggatctgag gaggctcgtc gtcttgccgc gcgaggaaat ccttgccgcg
    14101 ctcaggatcc gcgacaggtc gtcaccgcaa catctgaagt ccgaatgcat cgtccatctg
    14161 atacgcgaga cgcgcacgga caatgacgag cgctacttcg gtgaactcta caaggagctc
    14221 atgcgccgga tcgataccgc cttgccgcgc gtcgccggag agcgggtcga cgggcaggag
    14281 aatgtccacg cctcagcagc gcgggaccag atcgccggca ggttccggga gaagctgtcc
    14341 gaggaccgaa cctcacctgg aacctggctg gactactacg aggtgatgtt cgccgacgct
    14401 atcgcagctt tgcgcacaac ccacatgggg cgggcgcgaa agcaggccgc gcgcaccgag
    14461 acgatagaat ccaacgatga tacgaatgag ccctcgctcg cggtggaacg cgccgttgga
    14521 agcttcgaca ttaaggagga actgctctcc gacgatccga tttaccggtc gcgcctcgct
    14581 gctgcgataa gaaacctacc agacaagcac cgcagagtca tcgagctgac cataagggat
    14641 ataccaatcg attcgtccga cgatagcgtc atgacgatcc ggaagctgat cggcgtcaaa
    14701 tccgagaaga ccgtccggaa caggcgaaac gaggcaatcc tgatgatacg ccaggctctg
    14761 tcgattggag acgacaatga ctgacagcca cgacgccgac gaggaggttc tcctcgcatt
    14821 tgcggtcgaa cccgaaaagg acaacgcgac cctggagcgc tatctcaagg cgtatccgca
    14881 cctgaccgac cagctgatcg atctatccct gaacctgcgg ctgcagcacg ccacggagga
    14941 attgacgggg ccagccgacg aggcgtgggt cgaggcttcc cttgcggcct ttcgagctgc
    15001 ttccggacct caggaaacac agccggtcat cgatccgttc gcgggaatcg cttcttcaga
    15061 gctggtggcg ctccgccagt cgctcggcgt gccgagcggg gtcatacagg gtttcagttc
    15121 caggctcgtc gacgtcgtca gcgtgcccgc atcgttcatc gacgcactct cgcagggtct
    15181 gcgcaccact gcggaggaac tgcgccgctt catggccggg ccaccgcgtc tcgcgcacgg
    15241 ggccagccac aaggccgaca atgcgccaac cgccggacag gagaagatca cattcgagga
    15301 tctcctcagg cagtgccgag tgccggaaga gcggaggcat caactgctgg gctctcggga
    15361 ttgaccgatg agcgctgtcg aactcacgcg gcagcgtgcc gctgcgctgc atgataagat
    15421 aatctcggag ggaaccgacc cctgggatcc cgtggccata gtcattgcgg ccgcgtccaa
    15481 cctggggctc gacatcgaac ctgtcgagcc gggcagtgca gtcctcgaag gtggacgagc
    15541 acagttcgac ccggtcaaca gggctatccg gcacgaggag gcaggatcga ccttttacag
    15601 ggccttcctc gtgggccacg aactcggtca cgccacgctc ggtgatgacc gcgtcgagca
    15661 catcgcgcac gacgtcgatc ctacacgggc agcggaagcc gcccccgtcg gcgaggatcg
    15721 cgtcatcgat tacagccgac gtcagcggcg cgagatccag atggacctct tcggtcgcga
    15781 actcctgctt ccacgcggat gggtgcggtc actccatctt gaaggcatga cggccacaca
    15841 gatagcggaa cggatcggcg caccattcga cgtcgtcgcg cttcagcttc tcgacgccct
    15901 gctgctgcct cagatcgaac cggaaccaga ggaaggcgag gtcaagccgc caaagccatt
    15961 gaacgaagag cagagcaagg ctgcgattca ccgcggccca ccctatcttc tggaggccgg
    16021 tccggggacg ggcaagaccc agacgctcgt tgggcgcgta gccgacctcg tcgacgaagg
    16081 cgtcgacccg cgcaagatcc tcgtcctgac cttctcgaac aaggccgccg gggaactgac
    16141 cgagcgtatc gccggtctcc gtccagaggc ggcgtcggcg atgtggatcg gcacgttcca
    16201 cgcgttcggc ctcgacctgg tccgccgata tcacagtcgg ctggggttcc cgaaggaacc
    16261 ccgcatgatg gatcgcagcg aggcgattgc catcatggag cgcgaatatc ttgcgctcga
    16321 tctcaagcac tatcgcgaat tcatgaatcc cgaccgtccg ctcaaggaca tgttcacggc
    16381 gatctcgcgc gccaaggacg aggtggccga cgccgaccgc tacgccgccc ttgccaagga
    16441 catgctggag aaggcgaccg attcggctgc gcgagaggcg gcggagcgct gcgcggaagt
    16501 ggcgctcgtc taccggaaat acgaggagct gaagcgcggg gcatgcgcgg tagacttcgg
    16561 cgatctggta tccctgcccg tgaagcttct ggactccgcg gccgacgtcg tctccatgct
    16621 gcgcgggaca tacagccacg tcctcgtcga cgagtatcag gacgtgaacc gcagcagcgt
    16681 gcggcttctc cagcgtctga cggatggtgg agataacctc tgggccgtcg gcgatgcacg
    16741 gcaggccatc taccgattcc gtggcgcatc ctctttcaac atgtcgcgct ttaggtccaa
    16801 cgacttctcc ggtggcactg gcagtcggct ccggctcaac tatcggtcga cacccgagat
    16861 cgtcggggcc ttctcccgct tcggcgccac catgcaggct gggaccagcg acgcatcgct
    16921 cgatgcctat cgaccgtcca gcgggatagc gcccgagcat gtgaccttcg gcgacaatga
    16981 cgacgaggct gcggcgctcg ccgacgagat tctgcgctgc tcggaggacg tggccttccg
    17041 agagcaggcc gtgctctgct ccggaaacga ccggctcaac cgcatgggac gcgagctgga
    17101 acgtcgcgga atcccggttc tctatctggg aaatctcttc gagcggcccg aggtaaagga
    17161 cttgctgtcc atcctgtcac tgctcgtcga ccggcgtgca atgggcctcg tccgcaaacc
    17221 ctcgctgccg gatctggcga cgggcatcac cctgactggc gccgcggcgg tcgtcgacca
    17281 tcttcggctg accgaagccg acccactcgc atgggcgggc gcctccccgt cgctacaggt
    17341 tctcgatgcg gccgacatgg cggcggtgag caaagcatcg gccatggtga ccggcttcga
    17401 tagtcaatcg aatccctgga cagtgcttgc gcacgtcctc ctggaccgca cgcggactgc
    17461 ggcatcgctg gcttcgacgg ccgatgttgc cagccgatcg atgggcgtcg ccatctggca
    17521 gctcatgggt ttcctgcgtg ccgagcgtcc agcgccggaa ccgggacttc cagttcaacg
    17581 caccctcgat ggcataaggc gtctgatcca gctcgccgac gagagggacc ttcgccagct
    17641 gcctcaggct gcgcagggta tcgacgccgt ccggctcatg accatccacg gcagcaaggg
    17701 gctagaattc cccgtcgtgc atgtgatggg cctgaacaag aacagcatgc cgaacacctg
    17761 gcgaaagcct gcctgccctg tgccggatgg catgatcgag ggcggcaagg gtggcacgat
    17821 ggagatcagt gccgccgatc atgcgcttga gcaggagtgc ctcttctatg ttgccacctc
    17881 ccgcgcccgg gacaggctcc tcctctactc ggcaaggcac accaccacaa acgcaagacg
    17941 cgacccttcg ccattcattg gtcgactggg tgtcagcgtc gccagggcgg caatggcaac
    18001 cgcaacctca agccccgacc cggaggatct accgctgccg atcacgatgg ggtcagccat
    18061 caagatcacg atcgcacagc tgagcctcta tgatcggtgc ccgcggcgct tcctctacac
    18121 ccacgttctc ggggtcggcg gacgccgcac gcctacgacc atgacgagga tgcacgatct
    18181 ggtgcgcgcg gtcgtgacgg agatcgcctc cacgcagccc tcctcgacct cgctcgacga
    18241 aatggagaga ctgctggatg agcgctggtc cgaaggatca ttggccggtg acgagtatcg
    18301 gctgcaccgc gatgtggcag cgacgcttct tcggcgattc gtgaggatga gggcgggcac
    18361 gacccgcacg ggagccgcgg gcctgagggc gggcattgga actaacacga tcacggcgga
    18421 tgcggacgat gtcgtgacca ccgccagcgg ggcacattgc gtccgcatgg tgagaacggg
    18481 gcatagttcg tcgacgaccg ggaagagcct cgccgatgcc gccttccaga tggcggcctc
    18541 cgcatcgctc ccggggtgtg cagccgagat cattcacctt ggggatgacg atccatcgac
    18601 gtcggtttcg ttcagtccga agctgcttgg tacgaaggag gagaagctga ccgagttgtt
    18661 caagtccatt ggtggcggcc atttcgcacc tgagcgatcg ggtcgaacct gccccttctg
    18721 cccggccttc ttcacctgtg gtccagtggc agagggcaac ctccaaaaaa atctctgagc
    18781 gaaattaccg gtcggatccc gctgccgaga ttgaccctgt gagaccgccg caatcacgcc
    18841 tcggtccgca ggaacacacg acacaatgtc cattctcgaa aaccacgaca tcgatgatgt
    18901 agaactcgcc gtgcagcagg atcgcccgct gcgtcccggt cgctatcgcg tccatctggc
    18961 tgttgacagc attggcttca cccccctggt tcttgacgat ccggtgccgc tcggccgtca
    19021 gatcctcaag aaagcgggta ttatcgacct cgatggccac tcgctcttcc tcatcaggcc
    19081 cgagggcgac ttcgaggatg ttcgcgccga cgaggaggtc gatctgcgtg accgcggtgc
    19141 ctaccgcttc atcgcattca gcaccgatcc cctctaccgc gtcaagctga acgaggcacg
    19201 catcgtctgg ggccgctcgt ccatccccga ggcggtgctg cgtgcgctcg ccggcatcgg
    19261 cgacgacgag gcggtcttcc tggaggtgcg cggcggcaag gacaagctga tcaaacccgg
    19321 caccgaagcg gacctctcgg ccggtggcgt cgagaagttc atcacggcac ccaacaaggt
    19381 cacctacacc ttcttcgtca acggcaagcc ctatgagacc gagaagaaga agctgaccgg
    19441 tgcgcagatc aaggagatgg tgcccgactg ggatccgcag cacgatctgt cgctggaggg
    19501 tgaaggcgac gagcccgacc gcaccatcgc cgacgacgag gcggtgagcc tcgacccgaa
    19561 gcacggcgtc cgccgcttct cgtcggtgcc gaaggcgaac ttcggctgat gtccggcatc
    19621 ctcgatatgc agctggagca gctgcgggag cgcttcggcg acgttcagac ccggcgcttg
    19681 ccgagcggca ccacactcgt catcgtgccg ggtgtccgtc tgccggaggg gtggtcgaag
    19741 gtttcggcta ccatccgctt cattgtcccg ccggggtatc cgttcgcgca gctcgactgc
    19801 ttctgggcgg atcccgacct gcggctcgcc catggtggag tgccgcagaa ctctgcgacg
    19861 agccccattc ccgagacggt cgagccggcc ctgtggttct cgtggcatct gactggccct
    19921 tggaacgcca accgcgacac gctctcgaca tggatgaacg tcgtgatcga acgcatgagg
    19981 cagatccgat gagccgcgtc cgctttcccg cgcccctcta ttcccatctg gcgtcgaggc
    20041 tgctcgatgc caacggtctg gagagctgcg ccatcgctta tgcccatcac gatgggcata
    20101 gcgacacctg gatcgtcgcc gacgccagtc cagtgccaga ggacgcctat gagcgccgcg
    20161 accgcctgtc cgcggtgctc aagccttcct tcctggtcga ggtcgccaac cgtagccgcg
    20221 tcacaggaat ggcggtaatt gccatccaca cccacccggc cagccccggt tatacttgct
    20281 tctcatcgac cgacaatgca ggcgagacgg aactcagcac atacttcgcc cgccgcgcgg
    20341 ccaaggttcc gcatgtcgcg ctggtcatcg gacctgaggg atgccgcgcc cgcctactcg
    20401 gacaagaaga ggaggtcgag gtctgggagg tcggacagtc cctcacgctc cattcccctc
    20461 tcgcagacct cgcgaaccat gaacgggatg atcggcaggt ccgcgccttt ggcgcgcctg
    20521 gacagcgtct ggtgcgccgt ctccggttcg ccgtcatcgg tgccggtggc accggatcga
    20581 tcgaatgcca gcagctggcc catctcggcg cggca
//
