LOCUS       NZ_CP106798            22068 bp    DNA     linear   CON 01-NOV-2023
DEFINITION  Streptomyces sp. HUAS 15-9 chromosome, complete genome.
ACCESSION   NZ_CP106798
VERSION     NZ_CP106798.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. HUAS 15-9
  ORGANISM  Streptomyces sp. HUAS 15-9
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9258818)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 169.8x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/01/2023 03:42:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,774
            CDSs (total)                      :: 8,679
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 95
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 504
            CDSs (without protein)            :: 504
            Pseudo Genes (ambiguous residues) :: 0 of 504
            Pseudo Genes (frameshifted)       :: 260 of 504
            Pseudo Genes (incomplete)         :: 328 of 504
            Pseudo Genes (internal stop)      :: 29 of 504
            Pseudo Genes (multiple problems)  :: 107 of 504
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:51:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7366659
            Orig. end                         :: 7388727
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106798.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="21"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22068
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12068](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12068
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    105..114
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(571..585)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    572..586
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     misc_feature    579..596
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    715..729
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.9"
                     /tool="antismash"
     gene            775..2247
                     /locus_tag="N8I87_RS33670"
                     /old_locus_tag="N8I87_33670"
     CDS             775..2247
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019985189.1"
                     /locus_tag="N8I87_RS33670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33670"
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="WP_263214464.1"
                     /transl_table=11
                     /translation="MRHPPRSLLLAVAGAVALVGTALAPVVSASGATPACTVEYSVTGQ
                     WDTGFQGAVKITNNTAALSGWSLTFDFANGQKVTQGWSAKWSQSGTTVTTANESWNGSL
                     GTGASVSAGFLGSWSGSNAVPTAFKLNGTTCNADAEPSPTPTEPPPGNGNAPALHVLGN
                     KLVDADGKTRRLLGVNRSGGEFMCVQGYGIWDGPVDDAAIKAIADWKANAVRIPLNEEC
                     WLGLSNIKPEYAGANYINAVKDLVARVEAHGMTPVLELHWSYGQYTGNSAGCSDVHASC
                     QKPMPDMQYSPSFWSSVASTFKSDPAAVFDLFNEPYPDRATSTTTQAWQCWKDGGNCPG
                     ISYEVAGMQDLVDAVRGTGAKNVIMAGGLAYSNDLSQWLTYRPTDPAGNLVAAYHVYNF
                     NTCANESCWNSTLAPVAAQVPLVAGEVGENTCSHAFVDRVMKWFDDRNLSYLGWTWNTW
                     DCSSGPSLITGFDGTPTAYGIGLRDHLRAINP"
     misc_feature    792..807
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    802..804
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2274..3995
                     /locus_tag="N8I87_RS33675"
                     /old_locus_tag="N8I87_33675"
     CDS             2274..3995
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007504765.1"
                     /locus_tag="N8I87_RS33675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33675"
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_263214466.1"
                     /transl_table=11
                     /translation="MSRTRTAVLAALALVAGASGTALTTAPANAAASAVPCTVDYKVQN
                     QWDTGFTAAVTVTNNGAAKSGWSVKWAYSGNQKVTNYWNTKLTQSGSAVTADNETYNGT
                     LATGGSVSFGFNASYSGGNAIPTAFTLDGVTCNVDDGGSGGGGGGGGGGGTGSRVDNPY
                     AGAKVYVNPEWSAKAAAEPGGSRVSNQPTGVWLDRIAAINGVNGSMGLRAHLDAALAQK
                     GSNEEVVQLVVYDLPGRDCAALASNGELGATEIDKYKTQFIDPIAAILSDSKYASLRIV
                     TTIEIDSLPNLVTNTGSRATATPACDTMLANGNYVKGVGYALAKLGAIPNVYNYLDAGH
                     HGWLGWDDNFGPAATLFKQAATSEGATVDDVAGFITNTANYSALKENNFTVNDTVNGTS
                     VRQSKWVDWNRYVDEQSFAQAFRNQLVSVGFNSGIGMLIDTSRNGWGGTARPAGPGPQT
                     SVDTYVDGGRYDRRIHVGNWCNQSGAGLGERPQAAPATGIDAYVWMKPPGESDGSSTAI
                     ANDEGKGFDRMCDPTYTGNARNGNNMSGALPNAPLSGHWFSAQFQQLMQNAYPPLP"
     gene            complement(4020..4790)
                     /locus_tag="N8I87_RS33680"
                     /old_locus_tag="N8I87_33680"
     CDS             complement(4020..4790)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073100.1"
                     /locus_tag="N8I87_RS33680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33680"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_263214468.1"
                     /sec_met_domain="PhyH (E-value: 3.1e-07, bitscore: 29.8,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDEMVQRFIEDGFVKIEGAVPKRVTEHCARLLWRETGYDPDDPG
                     TWKDPVVWVGGMAQGPFAAAANSAVLHEAFDLLVGERRWAPRYSLGSFPLRFPHAEEPD
                     DAGWHIEGSYLPEGADQWHTNLLSRERALLMLFLFSEVTEADAPTRIRVGSHLDVPPVL
                     EPYGAAGASFLELGPQVAAASAHRPLAYATGSPGDVYLCHPFLVHAAQPHHGTRPRFMA
                     QPPLHLESPLELDRADGDHSPVELAIRRGLSPQG"
     gene            4915..5802
                     /locus_tag="N8I87_RS33685"
                     /old_locus_tag="N8I87_33685"
     CDS             4915..5802
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004980962.1"
                     /locus_tag="N8I87_RS33685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33685"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_263214471.1"
                     /transl_table=11
                     /translation="MAHHHQHGHGHDHADTDIDWAAMAPHLEAQAELLAPVYERAMAWL
                     AKEVTEPGLIVDAGSGPGVVSCLFAEAFPGARVMAVDATEPLLERARDRAARQGVGDRF
                     GTLAGELPGVLEELDYPADLLWASRSLHHLGDQRAGLAAFAARLAPGGTLALLEGGLPS
                     RFLPRDIGVGRPGLQARLDVVEEEWFARMRADLPGAVAVTEDWPALLAAAGLKHTRTRS
                     FLLDLPAPASDRARAYIAATLSRVREAAADALDTEDHATLNRLLDPSDPASVHRRPDVF
                     VLSAYTVHTAVRPV"
     gene            5883..6224
                     /locus_tag="N8I87_RS33690"
                     /old_locus_tag="N8I87_33690"
     CDS             5883..6224
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N8I87_RS33690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N8I87_33690"
                     /product="hypothetical protein"
                     /protein_id="WP_263214473.1"
                     /transl_table=11
                     /translation="MSRQAPAATAGVTSPDGRRLAVADYRGRLTLWETAQPRLGPAILP
                     AGDGPVLAVGFGPDGAELHLAPHLPERVGSLVTDRAVTEVRSRANGRATEAEWRRQLPS
                     VPYRCTCVA"
     gene            6283..7019
                     /locus_tag="N8I87_RS33695"
                     /old_locus_tag="N8I87_33695"
                     /pseudo=""
     CDS             6283..7019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922768.1"
                     /locus_tag="N8I87_RS33695"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33695"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTDSPVALITGGDGGPPARAKPRVGEASVPPLPGSCWTPGTGSPS
                     PGGASRGCARSERGSASRTGC"
     misc_feature    6307..6321
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     gene            complement(7080..7775)
                     /locus_tag="N8I87_RS33700"
                     /old_locus_tag="N8I87_33700"
     CDS             complement(7080..7775)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073097.1"
                     /locus_tag="N8I87_RS33700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33700"
                     /product="glycoside hydrolase family 75 protein"
                     /protein_id="WP_263214474.1"
                     /transl_table=11
                     /translation="MRVRTLTLAAASGAALLAAGVLPASASGSTTPRSTQEGSVSAADL
                     LAKVKSCSQISNGKYKTDDETSATVPVCGKNGAVFWKADMDIDCDGQRTTNCNEDRDPW
                     YQDDTAFHQSNGKPLKAESLPYVVVPSSSGIWNYSSAGIKGGGVVAVIYNNKVEYAVVG
                     DTGPTKIIGEASYATAKALGIDPDPATGGVDSGVTYILFKNSKVSPIESHSAAVTLGDQ
                     LAKQFLQNN"
     misc_feature    complement(7863..7876)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.86"
                     /tool="antismash"
     gene            7980..8591
                     /locus_tag="N8I87_RS33705"
                     /old_locus_tag="N8I87_33705"
     CDS             7980..8591
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676057.1"
                     /locus_tag="N8I87_RS33705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33705"
                     /product="hypothetical protein"
                     /protein_id="WP_263214476.1"
                     /transl_table=11
                     /translation="MFVRTVYVTGDPTKIDTAIRALNTEGRDLLEERPGYRGAGVFVDR
                     ELGKLFSTSWWSSEEARHNSDEVMRERRGALLEPFAGTVAVDNYEVAVYHAQQMPRTAG
                     GLRITRLEFEPADTDLVADTFRASVLPRLETLHGLARASLFVDRDRGSGMVHILFVDHG
                     SMAASRSAQAMARHEGTAKAHVTVTGLEEFEVVHADVHPD"
     gene            complement(8694..9530)
                     /locus_tag="N8I87_RS33710"
                     /old_locus_tag="N8I87_33710"
     CDS             complement(8694..9530)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191514.1"
                     /locus_tag="N8I87_RS33710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33710"
                     /product="aldo/keto reductase"
                     /protein_id="WP_317633513.1"
                     /transl_table=11
                     /translation="MSSKVPPIILNNGVEMPQLGFGVWQVPDDEAERAVATALEAGYRS
                     IDTAAIYGNEEGTGKAIAASGLPREDVFVTTKLWNSDQGYDATLRAFDVSLDKLGLDYL
                     DLYLIHWPLPSRGTYIETYKAFEKLLAEGRVRAIGLSNFLPEHLERLLAETSVIPAVNQ
                     IELHPHLQQHAARAFHAEQGIHTEAWSPLGQGKGLLEVPAIVAIAQKHNRTPAQIVLRW
                     HLQLGNIVIPKSVTPSRIKENIDVFDFSLDAEDLAAISALNEDRRLGPDPATFEMG"
     misc_feature    9678..9693
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    9753..9768
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 20.79"
                     /tool="antismash"
     gene            9837..9977
                     /locus_tag="N8I87_RS33715"
                     /old_locus_tag="N8I87_33715"
     CDS             9837..9977
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669248.1"
                     /locus_tag="N8I87_RS33715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33715"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_263214478.1"
                     /transl_table=11
                     /translation="MNETLPEARQAEQTVQETSDENGWQSPGYTVVETALEVTAYALGD
                     R"
     gene            10001..10738
                     /gene="pqqC"
                     /locus_tag="N8I87_RS33720"
                     /old_locus_tag="N8I87_33720"
     CDS             10001..10738
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433953.1"
                     /locus_tag="N8I87_RS33720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33720"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_263214480.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.1e-82, bitscore:
                     276.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPVRADGTAPPWPAAEFTRRLCAVTAERYHDRHPFNLRMHRG
                     ELTPGELRRWIANRFHYQRHIPVKDALVLAKLDRPALRRAWLRRIRDHDGTAEGEGGIE
                     RWLRLGEAAGLTRDELWDTSQVLPGVRHAVERYVSFCRRRPALEAVAASLTELSAPDLM
                     RIRIAAFERHYPWIDPSGLAYFRTRVGQGARDGEEALALVHAWARTREQQERAVAALVF
                     KCDVLWELLDSVDRGDSVAGGGP"
     gene            10735..10989
                     /gene="pqqD"
                     /locus_tag="N8I87_RS33725"
                     /old_locus_tag="N8I87_33725"
     CDS             10735..10989
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645346.1"
                     /locus_tag="N8I87_RS33725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33725"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_263214481.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.5e-17, bitscore:
                     61.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-07, bitscore: 30.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWRPVLSRGVVLRHDRVRCTDLLLLPERVVVLHGRAGGVLRLCD
                     GSREVREIVAELRAGYPGAPVAAEVPYFLAALRKEGWLT"
     aSDomain        10744..10986
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_N8I87_RS33725_PqqD_RRE.1"
                     /evalue="8.50E-20"
                     /identifier="RREFam006.1"
                     /label="N8I87_RS33725"
                     /locus_tag="N8I87_RS33725"
                     /protein_end="84"
                     /protein_start="3"
                     /score="61.3"
                     /tool="antismash"
                     /translation="RPVLSRGVVLRHDRVRCTDLLLLPERVVVLHGRAGGVLRLCDGSR
                     EVREIVAELRAGYPGAPVAAEVPYFLAALRKEGWLT"
     gene            10986..12068
                     /gene="pqqE"
                     /locus_tag="N8I87_RS33730"
                     /old_locus_tag="N8I87_33730"
     CDS             10986..12068
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433951.1"
                     /locus_tag="N8I87_RS33730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33730"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_263214483.1"
                     /sec_met_domain="PF04055 (E-value: 4.5e-23, bitscore: 81.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.6e-06, bitscore: 26.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-08, bitscore:
                     34.0, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPDPPWALLAELTHGCPLRCGYCSNPVELVGRSEELTAQQWMGV
                     FRQAAALGVVQTHLSGGEPLLRRDLPDIVAAADTAGLYTQLVTSGLGLGERRLAALVDA
                     GLRSVQLSVQHADPAASERIAGARSFVAKERAARLIRAAGVPFGVNVVLHHGNLDALDD
                     LIALGVAWGVDRIELANTQFHGWALRNRTALLPTPEQTRRAHDTVADWRQRLRDGPELV
                     WVAPDLVDATAKPCMGGWGRVSLTVAPDGTTLPCPAAAALPGLDPPNVKDRPLDWIWRR
                     STAFNAFRGESWMREPCRTCALRTTDHGGCRCQAYALTGDAARTDPACRHAPDHHLVRD
                     LVRLADADRDLAYAYREGGP"
     gene            12065..13248
                     /locus_tag="N8I87_RS33735"
                     /old_locus_tag="N8I87_33735"
                     /pseudo=""
     CDS             12065..13248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119200.1"
                     /locus_tag="N8I87_RS33735"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33735"
                     /product="glycoside hydrolase family 88 protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRRRRLRAALTALALTTGGLAALPAAVPRPSPPPPRAGRPPPPTG
                     PRPWSTPPWTATHRPPSAAGRTRWASTSTASTSPTGAPTTRATSPTSRAMSTAS"
     gene            13253..14092
                     /locus_tag="N8I87_RS33740"
                     /old_locus_tag="N8I87_33740"
     CDS             13253..14092
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073094.1"
                     /locus_tag="N8I87_RS33740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33740"
                     /product="polysaccharide lyase"
                     /protein_id="WP_263214488.1"
                     /transl_table=11
                     /translation="MSTSRWGTARRAVLGAALGGAATAAVGLPASRASAASWQLKWSPS
                     ASRDGLGAFETVEDDRADSHPAGHPHIHPTGDNWRFTMHKVDRDTSTDRQRQEVTGLRT
                     SGSGYLKWTQGQTWRITYSMYIPSSLKATTTFTHIMQMKQPGNGTSPIVVQSLRRDGGT
                     SLLERSRELGGGVQTIELRLAIDDILVGRTDLAPLHDKWTDVDFQIKVGNGSAGSVRWI
                     LKSGSTTVVDKARTGVDTFLADRVRPKWGIYRSLGDTSGSLQDTYLLLTDLRGYQLL"
     gene            14104..19500
                     /locus_tag="N8I87_RS33745"
                     /old_locus_tag="N8I87_33745"
     CDS             14104..19500
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141318.1"
                     /locus_tag="N8I87_RS33745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33745"
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_263214489.1"
                     /transl_table=11
                     /translation="MRSTTPHRRGAAAIVLSVLAVVLGLAHPAALAAPQQPHRAAAVYD
                     VRDYGAKGDGSANDTPAVNKAITAANSAGGGTVRFPAGTYRSKNTIHMKSDVTLQVDTG
                     ATIQGSSADTYDPPESNPYDKYQDYGHSHFHNAMIYGDRLTDIGFVGGGVIDGAGNLIT
                     GNPKSGEADKIISLTRCDGLRLGDGLTLRRGGHFAALVNGCKHVTSDRLTIDTASDRDG
                     WNIISTTDVTVTRADIKANDDALVFKSDYALGAKLPNGHVRVRDSSLSARCCNALMFGS
                     ETCGDFTDYQFEKIRIEGADKSGLGMVSMDGAKISDVHYRDITMTDVHSPIMEKIGTRK
                     RCGDSPGVGSISNVTYDNITATGSGPSFSPTLWGENGHRINGITFRHVDITVPGGNGTM
                     STGVPGNDPKDYNPKAIGTRPAYGWYLHNADDVTFTDSSVKFAANDGRPAVIANAASNI
                     RFTRFTAQRGSNSPHDTGFQSVSGYCLTDSHNTSGGALRTSSTGSTENCGAQARPLDLD
                     NPRQDFLRNSVGGLFLHWGLRTAPAHTNCGAWENDVTSGGWTPDYWVNEARKLHTQYLV
                     LATFHSRLGYARPWPSRIPGSCSTKRDFLGELITAAKAKGMKVILYMTDDPQWHDEGGH
                     EWLDSAGYSAYKGKNVDLTTRDGFGQFSYDNFFEVMDRYPDLGGFWIDNDNAYWESHNL
                     YAQIYRKRPNYTLSNNNEDTPIMDMISNEQKTGMTPAYDYPQAVYTAQPRLTEADFKLP
                     SAGAWWYDGSDPSVDRKLTLGRLVTNAGSSVKALMAETAQVDGRFPANQAAFNTFANTY
                     LDPIWESLHGTEGGGYLYGGLKPGFWNDGAHGVTTISRTDQNRQYIHVLTPPSTSTLRI
                     RDNGYRITSVTDLRTGAAVSWSQSGGVLRLTGLGTWDPYDTVFKVTTAGRQGILKGVKV
                     SASASASGHTGSAAGDGDHLTYWDNDKTLPVDLTFDLGTAKKVRYIGLNQREDSVAYAR
                     SATEQSARIKDYKVFLSNDGSTWGSAVKTGQLPSRRGIQGIDLTAANARYVRLEVDSTW
                     AASTDTTRYKRLRIDEAWIGTAYATPADLTTKSDNGQSLRPAMGWSSWSFVRRWPTEAK
                     IKAQADALVASGLKDHGFVQVNLDDFWQTCDSNGFVVDSYGRWTVNAAKFPSGIKALAD
                     YVHSKGLKFGFYVTPGIAKNAVTANTTIEGTPYHAKDIADTSKTEKNYNCKNMYYIDYS
                     KPGAQDFINSWARQFASWGVDHLKIDGVGSQDIPDVQAWDKALRATGRPITFALSNNLP
                     IANAVTWRKLANSWRTQGDVECYCGPGANGSGYPLTDWSHVSARFTSAADWQPYAGPGG
                     WNDLDSLEIGNGDQVGLTADQRRSHFTLWAMAGAPLLLGTDLTHLDSVDKAMLTNDRLI
                     GVDQDGVAAKRLVNSGVKQVWSKRENSGDYVVALFNTGTSGRATVSVNWSHVGFTGSGD
                     VTDLWSGSHKGVIADSYSATLRPGETRLIRVEPAASTRSAAASPGFAVAPYEYLGWGNP
                     PSPTSVMSATGVKWFTLAFVLSDGTCNPKWDGSRPLTGGNDQSKINAIRAAGGDVIVSA
                     GGWSGAKLGEKCAGASALAGAYQKVINAYRLKALDIDIENTEWASATVRQRVVDALKKV
                     KADNPGLKTVITFGTTTSGPDSTGVDMIKRAAASGLVNDVWCIMPFDFGGGTTDMGTLT
                     TRAMEGLKARVKSAYGYGDATAYAHIGLSSMNGKTDDSGERVRVADFKTMLAYAQQHHI
                     GRLTYWSVNRDRACGSGTDGDSCSGVSQQPYDFLKVFAQYTG"
     gene            19512..21542
                     /locus_tag="N8I87_RS33750"
                     /old_locus_tag="N8I87_33750"
     CDS             19512..21542
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073092.1"
                     /locus_tag="N8I87_RS33750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_33750"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_263214491.1"
                     /transl_table=11
                     /translation="MNLKRVLPYGLTVALALPLAGLSQGTALAATDYQAEDALISQGTV
                     ATNHTGYTGTGFVDYTNVKSSYVEFTVNAAAAGTSSLTLRFANGTSTDRPMDISVGGTV
                     VASGVSFPATADWNTWTTRSVNVPLAAGTNKIRATATTANGGPNLDRVSLAAAADSQAP
                     TRPGRPSCSDIGENGLTLGWGASTDNVGVAAYDIYEHGNKISEAPGSATSKALTGLTPN
                     TTYNLTVIARDAAGNTSPASPVVDCTTKPSSDTTPPTAPGTLSTADVTANSVGLSWGAS
                     SDDRGVTAYDIRSGSTVYKTVTSGTTTTLTGLACDSPYSLNVVARDAAGNVSPPGNTVT
                     FTTKACATDGGVPSSIGTLSTGWTIPWGTYWLPDGKSALVTERDDFRVRRLTKDGTKTE
                     VGTVPNVVTTNGEGGLLGVAVDPRWESNHYVYFMHTASEGNRVVRMTYNGSSLSNYTVL
                     LQGIKKNRYHNGGRLAFGPDGYLYVSTGEAQTPDLAQDKNSLNGKILRMTTDGKPAPGN
                     PFGNYVYSYGHRNPQGLAFDRNGRLWEAEFGNSSKDELNLIKPGANYGWPTCEGSCSVS
                     GMTNPKATWNVSEASPSGIAIVRNVVYMASLRGERLWRIPIDGDNESVGTPTAYYVGTY
                     GRLRTVTKVPGSDQLWLSTTNCDNNGGAADGSDKIFRVTIG"
     misc_feature    21678..21692
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
ORIGIN
        1 agcggtacgg cctcgccctg tgtgtagacg gcgcccgcgg cgggactggt cagcacggtg
       61 accggcggct ggtgcgcgcc cgtgcaggcc gtgccgttga ccgcgaaggc ggccggggcc
      121 gtgttggtgc cgctgtagct gaactgcgcg ccggtcgaga cggcggcgcc cgtggcgatc
      181 gtgccgttgt acgaggcgtt ccgcacggtg atcgactggc cggactgcga ccaactgccg
      241 ttccagccgt tcacgagctt ctgattgccc gcgtagccgt acgtcagcgt ccagccgtcg
      301 atcgggtccg tgccgcggtt ggtgagggtg aggtcggcgg tgaaaccgga gccccagtca
      361 ttggtcctgt agtcgacgct gcactgaacc gtcgccgcct gtgcgggagt cgtccccgtg
      421 gcgagcatcg acaggggaag ggcgagcgcg gcgacgacgg cggtccataa ccgccgtacg
      481 gctctgcgcc tacgtccgga atgtccggga tgcatgtgct ggttcctcct tgtgctgacg
      541 aaacgtgggg agtagtcaag gcttgaacca gtgggagcgc tcccatagtg gggacagggg
      601 tgagagcggt caagatgctt gaagagtcga aaagattcga cgactccgtt gaggaaatgt
      661 cagccgactc ccctgtccat cttcgtcact tggcgctacc ttccttcgca ccagtgggag
      721 cgattccgtt cagtcgacgc gtccggcacg cgtccgagct gcaaggagtc gctcatgcga
      781 caccccccgc gttcactact tttagccgtc gccggtgcgg tcgccctcgt cgggaccgca
      841 ctggcgccgg tggtctcggc gtccggggcc acgcccgcct gcacggtcga gtactccgtc
      901 accggccagt gggacaccgg cttccagggt gccgtgaaga tcaccaacaa cacggccgcg
      961 ctgagtggtt ggagcctcac cttcgacttc gcgaacggcc agaaggtcac ccagggctgg
     1021 agcgccaagt ggtcccagtc cggcaccacc gtgaccaccg ccaacgagag ctggaacggc
     1081 tcgctcggca ccggcgcgag tgtcagcgcc gggttcctcg gctcctggtc gggcagcaac
     1141 gccgtaccga ccgcgttcaa gctcaacggg acgacgtgca acgcggatgc ggagccctcg
     1201 cccaccccta ccgagccgcc accgggcaac ggcaacgcac ccgccctgca cgtcttgggc
     1261 aacaagctcg tcgacgccga cggcaagacc cgccggctgc tcggtgtgaa ccgctccggc
     1321 ggtgagttca tgtgcgtcca gggctatggc atctgggacg gtcccgtgga cgacgcggcg
     1381 atcaaggcga tcgccgactg gaaggcaaac gccgtacgca tcccgctcaa cgaggagtgc
     1441 tggctgggcc tttccaacat caagcccgag tacgccggcg ccaactacat caacgccgtc
     1501 aaggacctgg tggcccgggt cgaggcgcac ggcatgacac cggtcctcga actccactgg
     1561 tcctacggcc agtacaccgg caactccgcg ggctgctccg acgtgcacgc cagctgccag
     1621 aagccgatgc ccgacatgca gtacagcccg tcgttctggt cctcggtggc cagcaccttc
     1681 aagagtgacc cggccgccgt gttcgacctg ttcaacgagc cgtacccgga ccgggcgacc
     1741 tccaccacca cccaggcctg gcagtgctgg aaggacggcg gcaactgccc cggcatctcc
     1801 tacgaggtcg ccggcatgca agacctcgtc gacgccgtac gcggcaccgg cgccaagaac
     1861 gtcatcatgg cgggcgggct cgcgtactcc aacgacctga gccagtggct gacgtaccgg
     1921 cccaccgacc cggccggcaa tctcgtcgcc gcctaccacg tctacaactt caacacctgc
     1981 gcgaacgaga gctgctggaa ctccaccctc gccccggtcg cggcccaagt cccgctggtc
     2041 gccggggagg tcggtgagaa cacctgctcg cacgcgttcg tcgaccgggt catgaagtgg
     2101 ttcgacgacc ggaacctgtc ctacctcggc tggacctgga acacctggga ctgctcctcc
     2161 ggcccttccc tgatcaccgg cttcgacgga acccccaccg cgtacggcat cggcctgcgc
     2221 gaccacctgc gcgccatcaa cccgtagccc ccaccgaaga aggagcccca ctcatgagtc
     2281 gtaccagaac agcggtactc gccgccctgg cgctcgtcgc cggggcctcg ggaacggccc
     2341 tcaccaccgc accggcgaac gccgccgcgt ccgccgtccc gtgcaccgtc gactacaagg
     2401 tgcagaacca gtgggacacc ggcttcaccg ccgccgtcac cgtcaccaac aacggcgccg
     2461 ccaagagcgg ttggtcggtg aagtgggcgt actccggcaa ccagaaggtc accaactact
     2521 ggaacacgaa gctcacccag agcggcagcg ccgtcaccgc cgacaatgag acctacaacg
     2581 gcacgctggc gaccggcggt tcggtcagct tcggcttcaa cgcctcctac agcggcggca
     2641 acgccatccc gaccgccttc acgctcgacg gcgtcacctg caacgtcgac gacgggggca
     2701 gcggcggagg cggagggggc ggcggcggtg gcggtaccgg cagccgggtc gacaacccgt
     2761 acgccggtgc caaggtgtac gtgaacccgg agtggtccgc gaaggccgcc gcggagcccg
     2821 gcggcagccg cgtctccaac cagcccaccg gcgtctggct cgaccgcatc gccgccatca
     2881 acggagtgaa cggcagcatg ggcctgcgcg cccacctcga cgcggccctc gcccagaagg
     2941 gcagcaacga agaggtcgtc caactggtcg tctacgacct gccgggacgc gactgcgcgg
     3001 ccctggcgtc caacggcgag ctgggcgcga ccgagatcga caagtacaag acgcagttca
     3061 tcgacccgat cgcggcgatc ctctccgaca gcaagtacgc ctcgctcagg atcgtcacca
     3121 ccatcgagat cgactcgctg cccaacctcg tcaccaacac cggcagccgc gccaccgcca
     3181 cgcccgcgtg cgacaccatg ctcgccaacg gcaactatgt gaagggcgtc ggctacgccc
     3241 tcgccaagct cggcgcgatc cccaacgtct acaactacct cgacgccggg caccacggct
     3301 ggctcggctg ggacgacaac ttcggccccg cggccaccct gttcaagcag gcggccacca
     3361 gcgagggcgc gaccgtcgac gacgtggccg ggttcatcac caacaccgcc aactacagcg
     3421 ccctgaagga gaacaacttc accgtcaacg acacggtgaa cggcacctcc gtccgccagt
     3481 cgaagtgggt cgactggaac cgctacgtcg acgagcagtc cttcgcgcag gccttccgca
     3541 accagttggt ctcggtcggc ttcaactcgg gcatcggcat gctgatcgac acctcccgca
     3601 acggctgggg cggcaccgcg cgcccggccg gccccggccc gcagaccagc gtggacacgt
     3661 acgtcgacgg cggccgctac gaccgccgta tccacgtcgg caactggtgc aaccagtccg
     3721 gagccgggct cggcgagcgc ccgcaggccg ccccggcgac cgggatcgac gcctatgtgt
     3781 ggatgaagcc gccgggtgag tccgacggct ccagcaccgc catcgccaac gatgagggca
     3841 agggcttcga ccggatgtgc gacccgacgt acacgggcaa cgcccgcaac ggcaacaaca
     3901 tgtcgggcgc cctgccgaac gcgccgctgt ccgggcactg gttctccgcc cagttccagc
     3961 agctgatgca gaacgcctac ccgccgctgc cgtgacgcgg tgacggtgat ccgccggggt
     4021 cagccctgcg gggacagacc ccggcggatc gcgagttcca cgggcgagtg gtcgccgtcc
     4081 gcccggtcca gctccagcgg cgactccagg tgcagcggcg gctgagccat gaagcggggc
     4141 cgggtcccgt ggtgcggctg agcggcgtgc accaggaagg gatggcagag gtagacatcg
     4201 ccgggactgc cggtggcgta cgcgagcggg cggtgtgcgg aggcggcggc cacctgcggt
     4261 ccgagctcca ggaacgaggc gccggccgcg ccgtacggct ccaggaccgg cggcacgtcg
     4321 aggtgcgagc cgaccctgat ccgggtcggg gcgtccgcct cggtcacctc gctgaacagg
     4381 aacagcatca gcagcgcacg ctccctggac agcaggttgg tgtgccactg gtcggcaccc
     4441 tccgggagat agctgccctc gatgtgccag cccgcgtcgt ccggctcctc cgcgtgcgga
     4501 aagcgcaacg ggaagctccc cagcgaatag cgcggggccc agcgccgctc accgaccagc
     4561 aggtcgaacg cctcatgcag tacggcggag ttggcggcgg ccgcgaacgg tccctgggcc
     4621 atcccgccca cccacaccac cgggtccttc caggtgccgg ggtcgtccgg gtcgtacccc
     4681 gtctcccgcc agagcagccg cgcgcagtgc tcggtgacgc gcttcgggac ggcgccctcg
     4741 atcttcacga acccgtcctc gatgaaccgc tgcaccatct cgtcgcccat cgggccatcc
     4801 tcggcgaccg gtgttgccgt acgcacccga atttttgccg ctccggcaac agagctggcc
     4861 ccggcccggt gcgtcggcgc aagctggccc cacccggacg agaggctgac caccatggcg
     4921 caccaccacc agcacggcca cggccatgac cacgcggaca ccgacatcga ctgggcggcc
     4981 atggcccctc acctggaggc gcaggcggag ctgctcgccc ccgtctacga gcgggccatg
     5041 gcctggctgg cgaaggaggt gaccgagccg gggctgatcg tggacgcggg cagcgggccc
     5101 ggtgtcgtgt cgtgtctgtt cgccgaggcg ttcccgggcg cccgggtgat ggccgtggac
     5161 gccaccgagc cactgctgga gcgggcccgc gaccgtgccg cccgccaggg cgtcggggac
     5221 cgcttcggca ccctggccgg tgaactcccc ggtgtgctgg aggagttgga ctacccggcc
     5281 gacctgctgt gggccagccg cagcctgcac cacctcggcg atcagcgggc cgggctcgcg
     5341 gccttcgcgg cccggctggc ccccggcggc accctggccc tgctggaggg tggtctgccg
     5401 tcccggttcc tgccccggga catcggcgtc gggcggccgg ggctgcaggc gcggctcgac
     5461 gtggtcgagg aggagtggtt cgcacggatg cgggccgacc tgcccggcgc cgtcgccgtg
     5521 accgaggact ggcccgctct gctggcggcc gcgggcctga agcacacccg cacccgcagc
     5581 ttcctgctcg acctgcccgc ccccgcctcg gaccgggccc gcgcctacat cgccgcgacc
     5641 ctctcccggg tccgcgaggc cgccgccgac gccctggaca ccgaggacca cgccacgctg
     5701 aaccgcctcc tcgacccgtc cgacccggcg agcgtgcacc gacggccgga cgtgttcgta
     5761 ctgtccgcgt acacggtgca cacggccgta cgtcccgtat agcccgtcgg gcggcggccc
     5821 agcaccgccc cggccgcgcg tacacactca cccgagcacc ccgcaccgtt caggggccgc
     5881 acttgtcgag gcaagcacct gccgccactg cgggtgtcac gagccccgac ggccgccgtc
     5941 ttgccgtagc cgactaccgc ggccgcctca ccctgtggga gacggcgcag ccgcgcctcg
     6001 ggcccgcgat cctcccggcc ggggacggtc cggtcctcgc ggtcggattc ggtccggacg
     6061 gcgccgagtt gcatctcgcc ccccatctgc cggaacgggt gggctcgttg gtgacggacc
     6121 gtgccgtcac cgaggtgcgc tcgcgcgcga acggccgtgc cacggaggcg gagtggcgtc
     6181 gccaactgcc ctcggtaccg taccgctgta cttgcgtcgc ttgacttcga gtgcgctcca
     6241 aatggtgaac tcccctggtt caccgaacca cagggggtaa ccatgaccga ctctccggtc
     6301 gcgctcatca ccggtggcga tgggggtccc cccgctcgag cgaagccgag agtgggggag
     6361 gcatcggtgc cgccgttgcc cggcagttgc tggacgccgg gtaccgggtc gccgtcaccg
     6421 ggcggggcga gccgcggctg cgcgcgttca gagaggggct cggcaagccg gacgggctgc
     6481 tgacgatcgt cgggaacgcg gccgagtacg gcgacgtaca ggcggccgtc gccggcacgc
     6541 tggaggagtt cgggcggctc gacacggtcg tcgccaacgc gggttccgcc acgcacgact
     6601 cggtcgcgga gggcgatccc gccgggtgga cggacatggt gctgaccaag gtgctgggcc
     6661 cggcccttct catccgcgcc tccgtcgacg ccctgaagga gacccggggc aggatcgtgc
     6721 tcgtcggcag tgtcgccggg ttcgtcaaca cgcccggcaa tctctacggc gccacgaagt
     6781 gggcggtcac cggcctcgcc gagaacaccc ggcgccaggt caccgagtgg ggcgtgggcg
     6841 tgaccctggt cgcccccggc cgggtggaga ccccgttctg gcacggtctg ggcagccttc
     6901 cgcccggcca cctcctcacc gccgaccaga tcgccgacac ggtcgtctgg gccgtccggc
     6961 agccggccgg tgtcgacgtc gacaccgtgg tcgtccggcc ggtcgggcag cccaactgac
     7021 gtacgcacag ggcccggtgc cgccccaggc gcggtaccgg gcccttctcc cctcccggct
     7081 cagttgttct ggaggaactg tttcgccagc tggtcgccga gagtcaccgc cgcgctgtgg
     7141 ctctcgatgg gggagacctt ggagttcttg aacaggatgt acgtcacgcc ggagtccacg
     7201 ccgccggtcg ccgggtcggg gtcgatgccg agcgccttgg cggtggcgta cgaggcctcg
     7261 ccgatgatct tcgtggggcc ggtgtcgccg acgaccgcgt actcgacctt gttgttgtag
     7321 atgacggcga ccactccgcc gcccttgatg ccggcgctgg agtagttcca gatgccgctg
     7381 gagctgggca cgacgacgta gggcagcgac tcggccttca ggggcttgcc gttggactgg
     7441 tggaaggccg tgtcgtcctg gtaccagggg tcgcggtcct cgttgcagtt ggtggtgcgc
     7501 tggccgtcgc agtcgatgtc catgtcggcc ttccagaaca ccgcgccgtt cttgccgcac
     7561 acggggacgg tggccgaggt ctcgtcgtcg gtcttgtact tgccgttgga tatctgcgaa
     7621 caggacttca ccttggcgag cagatcggcc gcgctgaccg agccctcctg ggtggacctc
     7681 ggggtggtgg agccggaggc gcttgcgggg agtacgccgg cggcgagcag tgcggccccg
     7741 gaggccgcgg cgagggtcag tgttcgaacg cgcactgtgg gggacccttc tgttaggaaa
     7801 ctttccttac cgggtccgta caacttggcg ctctttacgt ggccccgtca agccctgcgg
     7861 cgcgaacggg tgttccgtgt gccgtttgcg gtgatctgcc cgccagagaa cactggcgat
     7921 atcggccact ccggaatttc gcgcccgata tgcacacggt ttctgggagg cgaggcgcca
     7981 tgttcgtacg gaccgtctat gtgaccggcg atcccacgaa gatcgatacg gccatcagag
     8041 ccctgaacac cgagggccgg gacctgctcg aagaacgtcc gggctaccgc ggcgcaggcg
     8101 tcttcgtgga ccgggagctg ggcaagctct tctcgacgag ctggtggtcc tccgaggagg
     8161 ccaggcacaa cagcgacgag gtgatgcgcg agcggcgcgg cgccctcctg gaaccgttcg
     8221 cgggaaccgt ggcggtcgac aactacgagg tggcggtcta ccacgcgcag cagatgccga
     8281 ggacggccgg cggactgcgc atcaccaggc tggagttcga gcccgcggac acggacctgg
     8341 tcgccgatac gttccgggcc agtgtgctgc cccggctgga gaccctgcac gggctggcca
     8401 gggcctccct gttcgtggac cgggaccgcg gaagcggcat ggtccacatc ctgttcgtcg
     8461 accacgggtc catggccgct tcccgctcgg cccaggcgat ggcccggcac gaggggaccg
     8521 ccaaggcgca tgtcaccgtg accggtcttg aggagttcga ggtcgtccac gcggacgtgc
     8581 accccgactg aggtcctgtg ccgggccgtt gaccggcgcc tcgccccgtc acacgtgtgc
     8641 cccgccgggc gggaggtcgt ccggcggggc acacgcacgt acggaggcgg gcctcagccc
     8701 atctcgaacg tggccgggtc cggacccagt cgccggtcct cgttcagcgc gctgatcgcc
     8761 gcgaggtcct cggcgtccag gctgaagtcg aagacgtcga tgttctcctt gatccgggac
     8821 ggcgtcacgg acttggggat cactatgttg cccagctgga ggtgccagcg cagcacgatc
     8881 tgggccgggg tgcggttgtg cttctgggcg atggcgacga tcgccggcac ctccagcagc
     8941 cccttgccct ggccgagcgg ggaccacgcc tcggtgtgga tgccctgctc cgcgtggaac
     9001 gcgcgggccg cgtgctgctg cagatgcggg tggagttcga tctggttgac cgcagggatg
     9061 accgacgtct cggccagcag gcgttccagg tgctccggaa ggaagttgga caggccgatg
     9121 gcacggaccc ggccctcggc gaggagcttc tcgaaggcct tgtaggtctc gatgtacgtg
     9181 ccccgggacg gcagcggcca gtggatcagg tacaggtcga ggtagtccag gcccagcttg
     9241 tccagggaca cgtcgaaggc gcgcagcgtg gcgtcgtacc cctggtcgct gttccagagc
     9301 ttggtggtga cgaagacgtc ctcgcggggc aggccggacg cggcgatcgc cttgccggtg
     9361 ccctcttcgt tgccgtagat cgccgcggtg tcgatgctgc ggtacccggc ctcgagtgcc
     9421 gtggcgacgg cacgctcggc ctcgtcgtcc ggcacctgcc agacgccgaa gcccagctgg
     9481 ggcatctcga cgccgttgtt gaggatgatc ggggggacct tgctgctcac gagctcttga
     9541 tccttcgctt gtcgacaggt cgtaccacta tcgtcaacga tcacgagcca ggatgcattc
     9601 ctgaccgcgg aatccatcgg aactgaccgg tgagtcagtt ccggagacgg agaatggccg
     9661 gaaatgcatc cgacgttatc ggtccggacc attgaccgcg gcccgtcatc ccgggactct
     9721 gaatcccgcc accgaacgcg tcgatgaact gggtgcacac atgtgaacaa ccgacgccat
     9781 tggtgcctgt ctgcgcaaat gagacccccc actctcagga aagcaggtgc gtacacatga
     9841 atgagaccct gcccgaggct cgccaggcgg aacaaaccgt tcaggagaca tcggatgaaa
     9901 acggctggca gagccccggc tacaccgttg tggaaaccgc actcgaagtg accgcctacg
     9961 ccctcggcga ccgctgaccc gagacacggc gaaccgcacc atgaccgcga cacccgtacg
    10021 cgccgacggc accgcgcccc cgtggccggc cgccgagttc acccggcggc tgtgcgccgt
    10081 caccgccgag cgctaccacg accgccaccc cttcaacctg cggatgcacc gcggtgaact
    10141 cacccccggt gaactgcgcc gctggatcgc caaccgcttc cactaccaac ggcacatccc
    10201 cgtcaaggac gccctcgtcc tggccaaact cgaccgtccc gcgctgcgcc gcgcctggct
    10261 gcgccgcatc cgtgaccacg acggcacggc cgagggcgag ggcggcatcg aacgctggct
    10321 gcggctcggc gaggcggccg gcctcacccg ggacgaactg tgggacacct cccaggtgct
    10381 gcccggggtg cgccacgcgg tcgagcggta cgtctccttc tgccgccggc gtcccgcgct
    10441 ggaggccgtc gcagcctctc tgacggagct gtccgcaccc gacctgatgc gcatccgcat
    10501 cgccgccttc gaacgccact acccgtggat cgacccgtcc ggcctcgcct acttccgcac
    10561 ccgtgtcggc cagggcgccc gcgacggtga ggaggccctc gccctcgtcc acgcctgggc
    10621 ccgcacccgt gagcagcagg aacgggccgt ggccgcgctg gtcttcaagt gcgacgtgct
    10681 gtgggagctg ctggactccg tcgaccgggg cgacagcgtt gccgggggcg ggccatgacc
    10741 tggcgtcccg tcctgtcccg gggcgtggtg ctgcgccacg accgggtgcg ctgcaccgat
    10801 ctcctgttgc tgcccgaacg cgtggtcgtg ctgcacggcc gggcgggcgg tgtgctgcgg
    10861 ctgtgcgacg gcagccggga ggtgcgcgag atcgtcgccg aactgcgcgc gggatacccg
    10921 ggggcgccgg tcgccgccga agtcccctac tttctcgccg cgttgcggaa ggagggctgg
    10981 ctgacatgac cccggatccc ccgtgggccc tgctcgcgga gctcacccat ggctgcccgc
    11041 tgcgctgcgg ctactgctcc aaccccgtcg aactggtcgg tcggtcagaa gagctgaccg
    11101 cgcagcagtg gatgggagtg ttccggcagg cggccgcgct gggcgtcgta cagacccatc
    11161 tgtcgggcgg tgaaccgctg ttgaggcgcg acctgccgga catcgtcgcc gccgccgaca
    11221 ccgccggtct gtacacgcag ctcgtcacca gcgggctcgg tctgggcgag cggcggctgg
    11281 cggccctcgt ggacgccgga ctgcgcagcg tccagctctc cgtccagcac gcggacccgg
    11341 cggcctccga acgcatcgcg ggcgcccgct cgttcgtggc caaggagcgg gccgcgcggc
    11401 tcatccgcgc ggccggagtc cccttcgggg tcaacgtcgt cctgcaccac ggcaatctcg
    11461 acgccctcga cgacctgatc gctctcggcg tggcctgggg cgtggaccgg atcgagctcg
    11521 ccaacaccca gttccacggc tgggcgctgc gcaaccggac cgccctgctg cccacccccg
    11581 agcagacccg gcgggcccac gacacggtgg ccgactggcg tcaacggctc cgtgacggac
    11641 ccgagttggt gtgggtcgca cccgacctcg tggacgccac ggccaagccc tgcatgggag
    11701 gctggggcag ggtctcgctc accgtcgccc ccgacggcac gaccctgccc tgtcccgccg
    11761 cggccgccct cccgggcctc gatccgccga atgtgaagga ccgcccgctc gactggatct
    11821 ggcggcggtc gacggccttc aacgcgttcc gtggcgagtc ctggatgcgg gagccctgcc
    11881 ggacctgcgc tttgcgcacc accgaccacg gcggctgccg ctgtcaggcg tacgccctca
    11941 ccggcgacgc cgcccgcacc gaccccgcct gccggcacgc ccccgaccac cacctcgtac
    12001 gcgacctcgt gcgtctcgcc gacgcagacc gagacctcgc gtacgcctac cgcgaaggag
    12061 gaccatgaga cgccgacgtc tgcgtgcggc gctgacggca ctcgcgctga ccacgggtgg
    12121 cctggccgcg ctgcccgccg ccgtcccccg gccgtcgccg cccccgcccc gcgccggccg
    12181 gccgccgcca ccgactggtc cacggccgtg gtcgactcca ccatggaccg ctacacaccg
    12241 gccaccatcg gcggctggtc gtacccggtg ggcctctacc tctacggcca gtacctcacc
    12301 taccggcgca cccacgacgc gcgctacctc acctacatca agagctatgt cgaccgcttc
    12361 gtgaagagcg acggctccat cggccagtca ttcaacaacc tggacagcat gcaggccggc
    12421 cggctgctgg tgatcctgca ccacgagacg ggccaggacc gctaccgcaa ggcggccaag
    12481 aagatccgcg accgcctggc cacctacccg cgcaccgccg acggcggttt ctggcacgcc
    12541 gacaacagca gccgagccca tcaactctgg gccgacggtg tctacatggt gaacccgttc
    12601 ctcgtcgagt acggcaggga gttcggcgac cgtgcgtaca cgaacgacga ggcggccgag
    12661 cagctcgccg tctacggcgg tcatctccag gtggcgaacg ggctgttgaa gcacgcctac
    12721 gacgagtcga ggaccgcgag ctgggccgat ccgcacaccg ggctcgcacc cgagcactgg
    12781 tgccgggcga tcggctggta ctcgatggcg atcgtcgatg tgctcgacgc gatcccgggc
    12841 ggccatccgc gacggcccca gctcctcgac atcttccggc ggctcgcggc cggtctcgag
    12901 aagtaccagg acccggcgac cggacgctgg ttccaggtcg tcgacaaggg tggccgcgcc
    12961 gacaactgga ccgagacgtc ctgctccagc atgttcacct acgcgctgtt ccggggcgcc
    13021 caacagggct atctggaccg gcacttcacg gccgtggccc ggcgtggcta cgagggcgtg
    13081 ctggcgaagg tctcggtcgg cacggacggc cgaaccagcc tggccgacat ctccatcggc
    13141 acgaacgtcg gcgactacgc gtactacatc gcgcgcaccc gggccacgaa tgacttccac
    13201 ggcctagggg cctttctgat catgaacgag cagctgcgag gagattagtg tcatgagcac
    13261 gtctagatgg ggcacggcca gaagggcggt gctcggtgcc gcactcggcg gcgccgcgac
    13321 agccgcggtc ggcctgcccg cctcacgcgc ctcggccgcg tcctggcagc tgaagtggtc
    13381 gccctcggcg agccgcgacg gcctcggcgc cttcgagacc gtcgaggacg accgcgcgga
    13441 ttcccacccc gccgggcacc cgcacatcca ccccaccggc gacaactggc gcttcaccat
    13501 gcacaaggtc gaccgcgaca cctcgaccga ccgccagcgt caggaggtca ccggcctgcg
    13561 cacaagcggc agtggctatc tgaagtggac ccagggccag acctggcgga tcacctactc
    13621 gatgtacatc ccgagctcgc tgaaggcgac caccaccttc acccacatca tgcagatgaa
    13681 gcagcccggc aacggcacct cgccgatcgt cgtacagtcc ctgcgccggg atgggggcac
    13741 ctccctgctc gagcgaagcc gagagcttgg gggaggggtg cagaccatcg aactcaggct
    13801 ggccatcgac gacatcctgg tcggccgcac cgatctcgcg ccgctgcacg acaaatggac
    13861 cgacgtcgac ttccagatca aggtcggcaa cggctcggcc ggctcggtcc gctggatcct
    13921 caagagcggc tccacgaccg tcgtcgacaa ggccaggacc ggcgtcgaca ccttcctcgc
    13981 cgaccgcgtc cgcccgaagt ggggcatcta ccgctccctc ggcgacacct ccggctccct
    14041 gcaggacacc tacctgctcc tcaccgatct ccgcggctac caactcctct gaggagccgt
    14101 catatgcgtt ccaccacccc ccaccgaaga ggtgcggcgg cgatcgtact gtccgtcctc
    14161 gccgtcgtcc tcggcctcgc ccaccccgcg gccctcgccg ccccacaaca gcctcaccgc
    14221 gcggccgccg tctacgacgt gcgcgactac ggcgccaagg gcgacggatc cgccaacgac
    14281 acccccgccg tcaacaaggc catcaccgcg gccaattcgg ccggcggcgg caccgtccgc
    14341 ttcccggccg gcacctacag gtccaagaac accatccaca tgaagagcga cgtgacgctc
    14401 caggtcgaca cgggcgccac gatccagggc tcctccgcgg acacctacga cccgcccgag
    14461 tccaacccgt acgacaagta ccaggactac gggcacagcc acttccacaa cgcgatgatc
    14521 tacggcgacc ggctcacgga catcggcttc gtcggcggcg gggtcatcga cggggccggc
    14581 aacctgatca ccggcaaccc caagtcagga gaggccgaca agatcatctc gctgacgagg
    14641 tgcgacgggc tgcgcctcgg cgacggtctc accctgcgcc gcggcggtca cttcgcggct
    14701 ctcgtcaacg gctgcaagca cgtcacctcg gaccgtctca ccatcgacac cgcgagcgac
    14761 cgcgacggct ggaacatcat ctccaccacc gatgtcacgg tcacccgtgc cgacatcaag
    14821 gccaatgacg acgccctggt cttcaagagc gactacgccc tcggcgccaa gctgcccaac
    14881 ggccatgtcc gggtgcgcga ttcctccttg tcggcccggt gctgcaacgc cctgatgttc
    14941 ggctccgaga cctgcggcga cttcaccgac taccagttcg agaagatccg tatcgagggc
    15001 gccgacaagt ccggcctcgg catggtgtcc atggacggcg cgaagatctc cgacgtccac
    15061 taccgcgaca tcaccatgac cgacgtccac tcgccgatca tggagaagat cggcacgcgc
    15121 aaacggtgcg gcgacagccc cggcgtcggc tcgatcagca acgtgacgta cgacaacatc
    15181 acggccaccg gcagcggccc ctccttcagc ccgaccctgt ggggcgagaa cggccaccgg
    15241 atcaacggca tcacgttccg ccatgtcgac atcaccgtgc ccggcggcaa cggcaccatg
    15301 tccacgggcg tgccgggcaa cgacccgaag gactacaacc ccaaggccat cggcacccgt
    15361 ccggcctacg gctggtacct gcacaacgcg gacgacgtca ccttcaccga cagctccgtg
    15421 aagttcgccg cgaacgacgg ccgtcccgcg gtcatcgcca acgctgcgag caatatccgc
    15481 ttcactcgct tcaccgccca gcgcggcagc aactccccgc acgacaccgg cttccagagc
    15541 gtcagcggct actgcctgac ggacagtcac aacacctccg gcggcgcgct gcggacctcg
    15601 tccaccgggt ccaccgagaa ctgcggtgcg caggccaggc ccctggacct cgacaacccc
    15661 cgccaggact tcctgcgcaa ctccgtcggc ggcctcttcc tgcactgggg cctgcgcacc
    15721 gcccccgccc acaccaattg cggcgcctgg gagaacgacg tcaccagcgg cggctggaca
    15781 ccggactact gggtgaacga ggcccgcaag ctgcatacgc agtacctcgt cctggccacg
    15841 ttccacagcc ggctgggcta cgcccgcccc tggccgtccc ggatccccgg ctcctgctcc
    15901 accaagcggg acttcctcgg cgagctgatc accgccgcca aggccaaggg catgaaggtc
    15961 atcctctaca tgaccgacga cccccagtgg cacgacgagg gcggtcacga gtggctggac
    16021 tcggccggct actccgccta caagggcaag aacgtcgacc tgaccacccg ggacggcttc
    16081 gggcagttca gctacgacaa cttcttcgag gtcatggacc gctatcccga cctcggcggc
    16141 ttctggatcg acaacgacaa cgcgtactgg gagagccaca acctctacgc gcagatctat
    16201 cggaagcgcc cgaactacac gctcagcaac aacaacgaag acacgccgat catggacatg
    16261 atcagcaatg agcagaagac cgggatgacc cccgcctacg actacccgca ggccgtctac
    16321 acggctcaac cgcgcctgac cgaggccgac ttcaaactgc cctcggccgg cgcctggtgg
    16381 tacgacggct ccgacccctc ggtcgaccgc aagctcaccc tcggccggct cgtcaccaac
    16441 gccggttcct cggtgaaggc cctgatggcc gagaccgccc aggtcgacgg caggttcccg
    16501 gccaaccagg ccgccttcaa caccttcgcg aacacctacc tcgaccccat ctgggagtcc
    16561 ctgcacggca ccgagggcgg cggctatctg tacggcggcc tcaaacccgg cttctggaac
    16621 gacggcgcgc acggcgtgac cacgatcagc aggacggacc agaaccggca gtacatccac
    16681 gtcctgaccc cgcccagcac cagcaccctg cgcatccgcg acaacggcta ccgcatcacc
    16741 tcggtcaccg acctccgtac cggagcggcc gtttcgtggt cgcagtccgg cggtgtgctc
    16801 aggctcaccg gcctcggcac ctgggacccg tacgacaccg tcttcaaggt caccacggcg
    16861 ggccgccagg gcatcctcaa gggcgtcaag gtctccgcga gcgcctcggc gagcggccac
    16921 accggctccg ccgccggtga cggcgaccac ctcacctact gggacaacga caagaccctg
    16981 cccgtcgacc tcaccttcga cctcggcacg gcgaagaagg tgcggtacat cggcctcaac
    17041 cagcgggagg actcggtcgc ctacgcccgc tccgccaccg agcagtccgc ccgcatcaag
    17101 gactacaagg tcttcctgag caacgacggc tccacctggg ggagcgcggt gaagaccggg
    17161 cagctcccga gccggcgcgg catccagggc atcgacctca ccgccgccaa cgcccgttac
    17221 gtgcgcctgg aggtggactc cacctgggcc gcgtcgaccg acaccacccg ctacaagcgg
    17281 ctgcggatcg acgaggcgtg gatcggcacc gcgtacgcga caccggccga cctcaccacc
    17341 aagtcggaca acggccagtc cctccgcccg gccatgggct ggagcagctg gagcttcgtg
    17401 cgccgttggc ccaccgaggc gaagatcaag gcgcaggccg acgcgctggt ggcgagcggg
    17461 ctgaaggatc acgggttcgt ccaggtcaac ctcgacgact tctggcagac gtgcgactcc
    17521 aacgggttcg tcgtcgactc ctacggccgc tggaccgtga acgccgccaa gttcccgtcc
    17581 gggatcaagg cgctcgcgga ctacgtccac tccaaggggc tgaagttcgg cttctacgtc
    17641 accccgggca tcgccaagaa cgcggtcacc gcgaatacga cgatcgaagg gactccgtac
    17701 cacgcgaagg acatcgcgga cacctcgaag acggagaaga actacaactg caagaacatg
    17761 tactacatcg actactccaa gccgggcgca caggacttca tcaactcctg ggcacggcag
    17821 ttcgcctcct ggggagtcga ccatctgaag atcgacggcg tgggcagcca ggacatcccg
    17881 gacgtccagg cctgggacaa ggccctgcgg gccaccgggc ggcccatcac cttcgccctc
    17941 tccaacaacc tgccgatcgc gaacgccgtc acctggcgga agcttgccaa cagctggcgc
    18001 acccagggcg acgtggagtg ctactgcggg cccggcgcga acggcagcgg ctacccgctc
    18061 accgactggt cgcatgtctc cgcccgcttc acctcggccg ccgactggca gccgtacgcc
    18121 ggtcccggcg gctggaacga tctcgactcg ctggagatcg gcaacggcga ccaggtgggg
    18181 ctcaccgccg accagcggcg ctcgcacttc acgctgtggg cgatggcagg cgcgcccctg
    18241 ctgctcggca ccgacctcac ccacctcgac tccgtcgaca aggcgatgct caccaacgac
    18301 cggctcatcg gcgtcgacca ggacggcgtc gccgcgaaac gccttgtgaa cagtggtgtc
    18361 aagcaggttt ggagcaaacg cgaaaacagc ggtgactacg tggtggcgct gttcaacacc
    18421 ggaacctccg gccgcgccac ggtcagtgtg aactggtccc acgtcggctt caccggttcc
    18481 ggcgatgtca ccgacctctg gtccggctcc cacaagggcg tgatcgccga ctcctacagc
    18541 gcgaccctgc gcccggggga gacccggctg atccgcgtcg aacccgccgc ctccacgcgg
    18601 tcggcggcgg cctcgccggg cttcgccgtc gccccctacg agtacctcgg ctggggcaac
    18661 ccgcccagcc ccacctcggt catgtcggcg accggcgtca aatggttcac gctggcgttc
    18721 gtcctctccg acggcacctg caaccccaag tgggacggct cgcgcccgct gaccggcggc
    18781 aacgaccagt cgaagatcaa cgcgatcaga gcggcgggcg gtgatgtgat cgtgtccgcc
    18841 ggaggctgga gcggcgccaa gctcggcgag aagtgcgccg gcgcctccgc gctcgccggc
    18901 gcgtaccaga aggtcatcaa cgcctacagg ctgaaggccc tcgacatcga catcgagaac
    18961 accgagtggg cgagcgccac cgtgcggcaa cgcgtcgtcg acgcgctgaa gaaggtcaag
    19021 gccgacaacc ccggcctgaa gaccgtcatc accttcggca cgacgaccag tggccccgac
    19081 tccaccggtg tcgacatgat caagcgggcg gccgcctccg ggctcgtgaa cgacgtctgg
    19141 tgcatcatgc cgttcgactt cggcggcggc accaccgaca tgggcaccct caccacccgg
    19201 gccatggaag gcctcaaggc ccgggtcaag tcggcgtacg gctacggcga cgccaccgcc
    19261 tacgcccaca tagggctctc gtccatgaac ggcaagaccg acgactccgg tgagcgtgtc
    19321 cgcgtcgccg acttcaagac gatgctcgcc tacgcccagc agcaccacat cggacgcctc
    19381 acctactggt ccgtcaaccg tgaccgcgcc tgcggctccg gcaccgacgg cgactcctgc
    19441 agcggcgtgt cgcagcagcc gtacgacttc ctgaaggtct tcgcccagta cacgggctga
    19501 ggggaacgcc catgaatctc aagagagttc tgccgtacgg cctgaccgtg gccctcgcgc
    19561 tgccgctggc cgggctgagc cagggcaccg cgctcgcggc caccgactac caggccgagg
    19621 atgccctgat ctcgcagggc accgtggcca ccaaccacac cggctacacg ggcaccggct
    19681 tcgtcgacta caccaacgtc aaaagctcgt acgtggagtt cacggtgaac gcggccgccg
    19741 cgggcacctc gtcgctcacc ctgcgcttcg ccaacggaac ctccaccgac cggcccatgg
    19801 acatctccgt gggcggcacg gtcgtcgcgt ccggtgtctc cttcccggcc accgccgact
    19861 ggaacacctg gacgaccagg agtgtcaacg tccccctcgc ggcggggacc aacaagatcc
    19921 gcgcgaccgc caccaccgcc aacggcggcc ccaacctcga ccgcgtcagc ctcgccgccg
    19981 cggccgacag ccaggcccca acccgccccg gccggccgag ctgctccgac atcggcgaga
    20041 acggcctcac cctcggctgg ggcgcgtcca ccgacaacgt gggcgtggcg gcgtacgaca
    20101 tctacgaaca cggcaacaag atcagtgagg cgcccggcag tgcgaccagc aaggcgctga
    20161 ccgggctcac cccgaacacc acctacaacc tcaccgtcat cgcccgcgac gcggcgggca
    20221 acacctcgcc ggccagtccc gtcgtcgact gcacgacgaa gcccagctcc gacaccacac
    20281 cgccgaccgc gcccggcacc ctgtccacgg ccgacgtcac ggccaactcg gtcggcctca
    20341 gctggggcgc gtcgagcgac gaccgcgggg tcaccgcata cgacatccgc agcgggtcca
    20401 ccgtctacaa gacggtcacc tccggcacca cgaccacgct caccggcctc gcctgcgaca
    20461 gcccctactc cctgaacgtc gtcgcacgtg atgcggcggg caatgtctcc ccgcccggca
    20521 acacggtcac cttcaccacc aaggcctgcg ccaccgacgg cggtgtgccg tcgtccatcg
    20581 gcacgctctc caccggctgg accatcccct ggggcaccta ctggctgccc gacggcaagt
    20641 ccgccctggt caccgagcgg gacgacttcc gtgtccggag gctgaccaag gacggcacga
    20701 agaccgaggt cggcacggtt cccaacgtcg tcaccaccaa cggtgagggc ggtctgctcg
    20761 gggtcgccgt cgacccccgg tgggagagca accactacgt ctacttcatg cacacggcgt
    20821 ccgagggcaa ccgggtcgtc cgcatgacgt acaacggcag ctcgttgagc aactacacgg
    20881 tcctgctgca gggcatcaag aagaaccgct accacaacgg cggccgcctc gccttcggcc
    20941 ccgacggcta tctgtacgtc tccaccggcg aggcccagac ccccgacctg gcccaggaca
    21001 agaactccct gaacggcaag atcctgcgca tgacgacgga cggcaagccg gcccccggca
    21061 acccgttcgg caactacgtc tacagttacg gtcaccgcaa tccgcagggc ctcgccttcg
    21121 accgcaacgg gcggctgtgg gaggccgagt tcggcaacag ctccaaggac gagctgaacc
    21181 tgatcaagcc gggcgccaac tacggctggc cgacctgcga gggcagctgc agcgtctcgg
    21241 gcatgaccaa ccccaaggcc acctggaacg tctccgaggc ctcgccgagc ggtatcgcca
    21301 tcgtccgcaa cgtcgtctac atggcgtccc tgcgcggcga acggctgtgg cgcatcccga
    21361 tcgacggcga caacgagagc gtcggcacgc cgaccgcgta ctacgtcggc acctacggcc
    21421 ggctgcgcac ggtcaccaag gtcccgggct ccgaccagtt gtggctgtcg accaccaact
    21481 gcgacaacaa cggaggtgcg gcggacggat ccgacaagat cttccgcgtg accatcggct
    21541 gacggtgcgt caggcccggt agagggcttc cacctcgttg gcgtaggcgt tctcgatcgc
    21601 tttgcgcttc agcttcaacg acggggtgag caggccgtgt tcctcggtga acggctgggc
    21661 caggatacgg aaggtacgga tcgactcggc ctgcgagacg agggtgttgg cggcgaccac
    21721 cgcgcgccgc acctccgcct ccaggtcggc gtcgcgcacc agctcggccg cggtcagctg
    21781 cggcttgccg cgcatctgca gccagtgctc gacggcctcg gtgtccaggg tgaccagggc
    21841 ggcgatgtac ggacggtcgt tgccgaccac gatgcactgg ctgaccagcg gatggtcgcg
    21901 gacccgctcc tccagcacac cgggcgacac gctcttgccg ccggaggtca ccaggatctc
    21961 cttcttgcgg ccggtgatgg tgagatagcc gtcctcgtcc agggagccca ggtcaccggt
    22021 ggccagccag ccgtcgtgca aagtcgcgtc ggtggccttc tggttgtt
//
