LOCUS       NZ_CP109848            24116 bp    DNA     circular CON 22-NOV-2023
DEFINITION  Paenibacillus polymyxa strain K16 chromosome.
ACCESSION   NZ_CP109848
VERSION     NZ_CP109848.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5978518)
  AUTHORS   Manfredini,A., Vitali,F., Sas,L., Trzcinski,P. and Canfora,L.
  TITLE     Genome sequence of the Paenibacillus polymyxa K16 strain isolated
            from soil of tomato roots
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5978518)
  AUTHORS   Manfredini,A., Vitali,F., Sas,L., Trzcinski,P. and Canfora,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-OCT-2022) Research Centre for Agriculture and
            Environment, CREA - Council for Agricultural Research and Analysis
            of the Agricultural Economy, Via della Navicella 2/4, Rome 00184,
            Italy
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2022
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 270.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 06:01:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,334
            CDSs (total)                      :: 5,275
            Genes (coding)                    :: 5,199
            CDSs (with protein)               :: 5,199
            Genes (RNA)                       :: 59
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 52
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 33 of 76
            Pseudo Genes (incomplete)         :: 52 of 76
            Pseudo Genes (internal stop)      :: 19 of 76
            Pseudo Genes (multiple problems)  :: 22 of 76
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:36:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5397382
            Orig. end                         :: 5421498
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP109848.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Strain stored in SYMBIOBANK
            culture collection of the National Institute of Horticultural
            Research in Skierniewice (PL).
FEATURES             Location/Qualifiers
     region          1..24116
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="14"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..24116
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24116
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14116](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14116)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(313..324)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.77"
                     /tool="antismash"
     misc_feature    345..358
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    367..382
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.38"
                     /tool="antismash"
     misc_feature    369..383
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.52"
                     /tool="antismash"
     misc_feature    complement(376..390)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.83"
                     /tool="antismash"
     misc_feature    complement(704..717)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.09"
                     /tool="antismash"
     gene            709..1893
                     /locus_tag="OF859_RS24275"
     CDS             709..1893
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429859.1"
                     /locus_tag="OF859_RS24275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_023987466.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.8e-05, bitscore:
                     22.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVALVSPLRTAVGSFNKTLAPLSAPELGATVMTACLQQSRLEP
                     SLIDQIYLGNVLQAGNGQNPARQAALKAGIPIDVPETTINTVCGSGLHAVALAYNSILA
                     EQGNIVLAGGMESMSNAPYLLRNARNGYKLGNGELVDSLVADGLTCPINHYHMGITAEN
                     VAEKYGISRLEQDEFSYQSQIKAVEAKNKKLFEEQIVPVMIKNKKETISFTEDEHIRGN
                     TTKEKLSQLKPAFKENGTVTAGNASGINDGAAAMLVVSEDKCKEHELKPLAYIKGYSLV
                     GVDPAYMGMGPVKAISSLLKQQGMSIDDIDLFEINEAFAAQALAVLKELGINPEKVNVN
                     GGAIAIGHPVGASGARVLVTLVHEMVRRSSRYGIASLCIGTGMGIAMLVENALI"
     gene            1949..2689
                     /locus_tag="OF859_RS24280"
     CDS             1949..2689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686439.1"
                     /locus_tag="OF859_RS24280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetoacetate decarboxylase"
                     /protein_id="WP_264454055.1"
                     /transl_table=11
                     /translation="MNQKDVLSLQSMPAASGSYGRPPCRFINREFFIITYESDPAAIRQ
                     AVPEPLQPDGSNTVSYEWIKMPDSSGLGSYEESGIVIPCTFHGEPCNFVAQMYLDNAPA
                     ILGGREIWGFPKKWAKPRLIVEETETLTGTLHYNNVLVATGTMPFKYNILDEKETAKAI
                     AKTQVNLKLIPDVDGTPKIAQLVAYNLENITVKGAWSGPARLNLIPHVNAPVADLPVKA
                     YIGGKHFIADLTLPYGRVLYDYLQ"
     gene            2730..3395
                     /locus_tag="OF859_RS24285"
     CDS             2730..3395
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429861.1"
                     /locus_tag="OF859_RS24285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CoA transferase subunit A"
                     /protein_id="WP_023987464.1"
                     /transl_table=11
                     /translation="MNNKVISAEEAVKQIKDGDTVMVGGFLAGGFPEELVRALVDTNPA
                     SNLTIISNDTGTPELSIYKLVKSGRVKRIFASYIGSNPETGRLLMTKEAEVQLFPQGTL
                     AEKIRAGGAGLGGVLTPVGVGTIVEEGKKKIQIDGREYLLELPLKADVALIRAHKADEA
                     GNLVINGSSRNFNLVMATAAEYVVAQTDEYVKTGEIDPNHVNVPGIFVDAIVKVGENA"
     gene            3392..4048
                     /locus_tag="OF859_RS24290"
     CDS             3392..4048
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369865.1"
                     /locus_tag="OF859_RS24290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-oxoacid CoA-transferase subunit B"
                     /protein_id="WP_023987463.1"
                     /transl_table=11
                     /translation="MNNREFIARRIAQEFKNGEVVNLGVGMPTMVVDYIPENIHIMLQA
                     ENGILGVGPKATQGKERLDCIDSGGNYVTTMEGACFFDSSLSFSIIRGGHVDITVLGAL
                     EVDEKGNLASWMIPGKKVPGMGGAMDLVVGAKRVIVAMEHVNKNGAPKILEQCKLPLTA
                     VNVVKTIVTEKAVIDVIPGSGLMLKEIAPGLSVEDVQLATEAKLMISPHLKAIAV"
     gene            complement(4288..4467)
                     /locus_tag="OF859_RS24295"
     CDS             complement(4288..4467)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309199.1"
                     /locus_tag="OF859_RS24295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="H-type small acid-soluble spore protein"
                     /protein_id="WP_023987462.1"
                     /transl_table=11
                     /translation="MNVERAKAIYDSSENIAVQLDGKPIWIEHVDQANGMATVQIGSRP
                     GNTQTVRVDRLEEQ"
     gene            complement(4524..4763)
                     /locus_tag="OF859_RS24300"
     CDS             complement(4524..4763)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369863.1"
                     /locus_tag="OF859_RS24300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_023987461.1"
                     /transl_table=11
                     /translation="MSGKSYPQQIRHRVGQSQIAFRGPAGGEQDALPPEFALSHGIRPP
                     FPVAVAHVDLEAVVSTSPSHSIPSLDVERIIDED"
     misc_feature    5245..5258
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.9"
                     /tool="antismash"
     misc_feature    complement(5385..5402)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            5591..6505
                     /locus_tag="OF859_RS24305"
     CDS             5591..6505
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309197.1"
                     /locus_tag="OF859_RS24305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Ku protein"
                     /protein_id="WP_013309197.1"
                     /transl_table=11
                     /translation="MHTVWKGAISFGLVHVPVKMFSATEDKDISMRYIHKECGSPLSYV
                     RKCPVCDKEVEWEEIGKGYEYEKGKFVMFDKEELEQVSGQADKNIVILDFVDLQEIDPI
                     YFQKTYYLSPDQAGSNAYKLLMNAMKDTGKIGIAQISIRSKSSLAAIRVLDECLAVETM
                     FYPDEIRPIAQVPNLPGQEEVKEKELTMAKMLIEQLSTPFDAAKYTDQYRERLLDLIQH
                     KVAGEEVRIAPTQPQTNVVDLMAALQASIEAVQPVVTDPGPAAKKRPARKPAAPTAQQA
                     VAGENISPTPVKKKRSTAKRKET"
     gene            complement(6528..8333)
                     /locus_tag="OF859_RS24310"
     CDS             complement(6528..8333)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821218.1"
                     /locus_tag="OF859_RS24310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_071559030.1"
                     /transl_table=11
                     /translation="MVHLRLYMTKLYSVNGGALFLNIGCMIIVSLLEGFGIYMLVPMLA
                     AIGVFVGHSGMPFLSGGLEHFLPFIPKSWLLPGMLMVFIVLLTGQALLQRYQSILNSRI
                     QQRFMRSLRIDVYTSFMKAQWAFYLRQRKSDFSHVMTTELARVSQGTNLLLQLTTAVMF
                     TMIQIALAFWLSPSLTGLVFLSGLGLFVVFRRSIRNAKQLGDRTTELSQVYFAGITDHM
                     NGMKDIKSNLLEAANIHWFRSLTQRMEDNTTQFVRQNATTQFFHRTAAAVFVACVIFTS
                     LQWLHVTPEKLIVLILIFSRLWPRFALIQASLEYIMSMISAFESVTKVQQECEAFTDPS
                     LIVSASVRQPLSLRHGIECSHLDYRYDGAAESALRQINLFIPARGMTAIVGKSGAGKST
                     MVDVLMGFLRPTGGQITIDGLVLDDELLLQWRQSFGYVSQDPFLFHATVRENLMLADKD
                     ASEQQLWEALHFAAADNFVSRLPEGLDTVIGDRGIRLSGGERQRLVLARAVLHHPSVLI
                     LDEATSALDGEHEAAIQAALERMKGQMTLIVIAHRLSTIRHADQIVVLDQGEVIQQGNY
                     HQLEQEERGAFSQLLSYQSSVTATP"
     gene            complement(8476..9972)
                     /locus_tag="OF859_RS24315"
     CDS             complement(8476..9972)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426482.1"
                     /locus_tag="OF859_RS24315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_264454056.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 3.8e-80, bitscore:
                     267.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTKSVLELANWNEDQELTLLFSLLGKDVSHWQDKTAATQLREMD
                     WVRFLRLTEHHRVVPTVYLQLKTLNHPFIPVELLRNLQAQYHRNTLRMLHLQAEAERLT
                     RLLIAHGIRVLMLKGPALAQQLYGDVSLRTSKDIDLLIAPDDMDEAEHWMKEAGYASKS
                     GEVRVLGSWKWKDHHASYLHPQKRVEIELHWRLHPDGGGEPSFDELWNCRKMGKAAGTS
                     RQVLLGPADNRTVMTSCMYTLSSEHQFLYLSAHGARHGWFRLRWLVDIDRLAVCAVDWE
                     ALLPMMCRYGGLPAGGQAWALAAALLGTPIPEPMRPASATRQAHRLALSALAFMQASVP
                     APYPIAHGPSTGRLAPSELLHSRALAEQAEAAPPDGGASVCGTCGEAAMLATSGVTSIT
                     EDASNADHSPMSTATSCAPITPAVASSQVMTRNTAAAHQPVSRTYLLSLKEPRHRLWYL
                     ISRLFPSTGDSAVFPLPRQLHFLYIPLRPFLWLKRRFSKH"
     gene            complement(10001..10486)
                     /locus_tag="OF859_RS24320"
     CDS             complement(10001..10486)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821220.1"
                     /locus_tag="OF859_RS24320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_023987457.1"
                     /sec_met_domain="PF13471 (E-value: 3.5e-24, bitscore: 83.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIQRLLLLSPEVRRLLPEAWLELGWARLRQRRSFGDYSRVWGIC
                     MEETPWKCDVRQEKCIKQISHAVELASRYTPWRSSCLVQAAAAMTLLGRRKLDCTLYLG
                     TAKNAAGRLAAHAWVRSGPIYVTGKREMEAFTVVGIFGRRAVTDTNTKMADKGSSLL"
     gene            complement(10488..10790)
                     /locus_tag="OF859_RS24325"
     CDS             complement(10488..10790)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309193.1"
                     /locus_tag="OF859_RS24325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_053324868.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.1e-25,
                     bitscore: 85.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.7e-16, bitscore: 58.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAATNSAKDHYRVIYGEEVYVSDMDGEKVMMSINTGKYYNLGFTG
                     GRIWELAESGPSLGDIVTVLTNEYEVDEEQCRQQVHTFVAELEREGLLKLLRESV"
     aSDomain        complement(10509..10742)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_OF859_RS24325_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.20E-27"
                     /identifier="RREFam002.1"
                     /label="OF859_RS24325"
                     /locus_tag="OF859_RS24325"
                     /protein_end="94"
                     /protein_start="16"
                     /score="85.4"
                     /tool="antismash"
                     /translation="EEVYVSDMDGEKVMMSINTGKYYNLGFTGGRIWELAESGPSLGDI
                     VTVLTNEYEVDEEQCRQQVHTFVAELEREGLLK"
     gene            complement(10777..11820)
                     /locus_tag="OF859_RS24330"
     CDS             complement(10777..11820)
                     /EC_number="2.7.1.24"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010349787.1"
                     /locus_tag="OF859_RS24330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dephospho-CoA kinase"
                     /protein_id="WP_053324867.1"
                     /transl_table=11
                     /translation="MHDRSANVSWTKYIAFGLRIASELNLPELILAAPEAVEDVVIRQA
                     DLTAWSGQLEQANFVMLDERFMFQIPGTAIYAVREGKEIEVSIFSGADPDTVRLFVLGT
                     CMGVLLMQRRILPIHGSAVVIGGRAYAFVGESGTGKSTLAAAFRQAGYQMVSDDVIAVK
                     ATASSAIVYPAYPQQKLGLDSLLQLEALRENKHARKRNNIRSLTDDNSVMPQYSDLRML
                     AGELNKYAVPAVDEFFNDPLPLGGVFELVADSPIRALMREGELVAVTEQPLNVLECLHT
                     LLQHTYRRVIIPRMGLSEWSFDTAARMARKVEGWRLLRDSSVFTASEVVQRVLDIIRKE
                     EKSYGSH"
     gene            complement(12010..12138)
                     /locus_tag="OF859_RS24335"
     CDS             complement(12010..12138)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369856.1"
                     /locus_tag="OF859_RS24335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_023987454.1"
                     /transl_table=11
                     /translation="MSKKEWQEPTIEVLDINQTMAGKGWKQIDWVSDHDADLHNPS"
     gene            complement(12191..14116)
                     /locus_tag="OF859_RS24340"
     CDS             complement(12191..14116)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369855.1"
                     /locus_tag="OF859_RS24340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_076157926.1"
                     /sec_met_domain="GATase_7 (E-value: 6.8e-21, bitscore:
                     72.7, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.2e-25, bitscore:
                     89.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIAGIYSFGHESVSTEEGGKMMQALRKYPADRVCAWCEGSIFL
                     GCHAQHVTPESVHERLPFYDELRDLAITADAIIDNRSELFERLGVEQERRQDITDSELI
                     LLAYDKWGVEAASYLIGDFAFVIWDAKEHRLYGARDMTGNRTLYIYQHDRGFAFSTVVA
                     PLLALSSLRKELHEPWLAEFLSIRAMQESVDIGTTAYKHINQLPPAHWFTMEEGKRTLH
                     KYACLDEVEPLRLKTGGEYIEAFREVFTQAVTARLRTHRAVGAALSGGLDSGAVASFAA
                     PSLHLQQKPLHAYSYVPVQDFTDWTPPTLLANERSYIQSTARYVGNIHENYMDFEGKSP
                     FSEIDIWLELMEAPYKYFENSFWIRGFYEKAQEHNVGVLLTGARGNFTVSWGPALDYYA
                     RQFRRLHWLQSFQGLWRYSKLTGRRMSHLLPVMLKKATSLESRSWLRRSNRSPVPSLIH
                     PEFAKRMHVEDIPVLSGTGWMKNADQTRKEKFSNLAIANKNGVVATKLSLRYGLWERDP
                     TGDSRVIRFCLSVPFEQYVQNGRDRALIRTAMRDHLPDDVRLNQRVRGVQPADWLHRML
                     PCWDTFMGELQLMCHDLRAAEYLNIEFIKTAMAKLHHPRPEQASDPNIRLLMHSLIVYR
                     FLCRLN"
     gene            complement(14113..15381)
                     /locus_tag="OF859_RS24345"
     CDS             complement(14113..15381)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309190.1"
                     /locus_tag="OF859_RS24345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfotransferase"
                     /protein_id="WP_264454057.1"
                     /transl_table=11
                     /translation="MIEKQGGGLVFLLSVPRSGSSLLTAILQNHSRLFATQEMWFLLSL
                     YDLPQSHVRPYGGTGILRQFFKGMVPSDVLEQASRSYALEIYNGLLQGTTADMLIDKSP
                     RYYTVLEFIDRLFPDARRLWLIRNPLAIVASFKKVNQLRNGRFQLLEELGSPHFNMKMT
                     DITVGLFRYAHYFATPHPLAYPLRYEQLVSNPTMEIEKLCSFLGIKYEPGMEKYGDFAD
                     TPKSSLFYSMGAGDPFVGEHEQAHQDSVHSWQHLLSKTEIELYCRSIGSRMFRQLGYAE
                     ALEQAEQMTGVRFEDEPDIELLSQRTQQFLQQSGFEWKAAYRMLEDRDADNRELVINAT
                     RHTVPQDLARMEVDQIVNDRRIQSLENRLAHSYEERNRLIAQLQSYQRPNQGLRSRSLF
                     ARKLGRLASVALSSIGKEKGGRT"
     misc_feature    15432..15445
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.22"
                     /tool="antismash"
     misc_feature    complement(15434..15447)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.35"
                     /tool="antismash"
     misc_feature    complement(15435..15448)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.44"
                     /tool="antismash"
     gene            15595..16497
                     /gene="ligD"
                     /locus_tag="OF859_RS24350"
     CDS             15595..16497
                     /EC_number="6.5.1.1"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369853.1"
                     /locus_tag="OF859_RS24350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_013309189.1"
                     /transl_table=11
                     /translation="MGQAVKGTITIEGQEIPITNPDKPLWPEAGVTKALYLRKLAVLAP
                     FLLKYCHHRLLTVIRWPHGIHGDFFYQKNAPRPRPDYIETALHDGIEYIVLGKLPQLLW
                     LGNQAALEFHPSLHEAGSKLPCEWMIDLDPSREVEPRIMEAASIVGEVLASLGLDSVPK
                     TSGATGVQIIVPIRTGITFDELRSIGLLVGQFVTEKHPHLFTLERLKKDRGTAIYFDYL
                     QHYQGKTLAAPYTPRARPGATVSTPLTWEEVRQDVSPLDYHLLNIEERLNQVGDLIDKV
                     PPQPVEDVLKHMRTKAHRT"
     gene            complement(16567..17511)
                     /locus_tag="OF859_RS24355"
     CDS             complement(16567..17511)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280287.1"
                     /locus_tag="OF859_RS24355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YitT family protein"
                     /protein_id="WP_023987451.1"
                     /transl_table=11
                     /translation="MSVVSKEVQNLSEITDVTGELTKISKIPANPKNKAKRLFQRAAMI
                     IFGATLMAVGLEIFLVPNGVIDGGVTGISIMASKITGYPLGIFLTLLNLPFLLIGYKQI
                     GKTFALSTLFGIIVMSIGTALLHNVSALTPGEPLLGAIFGGVILGVGVGLVIRSGGSLD
                     GTEIVAILVSEKTPFSVGEIVLFVNIFILGSAGFVFGWPNALYSMIAYYIAMKMIDITI
                     EGLDQSKSVWIISEKYRDIGDALTDRLGRGVTYLEGEGGFTGESKKVIFVVITRLEEAK
                     LKSIVEDWDPHAFVAIGNIHDVKGGRFKKKGIH"
     gene            complement(17707..19137)
                     /gene="cls"
                     /locus_tag="OF859_RS24360"
     CDS             complement(17707..19137)
                     /GO_function="GO:0008808 - cardiolipin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032049 - cardiolipin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cls"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686424.1"
                     /locus_tag="OF859_RS24360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cardiolipin synthase"
                     /protein_id="WP_028543093.1"
                     /transl_table=11
                     /translation="MLWLLLVLIVFIFQTGTILLFEFRKPSKAVAWLFILFCFPLIGFV
                     VYYFVAQDYQKRKMVRKGGSQLFREFRERLWAQSKVIEHVEQMHNPHFKHQERLFNQLI
                     RMSENPLTGCNRTRVLTNGEETFEAMLTAMEHAQHHIHVEFYIFRADEIGRKFQEVMIR
                     KAREGVKVRFVVDGVGSYHLPYSFIRTCSEAGVEFHYFLPPFFATLDRRINYRNHRKIV
                     VVDGMIGFVGGINVGDDYLGKYPKVGFWRDTHLQIEGDSVYFLQNAFLSDWKLASGERL
                     MDVNLFPPHTCTGDEEVQILSSGPDQVWDTIQEMCFGALTVAKKRIWITTPYFIPDLGI
                     YEALKLAAVSGVDVKIIIPYQSDSKLVHLASLSYVQELLEAGVEFYQYRKGFIHAKVVI
                     VDDLLGSVGTANMDMRSFFYNFELTAIVFANSALERLSEDFVEDISNSSRIDLNVFRRR
                     PRSQKIAEILTRMLSPLL"
     gene            19284..20315
                     /locus_tag="OF859_RS24365"
     CDS             19284..20315
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426474.1"
                     /locus_tag="OF859_RS24365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_028543094.1"
                     /transl_table=11
                     /translation="MKKGSLNRRMTLLVIRDAQQPPKQLQCSTAAVILVPTLVIASIST
                     LVIGLQIHSSHIISQMETNLAVQSLQMEVTVADKDAAIGRLRQEVMELTNQATNIRERL
                     QRVTELEQQMQQFIRKHGNSSATSNHKKTMTPLSWDASGHIGGELIAVHENTALLTRQA
                     MDDFQEIESLLDTVERTVPRSIQQANAVQQNLERKQAAQLLQTRRLALAEQGNPSVWPV
                     GSRRMTSSFGYRSDPFTGRSAFHSGVDIAGQTGDPVYAAGAGTVLEAASSGARGKCIII
                     QHPDGLQSWYMHLSGMQVAPGDRVHKGQTIGLLGSTGRSTGPHLHFQIVKHNQPVDPLL
                     YVQ"
     gene            20361..20822
                     /locus_tag="OF859_RS24370"
     CDS             20361..20822
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369848.1"
                     /locus_tag="OF859_RS24370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polymer-forming cytoskeletal protein"
                     /protein_id="WP_053324862.1"
                     /transl_table=11
                     /translation="MFKESKKKLSAPAMDTLLANGTSFEGTVEAEANIRIDGHFQGDIR
                     STRTVVIGESAVVRSDIIAQDVILAGKVFGSITTEGRLTITPTGELYGNTATTALVISE
                     GGILDGTIQMNRTKDVELSTSTDESNDETQSSFSKNKEDSQAALQSEAG"
     gene            complement(20862..21947)
                     /locus_tag="OF859_RS24375"
     CDS             complement(20862..21947)
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426473.1"
                     /locus_tag="OF859_RS24375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AI-2E family transporter"
                     /protein_id="WP_023987447.1"
                     /transl_table=11
                     /translation="MLQNNRFFRLTTGIVMLLLIIYLGTKVSFIFSPLVSLVSLLVVPL
                     MLSFFLYYLLRPIVDVMERRKIKRSISILLIYLVIGVLLFVFSWGVWPTLRDQVTNLFE
                     NAPKLIKSLVDQLSQWRHNQSLRQVLPPGEDPLSQLSDTLNEAFSTLSDYSVKLVSFVS
                     YFFIVLATFPILLYYMLKEGSKFGPKMLNFFPKKYHKDALEVMEDIDSALSSFIVSRVL
                     INVALGVMMFLGFLIIGLPYALLLAVISIFLNFIPYVGAVAASIPVVIIGLLESPSMAL
                     WSLVVVIAAQQIQDNWLSPIVFGKQLDIHPLTVVILLLVGGDLLGILGIILVIPLYMCG
                     KIVIRKVYQLFLERRVEDIME"
     misc_feature    complement(22021..22037)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.86"
                     /tool="antismash"
     gene            complement(22190..22972)
                     /locus_tag="OF859_RS24380"
     CDS             complement(22190..22972)
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369846.1"
                     /locus_tag="OF859_RS24380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_071559036.1"
                     /transl_table=11
                     /translation="MGDFFKLVHNENLKIYLRVRTWIMLGLLAVITAVIPMLISLVSDQ
                     VSVWDGIALTTLFTFFLNTTFTVIVAADSVAGEFTWGTIKLLLIRPWTRSKILLSKYLS
                     VILFSLLGTIILILMVTLSSWLMLSKDAPAGSVPLFSDPISYVTLNFLYSYIALFVTMA
                     FAFMLSAVFRSSALAIGLSLFMMFTKTVYNTIGLFSTDRFEWTKYVLFTHMDLKKYLDM
                     PPGTVSSSLTFSLTVLAAYYVIFIAIAWVVFVKRDVST"
     gene            complement(22965..23885)
                     /locus_tag="OF859_RS24385"
     CDS             complement(22965..23885)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821230.1"
                     /locus_tag="OF859_RS24385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023987445.1"
                     /transl_table=11
                     /translation="MQQATGQVPVIRMEGVSKIISSKAIVDDLTLEVPAGQVFGFLGPN
                     GAGKTTTIRMMVGLISISKGDIHICGDSINTDFEKAVAHVGAIVENPEMYKFLTGYQNL
                     QHFARMSPGVTQERVEEAIRLVGLGNRIHDKVKTYSLGMRQRLGVAQAILHRPKLLVLD
                     EPTNGLDPQGIRELRDYLRQLTRTEGITVFVSSHLLSEMELMCDRVAIIQSGRLVDIKQ
                     LKNTGEEVQKAEIAFEVNDAEQAYALAGAGRVEGNQLLLHLEREQIAEMNSLLAANGIK
                     VYAIRPVARTLEDQFLEVTGGGVIG"
     misc_feature    24094..24107
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
ORIGIN
        1 gtgctgagca gtgaacaaat tgtagcgcat cataatggga tgcttggcaa tcgttttgtg
       61 cgtttactcg cgacagcgga tgtacatttt tcgtgagttg ttgaagtttt atgttccaag
      121 ccgattgctt tcaagcaagt cggcttcttt tattgttcat acgaaaaaac cgccctttca
      181 agtgacaccg ttaacaagaa gcaagctggc acaatataac gaagattatg aatattgaaa
      241 ggcaaatccg tcttcagaac attctggagg ctttttttat ttcccagcga tgagttagat
      301 gatatttgcg aggaaaactt tttcacgtat ggattgtaac tttcattttt aacagaaaat
      361 tcaatttatg atcattattt tcagaaaaat taagaaatta acagaaaacg ttagaatggc
      421 ctaattattg tggcctatat ggctctataa acatctgtac atagatatgt gtatattttt
      481 gaacattgag caaaatctgc attagaacta tgatgaaact ggttttaatt tccaacgaga
      541 gaaggcgatc gaaccctcac actcactgtc ttaggcacca tgatatgccc gcaagcaaat
      601 gtatcttgca gtcgctacat ctcgtaggtt aagaacggaa attacgaatt gaagtgcaat
      661 catggatgta ttgtgtcttg aacacaacga aaggaatgtg agtttttaat gaaaaaagta
      721 gctttagtaa gcccgttgag aacagcggtc ggctctttta acaaaaccct tgcgcctcta
      781 agcgctcctg aactgggagc aactgtgatg acagcatgcc ttcagcaaag tagattagag
      841 ccttctttga tcgatcaaat ttatttggga aatgttcttc aggcgggcaa tggccaaaat
      901 cctgccagac aggcggcact aaaagccggt atccctattg atgtacccga aacaacgata
      961 aacacggttt gcggttcagg actccatgcc gttgctttag cctacaattc aatattggcg
     1021 gaacaaggca acatcgtctt ggccggaggc atggagagca tgtcgaatgc cccttacctg
     1081 ctaaggaatg caagaaacgg ctacaaactt ggcaacggtg agttggtaga ctccctggtg
     1141 gccgacggtc ttacgtgccc gatcaaccat taccatatgg gaattaccgc agaaaatgtt
     1201 gcagagaaat atggaatttc aagacttgag caggatgaat tttcctatca aagccagata
     1261 aaggccgtag aagctaaaaa caagaagctt tttgaagagc agattgttcc agtcatgatc
     1321 aaaaacaaaa aagaaactat ttctttcacg gaggacgaac acataagagg aaatacaacg
     1381 aaagaaaaac tttctcaatt aaaacctgcg tttaaggaga acggaacagt taccgccgga
     1441 aatgcttcag gaatcaatga tggcgcggcg gctatgcttg tagtgtcgga agacaaatgt
     1501 aaggaacatg agttaaagcc gttggcatat atcaagggtt attcacttgt tggcgttgac
     1561 cctgcatata tgggaatggg accggtgaag gccatttcgt cacttctgaa gcaacaggga
     1621 atgtctattg atgacatcga tctttttgaa attaatgaag cgttcgccgc acaagcacta
     1681 gcggtattga aagagcttgg aatcaatcct gagaaggtga atgtcaatgg cggcgcgatc
     1741 gcgatcgggc atcctgtcgg tgcaagcggt gctagggtat tggttacgct ggttcatgaa
     1801 atggtgcgga gatcttcacg ttacggcatc gcctcgttat gcatcggaac gggaatggga
     1861 atagcgatgc tagttgaaaa tgcactcatt taaagtgcga gttcaggatg acttttagaa
     1921 ctatctctta aaaggaaggg agatcgctat gaatcaaaaa gatgtacttt cactccaatc
     1981 catgcctgcg gccagcggca gttatgggcg cccgccatgt cgcttcatca accgggaatt
     2041 tttcatcatt acctatgaat ccgatcccgc tgcgattaga caggcggtcc cggaacctct
     2101 tcagccggat ggaagcaata ccgtttccta tgaatggatc aagatgcccg attcatccgg
     2161 gttaggaagc tatgaggaaa gcggtattgt cattccgtgt acttttcatg gagaaccctg
     2221 taattttgtt gcccaaatgt atttggataa cgcgcctgct attctgggag gacgtgaaat
     2281 ctggggattt ccgaaaaaat gggcgaagcc ccgcttgatc gttgaggaga cggagacgct
     2341 gacgggtaca ttgcattaca acaacgtcct ggtggccacg ggaaccatgc ctttcaaata
     2401 taacattctt gatgaaaagg aaacggctaa agccatcgca aaaacgcaag ttaatttaaa
     2461 attaattcct gatgttgacg gtacccctaa aattgctcag ttggtagcgt ataatctcga
     2521 aaacattacg gtaaaaggcg cctggtcagg gcctgcgagg ttaaacctga ttccccatgt
     2581 caacgctcct gtggcagatt tgccggtaaa agcttatatt ggcggaaaac attttattgc
     2641 cgatttaacg cttccatatg gaagagtcct ctatgattat ctccaataaa gttgctttcc
     2701 taaaaatata tatataagga gaaggaacca tgaataacaa agtaatctcc gctgaagaag
     2761 cagttaagca gatcaaagac ggagacaccg ttatggtcgg aggttttctg gcaggaggct
     2821 ttccggagga acttgtacgt gcgcttgtcg acaccaatcc cgccagcaat cttacgatta
     2881 tatccaatga tacaggcaca ccggaattat ctatttataa gcttgtaaaa agcggcagag
     2941 taaagcggat ttttgcatcc tatattggct ctaatccgga aacgggaagg ctcctgatga
     3001 cgaaagaagc ggaggttcaa ctcttcccgc aaggtacgct cgctgaaaaa atacgtgcag
     3061 gaggagcagg cttgggcggt gttttaacgc ctgtaggtgt aggcaccatt gtagaggaag
     3121 gaaaaaagaa aatccaaatt gacgggagag aatatttgct cgaactgccg ctcaaagcag
     3181 atgtggcgct aatcagagct cataaggctg atgaagcggg aaatcttgtc atcaacggct
     3241 cttcacgtaa cttcaatttg gtaatggcta cagcggcaga gtatgtagtt gctcagacag
     3301 acgaatacgt aaagacggga gaaattgacc ccaatcatgt caacgttccc ggaatatttg
     3361 tcgacgcaat tgtaaaggtg ggtgaaaacg catgaataac agagaattca ttgctcgaag
     3421 aatagcccag gaatttaaaa atggcgaagt tgtcaacctt ggtgttggaa tgcctacaat
     3481 ggtggtagac tatatccccg aaaacattca tattatgctg caggctgaga acggaatcct
     3541 cggtgtaggc ccaaaagcga ctcaggggaa agaaagactc gattgtatcg attcaggcgg
     3601 aaactatgtt acaactatgg aaggagcttg ctttttcgac agttcgcttt cattttctat
     3661 catccgtgga gggcatgtgg atatcaccgt gttgggcgcc ctggaggtcg atgagaaagg
     3721 caaccttgca agctggatga tcccagggaa aaaggttccg ggcatggggg gagccatgga
     3781 tttggtggtc ggagccaaga gagtgattgt agccatggag catgtgaaca aaaatggagc
     3841 gccgaaaata ctggaacaat gtaaactgcc cctcaccgct gtaaatgttg taaagaccat
     3901 cgtaaccgaa aaggctgtca tcgatgttat tccaggtagt ggactgatgc tgaaggaaat
     3961 tgcgccgggt ttatcggtgg aagacgttca attggcaact gaggctaaac tgatgatttc
     4021 accacattta aaggccattg cagtataaag tcatgtaaag gaaccaactc caccttcaaa
     4081 ttaacttgtc tggcgtttaa cttgttccct cgactgcatt tattattaca aataaggttc
     4141 gctaattgct cattgagcaa ttgcgagcct tttagggttg aagcgggatc attcaagcag
     4201 cattctacga tgaaagccta cagctgtcca agatctttct aaagctatac cccatactat
     4261 gggaaaaatc tggtttggtg ccctcttcta ttgttcttcc agacgatcca cacggacggt
     4321 ttgggtattg ccgggtctgc tacctatctg taccgttgcc ataccgtttg cttggtctac
     4381 atgctcaatc cagatcggtt taccatccaa ttgtacggca atattttcag atgaatcata
     4441 aatagctttt gctcgttcca cgttcatgtt attcttcccc tcctgtttgt tgttgtgtgc
     4501 attcattcag aaatatagtt cacctagtct tcatctataa tccgttcaac gtctaatgaa
     4561 gggatgctat gagaaggcga agttgaaact acagcctcca aatccacatg agccacagct
     4621 acgggaaaag gcggacggat tccatgtgaa agagcaaact cgggcggcaa tgcatcctgt
     4681 tcgcctccag ccgggccccg aaaggcgatt tggctttgac ccacacgatg cctgatttgc
     4741 tgaggatagg attttccgga cataaattgt gtaccccctt ttgaatcgga tatgccttac
     4801 tatgcaccaa acttgctgta accatgcgca cgcggaagca attcgcagtc ttcattcaca
     4861 actcatacaa atcctttgta cgaaacataa aaatgatttg ctcacagcca aggcgttgga
     4921 atcgaaggat gcagatgcgg atagctcgtc actatgggat gctcggtaat cttttagtgc
     4981 gtttgcttgc gacgacggat gtacattttt cgtgaattta aacataaaac agccccagct
     5041 tctcacgaag accggggcta tctatgattc catcccataa atgaggtgcg tattattttt
     5101 atgctttagc tgcccaaatt tcaatttcaa tttttatttc aggcaatcct agagcagtaa
     5161 ggtagccgaa atcgacctcg tcatttttaa atttttctac cgtttcttct aaccattttt
     5221 aggcagactc caccaataaa aatgatttta gaaaaaaaca gcagtagagt atccatatcc
     5281 aaaagatata aagtttaatg atcttttctt catgacatga acactccttt ctttaaaatg
     5341 tcaaaatcgt tgtttatccc ttatcttaat ataactaatg taacttaaca acttcatatc
     5401 attgtgttat gcgatgtagt catacctcag aatgcagatt agttggctcg ctcttttctt
     5461 tacacctcat acattccttt ctccgaagca tactaagtga aaaatctaag tgaaaaatgg
     5521 atatgctcac agccgagcgt tggaatcgaa ggatacaaaa tgcggattaa agaaaaggag
     5581 gagcggcgta atgcatacag tctggaaagg tgcgatcagc tttgggctgg ttcatgtgcc
     5641 cgttaaaatg ttttctgcga ctgaggataa ggacatttcc atgcgttata ttcacaagga
     5701 gtgtggaagc ccacttagct atgtacgaaa gtgtcccgtt tgtgacaagg aggtcgaatg
     5761 ggaggaaatt ggaaaaggat acgaatatga aaaaggaaaa tttgtcatgt tcgacaagga
     5821 ggaactggag caagttagcg gacaagcgga taaaaatatt gttattttag attttgtgga
     5881 tttgcaggaa attgatccga tttactttca gaaaacgtat tatctgtccc cggatcaagc
     5941 tggctccaat gcgtataagc tgctcatgaa tgcgatgaag gataccggga aaatcgggat
     6001 tgcccaaatc tccatccgct ctaaaagcag cctggcggct attcgggtgt tggatgaatg
     6061 tttggcggtg gagacgatgt tttaccccga tgaaattcgc cccattgctc aagtgcctaa
     6121 cttaccgggg caggaggagg ttaaagagaa ggagctgacc atggcaaaaa tgctaatcga
     6181 gcagctatct acaccttttg atgcagcaaa gtatacggat cagtaccgcg agcgtcttct
     6241 ggatctcatt caacataaag tggctggtga agaggtgcga atcgccccaa cacagcctca
     6301 gaccaatgta gtagatttaa tggccgccct tcaggccagc atcgaggcag tgcaacctgt
     6361 cgttaccgat cccggccctg ctgcgaaaaa acgccctgcg cgtaaaccag cggccccaac
     6421 agcacagcag gctgttgcag gcgagaacat ctctccgact ccagtcaaaa agaaaagaag
     6481 cactgccaaa cgtaaagaaa cttaagctga gttacagaaa agtctggtta aggggtggcg
     6541 gtgacactgc tttgatacga tagtagctga ctgaacgccc cccgctcctc ttgttccagt
     6601 tggtggtagt tcccctgctg tatgacctcg ccttgatcca gtacgacaat ttgatccgca
     6661 tgtctgatgg ttgacaggcg gtgagcaatg acgatcaacg tcatttgacc tttcatccgt
     6721 tccagtgctg cctgaattgc ggcttcatgc tcaccatcca gcgcacttgt cgcttcatct
     6781 agtataagta ccgaaggatg atgcaagaca gcccgtgcta atactagccg ttgacgttct
     6841 cctccagaca gacgaatccc gcgatctcca attactgtgt ccagcccttc gggcaatctg
     6901 gatacaaagt tgtctgcggc ggcaaaatgt aacgcctccc atagctgctg ctcactagca
     6961 tccttatctg ccagcatcaa attttcgcgg acagtcgcgt gaaataaaaa tgggtcttgt
     7021 gacacgtagc caaacgactg ccgccactgg agcaacaatt cgtcgtccag aacaagcccg
     7081 tctattgtaa tctgcccccc agttggacgt aaaaaaccca tcaggacatc gaccattgta
     7141 cttttacctg ctcccgattt ccctacaatg gctgtcattc cccgagcggg tatgaacaag
     7201 ttaatttgac gcagcgcaga ctctgctgca ccatcgtagc gataatccag atggctgcat
     7261 tcgatcccat gacgaaggga caggggttgc cgtacagatg cagatacaat caatgacgga
     7321 tctgtgaaag cttcgcactc ctgttgcacc ttggtgacac tctcaaaagc ggagatcata
     7381 gacatgatgt attccagact cgcttgaata agagcaaatc ggggccataa gcgtgaaaat
     7441 ataagaatca gcacaatcag tttttcagga gtaacatgca gccactgcag cgatgtaaat
     7501 atgacacaag cgacaaaaac agctgccgct gtacgatgaa aaaactgtgt ggtcgcattt
     7561 tgccggacaa attgggtcgt attatcctcc atgcgttgtg tcagggagcg aaaccaatgg
     7621 atattcgccg cttccaacag attgctttta atatctttca tgccgttcat gtgatccgta
     7681 atcccagcaa aataaacctg cgacagctca gtggtacgat cacctaattg tttggcattt
     7741 cgaatggagc ggcggaacac gacaaacagc cccaatccac tcagaaatac cagcccggtt
     7801 aaagaggggg ataaccaaaa agccaacgca atctggatca tcgtaaacat gacagcagta
     7861 gtcagttgaa gaagcaaatt cgttccctga ctgacacgcg ccagctcggt cgtcatcaca
     7921 tggctaaaat cagatttacg ctgacgcaaa taaaatgccc actgcgcctt cataaaggaa
     7981 gtgtacacgt ctattcgcaa agagcgcata aaacgctgct gaatccgcga attcaggatg
     8041 gattggtaac gctgaagcaa agcctgccct gtaagcagca ctataaaaac catcaacatc
     8101 cccggcaaca gccagctttt aggaatgaac ggcaaaaaat gttccaatcc accagacaga
     8161 aatggcatcc ctgaatgacc aacaaatacg ccgatagccg ccagcatagg aacaagcata
     8221 taaatgccaa aaccctccag caggctgaca atgatcatac atccaatatt gagaaataac
     8281 gcaccgccgt tcacgctata cagctttgtc atatataatc gcaggtgaac cataatgcac
     8341 actccttatc caggattttg aaaaattcga ttccagtcgc tccaaagtgc aatatataga
     8401 cgaactagac catttcgatc tatatattgt tcattgaaag tcgcttattg gatttttgca
     8461 aaatcctcta tcgagtcagt gctttgaaaa tcgccgcttc agccaaagaa atggacgtaa
     8521 agggatatac aaaaaatgca gctggcgagg cagtggaaaa acggccgaat cccccgtaga
     8581 aggaaacaaa cggctgatga ggtaccatag tctgtgtctt ggctctttta aggaaagcaa
     8641 gtaagtgcgg ctgaccggct gatgggcagc cgccgtgttt ctggtcatga cttggctgga
     8701 ggcgacagct ggagtaatgg gggcacaact ggtagcagtg ctcatcgggc tatgatcggc
     8761 gttactggca tcttccgtga tgctagtaac gccactggtg gcaagcatgg ctgcttcgcc
     8821 acaggtaccg cataccgaag caccgccatc cggaggggcg gcctccgctt gctccgccaa
     8881 agctctgcta tgcagcagct ctgatggagc aagcctacct gtactcggcc cgtgggcaat
     8941 cgggtacggt gcgggaacgc tggcctgcat gaaggccagc gcgctcagcg cgagcctgtg
     9001 cgcctgccgg gtagccgatg ccggacgcat cggctccggt atcggcgtac ccaacagcgc
     9061 agcggcgagt gcccaagcct gccccccagc aggcaggccc ccgtagcggc acatcatcgg
     9121 cagtagcgcc tcccaatcga cagcacatac cgcaagcctg tcgatgtcaa ccagccagcg
     9181 tagcctgaac cagccgtgac gcgcaccatg cgcgctcaag tacagaaatt gatgctcgct
     9241 gctcagcgta tacatacagg acgtcatcac agtcctgttg tcggcaggtc ccaacaatac
     9301 ctgccgactg gttcctgcag ctttgcccat tttccggcag ttccacagct cgtcaaaaga
     9361 gggttcccca cccccatccg ggtgaagccg ccaatgcagc tcaatctcta cccgtttttg
     9421 cggatggagg taggatgcat gatggtcctt ccatttccaa cttccaagga cacgcacttc
     9481 tccgctcttg gacgcatatc cggcttcctt catccaatgc tcagcctcat ccatatcgtc
     9541 aggggcaatg agtaaatcta tatccttgga ggtacgcaga gaaacatccc cgtacaattg
     9601 ctgcgccaga gcaggaccct tcaacataag cacacgaatt ccatgagcta tgagcagcct
     9661 ggtcagacgc tcggcttctg cttgaagatg gagcatgcga agcgtgtttc gatgatactg
     9721 cgcctgaagg tttcgcaaca attctacggg aatgaacgga tgattcaatg ttttcagctg
     9781 gagatacacc gtaggtacca ctcgatggtg ctcggtcaga cgtaaaaagc ggacccaatc
     9841 catctcacgc agctgggtag cagcagtctt atcctgccaa tgagaaacgt ctttccccaa
     9901 tagagagaat aacaacgtta attcttgatc ctcattccaa ttcgcaagtt ccaaaacaga
     9961 cttggtgggc atgcattctt ctccttcttg tctcatcgca ttaaagtaaa gaactacctt
    10021 tatctgccat ctttgtattt gtatccgtca cagcacgtct cccgaatatc cccaccaccg
    10081 taaatgcttc catctcccgt ttccccgtaa cataaatcgg tccgctacgt acccatgcat
    10141 gtgcggccaa gcgtccagcg gcatttttgg ctgtgcccag atacagcgtg cagtccagtt
    10201 ttctgcgccc cagcaacgtc atcgccgcag cggcttgtac aagacaacta ctgcgccaag
    10261 gagtataacg gcttgccagc tccacagcgt gcgaaatctg cttaatgcac ttctcctgcc
    10321 tgacatcaca cttccatgga gtttcttcca tacatatgcc ccaaaccctt gagtaatccc
    10381 caaaagaacg acgctggcgc aacctcgccc atcccagctc cagccaggct tccggcaaca
    10441 atctcctaac ctctggagac aggagaagaa gccgttgtat ccgcatgtta taccgactcc
    10501 cgtagaagct tcaacagtcc ttcccgctcc aactcagcca caaaggtatg tacctgttgt
    10561 ctgcactgtt cctcgtccac ctcatattca ttcgtcagga cagttacgat atcgccaagg
    10621 gaaggaccgg attctgccag ttcccagatt cgtcctcctg tgaagcctaa gttataatat
    10681 ttaccagtgt taatgctcat catcactttt tctccgtcca tatcactgac atagacctct
    10741 tcaccgtaaa tgacgcgata atggtcttta gctgaattag tggctgccat aactcttttc
    10801 ctccttacga atgatatcaa gtacccgttg tacaacctcg gacgcagtaa agacggaact
    10861 atccctcagc agccgccagc cctctacttt acgagccatc ctagccgctg tatcaaacga
    10921 ccattcactc aaacccattc gcggaataat caccctacga tatgtatgtt gtagtaatgt
    10981 atgcaagcac tccagaacgt tcaagggctg ttccgtaacc gccactagct ccccttcgcg
    11041 catcaacgca cggattggag aatctgccac aagctcgaat acgcccccta agggcagcgg
    11101 atcgttaaaa aattcatcta cggcgggtac ggcatattta ttcagttcac ctgcaagcat
    11161 acgcagatca ctgtattgtg gcattacaga attgtcatca gttagggacc gtatgttatt
    11221 tcttttgcgt gcatgcttgt tctcccgtaa agcctccagt tggagcaagc tatccaaccc
    11281 cagcttttgc tgcggataag ctggatacac gatggctgag gaagccgtag cttttacagc
    11341 aatcacgtca tcactaacca tctgataacc tgcctgccta aaagcagcag ccagtgtcga
    11401 tttgcccgta cccgattcac ccacaaatgc gtaggccctc cccccgatga cgaccgcact
    11461 tccgtgaata ggtaatattc gtctttgcat cagcagaaca cccatgcatg tacccagcac
    11521 aaacagccgc acggtgtcag gatcggcccc ggagaatatg cttacttcga tctccttgcc
    11581 ttccctgacg gcataaatgg ccgtgcctgg tatttggaac ataaatcgct catctagcat
    11641 cacaaaattg gcctgctcca gctgaccact ccatgcagtt aaatcagcct gccgaatgac
    11701 tacatcctct actgcttccg gtgctgccag gatcagctca ggcagattca gctcactggc
    11761 aattctgagt ccaaaggcta tatatttcgt ccaactgaca tttgcactcc tgtcatgcac
    11821 gataggactc actcctctgt ccttaaaaat cccgtcttta tttcttgggc aatacctcta
    11881 acccgaagaa ataaagacgg ctttgtattg aatacgagtc caatggatta tgctattctc
    11941 gttcattcag tcgttatcgg accagttttt tgcttccagc ccaacatcgg ctgcatgtat
    12001 aaccatgtgt tagcttggat tatgaagatc ggcatcgtgg tcagacaccc agtcaatctg
    12061 tttccagcct ttacccgcca tagtctggtt aatatccagc acctctatcg tcggttcctg
    12121 ccattctttt ttactcatct catcacctcc cctccaacga atggcgaact gtctgaccgg
    12181 ataggttcga tcagttcaat ctacagagaa aacggtacac gatcaggcta tgcattagta
    12241 gtcgtatatt cggatcagac gcctgctcag ggcgggggtg gtgaagtttc gccatagccg
    12301 tcttaataaa ctcaatattg agatattcgg cggctcgtaa atcatgacac atcagttgaa
    12361 gctctcccat aaacgtatcc cagcaaggaa gcattcgatg tagccaatct gcaggctgta
    12421 caccgcgtac ccgctggttc aaccgaacat catcaggtag atgatcacgc atggccgtac
    12481 gaatgagggc acggtcccga ccgttttgca catactgttc aaaaggcacc gataagcaaa
    12541 agcgaatcac tcggctgtct ccggtcggat cacgttccca caggccatac cgtagtgaaa
    12601 gtttggtcgc gaccacacca tttttgttag caatcgccaa attcgaaaat ttctcttttc
    12661 tcgtctgatc ggcgtttttc atccagcctg ttccgctcaa tacaggaata tcttctacat
    12721 gcatccgttt ggcaaactcc gggtgaatca gtgaaggaac gggacttcga ttgctacgcc
    12781 gcagccatga acgagattca agcgaagtcg cctttttcaa catcacaggg agtagatgag
    12841 acatacgcct gcccgtaagc ttgctgtacc gccacaatcc ctgaaaggat tgcaaccagt
    12901 gcaaacgacg aaactgccgg gcataatagt ctagtgcagg gccccatgat acggtaaaat
    12961 tgcctcgtgc cccggttaat agtacaccga cattgtgctc ctgtgctttt tcataaaaac
    13021 ctctgatcca gaaggagttt tcaaaatatt tgtagggtgc ttccatgagt tccagccaaa
    13081 tatcaatttc agaaaacgga cttttcccct caaaatccat ataattttcg tgaatgttgc
    13141 ctacatagcg agccgtagac tgaatatagc ttcgttcgtt cgccagcaat gtaggcggtg
    13201 tccagtctgt aaaatcttga acaggcacat agctgtatgc atgcagcggc ttttgttgca
    13261 ggtgcagcga tggcgcggca aagctggcaa ccgccccgga atccagccct ccgctcaagg
    13321 cagcccctac agcacgatgc gtccgtagtc gggcagtgac cgcctgtgtg aacacctcgc
    13381 ggaaagcttc tatgtactcg ccccctgttt tgagccgcag tggctctacc tcatccagac
    13441 atgcatattt atgaagggtt cgcttcccct cctccatagt gaaccaatgt gcaggaggaa
    13501 gctggttgat atgcttgtat gcagtcgttc cgatatcgac ggattcctgc atggcacgga
    13561 tggacaaaaa ttcggccagc cacggttcat gcagttcttt tcgcagagag gacagggcca
    13621 aaagtggagc gactaccgtg ctaaacgcga atcctcggtc atgttggtag atgtacagcg
    13681 tacgatttcc tgtcatatct cgagcaccat ataatcgatg ttccttggca tcccaaatga
    13741 caaaggcaaa atcacctatc agataactgg ctgcttccac tccccatttg tcatatgcca
    13801 gcaaaatcag ctcgctgtcc gtgatatctt gccgccgttc ctgctcaact cccagccgtt
    13861 caaacagctc ggaacgattg tcaataatcg catccgccgt gattgccaaa tctcttagct
    13921 catcatagaa gggaagacgc tcatgaacag attccggggt cacatgctgg gcatgacaac
    13981 ccaaaaatat tgagccttcg caccaagcgc atacgcggtc agcgggatat tttcgcaggg
    14041 cttgcatcat tttcccgcct tcttcggtgc ttacggactc atgtccaaag ctatagattc
    14101 cggcaatcgc actcacgttc ttcccccttt ttcttttcct atgcttgata acgctacaga
    14161 cgccaagcgc ccgagcttac gggcaaagag gctgcgagat cggagacctt gatttgggcg
    14221 ttgatagctt tggagctgag cgataagacg gttccgctcc tcatagctat gtgccaacct
    14281 gttttccagt gattggatcc gccgatcgtt cacgatctgg tccacctcca tccttgccag
    14341 atcttgaggt acagtatgac gggttgcatt tatcacaagt tctctgttat ctgcatcccg
    14401 gtcttccagc atccgataag ctgccttcca ttcaaagccg ctttgttgga gaaattgttg
    14461 tgtacgttga ctcagcagct ctatatccgg ctcatcttca aagcggactc cagtcatctg
    14521 ctcagcctgc tccaacgctt ccgcgtaccc aagctgccta aacatgcggg acccaatgct
    14581 tctgcaatac agctcaattt ccgttttact caacaaatgt tgccagctat gtaccgaatc
    14641 ctgatgcgcc tgctcatgct ctcctacgaa tggatcaccc gctcccatac tataaaaaag
    14701 actggatttg ggcgtatccg caaagtctcc gtacttttcc atccccggct catacttgat
    14761 ccccagaaaa ctgcacagct tctcgatctc catcgttgga ttggatacga gttgttcata
    14821 cctaagcggg tatgcaagtg gatgaggtgt agcaaaataa tgagcataac ggaacaaacc
    14881 aaccgtaata tccgtcattt tcatattaaa atgcggactc cccagttcct ccagcagttg
    14941 aaaacgtcca ttccgtagct gattgacctt tttgaatgag gccacaatgg ctaaaggatt
    15001 ccggataagc cacagcctgc gggcatcagg gaataaacgg tctataaatt ccagcaccgt
    15061 atagtaacgc ggggatttgt cgataagcat atctgctgta gttccttgaa gcagaccatt
    15121 atatatttca agtgcatacg aacgggaggc ctgctccaat acgtcggagg gaaccatacc
    15181 tttaaaaaat tgccgaagta tccctgttcc tccatatggc cgtacatgtg actgaggaag
    15241 atcatataaa ctgagcagaa accacatttc ctgtgtggca aacaggcggg aatggttttg
    15301 caaaatggcg gtaagcaacg agcttccact ccgagggaca cttaacagga ataccagccc
    15361 tccgccttgc ttttcaatca agcaaactcc tcctctacct ctgctcaaga cactttaata
    15421 gatacatatc gtatttttat tataaattta tgatacataa tgtatcttgt caatcccttt
    15481 gatggataaa ttcagcactt cacgttcatg ttaaaccata tgtagatcta taagctcaac
    15541 aatcagcctg taaataaaga ttttgctgca tgttagccca aggaggatag cactatggga
    15601 caagctgtta aaggtactat taccattgaa ggtcaggaaa ttcctatcac caacccggat
    15661 aaaccactgt ggcctgaagc aggcgtgact aaggcgctat atcttcgcaa gctcgcggta
    15721 ttggctccct tcctgctcaa atattgccat catcgtctgc tgaccgtcat ccgctggcca
    15781 catgggattc acggtgattt tttttatcag aaaaatgccc cacgtcctcg gccggactat
    15841 attgaaaccg ctctgcatga tggtattgaa tatatcgtgc tcggcaaatt gccacaactt
    15901 ctctggcttg gtaatcaagc tgcgttggaa ttccacccct ctctgcatga agcgggaagc
    15961 aagctgccct gtgaatggat gattgacctt gatccatcca gagaggtgga gccacgtatt
    16021 atggaggcag cctctattgt cggtgaagta ctggcttcgc ttggtttgga ttccgtcccc
    16081 aaaacttccg gggccacagg tgtacaaatt atcgttccga tccgtacagg cataaccttc
    16141 gacgaacttc gcagcatcgg gctattagtt ggacagtttg tgacagaaaa gcacccgcat
    16201 ctgttcacac tcgaacggtt aaagaaggat cggggaacag ccatctattt tgattatttg
    16261 cagcattatc aggggaaaac tctggccgct ccttataccc cgcgggcacg ccccggcgct
    16321 acggtctcca ctccgctaac atgggaagag gtacggcaag atgtatcacc acttgactac
    16381 catttgctga atattgaaga acgactaaac caggtaggtg acttgatcga caaggttcct
    16441 ccccagcccg tagaagacgt cctcaagcat atgcgcacca aggcacaccg aacctgatcc
    16501 atgcttggaa gaacaaaaaa ggggacgaac cccgcagcca ttaggctgag aaattgtccc
    16561 cttgcgctag tgtattcctt ttttcttaaa gcgtccgccc ttcacatcgt gaatgttacc
    16621 gatcgcaacg aaagcgtgtg ggtcccaatc ttcaacgatg ctcttcagct tcgcttcctc
    16681 cagtcgggta atgacgacga aaatcacttt cttgctttcg cccgtaaagc cgccttcacc
    16741 ttccagataa gttacgcccc gtccaagacg gtctgtcagg gcatccccaa tatcacggta
    16801 tttttcacta ataatccaga ccgatttgga ctgatccaga ccctcaattg taatatcaat
    16861 cattttcatg gcgatataat aagcaatcat ggaatacagg gcattcggcc aaccgaacac
    16921 aaaacctgca cttcccagaa tgaagatatt aacgaacagt acgatctcac cgaccgaaaa
    16981 aggagttttt tcactgacga gaatagctac gatctctgtt ccatccagcg agccgccgga
    17041 ccgaatcaca agacccaccc caacgccgag aatgacgccc ccaaagatag cacccaatag
    17101 tggttcgcca ggagtcaatg cacttacatt gtgaagtaac gcggtaccga tggacatcac
    17161 gataatgccg aataatgtgg ataaagcgaa ggttttaccg atttgtttgt atccgataag
    17221 taaaaatgga aggttcaaca gggtcaggaa aataccgagt ggatagccag taatcttgga
    17281 ggccataatg gaaatacctg tgacgcctcc gtcgataacg ccgttaggaa ccagaaatat
    17341 ttcgaggccc actgccataa gcgtcgcacc aaaaataatc atggccgcac gctgaaacag
    17401 gcgttttgct ttgttcttcg gattagctgg aattttgctg atcttggtca actctccggt
    17461 tacatctgtg atttcagaca gattttgaac ttccttgctc actacactca tatataaatc
    17521 cccccgttac agtatggtat attggaccga aaaaggggct gctatccgca gtcccctctc
    17581 ctttaccgcg cttgtgttat atgaatagta taccataaaa ctgtgatttt gcgcaaaaaa
    17641 gttagcaaag agcacataaa tcacaataaa gcgggattat atcgataaaa acggcgaaaa
    17701 ccgcctttaa aggagtggag agagcatgcg agttagaatt tcagctattt tctgagatcg
    17761 aggccgtctg cggaacacgt ttaaatctat gcgtgaggag ttggaaatgt cctctacaaa
    17821 atcttccgaa agccgttcca gtgctgaatt agcaaaaact atagcggtca actcaaaatt
    17881 atagaaaaag ctgcgcatgt ccatattggc ggtcccgacc gagccgagta aatcatcgac
    17941 aatcaccact ttggcgtgaa taaatccttt tcgatattgg tagaactcca cccctgcctc
    18001 cagcaattct tgcacatagg ataaagacgc cagatgaacc agcttcgaat cggattggta
    18061 gggaataata attttcacat ctacgccact gactgctgct agcttgagcg cctcataaat
    18121 ccccagatcg ggaataaaat acggcgtcgt aatccaaatc cgctttttgg caactgtgag
    18181 cgctccaaaa cacatttcct gaatcgtatc ccaaacctga tcgggaccgc tgctcaaaat
    18241 ctgtacttcc tcatccccag tgcaggtatg tggaggaaat aaattcacat ccatcagcct
    18301 ttcccctgag gccagcttcc agtcgctaag aaatgcattt tgcagaaaat agacgctatc
    18361 tccttcaatc tgcaagtgcg tatccctcca aaatcccact ttggggtatt ttccgagata
    18421 atcgtcgcct acattaatcc cccccacaaa tccgatcatg ccgtccacta ccacgatttt
    18481 cctgtgattg cgatagttaa tccggcggtc caacgtggcg aaaaacggag gtagaaaata
    18541 atgaaattcc actcctgcct cactacaggt acgaataaag gaatagggca aatggtagct
    18601 tcctacaccg tccacaacga atcgtacctt tactccctca cgtgccttgc ggatcatgac
    18661 ctcttgaaac tttcttccga tttcgtcggc acgaaatatg taaaactcca catggatatg
    18721 atgttgtgca tgttccatcg ctgtcagcat agcctcgaag gtttcttcac cgttcgtcag
    18781 cacacgtgtg cgattacatc cagtcaacgg gttttccgac atacgaatta actggttaaa
    18841 cagtcgctcc tgatgcttga aatgaggatt atgcatttgc tccacatgtt caatcacttt
    18901 ggattgcgcc cacagacgct cgcgaaactc acgaaacagc tgcgatcccc cttttcgaac
    18961 cattttgcgc ttctgataat cctgtgcaac aaagtagtac acgacaaagc caatgagcgg
    19021 gaagcaaaac aaaataaaaa gccaggctac cgctttggac ggcttgcgaa attcaaagag
    19081 caggatcgtc ccggtctgaa aaataaaaac aattaaaacc aacagcaacc acagcatgtc
    19141 taagcctcct tatatatctc aggattttgc aaaatcctca tctacgtttt atactaagct
    19201 ccaatttttt tgacatgttt gcctcttaag ctgaatagat agtaaccaag cactatagga
    19261 gcgatgtccg gaaaggagcg attatgaaaa aaggaagcct aaatcgccgg atgaccctgc
    19321 ttgttattcg ggatgcacag caaccgccca agcagctaca atgctctaca gccgctgtca
    19381 ttctcgtccc aactcttgtg atcgcgtcta tctctacact cgtgatcggg ctgcaaatcc
    19441 attcttccca tattatctcc caaatggaaa cgaatcttgc tgtccagagt ttgcagatgg
    19501 aggtcacggt agcggacaag gatgcagcca ttgggcgact acggcaggaa gtcatggagc
    19561 tgacgaatca agccaccaat attcgtgaac gcctccagcg tgtaacggag ctggaacagc
    19621 aaatgcagca attcattcgt aaacacggaa actcatctgc cacaagtaac cataaaaaga
    19681 ccatgactcc gctctcctgg gatgcttccg gccatatcgg gggcgagctg atcgcagtgc
    19741 atgaaaatac tgccctccta actcgccagg caatggatga ttttcaggag atcgaatctc
    19801 tgttggacac ggtggaacgt acggttcccc gctctattca gcaagcaaat gccgtacagc
    19861 agaatctgga gcgcaaacaa gccgcacagc tactccagac tcgtagactt gctcttgccg
    19921 agcaagggaa tccctccgtt tggcctgtag gttcacggcg aatgacctcc agcttcggct
    19981 atcgcagcga cccttttaca ggcagatctg ccttccattc aggcgtggac attgccggac
    20041 aaaccggtga tcctgtctat gcagcaggag ctggcaccgt cttggaggct gcttctagcg
    20101 gagcccgcgg caagtgcatc atcatccagc atcctgacgg actccagagc tggtatatgc
    20161 acctgagcgg catgcaggtg gctccggggg atcgtgtcca caaaggacag accatcggtc
    20221 tgctgggaag taccgggaga agcacaggac ctcatcttca ttttcagatc gtcaagcata
    20281 accaacctgt cgatccatta ctgtatgtac aatgaggatt tttgaaaata tttacaataa
    20341 aagattgggg gaaaaccatc atgttcaagg aatccaaaaa aaagctctcc gccccagcta
    20401 tggatacact gctcgctaat ggcaccagct ttgaaggtac agttgaggca gaggccaata
    20461 ttcggattga cggtcatttt cagggcgata tccgcagcac tcgtactgtc gtcattggag
    20521 aatctgctgt tgtacgttcg gatatcatcg cacaagacgt cattcttgcc ggtaaggtgt
    20581 ttggcagcat tactacagaa ggacgactga ccattacgcc gacaggtgaa ctgtacggaa
    20641 ataccgcgac cactgcattg gtcatttctg aaggcggtat actggacggc acaattcaaa
    20701 tgaaccgaac aaaggatgta gagttgtcaa cttctacgga tgagtcaaac gacgaaaccc
    20761 aatctagttt cagcaaaaac aaggaggata gccaagccgc tctgcaatcc gaagcaggat
    20821 aaagtcagta tatactcctt taaatccagt gcattctcca ttcattccat aatatcctcc
    20881 actctgcgtt ccaaaaataa ttggtacacc ttgcgtatga cgatttttcc gcacatatac
    20941 aatggaatca ccaaaatgat acccagaatc ccgagcaggt cgccaccaac taacagtaaa
    21001 ataacgacag tcaacggatg aatatccagc tgcttgccaa aaactatagg tgacagccaa
    21061 ttatcctgaa tttgctgtgc agcgatcacc acgaccaggg accagagtgc catcgaaggt
    21121 gattcgagta atccaataat aaccacaggt atagaagcag ccactgcccc cacataggga
    21181 ataaaattaa gaaaaatcga aataacggca agcagcaagg cataaggcaa gccaataatt
    21241 aaaaatccaa gaaacatcat cacacccaac gcgacattaa tcagcacccg actcacgata
    21301 aagctgctga gtgcactatc gatatcttcc ataacctcca atgcgtcctt gtgatatttt
    21361 tttggaaaga agtttagcat tttagggcca aacttgctcc cttccttcag catgtaatag
    21421 agcaatattg gaaaggtagc caatacaata aaaaagtagg acacgaacga taccagcttt
    21481 accgaataat cagacagtgt cgaaaaagct tcgttcaacg tatctgacag ttgtgacagc
    21541 gggtcttcac ccggaggcag cacttgtctc aaggattgat tatgccgcca ttggctcaat
    21601 tgatcaacca gacttttaat gagcttcggc gcattttcaa ataaattggt aacttgatca
    21661 cgcagcgtag gccacacacc ccatgagaaa acaaacaata acactccaat gaccaaataa
    21721 atcagcaaga tggagataga tcgtttgatt tttctccgtt ccattacatc tacaatcggc
    21781 ctcaataaat aatagaggaa aaaagatagc atcaacggta caaccagcaa gctgaccaaa
    21841 gatacgagag gactgaatat aaagcttact ttggtgccca agtaaatgat gagtaatagc
    21901 atgacaatac ccgtagtcag acgaaaaaaa cgattatttt gcagcatatc atgcggcccc
    21961 cctctattct gtttctctct acctctttaa acgcaaaatg accctattga ttgattcttg
    22021 ctgaaaatag attacaatat acccctgcac gcagaatgtg tagtaaaaat gacatagata
    22081 caggataaaa tagtcttaaa tgaggatttt gcaaattcct gaaataacaa aaggacgtcc
    22141 aaatgctagg catttgaacg tcctttgtgt tactctatgg cacttcgatt taggtcgaaa
    22201 catcccgttt tacgaaaacc acccaggcaa tggcgataaa aatcacataa taagcggcca
    22261 gcacggtgag cgaaaaggtt agactggaac ttaccgtacc cggcggcata tctaaatatt
    22321 ttttcagatc catatgcgta aatagaacgt atttggtcca ttcaaaacga tctgtgctga
    22381 acaaaccaat cgtgttataa actgttttgg tgaacatcat gaacagtgac agcccaatcg
    22441 ccaaggcact ggaacggaaa acagcggaca gcataaaagc aaaggccatc gtcacgaata
    22501 aggcgatata gctatacaaa aagttcagcg ttacataaga tatcggatca ctgaacagtg
    22561 gaacagaacc cgctggtgca tccttggaca acatcagcca tgaggacagc gtaaccatca
    22621 agatcaaaat gatcgttccg agcaaactga acaaaatcac ggataaatac ttggacaaca
    22681 atattttgct gcgagtccaa ggtcggatga gcagcagctt aatcgttccc caagtaaatt
    22741 caccagccac cgaatcagcg gctacaatga ccgtaaacgt cgtattgagg aaaaatgtaa
    22801 acaacgtcgt caacgcaatc ccatcccaca cactgacctg atcggaaacc agggaaatca
    22861 gcatcggaat cacagcagtg atgaccgcca gcaatcccag cataatccat gtgcgcacac
    22921 gcaggtaaat tttcagattt tcgttatgta ccagcttgaa gaaatcaccc aatgaccccg
    22981 cctcccgtca cttccaaaaa ttgatcttcc agcgtacggg caaccgggcg aatcgcatat
    23041 actttaatgc catttgcagc cagcaggctg ttcatctctg caatctgttc ccgctccagg
    23101 tgaagcagca gttgattacc ttcgacgcgc cctgctccag caagcgcata agcttgttcg
    23161 gcatcattta cctcaaaagc aatttccgcc ttctgcactt cctcccctgt attcttcagt
    23221 tgcttgatat caaccagccg tccgctctga ataatagcta cacggtcgca catcagctcc
    23281 atctcggaca acaaatggct tgatacgaat acagtaattc cttccgtacg ggtcaattga
    23341 cgcaaataat cccgcagttc acgaataccc tgcgggtcca agccattggt cggctcgtcc
    23401 agcacaagca gcttcggtcg atgcaaaatc gcctgagcta ccccaagtcg ctgccgcatc
    23461 ccgagcgagt aggtttttac tttatcgtga atccgatttc cgagtcccac cagacgaatc
    23521 gcttcttcca cgcgctcttg ggtcacccca ggagacattc gcgcaaaatg ctgcaaattt
    23581 tgatagcctg tcaaaaactt gtacatctcc gggttctcaa caatcgcgcc gacatgggca
    23641 acggcctttt caaaatcggt attaatgctg tctccacaaa tatgaatatc gcccttgctg
    23701 atcgaaatca ggccaaccat catacggatg gtggtcgttt ttcccgcacc attgggtcca
    23761 aggaaaccaa atacctgccc cgccggaacc tccagcgtca gatcatccac gatcgctttt
    23821 gaggaaatga ttttactcac accctccata cgtatgacgg gaacctgtcc tgtcgcttgc
    23881 tgcatgcttt gaaactcctt ccatccggag tgaagctgtg atccatttta ctgtacattt
    23941 ccggttttgg aagtattgta ccatatttaa ccttttagaa acaccacgca acctctattc
    24001 cttgtccttg tatatccaaa gcacccgcca cttctcatct tcctgcgtca cataacaagg
    24061 ctgtacgata tcaaaattac cgaatcgggt cttgtaatgc tgagtgactg taatac
//
