LOCUS       NZ_CP102865            27353 bp    DNA     circular CON 26-JAN-2024
DEFINITION  Paenibacillus polymyxa strain S3 chromosome, complete genome.
ACCESSION   NZ_CP102865
VERSION     NZ_CP102865.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5740272)
  AUTHORS   Yang,S., Jin,D., Li,H., Jiang,L., Cui,J., Huang,W., Rang,J., Li,Y.
            and Xia,L.
  TITLE     Screening of new Paenibacillus polymyxa S3 and its disease
            resistance of grass carp (Ctenopharyngodon idellus)
  JOURNAL   J Fish Dis 46 (1), 17-29 (2023)
   PUBMED   36097971
REFERENCE   2  (bases 1 to 5740272)
  AUTHORS   Yang,S., Jin,D., Li,H., Jiang,L., Cui,J., Huang,W., Rang,J. and
            Xia,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-AUG-2022) State Key Laboratory of Developmental
            Biology of Freshwater Fish, College of Life Science, Hunan Normal
            University, Yuelu, Changsha, Hunan 410006, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 16-JUL-2021
            Assembly Method                   :: SOAPdenovo v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 164.83x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/24/2024 02:01:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,183
            CDSs (total)                      :: 5,026
            Genes (coding)                    :: 4,956
            CDSs (with protein)               :: 4,956
            Genes (RNA)                       :: 157
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 111
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 70
            CDSs (without protein)            :: 70
            Pseudo Genes (ambiguous residues) :: 0 of 70
            Pseudo Genes (frameshifted)       :: 32 of 70
            Pseudo Genes (incomplete)         :: 48 of 70
            Pseudo Genes (internal stop)      :: 10 of 70
            Pseudo Genes (multiple problems)  :: 17 of 70
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:25:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3868141
            Orig. end                         :: 3895494
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hunan Normal University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27353
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="9"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..27353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..24366
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14366](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14366
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    133..153
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.47"
                     /tool="antismash"
     misc_feature    complement(647..660)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.15"
                     /tool="antismash"
     gene            728..1492
                     /gene="aroD"
                     /locus_tag="NWS42_RS17760"
     CDS             728..1492
                     /EC_number="4.2.1.10"
                     /GO_function="GO:0003855 - 3-dehydroquinate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426256.1"
                     /locus_tag="NWS42_RS17760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="WP_263559912.1"
                     /transl_table=11
                     /translation="MAKIVKVKDVRIGEGAPKICVPMVGETLEQLKEEAAHLRTLDLDI
                     VEWRVDFFEHVEELEKVKAALHEIRSILANIPLVFTFRSAREGGEKEISAASYVELNRT
                     IAETGQVDMIDVELFNEEADVMMLIEAAHKHNVYVIISNHDFQKTPSKEEIVSRLRKAQ
                     ELGGDLPKIAVMPTNTADVLTLLDATRTMAEEYADRPIITMSMAGKGVVSRLTGELFGS
                     ALTFGAAKKASAPGQIPVTELREILQVLHSHS"
     gene            complement(1593..2165)
                     /locus_tag="NWS42_RS17765"
     CDS             complement(1593..2165)
                     /EC_number="2.7.1.71"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004765 - shikimate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819867.1"
                     /locus_tag="NWS42_RS17765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="shikimate kinase"
                     /protein_id="WP_016819867.1"
                     /transl_table=11
                     /translation="MQNNSEIPLKEQNIVLIGFMGVGKTTIGSHLARKLYRDFVDIDQE
                     IEQEYNMPTTEIFKTYGEKRFREIEKEHILKLCSNTRLKIISVGGGAFLQEEVKQACLA
                     SSIVFFLDLNWDSWKDRLKMLIDTRPNLQNKTLEEIEDLFRSRQDIYAVNHSKIDTDQL
                     DAEEVADYIIQTLNLGWELYEPTRGLN"
     misc_feature    2389..2409
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.85"
                     /tool="antismash"
     misc_feature    complement(2575..2590)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            2732..3424
                     /locus_tag="NWS42_RS17770"
     CDS             2732..3424
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819868.1"
                     /locus_tag="NWS42_RS17770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pectate lyase"
                     /protein_id="WP_016819868.1"
                     /transl_table=11
                     /translation="MKTNTAKVLKKGMSIALSGMLIALFVGNYSAHAAPEVVHKTILVK
                     AGEVYDGKGKTVVADPDTLGDGSQKEAQKPIFKLENNATLKNVIIAAPAADGVHVYGNG
                     TISNVTWEDVGEDALTLKEPGTVNITGGGAFHAYDKVFQINAEGTINIKNFRADDIGKL
                     VRQLGGSTFRVNMTLDNSDISNVKDSILRSDGPNSKAKITNTRYHNVKQLFKGFKSGNT
                     SESGNTKY"
     gene            3563..4600
                     /locus_tag="NWS42_RS17775"
     CDS             3563..4600
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426257.1"
                     /locus_tag="NWS42_RS17775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_029514341.1"
                     /sec_met_domain="APH (E-value: 9.1e-14, bitscore: 50.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVLLHFIQKSWVAMNLFHQYVNHDGTLNDTLVHSREILYTGTNG
                     RHVERFYVSSSESYIFKPLTNDDQKGRERWVYEHVLPALSPIYPQLLACSDTDADGGGE
                     WMVFEDLGPLHHLHADETLLQAVGLVARWHALPPGRFAGMPLRGPKPLIQEMVSELHTR
                     KPDMLELCSSLGFSKQQMQRIYAQLEHLSFSHQLVLSHGDLHPGNYALSGERLRVLDWE
                     HAHLNTPLWDVYHLIDMSHPLFPRRMTSELRIRMLDTYLEQLELLGIKGDRTAFIQEYG
                     MFAVVFSLWMLLLITNDLQRIGTELHRNSGKWSKEQLESQLDATLACLNQCTAMMDWVQ
                     VQPCK"
     misc_feature    3579..3592
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.72"
                     /tool="antismash"
     gene            4656..5654
                     /locus_tag="NWS42_RS17780"
     CDS             4656..5654
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279969.1"
                     /locus_tag="NWS42_RS17780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_019686235.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.7e-11,
                     bitscore: 41.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVGLVMRKIQFAEAQGPRIFAERLKQIGLELGVDIVFVSPERH
                     VSSHDWLPGYEHEKSDLVNYDIVLDQLHEQQIEHVIYTVSGFTYLNMFFKNSVLFPHSF
                     PDPALTGYEMMKPFYQIVDKAIVQTAFLKQEMASKFGVTDVTVIPIGFNERLVEKHFDP
                     SQVVENRVMWIGRDEENRRPDLVLEYARHNPDKDVYMVFGGERYKESMKKYDIPDNVKL
                     QFALTQDEVFALMNTAKVYWSCSKFDTFAMPLTEALAMGKIVVKPEHPCYGHISSTHSF
                     SGNEKNWFELVNMAAASPRRVSAENQTYAMEQFSSQVMKQGYRDFFDDWLS"
     gene            complement(5728..6936)
                     /locus_tag="NWS42_RS17785"
     CDS             complement(5728..6936)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369570.1"
                     /locus_tag="NWS42_RS17785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_016819870.1"
                     /transl_table=11
                     /translation="MSTQENMTANRFPPSLLWLTLGAFAIGMTEFVIMGLLPNVAHDLH
                     VTIPQAGQLITSYALGVAIGAPVLTVLTHKVPQKKLLCLLMSIFILGNLFSVIAPNYEL
                     LIAARMATALSHGTFLGAGSLIAARLVRPDKRAGAISMVLTGLTVANIIGVPFGTFIGQ
                     QLGWRASFGAIVVIGLISLFGIIRYIPVIQQDKPSSLKQEVKSLFNPKVLLMLLTGAVG
                     CGSLFTVFTYITPMLTDISGFAEHSITWILVLFGLGVTIGNIVGGKLADWKLLPSLVAN
                     YAVLAIILAILTFTLQNKVLAVITVFIWGIAAFGIMPGIQVRIMNLAYEAPLLASTSSH
                     SALNLGNAGGAFIGGVVINQMGLPAIPWVASLITVGGLLLMLVSYMMDRKTAHTEAIAE
                     IQS"
     cand_cluster    6757..27353
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    6757..27353
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[16756:17353](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      16757..17353
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     gene            7153..8076
                     /gene="cysK"
                     /locus_tag="NWS42_RS17790"
     CDS             7153..8076
                     /EC_number="2.5.1.47"
                     /GO_function="GO:0004124 - cysteine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene="cysK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819871.1"
                     /locus_tag="NWS42_RS17790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine synthase A"
                     /protein_id="WP_016819871.1"
                     /sec_met_domain="PALP (E-value: 2.9e-69, bitscore: 231.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLKVVHRITDLIGDTPCVRLQRLTGPQDAEVYVKLEYFNPSGSV
                     KDRAAGNLIAEAEKAGHLKPGGTIIEPTSGNTGIGLAMNAAARGYRAILVMPSNMTKER
                     INILKAYGAEVVLTPAEERMPGAIRKALELGTEIEGSFIPHQFENKANPDIHRTTTAFE
                     ILEQTEGRLDVFVASSGTGGTITGTGEVLRQHLPDLRIVVVEPKGSPVLSGGKPGPHKL
                     VGTSPGFVPTVLNTEVYDEIIQVSDEDAIAITRAIAAQEGILVGPSSGATIWTAIQEAR
                     RLGAGKRVLCIAPDTGERYLSMGIFG"
     gene            complement(8222..8350)
                     /locus_tag="NWS42_RS17795"
     CDS             complement(8222..8350)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NWS42_RS17795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_016819872.1"
                     /transl_table=11
                     /translation="MAANLDDHIHTILAETTEQNGGVLLSMDGIQPEKDNEALYVL"
     gene            complement(8365..8643)
                     /locus_tag="NWS42_RS17800"
     CDS             complement(8365..8643)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NWS42_RS17800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_146169109.1"
                     /transl_table=11
                     /translation="MLPMWHGIKNTDTERNDDAWSMAYACKNPVCSYTGVSYKSGEEEL
                     LSIERSSYGYDVLDHVDQLRFKQDMTAKELTDDTTCTRHPKQAPKIC"
     gene            8842..8988
                     /locus_tag="NWS42_RS17805"
     CDS             8842..8988
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="NWS42_RS17805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_226888859.1"
                     /transl_table=11
                     /translation="MFDLDLRKSYEASELSPQASIIKTTIKVSKAVCKTLTCICTGSCS
                     NCK"
     CDS_motif       8842..8895
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MFDLDLRKSYEASELSPQ"
                     /locus_tag="NWS42_RS17805_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8896..8988
                     /prepeptide="core"
                     /locus_tag="NWS42_RS17805_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.70"
                     /molecular_weight="2943.6"
                     /monoisotopic_mass="2941.6"
                     /core_sequence="ASIIKTTIKVSKAVCKTLTCICTGSCSNCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFDLDLRKSYEASELSPQ"
                     /leader_location="[8841:8895](+)"
                     /alternative_weights="2961.6"
                     /alternative_weights="2979.6"
                     /alternative_weights="2997.7"
                     /alternative_weights="3015.7"
     gene            9055..9996
                     /locus_tag="NWS42_RS17810"
     CDS             9055..9996
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686236.1"
                     /locus_tag="NWS42_RS17810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_226888857.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.4e-22, bitscore:
                     76.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKPNIYNWHVARLTDHFSCGATVGQPLTILFIDTGVDKSHSEIQ
                     GNLVEAECKSFVPYEPCISDYVGHGTQMVSSVTGKYILKGICPFARVVVYKITDKKGIS
                     KLEWLYRALEEGIAKGYPIINVSYRTEYEVDLFEFNRFQALVDCANAQGIWVVCSAGND
                     GRDITQEYRVPANLKGVYPIGSTNKNGDISGFSNTLNDQFFAPSGDEYEINYNNDWVMV
                     AKSSFDTEDYLYEVLGFDKAYTVGIGTSIASALFSGVVASLSGELIAQGMNAGRTEMEC
                     LLRQGARLIDVQRNYYEVSLAGSIRALRQMRG"
     gene            10001..13084
                     /locus_tag="NWS42_RS17815"
     CDS             10001..13084
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686237.1"
                     /locus_tag="NWS42_RS17815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_016819875.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.1e-111,
                     bitscore: 372.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.2e-12,
                     bitscore: 43.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.4e-24, bitscore:
                     84.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENFEISENYMYRKTLLGMEHYTQIFDHEQLDDDEYLDRLVRFV
                     QQQGLIDSIYVSSPSTYAALQSLEQGRTLKSKKKRNLILSLSKFISRAICRPTPFGLFA
                     GVGISRFGKTGGAGEHVVWATPDYSLIYRLIGLFHGDADVRNELRLSVNNTSYIDHHRL
                     VISYQTLFAADQEERSTENISILKTPVIDFIMKILDKEQQTFLQLMQAIKDAFGVDDTI
                     STDFLQQLIEQGFLVSEMIPNPRDTAPLEHLIRTLKLLAAPKAAYYSDILERVGQAIQD
                     ITVAAVKREGIEAVRKLVQLILPDYQGDLVKIDVRLNQVNEILLSDSDRQSLAQIASIL
                     SMLSTYRKEDTLSDYRQQFTEKYGVYEEVPLLQLFSKTLGLGKPEEYKSHYQNGDKYRH
                     KDEGRFRQLKALIAEWQTEALVNHSDIVLDEVKIQQLSELSLENVHVSFDLYYSCMENE
                     QGEVTFYLNNRAGSLEACQSFGRFAYMFDKDSRDEIFNFVRNPKDQKAGESGAEISFYP
                     FSPKITNIMTAGPTPDQSMDMATFPENRKLDVSQLLVGVEDSGYFYLKHRETGELVFPK
                     LSSMYNTELAPYLIRFLNDINLQYQTGWSHLEEYLYDSSFTPRVTYKNIIICPKKWTLY
                     ADKQLQSEEQFLAFLEDWIIKYNIPRYVYLVELDNKLLLDLDRHHHRKLLHKEYTRNPE
                     GKAAVIMETEKELFASANRYMEECVFFCKSPMFQYLPIDRLSAQATDKSLNKVLSSSVN
                     AVYYPGSDWISLQVYYNQEMLTDLLGSAFKTFMDNSAEYFIDQVFFVQYADKEPHIRLR
                     CKMSGSVEHQRFTALNYVFDFLNTVTSSGLVSSYSVVPYRPEILRYGGAAFIEQAERLF
                     AIDSYLVSGYYAGKRSINATDQMLFCCTGLFEVVNCAYPLAEDQLKAMAAIIDPKKFRQ
                     EYREHKEALFQRIQQTRSISLPASDTGDRLWQYAAYFTAIREADDRTNYYDDIMFSIMH
                     MFCNRVFGLDREKEELALHLCYYSLEDYLQVSKYHVAY"
     aSDomain        10448..10726
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NWS42_RS17815_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.60E-14"
                     /identifier="RREFam001.1"
                     /label="NWS42_RS17815"
                     /locus_tag="NWS42_RS17815"
                     /protein_end="242"
                     /protein_start="149"
                     /score="43.9"
                     /tool="antismash"
                     /translation="LSVNNTSYIDHHRLVISYQTLFAADQEERSTENISILKTPVIDFI
                     MKILDKEQQTFLQLMQAIKDAFGVDDTISTDFLQQLIEQGFLVSEMIP"
     gene            13095..14366
                     /locus_tag="NWS42_RS17820"
     CDS             13095..14366
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426262.1"
                     /locus_tag="NWS42_RS17820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_107735013.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-49, bitscore:
                     167.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVKQVPGNLSEIVRQSAEIYKDIDTVTLLIKKHAMHDYPEMELI
                     SLASGYPGISLLLDKLDEVYPGEGWDALAFKYNQEIVRLIGNIPFHSLSLYTGLAGVIY
                     LFNECSRGSTRYTNVLSQTLDMFLSSYGEFYEETRGKLEDSLIEDSDLDLISGWTGIAA
                     ALMEVKERQDRYAGKLDAVLLKILQLITDAVGKLRHFGELPEQTIYYNLGMAHGITGAI
                     NLLAVAHLRRYPLTGLREVLEVAKTFLLGNIREWNGTLVIPNMFTPDESAETSRNPGYH
                     RDAWCYGTPGASVAMFRLGLALEDKALQQQALQLFNTVYSRPDSLRKVISPTICHGYAG
                     LLLIQHHFSRTAAIPFKNDFLHRMLSYRNTQEAVPFTDLEGSVDDPLSLDKVGLLDGCA
                     GVLLTLLTCDNENLSTWKQMLVFS"
     gene            14382..14939
                     /locus_tag="NWS42_RS17825"
     CDS             14382..14939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819877.1"
                     /locus_tag="NWS42_RS17825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5823 family protein"
                     /protein_id="WP_016819877.1"
                     /transl_table=11
                     /translation="MFILLKEIITVMVGLITDFLSFQLDAYFYIWFLVLFISSLAATLV
                     QRSEGTITYSTAECVGINVLVVVLYLVIGTILARYFASFEDQQIVAGDKIMLYKISFML
                     TSAVIIVDIILDRLKRGRKFSYSLEFLAGSAVCFLLFQLSNQTDWIGTKLSLSYIVMVA
                     IAAGVYTMAMKFLLEYENHKEK"
     misc_feature    complement(14389..14402)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.81"
                     /tool="antismash"
     gene            14954..16747
                     /locus_tag="NWS42_RS17830"
     CDS             14954..16747
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426264.1"
                     /locus_tag="NWS42_RS17830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_263559913.1"
                     /transl_table=11
                     /translation="MELNMESTAYKKIGEEKQTAHSLLELIKIARWPKLALAWSIVFTL
                     ISAAFSLVLPIITGKLVDKISAMELTIQTAAVLISLFLAGGILNAVSSLLLRYVGSKFF
                     QELRLKIWEKIIHLPVNYFDNNENGKIISRMTNDLAIVSNFLAITLPSILADVLMVTGC
                     IIMLFVLDWRLMSVLVALIPITALLIYPIGRRMNRVAIEAQDAAADFSGELSKILYNIR
                     FIKATTSEKLEMKYTREILGRIFRLNIKEGILSAVIEPIVTIIIMLALVGMFWYGSAGI
                     AAGHITTGTLVSMIFYLFTMVSPLTQLSSFFSQYQKAKGASKEIYTIYNQQDEKQEKLG
                     NVPDMKSHDQNSDILHFANVSFSYNQGQPVLSNVELTFRGGTTTAIVGPSGSGKTTIFS
                     LIEKFYLEYNGEIYYNNVYLDKIRTEEWRRKISYVMQDSDLLVGSVRDNLVYGLNRDAD
                     DHEIYAALDTVGLKEVIYQLPDGLDTFVGERGVKLSGGQKQRIQIARCLLSDHEILLFD
                     EATANLDSESEQLVHDVIKLLSKNKMTIVIAHRLSTIYKADQIIFLDKGEVTGVGTHHE
                     LMSWHDKYRDYVQFQLPTQLS"
     gene            16757..17353
                     /locus_tag="NWS42_RS17835"
     CDS             16757..17353
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686238.1"
                     /locus_tag="NWS42_RS17835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_237714596.1"
                     /sec_met_domain="AgrB (E-value: 3.1e-32, bitscore: 109.6,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALYHQLSTWIVDKYFQDEELEAEKRAYVLYYLENILAGTEKILL
                     VLVSACLLGVLAETAAMLLSYTVVRQKSFGWHARKSHHCTWVSLLTFVFVPWLLKEVEW
                     NRIFLATLCLLSIILIARYAPADTECNPLVDPKFRRACRLQAIFLSIVFVFVVIALDFY
                     PWLIFGLFLEAVVITPVFYSIMRRSYANYEQYQEY"
     gene            17474..18820
                     /locus_tag="NWS42_RS17840"
     CDS             17474..18820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819882.1"
                     /locus_tag="NWS42_RS17840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_243208234.1"
                     /transl_table=11
                     /translation="MEIEQKMITSGIYFLQYTSYLVIYHMVSGNGLSVFRMNYKLLLFL
                     VMYYFIGITALNNFGLIVYLFLFVLLALYGWLTDKYESLWVIGFYAILTIFITTLLGYF
                     ITVISYAVPYEYKNKWTAPFLTACSPPLIYLALRKLVSYLFPTPAVRLLKLYRIKLIVG
                     ASLILVLGIIGLGLIIYSECESNNPYPSRLKIVLMLIGLTSIFLMTINWLYRFLREREL
                     EKNKTEQYLQLEAYIMEIEKMYEDIRGFRHDYTNILLMLDEGIRTGDLAMIKRIYESSI
                     QPTASQLNGYSYSLDNLINLDVSELKSIITSKVLVAKKRGVDVKLEIDSGISEMYMDII
                     DLCRVISCFLDNAIDAALETCNPSINIVLIHEDDIQTVTIRNSYNHSALDGIKVNDLYK
                     RNFSTKADNRGLGLYNIAKVLRSNKYVTLDTKKEPDFFTQTLIIKRATS"
     gene            18817..19596
                     /locus_tag="NWS42_RS17845"
     CDS             18817..19596
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819883.1"
                     /locus_tag="NWS42_RS17845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_016819883.1"
                     /transl_table=11
                     /translation="MNIFILEDQFIQQRIMEKMVRKSCEELGICCSNLIVTSKPDLLLF
                     ESKACANNLYFLDIEISGCQMKGLEVAQEIRKYDMYGHIVFVTTHGHLSPITFQYKVAA
                     LDFIIKDATQDEMEKKVREVLVVAHQRKPVLDVNDWFILDNKFTKFQISFSSIYYFETT
                     GVPHKIRLVSENRTLEFYGDLKDIEAKDPRLFRCHRAFIVNLMKVESIDKSKKEIIFQT
                     NQNSGEARRIIPVSRQLLKHLLDKMGDRSLLNRPVYE"
     gene            19643..20401
                     /locus_tag="NWS42_RS17850"
     CDS             19643..20401
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426268.1"
                     /locus_tag="NWS42_RS17850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TraX family protein"
                     /protein_id="WP_016819884.1"
                     /transl_table=11
                     /translation="MEQRLSVQAEVKGIDATSLKLIAVLAMLIDHIGGLFFADFLGFQV
                     VGRITLPIMAFFVAEGYIHTRSFKKYTMRLALTGLASVVPYGLVFKDWYTSGNIMLTLL
                     MGLLAIWFYDNTTNPVLKYLAISALCVVSFLGDWSVIGVFLVLAFYVARKQQKIYNGWI
                     IAIIALMFIFGVIIIWAVPDSLSIMGINASTMNEYLYPFAIGGACIFALPLLSRYNGER
                     GKGSRAFFYLFYPLHLLALYLLKLAIEYYI"
     gene            20538..21515
                     /locus_tag="NWS42_RS17855"
     CDS             20538..21515
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426269.1"
                     /locus_tag="NWS42_RS17855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_016819885.1"
                     /transl_table=11
                     /translation="MKIMPIQKRGISNSRLVLGCMPFGGEWSHAPFTQEHVVEAERAVD
                     AAQSIGITMFDHADIYRMGKAEEIFGRILKGQPGLREQIVIQSKCGIFLPDGTLPGRFD
                     FSYDHIMESVDGILKRLSTEYLDILLLHRPDPLVEPEEVAKAFSELKTSGKVRHFGVSN
                     MNVSQIRFLERSLTEPLIANQLEMSLAHLHFIDQTVHVNQQAGTNVHFGEGLLEYCQTE
                     DIQLQAWGPLAQGRFSGGSLEGKPEHIRKTAELVQKLASEKGTTREAIVLGWLMKHPAR
                     IQPVIGSANPERIQACQDAERQSELMTREEWYQLYVSARGQALP"
     gene            complement(21673..22473)
                     /locus_tag="NWS42_RS17860"
     CDS             complement(21673..22473)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819886.1"
                     /locus_tag="NWS42_RS17860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WYL domain-containing protein"
                     /protein_id="WP_123796826.1"
                     /transl_table=11
                     /translation="MSLFEKIFNYQIVSRLDESGAFATTSQERVWLKSMLTDSAATAAF
                     TPPTLDKLWQLLADDEPLEADGSLREKAGVPAASVYHPLLRELRSILRSRSGICMTYKL
                     RNGRLHERMSGFPYKLEFSMVKKEWSLLWYNRRHRAFMSTKLSNIVTVTEDEILPEEAE
                     KFTQRILGILESRKEQGIIEIIPVYNGEMSRILYAFSCFEKEVEYDQEADTYRITLTFQ
                     ADECEYVLSKIRFLGKRVKVVQGSRLISRMKETTAKALARYEEE"
     gene            complement(22448..23773)
                     /locus_tag="NWS42_RS17865"
     CDS             complement(22448..23773)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428946.1"
                     /locus_tag="NWS42_RS17865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WYL domain-containing protein"
                     /protein_id="WP_038978103.1"
                     /transl_table=11
                     /translation="MARESFDKEIQFLRMLTLTSGAYNRQQFADRLGISVHTFDKTIRR
                     LKEIVQSVQQQLPAEQGHDFNEMLRFNYYESADPLLLFLFRAKSLKESESVRLSLLLTA
                     LQSQPMTTMELLDACCNGLPSDSALPDEKTIRSDLKYLVEVGVVRKEPGGRPYRYAVRN
                     DLVTELTDEELLDLYDFVDIMANTQLPSVQGYLLRDHLKKAMRRQLGDREMAEPFLYKY
                     HYYSRILDEAHIHPLLHAIRQRRCVNFLYFSASKRSMYGSQNTNPRFEKETEGREHTIL
                     PLQVIYDHQYGRWYVLGHVGGKGIMKFRMEGMTQLVEGKPVPEQLYADLLAVLEEKMRY
                     SWLVDTGRPVKVRVRFFNPEGAKRNFIRERVLSQGQWGTITEEESESFIYEITVNGITE
                     IKPWIRSFGSSCEVLEPQRLRKEFRQEWKELQAYYEPVRENI"
     gene            23972..25540
                     /locus_tag="NWS42_RS17870"
     CDS             23972..25540
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369575.1"
                     /locus_tag="NWS42_RS17870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="limonene hydroxylase"
                     /protein_id="WP_123796827.1"
                     /transl_table=11
                     /translation="MFGRFKNEVLYPWVGKLSIYETIKQGLDPQGRLTDDHLPDDEEYW
                     AGHTMRWVAGGLDGAFGHHGAGGDGETEKIKELAHLLSRQCRKPGMKTRRETYVRLMEE
                     NALSLIDPLLDAVREHPAIQPDRLYEEARWLAEHGAHRNVVKVGIALLGLLETEQHHEL
                     ILTLAKHDEFTLYAAVAIRNISDQANEQLYNLALQVHGWGRIHVVERLEPARQEIRDWL
                     LREGFRNNVMYEYLAYECAHKGELHTAMAVPHIDRELFDGAGDILSALLAAGGPAESID
                     DYEHAAMVIGNYLRHAKTMCTTVKHLTIIMDIADFLDEEDDSWEARYEHEWTPELRKRY
                     ASVCQQMMDDPQWVKLVEQELHHADSPHLHCAIRAARMLVLDVWPVLFDQLSKHPVKPN
                     LYFELSKTEDEQRACKLVAFAEKHLPLGEIASGPADVPGFGPEYEAHQCLGMLLQLLSS
                     YEGMGQELVATGLWSPVTSNRRAALHVLKEWPSEMWGEATIERLRCLSEAETEESIREQ
                     IWEIL"
     gene            25560..26378
                     /locus_tag="NWS42_RS17875"
     CDS             25560..26378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369576.1"
                     /locus_tag="NWS42_RS17875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_123796828.1"
                     /transl_table=11
                     /translation="MTDMKHGQGFIQPEMRETILRELRALEQEEQVRIVYACESGSRAW
                     GFPSQDSDYDVRFIYVRPIEWYLSIFDKRDVIERPISNMLDINGWDLKKALHLFRKSNP
                     PLLEWLQSPIPYLEQYSVADQIRAISPLTFSPKSCMYHYLNMARGNYRDYLQGEQVKIK
                     KYFYVLRPLLACGWIERYNSMPPIKFVDLLAEFIPVDTELYQVIEHLLERKKAGEELDM
                     EPQLSVVNDFIEQQIAYFEQKAPLLQHMEGGRDQQLDEMFRAAVNEVWKT"
     misc_feature    26892..26905
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    complement(27031..27044)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.33"
                     /tool="antismash"
ORIGIN
        1 gatgcgagta aaccgcggtt ttggcaggaa ggtgtatgtc ttattctgct tggatttacg
       61 ggacctacct tgctgtatat tgtgcagtta tggctgccta cgtttggaca acaatttatc
      121 ggcatgacgg aatcagagtc tctcagacta ttagtttatt acaatatggg ttcgctggtt
      181 tccgtgtttg tattggtcat tgtgttggga aaatgggtta aacctgttca tatcatcctt
      241 atttatcctt gtatttcctt gttggctttt ggtgcgcttc ttcttttcaa atcaggggct
      301 gccgccatta tctgtgcgag tgtcatcggg ttttcaatat cgggtgtact tcagctgacg
      361 ttaactgtaa tgagcgaatt ttttagtcaa cgaaaaggac agattaccgg gtttatttat
      421 accgcaactt cgctgtccta tacgctcatc cccgtgttta caggctttct tttgaagcat
      481 tctcaaattt ccagtgtgtt tatgctggct attatcgtga atgtgctcgg gatcgcactg
      541 gcggtgtttg ttaactttcg ttacagtgcc gtttttcctg caaaacgaga attgtctcct
      601 caaattgtac tggatacgaa ataactagcg actgaaccta atcatctgca tgcttattca
      661 gaatgcgtta tactatgaat tattgtgaat gttcgacttg aaactgtaat tggggagtga
      721 gatagatatg gcaaaaatcg taaaggtaaa agatgtacgg atcggtgaag gagcgcctaa
      781 aatatgtgtc cccatggtgg gagaaacgtt ggagcagttg aaggaagagg ctgcccattt
      841 acgtacactc gacctggata tcgtagagtg gagagtcgat tttttcgagc atgtggagga
      901 gctggaaaag gtaaaggctg ccttacatga gattcggtct attttagcca atattccact
      961 cgtatttacg ttccgtagcg cccgagaagg tggagaaaag gaaatcagtg cggcaagcta
     1021 tgtagaattg aatcgtacaa tagccgaaac gggacaagta gatatgattg atgtagagct
     1081 ttttaatgag gaagctgatg tgatgatgct gatagaagcg gcacataagc ataacgtgta
     1141 tgtgattatt tctaaccatg attttcaaaa gacgccgtcg aaggaggaaa ttgtgtcccg
     1201 gttgcgtaag gcacaggaat tgggcggcga tctgcctaaa atagcggtga tgccaaccaa
     1261 tacggccgat gtcctaacct tgttggacgc cacacgcacc atggcagaag agtatgcgga
     1321 tcggccgatt atcacgatgt cgatggcggg aaaaggtgtc gtgagccgtc tgaccggaga
     1381 gctatttggt tcagcgttga cttttggtgc tgccaagaag gcttctgcac cgggacagat
     1441 tcctgtcact gaactgagag aaatattgca ggtgctgcat agccactctt aaaagatgca
     1501 attactaccc actagcgagc aaggaattca tagtgaacac aaaaggagga ccccatgcga
     1561 taagcatgct ggggtcctcc tttttgtaat gcttaattca atccccgagt aggttcatac
     1621 aattcccaac ccagattcag tgtttgaata atatagtctg cgacttcttc cgcatccaac
     1681 tgatcggtat cgatcttgga gtgattcacc gcgtaaatgt cctgtctgga acggaaaaga
     1741 tcttcaattt cctctaacgt cttgttttgc agattagggc gggtgtcaat cagcatcttg
     1801 agccgatctt tccaggaatc ccaatttaaa tccaagaaga acacaatgga ggaagccaaa
     1861 caagcctgct tcacctcttc ctgtagaaac gcgccaccgc caacagaaat gattttaaga
     1921 cgcgtattgc tgcacaactt caaaatatgc tctttttcaa tctcacggaa acgcttctct
     1981 ccgtaagttt tgaaaatttc tgttgtaggc atgttgtact cttgttcaat ctcctgatca
     2041 atatccacga aatcgcgata cagcttgcgc gctagatggg aaccgatcgt tgttttgccc
     2101 acgcccataa agccgatgag cacaatattt tgttctttta atggaatctc actattgttt
     2161 tgcacataac cactcttttc tcaccagtaa tgttgagatg taacgcttca aagcactaaa
     2221 tacattatac gttcatcaac cgtgtcattc aatagtatag agcacatcag caatgaggta
     2281 tacgataaaa gagactctga ttaccaatgg agtgataaac agcatgtaaa cgagatgagg
     2341 tattcaagtg ttatttaatg cgtaaatgga agaaaaacaa acttgtacaa gtataaaaga
     2401 ggcaatattg tgtacttaat tgaaaaaaag gacatatttt gccgaaaaac gtattgaaat
     2461 tattggaagt aggaatataa tagagttatg caaattgtaa atgtaatcgc tctatttaca
     2521 atttgtgatt gatttaattt ataaaaatga agctactttg aaccaaaaaa ccaagtatac
     2581 atatgcaaat agttaaatat cactttacgg acatgtatcg gtcaatgggt tcattgtacg
     2641 aaggtggtga tacggtctac gcgcttgcgc tctagtcaac gaagaattgg agataagaat
     2701 aaaaaacgat ctaggagagg gatgaattga aatgaaaaca aacacagcta aagtattgaa
     2761 aaagggcatg agtatcgctt tatccggtat gttaatcgcg ttatttgtcg gcaattactc
     2821 tgcccatgca gctccagagg tcgttcacaa gaccatactt gttaaagctg gagaagtata
     2881 cgatggtaaa ggcaagaccg tagtggctga ccccgatacc ttgggagatg gaagccagaa
     2941 agaggctcaa aagcctatct ttaagctaga aaataatgca acgctgaaaa atgtgatcat
     3001 cgctgcgcct gctgcggatg gtgtgcatgt atatggcaat ggcaccattt ccaacgtaac
     3061 gtgggaggat gtcggtgaag atgcattgac gcttaaagaa ccaggcacgg tgaacattac
     3121 aggtggtgga gcgttccatg catatgataa agtattccaa atcaatgccg aaggcacgat
     3181 taacattaaa aactttagag ccgatgatat cggtaagctg gttcgccaac ttgggggctc
     3241 tacgtttaga gtgaatatga ctttggataa ctcggatatt tccaacgtca aggattcgat
     3301 cctgagatcg gacggtccta acagcaaagc taaaattacg aatactcgtt atcataatgt
     3361 aaaacaattg ttcaaaggtt ttaaatctgg caatacgagc gagtccggca atactaaata
     3421 ctaatcgtta gcgtaggata ggagtacgga taggaaaggg gctgtccaac aggtcgtatg
     3481 atctgatagg acatgcccct tttttggtat gttaagttaa ccctaagatg atctgggctt
     3541 cgttcagaac gaggactatg ttatgatcgt gctattacat tttatacaaa aaagttgggt
     3601 ggctatgaat ctatttcatc aatatgtgaa tcatgacggt actttaaatg atacgctggt
     3661 gcacagtcgt gaaattttat atacaggtac gaatggccga catgtggaac gtttttacgt
     3721 gtcctcctct gaaagttata tatttaaacc cctgaccaat gatgatcaga agggacggga
     3781 gagatgggtg tatgagcatg tgcttccagc attatcaccc atctatcccc aattgctagc
     3841 ttgttccgat acagacgcag atggcggagg agaatggatg gtgtttgagg atcttggtcc
     3901 gttacatcat ctacatgcag atgaaaccct attgcaagct gttggacttg tcgcaaggtg
     3961 gcatgctttg ccgccgggtc gttttgccgg gatgccattg cgtggaccga agccgctcat
     4021 ccaggagatg gtttccgagc tgcacacacg caagccagat atgttagagc tttgcagctc
     4081 actcggtttt tcgaagcagc agatgcagcg tatttatgca cagctggagc atctatcttt
     4141 ttcacaccag cttgtactgt ctcatggtga tcttcatccg ggtaactatg cgttgagtgg
     4201 ggagaggcta agggtgctgg attgggagca tgctcatcta aacacaccgc tgtgggatgt
     4261 atatcaccta atcgacatgt cgcatccgtt gttccctcga cgtatgacgt ctgaattgcg
     4321 tattcgtatg ctggacacct atctggaaca gctggagctg ttggggataa agggtgatcg
     4381 aacggcattt atacaggagt atggtatgtt tgctgtggta ttttcgctct ggatgctatt
     4441 attaatcaca aatgatttgc aaaggattgg aacggaactg catagaaata gcggcaaatg
     4501 gtcaaaagag caattagagt cccaattgga tgcaacgtta gcttgtttaa accaatgtac
     4561 agcgatgatg gattgggtac aagtccaacc atgcaagtag tggcttaagg cacagattct
     4621 atatagtcag ccaaagaagg tagggaaata aatccatgaa aaaagtcggt ttggtcatga
     4681 gaaaaataca atttgctgaa gcgcaagggc ctcgtatttt tgcagaacgt ctgaagcaga
     4741 tcggattgga actgggggta gatatcgtat ttgtatcgcc ggagcgccac gtaagtagcc
     4801 atgactggct tccaggctat gagcatgaaa agagtgacct ggtcaattat gacatcgtac
     4861 tggatcaact gcatgagcag cagattgagc acgttattta tacggtatct ggctttactt
     4921 atttgaacat gttttttaaa aacagcgtac tctttccaca tagttttcca gatccggcac
     4981 tgacaggcta tgagatgatg aagccttttt atcagattgt ggacaaggct atcgtacaga
     5041 ctgcctttct caagcaggag atggcctcga agtttggcgt aaccgatgtg acagtcatcc
     5101 cgatcggatt taatgagcgg ctggtggaaa agcattttga tccctcacaa gtggtggaga
     5161 accgggtgat gtggattggt agagatgaag aaaatcggcg tccagatctg gtgctggagt
     5221 atgcgcggca taatcctgac aaggatgtct atatggtgtt tggtggtgaa cgctacaagg
     5281 agagcatgaa gaagtacgac atcccggaca atgtaaaact tcaatttgca ttgacgcaag
     5341 acgaggtgtt tgcactgatg aacacggcga aggtgtattg gagctgctcc aaattcgata
     5401 cgttcgcaat gccgctgacc gaagcgctcg cgatggggaa gatcgtggtg aaacccgagc
     5461 acccttgcta tgggcacatc agctctacgc attctttttc aggaaatgag aaaaactggt
     5521 tcgagctggt caatatggct gcggcttcac ctcgccgggt ttctgcggag aatcagacat
     5581 acgccatgga acagttttcg agtcaggtga tgaagcaggg ataccgagac ttttttgatg
     5641 attggttaag ctgaacgacg aggcaggatg cgtggatgta gaccataaaa aagggacttt
     5701 cgctctaatg aacgaaagtc ctttttctta tgactgtatc tctgctatcg cttcagtatg
     5761 agccgtcttg cgatccatca tgtagctgac cagcatcagt agcagaccgc cgacagtaat
     5821 gagtgatgca acccatggaa tggcgggtag ccccatttgg ttaatcacga ctcctccaat
     5881 aaaagcaccg cctgcgttgc ccagattcaa tgcggaatgg ctggaggtag aggctagcaa
     5941 aggagcctca taggccagat tcatgatacg aacctgaatc cccggcatga tgccgaatgc
     6001 ggcaatcccc cagataaaga cagtgatcac ggccagtacc ttgttttgaa gcgtaaacgt
     6061 cagaatggcc agaataatgg ccagtacagc atagtttgca accaaggacg gaagcagctt
     6121 ccaatctgcg agcttgccgc caacgatgtt gccaatcgtg acgcctaggc cgaacaggac
     6181 gagaatccag gtaatgctgt gttcggcaaa gccactaata tccgtaagca tgggcgtaat
     6241 gtacgtaaag acagtgaaca agctaccaca gccaactgca cctgtcagca gcatcagcag
     6301 cacttttgga ttaaataagc tcttgacttc ttgcttgaga ctggaaggct tgtcctgctg
     6361 aatcaccgga atgtaacgaa taataccgaa gagagaaatc aagccgatca caacaatggc
     6421 tccaaaggaa gcgcgccagc cgagctgctg tccgataaag gtgccgaagg gcacgccaat
     6481 aatgttcgct accgtcaatc cggttagcac catcgagatg gcccctgccc gcttatcagg
     6541 acggaccagc cgggcagcga tcagggaacc ggcacccagg aaggttccgt gcgataacgc
     6601 agtagccata cgggccgcaa tcagaagctc gtagttagga gcaatgacgg aaaaaagatt
     6661 tcctagaatg aatatggaca tcagcagaca cagtagcttc ttttgtggaa ccttatgggt
     6721 taatacagta agcacaggtg caccaatggc tacaccaagc gcgtaactgg tgattaattg
     6781 cccggcttgc ggaatcgtaa catgaagatc atgggctaca ttgggcagaa gtcccataat
     6841 gacgaattcg gtcatgccga tggcgaaggc accaagggtt aaccatagca aggagggggg
     6901 aaagcgatta gctgtcatat tttcttgagt actcataagt ttcttgtatc ctcctgaaaa
     6961 aatagtaatg cgagtatatc attccaggcg acatctggcg acccattttg caagaatttt
     7021 acatactaag ctgataaggt ttgtgtaatt tacaaaagcg acaggttgga aggagccaat
     7081 tatgttattt tggtagtatg atatgaagat agggaatgac gttgtaagga ataatccggg
     7141 gaggatataa caatgacact taaagtggta cataggatta cggacttaat cggggatacg
     7201 ccttgtgtgc ggctgcaacg gctcacagga ccgcaggatg cggaagtata tgtgaagctg
     7261 gagtatttta atccaagcgg tagtgttaaa gatcgggccg cgggcaacct gattgccgag
     7321 gcggaaaagg cggggcatct aaagcccgga ggcaccatta ttgaaccgac cagtggcaac
     7381 acgggaattg gtcttgcgat gaatgcggca gcccgaggtt accgcgcaat tttggtgatg
     7441 ccttcgaata tgacgaagga acggatcaat attttaaaag cctatggggc tgaggtcgta
     7501 ctgacaccag cggaagaacg gatgccagga gcgattcgca aagctcttga actggggaca
     7561 gaaattgaag ggagttttat cccgcatcag tttgaaaata aagcaaatcc tgatatccat
     7621 cgtacaacca cggcatttga aattttggag cagacggagg ggcggttgga tgtgttcgtc
     7681 gcttcttcgg gaacgggagg taccattacg ggtacaggtg aagtgctgcg ccagcatttg
     7741 ccggatctgc ggattgttgt ggtcgagcct aagggttcgc ccgtactgtc cgggggaaag
     7801 cccggtccgc ataagctggt gggaacgagt ccgggctttg ttcctaccgt gctgaatacg
     7861 gaggtgtatg acgaaatcat ccaggtttcc gatgaggatg cgattgctat aacacgagca
     7921 attgctgctc aggaagggat tctcgtcggg ccctccagcg gagctacaat atggacggcc
     7981 attcaggaag ctcggcgttt gggagcaggc aaacgggtac tctgtattgc cccggatacc
     8041 ggagagcgtt atctgagcat ggggatattc ggataaaaag atgcgaatcg ggaccaaagt
     8101 gattcgactc atttatatgt aagatccagc ctcattaatc gaagtaacat aagtgaattg
     8161 gcgatatggt agattctttt tcaatggagg aacataaaca ttgaatacat tcttccctaa
     8221 ttcataagac gtacaatgct tcattatctt tttccggctg gattccatcc atagacaaga
     8281 gaacgccacc gttttgttct gtcgtttcgg ccagtatcgt atgaatatgg tcatcgagat
     8341 tggcagccat aggaacttga tatctcaaca gattttgggt gcttgtttgg gatgtcgcgt
     8401 gcatgtagtg tcatcagtca gttcctttgc agtcatgtcc tgtttgaagc gcagttggtc
     8461 cacatgatcc agcacatcgt agccatagga cgagcgctct atgctaagca actcttcttc
     8521 acctgattta tacgagacac ccgtatagga acataccgga ttcttgcaag catatgccat
     8581 gctccaagcg tcatcgttcc gctccgtgtc ggtatttttt atgccatgcc acatgggcag
     8641 caaaatgact gcaatttagg aggtttggaa tacctttcag gaataaagta taaaaaacgg
     8701 gagaattaga tatattcttt attcatcgac agcaagatat tacatacggt tactcacaat
     8761 gaacgtgatt taggggtacc actgaaatca tgtttattag aatttaattc agagaggaag
     8821 aggaaaatga aagtagatca aatgtttgac cttgatttaa gaaagagcta tgaggccagt
     8881 gagcttagcc cacaagcttc aatcatcaag acaaccatta aggtatccaa agcagtatgt
     8941 aaaactctta cctgtatctg taccggttct tgttccaatt gtaaataatt cataagcgat
     9001 tcgtaagtca ggggtagtga aatgggctac ccctacttac attatggaga ttgcatgata
     9061 aaacctaata tatacaattg gcatgtagcc cggctaaccg atcattttag ttgtggtgca
     9121 actgttggtc agccgcttac tatcctgttt attgatacag gcgtcgataa atcccactca
     9181 gagatccaag gtaatctagt tgaggcagaa tgcaagtcat ttgtacctta tgagccttgt
     9241 ataagcgatt acgtcgggca tggtacacaa atggttagct ctgttaccgg caaatatata
     9301 ttgaagggga tatgcccttt cgctcgggtt gttgtctaca aaattacgga caaaaaagga
     9361 ataagcaagc ttgaatggtt gtatagagcg ctggaagagg gtattgctaa aggatatcca
     9421 attatcaacg tcagctatcg tacagaatat gaggtcgact tattcgagtt caataggttt
     9481 caggctttgg ttgactgcgc caatgcgcaa ggcatatggg tagtctgttc cgcaggaaac
     9541 gatggacgcg atattacgca ggagtacaga gtacctgcga atttaaaggg agtataccca
     9601 attggatcaa ctaataagaa cggggatatc tccgggttca gcaatacgct caacgatcaa
     9661 ttttttgcgc cgagtggtga tgagtatgaa atcaattaca acaatgattg ggtaatggtt
     9721 gccaaatcga gcttcgacac agaggattac ttatacgaag tgctgggatt tgacaaagca
     9781 tacacagtgg gtatcggtac gagtattgcc agcgccttat tcagcggagt tgttgcctct
     9841 cttagcggag agcttatcgc gcaggggatg aatgccggac gcacagaaat ggagtgtctg
     9901 ctccgtcaag gcgcgagact gattgatgtt cagcggaatt attatgaagt aagccttgcc
     9961 ggttcaattc gtgctttaag acagatgaga ggttgattgc atgttggaga actttgaaat
    10021 ctcggaaaat tacatgtacc ggaaaacgtt gcttggcatg gagcattata cgcagatatt
    10081 tgatcatgaa caactagatg atgatgaata ccttgacaga cttgtacggt tcgttcagca
    10141 gcaggggttg atagattcca tttatgtctc cagcccctcg acctacgctg cactgcaaag
    10201 cctggaacaa ggcagaacat tgaagtccaa aaaaaagcgg aatcttatcc taagtctaag
    10261 caagttcatt tcgcgggcaa tttgtagacc aacaccgttt ggactgttcg cgggagtagg
    10321 catttcccga tttggaaaaa cgggaggcgc cggggaacat gtcgtctggg caactccgga
    10381 ttatagccta atttaccgct taatagggct tttccatggg gatgcggatg tccgcaatga
    10441 attgagactg agtgtaaata acacctctta cattgaccat cacaggctcg tcatctctta
    10501 tcagactctg tttgcagcag atcaggagga acgaagcact gaaaatatat ctattctcaa
    10561 aaccccggtc atagatttca tcatgaagat ccttgataaa gagcagcaga cttttctgca
    10621 gcttatgcaa gctataaaag acgccttcgg cgtggatgac acgatcagca cagatttttt
    10681 gcagcaattg atagaacaag gctttttagt aagtgagatg attcccaatc ctcgggatac
    10741 cgctcctctg gagcatctga tacgtacact aaagctgctt gctgctccca aggcagcata
    10801 ttactcagat attttggaga gagttggaca agccattcag gacattacag ttgctgcggt
    10861 caaacgcgaa ggcattgagg ctgtccgaaa actagtccag cttatccttc ccgattatca
    10921 gggcgacttg gtcaaaatag acgtaagact gaatcaggta aatgaaattc tattgtcgga
    10981 cagcgatagg caatcgttgg cccaaatagc ttcaatattg agcatgcttt ctacgtacag
    11041 gaaagaggat acactttccg actatcgtca gcaatttact gagaagtacg gagtatatga
    11101 agaagtgccc ttattgcagt tgttcagtaa gaccttgggg ctcggcaaac ctgaagagta
    11161 caagagccac taccagaacg gagataagta caggcacaaa gatgaaggca ggttccgaca
    11221 gcttaaggcg ctaattgcgg agtggcagac cgaagcgctt gtcaatcatt cggatatcgt
    11281 gcttgacgag gtcaaaatcc aacagctgtc tgaattgagt ctggagaatg tccatgtctc
    11341 gttcgatttg tattattcct gcatggagaa tgagcaaggt gaagttacgt tttatttaaa
    11401 caacagagcc ggatcattgg aagcgtgtca gagcttcgga agatttgcct acatgtttga
    11461 caaggatagc cgtgatgaaa tcttcaattt tgtcaggaac ccgaaggatc agaaagcagg
    11521 ggagagcggc gctgaaatct cattttaccc attcagtccc aaaataacta atattatgac
    11581 ggcaggcccg acaccagacc aatctatgga tatggccacg tttcccgaga atcggaaatt
    11641 agatgtttcc cagctgctgg taggggtgga ggattcggga tacttttatc tgaagcacag
    11701 ggaaacaggc gaactggtat ttcccaaact cagcagcatg tacaatacag agctggcgcc
    11761 ttatctgatc cggtttctga atgatattaa tctgcagtat cagaccggat ggtcccatct
    11821 ggaggagtat ctctatgatt cttcttttac accgagagta acctataaaa atatcatcat
    11881 ctgccccaaa aaatggacat tatatgcgga taaacagctc cagagcgaag aacagtttct
    11941 ggcctttctg gaggattgga tcataaagta taacattccg cgatatgtat atttggtgga
    12001 gctggacaat aagctgttgc tggatttgga tcgccatcat catcgaaagc ttttgcacaa
    12061 agaatatacc cggaatccgg aaggcaaggc ggccgttatt atggaaacgg agaaagaatt
    12121 gttcgcttcc gctaaccgat atatggagga gtgcgtattt ttttgcaaaa gcccgatgtt
    12181 tcagtacttg ccgatagaca gattgtctgc acaggctacc gataaaagct taaataaagt
    12241 gctgagttct tcggtgaatg ccgtttatta tccaggttcg gattggatat ccctgcaggt
    12301 atattacaat caggaaatgc taaccgattt gctgggcagt gcatttaaga cattcatgga
    12361 caatagcgcc gagtacttca ttgaccaggt tttttttgtc cagtatgcag ataaggagcc
    12421 gcatatcagg ctaaggtgca aaatgtcggg aagcgtagag catcagcgtt tcacggcctt
    12481 gaactatgtt tttgatttcc tgaatactgt aacctcgtcc ggattggtta gttcctattc
    12541 ggttgttcct taccggcctg aaattttgcg gtatggcggc gcagccttca ttgaacaagc
    12601 ggagaggtta tttgctatcg attcttatct agtttcaggc tattatgcag gcaagaggtc
    12661 aattaatgca accgatcaaa tgttattttg ctgtaccgga ctttttgagg ttgtgaactg
    12721 cgcgtatccg ctggcagaag atcaattgaa ggctatggct gcgattattg atccgaagaa
    12781 attcagacag gagtatcggg aacacaaaga agcgctattt caaaggattc aacagacccg
    12841 ttccatatcc ttgccagcaa gcgatacagg cgacaggttg tggcaatacg ctgcatattt
    12901 cacggctatc cgggaagctg acgacagaac caattattac gatgatatta tgttcagcat
    12961 catgcacatg ttctgcaaca gagtgttcgg cctggaccgg gaaaaggaag agcttgccct
    13021 acacctgtgc tactacagtt tggaagatta tttacaggta agcaaatacc atgttgctta
    13081 ttgaggagga gcttatggcg gtcaaacaag tcccgggaaa tttatctgaa atagtcaggc
    13141 aaagcgcaga aatctacaaa gatatagata ctgtaaccct gctaatcaag aagcacgcca
    13201 tgcatgatta ccctgaaatg gagctgatat cattggcttc aggatatccc gggatcagcc
    13261 ttcttctgga taaactagat gaagtctacc cgggggaagg gtgggatgcg cttgctttca
    13321 agtacaatca ggagattgtg cgcttaatcg gcaatatacc gttccattca ttgtcactgt
    13381 ataccggatt ggcaggtgtt atttatctgt tcaacgagtg ttcaagaggt tcaacaagat
    13441 atacgaatgt gctctcacag acgctggata tgtttcttag cagctatggg gaattctatg
    13501 aggagacaag ggggaaattg gaagactcct tgattgagga tagcgacttg gatttgattt
    13561 caggatggac ggggattgca gctgcattaa tggaggttaa ggaacgccaa gacagatacg
    13621 ctgggaagct ggatgcggtg ctccttaaga tccttcaact gattacggat gctgtaggca
    13681 agctgagaca tttcggggaa cttcccgaac agaccattta ctataatctt ggtatggcgc
    13741 acggaattac aggagccatt aatttgctgg ctgttgcaca tctccgccgc tacccgttaa
    13801 caggattgag agaagtactg gaagttgcca agacttttct actcggaaat atcagagagt
    13861 ggaacggcac ccttgtcata cctaatatgt tcacaccgga tgaatccgca gagactagtc
    13921 ggaatccagg ttatcacaga gatgcatggt gttacggcac accgggagct tctgtggcta
    13981 tgttccggct gggattggcc ctggaggaca aagcgctgca gcagcaggct ctgcaattgt
    14041 tcaataccgt ctactccaga ccagattcgc taagaaaggt aatttcaccg acgatctgtc
    14101 acggctatgc aggcttgctc ctgattcagc accatttcag ccgtacggca gccataccgt
    14161 tcaagaatga ttttttgcat cgtatgttat cataccggaa tactcaagaa gcagtaccct
    14221 ttacagacct tgagggaagc gtcgatgatc cgttatctct cgataaagta ggcctgctcg
    14281 atggatgtgc aggtgtattg ctgacactgc tgacctgtga taatgagaac ttgagtacat
    14341 ggaagcagat gctggtattt agctaaaagg aggagacggt aatgttcatt ttattaaaag
    14401 aaattattac agtcatggtg ggactgatta ccgattttct ctcttttcaa ctggatgcat
    14461 atttttatat ttggtttctg gtcctgttta tttcaagctt ggcggcgacc ctggttcaac
    14521 gaagcgaagg gactattacc tacagcacag ccgaatgtgt cggaataaat gtgctagttg
    14581 tcgtattata cctagtaatc ggtacaattt tggccagata ctttgcaagt tttgaggatc
    14641 agcagattgt tgctggagat aagattatgc tgtataaaat ttcttttatg cttacatccg
    14701 ctgtaattat agtggatatt atactagata ggttgaagag agggcggaaa ttctcctact
    14761 ctttggagtt tcttgccgga agcgccgtgt gcttcttact gtttcaatta agcaaccaaa
    14821 cggactggat aggaaccaag ctgtcgctct cctatattgt catggtagcg atagccgcag
    14881 gtgtctatac aatggcaatg aagtttttgc tagaatacga aaatcacaaa gagaaatagg
    14941 tgattaagcc ataatggaat tgaatatgga gagcacggca tataaaaaga tcggtgaaga
    15001 aaaacaaacg gcccattcct tgctggagtt aatcaaaatt gcgagatggc ccaagcttgc
    15061 acttgcttgg agcatcgtat ttacactgat ttccgccgct ttttcattag tattgccgat
    15121 cattacaggc aagcttgtcg ataagatctc agctatggag ctgacgatcc agaccgcagc
    15181 tgtgcttatt tcgctgtttc tggccggagg gattttaaac gccgtgtctt ctctgctcct
    15241 cagatatgtg gggagcaagt tttttcagga actgcgactg aaaatttggg aaaaaattat
    15301 ccatttgccg gttaattatt ttgataacaa cgagaacggc aaaatcatca gcagaatgac
    15361 gaacgacctt gctattgtaa gtaattttct ggctatcact ctgccttcta ttctggctga
    15421 tgtcctgatg gtcactggtt gcatcatcat gttatttgtg ttggattgga gattaatgag
    15481 tgtactcgtt gctctgattc ctataacggc gctactaatc tatcccattg gaagaaggat
    15541 gaatagagta gcgattgagg cacaggatgc agccgcagat ttttctggtg agttatccaa
    15601 aattctctat aacatcagat tcattaaagc gacgacgtcg gaaaagcttg aaatgaaata
    15661 tactcgggag atacttggac gtatctttcg cttgaacatc aaagagggaa tattgtcagc
    15721 tgtcattgag ccgattgtca caattatcat catgctagct ttggtaggaa tgttttggta
    15781 tggaagcgcc ggcattgccg ctggacatat cactacaggt actttggtat ccatgatctt
    15841 ttatttgttt acaatggttt cgcctctgac ccagctcagc agttttttct cgcagtatca
    15901 gaaggccaag ggagcaagta aggaaattta taccatatat aaccagcagg atgagaagca
    15961 agaaaagtta ggcaatgtgc cggacatgaa aagtcatgat cagaattcgg atatcctgca
    16021 ttttgccaat gtttctttct cgtacaacca gggccaaccg gtattatcca acgtggagtt
    16081 aaccttcaga ggcggtacca ctacagcgat cgtagggcct tccggctcgg gaaaaacaac
    16141 aatattttcc ttaatagaga aattttactt agaatataat ggagaaatct attacaataa
    16201 tgtatatctg gataagatta ggacggaaga atggcgtcgc aaaatatcct atgttatgca
    16261 ggatagtgac ttactggtag gatcagtgag agacaatctg gtatatggcc taaacagaga
    16321 cgcggatgac catgagattt atgcggctct tgatacagta ggcttgaagg aggtaattta
    16381 tcaattaccg gatggtttgg atacctttgt tggagaaagg ggagtcaaat tatcgggggg
    16441 acagaagcag cgaatccaga ttgccagatg cttgctttca gaccatgaga ttctgctgtt
    16501 tgatgaagct accgccaatc tggatagcga gtcagagcag cttgtacatg atgtaatcaa
    16561 gcttctctcc aagaataaaa tgaccattgt tatcgctcat cgtttgtcaa ccatctacaa
    16621 agcggaccag ataatctttt tggataaagg agaagtaacg ggggtaggca cgcatcacga
    16681 attaatgagt tggcatgata aatatcgtga ttatgttcaa ttccagcttc ccacacaatt
    16741 aagttaggga ggggtggtgg cgttgtatca tcaattgtca acgtggatcg ttgataaata
    16801 ctttcaagac gaagaattgg aagcggagaa gcgtgcttat gtgctttatt atctggagaa
    16861 catactggct ggcacagaaa aaatacttct tgtattggtc agtgcctgtt tgctcggtgt
    16921 attagccgaa acggctgcga tgctgctttc ctatacagtg gtccggcaaa agtcctttgg
    16981 ctggcatgct cgcaagtcgc atcattgcac ctgggtcagt ctactgacct ttgtgtttgt
    17041 tccctggctc ttaaaggaag tagaatggaa ccgcattttt ctggcgacgc tctgtctgct
    17101 ttctatcatt ctgattgcca gatacgctcc ggccgatacg gagtgcaatc cattggtaga
    17161 tccgaagttc agaagagcat gcagattaca agctatcttt ttaagtatag tgtttgtttt
    17221 cgtggtcatc gcactagatt tttatccttg gttaatattt gggctgtttc ttgaagcagt
    17281 cgtcatcaca ccagtattct attccataat gagaaggagt tatgccaatt atgaacaata
    17341 tcaagaatat taaagaacac agaaacaacc atacccagag actcaaggct aagctactgg
    17401 agcatatgag taaaagaggt gaaggaggag ggatttgttt cgggttgttc tatgaaccag
    17461 tcaacccaaa agtttggaaa ttgaacaaaa aatgattaca tccggcattt attttttgca
    17521 atacaccagc tatcttgtaa tatatcatat ggtcagcggc aatggtctaa gcgttttccg
    17581 tatgaattat aagctgctgc tgtttttagt catgtattat tttatcggaa taacagctct
    17641 gaataacttc ggactgattg tttacctatt tctatttgtg ctactggcat tatacgggtg
    17701 gttgaccgac aaatatgaat ccttgtgggt cataggcttc tacgccatcc ttaccatctt
    17761 tattacgaca ctgctgggtt atttcataac ggtaatcagc tatgcggttc cttatgaata
    17821 taaaaacaaa tggacggcgc ccttcctaac cgcttgttca cctccgctga tctacttagc
    17881 gctccgaaag cttgtgtctt atttgtttcc tactccggcg gtcaggcttt tgaagctata
    17941 tcggattaag cttatcgtcg gagcttcttt aatcttagtc ttggggatca tcggactagg
    18001 actcattatc tattcggagt gtgaaagcaa caatccgtat ccaagcagat taaagattgt
    18061 gttgatgctg atcggcttga cctccatctt cctgatgacg atcaattggc tgtatcgctt
    18121 ccttcgtgaa cgtgagctag agaagaacaa gacggaacaa tacctgcagc tggaggctta
    18181 tattatggag attgaaaaaa tgtacgaaga catccgcggc ttcagacatg actataccaa
    18241 tatcctgtta atgctggacg aggggatcag aactggggat ttggcgatga tcaagcggat
    18301 atatgagagt tctatccaac ctactgcttc acagttgaac ggatattcct atagtctgga
    18361 taacctgatt aatctggacg tgagtgagct caagagtatt attacatcca aggtgctggt
    18421 ggcaaagaag cgtggagttg acgtaaaact ggaaattgat agcggtatca gtgaaatgta
    18481 tatggatatt atagacctat gcagagtaat ctcttgtttc ctggacaatg caatcgatgc
    18541 ggcactagag acctgcaatc cgtccataaa tattgtactg atccatgaag acgatattca
    18601 gacggtgacg atacgaaact cttataatca ttctgcactt gacgggatta aggtgaatga
    18661 tctctacaaa cggaactttt caacgaaagc ggacaatcgg ggtcttggct tgtacaatat
    18721 agcaaaggtg ctgcgcagca acaagtatgt cactttggat accaaaaagg aaccggattt
    18781 tttcacgcaa acattaatta taaagagagc gacatcatga atatttttat cctggaagat
    18841 cagtttatcc agcagcgcat aatggaaaag atggtccgta aaagctgcga ggaacttggc
    18901 atctgctgca gcaacctcat tgtcaccagt aagccggatc tcctgctttt tgaatctaaa
    18961 gcttgtgcga ataacttgta tttccttgat attgaaatct ctggttgtca gatgaaggga
    19021 ctggaagttg cccaggaaat cagaaaatat gatatgtatg ggcatattgt ctttgtcact
    19081 acccacggtc atctgtctcc gattaccttc caatataagg tagcagctct tgatttcatt
    19141 atcaaggatg ctactcagga tgaaatggaa aaaaaggtaa gagaagttct tgttgttgcc
    19201 catcaaagaa agcctgtgtt ggatgtcaat gattggttta tactcgacaa taaatttacg
    19261 aaatttcaaa tttccttctc cagcatttat tattttgaaa caacgggtgt tccccacaaa
    19321 atccgtctgg tttccgaaaa cagaactctt gagttttacg gcgatctgaa agatattgag
    19381 gctaaggacc caaggttgtt ccggtgtcat cgggcattta tcgtaaacct gatgaaggtg
    19441 gaatctatag ataagagcaa gaaggagatc atttttcaaa ccaatcagaa ttccggagaa
    19501 gcaaggcgca ttattcccgt ttcccgccaa ttgttgaagc acctcttaga taagatggga
    19561 gaccggagcc tcctgaacag acctgtttac gaatagaata gacacggagg gcatagtcct
    19621 tcgggaagaa atggggagga atatggaaca aagattatcc gttcaagcag aggtgaaagg
    19681 cattgatgcc accagtttaa aattaattgc agtattggca atgctaattg atcatattgg
    19741 agggctattt tttgccgatt ttttgggctt tcaggtggta ggcagaatta cattgcctat
    19801 catggctttt tttgtagccg aaggatatat ccataccaga agcttcaaaa aatatacaat
    19861 gcgccttgct ctaaccgggc tagccagtgt ggtgccttac ggattggtat ttaaagattg
    19921 gtatacttcg ggaaacatca tgctaacgtt gttgatgggc ctactggcaa tatggttcta
    19981 tgacaacacg accaatcctg tacttaaata cttggcgatt tcagctcttt gcgtagtctc
    20041 ttttttggga gactggagtg taattggagt gttcctggtt ctggctttct atgtggctcg
    20101 caaacaacag aagatttata acggatggat tattgcaata attgcgctta tgttcatttt
    20161 cggagtcatc attatatggg ctgttcccga ttcgctcagc atcatgggca tcaacgccag
    20221 cacaatgaac gaatatcttt atccgtttgc gatcggcggg gcctgtattt ttgccctccc
    20281 tctgctatcc cgatataacg gagagagggg aaaaggctca cgagccttct tctatttgtt
    20341 ttatcctctg catttgctcg cgctctatct gctgaagttg gctattgagt attacatata
    20401 agaaaggatg tctaataagt aactaaaata aaaaaatgga cgggagacga catgttttcc
    20461 gtctaatttt tgcggtttga cgaactattc gaatgttgat gaagcacgaa atatttgagg
    20521 attgaaggag gagcagcatg aagattatgc ctatacagaa acgagggatc tccaatagtc
    20581 ggctggtgct cggttgcatg ccttttggtg gagaatggag ccatgcaccg tttacacagg
    20641 agcatgttgt tgaagcggag agagctgtag atgctgcaca atccatcgga attacgatgt
    20701 ttgatcatgc ggatatctat cgtatgggaa aagcggaaga aattttcggt cggattttaa
    20761 agggacagcc aggcttgcgt gaacaaatcg tcattcaatc caaatgcgga atttttctgc
    20821 cggatggtac gctcccgggt cgttttgatt tctcatatga tcatattatg gagtccgtgg
    20881 acggtatcct gaagcgtctg agtactgaat atttggatat cctgctgctg caccgccccg
    20941 atccgctggt agagccggaa gaagtagcaa aggcgttcag cgagcttaag acatccggca
    21001 aagtacggca ttttggcgtt tccaatatga atgtaagcca aattcgtttt ctggagcgca
    21061 gcctaacgga gccgctgatt gctaatcagc tggagatgag cctggcacat ctgcatttta
    21121 tagatcagac cgtacacgtg aaccagcagg cagggacgaa tgtacatttt ggcgaaggtt
    21181 tgctggaata ttgccaaacc gaggatattc agctccaggc ttggggaccg ctggcgcagg
    21241 ggcgttttag cggaggttct ctggaaggaa aacctgagca tatccgtaag acggcagaac
    21301 tggtgcagaa gctggcctct gaaaagggga cgacacgcga agcgatcgtc ctgggctggc
    21361 ttatgaagca tccggcacgg attcagcctg tcattggcag cgccaatcct gaacgaatcc
    21421 aagcatgtca ggatgcagaa cgccagagcg aactgatgac ccgtgaagag tggtatcaat
    21481 tgtatgtaag tgcgcgcggg caagccttgc cgtaactggt actgcggact agcttgttac
    21541 agcagacgtg tgcggatgta agtacatgac ctcgtttcgt ttatacgtac tgtatttaat
    21601 aggccctcct ttcgtctcat taacagacgg aggggggcct ttacgtggtt acatcctata
    21661 tgtcttcagc agctattcct cttcgtaccg tgcgagggct ttggctgttg tttctttcat
    21721 tcgtgagatt agccgtgagc cttggacgac cttgacacgc ttgccgagga agcggatttt
    21781 ggataacaca tattcacact cgtctgcctg gaaagtgagt gtaatgcgat aggtatctgc
    21841 ttcctgatca tattcgacct ccttttcaaa acaggaaaaa gcatataaaa tacgagacat
    21901 ttcaccgttg tatacaggaa taatttcgat gatgccctgt tctttgcgcg actccagtat
    21961 accgagtatt cgttgggtaa acttctcggc ttcttcagga agaatctcat cttccgtgac
    22021 ggttacgatg ttggacagct tagtggacat gaatgcgcgg tgccgtcgat tataccacag
    22081 caggctccat tcttttttga ccatagaaaa ctccagctta taaggaaatc cggacattcg
    22141 ctcatgtagg cgtccgttgc gcagtttgta ggtcatacag atgcctgaac gggatcgcag
    22201 aatggaacgc aattcacgca ggagtggatg ataaaccgaa gcagcaggaa cccctgcttt
    22261 ttcccgcagg ctgccatcgg cctccagagg ctcgtcgtct gcaagtaatt gccaaagctt
    22321 atcaagtgta ggcggggtaa aagccgctgt cgctgccgag tctgtaagca tggacttgag
    22381 ccagactctt tcctgcgatg tggtagcaaa agcgcccgat tcatccagcc gtgagacgat
    22441 ctgatagtta aatattttct cgaacaggct cataataggc ttgcagctcc ttccattcct
    22501 gtctgaattc cttacgcagc cgctggggct ccaatacctc acagcttgat ccgaagctgc
    22561 gaatccacgg tttaatctca gtgattccat tcactgtgat ttcgtagata aaggattcac
    22621 tttcttcctc cgtaatcgta ccccattgtc cttgtgacag cacacgttcc cgaataaagt
    22681 tgcgttttgc cccttcggga ttaaaaaaac gtacccttac cttcacggga cgacccgtat
    22741 caacaagcca gctgtaccgc attttttcct ccaacacggc taacaggtcg gcataaagct
    22801 gttctgggac aggcttgccc tccaccaatt gggtcatgcc ctccatacga aacttcatga
    22861 ttcctttgcc gcccacatga ccaagcacgt accaacgtcc atattgatga tcatagatga
    22921 cttgcaaggg cagaatggta tgttcacggc cttcagtctc tttttcaaat cgtgggttgg
    22981 tgttctgtga cccgtacatg cttcgtttgg atgccgaaaa atataaaaag tttacgcagc
    23041 ggcgttgccg aatggcatgc agaagcggat gaatatgggc ttcgtccaga atgcgtgaat
    23101 aataatggta tttatataaa aaaggctctg ccatctcccg atctccgagc tgacggcgca
    23161 tggccttttt aagatgatct cgcaacagat atccctgcac agaggggagc tgagtgttgg
    23221 ccataatgtc cacaaaatca tataagtcca gtaattcctc gtccgtcagt tctgtcacca
    23281 gatcgttacg gacagcatag cgatagggtc tgccgccagg ctccttacga actacgccga
    23341 cttcgaccag atatttcaga tcagaacgga ttgttttttc atccggcagt gcactgtcgg
    23401 aaggcagccc attgcagcaa gcgtccagca gttccatggt ggtcataggc tgtgattgca
    23461 gcgctgtcag cagaagggat aagcggacgc tttccgattc cttgagcgat ttggcccgaa
    23521 acaggaataa caataacgga tcagcggatt cgtaataatt aaagcgcagc atctcattaa
    23581 aatcatgtcc ctgttccgca ggcaactgct gttgtacgga ttggacaatt tccttgagac
    23641 gccgaatcgt tttatcaaag gtgtgcaccg aaatgccaag tctgtctgca aattgctgcc
    23701 gattataagc gccgctggtt agtgtgagca tgcgcaggaa ttgaatttct ttatcaaaac
    23761 tctctctcgc catgatgcat tccccgtttc tgtagccgtt ctccgaaaac aagtatccct
    23821 ttattctaac agggaaggga tgcaggaaaa aggtaattta ttcatctttg taatactttc
    23881 accatgttca tgacttccaa aataaaggat tatagggata taaggtagca cgataagtaa
    23941 gaagcaatac ataacagaag ggtgatgcaa catgtttgga cgatttaaaa atgaagtgtt
    24001 atatccatgg gtaggtaagc tttcgattta tgaaacgatt aagcagggac tggaccctca
    24061 gggaaggctt acggatgatc atttgccgga tgatgaagaa tactgggcag gtcacacgat
    24121 gcgttgggtg gcaggggggc tggatggagc gtttgggcat cacggcgctg gtggagatgg
    24181 agagactgag aaaattaagg agctagcaca cttgttgtcc agacaatgcc gcaagccagg
    24241 gatgaaaaca agacgtgaga cgtatgtacg cttgatggaa gaaaatgcgc tcagcctgat
    24301 tgatccgctg ctagatgcgg tgcgcgaaca tccagcaatt cagccggatc gattgtatga
    24361 ggaagcgcgt tggctggccg aacacggagc acatcgcaat gtggtgaagg tcggtattgc
    24421 gctgctcgga ttgctggaga cagagcagca ccacgagctt attttaacgc tagccaagca
    24481 tgatgaattc acgctatatg cggctgtagc tatccgtaat atttcggatc aggccaatga
    24541 gcagttgtat aatttagcct tacaggtaca tggttgggga cgtattcacg tcgtggaacg
    24601 actggagccg gcgcggcagg aaatacgtga ttggttatta cgggaaggat tccgtaacaa
    24661 tgtcatgtat gagtaccttg cttatgaatg cgctcataaa ggcgagctgc atacagccat
    24721 ggctgtaccg cacattgatc gggagttgtt tgacggagca ggcgatatac tgtcggcttt
    24781 gctggcagca ggcggacctg cggaaagtat agacgattat gagcatgccg ctatggtcat
    24841 aggcaactac cttcgtcatg ctaagactat gtgtacgact gtgaagcatc ttacgatcat
    24901 catggatatt gcggacttcc tcgatgaaga agacgattca tgggaggcac gttatgagca
    24961 tgaatggacg ccggaattac gtaaacgtta cgcgtcggta tgccagcaga tgatggacga
    25021 tccgcagtgg gtgaagctgg tagagcagga actacatcat gcagattcac cgcatcttca
    25081 ctgtgccatt cgcgcagctc gaatgctagt actagatgta tggcccgtgc tatttgatca
    25141 attaagcaaa cacccagtca agcctaatct gtactttgaa cttagcaaga cagaggatga
    25201 acagcgggca tgtaagctgg tggcttttgc agaaaagcac ttgcctctgg gagagatagc
    25261 ttccggtcct gctgatgtgc cgggctttgg accagagtat gaagcgcatc aatgtctggg
    25321 gatgctgctg caactattgt cttcttacga aggaatggga caagagctag ttgctaccgg
    25381 actttggagc ccggtgacct ccaatcgccg tgcagcgctt catgtactca aggaatggcc
    25441 ttctgagatg tggggagagg caacgataga gcgccttcgt tgcttatcgg aagctgaaac
    25501 ggaggagtcg atcagagaac agatttggga aatactttaa ggataaggga gggaacaaca
    25561 tgacagatat gaagcatggg cagggtttca ttcaaccgga aatgcgcgaa acgattttgc
    25621 gtgagctgcg cgcgttggag caggaagagc aggtgcgcat tgtgtacgcc tgtgaatcag
    25681 gcagtcgggc atgggggttt ccttcacagg acagtgacta tgatgtacga tttatttatg
    25741 taagacccat agaatggtat ttatctattt ttgataagcg ggatgtgatt gagcggccaa
    25801 tcagcaatat gctggatata aacggttggg atttgaaaaa ggcgctccat ttatttcgca
    25861 aatccaatcc gcctttgctg gaatggctgc aatctccgat tccctatctg gagcaatatt
    25921 cagtggccga tcagatccgt gcaatctcgc cgttaacctt ctctccgaag tcctgtatgt
    25981 atcactatct gaatatggca cggggaaact atcgggacta tttgcaaggt gaacaggtga
    26041 aaattaaaaa atatttttac gtgctgcgtc cgctgctggc ctgtggctgg attgaacgtt
    26101 acaacagtat gcctcctatc aaattcgtag acttgctagc ggaattcatt ccggtagata
    26161 ccgaacttta tcaggtgatc gagcatttgc tggagcgtaa aaaagcgggc gaggagctgg
    26221 atatggagcc gcagctttcg gtggtgaatg attttattga gcagcaaatt gcttattttg
    26281 aacagaaggc gcccttgctt cagcatatgg agggcggacg ggatcagcaa ttggacgaga
    26341 tgttccgcgc tgcggtgaat gaagtatgga aaacataagc tgggaaggag aagtggagta
    26401 tgcacatcac gctaaaagca accggaaaca atgccgggat gatttcgcat ttgctcgcca
    26461 agaaccctta caatacgtat gatcgcacgg aaaagggtgc tcgtgtacgc atggtgtaca
    26521 ccgtttttac ggaggaagag gcagaaatcg tcattcaggc ctcgccagat tcgatagatt
    26581 tggtcaaaaa tagtccggat agctatgaca ttacaacata tattaatgat cgggagtttg
    26641 taaccagcag cttgttttgc acctatattc gcggcgcgct tggcacggcc ttgaacggca
    26701 aacccaagga agactatgca gcatgggtga cgcatccttt tgcgctggag ttatcgtttg
    26761 ggcctgttgc gtcagatttg ccggatgctg tggtggaggg actatttgcg ccgctgggct
    26821 atcaagtgac catcgaacga gggaaagcgg attattcttt tcagctgaaa aatcgaagca
    26881 ccgtcagata tgtcacgcta agtggccatc agacggtgca atatgcgctg cgtcagttat
    26941 tgctgttaat tccagtgttg gataattata agcactacta tattagcgaa gaagagtttg
    27001 ataagctgaa acgttacggt gaaggctggc tgcaagagca tccgatgcgc gagctcatca
    27061 ttcgacgcac gcttcatttt accaatctga ttgagcaatt tgagcaatct gattctgctg
    27121 ctacacagac tgaaaaacat gcggtccaag aacaaaacca taatcacgaa caggatcagc
    27181 agcaagatca gtcactggag gaaggaaagc aacagcctgt aatgcggcta aatgagctgc
    27241 ggtatcaagc cattatggat gtgattcgca agctgccccg aagacagaaa atcgtagatt
    27301 ttggatcagg ggaagggaag ctttcggctc ggatggctcg aatcaagggc att
//
