LOCUS       NZ_CP102865            20237 bp    DNA     circular CON 26-JAN-2024
DEFINITION  Paenibacillus polymyxa strain S3 chromosome, complete genome.
ACCESSION   NZ_CP102865
VERSION     NZ_CP102865.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5740272)
  AUTHORS   Yang,S., Jin,D., Li,H., Jiang,L., Cui,J., Huang,W., Rang,J., Li,Y.
            and Xia,L.
  TITLE     Screening of new Paenibacillus polymyxa S3 and its disease
            resistance of grass carp (Ctenopharyngodon idellus)
  JOURNAL   J Fish Dis 46 (1), 17-29 (2023)
   PUBMED   36097971
REFERENCE   2  (bases 1 to 5740272)
  AUTHORS   Yang,S., Jin,D., Li,H., Jiang,L., Cui,J., Huang,W., Rang,J. and
            Xia,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-AUG-2022) State Key Laboratory of Developmental
            Biology of Freshwater Fish, College of Life Science, Hunan Normal
            University, Yuelu, Changsha, Hunan 410006, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 16-JUL-2021
            Assembly Method                   :: SOAPdenovo v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 164.83x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/24/2024 02:01:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,183
            CDSs (total)                      :: 5,026
            Genes (coding)                    :: 4,956
            CDSs (with protein)               :: 4,956
            Genes (RNA)                       :: 157
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 111
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 70
            CDSs (without protein)            :: 70
            Pseudo Genes (ambiguous residues) :: 0 of 70
            Pseudo Genes (frameshifted)       :: 32 of 70
            Pseudo Genes (incomplete)         :: 48 of 70
            Pseudo Genes (internal stop)      :: 10 of 70
            Pseudo Genes (multiple problems)  :: 17 of 70
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:25:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4094839
            Orig. end                         :: 4115076
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hunan Normal University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20237
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="proteusin"
                     /region_number="11"
                     /rules="(PoyD or TIGR03793)"
                     /tool="antismash"
     cand_cluster    1..20237
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PoyD or TIGR03793)"
                     /kind="single"
                     /product="proteusin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20237
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10237](-)"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10237)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
     misc_feature    284..300
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.33"
                     /tool="antismash"
     misc_feature    complement(385..398)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.55"
                     /tool="antismash"
     misc_feature    complement(1068..1079)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     gene            1221..1400
                     /locus_tag="NWS42_RS18560"
     CDS             1221..1400
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369715.1"
                     /locus_tag="NWS42_RS18560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="WP_013369715.1"
                     /transl_table=11
                     /translation="MIRDDILRQQLENARQKLYILQAKHGFNHASVLKQSVIMDNLINQ
                     YNHLFYIKEKKPTA"
     misc_feature    1251..1269
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.6"
                     /tool="antismash"
     gene            complement(1468..2370)
                     /locus_tag="NWS42_RS18565"
     CDS             complement(1468..2370)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686326.1"
                     /locus_tag="NWS42_RS18565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EamA family transporter"
                     /protein_id="WP_016821372.1"
                     /transl_table=11
                     /translation="MNKVIAHHSESNRIYYTSTILALLIWSTSFIATKAAYTTFPPLTL
                     GLSRFIIASIVLGIVLLIKKEHVKVKPKDLATISFSGVLGITLYFSMENIGVSLTTASN
                     AALIVASYPAITSLLEFILYKVKLSKYKVCGIALAMIGVYFLTSVGESSDGKNQLIGNL
                     ILIGTGFAWAFYTFMTRKVVDKYPPVTLSFYQTVAGSIFFIPLALLEKDSWQAPTTGSF
                     MLLMYLGVFCSVIAFLLYNYGLIKLSPSSSVSLMNLVPIFGVLFSVLLLHETITWRQII
                     GGLVVIIGVLMSAHQTNRT"
     gene            2531..3391
                     /locus_tag="NWS42_RS18570"
     CDS             2531..3391
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369717.1"
                     /locus_tag="NWS42_RS18570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TrmB family transcriptional regulator"
                     /protein_id="WP_013369717.1"
                     /transl_table=11
                     /translation="MKSKPNILEILRDLNFSEYEAKAYVTLLESSPLSGYAVSLNSGVP
                     RSKIYEVLSGMVNRGDIMVSQENTPLYVPLPPHELIAQRKRKAEQIFNVAQESLEQYTA
                     SFQNRENIWNISGYEAIINRINEGVKGAKHRILLEIWKEDAEVFRDALEQAAQQGIEVI
                     LVAYGDLNFDFATVYRHDMSEEITSEIGGRWIVLSVDDREVVAGILSLGDDSRAAWTLH
                     PGLVMPITEVIIHDIYIMEILYEFREELEAKFGPNLIHLRNKFAMGPNGKGYYVPLTEK
                     SIKRV"
     gene            complement(3477..5099)
                     /locus_tag="NWS42_RS18575"
     CDS             complement(3477..5099)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429103.1"
                     /locus_tag="NWS42_RS18575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1593 domain-containing protein"
                     /protein_id="WP_263559958.1"
                     /transl_table=11
                     /translation="MRKRKGLSIFVLAMICILIISGCSDKSPAVVKDESAAPTEQPAGN
                     KVENKATKARTVITTDGEVDDMNSVIRFLLYSNEMDLSGIVLTSSVYHYAGDEKAGIKP
                     FRWTGTQWVTDMIDAYGEIYPNLIKHAEGYPKPEYIKSVTKIGNISNKGEMDKETEGSN
                     FLKTLFLDNDKRDLYVQTWGGTNTTARALKSIEDEYKNTDQWETIQKKVSDKLVLYIIL
                     DQDDSYNNYIAKNWPDIRIINDQSNFWHFAYAWKMHTEEVNSKLHGEWNFKNIKDGHGK
                     LLNMYALMGDGNIIKGELDEEQRGSEAYLKKNPQYDKYDFISEGDSPSFFYLIDNGLRS
                     MENPTYGGWGGRFGVVNDKLFRNTVLDYDVHTKKFEAEYSLMRWFDDIQNDFAARADWA
                     IASDYKDANHNPTLTIKEGLDLTASPGENITLHAEGTDPDGDALTYKWWRYFEADTYED
                     SKVKPAQVKPEMLGDMQLGLHRELAKGEKVNTIDLQGSNTNTASFTVPADAKSGDTIHI
                     IAEVQDNGKHSLKHYQRVIVTVK"
     gene            complement(5336..6418)
                     /locus_tag="NWS42_RS18580"
     CDS             complement(5336..6418)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046417 - chorismate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369718.1"
                     /locus_tag="NWS42_RS18580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional 3-deoxy-7-phosphoheptulonate
                     synthase/chorismate mutase"
                     /protein_id="WP_013369718.1"
                     /transl_table=11
                     /translation="MSTNENSLELLREQLDATNLQLLELLSQRAELAGQLGKLKEAQGV
                     PDFDPVREQQMLDKLIAANRGPFDDATIRQLFKNIFKASLNYQKEEHKKHLIVSRKNQP
                     DSTVIKVKDTLVGGKASIMVAGPCSVESYQQTREVGAALKEAGVPILRGGAFKPRTSPY
                     DFQGLGIEGLQILKRVGDEFGLATISEIVDPRHLEEAIPYIDIIQIGARNMHNFELLKA
                     AGETRTPVLLKRGLAATMEEFLHAAEYIVSRGNTQVMLIERGIRTYEKWTRNTLDISAV
                     PILKKESHLPVLVDVTHSTGRKDILAPCAKAALAAGADGIMVEVHPNPAVALSDAQQQL
                     NIPEFHNFLSEVKESGLFKA"
     gene            complement(6876..7055)
                     /locus_tag="NWS42_RS18585"
     CDS             complement(6876..7055)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821368.1"
                     /locus_tag="NWS42_RS18585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_016821368.1"
                     /transl_table=11
                     /translation="MYKDPMSQADMEYKRYKALNPVEEDDRRTADKTHTDDTLAEDNPR
                     GVASAKPEPRDQAR"
     misc_feature    7113..7124
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.16"
                     /tool="antismash"
     gene            complement(7148..7408)
                     /locus_tag="NWS42_RS18590"
     CDS             complement(7148..7408)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369720.1"
                     /locus_tag="NWS42_RS18590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_013369720.1"
                     /transl_table=11
                     /translation="MANRDNQKTELQDHDFEPSLQNAETNWENLIEGPDTPLEDVPDAD
                     ELTPNSPVDPSAPAEFLHGTDLLNGTDGDEEEQLDSDDILD"
     gene            7592..7879
                     /locus_tag="NWS42_RS18595"
     CDS             7592..7879
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369721.1"
                     /locus_tag="NWS42_RS18595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_016821367.1"
                     /transl_table=11
                     /translation="MEWYMFGPMISRIRVGQKASTPGYSRTVIRRPDGLYWTDGGQAGK
                     IVEIRDYLFSDIWTIYEDEECEPWIGLREQMERREQEMIINQYEDFTNND"
     gene            8012..9901
                     /locus_tag="NWS42_RS18600"
     CDS             8012..9901
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686330.1"
                     /locus_tag="NWS42_RS18600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_263561024.1"
                     /transl_table=11
                     /translation="MRHVPKAVAALLAVIVILLSLDHIGYAAKMTPEREYKIPSWDMRW
                     GAEDEDGSLDEVNDHSKVWMHIEDDTQLLKQPGNRGTAWIRIKLPSLNDETPAVLFENI
                     YGRHITLYKDGTNFYESYRGYNYENNRILIPLKPEDSGKTLYIWTESSKNRLGIIGNVM
                     TGDYRDLLGNLVRMDVLDIVLGSTFIFIALVLLICSFFLFRPSMAMWLSLSAIVLSIGL
                     MIVTYSPFLYTFYRGYGKLYLQLFDVALFILLPSLAFFFEQNINSILLIRKFRKLLTAY
                     SLFCFIIMIVNLGAQERLNDVYYFFSVIVLGILLVALMVLLVFASVRMALKGDHEAIIL
                     STGFAFFAVITIAELSWFFIRDGHYNMFLWKWGVFGFVLALIVILGRRLAEKHKQVVRY
                     SRELEMFNNELQRSEKMEIISDLAASVAHEVRNPLQVTRGFLQLMSKQEDGKNKDYLHI
                     ALEELDRASAIITDFLTFAKPEFDHTKTLTILDEFKHIEGIISPMANLQGGKISLDIPQ
                     EIKVRGNSSKFKQAFINIIKNSIEALREQGHIHIWAYVDNGEAVIHIRDNGEGMDAQTL
                     SRLGEPYFSNKTKGTGLGMMVTFRIIETMNGKISFTSAKGVGTEATIRFPVAG"
     gene            complement(10001..10237)
                     /locus_tag="NWS42_RS18605"
     CDS             complement(10001..10237)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proteusin: TIGR03793"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429107.1"
                     /locus_tag="NWS42_RS18605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP leader peptide family RiPP precursor"
                     /protein_id="WP_016821365.1"
                     /sec_met_domain="TIGR03793 (E-value: 1e-19, bitscore: 68.2,
                     seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATEVLQTQVIQKAWEDASFREKLMADPKSAIRDVLGVVIPDHIQ
                     IKTVEETSDQFYLVIPPNPSGVLATSQKPRSMW"
     gene            complement(10313..11248)
                     /locus_tag="NWS42_RS18610"
     CDS             complement(10313..11248)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369724.1"
                     /locus_tag="NWS42_RS18610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_029514408.1"
                     /transl_table=11
                     /translation="MEWYFAYKEELEKVFRQAEERTATFQAPFQQEGLDYLARFNPLRE
                     DSTRNYICYLLPFWLQELTGLPPETCRKLSLGNVFVMAHYLIQDDVMDTAADNRKTQLA
                     LSQLFYTECQNIYQELFPATSPFWTYARTYVDEWAVSVVSEGAADYFQGDRNKVALKAS
                     PLKMAGTGALLLADHADLIEIVTAMTDLALLVLQMSDDWADWTEDLMEHSYNCLLSHIS
                     AERKKPYCEGLGPQEIQEAIYVRGALASYVNIANQAVQELETMEPTIHGLYRFAHSIAT
                     ELSEEAAEIEGGRSHLRRGGLDYWLSKNMK"
     misc_feature    11320..11332
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            11440..11913
                     /locus_tag="NWS42_RS18615"
     CDS             11440..11913
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821363.1"
                     /locus_tag="NWS42_RS18615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_016821363.1"
                     /transl_table=11
                     /translation="MKKQWKLTAAILYGGVMMYGTASAGASGIESGNPLQALTPNDSVQ
                     GEAHQWNIDPQDDHGHGHVHRHRHGKGPGGLNHHLNEKVARLLGITPVQLEKELGQGKS
                     LAEVAKSKGIREDQLIDKLKNEMTVDLKRLVNRKGPITFDRKSGTSNEAQLKR"
     gene            complement(12011..12517)
                     /locus_tag="NWS42_RS18620"
     CDS             complement(12011..12517)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821362.1"
                     /locus_tag="NWS42_RS18620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_263559959.1"
                     /transl_table=11
                     /translation="MKSHVLIYDGYVSFEIMLATYFMKTKGDIVTIGVTKEPVISYEDF
                     KVMPAVALDEVCAEDIQLLIIPGGDNTQLKTNKQLLALIHTLNNDHKVIATICSANELL
                     ELAGVSPKNHVSHPSGLEIHKNIISAKPNKYVDFAIEIGKVMNIYTDDEDFNETIDFFK
                     LFKDS"
     misc_feature    complement(12687..12696)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            complement(12893..13153)
                     /locus_tag="NWS42_RS18625"
     CDS             complement(12893..13153)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015947.4"
                     /locus_tag="NWS42_RS18625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AbrB/MazE/SpoVT family DNA-binding
                     domain-containing protein"
                     /protein_id="WP_225164852.1"
                     /transl_table=11
                     /translation="MKNTGMTRPLDTLGRIVIPKELRNSMGIQAGESLEFYLDVETGLL
                     SMRKYIGVCCHLCYSVQDLSYFRDSFLCKKCIHDLKGNSVI"
     misc_feature    complement(13201..13210)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            13355..14752
                     /locus_tag="NWS42_RS18630"
     CDS             13355..14752
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821361.1"
                     /locus_tag="NWS42_RS18630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_016821361.1"
                     /transl_table=11
                     /translation="MEITPTIQAEVQTYLKRKSLTMTEFGHTIDLNVGTVSGIVTGNRS
                     MSVHQLDSITAGMNLPPDYFYERYIEECIEECPLNWKKISPFLYRCIELGRLDCLQRVV
                     ILLLDNPNYLPSLFEVAENVYKDGYSEAAAYLYKKVAESEKQQHSERLAICQYRLFQIK
                     VGQDRAVNLQAAIEFAPFVDRLDEIEQLDALKDLANVYRSLSMWDKVYEFAHQMGQLGQ
                     LQYHLVHNSKRKGTEPRKKLSRPLFVYIVYAELLCANACDAKGNHDQALEHIRGYADLN
                     WVKEQDSDTLYWKRKYQQWAKINTYVNRLMSGDISVLPDYVEHIAAEKEILAELLNVLE
                     VANRYNVDVDHILRRFESQIAAYQESPSSDMYTQQVLTEEYVRFWYKIAKYSLNKGRYT
                     YGFKCLLIAFEKAVTINHVLLIANCFGLFLHFKTNAAPKTQAQFHSIYEEVWEKNDQKD
                     GFLLGGN"
     misc_feature    complement(14946..14960)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.68"
                     /tool="antismash"
     gene            14977..15231
                     /locus_tag="NWS42_RS18635"
     CDS             14977..15231
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369731.1"
                     /locus_tag="NWS42_RS18635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="WP_016821360.1"
                     /transl_table=11
                     /translation="MNKDEKVTLIQQMEHARQHMHDLYAEYGLGHACVLEQSMLLDELI
                     NQFNRMFQTRKQPHQVLDQILNNDDGMLSSSPHSYYAKL"
     gene            complement(15434..16657)
                     /locus_tag="NWS42_RS18640"
     CDS             complement(15434..16657)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369732.1"
                     /locus_tag="NWS42_RS18640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyltransferase"
                     /protein_id="WP_017426378.1"
                     /transl_table=11
                     /translation="MSKPRIAEWTELRGLAYLAVVLQHCIGEYIYRSDIQQPDSVMLAM
                     LYHLTRFGTPTFVFLSAALLFYNGNKPIGYSRYIGRRFRDIYVPFLCWTVVYWVCTQNW
                     STAQWGNLSFYKGMFEEMIIPVSGYHLWFVVMIFQFYIWFPLFAKATEQIRTFLRRYST
                     KKRKQLVLAVMLIAAAAYALLLQWSYYDMSAWSAWLPSFGQTLLDYRTYNFVMYFFYFM
                     LGAVCAYMTDTWRGLAQQTLPWNVFVFIGLFMLMGHTMLIQSGDTINLNISTYLKPSTF
                     VLIVSQLLLLYGLLLHLQKDQRSEPFRRMLNWIGRYSFGGYLAHALVLSFISFYTRPLA
                     LGDHHFTATLITFVVVASASLGISWLFAHLPGGNWIVGSKGRQRLNWRLHFQFLSSKRS
                     SKSTQELS"
     gene            16864..17871
                     /locus_tag="NWS42_RS18645"
     CDS             16864..17871
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429118.1"
                     /locus_tag="NWS42_RS18645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_017426379.1"
                     /transl_table=11
                     /translation="MKKTLLVYMLLIAAFALYVFRYEQSERLNGAWEEKGLRGSIGETY
                     MMITFQSGLEYWKSGLKGFEDAGDALGVTVEYRGATRYDAQEQMTIIEQAIARKPAGIA
                     ISAIDPHSLIPVINKALDADIPVVLFDAGAPGSRAYTFLGTDNYKAGVTAAEKMAELLG
                     REGQVAVLTLPGQQNHEERSRGFRDTIQRQYPAMKVVEVVDGRADVMVSRDESLRLMKA
                     YPKLAGIFVTEATGGTGVGEAALSQKGSHPLKIISFDTNKATLDMIRDGTISATIAQGT
                     WNMGYWSLQYLFHLHHHLTIPAPSSSGDNTPLPVRVDTGISVVTRANVDDYYAK"
     misc_feature    17876..17890
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.23"
                     /tool="antismash"
     gene            17906..19906
                     /locus_tag="NWS42_RS18650"
     CDS             17906..19906
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369734.1"
                     /locus_tag="NWS42_RS18650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_038978144.1"
                     /transl_table=11
                     /translation="MMPRLRLRNMPLRYQLMVLFLLFGIVPSLGLGLLVNWTVERIIER
                     QVENHTMQLIGKVNEALDTKMENLQNMTYLIAFNPEVGEFWKGRTLADGHAGHTSSVMP
                     ENQAEQAQKPLLNQAPGSKQVVSSVQEQDTLYEMKQFLQGFTTLYPEIAGILIVNEKGD
                     YISNEMYARSTRSLTEEDWYTQAAQHAGIFTVLGQPSHRNVTTHVRYKDSEIVSVVRSV
                     TDSETGHVLGVIMIDLKLRAVSQAARDVTLGKSGYVMVTDAKGRSVYMPDMPLIERIPS
                     QWFGPEDSGMFTREAGGRELLFMFQASEFTGWRTVGVFPARESTLEVRQIQFYVVCFVF
                     IVCLFGLTASLRLSSSIAQPIFRLMSYMRTAETGDLTVRQWSERGDEIGMLGRSFNRML
                     EQIRRLMSLSELRERQKRDAELRSLQEHIKPHFLYNTLDTIHWMARKNGADDVSDMVGA
                     LSRLFRLGLSKGDDFIPLRSEIEHISSYMQIQQTRYRDRLRWELNVPDGLKDLFVLKLM
                     LQPVVENAIYHGIKARRGPGTICVEAKAEDGKLLLTVRDDGAGMTAERLRELREWLEIP
                     LEAMEGKRKQKEVRTNGRSYGMLNVQARIRLSFGEEYGITLDSKEGTGTCVTITHPLLL
                     DMAQLKKPYDKGEGQDDEIQGNRQRDNGESD"
ORIGIN
        1 tgaatacgga attgggggtt aacgatcaac tggaattatg gtcaggaatt gcctttggag
       61 ttactttttt agcgagcgcg ctgattgccc cgttttgggg ctcgctggca gataagtatg
      121 gacgtaagcc gatgctgatt cgttcagggt ttagcctggc tgtattgtat ctggtatgtg
      181 ctttagtgac agacccatat gtatttgtag gagttcgctt gtttcaagga cttctctccg
      241 gatttattcc tgcggcgatt gcgctggtcg gaacgggctc gcctgaagaa aaaacgggct
      301 atgcccttgg cattatggcg actgctggag cgactggcag cattataggt ccgctgatcg
      361 gtggtgtggt gagccattat tatggcaatc gaaatgcctt ttttttctca gcggctcttg
      421 ttctggtatc tgcgttcatc gcgacatttg gcgctagaga ggatagcttc aagggcacca
      481 gtacccgctc gcatgttcgg gatgatatca aagaggctat tgctaatcgg ccattatact
      541 ttttgcttat tctagctgga ttaagtacct tttctgttat gatcttggaa ccgttaatta
      601 cggtgtatgt gcttgaaatg ggtgtggacc gtagccatgc gtctttaagt tccgggattg
      661 tattctcagc tgtaggcatc gcggcagtgc tgatggctcc ccgatggggc cggattggag
      721 ggaaaatcgg ctttgcccaa gtgttgctga ttgggctgat cggttcgggg attgggaaca
      781 tcttgcagtt ttttgtaacc aactttgttg gttttggtgc gcttcggttt ggatatggat
      841 tgttttatgc gtctgtcatg ccggcgatta atgccatgac tgtggaagtc accaagccgg
      901 agtttcgtgg acgagccttt agcctgaatc aatcagctac ccaactcgcg acgatggcgg
      961 ggccgctgat tggcggcatg cttggtagct ggatgcccat tcgctggatc ttcgtattaa
     1021 acggtggcat cttgctggtt gcagcgttgt tgctatgggc gaagggaaaa aacgttttcc
     1081 cgatttcagc ccaaaataaa gcaacggatc agaatattca ttctgccgga taggccaatt
     1141 agataattat cccaaaccct tatttttagt atattattca taacccttta cactgatcat
     1201 atgacaggga gggatatatt atgataagag acgacatttt gcgtcaacag cttgagaatg
     1261 cccgtcaaaa gctgtatatt ttacaagcaa aacatggctt taatcatgcc agtgtgctca
     1321 aacagtctgt aattatggat aacctcatca atcaatataa ccaccttttt tatataaaag
     1381 aaaaaaagcc gactgcatag atataaccaa ctgggcgaga tcttttaaaa aggccactcg
     1441 cccttgtatt gtagagctgc aatatcttta ggtacggtta gtttgatgcg cactcatcaa
     1501 gacccctata ataacgacca agccgccaat gatttggcgc catgtaatcg tttcgtgcaa
     1561 tagtaagaca gagaacaaca ccccaaatat cggaaccaaa ttcattaaag aaacggaact
     1621 gctcggtgac agcttgatta atccgtaatt ataaagcaaa aatgcgataa cggagcagaa
     1681 cacacccaga tacatgagca acataaacga tcccgttgtc ggagcctgcc agctatcctt
     1741 ttctaatagg gctaacggta tgaaaaagat actacctgca acggtttgat aaaaagataa
     1801 cgtcaccggc ggatatttgt ccacaacctt acgcgtcatg aaagtgtaaa acgcccacgc
     1861 aaatccggta ccaatcaata ttaaatttcc gatgagttga ttcttaccat ccgagctttc
     1921 gccaacggag gttaagaaat ataccccgat catggccagt gctatgccgc agactttata
     1981 tttggataat ttgactttat acaaaataaa ctcaagcagc gatgtaattg caggatacga
     2041 tgcgacaatt aatgctgcgt tggaagcggt cgtcaggcta acccctatat tctccattga
     2101 aaaataaaga gtgattccca aaaccccact aaacgaaatc gtagccaaat cctttggctt
     2161 tactttgaca tgttcttttt tgatcagcag aacgatacct agtacgatgg aagctatgat
     2221 aaatctggat agacccaagg taagaggagg gaacgtcgta taggctgctt tggtggcaat
     2281 aaacgatgtg ctccagatca atagggctag aatcgtagaa gtatagtaaa tccggttgct
     2341 ttcgctgtga tgagctatga ctttgttcaa gttatatcct ccctgagttc atcccctatg
     2401 aaatatgata gtgatagtag ctactatagt tactactatg aaaatgctac taaaaagata
     2461 atttgtatat cagtttttgt caaggggaag tgatatagta aggaagaaca tgaattgagg
     2521 agaagacgtc atgaaatcaa aaccaaacat attagaaatt ctacgtgatt tgaattttag
     2581 tgaatatgaa gccaaggctt atgtgacctt attggaaagc tctccacttt cgggatatgc
     2641 cgtttcattg aactctggag taccgagatc caagatttac gaggttttat cgggaatggt
     2701 caaccgtggg gacatcatgg taagtcaaga aaatacacct ctatatgtgc cgcttcctcc
     2761 acatgaattg attgcccaga gaaagcgcaa agcagagcag attttcaacg tggcgcaaga
     2821 gagtttggag cagtacacag catcgtttca aaacagagag aacatttgga atatttcggg
     2881 gtatgaagcc attatcaatc gcattaatga aggcgtgaag ggagcaaaac accgaatttt
     2941 actggaaatt tggaaagagg atgccgaggt gttccgggat gccttagagc aagctgctca
     3001 gcaaggaatt gaggtgatcc ttgtagcata tggtgatctt aactttgatt ttgctactgt
     3061 ttaccgccat gatatgagtg aggagattac gtccgaaatc ggtggtcgat ggattgtgct
     3121 tagcgtggat gaccgggagg ttgtagctgg catactttca cttggtgatg acagccgtgc
     3181 tgcatggacg ctacacccgg gtcttgtaat gccgattacg gaagtgatta ttcatgatat
     3241 ttatatcatg gaaatcctat atgagttccg tgaagaatta gaggcaaaat tcggccctaa
     3301 tctaatccat cttcgcaata aattcgccat gggtccgaat ggaaagggat attatgttcc
     3361 tttgactgaa aaaagtatta aacgtgtata gagattgtcc gaggtgcgat acgcaaaaat
     3421 aaacaggccc atggagtatg attccatgag cctaatttat tgagtgctgt cttctgttat
     3481 tttacggtta caatcacacg ctgataatgt ttcaaagaat gtttaccatt gtcctgtact
     3541 tctgcaatga tatgaattgt atccccagac ttcgcatctg ccggaactgt gaaacttgca
     3601 gtatttgtgt tgctaccttg caggtcaatc gtgtttactt tctcgccttt agctaattct
     3661 cggtgaagcc caagctgcat atcacccagc atttcaggtt taacttgcgc gggtttgacc
     3721 ttagaatctt cataggtgtc agcttcgaaa tatctccacc atttataggt caatgcatca
     3781 ccgtcaggat ctgttccttc tgcatgtaga gttatgttct cccctggact agccgttaga
     3841 tctaatcctt ctttaatggt caatgttgga ttatggttgg catctttata gtcggaagca
     3901 atagcccaat ctgcacgggc agcaaagtca ttttgaatat catcaaacca acgcatcaga
     3961 gagtactctg cttcgaattt tttcgtatgc acatcataat ctaacaccgt atttctaaat
     4021 aatttatcgt taacgacacc aaaacgacct ccccagccac cataggttgg gttttccatg
     4081 ctccgtaatc cgttatcaat taaatagaag aaggatggag aatctccttc ggaaataaag
     4141 tcatacttgt cgtattgtgg atttttcttc aagtaggctt cactgcctct ttgttcttca
     4201 tccaattcac ctttgatgat attgccatcg cccatcaagg catacatatt cagcagcttg
     4261 ccatgaccat ctttaatatt tttgaagttc cattccccgt gtaacttgct gtttacttct
     4321 tccgtgtgca ttttccaagc ataagcgaaa tgccagaagt tagattggtc attgataatt
     4381 ctgatgtcag gccaattttt ggcgatgtaa ttattgtagc tatcgtcctg gtccaaaatg
     4441 atgtacagaa cgagtttatc acttactttt ttctgaatcg tttcccattg atctgtattt
     4501 ttatattcat cttcaatgga tttcagagct ctggctgtgg tattggttcc tccccaggtt
     4561 tgtacataca gatctctttt gtcattgtct aggaaaagtg ttttcaggaa attcgagcct
     4621 tccgtttcct tgtccatttc acctttgttt gaaatatttc cgatcttggt aacgctttta
     4681 atatattcag gttttggata cccttcagca tgtttgatta ggttgggata aatctctcca
     4741 taggcatcaa tcatatccgt tacccattgg gttccggtcc atctgaatgg cttgatgccg
     4801 gccttttcat cacctgcata atgatatacg gagctagtca gtacaatccc ggacaaatcc
     4861 atttcgttag agtagagaag aaagcgtatg actgagttca tatcatctac ttctccgtca
     4921 gtagtaataa ccgttctagc cttggtcgct ttattttcca ctttatttcc cgctggttgt
     4981 tctgttggag cagcgctttc atcctttacg acggctggcg acttatcact gcaaccactg
     5041 atgattaaaa tacatatcat agctaacaca aaaatgctta acccttttct ttttctcatt
     5101 tctgttcccc tctctgaacg ttcctatgat gattttttag gattataacc atgcaggtat
     5161 tgttattatt caagaattgg gcataaaaaa aacctaaaca tatatatgtc tcaacaaaag
     5221 tcgagcatat atacatttag gttttgcctg catgatcagt cacaatcctg attagattct
     5281 acatcataat ctgacaaaat gaaagcggtt tatgactctt agcacaaaat tagttttacg
     5341 ctttgaataa accggattct ttaacttcag acaggaagtt gtggaattca gggatgttca
     5401 gctgttgctg agcatcggac aaagcgactg ccgggttcgg gtgaacttct accatgatgc
     5461 cgtcggcacc agctgccagg gcagccttgg cacaaggggc caggatgtct ttacgtcctg
     5521 tagagtgagt tacgtccacc aatacaggca gatggctttc ctttttcaaa atcggaacag
     5581 cggaaatatc cagcgtgtta cgtgtccatt tttcatacgt acgaataccg cgttcaatca
     5641 acatgacttg tgtattacca cgggatacga tgtactcagc agcatgaagg aactcttcca
     5701 tggtggcagc caatccgcgt ttgagcagaa ccggagttct cgtttcaccc gcagctttca
     5761 gcaattcaaa gttgtgcatg ttgcgcgcgc caatttgaat gatatcgatg taagggatcg
     5821 cttcctccaa atgtcttgga tcgacgatct cactgattgt agccagcccg aactcgtcgc
     5881 caacgcgttt gagaatttgc aggccttcaa tacccagtcc ttggaaatca tacggagatg
     5941 tacgtggttt gaacgcacca ccacgcagaa tcggcacacc ggcttccttg agagccgcac
     6001 ctacctcgcg cgtttgttgg tagctttcca ccgagcaagg acctgcaacc atgatggagg
     6061 ctttgccacc taccagtgtg tctttaacct tgataaccgt gctatccggc tgatttttgc
     6121 ggctgacaat caaatgtttt ttgtgttctt ctttttgata gttcagagaa gccttgaaaa
     6181 tatttttgaa caactggcga attgtagcat cgtcgaaagg tccacgatta gctgcaatca
     6241 gcttgtccag catttgttgc tcgcgcactg gatcaaagtc aggcactcct tgagcttctt
     6301 tcaattttcc aagctgtccc gccagttcag cgcgttggga cagcagctcc agcaattgca
     6361 agtttgtagc atcgagctgt tcccgcaaca gctccaaaga attttcattg gttgacatac
     6421 agtacaccct tcccgaattt aaattgtttt ttctttcagc ccttggactt tttgcagaaa
     6481 ataacacaaa aaggcactcg tcgcaaggga cgaatgccgt ggtaccaccc taattacaga
     6541 agtatacatg caagtcgtca acgtcattca atcgacggca gtaacctctg agcttgatgc
     6601 ccgtaacggg ggcttccgga aacctctact gcgaccaaag gaatgaatcc ttctgtcgtc
     6661 ggttcaaggc tcgactcggg agtgaatttc aacgcgggat agcggtacgc tctcagcaat
     6721 acgtaccttt ctgtgggaat ccgatgacgc ttacttgtct ccgtctatgt ctttgttcat
     6781 ggtattcaaa agatttgacc ttattttaaa caaagtggat gcagaaggca agccctgatt
     6841 tccgattcta gtttttgcat tccctatctg ttctttcatc ttgcttgatc cctgggttcg
     6901 ggcttcgctg atgcgactcc tcgtgggtta tcttcggcta aggtatcatc cgtatgagtc
     6961 ttgtccgcag tcctgcggtc atcctcttct acaggattca aggctttata gcgtttgtac
     7021 tccatatcag cctgagacat cggatcttta tacataggag attggtcaac tcctttcggt
     7081 gtatatactt cattacccgc atagcaggat gagaaatcgc tttcttatat cctattatat
     7141 gcagtaatta atccagaata tcgtcactgt ccagttgctc ttcttcatcc ccgtctgtac
     7201 cgttcagcaa atctgtacca tgcaggaatt cagcaggcgc agagggatca acaggactat
     7261 tcggtgttag ttcatcggca tcaggcacgt cctccagagg agtatccggc ccctcaatca
     7321 gattctccca gtttgtttct gcattttgca gggaaggctc aaaatcatga tcctgtagct
     7381 cagtcttttg attgtcgcga tttgccatct aactcagctc ctttactttt tgttgcttat
     7441 ttcgacctta cccaaaccgc agaatggcta aacttagagt tagtgtgtct gtaaaaagtt
     7501 aaaatcatgc gaatagagat atgctctttc tcaattagcg tttttttggt aactgctgtg
     7561 atatgataaa gaggagttgg agggatatga attggaatgg tacatgtttg gtccgatgat
     7621 tagccgaatc cgagtaggtc aaaaggcgtc tactccaggc tattcgcgta ccgttattcg
     7681 gcgtccggat ggtttatatt ggacagacgg cggacaggcc ggaaaaatag tagaaatacg
     7741 cgattattta ttctccgata tttggacgat ctatgaggat gaagaatgtg aaccttggat
     7801 agggcttaga gagcagatgg agcgacgcga acaggaaatg atcattaatc aatatgaaga
     7861 ttttacaaat aatgattaaa aagaacatga tacccttatt atgaagaagg tatgaacatc
     7921 atcgtataga ataatataat ttcaggaaga taaaaatgtt aaaacatata caaatttgta
     7981 aatcctacta cgtaactttg aggtgcttaa tatgaggcat gtgcccaaag ctgtcgccgc
     8041 tctgctagcg gtcattgtga tactattgtc gctggaccac attggctatg cggccaaaat
     8101 gaccccggaa agggagtata agataccctc ctgggatatg agatggggag cagaagacga
     8161 ggatggctct ttagatgagg taaatgatca cagtaaggtc tggatgcata ttgaagatga
     8221 tacacagcta ctcaagcagc caggcaatag aggcaccgcc tggattcgta ttaagctacc
     8281 ttcgttaaat gatgaaacac cagcggtgct ttttgaaaat atttatggca ggcacattac
     8341 gctgtataag gatggtacca atttttatga atcgtaccgt ggctataatt atgagaataa
     8401 tcgtattctg attccgctga agccagaaga cagtggtaaa acattataca tatggacgga
     8461 aagcagcaaa aatagactgg gcattatcgg aaatgtgatg actggtgatt atcgtgactt
     8521 gttgggaaac ttggtcagaa tggatgtctt ggatattgta ctaggcagta catttatctt
     8581 tatcgccctg gtgctattga tttgctcgtt tttcctgttc cgtccaagta tggcgatgtg
     8641 gttgtcccta agtgcgattg tattgtctat cggtctgatg attgtaacgt attcaccgtt
     8701 tttatatacg ttctatcgcg gctatggcaa gctgtattta caactttttg atgtggcgct
     8761 atttattctg ctgccttcat tagccttctt ttttgagcaa aatatcaatt ctattttact
     8821 gattcggaaa ttcagaaaat tgttaaccgc ctactctttg ttctgcttca tcatcatgat
     8881 tgtgaattta ggagcacagg agcgactcaa cgatgtatat tatttcttta gtgtaatcgt
     8941 cctcggtata ttgctcgtag ctttgatggt acttttggta tttgcttcgg ttcgcatggc
     9001 gcttaaggga gaccacgaag cgatcatttt atcgacaggc tttgcatttt ttgcagtcat
     9061 cactatcgca gaactcagct ggttctttat ccgggacgga cactacaata tgtttttatg
     9121 gaaatggggc gtgttcggtt ttgtcctggc attgattgtg atcttgggca gaaggctggc
     9181 ggaaaagcac aagcaggtgg ttcggtattc cagagaactg gagatgttca ataatgagct
     9241 tcaacgttca gagaaaatgg agattattag cgatttggct gcatctgtag ctcatgaagt
     9301 gcgcaatccg cttcaggtta cacgtggatt tcttcagttg atgagcaagc aggaggatgg
     9361 taaaaacaaa gactatctgc atatcgctct ggaggagctg gatcgagcgt ccgcgattat
     9421 taccgatttt ctgacttttg ccaagccaga gtttgaccat accaaaacgt tgaccatatt
     9481 ggatgagttc aagcatattg aaggaattat cagtccaatg gcaaatttgc aaggtggcaa
     9541 aatttcgctg gatattcccc aggaaattaa agtgcgcggg aattcctcta aattcaagca
     9601 ggcatttatc aatattatca aaaatagtat tgaagcgctg cgagaacagg gacatattca
     9661 tatatgggct tatgtggaca atggagaagc agtcattcat attcgggata atggtgaagg
     9721 gatggatgct cagaccttat ccagactagg tgagccttat ttttcgaata agactaaagg
     9781 cacgggtttg gggatgatgg tgacatttcg gattattgaa acgatgaatg gtaaaatatc
     9841 ttttacaagt gcaaaagggg tgggaacaga agcgaccatc cgcttccccg tagccggata
     9901 acatccggct tttttgcttt cggagaaaac ggagggaagc ttgctgagcc cacccgcctg
     9961 agattaagaa gtatagatta aataagctac aagtgccaat ctaccacatc gagcgaggct
    10021 tctgggatgt agcaagcaca cctgaagggt ttggagggat tactagatag aactggtcag
    10081 acgtttcctc taccgttttg atttggatat gatcggggat cacgactcct aacacatcac
    10141 gaattgcaga tttgggatct gccatcagtt tttctctgaa actggcatcc tcccaagctt
    10201 tttgaatgac ttgtgtttga agaacttcag tagccatcaa aaatcaccct ctcattcgat
    10261 tggttatatt tacctagtca gtataccacg taagactcag aaaaatctag cattacttca
    10321 tatttttgga gagccaataa tcaagcccgc ctcttcgcaa atgtgagcgt ccgccttcaa
    10381 tttctgctgc ctcttcgctg agttcggttg cgatggaatg tgcgaaccta tacaggccgt
    10441 ggatagtagg ctccatcgtc tctagctcct gaacggcttg attcgcaatg ttcacatagc
    10501 tagcgagtgc gcctcgcaca taaatcgctt cctgaatttc ttgtggtcct agtccttcac
    10561 agtacggctt cttccgttcg gcgctaatat gggacaatag gcagttatag ctatgctcca
    10621 tcaaatcctc tgtccaatct gcccaatcat ccgacatttg gagcacgagc agggccaaat
    10681 ccgtcatcgc tgtaacgatc tcgatcaggt cagcatggtc tgcgagcagt agagcacccg
    10741 ttccggccat ttttaatgga ctggctttca gtgcgacctt atttctgtca ccttgaaaat
    10801 agtctgctgc tccttcggac accacactaa cggcccattc gtccacatac gtccgggcat
    10861 atgtccaaaa aggggaggtt gccggaaaaa gctcctgata aatgttttgg cactcggtat
    10921 agaaaagctg gcttaaggca agttgcgttt tacggttgtc tgctgctgtg tccatcacgt
    10981 cgtcttggat taaataatga gccatgacga acacgttgcc gagtgacagc ttgcgacatg
    11041 tttcgggagg cagtccggtg agttcctgca gccaaaatgg aagcaaatag catatgtaat
    11101 tacgcgtact gtcttcacgc aacggattaa accgtgccag gtagtctaac ccctcttgct
    11161 gaaagggagc ctgaaatgtg gccgtccgtt cctccgcttg acgaaatacc ttttccaatt
    11221 cttctttgta tgcaaaatac cactccatgg ccatcacccg catctcttat aaatgttttt
    11281 gtagcgactt ctagttgtta cccgccattg tacaacagat tgcaattttc aagaatttgt
    11341 tatttttaaa taaggaatgt tgtgaaaaac atataaaatg aataaaaaaa gctgaaagag
    11401 aaaatataga tgaaaaagga tgaaaggagg ggccacaaca tgaaaaaaca atggaaattg
    11461 accgctgcta tcctatatgg aggagtgatg atgtatggta ctgcgagtgc aggagcatcc
    11521 ggtattgaat cgggtaatcc gttgcaagct ctcactccca acgattctgt ccaaggagaa
    11581 gcccaccagt ggaatattga tccacaggat gaccacgggc atggacatgt gcatagacat
    11641 agacacggca aagggccggg cggcttgaat caccatctca acgagaaagt agctaggctg
    11701 ctgggtatca cccctgtcca gttagagaaa gagctggggc aagggaaatc gttggccgag
    11761 gtagctaaaa gcaaaggcat tcgcgaggat caacttattg ataaattgaa gaatgaaatg
    11821 actgtggatt tgaagcggct tgtaaatcgt aaaggtccga ttaccttcga tcgtaagtcc
    11881 gggacttcga atgaggctca attgaagcgt tagtctgaag tagaatcgtt ttacgacaaa
    11941 aaaggatggg gagaacccat cctatcctta tatttcaact tccttcataa agtgactgtt
    12001 gtgaggagaa tcagctatct ttaaaaagct taaaaaaatc aatggtttca ttaaaatctt
    12061 catcatccgt ataaatgttc atgaccttac ctatttcgat tgcaaaatct acatacttat
    12121 tcggtttagc agatatgata ttcttgtgga tctccagacc cgatggatga ctcacatgat
    12181 ttttaggaga aacacctgct agctccaata gttcattggc agaacaaatg gttgcaatca
    12241 ctttatgatc attattcagg gtatgaatga gagctagaag ttgcttattc gtctttaatt
    12301 gagtgttatc tccaccaggt ataatgagga gttgaatgtc ctccgcacac acttcatcaa
    12361 gggctaccgc aggcataact ttaaaatcct cataggaaat aacaggttct ttggttactc
    12421 caatcgtaac aatatcccct ttggttttca taaaataggt tgccagcata atttcaaaac
    12481 taacataacc atcataaatt agaacatgtg acttcattta tacacccact aacaattttt
    12541 tagtttaagt ccgttaaaag cgtctttagg aagattacat atagtcagaa tatatcatct
    12601 tgaagagttt aaatccatat tttacagaaa tatcaataag ttttggtaat ctaacttgtt
    12661 gaattttggt cagtatggat tcaaattaaa aaaataacca gtcaccttga aattaacagc
    12721 gactggttat tgagttttgc tcggatgcga gtgaagtgaa acctacaata gcttttaagc
    12781 tgggaaatac ggctatgtga cacgccaatc cattcagcat attcgccttg cttggctgtg
    12841 ggatgctcac gaatgaggct tcttagatgt tcaaccaaag ttgtgatgac gatcaaatga
    12901 cgctgtttcc tttcaaatcg tgtatgcatt ttttacataa aaatgaatct ctgaaatagc
    12961 ttaaatcctg aaccgaatag cataaatggc agcaaacgcc gatatatttc cgcatactta
    13021 acaatcctgt ttcaacatcc aagtaaaatt ccaaagactc gccagcttga attcccatag
    13081 agtttcgcaa ttccttagga ataacaatcc ggcctaacgt gtccaaggga cgtgtcatac
    13141 ctgtattttt caagtgacct tctccttatc ataataatct atcaaccaat aatctcctaa
    13201 taaaaaaata aaaatctata aaataaaagt atttatcgat gttccaaaag atggtattat
    13261 catgaatgaa aaacaataag tatactatta gtttcaaaac tatatgaatt attgaaatgg
    13321 gaatctatga agatgctgaa agggtggttt atccatggaa atcacaccta cgatacaggc
    13381 agaagttcaa acctatctaa aacgcaaaag cttaaccatg accgagtttg gtcacacgat
    13441 cgatttgaat gtaggtacag ttagtggtat tgtgacgggc aatcgatcta tgtcggttca
    13501 ccaactggat agtattactg cgggaatgaa tttaccaccg gattattttt acgaacgcta
    13561 tattgaagaa tgcattgaag aatgtccgct caactggaaa aaaatcagcc cgttcctgta
    13621 ccgatgcatt gagctagggc gattggactg cttgcagcga gttgtcattc tattattgga
    13681 taaccctaat tatctgccat cgctctttga agtcgccgaa aatgtgtaca aagacggtta
    13741 cagcgaagca gccgcatacc tgtacaaaaa ggtagctgag agcgagaagc aacagcattc
    13801 agaacgattg gcaatctgcc agtatcgctt gttccaaatc aaagtcggac aggatcgggc
    13861 agtaaacctt caggctgcta ttgaattcgc cccttttgtg gatcgcttag atgagataga
    13921 gcaactggat gctttaaaag atttggcgaa tgtctataga tcattaagca tgtgggataa
    13981 ggtgtatgaa ttcgcacatc aaatgggtca gttaggacaa ctccaatatc atctggttca
    14041 caattccaag cgaaaaggaa cagagccacg aaaaaagcta agcagaccat tgtttgtata
    14101 catagtttat gccgaattgt tgtgtgctaa cgcttgtgat gccaaaggca accatgacca
    14161 agcattagag catattcgtg gttatgctga tttaaattgg gtaaaagagc aggactctga
    14221 tacgctttat tggaaacgca agtatcaaca gtgggcgaaa attaatactt atgttaacag
    14281 gcttatgtct ggtgatatta gtgttctgcc agattacgta gaacatatag ctgccgaaaa
    14341 agagatttta gccgagctat tgaatgtcct tgaagtggct aatcgctata atgtagatgt
    14401 agatcatatt ctccgacggt ttgaatcgca aattgcagcg tatcaggagt caccttcttc
    14461 tgacatgtac acacaacaag tgttaacaga agaatacgta aggttttggt acaagatagc
    14521 caagtacagc ctaaataaag gcagatatac atatggtttc aaatgtttat taatcgcctt
    14581 tgaaaaagct gttacaatta accatgtatt actcattgcc aattgttttg gattatttct
    14641 tcatttcaaa acaaatgcgg cacctaaaac acaagctcag ttccattcta tttatgagga
    14701 ggtgtgggag aaaaatgatc aaaaagatgg ctttttgctt ggcggtaact agtttcttac
    14761 tggtattcac agtaccagct caaactgcaa atttaagcca tggcacgatc caagttcaag
    14821 gacacattgg tggatcttga cgagtactaa ttcattttat tggccagctt attgctggtc
    14881 tctttttgta ttattttgta attttttgct tcaaaattga tcttggccta tttgtacatc
    14941 ccttcttaaa atgaaattca tgaggaggta tgtaggatga acaaggatga aaaggtaacg
    15001 ttaattcaac aaatggaaca tgccagacaa cacatgcatg atctttacgc agagtatggc
    15061 ctaggacatg cctgtgtact ggagcagtct atgcttttgg atgaactgat taatcagttc
    15121 aaccgtatgt ttcagaccag gaagcagcct caccaagttt tggaccagat ccttaacaac
    15181 gacgatggta tgctgagttc atccccccat tcctattatg caaaactgtg atttctccca
    15241 cgtaatgctt ataattattc aatataatga cttattttaa aataaaatac atatccatgt
    15301 cataaaatgt taatcagttt ggaacatgat tcatcacact tagacagcaa aaaagcagag
    15361 ctcaatacgt gagccctgcg aaagtccttg atgttgcttg aaatccctat gctgatacgc
    15421 tgaggcaaaa tgactagcta agctcctgtg tgcttttgga agaacgtttg gaggaaagga
    15481 actgaaaatg aagccgccag ttcaatcgct gtctgccttt ggagccaaca atccagttgc
    15541 cgccaggcag atgggcaaag agccagctga taccgagaga agcacttgcc acgacgacaa
    15601 acgtaatgag cgtagctgta aaatgatgat cccctagggc aagcggacgg gtgtaaaagg
    15661 atatgaagga cagcacgagc gcatgggcca gatatcctcc gaaggaatag cgtccgatcc
    15721 agtttagcat acgacgaaac ggctcggaac gctggtcttt ttgcaaatga agtagcagcc
    15781 catacaacaa aagcaactgc gagacaatca gtacgaaggt gcttggcttc agataggtag
    15841 aaatattgag attgatcgta tcgcccgact ggatcagcat cgtatgaccc atgagcatga
    15901 acagaccaat aaaaacaaat acattccatg gcaacgtctg ctgggccaat ccccgccagg
    15961 tgtccgtcat ataggcgcat actgcgccca gcataaaata gaaaaagtac ataacaaagt
    16021 tataagtgcg gtaatctaac agggtctgcc caaaggatgg caaccaagcg ctccatgcag
    16081 acatgtcata gtaggaccat tgtaacagca acgcataagc cgcagcagca atcagcatga
    16141 cagccaaaac aagctgcttg cgctttttgg tgctataacg acgtagaaac gttcgaatct
    16201 gctcggttgc ttttgcaaat aaaggaaacc aaatataaaa ctgaaagatc atgaccacaa
    16261 accatagatg atatccgctg acagggatga tcatttcctc gaacatacct ttgtaaaagg
    16321 ataaatttcc ccactgcgcg gttgaccagt tctgagtaca tacccaataa acaaccgtcc
    16381 agcagagaaa aggaacataa atatctcgaa accgtctgcc aatataacgg gaatagccaa
    16441 tcggtttgtt accattataa aataacagcg ccgcagacag gaaaacgaac gtcggtgtgc
    16501 caaaacgtgt caaatggtac agcatcgcga gcataacgga atccggctgt tggatgtcgc
    16561 tgcgataaat atattcgcca atgcaatgct gaagcacgac agcgaggtag gcaagacccc
    16621 gtagttctgt ccactctgcg atacgcggct tgctcatcca tatcactcct tttcctcaag
    16681 attcgcacat gtttttccta gcacaattgt aggtattgta ccgtaggaac attagtgcag
    16741 gattaacgct acctgaaagt atggagagtg aagtggttcc aatttaatat gattgcgttt
    16801 acaatctaaa taaaaacaaa gcaaattaaa tttaaggatg cgcataggaa gaggagagga
    16861 aggatgaaga aaacgctgct ggtgtacatg ctgttgattg cggcctttgc tctctatgtg
    16921 ttcagatatg aacaatccga gcggttgaat ggagcttggg aggaaaaagg gctgcgaggc
    16981 agcatcggag aaacgtatat gatgattacg ttccagtccg gtttggaata ttggaaaagc
    17041 gggctcaaag gcttcgagga tgctggggat gccttggggg taacggtgga gtaccggggg
    17101 gcgacccggt atgatgcaca ggagcagatg accatcattg agcaggcgat tgcccgtaaa
    17161 cccgcaggca ttgccatatc agcgattgat ccacactccc tgatcccggt cattaataag
    17221 gcgctggatg cggacattcc tgtcgtgctg tttgacgctg gagcgccggg gagccgggcg
    17281 tatacatttt tgggcacgga taattataag gcgggtgtga ccgctgcgga aaaaatggct
    17341 gagctgttgg gacgtgaagg ccaagtcgct gttctgacac tgccggggca gcaaaatcat
    17401 gaggaacgct cgcgcggctt tcgcgatacc attcagcggc agtatcctgc catgaaggtg
    17461 gtggaagtgg tagatggtcg tgctgacgtg atggtgtcca gggatgaatc gctaaggttg
    17521 atgaaggctt atccgaaact ggcgggtatt tttgtgaccg aagccaccgg aggaacaggt
    17581 gtgggtgagg cggcactgag ccaaaaaggc agtcatccgc taaaaattat ttcttttgat
    17641 acgaataaag cgacactgga tatgattcgt gatgggacca tctcggcaac gattgcccaa
    17701 gggacatgga atatgggcta ttggtcactt caatatctgt tccatctgca tcatcatttg
    17761 acgattcctg caccttcttc gtctggagat aacaccccgc tccccgtgcg ggtggatact
    17821 gggatttccg tcgtcacccg agcgaatgta gatgattatt atgcaaaata aatattggaa
    17881 gcgcatccac ttagggatgc atcaaatgat gccgaggtta cgcttgcgca atatgccttt
    17941 acgctatcag ctcatggtgc tgttcttgct gtttggcatc gtgccttcac tgggactagg
    18001 cctgctggtg aattggacgg tggaacggat tattgagcgg caggtggaaa accatacgat
    18061 gcagttaatt ggcaaggtga acgaagcact ggataccaaa atggaaaatt tacagaacat
    18121 gacgtatctg attgcgttta atcctgaagt tggggagttt tggaaagggc ggacgctggc
    18181 tgatggtcac gcgggtcata cgagtagtgt aatgccagaa aatcaggcgg agcaagcaca
    18241 gaagcctctc cttaaccagg ctcccggctc caagcaggtt gtaagttccg tacaggagca
    18301 ggataccttg tatgaaatga agcaattttt gcagggtttt accacgttat atcctgaaat
    18361 tgccgggatt ctgatcgtga acgaaaaagg agattatatc agcaatgaaa tgtatgctcg
    18421 aagcacacgc agtctgacgg aagaagactg gtacacacag gcggcgcagc atgcagggat
    18481 attcactgtg ctgggacagc caagtcaccg taatgtgacc actcatgtcc ggtacaagga
    18541 cagtgaaatt gtctctgtcg tccgttcggt cacggattcg gagacaggac atgtactggg
    18601 tgtaattatg attgatctca agctgcgggc tgtgtcgcaa gctgccagag atgtaacctt
    18661 gggcaaaagc gggtatgtca tggtgacaga tgccaaggga cgcagtgtat atatgccaga
    18721 tatgcctttg attgagcgca ttccgtcgca atggttcggg ccagaggata gcgggatgtt
    18781 tacccgtgaa gccggaggca gggaattgct gttcatgttc caggcttccg agttcacggg
    18841 ctggagaacc gtgggagtat tcccggcacg cgaatctaca ctggaagtgc ggcaaattca
    18901 gttctacgtt gtctgttttg ttttcattgt atgtctgttt ggcttaacgg catccttgcg
    18961 attgtccagt tctatcgcgc agccaatttt ccggcttatg tcttatatgc gtacagcaga
    19021 gacgggggat cttacggttc gccaatggag tgagcgcggg gatgaaatcg gaatgctggg
    19081 ccggagcttt aaccggatgc tggagcaaat ccgccgtctc atgtcgctta gcgaactgag
    19141 ggaacgacaa aaacgggatg ccgaactacg cagtcttcaa gagcatatta agccgcattt
    19201 tctatacaat acgctagata ccattcattg gatggcccga aaaaatggag cagacgacgt
    19261 atccgatatg gtgggggcgt tatcgagatt gttccgcctt ggactgagca aaggggatga
    19321 ctttattccg ctgcgctctg agattgagca tatctcaagc tatatgcaaa tccagcaaac
    19381 ccgttatcgt gaccgacttc gctgggaatt aaatgtaccc gacgggctga aggatctgtt
    19441 tgtgttgaag cttatgcttc agcctgtggt ggaaaatgcg atttaccacg gcattaaggc
    19501 cagacgtggt ccaggcacga tttgcgtaga agctaaagcc gaggacggca agctgctgct
    19561 gacggtacgt gacgacggtg cagggatgac ggcagagcgt ctgcgtgagc tgcgtgaatg
    19621 gctggaaata ccgctggagg cgatggaagg aaaacggaaa caaaaggaag ttcgtacaaa
    19681 tggcagaagc tacggcatgc tgaatgtaca agcgcgtatc cgattgtctt ttggcgagga
    19741 atatggaatt acattggaca gtaaggaagg gacaggtacc tgcgttacaa tcactcatcc
    19801 gttgctgctg gatatggcgc aactgaagaa gccttatgac aaaggagagg gtcaggatga
    19861 cgaaatccaa gggaacagac aacgcgacaa cggcgagtct gattgaccaa gccataccag
    19921 aagtgacgat agggacggcc cgacgttatc aagtattgat cgcagatgat gagccgatca
    19981 tccgtgaggg gattcgggac tgcctagact ggacggctct gggcatggag gttgtagcag
    20041 aggcagagga cggtgaagaa gcgctggaac tgattggtca gcttagcatc gacatcgtgc
    20101 tggtcgatat gaatatgcca ttcatggatg gaattgaact gattcggcag ctgcgggaag
    20161 gacgctcgga gtgccgttgc ctgatcattt ccgggcatga tgaatttgct tatgcacagg
    20221 aagctgtacg gcttggc
//
