LOCUS       NZ_CP109848            27007 bp    DNA     circular CON 22-NOV-2023
DEFINITION  Paenibacillus polymyxa strain K16 chromosome.
ACCESSION   NZ_CP109848
VERSION     NZ_CP109848.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5978518)
  AUTHORS   Manfredini,A., Vitali,F., Sas,L., Trzcinski,P. and Canfora,L.
  TITLE     Genome sequence of the Paenibacillus polymyxa K16 strain isolated
            from soil of tomato roots
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5978518)
  AUTHORS   Manfredini,A., Vitali,F., Sas,L., Trzcinski,P. and Canfora,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-OCT-2022) Research Centre for Agriculture and
            Environment, CREA - Council for Agricultural Research and Analysis
            of the Agricultural Economy, Via della Navicella 2/4, Rome 00184,
            Italy
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2022
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 270.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 06:01:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,334
            CDSs (total)                      :: 5,275
            Genes (coding)                    :: 5,199
            CDSs (with protein)               :: 5,199
            Genes (RNA)                       :: 59
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 52
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 33 of 76
            Pseudo Genes (incomplete)         :: 52 of 76
            Pseudo Genes (internal stop)      :: 19 of 76
            Pseudo Genes (multiple problems)  :: 22 of 76
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:36:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5041740
            Orig. end                         :: 5068747
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP109848.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Strain stored in SYMBIOBANK
            culture collection of the National Institute of Horticultural
            Research in Skierniewice (PL).
FEATURES             Location/Qualifiers
     region          1..27007
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27007
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27007
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17007]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17007
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(1303..2001)
                     /locus_tag="OF859_RS22590"
     CDS             complement(1303..2001)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-161). E-value: 1.3e-11. Score:
                     36.4. Matches aSDomain:
                     nrpspksdomains_OF859_RS22590_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426685.1"
                     /locus_tag="OF859_RS22590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_264453982.1"
                     /transl_table=11
                     /translation="MKIYAIDTSKPEAEEHYELLVNRVSLEKQHKLDRFLHREDALRGL
                     YADVLLRWLVCRQLKVSNASLQFTYNAFGKPSLINAPAFHFNVSHSGKWVVCAIDDYPL
                     GIDIEQLRPIDFEVGRVCFSDTEYDALMRQDADNRLSYFYDLWTLKESFVKAEGQGLTL
                     PLKSFSFELKAQPFIGFTTKGFTTEYCHFKQYELDQDYKMAVCAAHDQFAQQVQQIDIN
                     TLRLEVATQA"
     aSDomain        complement(1519..1692)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_OF859_RS22590_ACPS.1"
                     /evalue="1.30E-11"
                     /label="OF859_RS22590_ACPS.1"
                     /locus_tag="OF859_RS22590"
                     /protein_end="161"
                     /protein_start="103"
                     /score="36.4"
                     /tool="antismash"
                     /translation="LGIDIEQLRPIDFEVGRVCFSDTEYDALMRQDADNRLSYFYDLWT
                     LKESFVKAEGQGL"
     gene            2229..3695
                     /locus_tag="OF859_RS22595"
     CDS             2229..3695
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686791.1"
                     /locus_tag="OF859_RS22595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_264453984.1"
                     /transl_table=11
                     /translation="MKYDFARLLCIMLSILLTLSIFQMFSPKIASAASANVVNGIQFKD
                     TDGNVVHAHGGGMIKVDGYYYWFGENRNPNGTFKAVSAYRSSDLKNWEFRKNVLTSSSA
                     VELNVSNIERPKVIYNEKTRKYVLWMHKENGVNYNEARVAIASSDTVDGDYTYQGSFRP
                     LDHDSRDMTVYNDNGTAYLISATRVNADLNIYRLTPDFLQVESLVTTLWPGQYREAPAM
                     FKKGDVYFLITSGATGWNPNQAKYATASSIEGTWSNTINFGDGTTYGSQSAYVIPVEGA
                     QTTSYLYLGDRWAGAWSGPVQDSQYVWLPLRFPTATSLAMDWFDSINIDTASGAVEGIT
                     TPIAIDPDAYYQLVNRKSNKPLSIIGNATTDGADLEQRANSGAANQQWQLKDAGSGYYK
                     IVNRNSGKLIGVESGTTTDGTVIEQWSDGGWSSQHWQLVSVTGGYYKLKNRATGKLIDI
                     SEGATADGAKAIQWGDNGGTNQHFRVVKVE"
     gene            complement(3805..4320)
                     /locus_tag="OF859_RS22600"
     CDS             complement(3805..4320)
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - acyl-CoA hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280639.1"
                     /locus_tag="OF859_RS22600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_013309488.1"
                     /transl_table=11
                     /translation="MESKYIRETYCFKTSRVFPNDINNHNTLFGGRLMSYIDDIASIAA
                     AKLCRTNTVTASTDSVDFLLPIHPSDSVTLEAFVTWTGRSSMEVFVKVIREGLMTGDRK
                     IAATAFLTFVALDENNRKVTVPQVIPETEEQLQLHQTAPSRAAIRRQRREESKQLASFL
                     TTDYPWEL"
     gene            complement(4421..4969)
                     /locus_tag="OF859_RS22605"
     CDS             complement(4421..4969)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429618.1"
                     /locus_tag="OF859_RS22605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_264453986.1"
                     /transl_table=11
                     /translation="MDSMQHIIGSNLAQIRKIRGLSLDKVAELTGVSKGMLAQIEKGKS
                     NPTVTTLWKIANGLHVSFSTFLKEDPPQITKIRREDLHPVIDEDGNYFVYPVFPYHAEK
                     KFEVFTVSLKPGFTHQAEKHLGEETILMIRGEMYFEMQGQQLKLSAGDAVQFQVSDIHT
                     YRNDSDEDADFYVLIYYAD"
     gene            5383..6621
                     /locus_tag="OF859_RS22610"
     CDS             5383..6621
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426681.1"
                     /locus_tag="OF859_RS22610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_264453987.1"
                     /transl_table=11
                     /translation="MNLQTRKSRHMYTMQLATIFIGFIVFGISENIKGPAIPRIQFDFN
                     LDEQQLGTLLSLNALGYLIACSFTAVLVRKWGIKAVSIISFASMIISGVFIYLSHTYPF
                     FASSYFLMYIGNGMLEIALAILGARIFVKNTGTMMNLSHFFYGLSSTVAPLLATGVMSL
                     TVFGHMLDWRGMYLAMLSLCLLPIVAALLSTFPGDDLQHEDRTSLKTLTCDPALWMMVM
                     ILSFGVVSELAVGGWLVNFLEKAYSWNTVKASSMLSAFFLTFSLGRLLLGPLTDRMGFV
                     LSTILFSAFSAICTFAAIAGGERLAFLFAVSGAGIAMIYPTVMAFIARRYPKDSDTAIT
                     FVVTLMGIGSVIGNYVIGWVIEGVKIVYGATTELGILRGLQAGYGVIGLCAAICAISGI
                     ILYGYLKKRQELI"
     gene            complement(6695..6868)
                     /locus_tag="OF859_RS22615"
     CDS             complement(6695..6868)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OF859_RS22615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_155766935.1"
                     /transl_table=11
                     /translation="MYLPKRFGRVPVPDDLAAASHPKAVFKCTPDELFEMANGQELMMN
                     QSSSDVFIQGLF"
     misc_feature    complement(6990..7003)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     gene            7023..7748
                     /locus_tag="OF859_RS22620"
     CDS             7023..7748
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="OF859_RS22620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_023987840.1"
                     /transl_table=11
                     /translation="MSIASELSGTKHDSLSFLQGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIAFMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLWKNIGIGVLLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIASCVAGGVLG
                     NWISRPEAFGLDFALPAMFLALLISQLQSVQTSKLKHRLLLVLCMAVLMYLLAWWVPSH
                     IAVIIATMITATIGVLTDK"
     gene            7745..8068
                     /locus_tag="OF859_RS22625"
     CDS             7745..8068
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003331885.1"
                     /locus_tag="OF859_RS22625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_023987839.1"
                     /transl_table=11
                     /translation="MNINPNVLYIIIGAMIVTAIPRIIPFVVLQRLALPKPVLQWLSYI
                     PICIFTALVMENLLVRTETSVTLNGQVLMAVLPTLVTALWSKNLLATVVVGIVSMAVIR
                     LLW"
     gene            complement(8113..9738)
                     /locus_tag="OF859_RS22630"
     CDS             complement(8113..9738)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="OF859_RS22630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_237449031.1"
                     /transl_table=11
                     /translation="MLYDLINIGESFFRKMFQSRLSNQVNIRIIEKAQKMSLQSFEDAD
                     VQNMLQRAQGEADFRPFEIFTQILAIISSVVTLFSTGAILIAWRWWAFLFIFLIPCLSF
                     YSFLRIGQREFNVHFQRAGRQRESWYLSFLVTRDNSFKEVKIFQLGDYLRKRYKTILEG
                     FYREDKVLAVRRSYTSLVFQIVNQGACAFIIFMAIQATYVGQILVGNLVSLIQGITLTQ
                     STSQSIVQGILSLCQNNLYIKQLFDFLDMPEEAKIQKTVQQLPLSTIHSIEFRNVSFRY
                     PNTEENAISNVSFKLHQGEKLAIVGRNGSGKSTIVKLLTHLYSDFEGEILINGHSIHEL
                     DKDSFREKIGVVFQDFVHYEMAVRDNIGFGNVASRENDEAIWTAIDKAGITDLIVGLPD
                     KMNTLLGKWFEDGQQLSGGQWQRIAIARAFMRNADIYVLDEPSSFLDPHAEKEVFQKFD
                     QLIHEKIGVFISHRLSSARMADTIILMEEGKIVEAGSHEHLMDIDGVYAEMFRLQASSY
                     LSQRERGFEEGDLSPSLVRTTGGA"
     misc_feature    9692..9705
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    9740..9753
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 22.3"
                     /tool="antismash"
     gene            complement(10001..13120)
                     /locus_tag="OF859_RS22635"
     CDS             complement(10001..13120)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370171.1"
                     /locus_tag="OF859_RS22635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_264454845.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4e-190, bitscore:
                     631.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.3e-15,
                     bitscore: 54.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.5e-53, bitscore:
                     179.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSDQDVDSQLTLEEITLRLKLISQEAVVQEAISLASPSLMQFLH
                     YLNDGHALDDKGELQKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICGKTTDLDIGS
                     YPKHLKRARPDMEWIYKLIQKIEADPAIFNQLKVFLNKTVMIKGNRAKLPFRPKHGAAE
                     ADDSAEIFNSIRLTDVVRMTFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQ
                     EFILSELRPPLMDHSPFHYIFEKIKKLDISDPWIHILHEIDTLLLQYNQCTIGEGEKVY
                     RKLCDKMLDIISVKTPVQVDVLLDKEVTLPKHVLDEVSLGAEVMCKLYASPKTDELAEY
                     LNRFLEKYGVYQEVPIHELFDEDWGLGIPEMYRSNEKKSMGMEAFKRNAVLFQWVSNAI
                     SNHEIELALTDEQLEQLMISDNYDTSPESMEIYYSIFAESPEKVDSGDYSLLLGASAGS
                     NRAGKTFGRFLDMFSEEFVQKFSEIYDHHRCFHPDALLSEMVFMPEQGKISNISLSKNL
                     MAYEIVSGTTSSKDEDHTLCIDDLVVGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPH
                     IFRFLTDITNKEIGTWSYFDWGPLEQSPFLPRLVYKKIIISAAQWKLSKASLNISESCE
                     SKEGEELFHVWRQQWNVPRYVYLTMGDNRLLLDLCNLFHIKELLHEVSKTREGQELLLT
                     ECLGNPFHTPVQGTAGRYMGEFVFPLKKKKIKVKPSIPSSQNHIVSQNFITHTPSSIHR
                     GIFPGGEWLYLKLYGVKERETDLVGLSLGHLLKQPGFKDWSRKFYFLRYVDPEHHIRLR
                     FQGEPDKLWTAGLAQLNQWAAELREEGLITNMVIDTYHPELERYGGQTLMELAEQVFDV
                     DSQWVIAYMKGIRSNAFNLDIEIAAVINIIHYLSGFGLTIQEQVKWLEERIDCKPHMKA
                     FRDVKKTLITAVESNYEWIGQADTNTQVAFLALVEKRQTMIQQYAQAIILAKNNHELTN
                     PSDDILGSIIHMHLNRLLGVNREREIKCMALAKHTVANLLHRKGVSYVTV"
     aSDomain        complement(12425..12709)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_OF859_RS22635_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-17"
                     /identifier="RREFam001.1"
                     /label="OF859_RS22635"
                     /locus_tag="OF859_RS22635"
                     /protein_end="232"
                     /protein_start="137"
                     /score="54.8"
                     /tool="antismash"
                     /translation="VFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRLTDVVRM
                     TFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSELRPP"
     gene            complement(13230..13907)
                     /locus_tag="OF859_RS22640"
     CDS             complement(13230..13907)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="OF859_RS22640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_264453990.1"
                     /transl_table=11
                     /translation="MKQKFMVISSFRKIKHFFETLSTPENIRIMFYDSLYQAIPEIDEQ
                     CIGVALNQDHITLEDLSYWHSIKEKFKVPFIFLSYHSDDQRQLDILKQLFSMASSKYGM
                     EREQQAISLSPNVIFDPAGKVIWKQGHEHMLTMMEFRLLMYLLTAKECASTIDHIIDRV
                     WGVDAFTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYKLNIFPKNLEVVSCEETT
                     ALH"
     gene            complement(13958..15220)
                     /locus_tag="OF859_RS22645"
     CDS             complement(13958..15220)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="OF859_RS22645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_264453992.1"
                     /sec_met_domain="LANC_like (E-value: 6.4e-59, bitscore:
                     197.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEDLKGRSVEISKYIAQKLIDLSYTEKIVNHTNNLSPSRGKSPW
                     NPGSLADGIPGVFVLLSEWGYLEPDQNWAEHVHSQLRYLDANSLLLLPRISLYYGTTGV
                     AYGILLASNNRANYNKLISQLNKYIEVKWGGLPVIGTIKEFSRQMDIINGLLGVGRYTL
                     EVAEDKTMCDLSRQLLDTITHFIPEYIHLSSRKDSTSIHLGLAHGITGILALLVTALQK
                     KIKVEGLHEAIKHIADFLLIQIQEDQYGWYWPVNSQASSMNKREKKVGMREIEGWCHGT
                     FGIAWTLFRAGIECSNEEWKKIAEKAMESIFCLDDELLNALSPTFCHGLAGLLHMAHRF
                     YSLTGNIAALHFADQIALKLVNLYDEELPFGYRDLEGTTHVHNVGILQGATGIALSLLD
                     YGIGKEHPKYSGRWSELFLIS"
     gene            complement(15297..15449)
                     /locus_tag="OF859_RS22650"
     CDS             complement(15297..15449)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="OF859_RS22650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_103048208.1"
                     /sec_met_domain="TIGR03731 (E-value: 8.6e-05, bitscore:
                     20.7, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKNEVAPKGVQPASGLICTPSCATGTLNCQVSLT
                     FCKTC"
     CDS_motif       complement(15378..15449)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKNEVAPKGVQPA"
                     /locus_tag="OF859_RS22650_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15297..15377)
                     /prepeptide="core"
                     /locus_tag="OF859_RS22650_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="5.90"
                     /molecular_weight="2508.0"
                     /monoisotopic_mass="2506.2"
                     /core_sequence="SGLICTPSCATGTLNCQVSLTFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKNEVAPKGVQPA"
                     /leader_location="[15377:15449](-)"
                     /alternative_weights="2526.0"
                     /alternative_weights="2544.0"
                     /alternative_weights="2562.0"
     gene            15646..17007
                     /locus_tag="OF859_RS22655"
     CDS             15646..17007
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="OF859_RS22655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_264453995.1"
                     /sec_met_domain="LANC_like (E-value: 9.9e-55, bitscore:
                     184.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDSFVIQQSDQVRARDISKKIALRLCEPESVYAAVHAEHNVSP
                     ETKYHPWGETSLSHGYPGNIHLLSQWRATDPSYDWNRAIHLNMAQIQSSLAKNGLHDLS
                     LYSGWAGIASSVREASNHGEYYSNFLQQIHQWMMPLTEQWLQSKTEQLSLHQGMPMQSF
                     DTISGASGIGRYILMNSTDPICTPLVEPILQFLTDLTHPIHIHNRYVPGWYSPQKFQFL
                     DRDKRNYPLGNFNCGMAHGIPGPLALLSVAYSAGIEVKGQYQAIETITEWLLKYKYEDE
                     YGSYWPHIVPFEAETGSLRFDLERAREAWCYGTPGIACTLFLAGKALHNEELQKLAVKA
                     CVGAISYEIAKREMDSSALCHGLAGLLTISWRMWCHSKEPAFLPLIQQLTNCLLDCFQM
                     DSPLGYLDPEPRADGSLVWLTKAGMLEGVAGIAAALLSVSENKEIGWDYILMLS"
     gene            complement(17008..17742)
                     /locus_tag="OF859_RS22660"
     CDS             complement(17008..17742)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="OF859_RS22660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_013309463.1"
                     /transl_table=11
                     /translation="MGSILRVETIKLQWIMVWILIILDAIINSLMGVLELNDLKQFFSP
                     SWLTLYTYSAQFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQQIYYAKYIL
                     LILILGLDQLIFIVGYFVSGNIAGAPGEIPWSVVLSTGLGGWLGIFPLAALQLMLSIKI
                     RNFGASLGMSICCVVPNIVITGFHSSIGAWFPFTIPYYIMMPQTATYAPRVEPYSLGLI
                     VIFTFLAYLYGGRKMFVNRDWL"
     gene            complement(17757..18464)
                     /locus_tag="OF859_RS22665"
     CDS             complement(17757..18464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="OF859_RS22665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_023987832.1"
                     /transl_table=11
                     /translation="MILRVIKAEGLKLKKICWWIPLIQGCVLTGMTAVEWYLYFRQGPG
                     GVYAGFAVMFMFLSFVMLLGGTLLASIMAGTEHDTQTWKQLMAMPVPRSYIYLSKIVWI
                     VILQLGTALITVAGMSLIWVLYTNEPIPWRIMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKILPWSYPALSSPLMKEHMIWVIVALSAGVIFT
                     GLGTLQFTKHEFK"
     gene            complement(18461..19384)
                     /locus_tag="OF859_RS22670"
     CDS             complement(18461..19384)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="OF859_RS22670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023987831.1"
                     /transl_table=11
                     /translation="MSEYVIHTQQLTRRFGKREFVKRINLQVPGQQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGEIEIFGKKLKDQRMEILKDIGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRRIHEVLDLVRLTKDAYRPVKGYSLGMRQRLGIAMALIANPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPGAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTA
                     KSKPQLFIETPDPVLAAGALIQHGWTAGAESIEQNEVVTPIVDRQQSSEMIKVLVEHNH
                     PIYRVTEKKKTLEEIFLELTGKERSL"
     misc_feature    19421..19439
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.67"
                     /tool="antismash"
     gene            complement(19529..20599)
                     /locus_tag="OF859_RS22675"
     CDS             complement(19529..20599)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="OF859_RS22675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_264453998.1"
                     /transl_table=11
                     /translation="MNSLVKMSFRFMKVTLCFVLAYVLCFVICTILYIFIKSIFGASQN
                     INIDLFWTGLGIVQSVVFIAAYGWYIGKPLVYVIKWIGNIATGEFQAPLSELELPEGKK
                     NQKNSYKPPYQLYKEVFEQMNILSAQLRSNEEERVAIEKRKQQWVAGVSHDLKTPLSYI
                     EGYAVMLTAQEYDWSDEERRSFSMGISEKVTEMKQLIQDLNASMQLKEGPLPIQLEKKD
                     IVEFLRSTVIDIANHPSAEQYEFSFTSMDAACIMPFDSKLLGRALQNFLINAIIHNPPG
                     THVSMEVSKANDKLHISIEDDGIGMNSNEYMQVSHSQGHGIPIAKSFIEAHNGTLHILS
                     GSKAGTRMEISLPLNI"
     gene            complement(20596..21315)
                     /locus_tag="OF859_RS22680"
     CDS             complement(20596..21315)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="OF859_RS22680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_264454000.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTTVLKKEGFLQVKHAATGREALQVVM
                     ESHVDVIVLDVMLPDNDGFEVCRQMRLYTDAPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVVARMKARMKYRKVSTVAMKPTLRTLDFGYFRLELESGVLYVEDKQVDCPARE
                     WLLLVFLCKHPNRIFSVRQLYEAIWSEAFLGDEKTVVIHISRLRKKIEPDPKHPQFLIN
                     VRGLGYKMMSVKMGEQE"
     gene            21480..22646
                     /gene="yhbH"
                     /locus_tag="OF859_RS22685"
     CDS             21480..22646
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="OF859_RS22685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sporulation protein YhbH"
                     /protein_id="WP_023987828.1"
                     /transl_table=11
                     /translation="MPEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPNLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGKPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSSYNIYPFHFSDGDNLTSDNERCVKLIEELIKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKKDQFMYYVIKEKGEVYQALRTFFRKREGGSVG"
     gene            22643..24085
                     /locus_tag="OF859_RS22690"
     CDS             22643..24085
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="OF859_RS22690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoVR family protein"
                     /protein_id="WP_264454001.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIADGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLEGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATADRINSYEVEYGSEAVESFIDSVLAIQEHVDP
                     QIIKPRHLDKQRYMELKIREQKEPGKRQRPPGPYDDLWSLETAKQHDPTETEGIKVRKF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGEETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKMFEVREFDSDTSFIRNYMTKKLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TLIEGKLALFSYDGKKHHRKFV"
     gene            24301..25332
                     /locus_tag="OF859_RS22695"
     CDS             24301..25332
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014649242.1"
                     /locus_tag="OF859_RS22695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_264454002.1"
                     /transl_table=11
                     /translation="MNTHPSFREVRESDQQVFPIAWYAVGWSKELKNKPLKKRLLGKDI
                     VLYRDDHRQVHAIHAYCPHRGADLSHGYCQNGHITCPYHAWSFDESGQCVDIPAHPGRA
                     IPEFAHTYAYPAIEKAGLLWVYPQAVGSKSEINSGLGTSTSPPPLEIFPELEDPSLILS
                     PYDSVWKAHLTRVVESVLDVAHLPIVHNKTIGKKSSTDIHIEFEADDNHIRVKNGKGLL
                     QYTFPQQWILTPAKEGRSKFINFVTFTPIEQELTAIYGLAGRNFARFVPGMGHIFSRYS
                     GKVLEEDRAVVESQHPRPIPEALRMEAHVPADGPQVRFRNRWYDFLVNDEPRVRLGPET
                     TSS"
     gene            complement(25319..26500)
                     /locus_tag="OF859_RS22700"
     CDS             complement(25319..26500)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820485.1"
                     /locus_tag="OF859_RS22700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_053325050.1"
                     /transl_table=11
                     /translation="MIKKNIGSYGQKNGSSHREDSRTRVFRQKATGVLMTGLIAGALFS
                     GCGMKSAGETNPASGMKPGQQLTVIDTDAAQQQVTDELVVSSIDRLGDVYARSWLSDEE
                     LIVERKTQLWIHNVETDKERILTPGRKAPQLLAVVSPDQRHVFFTEGSTSSKYDIQGYI
                     LELGSGKVTSIGKLDMTNEVSWSDENDLITGTPDGKIQLIGLDGKAKELSFQDPNRSEL
                     MSHVEKVGNAIFYTGSDKQGYPVLNRFTLNHPQAVTIAEGAMSFAVSPDGKSIAIEKRK
                     WNTSEPARMIILDEQGKEKGIVGQGTLMSRGSWSSDGSKLAYSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSPSARFLSMYQNISEGGKQLNQSYIVEFKRK"
ORIGIN
        1 ttccagcagc tttttccagg catataaata ttcagtccgt tctttcccca cccgatccag
       61 tacccaaggg aagtcacttg cgacaaaacg gggctggatg tccgcaatca gcggcagctt
      121 cgccattctc ttgaccaaat ccctcctaag cacctgtcca tggatcaggc gatctggcaa
      181 accgctttcc tccgtgagca catgggcctc catcgctgtc aaaatcatgt gcgctgcccc
      241 atcccctata gcatgtacag ccactggaaa gcctgcggcc ctggcagctg ccaccatctg
      301 attcagctct ggctgcggtt gaatcgccat tccgcgggta tgtggagcat cactataagg
      361 ttctgacaat aatgccgttc ttccaccaat agcgccatcg gcaaacattt taatcgcacc
      421 gattttaaac cactcatttc cggtacctgc acgcagccct tgcactttcg cttcttccat
      481 aaagggatga tagatgagct ggtgtgtgcg aaaagcaaga ccttcttccc tcagctccct
      541 gtaaattcgc tgcatcgtct ccacgctgcc caaaaaacgt aaatcttccg tgtgcgcagc
      601 agttagacca agccgtagcg catccaggca agcccgccga atcgtatcct tcttaaccga
      661 ataatccggc tctggctgca cgctagtaaa ggcaaaggat gcttcctcat aaatcaatcc
      721 gttcaaccgt ccatgtgcgt ctcgtccata ggctcccgaa gccgggtcag gggtgtcctc
      781 gctaataccc gcacgccgaa atgcctctga attggccaag aacgtatgaa agcacgtacg
      841 agtgagatat actggatgct gatctgtaat ggcatccagc tcggctatac ctggaatttc
      901 aacaggaata aacgcatttt cattccagtt aagtcctaaa atccactctc ccggcggtgt
      961 tacagcgacc cgtttgcgca gcatagccag catctcttcc ttggaggtag ctgatgttaa
     1021 atccagcata gccagcttca taccatgcat agacaaatgc atatgtgaat cggttaagcc
     1081 tggcagtaca taggcgtctt cccaatccac agtttcatat tccttaccgg tcaactgcaa
     1141 ttcaagctcc cgagcatatc cgatggcttg tatccgaccc tgctgtacaa cgatggaatc
     1201 tcctttggaa gcccaatccc catgcaaccg gccgtgcttg aacaaaacga atgtcaacgc
     1261 cactcatctc cttttttcaa ctatacgcat atccacttca tattacgcct gtgttgccac
     1321 ttccaagcgt agtgtattta tatctatctg ctgcacctgc tgggcaaatt ggtcatgagc
     1381 cgcacagaca gccattttat aatcctgatc cagctcatac tgcttaaaat gacaatactc
     1441 ggtggtaaag ccctttgtcg tgaagcctat gaacggttgt gccttcagct cgaatgaaaa
     1501 agacttcaac ggtagagtta gtccctgccc ctcggccttc acaaagcttt ctttaagcgt
     1561 ccatagatcg taaaaatacg ataagcggtt gtctgcatcc tgacgcatta acgcatcata
     1621 ctctgtgtcc gaaaagcaca ctctacctac ctcaaaatca ataggacgga gctgttcaat
     1681 gtcgattcca agcgggtaat catcaatagc gcataccacc cattttcccg agtgagaaac
     1741 attaaaatgg aatgcgggtg catttatcaa ggaaggctta ccgaacgcgt tgtatgtaaa
     1801 ttgaagactg gcattagata ccttcaattg ccggcagacc aaccatctta gcagcacatc
     1861 ggcatataag cccctcaaag catcttcccg atgtaaaaaa cgatctaact tgtgctgctt
     1921 ttccagcgaa acccgattta ccagtaattc gtaatgctcc tcagcttccg gcttgctcgt
     1981 atcaatcgcg tatattttca tggttgcctc ctgtatatct aatgaatatc agccagtttg
     2041 taacactcac cgttcgattg aagtctgtta gatatggatg gcgtgtgccg tgtacatggt
     2101 caatatacta ctctagcact ttcaattcaa tatggataca attgggataa gcatctctat
     2161 taaaactact tcatagagcc tattaatgaa agcgctttaa aataacgcat acagaggagg
     2221 acgaaacaat gaaatatgat tttgcccgct tgctgtgtat tatgctctct attttgctga
     2281 cgttgagcat ttttcagatg ttttctccta agatcgcttc agccgcttca gcgaatgttg
     2341 tgaatggcat tcagtttaaa gatacagatg gaaacgtggt ccatgcccat gggggtggta
     2401 tgattaaagt agatggttac tattattggt ttggtgaaaa tcgtaatccc aacggcacat
     2461 tcaaggcggt atccgcctac cgttcctctg atttaaaaaa ctgggagttt cgtaaaaacg
     2521 tactgaccag cagctccgct gtagagctga atgtttcgaa tattgaacgt ccgaaagtga
     2581 tttacaatga aaaaacacgt aaatacgtat tatggatgca taaggagaat ggggttaatt
     2641 acaacgaggc ccgagtggct atcgcttctt ccgataccgt ggacggcgat tacacgtatc
     2701 agggcagctt ccgtcctctg gatcacgatt cgcgcgatat gaccgtatac aacgataacg
     2761 gtacagctta cctcatttcg gctacccggg taaacgcgga tctgaacatc tatcgtctga
     2821 caccggattt tctgcaagtt gaatcgctgg tgactacact ttggccagga caatatcgtg
     2881 aagctccggc gatgttcaaa aaaggagacg tctacttcct gattacatcc ggggcaaccg
     2941 gctggaatcc caatcaagcc aagtatgcta ccgcatccag cattgaagga acctggagta
     3001 atacgataaa cttcggggac ggtacgacat atggttcaca gtcggcttac gtgattcctg
     3061 ttgaaggtgc ccagacaact tcatacctgt atttgggcga ccgttgggcg ggtgcgtgga
     3121 gcggtcctgt gcaggattct caatatgtat ggctgccact gcgttttcca acagcgactt
     3181 cattagccat ggattggttc gacagcatta atattgacac cgccagtggt gcggtcgagg
     3241 ggataacaac gccaattgcc attgatccgg atgcctatta tcagctagtg aatcgcaaga
     3301 gcaataagcc actaagcatt attggcaatg caacgacgga cggtgcagac ctggagcagc
     3361 gtgcaaattc cggagcagca aaccagcaat ggcagctcaa ggatgcaggc agcggatatt
     3421 ataaaattgt gaaccgcaac agcggaaagc taattggtgt tgaaagcggt accacaacag
     3481 acggtacagt tattgagcag tggagtgacg gaggctggtc cagtcaacat tggcaattag
     3541 tatccgtaac cggtggttat tacaaactga aaaatcgggc aaccggcaag ctgatcgata
     3601 tttctgaagg cgccaccgcc gatggagcca aagccattca atggggcgat aatggtggga
     3661 cgaatcagca tttccgtgta gttaaagtag aatagctcaa gttattttca aaaggagccg
     3721 tattccgagc agatcatggt gactgctaac ggaaaagacg gctccttttt acgtaaaacg
     3781 atgaaattga taatctctag tacgttacag ttcccacgga taatctgttg tcaaaaaact
     3841 agccagctgc ttactttctt ctctccgctg acgccgtatg gctgcgcgtg atggagccgt
     3901 ctggtgcaat tgtaactgct cttctgtttc tggaatcacc tgcgggacgg tcactttacg
     3961 gttgttctcg tccaatgcca caaaggtcag gaaggcggtg gctgcgattt tccggtcgcc
     4021 agtcatcagt ccttcacgaa ttacctttac gaacacctcc atcgagctac ggcctgtcca
     4081 ggttacgaac gcttctagcg tgacagaatc actcggatgg ataggtagca aaaaatccac
     4141 cgaatccgta gaggctgtaa ctgtgttcgt acgacacagc ttagcagctg caatagatgc
     4201 gatatcgtcg atatacgaca ttaatcggcc gccgaagagc gtgttatgat tgttgatatc
     4261 gttgggaaat actcgggacg tcttgaagca gtaggtttct cggatgtact tgctttccat
     4321 ggattctttc ctctcttttc ctcgttgctc tctttttata tctcaggatt ttgcaaaatc
     4381 atgatgtgga agcctgtttt agactatgct aatcatccca ctaatccgca taataaatca
     4441 atacataaaa atcggcatcc tcatccgaat catttcggta ggtatgtatg tcagatactt
     4501 gaaattgcac ggcatcccct gcactcagct tgagctgttg cccctgcatt tcaaagtaca
     4561 tttccccacg gatcatgaga atcgtttcct cccccaaatg cttctctgcc tggtgtgtaa
     4621 aacctggctt cagacttacc gtgaacacct caaacttctt ttcagcgtga tacgggaata
     4681 cagggtaaac aaaatagtta ccgtcctcat caataaccgg atgcaggtct tccctccgaa
     4741 tcttcgtgat ttgcggcgga tcttctttga gaaaggtgga gaaggataca tgcaaaccgt
     4801 tcgcaatttt ccaaagggtt gttaccgtag gattggattt ccccttctca atctgagcca
     4861 gcatcccttt gctgacccct gtcagttcag ccaccttatc caaacttaat cctctaatct
     4921 tcctgatttg agccaaatta gagccaataa tatgctgcat tgaatccacg gacgatgcct
     4981 ccttgtatcc aaaagtctat ataagaagaa tacacaaaag actgtgtgtt cgctatatat
     5041 agactgtatc gtaaaatatc atttatcttt tgcaattttg gatgcatgac ttattatcca
     5101 cagtaaatta agtgtagccg atcaaggtaa tacaaagctt aaacgggaag tagacatgct
     5161 acaatttact gtaattgtaa tatggtcagg ttcctcgctt acttcaacat gcaataaaaa
     5221 catttgacat tgaatataaa tgtccttaaa cttttcactt attaaaactt ttttcaaaac
     5281 tattgtaata tcctgaagga gggctgctat cctatgactt ttccgtccct gaacacccaa
     5341 caggtgagaa aatcaagttt ggctatctag gagggactaa atttgaatct gcaaacccgc
     5401 aagtcccgcc acatgtatac gatgcagctg gcgacaattt ttattggctt tattgtattt
     5461 ggcatctcgg aaaatattaa aggccctgcc attccacgca tccaattcga cttcaatctg
     5521 gatgaacagc agctcggaac attgttgtct ctaaacgcac ttggttattt gattgcctgc
     5581 tcgttcaccg ctgtccttgt ccgtaagtgg ggaatcaagg cggtcagcat catttccttt
     5641 gcttccatga tcatctcggg agtgttcatc tatctgtcgc acacgtatcc gttcttcgcc
     5701 tcgtcctact tcttgatgta tatcgggaac ggcatgctgg agattgcgct cgcaattttg
     5761 ggggcgagga tttttgtgaa aaataccggc acgatgatga atttgtccca ctttttctat
     5821 gggctcagct caacagtcgc ccctttgctg gcgacgggag tcatgtcact gacggtattt
     5881 ggacatatgc tggactggcg ggggatgtat ctggctatgt tgtcgctctg cttgctgccg
     5941 attgtggccg cactgctcag caccttcccg ggagacgatt tgcagcatga ggatcgaacc
     6001 tcactcaaga cgctaacctg cgatccagca ctctggatga tggtaatgat cctgtcgttt
     6061 ggagtagtct ctgagctcgc agttgggggc tggctggtca actttttaga gaaagcgtat
     6121 tcatggaaca cggtgaaggc gtccagcatg ctctcagcgt tctttcttac cttctcgttg
     6181 gggcgcctgt tgcttggtcc actcacagac cggatggggt tcgtgctttc gacgattcta
     6241 ttctccgcct tctcagcgat atgtacgttc gcagcaatcg cgggtggaga gagactggcg
     6301 tttctctttg ccgtatcggg tgcaggtatt gcaatgatct atccgaccgt gatggcgttc
     6361 atagcaagga gatatccgaa ggacagtgat acagctatta cgttcgtcgt cacgctgatg
     6421 ggcataggta gtgtcattgg caactatgtg atcggctggg taatcgaagg ggtcaagata
     6481 gtctacggcg caaccactga gcttggcata ctgcgcggac ttcaggcggg atatggagtt
     6541 atcggtctat gcgcagccat ctgcgcgatc tcgggaatta ttctctacgg atatctgaaa
     6601 aagcggcagg agcttatata aatcaccacc ttagggttgt cccataagtc atgaactgac
     6661 tgggacgccc tttttttacg agttccccat tcagtcaaaa cagcccttgt atgaacacat
     6721 ccgagctgct ttgattcatc atcagttctt gcccgtttgc catttcgaag agctcatcgg
     6781 gagtacattt gaacaccgct tttggatgac tggctgctgc caaatcgtct ggaaccggaa
     6841 cacgaccgaa cctttttggt aaatacatag ccttcattgg gttgtcaaca gtaaaacagc
     6901 tttttaagag caattctcct gtaggaacta ttcaacataa catacaaacg tataatatat
     6961 tgatacttta caacttacgt tatatactat tataaaattt atacactggg ggtaaggtta
     7021 aaatgtccat agcttcggag ttgagcggaa cgaagcacga ttcactcagc tttttacaag
     7081 gggttaaaga ttgtattcct acattgctcg gttatgtatg tattgggttc gcggcaggca
     7141 ttgtgggcgc ttcatcaggg gttagcacca tggaaattgc cttcatgtcg gcgcttgtat
     7201 acgcaggagc ctcccagttt atcatgtgct cgatgctggc tgcagccagt cctccatccg
     7261 tcattatttt aacgactttc attgtgaatg ctcgtcatct gctgttaagt gcgtcgctgg
     7321 ctccttactt ttctaaatat tcattgtgga aaaacatagg catcggtgtt cttttgacgg
     7381 acgaatcctt tggagtagcg tcggataaat tggctaaagg cgggcaggtc agtgaccgct
     7441 ggatgaacgg gcttaatatt acagcttatc tcgcctggat tgcatcctgt gtagcgggag
     7501 gggttctcgg gaactggatt tcccggccgg aggcttttgg tctggacttt gccttgccag
     7561 cgatgtttct tgccctgctc atttcccagc tccaaagtgt ccagacctcc aaactcaagc
     7621 atcgtctgct gcttgtgcta tgtatggctg ttctgatgta ccttttggcc tggtgggtgc
     7681 catcacatat cgccgtcatt atagcgacca tgatcaccgc aacgattgga gtgttaaccg
     7741 acaaatgaac attaatccca atgtcctgta tatcattatc ggtgccatga ttgtcacggc
     7801 gattccaagg atcattccct ttgtcgtgct gcaaaggctg gcgctaccca agccagtgct
     7861 acaatggctt tcctatattc ccatctgcat attcacggcc ctcgtgatgg aaaatctgct
     7921 cgttcgaacc gaaacctcag tcactcttaa tgggcaagtg cttatggctg ttcttcctac
     7981 gctagtgacc gccttgtgga gcaaaaacct gctggctacc gtcgttgtcg gtattgtgag
     8041 tatggctgta attcgacttt tgtggtgaag aaaaaaatta ccctcctaca ataggagggc
     8101 atctgtcctt tcttaggctc cacctgtcgt ccttactaac gagggcgaca gatctccttc
     8161 ctcaaaacca cgttctcgtt gtgaaagata cgaggaggct tgcagcctaa acatttctgc
     8221 atacactccg tctatatcca ttaagtgttc atgactacct gcttccacaa ttttgccctc
     8281 ctccattaaa ataatggtat ccgccatacg tgcggaggac aatctgtgtg aaataaacac
     8341 tccaattttc tcatgaataa gctgatcaaa cttttgaaaa acctctttct ccgcgtgtgg
     8401 atccaaaaaa gagctcggtt catccaagac atatatatcc gcatttctca taaaggccct
     8461 ggctattgca atacgctgcc actgtcctcc agatagctgc tgtccatctt caaaccattt
     8521 tccaagcaag gtattcattt tatcaggcag gccgactatc aaatctgtaa tccccgcctt
     8581 atctatagct gtccaaatgg cctcatcatt ttctctcgaa gccacattac caaagccaat
     8641 attatctcta acagccatct cataatgtac aaaatcctga aaaacaacgc ctatcttttc
     8701 tctaaaactg tctttatcca attcatgtat tgagtgtcca ttaattaaga tttctccttc
     8761 aaaatcggaa tacaaatgag tcagtaactt cacaatcgtt gatttacccg atccatttct
     8821 ccctacaatg gctagcttct ctccttgatg aagcttgaag ctaacattag aaatggcatt
     8881 ctcctctgtg ttcggatatc taaacgatac attccgaaat tcaatactgt gaatagtgga
     8941 caaaggcaat tgctgaaccg ttttttgtat ttttgcctct tccggcatat ccaaaaagtc
     9001 aaatagctgc ttgatataca aattattttg acacaagctt aaaatccctt gtacaatgct
     9061 ctgcgatgtt gactgggtta acgtgatacc ctgaattaag ctcaccaagt tccccactaa
     9121 aatttgacca acataagtgg cttgtatggc catgaaaata ataaatgcac acgcaccctg
     9181 atttacaatc tgaaatacaa gagaggtata ggatctacga accgctagca ctttatcctc
     9241 gcgataaaac ccttcgagta tcgttttata tctttttcgc aaatagtctc ccagttgaaa
     9301 tattttcact tctttaaaac tattatctct tgtcactaaa aacgacaagt accaggattc
     9361 acgttgtctt cctgctcttt gaaagtgaac attaaattct ctttgcccga tacgtaaaaa
     9421 agaataaaat gataagcatg gaatgagaaa aatgaataag aatgcccacc atctccatgc
     9481 gatgagaatc gcacccgtcg aaaataaggt tacaacactg ctaataatgg caaggatttg
     9541 agtaaatatt tcaaacggcc taaaatctgc ctctccctga gcacgttgga gcatattttg
     9601 cacatctgca tcctcaaacg actgcaaaga catcttttgt gctttttcaa taattctgat
     9661 atttacctgg ttcgatagcc ggctttgaaa cattttacga aaaaagcttt cgccaatatt
     9721 gatcagatcg tacagcaaat tgacaccgat caagacgcca aaagctataa aaacaggttg
     9781 aaagctgccc cctgacgctc cggccacgac actgttgatt aattctctcg tggttaaaag
     9841 gatcacagca ggaattgcac ccttcaataa attcgtaatg agtatagcaa tcaaaaagga
     9901 aggatgtgtg tcccaaagca gcctgaatat acgaggccaa aataaaaagg tacgaaatat
     9961 atttttatag gacaaagaga tcaggtcatt ggtttgtcca ttagactgtg acatagctta
    10021 cccctttcct atgcaacagg ttagctactg tatgcttagc taaagccata cattttattt
    10081 ctcgctccct atttacacca agcagacgat tcaaatgcat atgaatgatg ctgcctaaaa
    10141 tatcatcaga aggattggta agttcgtgat tatttttagc caggattatc gcttgagcat
    10201 actgctgaat catagtctgt cttttttcta caagcgctaa gaaagcaacc tgtgtgttcg
    10261 tatctgcttg tccaatccat tcataattcg attctacagc ggtaatcaat gtttttttga
    10321 catccctgaa cgccttcata tgaggcttgc aatcaattct ctcttctagc catttcactt
    10381 gctcctgaat cgttaaacca aaaccactca gataatgaat aatgttaatc acagccgcaa
    10441 tctctatgtc cagattgaaa gcattagagc gaattccctt catataggcg atgacccatt
    10501 gactatccac gtcaaaaacc tgttctgcca gctccataag tgtctgtcct ccatacctct
    10561 ccaattcagg atggtatgta tctatgacca tattcgttat tagcccctct tcacgtaact
    10621 cggctgccca ctgatttaat tgcgccaaac cagctgtcca tagcttatcg ggctctccct
    10681 gaaaacgtaa acggatatga tgttcaggat caacgtatcg caaaaagtaa aattttcgac
    10741 tccaatcctt aaaccccggc tgttttaaga gatgccctag gcttaagcct accaggtcag
    10801 tctctctttc cttgactccg tacaatttaa ggtatagcca ctcccctcct ggaaatatgc
    10861 ctctatgaat gctggaagga gtatgagtaa tgaagttttg agaaacaata tggttttgtg
    10921 aactagggat actcggtttc acctttattt ttttcttctt tagtggaaac acaaattctc
    10981 ccatatatct tcctgccgtc ccctgtactg gggtatggaa gggattaccc aaacactcgg
    11041 taagaagaag ttcctgtcct tcacgtgtct tgctcacctc atgtagcaat tctttgatat
    11101 ggaagaggtt acataggtct aataaaaggc gattatcccc catcgttaga taaacatagc
    11161 gcggtacatt ccattgttgt ctccacacat ggaaaagttc ttctccttct ttggactcgc
    11221 atgattctga aatattcaat gaagctttgc tcagtttcca ctgcgcagca ctaataatga
    11281 tctttttata tactagtctt ggcaaaaaag gggattgctc taatggcccc cagtcaaaat
    11341 aagaccacgt accaatctct ttattggtaa tatccgttag aaatctgaat atatgtggtg
    11401 aaagcttgta attcagcatg tgtgtttgca aggggattat ttccttaccc aaacgtctgg
    11461 acttgacata aaaacgatca tgagtagcac ccaccactaa atcatcaata cagagcgtat
    11521 ggtcctcatc tttagaagag gtggttcccg acacaatctc atatgccatt aaatttttgc
    11581 ttaatgagat atttgatatt ttcccctgtt ccggcataaa aaccatctct gacaataacg
    11641 catcgggatg aaagcatcga tgatgatcat atatttcaga gaatttttgt acaaactcct
    11701 cactaaacat atccagaaaa cgtccaaagg ttttacccgc tctattcgag ccagcactgg
    11761 ctccaagtaa aagcgaatag tctccagaat caactttttc aggagactca gcaaatatac
    11821 tgtaatagat ctccattgat tctggggaag tgtcgtagtt atcagaaatc atcagttgct
    11881 ctaactgttc atctgtaagg gcgagttcta tttcatgatt agaaatggca ttcgaaaccc
    11941 attgaaaaag aacagcgttg cgtttaaatg cctccatgcc cattgatttt ttttcatttg
    12001 aacgatacat ttccggtata cccagacccc aatcctcatc aaacagttca tgaataggaa
    12061 cctcctgata cacaccgtac ttttccaaga aacgattcaa atattcagcc aattcatccg
    12121 ttttggggga tgcatacaat ttgcacatga cttcagcccc taatgaaacc tcatcaagca
    12181 catgtttcgg cagcgttact tctttatcca aaagaacatc aacttgtaca ggtgttttta
    12241 cagaaatgat atccagcatt ttgtcacata atttccggta gaccttctct ccttctccaa
    12301 tcgtgcattg attatattga agtaataaag tatcaatttc gtgtaaaatg tgaatccaag
    12361 gatcggaaat gtccagtttt ttaatttttt cgaatatgta atgaaagggt gaatgatcca
    12421 ttaacggagg tctaagctcg ctcaaaataa actcttgctc tactagttgc tgcaaataat
    12481 cagctatgat ttccaaagta gcgtcaggga atgcctttaa tagtatttct ttcagttcca
    12541 tcacccgaat tggatgttcc gcagcttcaa acgtcattcg aacaacgtca gtaagccgaa
    12601 tggaattaaa aatttctgcc gaatcatcag cttctgctgc tccatgctta ggtcgaaatg
    12661 gtaatttggc tcgatttcct ttgatcataa ccgttttgtt taggaaaacc tttagttgat
    12721 taaatatggc cggatcagct tctatttttt gaatcagttt atatatccat tccatgtcgg
    12781 gtctggctct cttcagatgc ttaggatagc taccaatatc cagatcggtg gtcttcccgc
    12841 aaatcccctg ccccactcct gaaaataacc caaatggagt cgttcgggta gtcatccgaa
    12901 taaaataacg ataaaagctg ttcagcgtct tctcatactt ttgtagctct cctttatcat
    12961 ccaaagcatg accatcattc aagtaatgta aaaactgcat tagggacgga gaggctaatg
    13021 atatggcttc ttgaacaaca gcttcttggg atatcaactt taatcgaaga gttatttcct
    13081 ccaacgtaag ctggctgtcc acatcttgat ccgaaaacac ctgaaaatat cggtctagcg
    13141 atagtaatgg agctctgatt agaaaaaaat cacatgcact aaaccatctt tcatcccgat
    13201 ctctcacttc attatgtagt ttatgcgcat cagtgtaatg cagttgtctc ttcacaactg
    13261 accacctcca agtttttagg aaatatattc aacttgtaac cgattccatg acatgttacc
    13321 agaatttttg gatgacttgg atcatcttct attttctctc tcaattttct gatgtgcaca
    13381 tacaccgtat tagacgtagt aaaagcatcc actccccaga ctctgtctat aatgtgatca
    13441 atcgtagaag cacactcttt tgcagtaaga agatacatta ataatcggaa ttccatcata
    13501 gtcagcatat gctcatgccc ttgcttccaa ataacctttc cagcaggatc aaaaatgaca
    13561 ttaggtgata aactaatagc ctgctgttct ctttccattc catatttaga tgaagccatt
    13621 gaaaacagtt gtttgaggat atccaattgc cgttggtcat cactatgata ggaaagaaag
    13681 ataaatggaa ccttaaattt ttctttaatg ctgtgccagt aagacaagtc ctctagcgtt
    13741 atatgatcct gattcaaagc tacaccgata cactgctcat caatctccgg tatagcctgg
    13801 taaagcgaat cataaaacat gattcgaatg ttttctggag tgcttaaagt ctcaaaaaaa
    13861 tgcttaatct tcctaaaaga tgatataacc ataaattttt gtttcatcta atccccccaa
    13921 aaccaatgct tcagataagc aataaggtag agcgccctta agaaattaga aacaattcac
    13981 tccatctccc tgaatattta ggatgttctt tcccaattcc atagtccagc aaacttaacg
    14041 caatccctgt tgctccttgc agtattccta cattatgaac atgagttgtc ccctccaaat
    14101 cccggtatcc aaatgggagc tcttcatcgt ataaatttac taactttaaa gctatctgat
    14161 cggcaaagtg taaggctgct atattaccgg ttaagctata gaatctatga gccatatgaa
    14221 gcaaaccggc caacccgtga cagaaagtag gggatagcgc gtttagtagc tcatcatcta
    14281 agcaaaatat ggattccata gctttttccg ctatcttttt ccattcttca ttactgcact
    14341 caattcctgc tctgaataat gtccaagcta ttccaaaggt tccatgacac cagccttcaa
    14401 tttctctcat ccctactttt ttctctctct tgttcattga agacgcttga gagtttacag
    14461 gccaatacca gccatattga tcctcctgaa tttgaataag caaaaaatca gctatatgtt
    14521 ttatagcctc atgtagtcct tcaactttga tctttttttg tagggcagtg acaagcagtg
    14581 caagtattcc ggtgatacca tgcgccaaac ctagatggat tgaagtcgaa tctttccttg
    14641 acgacaaatg tatatattca ggtataaagt gcgtaatggt gtctaataat tgacgagaca
    14701 gatcacacat cgtcttgtct tcagcaacct ccagagtgta tctgcccact ccgagcagcc
    14761 cattgatgat atccatttgc ctactgaact ctttaattgt gccaattaca ggtaaacccc
    14821 cccactttac ttcaatatac ttattaagct gagagattag tttgttataa ttagctctgt
    14881 tattggaagc taataatatg ccataagcta ctcctgttgt tccataataa agagaaatac
    14941 gaggcaataa taatagagag ttagcatcta agtaccgtaa ctgactatgc acatgctctg
    15001 cccaattttg atctggctcc aggtaacccc attcggacaa cagcacaaac acacccggaa
    15061 ttccatcggc aagcgagcca ggattccaag gggactttcc acgtgaaggt gaaaggttgt
    15121 ttgtatgatt aactatcttt tctgtatatg ataggtctat tagcttttgt gctatatact
    15181 tactgatttc aactgatctc cccttcaaat cttcaaccat aaatccttcc ctcattttcg
    15241 taactggaaa agacacggtt atagaaaccg tgcctttttt ccatgtattt tcgttattaa
    15301 cacgttttgc agaaggtaag actaacttga caattcaaag tacctgttgc acatgaagga
    15361 gtacagataa gaccactggc tggttgaact ccttttggag caacctcatt tttagctact
    15421 tgcaagtcca gatcaaattg atttttcatc ttgttacctc cttttatttt ttacaatttt
    15481 attataagtt atataatctt aactagactt tatataattc ttacatttgt cttaatttca
    15541 acgagtacat ttaagataaa ccttcattat tttttagtat ttttaaggac aacacactag
    15601 attttagtga caatataatg aagaaaaaat aatggaggct ttcatatgaa aattgatagt
    15661 tttgttatac aacaatccga ccaagttcgt gcaagagata ttagtaaaaa aattgcttta
    15721 cgtctatgcg agcccgaatc cgtctatgca gcagtccatg cggaacacaa tgtttcgcca
    15781 gaaacaaagt accacccatg gggagaaact tcactttcgc atggttatcc tggtaacatt
    15841 catttactat cgcaatggcg tgctacagac ccttcgtatg attggaatag agccatacat
    15901 ttgaacatgg ctcagatcca atcctcactt gctaaaaatg gtcttcacga tctctctctt
    15961 tacagtggct gggcaggcat cgcttcgtcc gtaagagagg cttctaatca tggagaatac
    16021 tacagcaatt ttttacagca aatacatcaa tggatgatgc ctctaacaga gcaatggctt
    16081 cagtcgaaaa cagaacaatt aagccttcac caaggtatgc ccatgcaatc ctttgacacc
    16141 atttcgggag cttcagggat tggaagatat attttgatga actcaaccga tcctatttgt
    16201 actcctcttg ttgaaccaat tcttcaattt cttaccgatc ttacacatcc catacatatt
    16261 cacaatcgtt atgtcccagg gtggtactcc ccgcaaaagt ttcaattttt agaccgggat
    16321 aaacgtaact atcctctggg caattttaat tgtggaatgg cacacggtat tcctggaccg
    16381 ttggctttat tatctgtagc ttacagtgct ggaattgaag taaaaggcca atatcaagcg
    16441 atcgaaacca ttacggaatg gttgcttaag tataaatatg aagatgaata tggtagctac
    16501 tggcctcata ttgttccatt cgaagctgaa acaggctctc tacggtttga tttggaacga
    16561 gcaagagaag catggtgtta cggtaccccc ggcattgcct gtaccctatt tcttgccgga
    16621 aaggctctcc ataatgagga actgcaaaaa ttggctgtga aagcttgtgt cggtgcaatc
    16681 tcctatgaga tagctaagcg ggaaatggac tcttctgcac tctgtcacgg tcttgccgga
    16741 ttacttacca tctcttggcg aatgtggtgt catagtaaag agcctgcttt tctcccgctt
    16801 attcaacagt taacgaattg tctgcttgat tgctttcaaa tggatagccc actaggatat
    16861 ctggaccccg agccaagggc agatggctct ctagtatggc tgacaaaagc gggcatgctt
    16921 gaaggcgttg ctgggattgc agctgcttta ttaagtgttt ctgagaacaa agagatcggt
    16981 tgggattaca tcctcatgct atcctaacta caaccagtcc ctattcacaa acatctttct
    17041 tccaccatac agataggcta aaaacgtaaa aatgacaatc agtccgagac tgtaaggctc
    17101 aactctgggt gcataagtcg ctgtttgcgg catcataata taataaggaa tcgtaaaagg
    17161 aaaccacgca cctatggaag agtgaaagcc tgttataaca atattaggaa ccacacaaca
    17221 aatggacatt cccagagaag ctccaaaatt ccgaattttt atcgagagca taagctgtag
    17281 tgctgccagg ggaaaaatcc cgagccaccc tcccaaaccg gtagaaagaa cgacagacca
    17341 agggatctct cctggagcac ctgctatatt tccacttaca aaatagccta ctataaatat
    17401 aagctgatcc agacccagta tgagaatgag caatatatat tttgcataat aaatttgctg
    17461 acgaggatac gggctgctca ataaaatctt ccatcctcca tcccggtgct cgtacgcaca
    17521 caaaagagaa gcaataattc cacaatagag cggataaaaa aacatagagt gaaattgcgc
    17581 tgaataagta tataaagtta accaactggg tgaaaaaaac tgcttcaaat cattcagttc
    17641 caggactccc attaaagaat ttatgatcgc atccaatata atgagaatcc aaaccatgat
    17701 ccattgaagc tttattgtct ccacgcgtaa aatagagccc atgtatcttt tcctctctat
    17761 ttgaattcat gcttggtaaa ctgtagtgta ccaagtcccg taaagatgac tcctgcactt
    17821 aaagcaacga tcacccaaat catgtgttcc ttcatcagag gacttgataa tgcagggtac
    17881 gaccaaggca atattttaat ccacagaata cttgtgcgtg ccaaaaacaa gcttgcaatt
    17941 gaaccgaata taccaaacgc taatgggaat gcctgattag tgaaaagcgt agacagccaa
    18001 agttgaattg caagtactgg tagggtagcc aagcttgcat taatcggctg taacaacatg
    18061 atccgccaag gaatgggttc gtttgtatat aacacccaga tgaggctcat acctgctaca
    18121 gtgatcaagg cggtacccaa ctgcagaatc acaatccata cgattttgga taaatagata
    18181 taacttctgg gaacaggcat ggccataagc tgcttccatg tttgagtatc atgctctgta
    18241 ccggccataa tactcgccaa aagtgtaccg ccaagcagca tcacaaacga aaggaacata
    18301 aacataacgg caaaaccagc gtagacacct cccggtcctt gccgaaagta aagataccat
    18361 tccacagcag tcatgcctgt aagtacacac ccctgtataa gaggaatcca ccagcatatt
    18421 ttcttcagct taagcccctc tgcctttata acccggagta tcataagctt cgctccttac
    18481 ctgtcagttc caggaatatc tcctccaatg tttttttctt ctctgtgacc cgataaatgg
    18541 gatgattgtg ttccacaagc accttgatca tctccgaaga ttgttgccga tctacaatag
    18601 gagtcacgac ctcattttgt tcaatcgatt cagccccggc cgtccaccca tgctgaatca
    18661 gtgcaccggc agccagaaca ggatctgggg tttcaatgaa taattgaggc ttgcttttgg
    18721 cggtgagttc cttcatcgtt ccctggaaga tcatttcacc ctgattaata attcctacat
    18781 aggttgcaat ctgctcaatt tcgcttaata aatggctcga aactagtacc gtcattccgt
    18841 aagcgccagg gaggctcata attaactccc gaatttcctg aataccagac gggtccaaac
    18901 cattcgtcgg ttcatcaagt atcaataatt tggggttggc aataagcgcc atagcaatcc
    18961 ccagtctttg tcgcatcccc aaggaatatc cctttaccgg acgatacgca tccttggtta
    19021 atctcactaa atccagcact tcatgaattc ttcgggtcgg cagtccacgc atggttgtaa
    19081 cgatttctaa atttcgatat gcggataaat gggcataata ggcaggtgat tcaaccaagg
    19141 aaccaatatc cttcaatatt tccatacgct gatccttcag ctttttcccg aaaatctcaa
    19201 tttccccgga tgtggattta atcagcccaa gtagcatacg aatcgtggtt gttttacccg
    19261 ctccattagg tcctaaaaat ccataaatct gctgtccggg tacctggaga tttattcgtt
    19321 ttacaaattc ccgttttcca aaacgcctag ttagctgctg tgtatgtatt acatattcag
    19381 acatttcctg atctcctctc gacttctaat gctgaagctt aagttacata cagtttactg
    19441 aagtaaagta aacatcaggt aaacagtccc taaacaacag gcaaaaaaac cgagcaaact
    19501 gcaaaatgtg agattagatg ttaaaaagtt agatgtttag cggcagtgaa atctccatcc
    19561 tagtacccgc tttactgcct gaaaggatat gaagcgttcc gttatgcgcc tcaataaagc
    19621 ttttggcaat aggtattcca tgcccttggg aatgagatac ctgcatgtac tcattggaat
    19681 tcattcctat tccgtcgtct tcgatagaaa tatgaagctt atcgttcgct ttgcttactt
    19741 ccatggaaac gtgtgtacct ggaggattat gaatgatagc attaatcaaa aaattctgga
    19801 gcgctctgcc taataattta ctatcgaagg gcataataca tgccgcgtcc attgacgtaa
    19861 aagaaaattc gtattgctcg gctgaaggat ggttagcgat atctatgact gtactacgga
    19921 gaaactccac aatgtccttc ttctccaatt ggattggcaa tggaccttcc ttaagctgca
    19981 tagaagcatt caaatcctga atcaactgct tcatttccgt cactttctca ctgataccca
    20041 tactaaagct tcttctttct tcatcagacc agtcatactc ttgagcagtc agcatgaccg
    20101 catatccttc aatataagat aatggtgttt tcagatcatg gcttacacct gctacccact
    20161 gctgttttcg tttctctatt gccactctct cttcctcatt gctgcgcaat tgggccgata
    20221 agatgttcat ttgttcaaaa acttctttat acaattgata cggaggttta taactatttt
    20281 tctgattttt tttgccctct ggcagttcca gttcacttag cggcgcttgg aattcccctg
    20341 tcgcaatatt tccaatccat ttaattacat acaccaaagg tttgcctata taccatccgt
    20401 aggcagctat gaacacaaca ctctgcacga taccaagtcc tgtccagaat agatcaatat
    20461 ttatattttg agatgctcca aatatacttt ttataaaaat atataagatc gtgcaaataa
    20521 caaaacatag gacataggcc agtacaaagc ataacgttac tttcataaag cgaaaggaca
    20581 tcttaaccag agagttcatt cttgctcccc catcttgact gacatcattt tataaccaag
    20641 tcctcttaca ttgattaaaa attgcgggtg cttgggatca ggttctattt ttttccgcaa
    20701 acgggagata tgaatcacta cggtcttctc atcacccaag aaggcctcgc tccatatcgc
    20761 ctcataaagc tgccgtacac tgaaaatacg gttaggatgc ttgcacagaa ataccagcag
    20821 tagccattca cgtgccggac aatcgacctg cttgtcctcc acatacaata caccggattc
    20881 cagttccaga cgaaaatatc caaaatctaa agtgcgtaag gtcggtttca tggccactgt
    20941 cgaaactttc cgatatttca ttcgagcttt catacgcgca acgacttcca gcgggttaaa
    21001 cggtttggta atataatcgt cccctccgat accaaacccc attaatttgt ctaggtctgt
    21061 atctcttgcc gtcaaaaaaa gaataggggc atccgtatat agacgcattt gacgacatac
    21121 ctcaaaccca tcgttatcag gcagcataac atcaagtaca atcacatcca catgagattc
    21181 catcacgact tgcagcgctt cccgacccgt tgcagcatgc ttgacttgaa ggaatccttc
    21241 tttttttaac accgttgtca gcatatcccg caacccctgc tcatcgtcta ctataagtac
    21301 tgcaatttct tccataaccc aaggttctcc attctttttt tacatttttt actttcatta
    21361 taaaagcaaa cgggcagaat ttaaatcgag ttccatcaca tatcgttcat ccccgtgaat
    21421 atacttaata accaacaagg ccaaactgtg ccgtgtatcc acttgggggg tgcctaataa
    21481 tgccggaacc acgccagcca tattcattcg tcgtatcccg cgaagattgg tcgctgcatc
    21541 gcaaagggta ccaggaccag caacgtcatc agcagaaggt caaagatgtc attaagcaaa
    21601 atctacccga tctgataacg gaagaaaata ttattatgtc ggacggtcaa cagattatta
    21661 aagtgccgat tcgcagtctg gatgaatatc gcttcattta taactatcaa aagcaaaagc
    21721 atgtaggcca aggagatggc gacagtcagg tgggggatgt cattggacgt gatcctgctt
    21781 cccagaagcc aggtaaaggt gagaaagccg gcgaccagcc gggacacgat attatggaaa
    21841 cggaagtcag catagaagaa ctggaagata tgctgtttga ggaaatggaa ttgccgaatt
    21901 tacagcaaaa agacaaggat caaattgagg ttgaatctat cgtatttaat gatatacgta
    21961 aaaaaggcat gcaagcgaac attgacaaga aacgaaccat tctcgaaaat ctgcgccgca
    22021 acgcccgtga ggggaaaccg ggcattcacc atattagtcc ggacgatctt cgctacaaaa
    22081 catgggaaga gaagaccatt ccccaatcca acgcggtgat tatagctatg atggacacct
    22141 caggttcgat gggctctttt gaaaaatatt gcgctcgcag cttctttttc tggatgaccc
    22201 gctttttgcg ccgtcagtac gaaaaggtgg aaattgtctt tctcgcgcat cataccgagg
    22261 ctaaagaggt tacggaagaa gaatttttta cccgcggaga aagtggcggc acaatctgct
    22321 cttccgctta tttgaaagca ctggagatta tcgacaaacg atatcctcct tccagctaca
    22381 atatttatcc cttccatttc tcggatggcg ataacctgac ctcggacaat gagcggtgtg
    22441 tgaagctaat cgaggaactt ataaagcgga gcaatatgtt cggctatgga gaagtgaatc
    22501 aatataatcg cagcagcacg ctgatgtcag cctacaagaa tattaaaaag gatcagttta
    22561 tgtactatgt catcaaggaa aaaggtgagg tataccaagc cttacgtacc ttttttcgca
    22621 aacgggaagg gggatcggtg ggatgagtac cgaccagaag gagctagaat atgcgatatc
    22681 agaaattatg gagattgccg atggattcgg gctcgattac tacccgatgc ggtatgagat
    22741 ttgtccggcg gatattgtat acacgttcgg agcctatggt atgcccacgc gcttcagcca
    22801 ctggagtttt ggaaaaacat ttcacaagat gaaaatgcag tacgattttg gattgagcaa
    22861 aatctatgag ctggtcatta actccaatcc ctgctatgcc ttcctgctgg aaggaaattc
    22921 tttggtgcaa aataaactga ttgtcgccca tgtactggca cactgtgatt ttttcaaaca
    22981 caacgctcgc ttctcagctt ctaatcgcaa tatggtagag agtatgtcgg ccacagcaga
    23041 tcgaatcaac agctatgaag tggaatacgg gtcagaggct gtggaatcct tcattgactc
    23101 tgtactggcg atacaagagc atgtagaccc acagattatc aaaccaaggc atctggataa
    23161 acaacgctat atggagctca aaatccggga gcagaaagaa cctggaaaac gccagcgccc
    23221 tcctgggcct tacgatgatc tatggtcact ggaaacagcg aagcagcatg atccgaccga
    23281 gaccgagggc atcaaggtac gcaagttccc accggaacct gaaaaagata tcgtctggtt
    23341 tattcaggaa ttctcggagg tactggagga ctggcagcgg gatattatga cgatgctacg
    23401 ggacgaaatg ctgtatttct ggccccaaat ggagaccaaa atcatgaatg aaggctgggc
    23461 ctcctattgg caccagcgga ttgtaaggga actggattta accggggagg aaaccgttga
    23521 atttgcgatg ctgaacgctt ctgtcgtaca gccttccaag caaagcctga acccgtacta
    23581 tttgggactg aaaatatttg aggatattga aaaacgatgg gataacccaa cccgtgagga
    23641 gcaagagcga caaggacgca aaccgggcga aggacgcgct aaaatgttcg aggtacgaga
    23701 gttcgactca gacacctctt ttatacgcaa ttacatgacc aagaaactga cagaggattt
    23761 ggatctgtac gtgtttgaga aacggggacc cgattggaaa attaccgata aatcctggga
    23821 aaacatacgg gatcagctcg tgttttcacg tgtgaatgga ggctcccctt atatcgtcgt
    23881 cgaggatgga gattacctgc atacgggcga gttgaagctc aagcaccagt acgaaggcat
    23941 tgagctggat ttaaaatata tggagcgcac acttccgtat gtatatcagc tgtgggggcg
    24001 caccgttcat ttggaaacat tgattgaggg taagctcgcc ttattctcat atgacggtaa
    24061 gaaacatcat cgtaagtttg tatagtcata caaaatcaaa tagccagcct aatttaaaaa
    24121 aggggcattc ctaaaaagga tatgcgcctt ttttttacta tttcatacaa ccttaagcga
    24181 ccttcgtttc ttgccaattt caggacacct gtttcgtttt ggatcagggg tgtattatac
    24241 taatatgata aatgacccac gggtcatagt tgagaagcag aacgaggagc gttgatatag
    24301 atgaacaccc atcccagctt tcgtgaagtt cgtgaaagtg atcagcaggt attcccgatc
    24361 gcctggtatg ccgttggctg gtccaaggaa ctaaagaata aaccgcttaa aaagcgactg
    24421 cttggcaaag atattgtcct gtaccgtgat gatcatcgtc aggtacatgc catccatgct
    24481 tattgcccgc accgaggagc tgatttgtcg cacggctatt gtcaaaacgg gcacatcaca
    24541 tgtccatatc atgcatggtc tttcgatgag agtgggcagt gtgtggatat tccggcacat
    24601 ccgggacggg ctattcctga atttgctcat acctatgcct atcccgcgat tgaaaaagcc
    24661 ggtctgctgt gggtatatcc tcaggccgtt ggctcaaagt ctgagataaa ctcagggttg
    24721 ggaacatcca catccccccc tcctctggag atttttcccg agctggagga cccctctctc
    24781 attttgtctc cctacgattc cgtgtggaag gcacatctga cgagagttgt ggagagcgtg
    24841 ctggatgtcg ctcatttgcc aattgtccat aacaaaacga tcggtaaaaa atcctccacc
    24901 gacattcata tcgagtttga agcggatgac aatcatattc gagtgaaaaa cgggaaaggt
    24961 ctattacaat atacctttcc acagcaatgg attttgactc ccgccaagga aggacgcagc
    25021 aagtttatta atttcgtcac cttcactccg attgagcaag agttaactgc catctacgga
    25081 ctggctggac gtaattttgc cagatttgta ccgggcatgg gccacatttt ttccagatac
    25141 agtggcaagg tgctggaaga ggatcgggcc gtagtggaaa gccagcatcc gcgtccaatc
    25201 ccagaagcgc tgcgaatgga ggcacacgtc cccgctgatg gacctcaggt tcggtttcgc
    25261 aaccgctggt atgatttcct tgtcaacgat gagcctcgtg tacgactggg tccagaaact
    25321 acttcctctt aaattcgacg atgtagcttt gattgagctg ttttccacct tccgagatgt
    25381 tctggtacat ggataaaaac cgggcggatg ggctccatac cgttgggctg tcataggatt
    25441 ggatatcggt cgtaaccgga gtggttttac ccgtagactg gtcaaacaca tacagccctc
    25501 tcatgccttg ctgatcctca tcataaatgg aataagcaag cttggacccg tcgctggacc
    25561 agcttccacg actcattaaa gtgccttgac cgacgattcc tttctctttg ccctgttcat
    25621 ccaaaatgat catacgggct ggttcggatg tattccattt ccgcttttca atggcaattg
    25681 acttaccatc aggcgacacg gcaaaggaca tggcaccctc tgcaatggtc acagcctgag
    25741 gatgattgag ggtgaaccga ttcagcaccg gatacccttg tttatcactg cctgtataaa
    25801 atatggcgtt acccactttt tcgacatgag acatcaattc agagcgattc ggatcttgaa
    25861 aactcaattc tttagctttt ccgtccagac caatcagctg gattttacca tccggtgtgc
    25921 ctgtaatgag atcattctca tcgctccagc tcacttcgtt agtcatatcc agcttgccga
    25981 tcgatgtaac cttaccactg cctagttcca aaatgtagcc ttgaatatca tatttgctgc
    26041 tggtgctacc ttcagtaaaa aagacatggc gctgatccgg tgataccaca gcaagtaact
    26101 gtggagcctt acgacctggt gttaaaatcc gctccttgtc tgtctctaca ttatgaatcc
    26161 acagctgggt tttacgctcc acaatcagct cttcgtcgct cagccaagac ctcgcgtaga
    26221 catcccccag cctgtcgata gacgatacca ccagctcgtc cgttacttgc tgctgggctg
    26281 catccgtgtc aatcacagta agctgttggc ccggtttcat accggatgct ggatttgtct
    26341 ctcctgcgct cttcatgccg caaccgctga acaatgcccc ggcgattaag ccggtcatga
    26401 gcacccccgt ggctttctgt ctgaaaactc ttgtacggga atcttcgcga tgagaggagc
    26461 cgttcttttg cccatagctg cctatgtttt tctttatcat gtataacggc ctccttgtta
    26521 acgatacccc cagtttaatg cccgaacatc tcatgaatac atcggattgt ttccaagttg
    26581 taaacaagac accattttag ccctgtgcta acagttggcc atttacaggg agccatcgtg
    26641 aaccaagaga gggagtctaa gcgaaaattc attcccactt acatttgtat gcccgttgtc
    26701 attttccaac ccactatgat ctgaagctgt aagctgcaac tctcccccca tgcgctccgc
    26761 cagtctgcgc gccagaggaa gaccgagtcc cgtaccgctg tcctgacgag atcgatcacg
    26821 acttaaggta gcaaacggct caaaaatcat gtcccattgc tccctaggaa tccatgggcc
    26881 ggaattgcgt atacacacaa tcacggtgtc ctgttctact cgattcgata acgtaatcca
    26941 tccaccgtcc cgattgtact tcactgcatt atccagcaaa ttcagtacaa tatgcatcag
    27001 atgctta
//
