LOCUS       NZ_CP106798            21853 bp    DNA     linear   CON 01-NOV-2023
DEFINITION  Streptomyces sp. HUAS 15-9 chromosome, complete genome.
ACCESSION   NZ_CP106798
VERSION     NZ_CP106798.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. HUAS 15-9
  ORGANISM  Streptomyces sp. HUAS 15-9
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9258818)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 169.8x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/01/2023 03:42:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,774
            CDSs (total)                      :: 8,679
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 95
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 504
            CDSs (without protein)            :: 504
            Pseudo Genes (ambiguous residues) :: 0 of 504
            Pseudo Genes (frameshifted)       :: 260 of 504
            Pseudo Genes (incomplete)         :: 328 of 504
            Pseudo Genes (internal stop)      :: 29 of 504
            Pseudo Genes (multiple problems)  :: 107 of 504
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:51:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2421879
            Orig. end                         :: 2443732
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106798.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21853
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21853
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21853
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11853](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11853
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(728..742)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            complement(841..2034)
                     /locus_tag="N8I87_RS11100"
                     /old_locus_tag="N8I87_11100"
     CDS             complement(841..2034)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004001879.1"
                     /locus_tag="N8I87_RS11100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11100"
                     /product="hypothetical protein"
                     /protein_id="WP_263207856.1"
                     /transl_table=11
                     /translation="MAGRRRAWRSGVVGLCLLLVPLTGCGGGRTGADSARTEVQQMLDR
                     RAAALLGHDEAAYDRTGSRTQYENLHTVPLDSWTYRLTGLHRTGSTATAAAELRYRLRG
                     IDTAPVTTGRTLTLRHRADGQWYVAADRPAKKAAQQLWDQGAVTAVKGGHSLILGVGQS
                     ATALHTYARLADRAVPAVSQAWGTHWTRRVVVLVPKSLEGMAGVLGSPASSYRGIAAVT
                     TGEAGGSGRAPADRVVINPEAYALLGDVGKQVVLTHETTHVATRADTTPATPLWLSEGY
                     ADWIGYLGTGRTPAEAAPELARAVQENRVPPDLPTDKDFGFDSDPTRLAQAYETGWLAC
                     RMIADHWGELRLAEFYRTVGTHGKRAGAVEAALRKVLGTTPEQFTTQWQDYVRAQLG"
     gene            complement(2064..3074)
                     /locus_tag="N8I87_RS11105"
                     /old_locus_tag="N8I87_11105"
     CDS             complement(2064..3074)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016435799.1"
                     /locus_tag="N8I87_RS11105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11105"
                     /product="NlpC/P60 family protein"
                     /protein_id="WP_263207857.1"
                     /transl_table=11
                     /translation="MGSHRRLVPSGFNRGAVVLCVLSAAAAALGAVPAAAAPHGDPRAE
                     VDRLYQEAENATEAFDRAGERAGVLRRQVSDAQDHIARQQERINTMRDELGSLAGAQYR
                     SGGIDPTVALLFSDDPEDYLDKAATLDRIGAHQAGRLKELQSALRELAQERSETVGKLT
                     ELERSRKAVASHKRTVEKKLAEARKLLNSLPDAERAAYERATRGARQYMPELSGSAAPA
                     GRAAAALAAARSALGRPYVWGANGPSGFDCSGLMQWSYAHAGVQLPRTSQEQRYAGRRI
                     PLSQVRPGDLVVYRSDAGHVAMYAGNGQVIHAPHPGAPVRYDPVGMMPISSVTRV"
     gene            complement(3272..4303)
                     /locus_tag="N8I87_RS11110"
                     /old_locus_tag="N8I87_11110"
     CDS             complement(3272..4303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062379.1"
                     /locus_tag="N8I87_RS11110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11110"
                     /product="NlpC/P60 family protein"
                     /protein_id="WP_263207859.1"
                     /transl_table=11
                     /translation="MASHRRPKQPSRTRVTVLTTAAAAAVALSANAANAAPSEKLSKDE
                     VKAKVDKLYEQAEQATEKYNGAKEKQEKLQKEISTIQDNVARGQGDLNKLRDGLGSMAS
                     AQYRSGGIDPSIQLFLSSNPDDYLDKASTLDQLSSQQVEALKKIQDKQRELAQERAEAT
                     DKLKDLASTRTELGKKKKEVQGKLAEAQRLLNTLTAKEKAALAAEQSRASRSSTERVDL
                     GNDTSASGRAAAAFSAAQAQIGKPYVYGATGPSSFDCSGLTSYAYAQAGVSIPRTSQAQ
                     AGIGTRLSMSQLQVGDLVFFYGDLHHVGLYAGNGQVLHAPHTGAVVRYEAIGNMPFQFG
                     VRV"
     misc_feature    4424..4440
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     misc_feature    4490..4503
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(4510..4524)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.03"
                     /tool="antismash"
     gene            complement(4515..5858)
                     /locus_tag="N8I87_RS11115"
                     /old_locus_tag="N8I87_11115"
     CDS             complement(4515..5858)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661009.1"
                     /locus_tag="N8I87_RS11115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11115"
                     /product="NYN domain-containing protein"
                     /protein_id="WP_263207861.1"
                     /transl_table=11
                     /translation="MVETAGGGPGDGTAEVLDRPLPDGVRRRVVQIVSDGFGGLTVGEL
                     PAQLRQYARFAPNRRAKFAGNAMAAALETDALFRQRIGEKLREAQPELAGALDSGSPPP
                     AADPLDVAAAAYVLRPTGWVKLVTAAGEEAQRADAERADEESRAELERLREELDHAREQ
                     TRAETERLRTELETAKKEAESLHRKLRAALSDVKRGEAALRKVQGEIEAVRAEGNAQVS
                     TAESETRRLKARLGEAEAALEATRRAAREGRSVEDMRVRLLLDTVLEAAQGLRRELALP
                     PVSVRPAETVDAVEPGRMTPKDIAARALSDSDPAILDQLLALPQAHLVVDGYNVTKTGY
                     PQMPLEKQRLRLLGQLSQLAAQTGAEVTCVFDGAELAAPVLLAPPRGVRVLFSKPGVTA
                     DELIRQLVRAEPPGRPVIVASTDREVADGVARAGARPVASAVLLKRLS"
     gene            complement(5923..6162)
                     /locus_tag="N8I87_RS11120"
                     /old_locus_tag="N8I87_11120"
     CDS             complement(5923..6162)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522002.1"
                     /locus_tag="N8I87_RS11120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11120"
                     /product="hypothetical protein"
                     /protein_id="WP_263207863.1"
                     /transl_table=11
                     /translation="MPVPLPTATTRWRCSLCGNLTRFDVTRASKVVEYVHLDLAGEPKV
                     EEREVVSETIESVRCRWCNAVDQVELVDRPGADS"
     gene            6318..7043
                     /locus_tag="N8I87_RS11125"
                     /old_locus_tag="N8I87_11125"
     CDS             6318..7043
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067816.1"
                     /locus_tag="N8I87_RS11125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11125"
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="WP_263207865.1"
                     /transl_table=11
                     /translation="MISNWGTVAGRTFRAVRGTPAPMTYTFIALCCLIFVMGPASGLNP
                     AYGTGDALLAVQRAYFRHWGVIPAKLFEQPAQEALTPATALFVHGSWVHLLGNMLFLYV
                     FGAMTEERMGRVQFTLFYVGCGYLALIGYAAANASSQQSLVGASGAISAVLGAFLYLFP
                     DARVTSLLPFLFFLPLRFPAWVVLPFWAAVQWLAAGRASQGPGVAYLAHLVGFSLGFLF
                     AWVRFGRRVRGAVPDSGGG"
     gene            complement(7161..8312)
                     /locus_tag="N8I87_RS11130"
                     /old_locus_tag="N8I87_11130"
     CDS             complement(7161..8312)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954631.1"
                     /locus_tag="N8I87_RS11130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11130"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_263207868.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.4e-27, bitscore:
                     95.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2e-23, bitscore:
                     81.3, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.6e-40, bitscore:
                     137.0, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRTVFQDEHEAFRAVVRGLIEAEVVPVYSEWETAGRVPRDLYLK
                     LGKLGIFGFGIPEEFGGSGEKSFKFNAVIAEECARAGVTFGGASAHLALPATLVNYTTP
                     EQKRRWLPGFVTGELMTAIAITEPGAGSDVAGLRTAAELAEDGSHYLLNGSKAFVSGGA
                     QADLVLVACRTSADRSDRRGGMSLLAVDTRAPGVTVDSEPVTLGLRSSDIVQMTFTDVR
                     VPVGDVLGEPGGAFACLADIFPQERLGIAVGAYAQAAAAVHLTTEYVRERTAFGKPLAA
                     FQNTKFVLADCKVTVNALQAVVDQALDAFDSGELTAEEAAATKLYCTETAVRVLDKCLQ
                     LHGGLGFTMDHPIARLYADNRASRIFGGTSEIMRTIVAKSMGL"
     misc_feature    complement(8187..8189)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8253..8255)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8414..8430
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    complement(8422..8438)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.94"
                     /tool="antismash"
     misc_feature    complement(8594..8607)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    complement(8670..8684)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            8744..9718
                     /locus_tag="N8I87_RS11135"
                     /old_locus_tag="N8I87_11135"
     CDS             8744..9718
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.3"
                     /locus_tag="N8I87_RS11135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11135"
                     /product="cytochrome P450"
                     /protein_id="WP_263207869.1"
                     /sec_met_domain="p450 (E-value: 4.7e-33, bitscore: 113.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAARSWMLMRDGEAHRRLRGLANPLFTARAIRETAPRIAGIVHR
                     IMDDMGDGRDIDLIGQLAALVPVTVFCGLGGLPVEDRDLCRKWTDALGHVIDPATDETT
                     RRAMNDAAEEFGAYVAGHLEERRANPRDDIISRLLLAEFDGEKLSDEEIVANVMMFFMG
                     GHETTVNLIGNGMLALLRHPDQLRALREDPGLVENGIDELLRYDAPIQLVARITTDDIE
                     LEGTTIPAGSKVMILLGAANRDPARYPDPDRLDLRRPDVRPLSFGGGPHYCIGALLAKT
                     EARLVLTELLRRHRDITLSREDVVWRPQVNIRGLRELRVDLLS"
     misc_feature    9875..9889
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.65"
                     /tool="antismash"
     gene            10001..10939
                     /locus_tag="N8I87_RS11140"
                     /old_locus_tag="N8I87_11140"
     CDS             10001..10939
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004186.1"
                     /locus_tag="N8I87_RS11140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11140"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_263207871.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.9e-51, bitscore:
                     172.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLEEFMVGGKRIRPMLTVMGWKAAGGETDLTAVVRVAASLEMF
                     HAFALIHDDIMDDSDTRRGRPTIHRMLAGKRGDDRTERFGIGAAVLLGDLAFAWSDQLL
                     HTADLTSAQSAAVLPLVTDMRTEVMLGQYLDLRATGELTDDVDATLTVNRYKTAKYTIE
                     RPLHIGAALAGAGTDALAACSAFALPLGEAFQLRDDLLGVYGDVRDTGKSRLDDLRAGK
                     NTTLVALALRAGDTAQRARLRALIGDPGLDEAGAEEVRALFASTGARDAVEHMIDDRYR
                     QAVRALETAPFTAAAVTALKQLAVTATRRNS"
     misc_feature    complement(10005..10019)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.21"
                     /tool="antismash"
     gene            10936..11853
                     /locus_tag="N8I87_RS11145"
                     /old_locus_tag="N8I87_11145"
     CDS             10936..11853
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188168.1"
                     /locus_tag="N8I87_RS11145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11145"
                     /product="terpene synthase family protein"
                     /protein_id="WP_263207873.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-12, bitscore: 46.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADLTAPATTAPAGTARHWQECTDRFAALFERHVGYEARKVPMT
                     DAELREVIDACNRAVAPLGKSVSDKRWISYMDVVRWSQSARHIKDMEAFKAVCVLNCVT
                     FVWDDMDAALHDFDLFLPQLRAVCERYYSAEDAEFAYEGARAFVTSDHMFRDSLLKKVL
                     CSTSPEQYFRFRVTDVGVDFWMRMSYPIYRHRELTEHSKTGLAARMTTRGLAIVNDFYS
                     YDREHALGQITNCFRLCDMADDAGFRHFFQARLDDMAEDMECIKAFDDITRDVLLDLIQ
                     GNFVWTTRDRRYQAPVNDVNSRIQ"
     gene            11864..13222
                     /locus_tag="N8I87_RS11150"
                     /old_locus_tag="N8I87_11150"
     CDS             11864..13222
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000061: Hydroxylation (78% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058777.1"
                     /locus_tag="N8I87_RS11150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11150"
                     /product="cytochrome P450"
                     /protein_id="WP_263207875.1"
                     /sec_met_domain="p450 (E-value: 7.3e-78, bitscore: 261.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSKSPAAAGHWRIGTAPGALPLLGHVPALWRRPLEFLASLPAY
                     GDLVEVRLGPGRAYLAAHPELVRHVLLNPRVFDKGGVFDKARQLLGNSLSVSRGEEHRF
                     QRRLIQPAFHPTRIAAYTTAVAEDTRAVTDAWQAGKTLDISDAMHALLMRVAARTLFST
                     GLDDATIEEARQCLRTVSHGIYKRTVAPLGIMEKLPTPGNRAYDHANARLRQIVADMIA
                     LRRRSDTDHGDLLSTLLRAEHPETGEKLDDGQILDQVVTFLVAGSETTASTLAFVFHLM
                     GTLPEVEKRVHAEVDAALEGRTPVYDDLPALPYTRNVITEALRLYPPSWMAMRVTAQDV
                     ELGGRLIPARTMMLYSAYALHHNPELFPDPESFDPGRWEGERAERVPRGALLPFGAGSH
                     KCIGDVLALTETALIVATVGARWRLRPAPGSRLRPEPKATLESGPLPMVLERR"
     gene            13313..14671
                     /locus_tag="N8I87_RS11155"
                     /old_locus_tag="N8I87_11155"
     CDS             13313..14671
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000062: Hydroxylation (74% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188170.1"
                     /locus_tag="N8I87_RS11155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11155"
                     /product="cytochrome P450"
                     /protein_id="WP_263207877.1"
                     /sec_met_domain="p450 (E-value: 4.3e-78, bitscore: 262.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTQSDLARRGWRIAKAPGRLPLVGHALHLARRPLEFLASLPAVG
                     DLVELRLGTKPTYLPCHPELVQQVLLNARVYDTGGPVKEKARPILGNGLITSDWADHRR
                     QRRMVQPAFHTARIATYAEVMREECAAHTETWRAGRPLDVGDAMQALTARVTARALFST
                     EMAPHSVAEIQRGLPVMVRGAFRRAMDPTGLLARLPLAANREFDTALARLHALIDTIVG
                     DYRRSGEDRGDLLSALLAARDEEDGGAMTDQEVHDQVMTLLLAGVETTASALTWAWHLL
                     AAHPEAEARLHAEVDGVLGGRIPGYADVPRLAQTQRIFTEALRLYPPAWMYTRMTTEPT
                     ELAGHRLEAGSDLLISPYVIHRIPEFFPRPEVFDPDRWLPERARDVTRGSYLPFGGGSR
                     KCIGDVFGMTEATLALATIASRWRLRPVPGTTVSPHAGMSLTTGPLPMAPEPR"
     gene            complement(14696..15808)
                     /locus_tag="N8I87_RS11160"
                     /old_locus_tag="N8I87_11160"
     CDS             complement(14696..15808)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980739.1"
                     /locus_tag="N8I87_RS11160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11160"
                     /product="cytochrome P450"
                     /protein_id="WP_263216385.1"
                     /sec_met_domain="p450 (E-value: 8e-22, bitscore: 76.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAKGPVHRVRTSASGEFWLVVGHEEARSALADARLSNDIRHSAG
                     WQDDGGNAIGLNMVQTDPPQHTRLRGLVAKDFTPRRIEALRPKIQRIADELVDAMLPLG
                     RADLVEAFALPLPLAVICELLGVPANDRKTFHDWYLESTDFTRPEAAGAAAQAMTGYLA
                     DLIAAKRQEPGEDLLSALAGHMGEEEDRLSFEEMLGMAFLLLVAGYETAANLLSSGTLA
                     LLRHPDQLAALRADWSLLENAVEEMLRYDGPVETTAFRYAKEPVEIGGTVIGAGDSVAV
                     VLAAASRDPRRFARSDRFDIRRDARGHMAFGYGIHHCLGAPLARVQGAIAFRTLLERCP
                     GLALDTEPDAVVWRPSLMLRGPHHLPVTFG"
     gene            16006..16710
                     /locus_tag="N8I87_RS11165"
                     /old_locus_tag="N8I87_11165"
     CDS             16006..16710
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058778.1"
                     /locus_tag="N8I87_RS11165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11165"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_263207879.1"
                     /transl_table=11
                     /translation="MASGEDRRTPRRSDARRNRETLIAAAREIYAERGVDAPLDDIARR
                     AEVGNATLYRHFAGRAELIEAVFHDALTPILALARQTRERADAWSGLTAYLDHVFALLA
                     ADRGAGDLMTTGIQGVPTLDALREENHRTLETLLRRGQAQGTIRADLTVEDLLFLLAAL
                     GRAAPAAPGSWRRHLALLLDGLRPAGAHPLPAPPLGPEEFDAALHRLGTAPRAPARREP
                     PPSPPTSETSTP"
     gene            16707..18035
                     /locus_tag="N8I87_RS11170"
                     /old_locus_tag="N8I87_11170"
     CDS             16707..18035
                     /NRPS_PKS="Domain: Condensation_LCL (12-157). E-value:
                     1.4e-12. Score: 39.2. Matches aSDomain:
                     nrpspksdomains_N8I87_RS11170_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF028221.3"
                     /locus_tag="N8I87_RS11170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11170"
                     /product="hypothetical protein"
                     /protein_id="WP_263207881.1"
                     /sec_met_domain="Condensation (E-value: 3.5e-07, bitscore:
                     28.5, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRQRPISPFESVYFLDLGAAGLPLYDMPEFVESLVRGRPDITLT
                     RRALGLLTEHHPILRSEVTSGEGGLLLRVRDRVQPPLTVLDGIEDTYAELINSRPDWTE
                     SLLHAWLLTDGERSQVVLGVHHGVADGRSAFALLDEFWQYYTALAAGADPSPERREALP
                     EAIDTRLAGAFPDAEIDALVDAIAQGAAADAKPATLPTDGLGRPDRPAEARRFVVDRLE
                     FAPRTTEAVVDAARARGVTVNSLVTGLVMTAVRAQLAPEYGPLTMTCGHGVDLRTRLTP
                     QLPLSSVLNCITGLQTTLAVRYDDRPETVGREVAGQVASSLDRRDPERFLLAALRAGAR
                     GIAVPVPVVTYGISNVGRIPAHPVPEDMELLRFGGTANAPGMPPKIGVASFGGRLLVQN
                     EYDSWTYGPEQMRTLRETLRASLTDLVTDRVRATPGPEGENQP"
     aSDomain        16743..17177
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_N8I87_RS11170_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.40E-12"
                     /label="N8I87_RS11170_Condensation_LCL.1"
                     /locus_tag="N8I87_RS11170"
                     /protein_end="157"
                     /protein_start="12"
                     /score="39.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHGVADG"
                     /tool="antismash"
                     /translation="VYFLDLGAAGLPLYDMPEFVESLVRGRPDITLTRRALGLLTEHHP
                     ILRSEVTSGEGGLLLRVRDRVQPPLTVLDGIEDTYAELINSRPDWTESLLHAWLLTDGE
                     RSQVVLGVHHGVADGRSAFALLDEFWQYYTALAAGADPSPE"
     CDS_motif       16815..16889
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_N8I87_RS11170_0001"
                     /evalue="5.30E-03"
                     /label="C2_LCL_024-062"
                     /locus_tag="N8I87_RS11170"
                     /protein_end="61"
                     /protein_start="36"
                     /score="9.2"
                     /tool="antismash"
                     /translation="RGRPDITLTRRALGLLTEHHPILRS"
     CDS_motif       17076..17141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_N8I87_RS11170_0002"
                     /evalue="2.10E-04"
                     /label="C3_DCL_135-156"
                     /locus_tag="N8I87_RS11170"
                     /protein_end="145"
                     /protein_start="123"
                     /score="14.0"
                     /tool="antismash"
                     /translation="VHHGVADGRSAFALLDEFWQYY"
     gene            18032..18313
                     /locus_tag="N8I87_RS11175"
                     /old_locus_tag="N8I87_11175"
     CDS             18032..18313
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007828132.1"
                     /locus_tag="N8I87_RS11175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11175"
                     /product="Lrp/AsnC ligand binding domain-containing
                     protein"
                     /protein_id="WP_263207883.1"
                     /transl_table=11
                     /translation="MITAIVLIKTSVDRIPEIAESIASLDSVSEVFSVTGTYDLIAMVR
                     VKEHEELAEVIPGRISKIPGVEATDTHVAFRTYSQHDLEAAFSIGLDN"
     gene            complement(18427..19788)
                     /locus_tag="N8I87_RS11180"
                     /old_locus_tag="N8I87_11180"
     CDS             complement(18427..19788)
                     /NRPS_PKS="Domain: Aminotran_5 (37-426). E-value: 3.7e-77.
                     Score: 251.6. Matches aSDomain:
                     nrpspksdomains_N8I87_RS11180_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020137394.1"
                     /locus_tag="N8I87_RS11180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11180"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_263207885.1"
                     /sec_met_domain="Aminotran_5 (E-value: 7.1e-74, bitscore:
                     247.9, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.3e-06, bitscore:
                     26.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVSTAAAAQTICSPLPVLGGDVTVPLVTGGEVTYAALDYAASAP
                     ALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTDLFENARRTVAEFLDCRADDQVIFTRST
                     TDSLNLLAAALPADCQVFVFETEHHASLLPWKDARVSYLDAPRSPREAVATLERALADR
                     DPHGPALVCVTGASNVTGELWPVRELAAAAHAHGARIVLDAAQLAPHHPVSVQDLDVDW
                     VAFSGHKLYAPFGSGVLAGRADWLRAAEPYLAGGGASRGVSRRADGGVAVDWHETAARH
                     EAGSPNVIGVYSIASACKALTEAGFDTLVAREEYLIRKVRAGLAEVPQVRVLSLFGDDA
                     PRVGVISFVVEGWNSSHFAAALSAEYGIGVRDGLFCAHPLVRTLLGGDPQAQGECGAPE
                     AAPGEKSLNAVRVSFGAGTPDEHVDRFVNAVKELVQDGAKWQYRTEDGRCVPAV"
     aSDomain        complement(18511..19677)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_N8I87_RS11180_Aminotran_5.1"
                     /evalue="3.70E-77"
                     /label="N8I87_RS11180_Aminotran_5.1"
                     /locus_tag="N8I87_RS11180"
                     /protein_end="426"
                     /protein_start="37"
                     /score="251.6"
                     /tool="antismash"
                     /translation="LDYAASAPALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTDLFENA
                     RRTVAEFLDCRADDQVIFTRSTTDSLNLLAAALPADCQVFVFETEHHASLLPWKDARVS
                     YLDAPRSPREAVATLERALADRDPHGPALVCVTGASNVTGELWPVRELAAAAHAHGARI
                     VLDAAQLAPHHPVSVQDLDVDWVAFSGHKLYAPFGSGVLAGRADWLRAAEPYLAGGGAS
                     RGVSRRADGGVAVDWHETAARHEAGSPNVIGVYSIASACKALTEAGFDTLVAREEYLIR
                     KVRAGLAEVPQVRVLSLFGDDAPRVGVISFVVEGWNSSHFAAALSAEYGIGVRDGLFCA
                     HPLVRTLLGGDPQAQGECGAPEAAPGEKSLNAVRVSFGAGTPDEHVDRF"
     misc_feature    19747..19760
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.46"
                     /tool="antismash"
     regulatory      complement(19950..20066)
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00634"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00634"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="SAM riboswitch class IV; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(20140..21204)
                     /gene="trpD"
                     /locus_tag="N8I87_RS11185"
                     /old_locus_tag="N8I87_11185"
     CDS             complement(20140..21204)
                     /EC_number="2.4.2.18"
                     /GO_function="GO:0004048 - anthranilate
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987457.1"
                     /locus_tag="N8I87_RS11185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N8I87_11185"
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="WP_263207887.1"
                     /transl_table=11
                     /translation="MSAVTPAGGDTAAGRSWPEVLNALLDGRDQSADATAWAMDRIMRG
                     EATDAQIAGFVVALRAKGETVEEITGVVRAMYEHAKVIEVSGRTVDIVGTGGDGAKTVN
                     ISTMSALVVAGTGAKVVKHGNRAASSASGSSDVLEKLGVNLDLTPQRVAEVAEEAGITF
                     CFAVKFHPALRHVAAARSQLGIRTVFNALGPLTNPAKVRSQAVGVADPRLAPMIAGVLA
                     ERGNSSLVFRGDDGLDELTTTSTSRVWVVRDGKVTEESFDPRDVGIELVPVEALRGGDP
                     SYNAEVARRLLDGEKGPVRDAVLLNSAAALVALDPGPGTLAEQLGAGMAKAAESIDSGS
                     AKRVLERWVAASNA"
     misc_feature    complement(21322..21338)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
ORIGIN
        1 cgacctgatg gtgaccgcgg tggcggtcgc cgcgctgctc gccgggaccc ggcacccccg
       61 tgtgatgggc gtcctggcgg gcttcggggc gatggtcaag gtgtggccgg tgctgctgct
      121 cgtggggacc gtacggcgcc ggacgtgggc cgcggcggcg gtgaccgcgg ccgcgctggc
      181 ggtgctgttc tcgatgacca tgcccggcgc cttcaccttc ctcaccgccc agcgcggccg
      241 gggtaccgag gtggagtcgc tgggcgcact ggtcttccat gtggcgcggc acttcggctg
      301 gcacggccag gtgctgctga actacggctc ggtggagttc ctcggcccgt acgtcggcct
      361 ggtgagcacg gccgccctgg cactcaccgg cgcggccttc ggctggctgg tgctgtggcg
      421 cctgcgggcg acccggttcc cgccgcaggc actcgcggag gcggccttca cggcggtgct
      481 gatgttcacg gtgaccagcc gggtgatcag cccgcagtac ctcgtatggc tgatcggcct
      541 ggccgccgtc tgcctgtgct tccgccagag ccgcatgggc ctgcccgccc ttctcctgat
      601 gccggcggcc ttcgtcacac tcctggaatt cccgatcggc ttcgcccacg tcgtggccag
      661 cgaccggtac ggcacgaccc tcctgctcct gcgcaacggc ctgctcctca ccaccaccct
      721 cctggccgcc cacaccctgt ggcacaccac agcctccgag ccccacaccc cccaggtacc
      781 gagccagccg acccacacga acgggactcc ggtctcttcc tgagcgggag aacagctcgc
      841 tcagcccagc tgagctcgca cgtagtcctg ccactgcgtg gtgaactgct cgggcgtcgt
      901 gccgagcacc ttcctcaggg cggcctcgac cgcgcccgcg cgctttccgt gggtgccgac
      961 ggttcggtag aactcggcca ggcggagctc gccccagtgg tcggcgatca tccggcaggc
     1021 cagccagcca gtctcgtagg cctgggcgag tctggtgggg tcgctgtcga agccgaagtc
     1081 tttgtcggtg ggcagatcgg gcggtacccg gttctcctgg acggcgcggg ccagctcggg
     1141 tgcggcctcg gcgggtgtgc ggcccgtgcc gaggtagccg atccagtcgg cgtagccctc
     1201 ggacagccac agcggggtgg ccggggtggt gtccgcacgg gtcgccacat gggtcgtctc
     1261 atgggtgagc acgacctgtt tgccgacgtc gccgagaagg gcgtacgcct ccgggttgat
     1321 cacgacccgg tccgcgggcg ccctgccgga gccgcccgcc tcgcccgtgg tgaccgcggc
     1381 gatcccgcgg taggaggagg ctggtgagcc gaggacgccc gccatgccct ccagggactt
     1441 cggtacgagg accacgaccc gccgtgtcca gtgcgtgccc cacgcctggg agacggcggg
     1501 caccgcgcgg tcggcgagcc gtgcataggt gtgcagtgcg gtggccgact gcccgacccc
     1561 gaggatcagg ctgtggccgc ccttgacggc cgtcaccgcg ccctggtccc acagctgctg
     1621 ggccgccttc ttggcgggcc tgtcggcggc gacgtaccac tgcccgtcgg ccctgtggcg
     1681 gagcgtgagc gtgcggccgg tggtcaccgg ggccgtgtcg atgccgcgca gccggtagcg
     1741 gagctcggcg gcggcggtgg ccgtggagcc ggtgcggtgc aggccggtca gccggtaggt
     1801 ccaggagtcc agcgggaccg tgtggaggtt ctcgtactgc gtgcgtgagc ccgtcctgtc
     1861 gtatgccgcc tcgtcgtgcc cgaggagcgc cgccgcccgc cggtcgagca tctgctgcac
     1921 ctcggtgcgc gcggagtcgg cgcccgtccg tccgccgccg cacccggtca ggggaacgag
     1981 cagcagacag agtcccacca ctcccgagcg ccacgcccgt ctgcgaccag ccatttcccg
     2041 atcgtacggc ccgacgcgcc gggtcagacc cgggtgaccg aggagatggg catcatcccg
     2101 accgggtcgt agcgcaccgg cgcgccgggg tggggcgcgt ggatcacctg gccgttgccc
     2161 gcgtacatcg ccacatggcc ggcgtcggag cggtagacga ccaggtcacc ggggcgcacc
     2221 tgggagagcg ggatccgccg acccgcgtag cgctgctcct gcgaggtgcg cggcagctgg
     2281 accccggcgt gcgcgtacga ccactgcatc aggcccgaac agtcgaagcc ggagggtccg
     2341 ttggcgcccc agacgtaggg gcggccgagg gcggagcggg cggcggcgag ggcggcggcg
     2401 gcgcggccgg ccggggcggc ggagccggag agctccggca tgtactggcg ggcgccgcgg
     2461 gtggcccgtt cgtaggcggc gcgctccgcg tccggcaggg agttgagcag cttgcgggcc
     2521 tcggcgagct tcttctcgac ggtccgcttg tgcgaggcga cggccttacg gctccgctcc
     2581 agttcggtga gcttcccgac cgtctcggag cgctcttggg cgagttcgcg cagggccgac
     2641 tgaagctcct tgagccggcc ggcctggtgg gcgccgatcc ggtcgagcgt ggccgccttg
     2701 tcgaggtagt cctccgggtc gtcggagaag agcagggcca cggtgggatc gatgccaccc
     2761 gagcggtact gggcgccggc cagcgaaccg agctcgtccc gcatggtgtt gatgcgctcc
     2821 tgctgacggg cgatgtggtc ctgtgcgtcg ctgacctgcc tgcgcagcac gcccgcgcgt
     2881 tcgccggccc tgtcgaaggc ctcggtcgcg ttctccgcct cctggtagag gcggtccacc
     2941 tcggcgcggg ggtcgccgtg cggcgcggct gccgccggta cggcgccgag ggccgcggcg
     3001 gcggcggaca ggacgcacag gacgacggcg ccccggttga acccggacgg tacaaggcgg
     3061 cgatgggacc ccacgggaag ccgcgctcct tccgctggcg gacggctgac tgttcggaaa
     3121 ctcgccagac agtagccgcg cggacacgca gcgtccaaag tcctccagcc ggtcgcgcaa
     3181 cgcgacgacc cgccgccgac gcaggtcagc agcgggtcgt ggagtcagct cgcgttgtcg
     3241 cgaatccccc gttcgggcgg cagccgcggg gtcagacgcg gacgccgaac tggaacggca
     3301 tgttgccgat cgcctcgtag cgcacgacgg caccggtgtg cggggcgtgc agcacctggc
     3361 cgttaccggc gtagaggccg acgtggtgca ggtccccgta gaagaacacc aggtcgccga
     3421 cctggagctg gctcatggag aggcgggtgc cgatgcccgc ctgggcctgg gaggtgcgcg
     3481 ggatggagac gccggcctgg gcgtaggcgt aggaggtcag gcccgagcag tcgaaggagg
     3541 aggggccggt ggcgccgtag acgtacggct tgccgatctg ggcctgcgcg gcggagaagg
     3601 ccgcggcggc ccggccggag gcggaggtgt cgttgccgag gtccacgcgc tcggtggagg
     3661 agcggctggc gcggctctgc tcggcggcga gcgccgcctt ctccttggcc gtcagcgtgt
     3721 tgaggagcct ctgcgcctcg gcgagcttgc cctggacttc cttcttcttc ttgcccagct
     3781 cggtgcgggt ggaggcgagg tccttgagct tgtcggtggc ctctgcccgc tcctgggcga
     3841 gttcgcgctg tttgtcctga atcttcttca gggcctcgac ctgctggctg ctcaactggt
     3901 cgagcgtgga cgccttgtcg aggtagtcgt ccgggttcga ggagaggaag agctggatgg
     3961 acgggtctat gccgcccgag cggtactggg cgctggccat cgagcccagg ccgtcgcgca
     4021 gcttgttgag gtccccctga ccgcgggcga cgttgtcctg gatcgtggag atctccttct
     4081 ggagcttctc ctgcttctcc ttggccccgt tgtacttctc ggtggcctgc tccgcctgct
     4141 cgtagagctt gtcgaccttc gccttgacct cgtccttgct gagcttctcg ctcggtgccg
     4201 cgttggcggc gttcgcgctc agggcgacgg cagcggcggc tgcggtggtc agcacggtca
     4261 cgcgcgtgcg gctcggctgc ttgggtcgac ggtgggacgc cacggagacg ggctccttct
     4321 tttgagtgat cacccgtgtg gaggttcgag cccagaccct agtgaccatg ctgtgatcag
     4381 ttcaaatcct cacaccaaaa aatcctgcct cgcaaggcat tctttgcaca caactcacat
     4441 ggcgtgatcc tcggttgacg ctacgttgag cgacagaccg gtcaattcgg gcattgcata
     4501 tgcgcgttga atgttcagga cagtcgcttc agaagcaccg cagacgcgac gggtcgggca
     4561 cccgccctgg cgaccccgtc ggcgacctcg cggtcggtcg aggcgacgat gaccggacgg
     4621 cccggcggct ccgcgcgcac cagctggcgg atgagctcgt cggccgtgac acccggcttg
     4681 gagaacagca cccgcacgcc gcgcggtggg gcgagcagaa cgggcgcggc cagctcggca
     4741 ccgtcgaaga cgcaggtcac ctcggcgccg gtctgcgcgg cgagctgcga gagctggccg
     4801 agcagccgca ggcgctgctt ctccagcggc atctgcggat agccggtctt ggtgacgttg
     4861 tagccgtcga ccaccaagtg cgcctgcggc agggcgagaa gctggtcgag aatggccgga
     4921 tcgctgtccg acaaggcccg cgcggcgatg tccttcgggg tcattcgtcc cggttcgacc
     4981 gcgtccacgg tctcggccgg acggacggag acgggcggca acgccagttc ccggcgcagc
     5041 ccctgggccg cctccagcac ggtgtcgagc agcagccgta cccgcatgtc ctcgacgctg
     5101 cgcccctccc gggcggccct ccgggtcgcc tccagggcgg cctcggcctc ccccaggcgc
     5161 gccttgagcc gccgggtctc gctctcggcg gtggacacct gggcgttccc ctcggcccgt
     5221 acggcctcga tctcgccctg caccttgcgc agggccgcct cgccgcgctt gacgtcgctc
     5281 agggccgccc ggagcttgcg gtgaagcgat tccgcttcct tcttcgccgt ctccagttcg
     5341 gtacgaagcc gctcggtctc ggcccgggtc tgctcccggg cgtggtcgag ttcctcgcgc
     5401 agccgctcca gctcggcccg gctctcctcg tccgcgcgct cggcatccgc ccgctgggcc
     5461 tcctcgccgg ccgcggtgac cagcttcacc cagcccgtgg ggcgcagtac ataggccgcg
     5521 gccgccacgt cgagcgggtc cgcggccggg ggcggcgagc cggagtcgag ggcgccggcg
     5581 agttccggct gggcctctct gagcttctcg ccgatgcgct gccggaacag ggcatcggtc
     5641 tccagggccg ccgccatggc gttcccggcg aacttcgccc ggcggttcgg ggcgaaccgg
     5701 gcgtactgcc gcaactgggc gggcagttcg ccgacggtca gcccgccgaa accgtccgag
     5761 acgatctgta cgacacggcg tcgcacaccg tcgggcagcg gacggtcaag cacctcagcg
     5821 gtgccgtcgc ccggcccccc gcctgcggtc tccaccatcc gtcacacccc aatatccgta
     5881 cggggccgtc acaccccgat atccctgcgg ggccgctccc ggtcaggagt cggcgcccgg
     5941 cctgtccacc agttccacct ggtccaccgc gttgcaccag cggcagcgga ccgactcgat
     6001 ggtctcactg accacctcgc gctcctcgac cttcggctct ccggccaggt cgaggtggac
     6061 gtactcgacg accttcgagg ctcgtgtcac gtcgaagcgc gtgaggttgc cgcagaggga
     6121 gcagcgccac cgcgtcgtgg cggtaggcag gggaaccggc atcgtggctg ttctcttcct
     6181 tctagtgtcc gtgacgcgcc atctgcccga cgcgtgtggc tcgtaaccct aaggcctggt
     6241 ggtgacccgc cgctggtgcg tccacggcgg cgaggcggtc tgcgccggtg cgtcccctta
     6301 cgtcatgctc tgtgcccatg atcagcaact ggggcacggt ggcaggcagg accttcagag
     6361 cggtccgggg cacgccggcg ccgatgacgt acaccttcat cgccctgtgc tgcctgatct
     6421 tcgtgatggg gccggcgtcc gggctcaatc cggcgtacgg cacgggggac gcgctgctcg
     6481 ccgtgcagcg ggcgtacttc cggcactggg gggtcatccc cgcgaagctg ttcgaacagc
     6541 cggcgcagga agccctcact cccgccacgg ctctcttcgt gcacggcagc tgggtgcatc
     6601 tgctcggcaa catgctcttc ctctatgtct tcggggcgat gaccgaggag cggatgggcc
     6661 gcgtgcagtt caccctgttc tacgtcggct gcggctatct cgcgctgatc ggctacgcgg
     6721 ccgccaacgc ctcgtcccag cagtcgctgg tgggcgcgtc cggggcgatc tcggcggtac
     6781 tcggagcgtt cctgtacctg ttccccgatg cccgtgtcac cagtctcctc ccctttctgt
     6841 tcttcctccc gctgcgcttc ccggcctggg tcgtcctgcc cttctgggcg gccgtccagt
     6901 ggctggcggc gggccgcgcc tcccagggcc cgggcgtggc ctatctggcc catctggtgg
     6961 gcttctcgct gggcttcctg ttcgcgtggg tgcggttcgg gcgacgggtc aggggggcgg
     7021 taccggattc cggcgggggg tgagggacac cgggacacgg cgaaaggggt gtccgccgcg
     7081 acggacaccc ctcccctgac gtcttgcgct cctctcggac cgacgtcctg cgttcctctc
     7141 ggcgccccgc gtccgccgcg tcagagcccc atggacttgg cgacgatcgt gcgcatgatc
     7201 tcgctggtgc cgccgaagat ccggctcgca cggttgtcgg cgtacagccg ggcgatcgga
     7261 tggtccatcg tgaagccgag accgccgtgc agctgcaggc acttgtcgag cacccggacc
     7321 gccgtctccg tgcagtacag cttggtcgcg gccgcctcct cggcggtcag ctccccgctg
     7381 tcgaaggcgt ccagggcctg gtcgacgacc gcctgcagcg cgttcaccgt gaccttgcag
     7441 tcggcgagca cgaacttggt gttctgaaag gcggcgagcg gtttgccgaa ggcggtgcgc
     7501 tcacgcacgt actcggtggt gaggtggacc gccgcggccg cctgcgcgta cgcgccgacg
     7561 gcgatgccga ggcgttcctg cgggaagatg tcggccaggc acgcgaaggc gccgcccggc
     7621 tcgcccagca cgtcaccgac cgggacccgg acatcggtga aggtcatctg gacgatgtcg
     7681 gaggaccgca gaccgagcgt gaccggctcg gagtcgaccg tcacgcccgg tgcccgggtg
     7741 tccacggcga gcagggacat gccgccacgc cggtcggacc ggtcggcgga ggtgcggcag
     7801 gccacgagca ccagatcggc ctgggcacct ccggagacga aggccttgga gccgttgagc
     7861 aggtaatggc tgccgtcctc ggcaagctcg gcggccgtcc gcaggccggc gacgtcggag
     7921 ccggcccccg gctcggtgat cgcgatggcc gtcatcagtt cgccggtgac gaacccgggc
     7981 agccagcgcc gcttctgctc cggggtcgtg tagttcacca aggtggccgg aagcgccaga
     8041 tgcgcactgg ccccgccgaa ggtgacaccg gcccgggcgc actcctcggc gatgacggcg
     8101 ttgaacttga aactcttctc gcccgagccg ccgaactcct cggggatgcc gaacccgaag
     8161 atgccgagtt ttcccagctt gagatataag tcacgcggta cccggccggc cgtttcccat
     8221 tcggaataga cgggtacgac ctctgcctcg attaagcccc gcaccaccgc acggaacgcc
     8281 tcgtgctcgt cctggaaaac agtgcgtcgc accgctcttc cccctgtagc tctgatcggt
     8341 gtgttcgcca acgactcgac gctaatacgg agttgaggat cttgtccagg gcgccggacc
     8401 ttgtcacccg tgcttgtcat gtgcctacta ttcggtcacc gggttcacga ccgacgcgac
     8461 ggacccgcgc agtgggctgc cgattttcat gggggagaca ggcatggaac caactgacgg
     8521 taaacctttg ttcaatgctc gcgacccgcg attacgcacc gacccgtacc cgctctacaa
     8581 gcgccttcgg gacatggacc cggtccaccg gactccgtac ggtcactggg tggtgtcggg
     8641 atacaacgcg gtcgccgcac tcatacgaaa tcccaagttg agcagcgaat atccgcaaga
     8701 ccccaaatgg gccgcacaac ggggcggacg ggacagtccg atcgtgcgtg ccgcccgcag
     8761 ctggatgctg atgcgggacg gcgaggcgca ccgccggctg cgcggcctgg ccaacccgct
     8821 gttcaccgcc agggccatcc gcgagacggc cccccggatc gccggcatcg tccaccggat
     8881 catggacgac atgggcgacg gccgggacat cgacctcatc gggcagctcg cggccctggt
     8941 gccggtgacc gtcttctgcg gcctgggcgg ccttcccgtg gaggaccgtg acctgtgccg
     9001 gaagtggacc gacgcactgg gccacgtcat cgacccggcc accgacgaga ccacccgccg
     9061 ggccatgaac gacgcggccg aggagttcgg cgcctatgtc gccggacacc tggaggagcg
     9121 gcgcgcgaac ccgcgcgacg acatcatctc ccgcctgctg ctggcggagt tcgacggcga
     9181 gaagctctcc gacgaggaga tcgtcgccaa cgtcatgatg ttcttcatgg gcggtcacga
     9241 gacgaccgtc aacctcatcg gcaacggcat gctcgccctg ctgcgccacc ccgaccagct
     9301 gcgtgccctg cgcgaggacc ccggcctcgt cgagaacggc atcgacgaac tgctcaggta
     9361 cgacgcaccc atccagctgg tggcccgtat caccaccgat gacatcgagc tcgagggcac
     9421 cacgatcccg gccggctcca aggtgatgat cctgctcggc gccgccaacc gcgacccggc
     9481 ccgctacccc gaccccgacc gcctcgacct gcggcgcccg gacgtccggc cgctgtcctt
     9541 cgggggcggc ccgcactact gcatcggcgc cctgctggcg aagaccgagg cacggctcgt
     9601 cctcaccgaa ctgctgcgcc gccaccgtga catcacactc agccgcgagg acgtcgtgtg
     9661 gcgtccgcag gtcaacatcc gcgggctcag agaactccgc gtcgatctcc tctcctgacg
     9721 tcggcccggc ctcccggccg ccgggcggca tcgcccggca aatttccgca gtgtccggtt
     9781 ttctctgctt tctctacgca cgtgcccaag cgccttcgtg gatgcggagc cggttccact
     9841 ggtcctatga gcggggatga agcacagata tatgagtact cagaccattt ctccaggcat
     9901 actcgatccg agcgtcgcga ggaacgccgt ggacgccgtc ctggtggatt tcctggagag
     9961 ccggagacaa aactcgggca acccacaaat ggccaggctc gtgaaattgc tggaagaatt
    10021 catggtgggc ggcaagagaa tccggccgat gctcaccgtg atgggctgga aggcggccgg
    10081 cggagaaacc gacctgacgg ccgtggtacg cgtggcggcg tcactggaga tgttccacgc
    10141 gttcgccctc attcatgacg acatcatgga cgacagtgac acccggcgcg gccgtcccac
    10201 catccaccgg atgctcgccg gaaaacgcgg cgacgaccgt accgagcgat tcggaatcgg
    10261 cgccgcggtg ctgctgggcg acctcgcctt cgcctggtcg gaccagctgc tgcacacggc
    10321 ggacctcacc tccgcgcagt cggcggcggt actgccgctc gtcaccgaca tgcgcacgga
    10381 ggtgatgctc gggcagtacc tggacctccg cgccaccggc gagctcaccg acgacgtcga
    10441 cgccacgctc accgtcaacc gctacaagac cgccaagtac accatcgaac gcccgctgca
    10501 catcggcgcc gccctcgcgg gagccggcac ggatgccctg gccgcctgct cggcgttcgc
    10561 cctgcccctg ggcgaggcct tccagctccg cgacgacctg ctgggggtct acggcgacgt
    10621 ccgcgacacg ggcaagtcgc gcctggacga cctgcgggcc ggcaagaaca cgaccctggt
    10681 cgcgctcgcc ctgcgcgccg gcgacacggc gcagcgcgcc cggctgcgcg cactgatcgg
    10741 cgaccccggg ctggacgagg ccggcgccga ggaggtccgg gcactgttcg cgtccaccgg
    10801 cgcccgggac gccgtcgaac acatgatcga tgaccgctat cggcaggccg tccgggcgct
    10861 ggagaccgcc cccttcaccg ccgccgccgt caccgccctc aagcagctcg ccgtcacggc
    10921 caccaggagg aactcatgac cgcggacctg accgcgcccg ccaccacggc ccccgcgggc
    10981 acggcccgcc actggcagga gtgcaccgat cgcttcgccg ccctgttcga gcggcacgtc
    11041 gggtacgagg cgcggaaggt gcccatgacg gacgccgaac tgcgcgaggt catagacgcc
    11101 tgcaaccggg cggtggcccc cctgggcaag agcgtctccg acaagcgctg gatctcctac
    11161 atggacgtgg tgcgctggtc gcagagcgcc cgccacatca aggacatgga ggcgttcaag
    11221 gcggtctgcg tactcaactg cgtgaccttc gtgtgggacg acatggacgc cgccctgcac
    11281 gacttcgacc tcttcctgcc ccagctgcgc gcggtctgtg agcggtacta ctccgccgag
    11341 gacgcggagt tcgcgtacga gggggcccgc gccttcgtca ccagcgacca catgttccgc
    11401 gactccctgc tcaagaaggt gctctgcagc acctcgcccg agcagtactt ccggttccgc
    11461 gtcaccgacg tcggggtgga cttctggatg cggatgtcct acccgatcta ccgccatcgc
    11521 gagctgaccg agcactccaa gacgggcctc gccgcccgga tgaccacccg cgggctggcc
    11581 atcgtcaacg acttctactc ctacgaccgc gaacacgccc tcggccagat caccaactgc
    11641 ttccggctgt gcgacatggc cgacgacgcc ggcttccggc acttcttcca ggcccgcctc
    11701 gacgacatgg ccgaggacat ggagtgcatc aaggcgttcg acgacatcac ccgggacgtc
    11761 ctgctcgacc tgatccaggg caacttcgtg tggaccacac gggaccggcg ctaccaggcc
    11821 ccggtgaacg acgtcaactc gcgtatccag taggggccgc cggatgcgta cctccaagtc
    11881 acccgcggcg gcagggcact ggcggatcgg caccgccccc ggcgccctgc cgctcctggg
    11941 acacgtaccc gccctgtggc gccgccccct ggagttcctg gcctcactgc ccgcgtacgg
    12001 cgacctggtc gaggtccggc tcggccccgg ccgggcctac ctcgccgccc accccgagct
    12061 ggtccggcac gtgctgctca acccgcgcgt cttcgacaag ggaggagtct tcgacaaggc
    12121 acggcaactg ctcggcaaca gcctgtccgt gtcccgcggc gaggagcacc gcttccagcg
    12181 ccggctgatc cagcccgcct tccacccgac gaggatcgcc gcctacacga cggcggtggc
    12241 cgaggacacc cgggccgtga ccgacgcctg gcaggccgga aagaccctcg acatcagcga
    12301 cgccatgcac gccctgctca tgcgggtcgc cgcgcgcacc ctgttctcca ccgggctcga
    12361 cgacgccacc atcgaggagg cccggcagtg cctgcggacg gtctcgcacg gcatctacaa
    12421 gcgcacggtc gccccgctgg gcatcatgga gaagctgccc accccgggaa accgtgccta
    12481 cgaccacgcc aacgcgcggc tgcggcagat cgtggccgac atgatcgccc tgcggcggcg
    12541 gtccgacacg gaccacggcg atctgctctc caccctgctg cgggcggaac accccgagac
    12601 cggggagaag ctggacgacg gccagatcct ggaccaggtc gtcaccttcc tggtcgccgg
    12661 cagcgagacc accgcctcca ccctggcctt cgtcttccat ctcatgggca cgctgcccga
    12721 ggtggagaag cgcgtgcacg ccgaggtgga cgcggcactg gagggacgga cacccgtcta
    12781 cgacgacctg cccgcgctgc cgtacacccg caatgtcatc accgaggcgc tgcgcctgta
    12841 cccgccgtcc tggatggcga tgcgggtcac ggcgcaggac gtggaactcg gcggccggct
    12901 gatccccgcc cggacgatga tgctctacag cgcctacgcc ctgcaccaca acccggagct
    12961 cttccccgac ccggagtcct tcgatcccgg gcgctgggag ggcgaacggg ccgagcgggt
    13021 gccgcgcggg gccctgcttc cgttcggcgc gggcagccac aagtgcatcg gcgacgtcct
    13081 cgcgctcacc gagaccgcgc tgatcgtggc gaccgtcggc gcacgctggc ggctgcgccc
    13141 cgcgcccggg tcccggctgc gcccggagcc gaaggccacg ttggagtccg ggccgctgcc
    13201 gatggtgctg gaacggcgct gacccgatcc tccaccgtcc tcctttgtcc ccaccgtcct
    13261 tctccgtccc cccgtctccc tgtccgtacc gtcaccggag ggcacatccg gcatgaagac
    13321 ccaatccgac ctggccaggc gcggctggcg gatcgccaag gcgccgggcc ggcttccgct
    13381 ggtgggccac gcgctgcacc tggcgcgtcg tcccctggag ttcctggcct cgctgcccgc
    13441 cgtgggcgat ctggtcgagc tgcggctcgg caccaagccg acctacctgc cctgccatcc
    13501 ggagctggtg cagcaggtgc tgctgaacgc gcgggtctac gacaccgggg gcccggtgaa
    13561 ggagaaggcc cgccccatcc tgggcaacgg gctgatcacc tccgactggg ccgaccatcg
    13621 ccggcagcgg cgcatggtcc agccggcctt ccacacggcg cgcatcgcga cgtacgccga
    13681 ggtgatgcgc gaggagtgcg cggcgcacac ggagacctgg cgggcgggac ggcccctcga
    13741 cgtcggtgac gcgatgcagg ccctgaccgc acgggtgacg gcccgcgcgc tgttctcgac
    13801 cgagatggca ccgcactcgg tcgcggagat ccagcgcggc ctgcccgtca tggtgcgcgg
    13861 ggcgttccgt cgcgcgatgg accccaccgg tctgctggcc aggctgccgt tggccgccaa
    13921 ccgggagttc gacacggcgc tcgcccggct gcacgctctc atcgacacga tcgtcgggga
    13981 ctaccggcgc tccggcgagg accgcggcga cctgctgtcc gcgctgctgg ccgcacggga
    14041 cgaggaggac ggcggcgcga tgaccgacca ggaggtccac gaccaggtca tgacgctgct
    14101 gctggccggt gtggagacca ccgcgagcgc cctgacctgg gcctggcatc tgctggcggc
    14161 ccaccccgaa gccgaggcgc ggctgcacgc ggaggtcgac ggggtgctgg gcggccggat
    14221 cccgggctac gccgacgtgc cgaggctcgc ccagacccag cggatcttca ccgaggcact
    14281 gcggctgtac ccgccggcct ggatgtacac ccggatgacc accgaaccca ccgagttggc
    14341 cgggcaccgg ctggaagccg gttccgacct gctgatcagc ccctacgtca tccaccgcat
    14401 cccggagttc ttcccgcgcc cggaggtctt cgacccggac cggtggctgc cggagcgggc
    14461 cagggacgtc acccgaggtt cgtatctgcc gttcggcggg ggcagccgca agtgcatcgg
    14521 cgacgtcttc gggatgacgg aggcgacact ggcgctggcc accatcgcct cccggtggcg
    14581 gctgcggccg gtaccgggca ccaccgtctc gccccatgcc ggaatgagcc tgaccaccgg
    14641 accgctgccg atggcacccg aaccacgctg accggacaca gcacacgccg gcagatcagc
    14701 cgaaggtgac cggcaggtgg tgcggcccgc gcagcatcag gctggggcgc cacacgacgg
    14761 cgtcgggctc ggtgtccagg gcgagtccgg ggcaccgctc cagcagcgtg cggaaggcga
    14821 tcgcgccctg cacacgggcc agcggtgcgc ccaggcagtg gtggatgccg tagccgaacg
    14881 ccatgtggcc gcgggcgtcc cggcggatgt cgaagcggtc ggaccgggcg aaccgccggg
    14941 gatcacgcga ggcggcggcc agcacgactg ccaccgagtc cccggcgccg atcaccgtgc
    15001 cgccgatctc cacgggctcc ttggcgtagc ggaacgccgt ggtctcgacg ggtccgtcgt
    15061 agcggagcat ctcctccacg gcgttctcca gcagtgacca gtcggcgcgc agggccgcca
    15121 gctggtcggg gtggcgcagc agggcgagtg tgccgctgga cagcaggttg gccgccgtct
    15181 cgtagccggc caccagcagc aggaaggcca tgcccagcat ctcctcgaag gagagccggt
    15241 cctcctcctc gcccatgtgc ccggccagcg cgctcagcag gtcctcaccg ggttcctgcc
    15301 gcttggcggc gatgaggtcg gcaagatagc ccgtcatggc ctgggccgcg gcaccggcgg
    15361 cctcgggccg ggtgaagtcg gtgctctcca ggtaccagtc gtgaaaggtc ttgcggtcgt
    15421 tcgccggtac gccgagcagt tcgcagatga cggccagggg gaggggcagc gcgaacgcct
    15481 cgaccaggtc cgcacggccc agcggcagca tggcgtccac gagttcgtcc gcgatccgct
    15541 ggatcttggg gcgcagcgcc tcgatgcgcc ggggcgtgaa gtccttcgct accagccccc
    15601 gcagccgggt gtgctgcggg ggatccgtct gcaccatgtt caggccgatg gcgttgccgc
    15661 cgtcgtcctg ccatccggcc gagtgcctga tgtcgttgga cagccgtgcg tcggccagcg
    15721 cggatcgcgc ctcctcgtgg cccacgacga gccagaactc ccccgacgcc gaggtccgta
    15781 cccggtgcac cgggcccttg gcgcgcatgc gctcgtagac cggatacggg tcgtcgacga
    15841 attcctggcc gagtgctgac agatcttcaa agccggtcac ggacaagtga gttcctcgct
    15901 tcgaacgggc cggacacagg caaccgtgga gtactccccg gttgacggcg cgaccctaac
    15961 agcggaaacg gggagtagtc cacggttggt gttagggtgc cgcccatggc cagcggcgag
    16021 gaccggcgaa cccccaggcg cagcgacgcg cggcgcaatc gcgagacgct gatcgccgcc
    16081 gcccgggaga tctacgccga acgcggggtg gacgccccgc tggacgacat cgcccgccgg
    16141 gccgaagtcg gcaacgccac gctctaccgt cacttcgccg ggcgcgccga actgatcgag
    16201 gccgttttcc acgacgcgct caccccgatc ctggccctgg cccggcagac ccgtgagcgg
    16261 gccgacgcct ggagcggcct caccgcctac ctcgaccatg tcttcgccct cctggccgcc
    16321 gaccgcggcg cgggcgacct gatgaccacc ggcatccagg gcgtgcccac gctcgacgcc
    16381 ctgcgcgagg agaaccaccg cacgctggag acccttctgc gccgcggcca ggcgcagggc
    16441 acgatccggg ccgacctcac ggtggaggac ctgctgttcc tgctggccgc gctgggccgg
    16501 gccgcaccgg ccgcgcccgg ctcctggcgc cgccatctgg ccctgctgct ggacggcctg
    16561 cgtccggccg gcgcccaccc gctgcccgct cccccgctcg gaccggagga gttcgacgcc
    16621 gctctgcacc gtctcggcac cgccccgcgg gcacccgcgc ggcgggagcc gccccccagt
    16681 ccaccgacat cggagacctc cacaccatga cgcgtcagcg ccccatatct cccttcgaga
    16741 gcgtctactt cctggatctg ggtgccgcgg gtctcccgct gtacgacatg cccgagttcg
    16801 tcgagtccct ggtccgcggc cgcccggaca tcacgctgac gaggcgggcg ctcggcctgc
    16861 tgaccgagca ccacccgatc ctgcgctcgg aggtgacgtc cggcgaaggg ggcctgctgc
    16921 tgcgggtccg cgaccgggtc cagccgccgc tcaccgtcct cgacggcatc gaggacacct
    16981 acgccgagct gatcaactca cggcccgact ggaccgagag cctgctgcac gcctggctgc
    17041 tgaccgacgg tgagcgcagc caggtggtgc tcggcgtcca ccacggcgtg gccgacggcc
    17101 ggtcggcctt cgcccttctc gacgagttct ggcagtacta cacggccctg gcggccggcg
    17161 cggatccctc ccccgagcgg cgagaggcgc tgcccgaggc gatcgacacc cggctggccg
    17221 gcgccttccc cgacgccgag atcgacgccc tggtggacgc catcgcgcag ggcgcggcgg
    17281 ccgacgccaa acccgccacg ctgcccacgg acggcttggg acgccccgac cgtccggccg
    17341 aggcgcgccg cttcgtcgtc gaccggctgg agttcgcccc tcggaccacc gaggccgtgg
    17401 tggacgccgc ccgggcccgc ggggtgaccg tcaacagcct cgtcacaggg ctggtgatga
    17461 ccgccgtacg cgcgcaactg gcaccggagt acggtccgtt gacgatgacc tgcggtcacg
    17521 gtgtcgatct gcgcacccgg ctgaccccgc aactgcccct gagcagcgtg ctcaactgca
    17581 tcaccgggct gcagaccacg ctggccgtcc ggtacgacga ccgcccggag accgtcggcc
    17641 gggaggtggc cggccaagtc gccagctccc tggaccggcg cgaccccgag cgcttccttc
    17701 tcgccgcgct cagggcgggt gccaggggca tcgcggtgcc cgtaccggtg gtcacctacg
    17761 gcatctccaa cgtcggccgg atccccgcgc accccgtccc cgaggacatg gagctgctcc
    17821 gcttcggcgg tacggccaac gcgccgggca tgccgcccaa gatcggcgtc gcgagcttcg
    17881 gcggccggct gctcgtacag aacgagtacg acagctggac ctacggcccg gaacagatgc
    17941 ggacgctgcg cgagaccctg cgtgcctccc tgacggatct ggtcacggat agagtgaggg
    18001 ccaccccagg ccccgaggga gagaaccagc cgtgatcaca gcgatcgttc tgatcaagac
    18061 cagcgtggac cggatccccg agatcgcgga gtcgatcgct tcgctggact cggtgagcga
    18121 ggtcttctcc gtcaccggta cgtacgacct gatcgcgatg gtgcgggtca aggagcacga
    18181 ggaactggcg gaggtcatcc ccggccggat cagcaagatc ccgggggtgg aggccacgga
    18241 cacgcacgtg gccttccgca cgtactcaca gcacgacctc gaggcggcgt tctcgatcgg
    18301 gctggacaac tgaccagggc cctgatggac agatcggacg gctggacggt cacgtcgacc
    18361 caccccgtgc tcccccgtca ggagtcccgc tgacagggga gcgtgtaccg cggtgacgta
    18421 cggcggtcag accgccggga cgcagcggcc gtcctcggtg cggtactgcc acttggcgcc
    18481 gtcctggacc agttccttca cggcgttcac gaaacggtcg acgtgctcgt ccggcgtgcc
    18541 cgcgccgaag ctgacgcgga cggcgttgag ggacttctcg ccgggcgcgg cctccggagc
    18601 gccgcactcg ccctgggcct gcgggtcgcc gcccagcagg gtgcgcacga gcgggtgcgc
    18661 gcagaacagg ccgtcgcgga ccccgatgcc gtactcggcg gagagcgcgg cggcgaagtg
    18721 cgagctgttc cagccctcga cgacgaagga gatcacaccg acgcgcgggg cgtcgtcgcc
    18781 gaagagggag aggacgcgga cctgcgggac ctcggccagg cccgccctga ccttgcggat
    18841 caggtactcc tcgcgggcca ccagggtgtc gaagccggcc tcggtgaggg ccttgcaggc
    18901 ggaggcgatg gagtagacgc cgatgacgtt cggggagccg gcctcgtggc gggcggcggt
    18961 ctcgtgccag tccacggcca cgcccccgtc cgcacggcgg ctgaccccgc ggctggcgcc
    19021 gccgcccgcc aggtacggct cggccgcgcg tagccagtcg gcgcggccgg ccagcacacc
    19081 ggagccgaac ggggcgtaca gcttgtggcc ggagaaggcg acccagtcga cgtccaggtc
    19141 ctggaccgac accgggtggt gcggggccag ctgggcggcg tccaggacga tccgggcgcc
    19201 gtgcgcgtgg gcggcggcgg ccagttcgcg gaccggccac agctcgccgg tgacgttgga
    19261 ggcgcccgtg acgcacacca gggccgggcc gtgagggtcg cggtcggcga gggcccgctc
    19321 cagggtcgcg accgcctccc gcgggctgcg cggggcgtcg aggtagctga cccgggcgtc
    19381 cttccagggc agcagcgagg cgtggtgctc ggtctcgaag acgaagacct ggcagtcggc
    19441 ggggagcgcg gcggcgagca ggttgaggga gtcggtggtg gaccgggtga agatcacctg
    19501 gtcgtccgcg cggcagtcga ggaactcggc gaccgtcctg cgggcgttct cgaagaggtc
    19561 ggtggagagc tgggagaggt agccggcgcc gcggtggaca ctgccgtagt agggggcgta
    19621 ggccgccacg tcgtcccaga cgcgctggag ggcgggagcg ctggccgcgt agtcgagcgc
    19681 ggcgtaggtg acttcgccac ccgtgacgag cgggacggtg acatctccac ccagaacggg
    19741 aagaggggaa caaatggtct gggcggcggc agcggtggag acggacatgg tgaactcctg
    19801 tgagtggcaa ggcggaacca ccacgcgagc gcgcacgact cgagcgtggg gaaggtgaaa
    19861 ggggtacgcg gaagcggggc tctgcgccct atcgcattcg cttgctcaca gaaagctccc
    19921 tcgacgacca ggacccctgg tgtgcgaggg gtccgcgctt gccgtagacc tcgctgccta
    19981 cgacctggtc ctcacccggg gcaccccgcc acggacggag ggttgccgga cagtcggccg
    20041 gggcctcatg actgtcactc atgacctgga cagaaaagta ctgaagtgat cgcggtcccg
    20101 caacccgtgt ccggatcgcg ggaccgccga ccggtcatgt cacgcgttgc tggcggccac
    20161 ccaccgttcg agcacccgct tggccgagcc cgagtcgatc gactccgcgg ccttggccat
    20221 tccggcgccg agctgctcgg cgagggtgcc ggggcccgga tcgagggcca ccagggccgc
    20281 cgccgaattc agcagcacgg cgtcccgtac gggccccttc tcgccgtcca gcagccgccg
    20341 ggcgacctcc gcgttgtacg acgggtcccc gccccgcagc gcctccaccg gcaccagctc
    20401 gatgccgacg tcccgcgggt cgaagctctc ctcggtgacc ttgccgtccc ggacgaccca
    20461 gacgcgggag gtggacgtcg tggtcagctc gtcgagcccg tcgtcgccgc ggaacaccag
    20521 ggaggagttg cctcgctctg ccaggacgcc cgcgatcatc ggcgccagcc gggggtccgc
    20581 gacgccgacc gcctgggatc ggaccttggc cggatttgtc agcgggccga gagcgttgaa
    20641 gaccgtgcgg atgcccaact ggctgcgggc cgcggcgaca tggcgcagcg ccgggtggaa
    20701 cttcacggcg aagcagaagg tgatgcccgc ctcctccgcg acctcggcga cccgctgggg
    20761 cgtcaggtcg aggttgacgc cgagcttctc caggacgtcg gaggagccgg acgccgacga
    20821 ggcggcccgg ttgccgtgct tgacgacctt ggcgccggtg ccggccacca ccagcgcgga
    20881 catcgtggag atgttcaccg tcttcgcgcc gtcaccgccc gtgccgacga tgtcgaccgt
    20941 gcggccggac acctcgatca ccttggcgtg ctcgtacatc gcgcggacga cgcccgtgat
    21001 ctcctcgacg gtctcgccct tggcccgcag ggccaccacg aagccggcga tctgggcgtc
    21061 ggtcgcctcg ccgcgcatga tccggtccat cgcccaggcc gtcgcgtcgg cgctctggtc
    21121 acgtccgtcc agcagggcgt tcagcacctc gggccaggaa cggcccgccg cggtgtcgcc
    21181 tccagcgggg gtcacagcgc tcataagccg ctcctgggtg aggtcccgga ttccgggaca
    21241 cgagtctcaa cgaggtccac cctatccagc cgccgggcat ggcgaggggc cccgtccgaa
    21301 caccggacgg ggcccctgcc gtggcgtggc gtgcgcagcg atcagtggtg gccgtggccg
    21361 ctcgtgatct ccttgtactc ctcgacggtg gccttcggga tctgggagtc ctcgccgtag
    21421 agcgcgtcgc tgagcttggc gcgcagcttc tgcgtgcccg gcaccttgcg ctcgacaccg
    21481 ttctcgtcga ccgtcgggcc gatcgcggcc ggcgcgtact gctcgtgcgc cgtgagggtg
    21541 tgcagctgct cctggctgag cggctcgtgg atctcgatga actcaccgtg cggcaggcgc
    21601 ttgatgatgc cggtctcgcg accgtgcagc accttctccc tgtcccggcg ctgcaggccg
    21661 aggcagatcc gcttggtgac gatgaacgcg atgaccggtc cgacgatgaa gaagatccgg
    21721 acgaaccagg taacggcgtt gatcgacagg ctgaagtgcg tggcccacag gtcgttgcca
    21781 ccaccgacca gcgtgatcat gtacatcgtg acccaggcga cacccagagc ggtacgggtc
    21841 gggtggttgc gcg
//
