LOCUS       NZ_CP107567            10219 bp    DNA     linear   CON 18-NOV-2023
DEFINITION  Streptomyces peucetius strain NA0869 chromosome, complete genome.
ACCESSION   NZ_CP107567
VERSION     NZ_CP107567.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces peucetius
  ORGANISM  Streptomyces peucetius
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8050611)
  AUTHORS   Zhao,E. and Ge,H.
  TITLE     Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis
            of Trialkyl-Substituted Aromatic Polyketides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8050611)
  AUTHORS   Zhao,E. and Ge,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2022) School of Life Sciences, Nanjing University,
            No. 163 of Xianlin Avenue, Qixia District, Nanjing, Jiangsu 210033,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: unicycler(0.4.8) v. v. 3
            Assembly Name                     :: NJU_NA0869
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/18/2023 06:49:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,216
            CDSs (total)                      :: 7,126
            Genes (coding)                    :: 6,825
            CDSs (with protein)               :: 6,825
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 303
            CDSs (without protein)            :: 301
            Pseudo Genes (ambiguous residues) :: 0 of 303
            Pseudo Genes (frameshifted)       :: 144 of 303
            Pseudo Genes (incomplete)         :: 227 of 303
            Pseudo Genes (internal stop)      :: 22 of 303
            Pseudo Genes (multiple problems)  :: 85 of 303
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:23:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 559451
            Orig. end                         :: 569670
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP107567.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from IFB-NA0869, Nanjing
            University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10219
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10219
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10219
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5219](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5219)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(1276..1291)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.6"
                     /tool="antismash"
     gene            complement(1735..4044)
                     /locus_tag="OGH68_RS02675"
                     /old_locus_tag="OGH68_02675"
     CDS             complement(1735..4044)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320917.1"
                     /locus_tag="OGH68_RS02675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OGH68_02675"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_264241691.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.2e-37, bitscore:
                     125.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQTDHNAPAPGRQLPPAGRGRHRPEAAAQGGRRGGSRRAAPPAR
                     RKQRRTRQPRAVRTPTVLQMEAVECGAAALAMVLSHYGRHVPLEELRIACGVSRDGSRA
                     SNVLKAARSYGLTAKGMQMEASALAEVQPPAILFWEFNHYVVYDGTARRFGRRGVHIND
                     PDKGRRFVPEEDFDTSFTGVALVLEPDRNFRKGGRKPGIMSAVPARLRGTAGTLFAAFL
                     ASLLLVAVGAAVPALSRTYIDMFLIGGRTSLLGTLFTAMAVMVALTAVLTGLQQANLLR
                     GRLISSTLSSARFLRHLLRLPVTFFAQRSPADLVQRLQSNDAVAETLARDLAAAAVDGI
                     VVILYAALLWSYDPQLTVLGVLIALLNIVAMRIVIRLRATHTQKLRADSARLTNTSYTG
                     LQLIETMKATGAENGFFRRWAGQHATTLDVQQRLGVPSAVLAIVAPTLATLNSALILWI
                     GGLRAVEGHISIGLLVAFQALVARFTAPITRLNGVAGRIQDFAADMTRLKDVESFPVDP
                     LYSRDEPDPSSRRLKGHVTLENITFGYSPLDAPLLSGFSLTVGPGQQVALVGGSGSGKS
                     TVSRLIAGLYSPWEGTIRIDGRLLADIPRGALAASVSFVDQDIFLFEGTVRDNVTLWDP
                     SVPDEAVENALRDAAVHDVVMRRPDGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSIL
                     VLDEVTSALDAETERIIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGTVVERGRHE
                     DLVAAQGPYAQLVKEY"
     gene            complement(4041..4847)
                     /locus_tag="OGH68_RS02680"
                     /old_locus_tag="OGH68_02680"
     CDS             complement(4041..4847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="OGH68_RS02680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OGH68_02680"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_264241692.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEEIDLPVRFARPQGLLVLIVTVVVMIVASAW
                     AVTGTVSSTLDAPGILTHAQGSYVLQSPVAGQVTEVLAEEGDRVRADAPLLNVRTAQGD
                     TVVRTVAAGRVTALVATIGSVVTPGSDIAAVERIEKADDPLMAVLYVPAGSGASVPVGA
                     KVDLSVQSVPAQQYGVLRGRVKAVGRTAQTRQRITAFLGSSQLGEQFSQAGQPVAVLVA
                     LDRTEGTGSGYRWSSSDGPPYPLESMTLTGGAVHLAEQRPIDWLLP"
     gene            complement(5001..5219)
                     /locus_tag="OGH68_RS02685"
                     /old_locus_tag="OGH68_02685"
     CDS             complement(5001..5219)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008412458.1"
                     /locus_tag="OGH68_RS02685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OGH68_02685"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_264241693.1"
                     /sec_met_domain="strepbact (E-value: 4.1e-21, bitscore:
                     74.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFVPTQEIADSELDNVAGGLHSHTVDNVLAAADIIAPVSGTVAT
                     ATGLVAGATGINAAAISGPAAGIVAGL"
     misc_feature    complement(5455..5468)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.06"
                     /tool="antismash"
     misc_feature    complement(5456..5469)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.91"
                     /tool="antismash"
     misc_feature    5456..5470
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.64"
                     /tool="antismash"
     misc_feature    5460..5475
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.63"
                     /tool="antismash"
     misc_feature    complement(5591..5609)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.72"
                     /tool="antismash"
     misc_feature    5709..5724
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(5720..6667)
                     /gene="opcA"
                     /locus_tag="OGH68_RS02690"
                     /old_locus_tag="OGH68_02690"
     CDS             complement(5720..6667)
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /GO_process="GO:0065003 - protein-containing complex
                     assembly [Evidence IEA]"
                     /codon_start=1
                     /gene="opcA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320914.1"
                     /locus_tag="OGH68_RS02690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OGH68_02690"
                     /product="glucose-6-phosphate dehydrogenase assembly
                     protein OpcA"
                     /protein_id="WP_264241694.1"
                     /transl_table=11
                     /translation="MKTDLTDTTASKINKALVRGRREIGTPAVGMVLTLVIVTDEENAY
                     DAIKAAGDASREHPSRTLVVIKRHARSPRERHEARLDAEVRLGSDAGAGETVLLRLHGE
                     LTQRADSVVLPLLLPDAPVVVWWPVDAPPVPAKDPLGALAQRRITDAYAVERPIEELDA
                     RAAGYEPGDTDLAWTRLTPWRSMLAAALDQARAEVVSAVVESEADNPSAELLARWFTAR
                     LKVPVEQVVTEGPVVTAVRLRTVDGEIHIDRPEGPVARLSIPGQPTRVLALKVRSTAEL
                     IAEELRRLDPDEAYAAALHAAVTAPAPEKAADTM"
     gene            complement(6664..8247)
                     /gene="zwf"
                     /locus_tag="OGH68_RS02695"
                     /old_locus_tag="OGH68_02695"
     CDS             complement(6664..8247)
                     /GO_function="GO:0004345 - glucose-6-phosphate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="zwf"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320913.1"
                     /locus_tag="OGH68_RS02695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="OGH68_02695"
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="WP_264241695.1"
                     /transl_table=11
                     /translation="MSQNGSQSRSQHRARRRSQGSGWANPLRDPLDRRLPRIAGPSGLV
                     IFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARREWQDQDFAEEVRQAVREHART
                     PFREEVWNQLSEGMRFVQGDFGDNAAFEQLKATVEDLDRSQGTGGNFAFYLSVPPKFFP
                     EVVQQLKDHGLSDAPEGSWRRAVIEKPFGHDLTSACDLNEIVHEVFAPDEVFRIDHYLG
                     KETVQNILALRFANTLFEPIWNRSYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNH
                     LLQLLALTAMEEPASFDADALVTEKLKVFKAVKVPADLARSTVRAQYAAGWQGGEKVLG
                     YLQEEGIAPDSRTDTYAAIKLGIDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPHSP
                     FDSSATEELGENALVIRVQPDEGVTVRFGSKVPGTSMELRDVTMDFAYGESFTESSPEA
                     YERLILDVLLGDANLFPRTEEVEESWRILDPVEEFWDRSGEPAQYPAGTWGPAEADDML
                     ARDGRSWRRP"
     misc_feature    complement(8297..8311)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.7"
                     /tool="antismash"
     misc_feature    8390..8404
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.88"
                     /tool="antismash"
     misc_feature    complement(8412..8426)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.09"
                     /tool="antismash"
     gene            8542..>8601
                     /locus_tag="OGH68_RS02700"
                     /old_locus_tag="OGH68_02700"
                     /pseudo=""
     CDS             8542..>8601
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012551.3"
                     /locus_tag="OGH68_RS02700"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="OGH68_02700"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPVDGVGLQGHFAVQYGFPS"
     misc_feature    complement(9350..9368)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.42"
                     /tool="antismash"
ORIGIN
        1 ttgttcagct ccaccagtct gcgctgccag cggacctgcc acaggcccat gccgaggaac
       61 accgctccga tgacgagcag cattccgatg gcggcgagcg ccagcggcac gctgtaccag
      121 agcagcagga cgacgttcat cgtgccgacg gtgaccgact gcagggccac cgggccggtg
      181 ccggacagga cccggcggat ggagctgatg cccatggcgg cgctggccag ttctccggtc
      241 gaccgctccg cgaagaacct ggtgggcagc cgcaggagcc tgtcccagac ggcgggctgc
      301 agggtgctct cgatgcggcc ctccatccgc aggacggtca ggttctgcag cagcatgaag
      361 gcggcggaga cgacgctcgc gatcatgacg gcgagcgaga cctggacgat caggcctgcc
      421 tgcgcgttgg gtacgtagac accgagtacc tttccggtgg cgatgggcac gagcgcgccg
      481 agcacgacgg tgacgagacc ggagatcagc aggttccgca ggtccatgcg ggtgccgcgg
      541 agactgaagc gcaccagccg ccggaggttc gaaggctgct cgggcagcgg ccggtagaac
      601 atgacggccc ggtcctcgaa ctcgtccgcg ttctccgtgc cgatccgcgt ccgtgagccg
      661 gtgaccgggt tgaccgcctc gtagcgtccg cggcgccaga tcagtgcgac gggcgcgccg
      721 gaggctgccc ggtggcccac gagcgggccc gcgtcgctgc gccaccaggg gccctggagg
      781 cggaccggac gggtgcggac gcgggaggcg acggcgatgc gttcgacggg gccgacgcgg
      841 tccccgccaa agccgctctt cggcgggtcg gtcagggtga tcccggcggc gcgggcgaca
      901 tggcggcaca ccgcgaggag cgtgtcgtcg ccgtccgctc ccccgtggcc gcgcgaggcc
      961 cggtcccctc tgccgatgga ggcgagcagt gcctcgtcgg cgcgggcacc ggcgtcggca
     1021 ccggccttga taccggcggc cgtccggtcc tcgtgggccc gctccagttc ctcgatccag
     1081 ccgtccacgg cggacagcaa ccggtactgc tggttcacca tgcgctgcca caaggcgccc
     1141 tcgacgagca ggtcgcccgc cgcctccgca ctgtaggagg cgccgtactg cacgctgccc
     1201 ggctcgacct gcatccacag gacgtcgtcg tcggccaggg cctcctctgt ggcggggcgg
     1261 ccctccagcg gcgcctcgaa cagcactccg aggccgcggc cgacgcccag gccgaaggcg
     1321 tactcgagct gggtggcggc cgtccggccg taaggatcct ggtacgcggg cgggtacggc
     1381 tccccgtact ccggcacgta cagctcccgc agcgggatcc ggcgcaacag acagtcctgc
     1441 gagggccggc cggtcagggt gtgccgggag ccctcgaccg ggccgaggag gagcgtgccg
     1501 ggttcgagac ggccgaggaa gtgccagtgg ccctgttcga cggcgtccac ggcgaacagg
     1561 tcgagcgcgc cgcccatgac gagccacagc accagcggcc cttccagcgg aagactgcgc
     1621 agaccggtgc agtcgacggg cgttcccagc ccgccgagtg cgtggatcac cgcgtcggac
     1681 tgtgcgggcg cctggtggtg gccgccggtg ggcggcaggt ggacggacga cacgtcagta
     1741 ctccttgacc agctgggcgt acggcccctg ggcggccacc aggtcctcgt ggcggccgcg
     1801 ttcgacgacg gtgccgtggt cgagcacgac gatctcgtcg ctgtcgcgca cggtgctcag
     1861 ccggtgggcg atcacgacgc aggcgcagcc gcgccggcgc agattgtcga tgatgatccg
     1921 ctcggtctcc gcgtcgaggg cgctggtgac ctcgtcgagg accaggatgc tcggccggcg
     1981 taccagcgcg cgggcgatct cgaggcgctg gcgctgtccg ccggagaagt tgcggccgtc
     2041 ctgttcgacg cggctgtgga tgccgtcggg gcggcgcatc accacgtcgt ggaccgccgc
     2101 gtcccgcagc gcgttctcca cggcctcgtc cgggacggac gggtcccaca gggtcacgtt
     2161 gtcgcggacg gtgccctcga agaggaagat gtcctggtcg acgaaggaga cggaggcggc
     2221 gagcgcgccg cggggaatgt ccgcgaggag acgcccgtcg atgcggatgg tcccctccca
     2281 cggactgtag aggcccgcta tcagccggga gacggtggac ttgccgctgc cggagccgcc
     2341 gacgagggcc acctgctgtc ccgggccgac ggtgagggag aaaccgctga gcagcggcgc
     2401 gtcgagcggg ctgtagccga aggtgatgtt ctcgagcgtc acatggccct tgagccggcg
     2461 gctgctcggg tcgggttcgt cgcgggagta gagagggtcg acggggaagc tctccacgtc
     2521 cttgagtcgc gtcatgtccg cggcgaagtc ctggatccgg ccggccacgc cgttcagccg
     2581 ggtgatgggc gcggtgaagc gggccaccag tgcctggaag gcgacaagga gaccgatcga
     2641 tatatgtcct tcgacggctc gcagtccgcc gatccagagg atgagagcgc tgttgagggt
     2701 ggcgagggtg ggcgccacga tggccagcac ggcgctgggc acgccgaggc gctgctggac
     2761 gtccagagtg gtggcgtgct ggcccgccca gcggcggaag aagccgttct ccgcgccggt
     2821 ggccttcatg gtctcgatca gctggaggcc ggtgtacgag gtgttggtga ggcgggcgct
     2881 gtcggcgcgc agcttctggg tgtgggtggc gcggagccgg atgacgatgc gcatcgccac
     2941 gatgttcagg agcgcgatga gcactcccag cacggtgagc tgcgggtcgt agctccacag
     3001 cagcgcggcg tagaggatga ccacgatgcc gtcgacggcg gcggcggcga ggtcacgggc
     3061 gagggtctcc gccacggcgt cgttggactg cagccgctgc accaggtcgg ccgggctgcg
     3121 ctgggcgaag aacgtgacgg gcagccgcag caaatggcgc aggaaacggg cgctgctcag
     3181 ggtggaggag atgagccggc cgcgcagcag gttcgcctgt tgcagccccg tgagcacggc
     3241 ggtcagggcc accatcacgg ccatggcggt gaacagcgtc ccgagcagcg aggtacggcc
     3301 gccgatcagg aacatgtcga tgtaggtacg gctcagcgcg gggaccgccg cgccgaccgc
     3361 gacgaggagc aggctggcga ggaaggcggc gaacagggtg cccgcggtcc cgcggagcct
     3421 tgcgggtacg gccgacatga tgcccggctt gcggccgccc ttgcggaagt tccggtccgg
     3481 ctcgagtacc agggcgaccc cggtgaagct ggtgtcgaag tcctcctccg gcacgaaccg
     3541 gcggcccttg tcggggtcgt tgatgtgcac gccgcgccgg ccgaaccggc gtgccgtgcc
     3601 gtcgtagacc acgtagtggt tgaactccca gaacaggatg gcgggcggct gcacctcggc
     3661 gagcgcggac gcctccatct gcatgccctt ggcggtcagt ccgtaactgc gggccgcctt
     3721 gagcacgttg ctggcgcgcg agccgtcccg ggagacgccg caggcgatcc ggagttcctc
     3781 gagcggcaca tggcgcccgt agtgggagag gaccatggcg agggcggcgg caccgcactc
     3841 gacggcctcc atctggagca cggtgggggt gcggacggcg cggggctgcc tggtgcgccg
     3901 ctgcttgcgg cgcgccggcg gcgcggcccg gcgcgacccg ccgcgccggc cgccctgggc
     3961 cgctgcttcc gggcggtgcc tgccgcgtcc cgcgggcggc agctgccggc cgggagcggg
     4021 tgcgttgtgg tcggtctgtg tcacggcagc agccaatcga tcgggcgctg ctctgcgagg
     4081 tggacggcac cgccggtcag ggtcatggat tcgagcgggt acggcggccc gtcggaggac
     4141 gaccaccggt agccggaccc ggtgccctcg gtgcggtcca gtgcgaccag cacggcgacg
     4201 ggctggccgg cctgcgagaa ctgctcgccg agctggctgc tgccgaggaa cgcggtgatc
     4261 cgctgccggg tctgggcggt cctgccgacg gccttgaccc ggccgcgcag cactccgtac
     4321 tgctgtgccg gaaccgactg gacgctgagg tcgaccttcg cgccgacggg caccgacgcg
     4381 ccgctccctg cggggacgta cagcaccgcc atcagcgggt cgtccgcctt ctcgatccgt
     4441 tcgaccgccg cgatgtcgga gccgggcgtg acgacggacc cgatggtggc gacgagcgcg
     4501 gtgacccggc cggcggcgac ggtacggacg acggtgtcgc cctgcgcggt acggacgttc
     4561 agcaggggcg cgtcggcgcg gacccggtcg ccctcctctg cgaggacctc ggtgacctgg
     4621 ccggcgacgg ggctctggag tacgtaactg ccctgggcat gggtgaggat gccgggcgcg
     4681 tccagcgtgg aggacaccgt gcccgtcacg gcccacgcac tcgccacgat catcacgacg
     4741 acggtgacga tcagcacgag caggccctgg ggccgggcga accgcaccgg aaggtcgatc
     4801 tcttccggcg actgcagctt ggaaagggcc tgttggcgga actgcacgat gctcttgcct
     4861 caactgcggg ggatacgggg agattcgtac gtggcactgc cggaagcagg gacgcacgac
     4921 tgtgtgcccc ggaacctggc cggctccggg gcacacagct cggctgtgcc ggcagagcgg
     4981 ttgccggcga gccgtgggac ttagagaccc gcgacgatgc cggcggccgg gccgctgatg
     5041 gcggcggcgt tgatgccggt ggcgccggcg acgaggccgg tggcggtggc gacggtgccg
     5101 gagaccgggg cgatgatgtc agcagcggcc aggacgttgt ccaccgtgtg gctgtggagg
     5161 ccgcccgcga cgttgtcgag ctcggagtcg gcgatctcct gggtggggac gaagctcatg
     5221 agaagttccc ttcgggtgga tatgcaaatt actgcgcccg gccgctcgaa agagcgaagc
     5281 cggtcgccga gcgggcgtgg ggggattccc ggatccggga accgtcttcg aatcccgcag
     5341 tgcgaaggat caaagcatgt aagggcgttg agcagccaat cgcgaggagc ggatctgcac
     5401 agaaagcggc tactcattac tgccgcgtgg acacccctgc atgaatcggc tccattttct
     5461 tcaccaaatg gtcgaactcg cggcccaccg aggctcccgg ccggcgggcg gcgaagtgga
     5521 cattcccgcc cagaggcaga tagttgcagg tcagcccggg gatggggttg aggaggcgat
     5581 gtgccgcctg agcattcggt gtgcagattc gcggcagacc gcgggcgcct gacgccgcct
     5641 cacaaaaatg cacaaggggt ggagcgaccg ccgcgctcca cccttcccct gagtcaccga
     5701 gtaattgcgg tgagtttcct cacatggtgt ccgcggcctt ttccggcgcg ggcgcggtga
     5761 cagcggcgtg cagtgccgcg gcgtatgcct cgtccgggtc gagccggcgc agttcctcgg
     5821 cgatgagctc cgccgtgctc cgtactttca gggcgaggac ccgggtcggc tgcccgggaa
     5881 tactcagccg ggcgacgggc ccttccggcc ggtcgatgtg gatctcaccg tccacggtgc
     5941 gcagccggac ggcggtgacc accggccctt cggtgacgac ctgttcgacg ggcaccttca
     6001 gccgggcggt gaaccagcgg gcgagcagct cggcgctggg attgtcggcc tcgctctcga
     6061 ccacggcgga gacgacctcg gcccgcgcct ggtccagcgc ggcggcgagc atggagcgcc
     6121 acggcgtgag ccgggtccag gcgaggtcgg tgtcgcccgg ctcgtacccg gcggcgcggg
     6181 cgtccagttc ctcgatcggc cgctccaccg cgtacgcgtc ggtgatgcgc cgttgcgcga
     6241 gcgccccgag cgggtccttg gcgggtacgg gcggggcgtc caccggccac cagacgacga
     6301 cgggggcgtc gggcagcagc agcgggagca ccaccgagtc ggcgcgctgg gtgagttcgc
     6361 cgtgcaggcg cagcagcacg gtctcgccgg ctccggcgtc gctgccgagg cgcacctcgg
     6421 cgtcgaggcg ggcctcgtgg cgttcgcgcg gcgagcgggc gtggcgcttg atgacgacga
     6481 gggtgcggga ggggtgttca cgggaggcgt ctcccgccgc cttgatggcg tcgtaggcgt
     6541 tctcctcgtc ggtgacgatg accagggtga gcaccatgcc gacggccggg gtgccgatct
     6601 cgcggcggcc ccggacgagc gccttgttga tcttgctggc cgtggtgtcg gtgaggtcgg
     6661 tcttcatggc ctgcgccagc tccgtccgtc tcgtgcgagc atgtcgtccg cttcggcggg
     6721 gccccaggtg ccggccgggt actgcgccgg ctcgccgctg cggtcccaga actcctcgac
     6781 ggggtcgagg atccgccagg actcctccac ctcctcggtc cgcgggaaga ggttggcgtc
     6841 ccccagcagc acgtcgagga tgaggcgttc gtacgcctcg gggctggact ccgtgaacga
     6901 ctccccgtag gcgaagtcca tcgtcacgtc gcgcagctcc atcgatgtac ccggcacctt
     6961 ggagccgaac cgcaccgtga cgccctcgtc cggctggacc cggatgacga gcgcgttctc
     7021 gccgagctcc tccgtggcgc tggagtcgaa cggcgagtgc ggggcgcgct ggaagacgac
     7081 cgcgatctcg gtgacgcggc ggccgagccg cttgccggtg cgcagataga acgggacgcc
     7141 cgcccagcgg cggttgtcga tccccagctt gatcgcggcg taggtgtcgg tcctcgagtc
     7201 gggggcgatg ccctcctcct gaaggtagcc gaggaccttc tcgccgccct gccagcccgc
     7261 cgcgtactgc gcgcgcacgg tggaccgggc caggtcggcg ggcaccttga cggccttgaa
     7321 gaccttcagc ttctcggtga cgagggcgtc cgcgtcgaag gaggcgggct cctccatcgc
     7381 ggtcagcgcc agcagctgga ggaggtggtt ctggatcacg tcacgggcgg cgccgatgcc
     7441 gtcgtagtac ccggcgcggc cgccgatacc gatgtcctcg gccatcgtga tctgcacatg
     7501 gtcgacgtac gaccggttcc agatcggctc gaacagcgtg ttcgcgaacc gcagcgccag
     7561 gatgttctgg accgtctcct tgcccaggta gtggtcgatc cggaagacct cgtcgggcgc
     7621 gaacacctcg tgcacgatct cgttgaggtc gcaggcgctc gtcaggtcgt ggccgaacgg
     7681 cttctcgatc accgcccggc gccaggaccc ctcgggggcg tccgacagcc cgtggtcctt
     7741 cagctgctgg acgacctcgg gaaagaactt cggcggcacg gagagataga acgcgaagtt
     7801 cccgcccgtg ccctgagacc tgtcgaggtc ctcgacggtg gccttcagct gctcgaaggc
     7861 ggcgttgtcg ccgaagtcgc cctggacgaa gcgcatcccc tccgagagct ggttccagac
     7921 ctcctcgcgg aagggggtgc gggcgtgctc cctgacggcc tggcggacct cctcggcgaa
     7981 gtcctggtcc tgccattccc ggcgggcgaa gccgacgagc gagaagcccg ggggcagcag
     8041 cccccggttc gccaggtcgt agacggcggg catgagcttc ttgcgcgaca ggtcaccggt
     8101 gaccccgaag atcaccagtc cggaggggcc ggcgatacgg ggcagccgcc ggtcgagcgg
     8161 gtccctcagc gggttggccc agccgctccc ctgcgaccgc cgccgcgccc tgtgctgcga
     8221 cctgctctgc gacccgttct gtgacatgcg gtcaggcctc cctgcgccga cggcgttcgg
     8281 atgcgtcctc gtcccgagga tcgcatcttc cgctgatctc acggcggcac acacacccgt
     8341 cggtgcgagt tccgtgcgag gggattgacc gccgatttgc caggctccag gttcccagaa
     8401 aattgcgcat aaaacttccg aaagtttcga aacctgtgcc gccacatcac cgcggaggtg
     8461 cggcacttcg agggccggat ctggcagttg ggacgagcac cgccctgtac gagcttggtg
     8521 aagcagctgc gccgggaggg cgtgccggtc gacggcgtcg gcctccaggg gcacttcgcc
     8581 gtccagtacg gcttcccctc cgacgtggcg gccaacctga agcggttcga cgacctcggt
     8641 atggagagcg ccgtcacgga gggccgacgt gcggatgccg atgcccgcgg acaacatcaa
     8701 gctccaggcg caggcccggg gttacagcgt gctgctccaa gcctgcctgg tcaggtactc
     8761 gccggtgccc ggcaccttcg agggagcaca aagaaccccc gggagcagct cgctcccggg
     8821 ggttctcgcg gctgccgcgg tcaggcggtg accggggcca cctcggtgtc gcagtgcagc
     8881 acgcggccgt ggccgcatcc gcgctccggg ccggtcaggc gcagccgtac cgtgtgccgg
     8941 acgtcctgcg gcgcgctgga ggccgcgaac cggagctcca ggtcgcccgg ttcgacgatc
     9001 cgacggccgc cgacgcccgt gaacgaggcg aggtcggtgt ggaagcggaa acgaacccgt
     9061 gccgcctcac ccgccgcgag gggcacccgg gcgtagccga tcagctgtgc ctggggccgg
     9121 gtggtctggg cgaccgggtc gtgcagatag agctggacga cttccgcgcc gtcgcggtcc
     9181 ccggtgttgc gtacgacgac ctcgacgtcc gcggagccgt cggtcgggat cccggccggc
     9241 gcggccgcgc cggcctccca ggcgaacgtg gtgtaggaga gcccgtggcc gaaggggtac
     9301 agcggggtcg ggtcgagatt gctcaccccg cccgcgagcc ccagcggcgg ctggaggtac
     9361 gtccagggct ggccgcccgg cccgtgcgga accccgaccg gcagtcggcc ggacgggttg
     9421 acgcgcccgg agaggacgcc ggccagtgcg ggaccgccct cctcgccggg gaagaacgcc
     9481 tgcaccacgg ccgcaagccg gtccgcccag cggcccaggg cgtacggccg gcccgtcacc
     9541 agcacggcca ccaccggcgt gccggtggcc agcagggcgt ccagcagccg ggcctggacg
     9601 cccgggagcg agaggtcggc cgcgtcgcag ccctcgccgg aggtgccgcg gccgaagagc
     9661 ccggcccggt cgccgaggac ggccacgcag acgtcggcgt cggccgccag ccgcaccgcg
     9721 tcggcgatgc cggaagtgtc cggcccgtcg acgtcgcagc cggcggcgtg gcggacggcc
     9781 gcgtcgggga actcgtcggt cagcgccgcc agcacggtgg ggatgtcgac gccgaggggc
     9841 acgtcggggt gcgagacgcc tacatgactg gggaaggagt agcagccgag catggccagc
     9901 ggatcgtcgg cccggggacc gacgaccgcg atgcggcggg cgtcgcggag cgggagggcg
     9961 ccgcccgcgt tggcgagcag tacgcaggac tgctccgcca tcagccgggc ggttgcacgg
    10021 ttggcgggcg cgtccaggtc gacggtgccg cgcacggacg ccgggtcgtc cgatccgccg
    10081 agcacgtcgg gcagcggcga ccagtcgggg tcgagcagcc ccagttcgca cttctggagc
    10141 agcacccggc gcagtgcgcg gtccacagcg gcctcgggca cggtaccgtc ccgcacggcg
    10201 tcgacgagtg cgtcgccgt
//
