LOCUS       NZ_JAHTIK010000001     10813 bp    DNA     linear   CON 01-NOV-2023
DEFINITION  Kitasatospora sp. DSM 101779 AL-KSAMP_AS10_SC01, whole genome
            shotgun sequence.
ACCESSION   NZ_JAHTIK010000001
VERSION     NZ_JAHTIK010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kitasatospora sp. DSM 101779
  ORGANISM  Kitasatospora sp. DSM 101779
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8354403)
  AUTHORS   Samborskyy,M., Nasim,S., Bilyk,O. and Luzhetskyy,A.
  TITLE     Kitasatospora nimphea DSM101779 genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8354403)
  AUTHORS   Samborskyy,M., Nasim,S., Bilyk,O. and Luzhetskyy,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2021) DNA Sequencing Facility, Explogen LLC, 20
            Zelena Street, Lviv 79004, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 24-JAN-2021
            Assembly Method                   :: Newbler v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/01/2023 05:30:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,790
            CDSs (total)                      :: 7,686
            Genes (coding)                    :: 7,384
            CDSs (with protein)               :: 7,384
            Genes (RNA)                       :: 104
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 302
            CDSs (without protein)            :: 302
            Pseudo Genes (ambiguous residues) :: 0 of 302
            Pseudo Genes (frameshifted)       :: 70 of 302
            Pseudo Genes (incomplete)         :: 265 of 302
            Pseudo Genes (internal stop)      :: 17 of 302
            Pseudo Genes (multiple problems)  :: 46 of 302
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:18:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 798714
            Orig. end                         :: 809527
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHTIK010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10813
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10813
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10813
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5813](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5813
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    73..88
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    complement(359..373)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     misc_feature    804..819
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     assembly_gap    883..907
                     /estimated_length=25
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <908..1105
                     /locus_tag="KSNIM_RS03775"
                     /old_locus_tag="KSNIM_03740"
                     /pseudo=""
     CDS             <908..1105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566627.1"
                     /locus_tag="KSNIM_RS03775"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03740"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ERAPAPDAGPPPEEVPARLAAAVVELRKADDAAAGDLWPAGIGPA
                     VPAAAEQRGYVLSGRLAHGR"
     gene            complement(1122..3494)
                     /locus_tag="KSNIM_RS03780"
                     /old_locus_tag="KSNIM_03745"
     CDS             complement(1122..3494)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524657.1"
                     /locus_tag="KSNIM_RS03780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03745"
                     /product="FdhF/YdeP family oxidoreductase"
                     /protein_id="WP_263101777.1"
                     /transl_table=11
                     /translation="MNASDRNDDAPLATDTGTTEGAAGANGHRAGNGSGPTPGNRPEFR
                     PYHHPAAGWGAAKSVSRVLVREGALVDGPRAILRMNHENTGFDCPGCAWPDDTKGLHLD
                     ICENGIKHVTWEMTRKRAGKEFFATHTVTELMEWSDFALENEGRLTGPLVYDAATDHYV
                     PISWKDAFALVGRTLRELDSPDRAAYYTSGRLGNEATFLYQLMARELGTNNLPDCSNMC
                     HEASGRAMEASLGTGKGTVDLKDWETTDALFIIGVNAASNAPRMLTALAEAHRRGARIV
                     HINPLVEAAATRTIVPHDFVDMALFHPTATTTLNLQPRIGGDMALLRGIAKAILELSGS
                     DPKALDREFVDRHTSGFEEYRARCEATSWEEIEQQSGVPRAGILAAARIYRDADRSIVS
                     WCLGVTQHEHGVDTVREIVNLLLLRGNVGREGAGPSPVRGHSNVQGNRTCGIDHRPAEE
                     FLDRLAEVCGIDPPRAHGLDTVGTVEAMHRGDVKVFVGMGGNFALAAPDTPYTHEALRR
                     TELTVQVSTKLNRSHLVHGRQALILPCLGRTERDHQRAGVQSTSVEDSMSMVHLSVGMK
                     RPASPHLLSEPAIIAGIARAALPDSATPWEWYVEDYDRIRDTMAKVLDGFEDFNRRVRL
                     PLGFRIKQPARELVFLTPSGRAEFSAAPLPDVVPAPGTLALGTMRSHDQWNTTIYSDDD
                     RYRGIKNLRTLVFMNADDMRERGLGEFDPVDITSTARDGSTRSLHGYLAVPYDIPRGCA
                     AGYMPEMNVLCALGDHSTQSDQPIMKHLKVTVERSAA"
     misc_feature    complement(3693..3708)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.59"
                     /tool="antismash"
     gene            3706..>3921
                     /locus_tag="KSNIM_RS03785"
                     /old_locus_tag="KSNIM_03750"
                     /pseudo=""
     CDS             3706..>3921
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018854162.1"
                     /locus_tag="KSNIM_RS03785"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03750"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGLPPVEGFGSFGSADPFSDLLNRFFGMSAASSPPAVQRVPIGRL
                     LTASSRALIARASQRATGDGSKDLDRE"
     gene            3954..4931
                     /locus_tag="KSNIM_RS03790"
                     /old_locus_tag="KSNIM_03755"
     CDS             3954..4931
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327983.1"
                     /locus_tag="KSNIM_RS03790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03755"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_263107821.1"
                     /transl_table=11
                     /translation="MEAPTPQPVLGPLTTASLFLVLTVDPGGEPVVRELLADLAGLRRS
                     VGFGHPDGRLSVVAGIGSACWDRLVEGPRPAGLHPFRELRGVRHRAPATPGDLLLHIRA
                     ARQDLCFSLGSEIMARLRGAVAVADEVTGFTYLDQRDLLGFVDGTENPVGRAAAEAVLI
                     GAEDPDFAGGSYVIVQKYLHDLDAWNRLPVEQQERIVGRRKLTNVEIDSPGSHVDLNTI
                     TGPDGGERQILRDNMPFGSPGGGEFGTYFIGYARTPEVTEEMLRHMFLGDGPVSHDRIL
                     DFSTAVTGTLFFVPSADLLEDLGAEEDSGAGERGSLGIGDLRNR"
     gene            5001..5813
                     /locus_tag="KSNIM_RS03795"
                     /old_locus_tag="KSNIM_03760"
     CDS             5001..5813
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669186.1"
                     /locus_tag="KSNIM_RS03795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03760"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_263101778.1"
                     /sec_met_domain="Linocin_M18 (E-value: 6.6e-89, bitscore:
                     296.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNLHRELAPVSAAAWADLEQEARRTFTRHVAARRIVDVPEAGGT
                     ELAAVNTGRLDEIRSPDPGVRARLRQAQSLVELRVPFTVDRSQVDDVARGAEDADWGPV
                     KEAARRIAFAEDRAVFEGYPAAGIAGLRACSANEALTLPADPRDYPTVISQAIGELRLA
                     GVGGAYTLALSADAFTAVSETSDHGYPIHEHLRRLLDGEIIWAPAIDGAFLISTRGGDF
                     TLRLGQDLSIGYLAHDTDTVELYFQESLTFLVHTEEAVVPINPAPAAR"
     gene            complement(6265..7569)
                     /locus_tag="KSNIM_RS03800"
                     /old_locus_tag="KSNIM_03765"
     CDS             complement(6265..7569)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514865.1"
                     /locus_tag="KSNIM_RS03800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03765"
                     /product="MFS transporter"
                     /protein_id="WP_263101779.1"
                     /transl_table=11
                     /translation="MTALSPSSGSAAPVQATRATPPSLWHNRDFVRFWLGETVSLLGTQ
                     VTALALPLTAIDAFGATDEQVGLLRFLQLVPYLGLALVIGVWADRARRRPVMLGANLVR
                     LVLLALVPLLYWWHALDLTVLMVIACAVGTASVVFDVSWMSYVPLLVRDRRQYVAASAR
                     MSASSSAADVAGPGLAGVLVSAVGAPAALVVDACSYAVSVVSLLLIRTPEPRPERPAER
                     HLLRELRDGLGFVLRNGVLRALALIGFCCNFSMVTVWTMFLLYGSHDLRLSSTALGGVF
                     ATASAGGLLGAVLSRRVIERFPLGRVYLVAQSALLLGPVLIPCATGPRPVMTAMFVLSF
                     LTTYLGLGIAGVIIVSLRQAVTPQPMMGRMTAAFRTLLFGGGALGGLGAGLLAGHLGAR
                     AALAVAAAGSAVVVLALPASPVVRLRSLPAAPAEH"
     gene            complement(7566..8804)
                     /locus_tag="KSNIM_RS03805"
                     /old_locus_tag="KSNIM_03770"
     CDS             complement(7566..8804)
                     /NRPS_PKS="Domain: Aminotran_5 (32-398). E-value: 1.1e-55.
                     Score: 181.0. Matches aSDomain:
                     nrpspksdomains_KSNIM_RS03805_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179004.1"
                     /locus_tag="KSNIM_RS03805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03770"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_263101780.1"
                     /sec_met_domain="Aminotran_5 (E-value: 8.8e-48, bitscore:
                     161.9, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.5e-05,
                     bitscore: 21.1, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQNSAFAIGPEPLLDIAALRADTPGCASVVHFNNAGCGLTPRP
                     VLRTVVEHLELEAATGGYEAAAARTAEIADFYAATAGLLNTRPGNIAFAASATHAYTKA
                     LSSFDFRPGDTVLTTRNDFVSNQIAFLSLRRRHGVRIVHAPDRPDGSGVDVEAMAALMR
                     AHRPRLVAATHVPTNSGLVQPVAEIGRHCRELGLLYLVDACQSVGQYRIDVEEIGCDLL
                     TATCRKFLRGPRGSGFLYVSDRVLQAGGEPLYIDMHGARWVAPGHYRPVPTAARFEEWE
                     FPYATVLGCAAAVRYALAVGQDAVARRTPALAALLRERLAGVPGVRTLDRGPAPAALVT
                     VAVEGWEPHPFKAALDRRGINSALSFREFAQFDFRDKEVEWCLRLSPHYYNTEDEVAEV
                     AGAVAELAAEGLR"
     aSDomain        complement(7611..8708)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KSNIM_RS03805_Aminotran_5.1"
                     /evalue="1.10E-55"
                     /label="KSNIM_RS03805_Aminotran_5.1"
                     /locus_tag="KSNIM_RS03805"
                     /protein_end="398"
                     /protein_start="32"
                     /score="181.0"
                     /tool="antismash"
                     /translation="HFNNAGCGLTPRPVLRTVVEHLELEAATGGYEAAAARTAEIADFY
                     AATAGLLNTRPGNIAFAASATHAYTKALSSFDFRPGDTVLTTRNDFVSNQIAFLSLRRR
                     HGVRIVHAPDRPDGSGVDVEAMAALMRAHRPRLVAATHVPTNSGLVQPVAEIGRHCREL
                     GLLYLVDACQSVGQYRIDVEEIGCDLLTATCRKFLRGPRGSGFLYVSDRVLQAGGEPLY
                     IDMHGARWVAPGHYRPVPTAARFEEWEFPYATVLGCAAAVRYALAVGQDAVARRTPALA
                     ALLRERLAGVPGVRTLDRGPAPAALVTVAVEGWEPHPFKAALDRRGINSALSFREFAQF
                     DFRDKEVEWCLRLSPHYYNTEDEVAE"
     misc_feature    8781..8792
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     gene            8803..10206
                     /locus_tag="KSNIM_RS03810"
                     /old_locus_tag="KSNIM_03775"
     CDS             8803..10206
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (152-459). E-value:
                     1.1e-26. Score: 85.8. Matches aSDomain:
                     nrpspksdomains_KSNIM_RS03810_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150935.1"
                     /locus_tag="KSNIM_RS03810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSNIM_03775"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_263101781.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-24, bitscore:
                     85.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDGSSTEALLAILRTEIAALAPGDRLPSSRDLIARHGVGPVTVS
                     RAVAQLAAEGVVVTRPGSGTYVTARRTAGSAAPDTSWQSVVLADRRIDAAEEETALPEL
                     PPGTVPLSGGYLHESLQPGRILGAALARAARRPDAWHRAPAAGLATLRALFARQTGGDH
                     GPEDVLVTAGGQSALSMLFRAVAAPGAPLLVESPTYPGALAAARAAGLRPVPVPMDDRG
                     LRPDLLADAFAMTGARLLYCQPTFHNPTGVVLAPERRRQVVDVARAAGAFLIEDDFARH
                     LGHGRAVPRPLAADDRDGTVVHLTSLSKPASPSLRIGAITARGPVVRRLLSLRRADDFF
                     LARPLQEAAVELLSTPAWDRHLRGLGTALRQRCAVLAHAVARELPDWTPAPTPEGGLHL
                     WLRLPPGPTESALADAARAHGVAVDPGHRFFPAEPTAAHVRLAFAAAAEPADLAEAVRR
                     LAAAARSGA"
     aSDomain        9259..10179
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KSNIM_RS03810_Aminotran_1_2.1"
                     /evalue="1.10E-26"
                     /label="KSNIM_RS03810_Aminotran_1_2.1"
                     /locus_tag="KSNIM_RS03810"
                     /protein_end="459"
                     /protein_start="152"
                     /score="85.8"
                     /tool="antismash"
                     /translation="ALFARQTGGDHGPEDVLVTAGGQSALSMLFRAVAAPGAPLLVESP
                     TYPGALAAARAAGLRPVPVPMDDRGLRPDLLADAFAMTGARLLYCQPTFHNPTGVVLAP
                     ERRRQVVDVARAAGAFLIEDDFARHLGHGRAVPRPLAADDRDGTVVHLTSLSKPASPSL
                     RIGAITARGPVVRRLLSLRRADDFFLARPLQEAAVELLSTPAWDRHLRGLGTALRQRCA
                     VLAHAVARELPDWTPAPTPEGGLHLWLRLPPGPTESALADAARAHGVAVDPGHRFFPAE
                     PTAAHVRLAFAAAAEPADLAEAVRRL"
ORIGIN
        1 cgcggcgccg aggccggctt cgacctgctc gaactgcact gcgcgcacgg ctacctgctc
       61 tcgtccttcc tgtcgccgct ggcgaaccgc cgcaccgacg agtacggcgg gccgctggag
      121 aaccggctgc gctacccgct ggaggtcttc gacgccgtcc gcgccgcctg gccggccgag
      181 cggccggtga tcgtgcgcat ctcggccacc gactgggcac ccgacgggaa caccgagcac
      241 gacgccgtgg agatcgcccg cgccttcgtc gcgcacggcg cggccgccgt ggacgtctcc
      301 tccggccagg tcaccaagga cgagcgcccc gcctacggcc gctcctacca gaccccgttc
      361 gccgaccgga tccggcacga ggtggcggcc gccgccggcg ccgccgtcat cgcggtcggc
      421 gccatcgcct cctacgacga cgtgaactcc atcctgctgg ccgggcgcgc cgacctctgc
      481 gcgatcggcc ggacccacct ctacgacccg cactggacgc tgcacgcggc cgccgagcag
      541 gactaccgcg ggcccgccgc ggactggccg ctgcccttcc gggccggcag ccgcaagccg
      601 ccctcggcgc ggacggacgc cgtccggccg cggctgtcac tgctccgggc ggacggcccc
      661 gaccgcgccg tgcacctgcg ctggaccccg cccctggagc cggcccgggt gccctgaggc
      721 gacagcgccc tcgcgcgcgg cggcgccgcc cttgcctccc ccgctccggc ggacgaaccg
      781 gtcgccgacc gggtgctggg cagtgtgctg ggcatcacgg tcggtctgct gtgcgcgctg
      841 ctggtggtgc acgaccgggc cgcggtgcgg gtcgggcggg cgnnnnnnnn nnnnnnnnnn
      901 nnnnnnngag cgcgcgccgg cgccggacgc cggcccgccg ccggaggagg tgccggcccg
      961 gctggcggca gccgtggtgg agctgcggaa ggccgacgac gccgcggccg gcgacttgtg
     1021 gccggccggg atcggtccgg cggtgccggc cgcggcggag cagcgcgggt acgtgctgtc
     1081 gggccggctg gcgcacggcc ggtgaggggg cgcgccgcgg ttcaggccgc cgagcgctcg
     1141 acggtgacct tgaggtgctt catgatcggc tgatcgctct gcgtgctgtg gtcgccgagc
     1201 gcgcagagca cgttcatctc gggcatgtag cccgcggcgc agccgcgcgg gatgtcgtag
     1261 gggacggcga ggtagccgtg cagcgagcgg gtggagccgt cgcgggcggt gctggtgatg
     1321 tcgaccgggt cgaactcgcc gaggccgcgc tcgcgcatgt cgtcggcgtt catgaagacc
     1381 agggtgcgca ggttcttgat gccgcggtag cggtcgtcgt cggagtagat ggtggtgttc
     1441 cactggtcgt gcgagcgcat ggtgccgagc gccagggtgc cgggggcggg gacgacgtcg
     1501 ggcagcggcg cggcggagaa ctcggctcgg ccggacgggg tgaggaagac cagctcgcgg
     1561 gcgggctgct tgatccggaa gccgagcggc agccggacgc ggcggttgaa gtcctcgaag
     1621 ccgtcgagga ccttggccat ggtgtcgcgg atgcggtcgt agtcctcgac gtaccactcc
     1681 cacggggtgg cgctgtcggg gagggcggct cgggcgatgc cggcgatgat cgcgggttcg
     1741 gagagcaggt ggggcgaggc gggccgcttc atgccgacgg acaggtggac catgctcatc
     1801 gagtcctcga cggaggtgct ctgcactccg gcccgctggt ggtccctctc ggtgcggccg
     1861 aggcagggca ggatcagggc ctgccggccg tgcaccaggt ggctgcggtt gagcttggtg
     1921 ctgacctgca cggtcagttc cgtgcggcgc agcgcctcgt gggtgtacgg ggtgtcgggg
     1981 gcggccaggg cgaagttgcc gcccatgccg acgaagacct tgacgtcgcc gcggtgcatg
     2041 gcctcgacgg tgccgacggt gtccaggccg tgggcgcgcg gcgggtcgat gccgcacacc
     2101 tcggcgagcc ggtcgaggaa ctcctcggcg gggcggtggt cgatgccgca ggtgcggttg
     2161 ccctggacgt tgctgtggcc gcgcacgggt gaggggccgg cgccctcgcg gccgacgttg
     2221 ccgcgcagca gcaggaggtt gacgatctcg cggacggtgt cgacgccgtg ctcgtgctgg
     2281 gtgacgccga ggcaccagct gacgatggag cggtcggcgt cgcggtagat ccgggcggct
     2341 gccaggattc cggcgcgcgg gacgccggac tgctgctcga tctcctccca ggaggtggcc
     2401 tcgcaccggg cgcggtactc ctcgaagccg ctggtgtggc ggtcgacgaa ctcccggtcg
     2461 agtgccttgg ggtcggagcc ggacagttcg aggatcgcct tcgcgatgcc gcgcagcagg
     2521 gccatgtcgc cgccgatccg cggctgcagg ttgagggtgg tggtcgcggt ggggtggaac
     2581 agcgccatgt cgacgaagtc gtgcgggacg atggtgcggg tggcggcggc ctcgaccagg
     2641 gggttgatgt gcacgatccg ggcgccgcgg cggtgcgcct cggcgagggc ggtgagcatt
     2701 cggggcgcgt tggaggcggc gttgacgccg atgatgaaca gggcgtcggt ggtctcccag
     2761 tccttgaggt cgacggtgcc cttgccggtg ccgagcgacg cctccatggc gcgtccgctc
     2821 gcctcgtggc acatgttgga acagtcgggg aggttgttcg tgccgagctc acgggccatc
     2881 agctggtaga ggaaggtggc ctcgttgccc agccggccgg aggtgtagta ggcggcccgg
     2941 tcggggctgt ccagttcgcg cagggtgcgg ccgacgagtg cgaaggcgtc cttccaactg
     3001 atcggcacgt agtggtcggt ggcggcgtcg tagaccagcg gcccggtcag gcggccctcg
     3061 ttctcgaggg cgaagtcgga ccactccatg agttcggtga cggtgtgggt ggcgaagaac
     3121 tccttgccgg cgcgcttgcg ggtcatctcc caggtgacgt gcttgatgcc gttctcgcag
     3181 atgtccaggt gcaggccctt ggtgtcgtcg ggccaggcgc agccggggca gtcgaagccg
     3241 gtgttctcgt ggttcatccg caggatcgcg cgcgggccgt cgacgagggc gccttcgcgg
     3301 acgaggaccc ggctcacgct cttcgcggcg ccccagccgg ctgccgggtg gtggtagggc
     3361 cggaactccg gccggttccc gggggtcgga ccggacccgt tcccggcgcg gtggccgttt
     3421 gccccggcgg caccctcggt ggtgccggtg tccgtcgcga gcggtgcgtc gtcgttgcgg
     3481 tcggaggcgt tcacggcact cacccttcgg cgtcggaccc cctggcgtcc ggcgccgggg
     3541 cctctgcggg cgcgggccga cgcccgctgc ccaggctatg cccggggggc ggggtccgcc
     3601 cgcggcgccg gggcgcgggc ctgcggccgt cgtccggccg gtccggcggg gtcccgttag
     3661 ggtggcagga gttgtgtcca ttgtgagatg aagcgagtga tttccatggg tttgcccccc
     3721 gtggagggtt tcggctcctt cgggtccgcg gatcccttct ccgacctgct caaccgcttc
     3781 ttcggcatgt ccgcggcgtc ctcaccgccc gcggtgcagc gcgtaccgat cgggcggctg
     3841 ctcacggcgt cctcccgggc gctgatcgcc cgcgcctcgc agcgcgcgac cggggacggc
     3901 agcaaggacc tggacaggga agggacggga ggaccttgga cgtgaccggg gacatggagg
     3961 cgcccacccc gcagccggtg ctcggcccgc tgaccaccgc atcgctgttc ctcgtactca
     4021 ccgtcgaccc cggcggcgag cccgtggtgc gcgagctgct ggccgacctg gcgggcctgc
     4081 ggcgcagcgt cggcttcggg caccccgacg ggcggctcag cgtcgtcgcc gggatcggct
     4141 cggcctgctg ggaccgcctg gtggagggcc cgcgcccggc cgggctgcac cccttccggg
     4201 agctgcgcgg tgtccgccac cgggccccgg ccaccccggg cgacctgctc ctgcacatcc
     4261 gggccgcccg gcaggacctc tgcttctcgc tcggctcgga gatcatggcg cggctgcgcg
     4321 gggccgtcgc ggtggcggac gaggtcaccg gcttcacgta cctggaccag cgcgacctgc
     4381 tcggcttcgt cgacggcacc gagaaccccg tcggccgggc ggcggccgag gccgtgctga
     4441 tcggcgcgga ggacccggac ttcgccggcg gctcctacgt gatcgtgcag aagtacctgc
     4501 acgacctcga cgcctggaac cgcctgccgg tcgagcagca ggagcggatc gtcggccgcc
     4561 gcaagctcac caacgtcgag atcgactccc ccggctcgca cgtcgacctc aacacgatca
     4621 ccggccccga cggcggggaa cggcagatcc tgcgcgacaa catgcccttc ggcagccccg
     4681 gcggcggcga gttcggcacg tacttcatcg ggtacgcgcg gacgccggag gtcaccgagg
     4741 agatgctccg ccacatgttc ctcggcgacg ggccggtgag ccacgaccgc atcctcgact
     4801 tctccacggc cgtcaccggc acgctgttct tcgtgccctc cgccgacctg ctggaggacc
     4861 tgggggccga ggaggactcc ggtgccggcg aacgggggtc gctcggcatc ggcgacctca
     4921 ggaaccgctg acagcaccga ccgcacggtc ggcgccggag cagtgctgcc ggcaccgacg
     4981 caggcgacag gagacccggc atggacaacc tgcaccgcga actcgcgccc gtctcggccg
     5041 cggcctgggc cgacctggag caggaggccc ggcgcacctt cacccggcac gtggccgccc
     5101 gccgcatcgt ggacgtcccg gaggccggcg gcacggagct ggccgcggtc aacaccggcc
     5161 ggctggacga gatccgctcg cccgaccccg gggtgcgggc ccggctgcgg caggcgcagt
     5221 cgctggtgga gctgcgggtg ccgttcaccg tggaccggtc gcaggtggac gacgtcgccc
     5281 ggggtgccga ggacgcggac tggggtccgg tgaaggaggc cgcccggcgg atcgccttcg
     5341 ccgaggaccg cgccgtgttc gagggctacc cggcggccgg catcgcgggt ctgcgggcct
     5401 gctccgccaa cgaggcgctg accctgcccg ccgacccgcg cgactacccg accgtgatca
     5461 gccaggcgat cggcgaactc cggctggccg gcgtcggcgg cgcctacacg ctcgccctga
     5521 gcgcggacgc cttcaccgcc gtcagcgaga cctccgacca cggctacccg atccacgagc
     5581 acctgcgccg cctcctcgac ggcgagatca tctgggcccc cgccatcgac ggcgccttcc
     5641 tgatctccac ccgcggcggc gacttcacgc tccggctcgg ccaggacctg tccatcggct
     5701 acctcgcgca cgacaccgac accgtcgagc tctacttcca ggagtcgctg accttcctcg
     5761 tccacaccga ggaggcggtc gtcccgatca accccgcccc cgcggcccga tagcccggcg
     5821 gtgcacgggc cgggctgcgg cctgcggtca ccgcgcggtc gtccgccccg gttcgatgcc
     5881 gcaggagttc gcagaagcgg ccagggcgcg gtcggtgccg cggcggtcgc cccgcggcgc
     5941 ggacggtggt gaccgtcggg tccgatccgg catcccatca gcgcgttcgt cccggaccgg
     6001 ccggtcggcc cgggaaccgg cccaccgggg gccttcgtcg acccggcgat gccgagcagc
     6061 agctccgccc cgcctggaag accggatccg gcaccgactg aatgccgccc gatcggcgtg
     6121 gtgccgcggt cccgttcgag cacgtgacct ccgcccgggc gcagtcgacg ccggcccgac
     6181 cgtccggacc acgatcgacc gccggagcac cgatgcctcc gggtctgccc cgcccccggc
     6241 cggagcagac ccgtgcccgt ggtgtcagtg ttcggcaggg gccgccggga ggctgcgcag
     6301 ccggacgacc ggggaggccg ggagcgcgag gacgacgacg gcggagccgg ccgcggcgac
     6361 ggccagggcg gcgcgcgcgc cgaggtgtcc ggccagcagg cccgcgccga ggccgccgag
     6421 tgcgccgccg ccgaagagca gggtgcggaa ggccgcggtc atccggccca tcatcggctg
     6481 cggggtgacg gcctggcgga ggctgacgat gatcactccg gcgatgccga gcccgaggta
     6541 ggtggtgagg aaggagagca cgaacatcgc cgtcatgacc gggcgcggcc cggtggcgca
     6601 cgggatgagc acggggccga gcagcagcgc cgactgggcg accaggtaga cgcggccgag
     6661 cgggaagcgc tcgatcaccc ggcgcgagag gacggcgccg agcaggccgc cggccgaggc
     6721 ggtggcgaag acgccgccca gtgcggtgga ggacagccgc aggtcgtggc tgccgtacag
     6781 caggaacatc gtccacaccg tgaccatgga gaagttgcag cagaacccga tcagggcgag
     6841 cgcccgcagc accccgttgc gcagcacgaa gccaaggccg tcccggagtt cgcggagcag
     6901 gtgccgttcg gcgggccgct cggggcgcgg ttcgggggtg cggatcagca gcagcgaaac
     6961 gacggagacc gcgtacgagc atgcgtcgac gaccagcgcg gcgggcgcgc cgacggcgga
     7021 gaccagcacg cccgcgaggc ccggcccggc cacgtccgcg gcggaggagg aggcgctcat
     7081 ccgcgcgctc gccgccacgt actgcctgcg gtcccgcacc agcagcggca cgtaggacat
     7141 ccagctgacg tcgaacacca ccgaggcggt gcccacggcg caggcgatca ccatcagcac
     7201 cgtcaggtcg agcgcgtgcc accagtacag cagcggcacg agggcgagca gcaccaggcg
     7261 gaccaggttg gcgccgagca tcacggggcg gcgccgggcc cggtccgccc agacgccgat
     7321 caccagcgcg aggccgaggt aggggacgag ttgcaggaag cgcagcaggc cgacctgctc
     7381 gtcggtggcg ccgaaggcgt cgatggcggt gagcggcagg gcgagcgcgg tgacctgggt
     7441 gccgagcagg gagaccgtct cgccgagcca gaaccggacg aagtcgcggt tgtgccacag
     7501 gctcggcggg gtagcgcggg tcgcctgcac cggggccgcg ctgccggatg agggcgagag
     7561 ggcggtcatc gcaggccctc cgcggcgagt tcggcgaccg ccccggccac ctcggcgacc
     7621 tcgtcctcgg tgttgtagta gtgcggcgac agccgcaggc accactcgac ctccttgtcg
     7681 cggaagtcga actgggcgaa ctcccggaag ctcagcgccg agttgatgcc tcggcggtcc
     7741 agggccgcct tgaacggatg cggctcccag ccctcgacgg cgacggtcac cagcgcggcg
     7801 ggcgccggcc cgcggtcgag ggtgcggaca ccgggcacgc cggcgagccg ctcgcgcagc
     7861 agggcggcga gcgcgggggt gcgtcgggcc accgcgtcct ggccgaccgc cagcgcgtag
     7921 cggacggcgg ctgcgcagcc gaggacggtg gcgtagggga actcccactc ctcgaagcgg
     7981 gcggcggtgg ggacgggccg gtagtggccg ggggcgaccc agcgggcgcc gtgcatgtcg
     8041 atgtacagcg gctcgccgcc ggcctgcagg acgcggtcgg agacgtagag gaagcctgaa
     8101 ccgcggggcc cgcgcaggaa cttgcggcag gtggcggtga gcaggtcgca gccgatctcc
     8161 tcgacgtcga tccggtactg gccgaccgac tggcaggcgt ccacgaggta gagcaggccc
     8221 agttcccggc agtgccggcc gatctcggcg accggctgga ccaggccgga gttggtgggc
     8281 acgtgggtgg cggcgaccag cctggggcgg tgggcgcgca tcagggcggc catcgcctcg
     8341 acgtcgacgc cgctgccgtc ggggcggtcg ggggcgtgca cgatccggac gccgtgccgg
     8401 cggcgcagcg agaggaaggc gatctggttg gagacgaagt cgttccgggt ggtgaggacg
     8461 gtgtcgcccg gtcggaagtc gaacgaggag agcgccttgg tgtaggcgtg ggtggcgctg
     8521 gcggcgaagg cgatgttgcc ggggcgggtg ttgagcaggc cggcggtggc cgcgtagaag
     8581 tcggcgatct cggcggtgcg ggcggcggcg gcctcgtagc cgccggtggc ggcctccagc
     8641 tccaggtgtt cgaccaccgt gcgcagcacc ggacggggcg tcagtccgca gccggcgttg
     8701 ttgaagtgga ccacggaggc gcagccgggg gtgtcggccc gcagggcggc gatgtcgagg
     8761 agcggttccg ggccgatggc gaaagcgcta ttctgtgtcg tcatgaatga cggtagcagt
     8821 actgaggccc tgctggcgat cctccgtacc gagatcgccg ccctggctcc gggcgaccgc
     8881 ctgcccagca gcagggatct gatcgcccgt cacggcgtcg ggccggtcac ggtctcccgt
     8941 gccgtcgccc agctcgcggc cgagggcgtc gtcgtcaccc ggcccggcag cggcacctac
     9001 gtgacggcgc gccggaccgc gggctccgcg gccccggaca cctcctggca gtccgtcgta
     9061 ctggcggacc gccggatcga cgccgccgag gaggagacgg ccctgccgga gctcccgccc
     9121 ggcaccgttc cgctctccgg cggctacctg cacgagagcc tgcagcccgg ccggatcctc
     9181 ggcgcggccc tcgcccgcgc cgcccgccgc ccggacgcct ggcaccgcgc gcccgccgcc
     9241 ggcctcgcca ccctgcgtgc cctgttcgcc cgccagaccg gcggcgacca cgggcccgag
     9301 gacgttctcg tcaccgccgg gggccagagc gccctgtcca tgctcttccg ggccgtcgcc
     9361 gcgcccggcg cgcccctgct cgtcgagtcg ccgacctacc ccggcgcgct ggccgccgca
     9421 cgtgccgccg gactgcgccc ggtgcccgtc ccgatggacg accgcggcct gcgccccgac
     9481 ctgctcgccg acgccttcgc gatgaccggc gcccggctgc tctactgcca gccgaccttc
     9541 cacaacccca ccggcgtcgt cctcgccccc gaacggcgcc gccaggtcgt cgacgtggcg
     9601 cgggccgcgg gcgccttcct gatcgaggac gacttcgcac gccacctcgg ccacggccgc
     9661 gccgtccccc gcccgctggc ggccgacgac cgcgacggca ccgtcgtcca cctcacctcg
     9721 ctcagcaagc ccgcctcgcc cagcctgcgg atcggcgcga tcaccgcccg cggaccggtc
     9781 gtacggcggc tgctgagcct gcgccgggcc gacgacttct tcctcgcccg gccgctccag
     9841 gaggccgccg tcgaactgct ctccaccccc gcctgggacc gccacctgcg cggactcggt
     9901 accgcactgc ggcagcgctg cgccgtgctc gcccacgccg tcgcccgcga actcccggac
     9961 tggacaccgg ccccgacccc ggagggcggc ctccacctgt ggctgcggct gccgcccggc
    10021 ccgaccgagt ccgccctcgc cgacgcggcc cgcgcgcacg gcgtcgccgt cgaccccggt
    10081 caccggttct tccccgccga accgaccgcc gcccacgtgc ggctcgcctt cgccgccgcc
    10141 gcggagcccg ccgacctcgc cgaggccgtg cgccgactcg ccgcggccgc ccgcagcggg
    10201 gcctgacgtc gcggggccgg tcctccgcga cccggccgcg gggccggtcc tgcccgaccg
    10261 gcccggtcgt cgaacgcggc cggtctcagg acgcggcgct ctccgccgcg atcatcgcga
    10321 tcagtccggc cctgccgtgc tcggcgaggt ggcggcgctg ccgttcggcg ccgttgccct
    10381 cccgcagcag ccggccgacc agcggggcca ccgcgcgagt gtcaccgagc tcctccagcg
    10441 cccggcggag gtgttccagc atgtcggcgg cgaccttgcc ggcgggccgg gacagcccgg
    10501 tcgccgggtc gtgcagggtg ccgtccatgc cgtaccgggc ggcgtgccag gccgcgccct
    10561 ccaggctctc cggcgtccgc ccgtccgggg ggactccttc ggccgcgtcc cgcatcgccg
    10621 tgacggccag cgcccggacc agcccggcga gcatcaccgc ctcgtcggcg cgcagctgga
    10681 catccatcgc gcgcagctcc atggtcggga acttggccga cagccgggcc tgccagtaca
    10741 gctggccgcg gtcgcggatc agccgggcct ccaggaggtg gtcgatcctc cgctcgtagt
    10801 cctgcgcgtc ggc
//
