LOCUS       NZ_JAHTIK010000001     10852 bp    DNA     linear   CON 01-NOV-2023
DEFINITION  Kitasatospora sp. DSM 101779 AL-KSAMP_AS10_SC01, whole genome
            shotgun sequence.
ACCESSION   NZ_JAHTIK010000001
VERSION     NZ_JAHTIK010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kitasatospora sp. DSM 101779
  ORGANISM  Kitasatospora sp. DSM 101779
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8354403)
  AUTHORS   Samborskyy,M., Nasim,S., Bilyk,O. and Luzhetskyy,A.
  TITLE     Kitasatospora nimphea DSM101779 genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8354403)
  AUTHORS   Samborskyy,M., Nasim,S., Bilyk,O. and Luzhetskyy,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2021) DNA Sequencing Facility, Explogen LLC, 20
            Zelena Street, Lviv 79004, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 24-JAN-2021
            Assembly Method                   :: Newbler v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/01/2023 05:30:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,790
            CDSs (total)                      :: 7,686
            Genes (coding)                    :: 7,384
            CDSs (with protein)               :: 7,384
            Genes (RNA)                       :: 104
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 302
            CDSs (without protein)            :: 302
            Pseudo Genes (ambiguous residues) :: 0 of 302
            Pseudo Genes (frameshifted)       :: 70 of 302
            Pseudo Genes (incomplete)         :: 265 of 302
            Pseudo Genes (internal stop)      :: 17 of 302
            Pseudo Genes (multiple problems)  :: 46 of 302
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:18:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2679964
            Orig. end                         :: 2690816
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHTIK010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10852
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10852
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10852
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5852](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5852
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1048..1452
                     /gene="msrB"
                     /locus_tag="KSNIM_RS12425"
                     /old_locus_tag="KSNIM_12280"
     CDS             1048..1452
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138594.1"
                     /locus_tag="KSNIM_RS12425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12280"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_263103300.1"
                     /transl_table=11
                     /translation="MTHEIQKTEAEWRAQLSPEEYHVLREAGTERAFTGEYTDTKTVGV
                     YGCRACGAELFSSETKFESHCGWPSYFAPLAEDRVEYIQDTTFGMRRVEVRCARCGSHL
                     GHVFEGEGYDTPTDQRYCINSISLTLKPAE"
     misc_feature    complement(1527..1544)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            1581..3695
                     /locus_tag="KSNIM_RS12430"
                     /old_locus_tag="KSNIM_12285"
     CDS             1581..3695
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF014404.3"
                     /locus_tag="KSNIM_RS12430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12285"
                     /product="restriction endonuclease"
                     /protein_id="WP_263103301.1"
                     /transl_table=11
                     /translation="MLAEAQRQQHRREEAQRRADAAAQRQYERARREAERAAAQGQREA
                     LRAYRQSREADAARRTAELEERVAALRGTLAAGLRGRPFSPADLAAPAAAFDPGQLGVP
                     VPMPDQSWYLIPPLTGAQAFDPAARRTWDEQAAQARARFEQDWYAAQAAEQERQRRLAE
                     YRAEFDAWLASRQQLAARAGQLVAGLRSEAPEAVEEYFETALGWRDDWPEGFPHTAEAV
                     WDAGARQLVVEWPLPDSSVVPAVARHRYVKADDRDAEVARPAGERRTLYREVVAQCALR
                     VLAEAFRADDGELLSSVVVHGVVEAVDPATGREESRCLVSVAAERAGFLALDLERVAAV
                     DCLVEALDGRLSARPDKPEAVRPHATGSPSAAAAAPEGDEGPDLFTMDPIAFEELIAEL
                     FRRRGLHTRTTARSGDEGVDVLAEDPDPITGGRIVIQAKRYRHTVPPTAVRDLDATMAR
                     CGANRGILVTTSGFGPGSRRWVEGRPLTLVDGPMLVALLREHGLAGRLGPDGAAGRGTR
                     RQAAPPAPTVLAPGQNAVLPESALGALTVRFSSAGADADLTLLLLTAEGRVRSDGDFVF
                     YHQRSAAGGAVQLGEKAAADGRRTESAVLRPADLPADVHRVAVSVNMDADTALTCAGLI
                     DADLLLHAADGTAWSFRPPSDPAVSAMLVAEVYRHRPAGGAEVWKVRAVGQGWADGLAG
                     LARAHGVDVG"
     gene            complement(3882..4793)
                     /locus_tag="KSNIM_RS12435"
                     /old_locus_tag="KSNIM_12290"
     CDS             complement(3882..4793)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059237.1"
                     /locus_tag="KSNIM_RS12435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12290"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_263103302.1"
                     /transl_table=11
                     /translation="MTLTIRAFRPDDAPAACAALRAGRPYLVTTPETVAWQVAAQPHLR
                     MLLAEADGRIVATARFGAYPDSEEPGHGFAAVHVVPAHRRQGAGTALLAATEEALVAEG
                     VRHAHCWVDDDPAAHAFAAGRGYTCGRVAYFAGRDLTAPLPPLPARPPGVELRTAADFA
                     DDPHPLYLVDVEGTRDEPGDVDLADQGYASWLAEIWHRPDLDRKLTTVVLADGRPVGFS
                     AAQTDGEGRYWSSFTTTVRAHRGRGLAKLAKADSLHRARAAGITAAYTHNDGSNAPMLA
                     VNDWLGYERCAAEWKYSRELTA"
     gene            5001..5852
                     /locus_tag="KSNIM_RS39075"
                     /old_locus_tag="KSNIM_12295"
     CDS             5001..5852
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138590.1"
                     /locus_tag="KSNIM_RS39075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12295"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_317634011.1"
                     /sec_met_domain="DUF692 (E-value: 8.6e-88, bitscore: 292.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHSTEPPRLGVGIGWRAEIDTAVERLSGVDWVEVVAENVCADHL
                     PRSLEVLRGRGVTVVPHGVSLGLGGAEPPARHRLERLAGVAEALGAPLVTEHLAFVRAG
                     GMESGHLLPVPRSRDSLRVVAENVRIAQDQLPVPLALENIAAHLRWPDDELTEGEFLAE
                     LVERTGVRLLVDVANLHTNRVNLGLDVTAELARLPLEALAYVHVAGGVERDGVWHDTHA
                     HPVTEPVLEVLAELCGRAVPPGVLLERDDAFPPPAELAGELDAIRAVLERAPLAEGVRH
                     GG"
     gene            5845..6366
                     /locus_tag="KSNIM_RS39080"
                     /old_locus_tag="KSNIM_12300"
     CDS             5845..6366
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSNIM_RS39080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSNIM_12300"
                     /product="hypothetical protein"
                     /protein_id="WP_317634012.1"
                     /transl_table=11
                     /translation="MAEPDEYLLRGDDAELAVARARLARRQTELMAALVAGGPVPEGFD
                     PAQVATQARGLLAKRRDTTARVVPEPARILGADWRPLFDRYARQGPQRGGYRADAREFA
                     AWALAAEPAAAWHAELEHWLRPAAAAHAPGPLRAARAVLSGTVLARTVHDRLRRRGGAD
                     THGRPAPSRG"
     gene            6419..7441
                     /locus_tag="KSNIM_RS12445"
                     /old_locus_tag="KSNIM_12305"
     CDS             6419..7441
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="KSNIM_RS12445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12305"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_263103303.1"
                     /transl_table=11
                     /translation="MWSTEFTVALVLVLATGAAVGVTHARLRRVPHPRGLSGRGLELME
                     TAFLAGGPARVAVTALVRMQQEGRVIVARSGLVTVTDPAPRDAVEAALIDAAGPGRQQD
                     ADVLRRQVARSAAVQEIGDRLADRGLMRRPDRHRAVVRARRLMGLALLATVVLGVFAMV
                     DWTSRTFDGRYTGAPPVFPFAVLLVAGVFYMAATRPDKGRVTPAGRRQLSMMKEGGAWR
                     PYDVVAPVAALTVLGALALEGTDELDDEMRAALTARQLAASSSASSSSSCSTATWCGSG
                     SDSGSSSSCGSSSCGSSSSSCGSSSGCGSSGSSCGSSGSSCSSGSSCGSSCGGGGCGGS
                     "
     gene            7518..8288
                     /locus_tag="KSNIM_RS12450"
                     /old_locus_tag="KSNIM_12310"
     CDS             7518..8288
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049030.1"
                     /locus_tag="KSNIM_RS12450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12310"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_263103304.1"
                     /transl_table=11
                     /translation="MWVLLLIPACAAAAFSCLQLVRVATRADLLDGLGSRPPEAVGIGL
                     YETAYLAGGPGRVVELALVLMAGRGRLHLAHTGWTTVVDPRGRSRLERALIEQIGPEGQ
                     CRTAPLRASLAAHPTVREIGDRLARAGLATPETVRRDTSRAVRHVRMALLLCVLLLAAS
                     LALAAPGTGDAGAAIAWFSLPLILTCGTLLMARVDVHTYTRFAAPAGLEVLRTARVPRQ
                     LGHDRDPEQALLTAVAMVGPAALTDERLRAALRT"
     gene            complement(8356..9069)
                     /gene="hemQ"
                     /locus_tag="KSNIM_RS12455"
                     /old_locus_tag="KSNIM_12315"
     CDS             complement(8356..9069)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138586.1"
                     /locus_tag="KSNIM_RS12455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12315"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_263103305.1"
                     /transl_table=11
                     /translation="MTESTEQQPVKKKARDLNQVIRYTMWSVFKLKGELPEDRATLAAE
                     VDELFAQLDAKDVTVRGTYDVSGLRADADVMIWWHAENSDDLQEAYNRFRRTAVGRVLE
                     PVWSNMALHRPAEFNKSHIPAFLADERARDYVCVYPFVRSYEWYLLPDEERRAMLAEHG
                     MMARGYPDVRANTVASFALGDYEWLLAFEADELHRIVDLMRDLRPSRARLHVREEVPFF
                     TGRRKPVAELLAGLV"
     gene            complement(9066..10472)
                     /gene="hemG"
                     /locus_tag="KSNIM_RS12460"
                     /old_locus_tag="KSNIM_12320"
     CDS             complement(9066..10472)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138585.1"
                     /locus_tag="KSNIM_RS12460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_12320"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_263103306.1"
                     /sec_met_domain="DAO (E-value: 6.5e-09, bitscore: 34.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEPHVVVIGGGIAGLAAAVFLSDGPHRVTVLEASERLGGKLMAG
                     EVGGVRVDLGAESMLARRPEAVELARAVGLADELEPPTGAKAAIWTRGALRPLPGGQLM
                     GVPGDLDALAASEVLSADGLDRARHERPTRVGEDVAIGAYVSARLGREVVDRLVEPLLG
                     GVYAGHADEISLRAAVPQLLPLARGGGALVDGVHELVGRARPDAGPVFQGIRGGLGTLP
                     EAAAAHLRRGGADLRTASPVDELRRTPEGWRVVVGGEALHADAVVLAVPAPQAAALLRT
                     DAPAAAAELDTVEYAGMALVTMAFERADAAALPYGSGFLVPPVDGRAIKASTFSSYKWG
                     WLDRAAPEAFLLRTSLGRHREEAALDLPDEELVARSLADLERATGLRAAPYATAVTRWR
                     AGLPQYPVGHLDRMTRVRRLVAEAGRLAVCGAAYDGVGIPACIGSARRAVNELLTPADG
                     AGAPEGTMRT"
ORIGIN
        1 gcatgctggc ggtcagcctc ggcgagctcg gcctcgaccc ctcgtacgcg atcggcggcg
       61 acctggacgc gccgggctcc aacgcgcacc acggcaccgg cgacatcttc gtcgcggagg
      121 ccgacgagag cgaccgcagc ttccacaagt acgcgcccga ggtggcgatc gtcctcaacg
      181 tcgagctgga ccaccacgcc aactacgcct cgatcgagga gatccaccag tccttcgaga
      241 ccttcgtcgg ccggatcgtg cccggcggca ccctggtggt ctccgccgac cacgagggcg
      301 cccgggagct gacccgccgg gtccgcggcc gggtgggcct gaacgtggtg acggtcggcg
      361 ccgccgagga cgccgacgtg cgggtgctct cggtctcccc gcgcggcatg accagcgagg
      421 tcaccgtgcg gctggacggc gaggagctct ccttcaccgt ctccgtgccg ggccggcact
      481 acgcgcacaa cgcggtctcc gcgctggccg ccggcgtggc gctcggcgtg cccgccgcgg
      541 acctggcgaa ggcgctcggc gcctacaccg gcgtgcgccg ccggctgcag ctcaagggcg
      601 aggccgcggg cgtgcaggtg atcgactcct acgcgcacca cccgaccgag atggccgccg
      661 acctggaggc gatccgcgag gccgcaggcg ccggccgggt gctggtggtc ttccagccgc
      721 acctgttcag ccggacccag cagctcgccg acgagatggg cgacgcgctg gccctggccg
      781 acgcctcggt ggtgctcgac atctacccgg cccgcgagga cccgatcccc ggcgtcacca
      841 gcgccctgat cgtggacgcc gcccgccggg ccggcgccga cgtcgccgcg gagcacgagt
      901 tcgccgccgc cccggagcgg ctggccgccc tggcgaagcc gggcgacctg gtgctcacca
      961 tgggcgcggg cgacgtgacc aacctgggtc cggaaattct cgcccgcctc gccgacgttg
     1021 cacccggtgc ctgatgggag gacatccgtg acccacgaga tccagaagac cgaggccgag
     1081 tggcgggccc agctgtcgcc cgaggagtac cacgtgctcc gcgaggccgg caccgagcgc
     1141 gccttcaccg gcgagtacac cgacaccaag acggtcggcg tctacggctg ccgggcctgc
     1201 ggggccgagc tcttcagcag tgagacgaag ttcgagagcc actgcggctg gccctcgtac
     1261 ttcgcgccgc tggccgagga ccgcgtcgag tacatccagg acacgacctt cgggatgcgc
     1321 cgggtggagg tccgctgcgc ccgctgcggc agccatctcg gccacgtctt cgagggcgag
     1381 ggctacgaca ccccgaccga ccagcgctac tgcatcaaca gcatctcgct gacgctcaag
     1441 cccgccgagt aggaccgggc cccgcgagca cgcacccgca cgccctgtca ccgcagcgcc
     1501 acaccgtgcc agactgatca tcggtcgaac cgcacgagag gacaacggtg gcagggcgtc
     1561 gcacttccgg agtactggcc atgctggcgg aggcacagcg ccaacagcac cgccgggagg
     1621 aggcgcagcg ccgcgccgac gcggccgcgc agcgccagta cgagcgggcc cggcgggagg
     1681 ccgagcgggc ggcggcccag ggccagcggg aggcgctcag ggcctaccgg cagagccggg
     1741 aggcggacgc ggcccggcgc acggccgagc tggaggagcg ggtcgcggcg ctgcgcggga
     1801 cgctcgccgc gggcctgcgc gggcggccct tctcgcccgc cgatctggcg gcgcccgcgg
     1861 ccgccttcga ccccgggcag ctgggggtgc cggtgccgat gcccgaccag tcctggtacc
     1921 tgataccgcc gctgacgggc gcgcaggcct tcgacccggc ggcccgccgg acgtgggacg
     1981 agcaggcggc gcaggcccgc gcccggttcg agcaggactg gtacgccgcg caggccgccg
     2041 agcaggagcg gcagcgccgg ctcgccgagt accgggccga gttcgacgcc tggctggcct
     2101 cccggcagca gttggcggcc cgggccgggc agctggtcgc cgggctgcgg tcggaggcgc
     2161 cggaggcggt cgaggagtac ttcgagacgg cgctgggctg gcgggacgac tggccggagg
     2221 gcttcccgca cacggccgag gccgtctggg acgccggggc ccggcagctg gtggtggagt
     2281 ggccgctgcc ggactcatcg gtggtgccgg cggtcgcccg gcaccggtac gtgaaggccg
     2341 acgaccggga cgccgaggtg gcccggccgg ccggcgagcg gcggacgctg taccgggagg
     2401 tcgtggcgca gtgcgcgctg cgggtgctgg cggaggcgtt ccgtgcggac gacggggagt
     2461 tgctctcgtc ggtcgtggtg cacggcgtgg tggaggccgt cgatccggcg accggccgtg
     2521 aggagagccg ctgcctggtt tcggtggccg ccgaacgggc cgggttcctg gcgctcgacc
     2581 tggagcgggt cgcggcggtg gactgcctgg tggaggcgtt ggacggccgg ctgtcggcgc
     2641 ggcccgacaa gccggaggcc gtccggccgc acgccaccgg gtccccgtcc gcggccgcgg
     2701 ccgcaccgga gggcgacgag gggccggacc tgttcaccat ggatccgatc gccttcgagg
     2761 agctgatcgc cgaactgttc cgccggcgcg gcctgcacac ccggacgacc gcgcgcagcg
     2821 gcgacgaggg cgtcgacgtg ctcgccgagg acccggaccc gatcaccggc ggccggatcg
     2881 tcatccaggc caagcgctac cggcacaccg tgccgcccac cgccgtccgc gacctggacg
     2941 ccaccatggc ccgctgcggc gccaaccgcg gcatcctcgt caccacctcc ggcttcggcc
     3001 ccggctcgcg gcgctgggtg gagggccggc cgctgaccct ggtggacggg ccgatgctgg
     3061 tcgccctgct gcgcgagcac ggcctggccg ggcgactcgg accggacggt gcggcgggtc
     3121 gcggcacccg acggcaggcg gcgcctccgg caccgacggt gctcgcgccc gggcagaacg
     3181 cagtgctgcc ggagagcgcg ctcggtgcgc tgaccgtccg cttctcctcc gcgggtgcgg
     3241 acgccgatct gacgctgctg ctgctcaccg ccgagggccg ggtgcgctcc gacggggact
     3301 tcgtcttcta ccaccagcgc agcgcggccg gcggggcggt gcagctcggc gagaaggcgg
     3361 ccgcggacgg gcggcgcacg gagtcggcgg tgctgcggcc ggcggacctc ccggcggacg
     3421 tccaccgggt cgccgtctcc gtcaacatgg acgccgacac cgccctcacc tgcgccgggc
     3481 tcatcgacgc cgacctgctg ctgcacgccg cggacggcac cgcctggtcg ttccggccgc
     3541 cgtccgaccc cgcggtgtcc gcgatgctgg tcgccgaggt ctaccggcac cggccggccg
     3601 ggggcgcgga ggtgtggaag gtccgcgcgg tcggccaggg ctgggcggac ggcctggccg
     3661 gcctggcccg cgcccacggc gtcgacgtcg gctgaaggga ctcccggggg cagcacgtca
     3721 ggggcgctgg gggtacctcc cgcggcgaag gctgggggcg gaactgcgca agtcggatac
     3781 gggccactgc acggatcagg ggtcggcccg attccgtagt gacagccacc ctcgggctgc
     3841 gcagctcccc gcgcccctga cgtcctgccc tcccagcaac gtcacgcagt gagctcgcgg
     3901 ctgtacttcc actcggcggc gcagcgttcg tagccgagcc agtcgttgac cgccagcatc
     3961 ggggcgttgc tgccgtcgtt gtgggtgtag gcggcggtga tgccggcggc gcgggcccgg
     4021 tgcagcgagt cggccttggc gagtttggcg aggcctcggc cgcggtgggc ccgcacggtg
     4081 gtggtgaagg aagaccagta gcggccctcg ccgtcggtct gtgcggcgga gaagccgacc
     4141 ggccgtccgt cggcgagcac cacggtggtg agcttccggt cgaggtcggg ccggtgccag
     4201 atctcggcca gccaggacgc gtagccctgg tcggcgaggt cgacgtcgcc gggctcgtcc
     4261 cgggtgccct cgacgtcgac gaggtagagc gggtgcgggt cgtccgcgaa gtcggcggcg
     4321 gtgcgcagtt cgacgcccgg cgggcgggcc ggcaggggtg gcagcggggc ggtgaggtcg
     4381 cgtccggcga agtaggcgac ccggccgcag gtgtagccgc ggccggcggc gaaggcgtgc
     4441 gcggccggat cgtcgtccac ccagcagtgc gcgtggcgga cgccctcggc gacgagcgcc
     4501 tcctcggtgg cggccagcag ggcggttccg gcgccctgcc tgcggtgtgc ggggacgacg
     4561 tggacggcgg cgaagccgtg gcccggctcc tcgctgtcgg ggtaggcgcc gaaccgcgcg
     4621 gtggcgacga tccgcccgtc cgcctcggcg aggagcatcc gcaggtgggg ctgggcggcg
     4681 acctgccagg cgaccgtctc gggggtggtg acaagatacg ggcggccggc gcgcagggcg
     4741 gcgcaggccg cgggcgcgtc gtcgggccgg aaggcgcgga tcgtgagcgt catagacacg
     4801 tcacgttaac gactcggccg cctcggcgcc ctcgaatatc ggtctccggg acgggagttg
     4861 ccctcgaatc gggcgccgcc ccggagaaag ctcaagttca gctctgagtt cggccgccgg
     4921 tggttggcag ccgtgtccgg ccggtacacc ctcagcagcg gacaccggcg gcgtcggacg
     4981 caggagaggg gggagcgcgc atggcgcact cgacggagcc gccccggctg ggggtgggga
     5041 tcggctggcg ggcggagatc gacaccgcgg tcgagcggct gtccggcgtg gactgggtgg
     5101 aggtggtcgc ggagaacgtc tgcgccgacc atctgccgcg ttcgctggag gtgctgcgcg
     5161 ggcgcggcgt cacggtcgtc ccgcacgggg tgtcgctcgg cctcggcggt gccgagccgc
     5221 cggcccggca ccggctggag cggctggccg gggtggccga ggcgctcggt gcgccgctgg
     5281 tcaccgagca cctggccttc gtccgtgcgg gcgggatgga gtcggggcac ctgctgccgg
     5341 tgccgcggtc gcgggactcg ctgcgggtgg tcgcggagaa cgtccggatc gcccaggacc
     5401 agctgccggt gccgctcgcg ctggagaaca tcgcggccca cctgcgctgg ccggacgacg
     5461 agctgaccga gggcgagttc ctcgccgagc tggtggagcg gacgggcgtg cggctgctgg
     5521 tggacgtcgc gaacctgcac accaaccggg tcaacctggg cctggacgtc accgccgagc
     5581 tggccaggct gccgctggag gctctcgcct acgtgcacgt cgccggcggg gtggagcggg
     5641 acggcgtctg gcacgacacc cacgcccacc cggtcaccga gccggtgctg gaggtgctcg
     5701 ccgaactgtg cgggcgcgcc gtgccgcccg gcgtgctgct ggaacgggac gacgccttcc
     5761 cgccgccggc cgagctggcc ggcgaactcg acgcgatccg ggccgtcctg gagcgcgcgc
     5821 cgctcgccga gggggtgcgg cacggtggct gagcccgacg agtacctgct gcgcggggac
     5881 gacgccgagc tggcggtggc ccgggcccgg ctcgcccggc ggcagaccga gctgatggcc
     5941 gcgctggtcg cgggcggccc ggtgccggag ggcttcgacc cggcgcaggt cgccacccag
     6001 gcccgcgggc tgctcgccaa gcggcgggac accaccgcgc gggtggtgcc cgagccggcc
     6061 cggatcctcg gtgccgactg gcggccgctg ttcgaccggt acgcccggca gggcccgcag
     6121 cgcggcgggt accgggccga cgcgcgggag ttcgccgcct gggcactggc cgcggaaccg
     6181 gccgccgcct ggcacgccga actggagcac tggctgcggc ccgcggcggc ggcgcacgcg
     6241 cccggtccgc tgcgggcggc ccgggcggtg ttgtccggca cggtgctggc ccgcacggtg
     6301 cacgaccgcc tgcgccgccg cggcggtgcg gacacccacg gccggccggc cccgtcccgg
     6361 ggctgagcac ggcaccaccg ggtccgccgg acccgttcga cccacggggg agacaacgat
     6421 gtggagtacg gagttcaccg tggccctcgt cctggtgctg gccaccgggg cggcagtggg
     6481 cgtcacccac gcgcggctgc gccgggtgcc gcacccgcgg ggcctgtccg ggcgcggcct
     6541 ggaactgatg gagacggcct tcctggccgg tggcccggcc cgggtcgcgg tcaccgccct
     6601 ggtgcggatg cagcaggagg gccgggtgat cgtggcgcgg tccggcctgg tcaccgtcac
     6661 cgacccggct ccccgggacg ccgtcgaggc tgcgctgatc gacgcggccg gccccggccg
     6721 gcagcaggac gccgacgtgc tgcgccgcca ggtggcgcgc agcgctgccg tccaggagat
     6781 cggcgaccgg ctggccgacc gcggcctgat gcgccggccg gaccgccacc gggcggtggt
     6841 gcgggcccgc cgcctgatgg gcctggcgct gctggcgacg gtggtcctcg gcgtgttcgc
     6901 gatggtcgac tggacgagcc gcaccttcga cggccggtac accggggcgc cgccggtctt
     6961 cccgttcgcc gtgctgctgg tcgccggcgt gttctacatg gccgcgacca ggccggacaa
     7021 gggacgggtc accccggcgg gccgccgcca gctgtcgatg atgaaggagg gcggcgcctg
     7081 gcggccgtac gacgtggtgg cgcccgtcgc cgcactgacc gtgctcggcg cgctggccct
     7141 ggagggcacc gacgagctgg acgatgagat gcgggcggcg ctgacggccc ggcagctggc
     7201 cgcctcgtcc tcggcgtcgt cgtcctcgtc ctgctccacg gcgacctggt gcgggtccgg
     7261 ctcggacagc ggctcctcgt cgagctgcgg ctcgtccagc tgcgggtcct cctcgtccag
     7321 ctgcggctcg tcgtcgggct gcggttcgtc cggcagttcg tgcggatcct ccggcagctc
     7381 ctgctcgtcg gggagctcct gcgggtccag ctgcggcggc ggcgggtgcg gcgggtcctg
     7441 atccggcttg tcacagtttc gtatcgcggg cggggcacgt gttccccgcc cgcccctgcc
     7501 gggactagaa caagcccatg tgggtgctcc tcctgatccc ggcctgcgcg gctgccgcgt
     7561 tctcctgctt gcagctggtc cgggtcgcca ccagggccga cctgctcgac ggcctcggct
     7621 cccggccccc cgaagcggtg gggatcggcc tgtacgagac cgcctacctg gccggcggac
     7681 ccggccgggt ggtggagctg gcgctggtgc tgatggcggg ccgcggccgg ctgcacctcg
     7741 cgcacaccgg ctggacgacc gtcgtcgacc cgcggggccg cagccggctg gagcgggcgc
     7801 tgatcgagca gatcgggccg gagggccagt gccggacggc gccgctgcgg gcctcgctgg
     7861 cggcgcaccc gaccgtccgg gagatcggtg accgcctcgc ccgggccggt ctggcgactc
     7921 cggagaccgt ccgccgggac acctcgcggg cggtgcggca cgtccggatg gcgctgctgc
     7981 tgtgcgtcct gctgctggcc gcgtcgctcg ccctcgccgc ccccggcacc ggcgacgccg
     8041 gtgcggcgat cgcctggttc tcgctgccgt tgatcctcac ctgcggcacc ctgctgatgg
     8101 cccgggtgga cgtgcacacc tacacccggt tcgccgcgcc cgcgggcctg gaggtgctgc
     8161 gcaccgcccg ggttccccgc cagctcggcc acgaccggga cccggagcag gcgctgctca
     8221 cggccgtggc catggtcggc ccggccgccc tcaccgacga acggctgcgg gcggcgctgc
     8281 ggacctgagt ccgctgcgcc gcccgtgcgg caggaccgtg ccggttcgga ccgcgtccgc
     8341 ccggtccggg tcggctcaga ccaggccggc gaggagctcc gcgaccggct tgcggcgacc
     8401 ggtgaagaac ggcacctcct cgcggacgtg cagtcgggcc cgggacgggc gcaggtcgcg
     8461 catcaggtcg acgatccggt gcagctcgtc cgcctcgaag gcgagcagcc actcgtagtc
     8521 gccgagggcg aaggaggcga ccgtgttggc ccggacgtcc gggtagccgc gggccatcat
     8581 gccgtgctcg gcgagcatgg cgcggcgctc ctcgtcgggc agcaggtacc actcgtagga
     8641 gcggacgaac gggtagacgc agacgtagtc gcgggcgcgc tcgtcggcga ggaacgccgg
     8701 gatgtgcgac ttgttgaact cggccgggcg gtgcagcgcc atgttcgacc agaccggctc
     8761 caggacacgg ccgacggcgg tgcggcggaa gcggttgtac gcctcctgca ggtcgtccga
     8821 gttctcggcg tgccaccaga tcatcacgtc cgcgtcggcc cgcaggccgg acacgtcgta
     8881 ggtgccgcgc acggtgacgt ccttggcgtc gagctgggcg aagagctcgt ccacctcggc
     8941 ggccagggtg gcgcggtcct cgggcagctc acccttgagc ttgaacaccg accacatggt
     9001 gtagcggatg acctggttga ggtcgcgggc cttcttcttc acgggctgct gttcagtgct
     9061 ctcagtcatg tcctcattgt cccttccggg gctccggcgc cgtccgccgg ggtcaacaac
     9121 tcgttgacgg cgcggcgggc actgccgatg caggcgggga tgcccacccc gtcgtaggcg
     9181 gcgccgcaga ccgccagccg accggcctcg gcgaccagcc ggcggacccg ggtcatccgg
     9241 tccaggtggc ccaccgggta ctgcggcagg ccggcccgcc agcgggtgac cgcggtggcg
     9301 tacggcgcgg cgcgcagccc ggtcgcccgc tccaggtcgg ccagcgagcg cgcgacgagc
     9361 tcctcgtccg gcaggtcgag ggcggcctcc tcgcggtgcc ggccgagcga ggtgcgcagc
     9421 aggaacgcct ccggcgcggc gcggtccagc catccccact tgtacgagga gaaggtcgag
     9481 gccttgatcg cccggccgtc caccggcggc accaggaagc cgctgccgta cgggagggcg
     9541 gccgcgtcgg cacgctcgaa ggccatggtg accagggcca tcccggcgta ctcgacggtg
     9601 tccagctcgg ccgcggcggc cggggcgtcg gtgcgcagca gcgcggccgc ctgcggggcg
     9661 ggcaccgcca gcaccacggc gtcggcgtgc agtgcctcgc cgccgacgac cacccgccag
     9721 ccctcggggg tgcggcgcag ttcgtcgacg gggctggcgg tgcgcaggtc ggcgccgccg
     9781 cgccgcaggt gggccgcggc ggcctccggc agggtgccga gcccgccgcg gatgccctgg
     9841 aagaccgggc cggcgtcggg tcgggcccgg ccgacgagct cgtgcacgcc gtcgaccagg
     9901 gctccgccgc cgcgggcgag cgggagcagc tgcgggacgg cggcgcgcag cgagatctcg
     9961 tcggcgtggc cggcgtagac accgccgagc agcggttcga cgagccggtc gacgacctcg
    10021 cggccgagcc gggcggagac gtaggcgccg atcgcgacgt cctcgccgac ccgggtcggg
    10081 cgctcgtgcc gggcgcggtc caggccgtcg gcggagagca cctcggaggc ggccagggcg
    10141 tcgaggtcgc cgggcacgcc catcagctgt ccgccgggca gcgggcgcag ggcgccgcgg
    10201 gtccagatgg cggccttcgc gccggtgggc ggctccagct cgtcggcgag gccgacggcg
    10261 cgggccagct ccaccgcctc ggggcggcgg gcgagcatcg actcggcgcc gaggtcgacc
    10321 cggacgccgc cgacctcccc cgccatgagc ttgccgccga ggcgctcgga cgcctccagc
    10381 acggtgaccc ggtgcgggcc gtcgctcagg aacaccgctg cggcgagtcc ggcgatgccg
    10441 ccgccgatca ccacgacatg aggttctgcc atgtccggca gtcttccact ccttacgcgc
    10501 gcccccgggc tgccccgctc ggccgcggcc ggtccggccc ggccgggctg tcggcggtcc
    10561 gtcaactccg ctgccccgca cgggcggtgt tcaccggggc gaggccggac cgtgaccggt
    10621 tcgggatcac cgggacgggt ccggacaggc cgcgggcgcg tccaatggtg cgaccggcgc
    10681 ggaacaccgc gcggagggac caggggagga cggacatggg gcgcacggac acggggctcg
    10741 cgggcagacg ggtgctggcc ggcaccgcgc tggcggcggt gctgctgctg agcgggtgcg
    10801 gcgcggaggg cggccggtcc tcctcggacg ccgcggcacc cgcccaggcg gt
//
