LOCUS       NZ_CP106798            11350 bp    DNA     linear   CON 01-NOV-2023
DEFINITION  Streptomyces sp. HUAS 15-9 chromosome, complete genome.
ACCESSION   NZ_CP106798
VERSION     NZ_CP106798.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. HUAS 15-9
  ORGANISM  Streptomyces sp. HUAS 15-9
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9258818)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 169.8x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/01/2023 03:42:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,774
            CDSs (total)                      :: 8,679
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 95
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 504
            CDSs (without protein)            :: 504
            Pseudo Genes (ambiguous residues) :: 0 of 504
            Pseudo Genes (frameshifted)       :: 260 of 504
            Pseudo Genes (incomplete)         :: 328 of 504
            Pseudo Genes (internal stop)      :: 29 of 504
            Pseudo Genes (multiple problems)  :: 107 of 504
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:51:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6878771
            Orig. end                         :: 6890121
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106798.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11350
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="18"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11350
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11350
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6350](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6350)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            403..1134
                     /gene="hemQ"
                     /locus_tag="N8I87_RS31390"
                     /old_locus_tag="N8I87_31390"
     CDS             403..1134
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564417.1"
                     /locus_tag="N8I87_RS31390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31390"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_263213761.1"
                     /transl_table=11
                     /translation="MSDDAPTPETGRIPNKGKLAKDLNEVIRYTLWSVFKLKDVLPEDR
                     AGYADEVQELFDQLAAKDVTIRGTYDLSGLRADADLMIWWHAESSDQLQEAYNLFRRTK
                     LGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRNYVSVYPFVRSYDWYLLADEDRRR
                     MLADHGKMARGFPDVRANTVASFALGDYEWLLAFEADDLHRIVDLMRHLRGAEARMHVR
                     EEIPFYTGRRKEITELIAGLA"
     gene            complement(1407..3046)
                     /locus_tag="N8I87_RS31395"
                     /old_locus_tag="N8I87_31395"
                     /pseudo=""
     CDS             complement(1407..3046)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675655.1"
                     /locus_tag="N8I87_RS31395"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31395"
                     /product="alpha/beta hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRAAALYSAAGSLLLTALVAAPAARARPVLRVCRAR"
     gene            complement(3183..3968)
                     /locus_tag="N8I87_RS31400"
                     /old_locus_tag="N8I87_31400"
     CDS             complement(3183..3968)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675656.1"
                     /locus_tag="N8I87_RS31400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31400"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_263213762.1"
                     /transl_table=11
                     /translation="MFWVLLLLLAWAVAGTACTRLCLAAVRLAAVDAEGATADRGHDLT
                     LYEAAFLSGGPARVADLTMVSMARQRRLLLAHTGWATVVDPRGRDEMERSVIGAIGPEG
                     QSRIEPVRSAAAGADAVRSIADGLVRAGLAVPDGARTTVASGVRQVRLAAVAVAALGAT
                     ALLMPAQTDMPRDLVAAWFALPFALTLSCLAIARVEVHPYSRWASPAGQRLLGALTRRA
                     TGSGDDRTYLTSVAVRGIRAIGEPELRAAFAHRDQPWRE"
     misc_feature    3971..3980
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     gene            complement(4065..4853)
                     /locus_tag="N8I87_RS31405"
                     /old_locus_tag="N8I87_31405"
     CDS             complement(4065..4853)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997027.1"
                     /locus_tag="N8I87_RS31405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31405"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_263213763.1"
                     /transl_table=11
                     /translation="MRPRPRPPIKGRGIFSGLGLIITGLAATLAALLFPVWSYADRTGI
                     AGTGGTGADVLNAQTVTTQYGPLSQADRDFVTKVRLAGLWELPAGQLAETKGTTEAVRA
                     AGRHLVAGHTSLDAHALIVATRLGLPLPNEPNEQQKQWLTTLSTAQGQDFDREFANILR
                     LAHGRVFSVVAQVRAGTQNSLVRDLADDADTTVLDHIRMLEATGYVDFAALARDLATAA
                     SPVPSPPVVQPGSATPIGSSPSPTYPLPPAASSPPPGDGS"
     misc_feature    4906..4922
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.2"
                     /tool="antismash"
     gene            complement(5001..6350)
                     /locus_tag="N8I87_RS31410"
                     /old_locus_tag="N8I87_31410"
     CDS             complement(5001..6350)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122140.1"
                     /locus_tag="N8I87_RS31410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31410"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_263213765.1"
                     /sec_met_domain="DUF692 (E-value: 8.6e-97, bitscore: 322.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRLGTGIGWRPEIADAVERMPGIDWVEAVAENVCPGHLPESLLR
                     LRERGVTVVPHGVSLGLGGADRPDEGRLTALAERAAALGAPLVTEHIAFVRAGGPLTAS
                     PRLEAGHLLPLPRTRDALDVLCENVRIAQEALPVPLAVENIAALISWPGEEMTEGQFLY
                     ELAERTGVRLLIDVANLHTNHVNRGEDPAKALAELPLEAVAYVHVAGGFERDGVWHDSH
                     AHPVPRPVLDILTDLASRVAPPGVLLERDENFPEPGELERELESIRGAVEEGRAMCPVS
                     GAVQEGRAIRSVSGAASRVRAVTPPVVVADDDTRERLALAQTAVLSSLVAGTPVPEGFD
                     RVRMGVQARALAAKRASVVAKIAPELPVILGTEYRPAFLDYAHGHPMAGGYRQDALDFA
                     GQLLAGRIEDAGVRRELREWWLERSGPVPRSRRPVVRAARAARRVLLRRR"
     gene            complement(6520..7269)
                     /locus_tag="N8I87_RS31415"
                     /old_locus_tag="N8I87_31415"
     CDS             complement(6520..7269)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657150.1"
                     /locus_tag="N8I87_RS31415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31415"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_263213766.1"
                     /transl_table=11
                     /translation="MSHVSTSPGDSPFRSERSARDEAPQFVLPLVVRIERGAPPARTDA
                     LETAARSVLTLLADERALGDGEWAEAVRDWQDARIRKVVRRARGAEWRRAEALPGITVT
                     GESAQIRVFPPVPLDGWPKDLAKLQVSGTDLDDPEPPAGPDRARPVLWMNPELDMSAGK
                     AMAQVGHGAQLAWWELSDEDRAAWRDTGFPLSVRTADPAEWPRLTDSGLPLVRDAGFTE
                     IAPGSCTVVADHPALRRDPVDSRGVPG"
     gene            7305..8186
                     /locus_tag="N8I87_RS31420"
                     /old_locus_tag="N8I87_31420"
     CDS             7305..8186
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997024.1"
                     /locus_tag="N8I87_RS31420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31420"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_263213767.1"
                     /transl_table=11
                     /translation="MRRDLRLARVGRRYGIRGPWVLRGIDLTVTPGSLIRVEGANGSGK
                     STLLRILAGLDAPTEGRITGRPRTAYVPERFPSALPFTAAGYLTHLGTVHGLSRRTAAG
                     AAVAWLDRFGAAAHADTPMAQLSKGSSQKVAVAQALLAEPELLVLDEAWTGLDAAARAE
                     LERAVAERTAAGCAVVFVDHDPRRLAGAPDETYVVTDGTLDRRTGNESSPAGRHAVVIA
                     QGPSGGQLPPDAARTVTSAEETAPRTHRLTVPESHSDVLLRALLTARPPWHVVSVSPGT
                     PPETPPDPESRS"
     misc_feature    7368..7370
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8183..8854
                     /locus_tag="N8I87_RS31425"
                     /old_locus_tag="N8I87_31425"
     CDS             8183..8854
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997023.1"
                     /locus_tag="N8I87_RS31425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31425"
                     /product="ABC transporter"
                     /protein_id="WP_263213768.1"
                     /transl_table=11
                     /translation="MTALLRYQAALLVRSQRWLPPVVLYAAFLAVGVQSGQPVLDSLGY
                     TAAALLPVAAWLVRICVTNEPPAARACVAAAAGPARAHLACLLAALLASAALGTVATLA
                     VTLISDPAANGHRAHVPRFEAGAAGLLAALSCALLGTAVGALTNWPLLRSPGRAVPAML
                     LAALLSVVVAGSPAQAAVNGLVTGSQSGRVPVPLLPLAAAALLTAAAFAVACALTRRRS
                     P"
     gene            complement(8846..9068)
                     /locus_tag="N8I87_RS31430"
                     /old_locus_tag="N8I87_31430"
                     /pseudo=""
     CDS             complement(8846..9068)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675663.1"
                     /locus_tag="N8I87_RS31430"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31430"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDEDYCTIIDTTESQPADEPPYAECVLCRKPTEYPASYRGTTLC
                     PVCMGGPPCSSEVENSGEAGGAAHGLLRV"
     gene            complement(9087..9935)
                     /locus_tag="N8I87_RS31435"
                     /old_locus_tag="N8I87_31435"
     CDS             complement(9087..9935)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983654.1"
                     /locus_tag="N8I87_RS31435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31435"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_263213769.1"
                     /transl_table=11
                     /translation="MFTLVRRVTALCAVGAALAACGTTSAPHAAHQAPSPPSASASPSR
                     PPILVPGPGGLTPVFTNGPRTQGKTVALTFDADMTADQGPRAAAGEHFDNPALIATLRN
                     LKVPATVFMTGRWADQYPAEARSLGNDPLFEVANHSYSHYAFTGDCYGLPTVGDDRMRT
                     DVERAYTAIRKAGVPHPMPYFRFPGGCYDQKALRALSGLGVTAVQWDVVSGDAFATDAD
                     AVTRQVLDGVKPGSVVVMHCTRSAAPTTEQVVRTVVPELRKRGFRFVKVSELIGETGGH
                     R"
     misc_feature    complement(9918..9933)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     misc_feature    9925..9943
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.0"
                     /tool="antismash"
     misc_feature    complement(9948..9961)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.91"
                     /tool="antismash"
     gene            complement(10040..10603)
                     /locus_tag="N8I87_RS31440"
                     /old_locus_tag="N8I87_31440"
     CDS             complement(10040..10603)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014628746.1"
                     /locus_tag="N8I87_RS31440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_31440"
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="WP_263213770.1"
                     /transl_table=11
                     /translation="MRRSFLIVLVAAMGLVQGCGSGTGDSSAPSPAPTPTASHRLTVTS
                     SAFAEGGTIPRRHTCDGEDVSPPLAFSGVPADTTGLVLVVEDPDAPHGTFTHWLVWNIG
                     PRTTELAAGQAPQGATQGRNGFRRTGYGGPCPPKGDSPHHYVFTVYAADRRLDLAADVS
                     PDDVRRALNGHALATGTLTGRYGR"
ORIGIN
        1 ggaccccgac atggtcgtcc tgcgcacctc gctggggcgg tacggcgagt cggagatcct
       61 cgagcacgag gacgcccacc tggtcgaggt gtcccggcac gacctgaggg cggccatcgg
      121 cctcgacgcc gcacccgtgc ggacggtcgt gacccgctgg accgacggcc tgccccagta
      181 ccccgtcggc caccacgcgc gcgtggcccg catccgcgag cacgtcgcca agctgccggg
      241 gctggccgtg tgcggagcgc agtacgacgg cgtgggcatc ccggcctgca tcgcgagcgc
      301 gtacgccgcc gtggaccggc tgggcggcga tgcgagcggt gtgcgggacc tcaccgccga
      361 ccccgtgcag agtcttcacg gtggcgcggg agaataaggg acatgagtga cgacgcaccc
      421 acccccgaga ccggcaggat cccgaacaag ggcaagctgg ccaaggacct caacgaggtc
      481 atccgctaca ccctgtggtc cgtcttcaag ctgaaggacg tgctgcccga ggaccgcgcg
      541 ggttacgcgg acgaggtcca ggagctgttc gaccagctcg ccgcgaagga cgtgaccatc
      601 cgcggcacgt acgacctgtc cggtctgcgt gccgacgccg atctcatgat ctggtggcac
      661 gccgagagca gtgaccagct gcaggaggcg tacaacctct tccgccgtac gaagctgggc
      721 cgcgcgctgg agccggtctg gtcgaacatg gcgctgcacc gtccggcgga gttcaaccgc
      781 tcgcacatcc cggcgttcct cgccgacgag acgccgcgca actatgtcag cgtgtacccc
      841 ttcgtgcgct cgtacgactg gtatctgctg gccgacgagg accgccgccg catgctcgcc
      901 gaccacggca agatggcccg cggcttcccg gacgtccgcg ccaacacggt cgcctcgttc
      961 gcgctcggcg actacgagtg gctcctggcc ttcgaggccg acgacctgca ccgcatcgtc
     1021 gacctcatgc gccacctccg cggcgcggag gcccgcatgc acgtccgcga ggaaatcccg
     1081 ttctacacgg gccgccgcaa ggagatcaca gaactgatcg cgggcctcgc ctgaccgggc
     1141 gcggagctgt gtgggccagc ccgcgagggg gctcggggag ctgatcgcgg gtcggcctga
     1201 cgggccccgg tgtttcgcgg gtcggcccgc gaagaggccg gtgaggtgat cgcgggcttg
     1261 tgcgatcggg tgcggcgtct tccgggtcgg ccgggttttc cccgggggat gcgcaccggt
     1321 cggcgcgcgg tggtcggcga gtcgatcgcc ggacttgccc gacccgacct gtggggctca
     1381 tcggtgtcgt ctgggcccgt gagggctcag tgttggtcgg cctttccctt cagggcgtct
     1441 ctttgggacg gagttcgggg cttcggttcc gggtgggcgg cgcaggacgt gtggcggttc
     1501 gggaggcggc cctccaagag gtatgcgtcc aggtgggcgt tgacgcactg gttcgggccg
     1561 cccgcgacgc cgtgcgtacc ggcgtcccgc tcggtcacca ggaccgagcc ggccagccgc
     1621 cggttcatct ccagcgcccc gtcgtacggc gcggcagcgt cccgctcggc ggccaggatc
     1681 agcgtcggcg gcagctcgtc cggcccggtc cgcacgtcga gcggcgcctg ccggggcgtc
     1741 ttccagtagg cgcacggcag attcgcccat gcgttgtccc aggtctcgaa gggcgccacg
     1801 cgcgccagcc gggtgttgtc gcggtcccag accgcccagt ccgtcggcca gggggcgtcg
     1861 ttgcactcga cggccgtgta caccgcgctc gcgttctcgg cctcggcggc cgtccccgtc
     1921 ccgccggccg gcgaggcgat cttcagcagc ggcccggtgt cgcccttcag atacgccgac
     1981 agcgcctcgg cgcggctcgg ccagacatcg tcgtagtacc cggccatcag gaacgcgccc
     2041 tgcaactgcc ccggcccgac cttgccgccg gccggctccg cggccagcgc cgcccgcgcc
     2101 cggtcgtagc tgcgctgcac cgtctcggcc gtggcaccca gcccgtacgc gtcgtcgtgc
     2161 cgggcgaccc actcacggaa gtcggtccag cggttctcga acgcggccga ctgctccagg
     2221 ttgctgcggt accagatctg cgccgggtcc gggttcacgg ccgcgtccag caccatccgc
     2281 cgtacgtgcg aggggaacag cgtcgcgtac acggccccga agtaggtgcc gtacgacgcg
     2341 cccatgaagg tcagcttctc ctcgtccagc gcggcacgca gcacgtccag atcacgcgcg
     2401 ttgttgagcg agttgtagta ccgcagtccg ctcccggcgc gcttggcgca gtcgtgcgcg
     2461 tacgccttcg cctccgcgat ccgctccttc ttgtacgact ccgaggggtg cgtcggcgcc
     2521 tgcgagggcc ccttgaagaa ccggtccggg gcctggcagg acagcggcgc cgaccggccc
     2581 accccgcgcg gggcgtatcc gacgaggtcg tacgcggccg cgatccgctg ccactcgggc
     2641 agtgcgccga cgagcggaaa ggccatgccg gaggcgcccg gaccgcccgg gttgtagacg
     2701 agcgagccct gccggggcac cttccgcttg ctgttgcgcg ggtccttgtg cgtggccgcg
     2761 gtccggctca cggtcagctc gatctgcttg ccgtcgggat gcgcgtagtc cagcgggacg
     2821 cgcaccgtgc cgcaccgcag gctgtccgga aggccctccg ccgcggggca cttcccgaac
     2881 gcgatgcctt ccgcacgggc acgcgcggcg gtgaccgccg tgccgcgcgc ctcggtcacc
     2941 gcgcccggca cacccgaagc accgggcgcg cgcgcgccgc cggcgcggcg acgagggcgg
     3001 tcagcagcaa cgacccggcg gccgagtaga gggcggcagc tcgcatggcg tatcccttcg
     3061 gtgcgccgcg gcacggacac cgcggcaaca aaagggatat ttcgttcggg cctcggcgaa
     3121 ggcaagcacc atcccgccgg tgtcggcgtc aatactccct gtgcgccccc gcgcggacgc
     3181 cgtcactccc gccagggctg gtcgcgatgg gcgaacgccg cgcgcagctc cggttcgccg
     3241 atcgcgcgga ttccgcgcac ggcgacggag gtcagatagg tgcggtcgtc accggacccg
     3301 gtcgcccgcc gggtcagcgc gccgagcagc cgctgcccgg caggcgaggc ccagcgcgag
     3361 tacgggtgca cctcgacccg ggcgatggcg aggcagctca gggtcagggc gaaggggagc
     3421 gcgaaccagg cggcgaccag atcgcgcggc atgtcggtct gagccggcat cagcagcgcg
     3481 gtcgcgccca gggcggcgac ggccaccgcg gccagccgga cctgacggac cccggacgcc
     3541 acggtcgtac gcgccccgtc gggcaccgcg agccccgccc ggaccagccc gtcggcgatg
     3601 ctgcgcacgg cgtcggcccc ggccgcggcg gagcgcacgg gctcgatgcg ggactggccc
     3661 tccggcccta tggcccctat gacggaccgc tccatctcgt cccggccccg tgggtccacg
     3721 acggtcgccc agccggtgtg cgcgagcagc agccggcgct gccgggccat ggagaccatg
     3781 gtgagatcgg cgacccgcgc gggcccgccc gacaggaacg ccgcctcgta cagcgtcagg
     3841 tcgtgccccc ggtccgcggt cgcaccctcc gcgtcgacgg ccgccaggcg tacggcggcc
     3901 aggcacaggc gcgtacacgc cgtgcccgcg acggcccagg ccagcagcag gagaaggacc
     3961 cagaacatga cgtttttcta tgccaggggc ctgggaaacg ccatgccctt ttcaccatcc
     4021 ggacggagtg ttgtcggtac gtgacgttcc gcttctcggg cggatcagga gccgtcgccc
     4081 ggcggcgggc tggaggcggc cggcggaagc gggtacgtgg gcgagggcga ggagccgatc
     4141 ggagtcgccg agcccggctg gaccaccggc ggcgacggca cgggcgaggc ggcggtcgcc
     4201 aagtcccggg ccagtgcggc gaagtccacg tagccggtcg cctccagcat cctgatgtga
     4261 tccagcacgg tggtgtcggc gtcgtcggcg agatcgcgga ccagcgagtt ctgggtgccg
     4321 gcccggacct gggcgacgac cgagaacacc ctgccgtggg ccagccgcag gatgttggcg
     4381 aactcgcgat cgaagtcctg cccctgtgcc gtgctcaggg tggtgagcca ctgcttctgc
     4441 tgctcgttgg gctcgttggg cagcggcagg ccgagccggg tggcgacgat gagggcatgc
     4501 gcgtccagcg acgtgtgccc cgccacgagg tgtcgcccgg ccgcccgtac ggcctcggtc
     4561 gtgcccttcg tctcggccag ctgtccggcg ggcagttccc acagcccggc cagtcggacc
     4621 ttggtgacga agtcccggtc cgcctgggac agggggccgt actgggtcgt cacggtctgg
     4681 gcgttcagca cgtcggcgcc ggtgccgccg gtaccggcga tgccggtccg gtccgcgtac
     4741 gaccagacgg gaaacagcag cgccgccagc gtcgcggcca ggcccgtgat gatgagcccg
     4801 agcccgctga aaatgcctct gcccttgatc gggggtcggg gtcgcggtcg catggtgcct
     4861 cctgcttgcg gcaccgcacg ccagtgcgct tcgggtgggt gcgggttggc atattactgc
     4921 ggagtcagtg ccaaccaccg tgcgggcagg gggatataag gtatgcgaac ccatcaaata
     4981 gggcgccggt gttgcggctg tcaccttctc cgcagcagca ccctccgcgc cgcccgggcc
     5041 gcccgcacca ccggccgtcg cgaccggggc accggccccg accgctccag ccaccactcc
     5101 cgcagttccc gccgcacccc cgcgtcctcg atccgtcccg cgagcaactg ccccgcgaag
     5161 tccagcgcgt cctgtcggta accaccggcc atcgggtgcc cgtgggcgta gtcgaggaac
     5221 gccggccggt actccgtccc cagaatcacc ggcagctcgg gcgcgatctt cgccaccacg
     5281 gacgcccgct tcgcggccag tgcccgcgcc tgcaccccca tccgcacccg gtcgaacccc
     5341 tcgggcacgg gcgtcccggc gaccagcgac gacagcaccg cggtctgcgc gagcgcgagc
     5401 cgctcccggg tgtcgtcgtc ggcgacgaca acgggcgggg tcacggcgcg gacccgcgac
     5461 gccgccccgg aaacggagcg tatcgcacgc ccctcctgca ccgccccgga aacggggcac
     5521 atcgcccgcc cctcctccac cgccccccga atcgactcca actcccgctc cagctcaccg
     5581 ggttcgggga agttctcgtc ccgctccagc agcacgccgg gcggcgcgac ccgcgaggcg
     5641 aggtcggtca ggatgtcgag caccggccgc ggtacggggt gggcgtggct gtcgtgccag
     5701 acgccgtcgc gctcgaagcc gcccgcgaca tgcacatacg cgacggcctc cagcggcagt
     5761 tcggccagcg ccttggccgg gtcctcgccc cggttgacat ggttggtgtg cagattcgcc
     5821 acatcgatga gcagccgcac cccggtccgc tcggccagct cgtacaggaa ctgcccctcg
     5881 gtcatctcct cgccgggcca ggagatcagc gcggctatgt tctcgacggc gagcggcacc
     5941 ggcagcgcct cctgggcgat gcgcacgttc tcgcacagca cgtcgagggc gtcccgggtg
     6001 cggggcaggg gcagcagatg gcccgcctcc aggcgcgggg aggcggtcaa cggcccgccc
     6061 gcccgtacga acgcgatgtg ctcggtgacc agcggcgcgc ccagcgccgc cgcccgctcg
     6121 gcgagcgcgg tcagccgccc ctcgtcgggc cggtccgcac cgccgaggcc gagcgagaca
     6181 ccgtgcggca ccacggtcac tccgcgctcg cgcagccgca gcagcgactc gggcaggtgt
     6241 ccgggacaga cgttctccgc cacggcctcc acccagtcga tgccgggcat gcgctccacg
     6301 gcgtccgcga tctccggccg ccagccgatc cccgttccca gtcgccgcat ggtccttccc
     6361 cctccttcgc gtgacggggg tatcaccccg gcgcccggcc ccgaaccccg ccgcccgcac
     6421 cttcagagca acatttgagg ttcacggcag agcgggatgt gaggttcgcg gcagagcggg
     6481 atccgaggtt cgcggcccgg aacccggccc gcacccggcc tacccgggca cgccccgcga
     6541 gtccaccgga tcccgccgca gcgccggatg atcggcgacc acggtgcagg aacccggcgc
     6601 gatctccgtg aagcccgcgt cccgtaccaa cggcagcccg ctgtccgtca gccggggcca
     6661 ctcggccggg tccgcggtgc gtaccgacag cgggaaaccc gtgtcgcgcc aggccgcgcg
     6721 gtcctcgtcg gacagctccc accaggcgag ttgggcgccg tgtccgacct gggccatcgc
     6781 ctttccggcc gacatgtcga gttcgggatt catccagagc acgggccgcg cacggtcggg
     6841 tccggccggc ggctccgggt cgtcgaggtc ggtgcccgac acctgcagct tggccaggtc
     6901 cttgggccag ccgtccagcg ggacgggtgg gaagacccgt atctgcgccg actcgccggt
     6961 caccgtgatc ccgggcagtg cctccgcgcg ccgccactcc gcgccacggg cccgccgtac
     7021 gaccttgcgg atccgggcgt cctgccagtc ccgtacggcc tcggcccact cgccgtcacc
     7081 cagcgcccgc tcgtcggcga gcagcgtcag cacggaacgc gcggcggtct ccagcgcatc
     7141 tgtacgggcg ggcggcgcac cgcgttcgat gcgcaccacc agcggcagca cgaactgcgg
     7201 cgcctcgtca cgcgcactgc gctcggaccg gaagggactg tcaccggggg atgtcgaaac
     7261 gtggctcaca acagccaacc ctaaagccgg accagaatag ccccatgcga cgtgatcttc
     7321 ggctggcccg cgtaggccgc cgctacggca tacgcggccc ctgggtgtta cgaggcatcg
     7381 acctcaccgt cacgcccggc tcgctcatcc gcgtggaagg agccaacggc agcggcaagt
     7441 ccaccctcct gcgcattctc gccgggctgg acgcgcccac ggagggccgt atcaccggcc
     7501 gcccccgcac ggcgtacgtc cccgagcggt tcccctcggc gctccccttc accgccgccg
     7561 gctatctcac ccacctcggc acggtccacg gcctgtcccg ccggacggcg gccggcgccg
     7621 ccgtcgcatg gctggaccgc ttcggcgccg ccgcccatgc cgacacaccg atggcccagc
     7681 tgtccaaggg cagcagccag aaggtcgcgg tggcccaggc cctgctcgcg gagcccgagt
     7741 tgctcgtgct ggacgaggcc tggacgggac tggacgccgc ggcccgggcg gaactggagc
     7801 gggcggtcgc cgagcgcacg gccgccggat gtgccgtcgt gttcgtcgac cacgacccgc
     7861 gccgcctggc cggggcgccc gacgagacgt acgtggtcac cgacggcacc ctcgaccgcc
     7921 gtaccgggaa cgagagttca ccggccggcc ggcacgccgt ggtcatcgcg cagggcccgt
     7981 cgggcggaca actgcccccc gacgccgcgc ggacggtcac ctcggccgag gagaccgcgc
     8041 cccgcaccca ccggctcacc gtccccgagt cccactccga cgtcctgctc cgtgccctgc
     8101 tgacggcccg cccgccctgg cacgtggtga gcgtgagccc cggtacaccc cccgagacgc
     8161 cgcccgatcc cgaaagccgc tcatgaccgc actcctgcgt taccaggccg cactcctcgt
     8221 acgctcccag cgctggctgc cacccgtcgt cctgtacgcg gccttcctcg ccgtcggcgt
     8281 gcagagcggc cagccggtgc tcgactcgct cggctacacg gccgctgcat tgctgccggt
     8341 cgccgcctgg ctggtgcgga tctgtgtcac caacgagccg cccgcggccc gcgcctgtgt
     8401 cgccgccgcg gccggaccgg ccagggccca cctcgcctgc cttttggcgg ctctcctcgc
     8461 gtcggcggcg ctcggcaccg tggcgaccct ggccgtgacg ctgatcagcg acccggcggc
     8521 caacggccat cgcgcccacg tcccacgctt cgaggcgggc gcggccgggc tgctggccgc
     8581 gctctcctgt gcgctgctgg ggacggccgt cggcgcgctc accaactggc cgctgctgcg
     8641 ctcgcccggc cgggcggtgc ccgcgatgct gctggccgcg ctgctgtcgg tggtcgtcgc
     8701 gggctcaccg gcgcaggcgg cggtgaacgg gctggtcacc ggctcgcagt cgggccgggt
     8761 cccggtgccg ctgctgccgc tggccgcggc ggccctgctg accgccgcgg ccttcgccgt
     8821 ggcctgcgcg ctcacccgtc gccggtcacc ctgagcaggc cgtgcgctgc gcctccggcc
     8881 tcccccgagt tctcgacttc gctcgaacag gggggacccc ccatgcagac cgggcacagc
     8941 gtggtgcccc tgtacgacgc ggggtactcc gtcggcttcc ggcacagcac gcactccgcg
     9001 tacggcggct cgtccgcggg ctgcgactcg gtggtgtcga tgatcgtgca gtagtcctcg
     9061 tcgctcatct cttcagggta ggccggtcag cggtggccgc cggtctcccc gatcagctcg
     9121 gacaccttca cgaaccggaa gccccgcttg cgcagttccg gtacgaccgt gcgcaccacc
     9181 tgctccgtcg tcggggcggc gctgcgggtg cagtgcatca cgacgaccga gccgggcttc
     9241 accccgtcca gcacctgccg ggtgacggcg tcggcgtccg tcgcgaacgc gtccccgctc
     9301 accacgtccc actgcaccgc ggtgacgccg aggccgctca gcgcgcgcag cgccttctgg
     9361 tcgtagcagc cgccggggaa acggaagtac ggcatcgggt gcggcacacc ggccttgcgg
     9421 atcgcggtgt acgcccgctc cacgtccgtg cgcatcctgt cgtcgccgac ggtcggcagg
     9481 ccgtagcagt cgccggtgaa ggcgtagtgg ctgtaggagt ggttggcgac ctcgaacagc
     9541 gggtcgttgc cgagggagcg ggcctcggcc gggtactggt cggcccaccg gcccgtcatg
     9601 aagacggtgg ccgggacctt cagattgcgc agcgtggcga tgagcgccgg attgtcgaag
     9661 tgctcgcccg cggccgctcg cgggccctgg tcggcggtca tgtcggcgtc gaaggtgagg
     9721 gcgacggtct tgccctgtgt gcgcgggccg ttcgtgaaga ccggggtgag gccgcccggg
     9781 cccgggacga ggatgggcgg tcgtgagggg gaagcggatg cggagggcgg gctgggggcc
     9841 tggtgggcgg cgtgcggggc actcgtggtg ccgcaggcgg cgagggcggc gcccacggcg
     9901 cagagggcgg tgacacggcg tacaagagtg aacaccgtat gaagatatga tcgtaaatat
     9961 gctcatccga tcgacgcgcc ctgtcggtcg tacgggagtc acccgcctgg ccgcgccccc
    10021 ggccgcccgc cccggccggt cagcggccgt agcggcccgt cagggtgccg gtggcgaggg
    10081 cgtggccgtt cagggcgcgc cggacgtcgt cgggtgagac gtcggcggcg aggtccaggc
    10141 gccggtcggc ggcgtagacc gtgaacacgt agtggtgcgg gctgtcgccc ttgggcgggc
    10201 aggggccgcc gtagcccgtc ctgcggaagc cgttgcggcc ctgtgtcgcg ccctggggcg
    10261 cctgcccggc ggccagctcc gtggtccgcg ggccgatgtt ccacaccagc cagtgcgtga
    10321 acgtgccgtg cggggcgtcg gggtcctcca ccacgaggac cagtccggtg gtgtccgcgg
    10381 gtacgccgga gaaggcgagc ggcggcgaca cgtcctcgcc gtcgcaggtg tgacggcgag
    10441 ggatcgtgcc gccctcggcg aacgcggagc tcgtcaccgt gaggcggtgc gaggcggtgg
    10501 gggtgggggc cgggctgggg gcggacgagt cgcccgtgcc gctcccgcag ccctggacca
    10561 ggcccatggc ggccaccaac acgatcagga agctccggcg catgcccgga acgttagctc
    10621 cgggggaccg cggagtcacc gatgccggtg ggttgttgcg tgccgtcgat ggcgggggac
    10681 tgctgcgcgt cgtcgctgcc gtccggttgt ggcggttcgc cttgttccag gtcaccgtcg
    10741 gcggccgccg gttgcgagcc ggtgattccg tccggctggt gcgactcggc gagcgcggcc
    10801 ggctgctggc ccctctccag gaagcgcagc agctccaccg ggatgggcag caccagcgtg
    10861 gagttcttct ccgccgccac cgccatcacc gtctgcagca ggcgcagctg cagtgcggag
    10921 ggcgtgtcgg ccatctgctg cgcggcctcg gccagcttcc tggaggcctg gagctcggcg
    10981 tcggcgttga tgatcctcgc ccggcgctca cggtcggcct cggcctgacg ggccatggag
    11041 cgcttcatcg cgtccggcag ggagacgtcc ttgatctcga cccggtcgat ctgcacgccc
    11101 cagccgatgg cggggctgtc gatcatcagc tccaggccct ggttgagctt ctcgcggttg
    11161 gagagcagat cgtcgaggtc gctcttgccg atgatcgagc gcagggaggt ctgtgccatc
    11221 tgggagacgg cgaagcggta gtcctcgacg ttgatggtcg cggccgccgc gtccacgacc
    11281 ttgaagtaca cgaccgcgtc gacccgcacc gtcacgttgt cccgcgtgat gccctcctgg
    11341 gcgggcacgg
//
