LOCUS       NZ_CP094809            21335 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Staphylococcus agnetis strain IVB6197 chromosome, complete genome.
ACCESSION   NZ_CP094809
VERSION     NZ_CP094809.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus agnetis
  ORGANISM  Staphylococcus agnetis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 2459806)
  AUTHORS   Akarsu,H., Liljander,A., Younan,M., Brodard,I., Glucks,I.,
            Labroussaa,F., Overesch,G., Kuhnert,P., Perreten,V., Drexler,J.F.,
            Corman,V.M., Falquet,L. and Jores,J.
  TITLE     Comparative Genomics of East African Camel-Associated
            Staphylococcaceae spp.: Diversity and Inheritance of Traits Involved
            in Host-Pathogen Interactions
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2459806)
  AUTHORS   Akarsu,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-2022) Institute of Veterinary Bacteriology,
            University of Bern, Langgassstrasse 122, Bern 3001, Switzerland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 328x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025560905.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 08:38:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,436
            CDSs (total)                      :: 2,354
            Genes (coding)                    :: 2,327
            CDSs (with protein)               :: 2,327
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 27
            CDSs (without protein)            :: 27
            Pseudo Genes (ambiguous residues) :: 0 of 27
            Pseudo Genes (frameshifted)       :: 11 of 27
            Pseudo Genes (incomplete)         :: 14 of 27
            Pseudo Genes (internal stop)      :: 5 of 27
            Pseudo Genes (multiple problems)  :: 3 of 27
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:07:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 291519
            Orig. end                         :: 312854
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094809.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21335
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="2"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..21335
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21335
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11335](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11335
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     gene            219..1955
                     /locus_tag="MUA95_RS01295"
                     /old_locus_tag="MUA95_01295"
     CDS             219..1955
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021352.4"
                     /locus_tag="MUA95_RS01295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01295"
                     /product="restriction endonuclease-like protein"
                     /protein_id="WP_262625625.1"
                     /transl_table=11
                     /translation="MDTHSKVAIVIGSDNNATIKPLKFFDSLQSIDFNRDISRIKEYTH
                     FKLHINGEESIKVYSDLFELYDDHKIQVDEDNRNYMGNGEIDIVDSDIANNLVPGYYLL
                     TLKEENYKYAVIEIVPKDVSNVEWKTIYQDVNNYIKGLSNSLYHKNNSSISPTVRNNNI
                     VEKIDYLEVNFTHIIFALKNIYDSPRYQVQKKYDWRPIYTQPKVDKNTLKYRSKRPDKT
                     DELYSYNKELNYNLKENIWLKKVLKFLQFELVEIKDYLNLAEEIHRGHKSSKFSSDVLI
                     ATKSLENIWTIRENINRIQHMMKMITESDWYQNIKNKRHASITHSALMDNKYNIIYKWY
                     SEFNKSSLEFVFSQKVKNCWKRTDELYEIWCFINVLELLIRNGFDPIEGWIFDDYSYND
                     LPDNTVITLNKNNIILKLHFNSIIKSERNQTTKEHPLYTGNKKNKPDIRIDIHVNDIYI
                     KSIPMDVKYRKLKNITRKEKGSLEQLLAYWAHPKSNLHLDGAKAFRRRNHRIISKVAVL
                     YPKDHSTNKRIDKLAIDHNLHFFEFSPDFKDENFTNMVNEEINEAYEIYEDIYSLEGQF
                     DA"
     gene            complement(3809..4744)
                     /locus_tag="MUA95_RS01300"
                     /old_locus_tag="MUA95_01300"
     CDS             complement(3809..4744)
                     /EC_number="1.1.1.169"
                     /GO_function="GO:0008677 - 2-dehydropantoate 2-reductase
                     activity [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019167050.1"
                     /locus_tag="MUA95_RS01300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01300"
                     /product="2-dehydropantoate 2-reductase"
                     /protein_id="WP_262618671.1"
                     /transl_table=11
                     /translation="MKQIAIAGAGAMGGRIGSQLKKAGFDVTLIDFWDEHIKAINEHGL
                     EIQTETDTHYMKIDACKPEHTEKAYDLIVILTKAMQSETMVQTLLDRGAIHENTAILTM
                     MNGLGHDERFEKIVPKSQVFLAVTMWTAGLRGPGQILLEGTGRIDLQRADGEADARTQV
                     IADMFNQANLNAYVSDNVLQTVWTKATLNSVLNPLCTILDKTIFEFGEYPEARQQIEPI
                     IEEIVAVAKAKGIVLNKETLVQKIEGAYPKETQGLHYPSMHQDLYHGRLTEVDYLNGQI
                     SKYGHELGIPTPNNDMLTHLIHQLEMTHVK"
     gene            4932..6371
                     /locus_tag="MUA95_RS01305"
                     /old_locus_tag="MUA95_01305"
     CDS             4932..6371
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002477286.1"
                     /locus_tag="MUA95_RS01305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01305"
                     /product="MDR family MFS transporter"
                     /protein_id="WP_262626535.1"
                     /transl_table=11
                     /translation="MEVGDLSEGLTTAKRNLIVTIMLLSAFVAMLNQTILNTALPAMIV
                     DLGIPETTAQWLITGFMLVNGIMIPLTAFLIDKYSTGQLYIFSMAAFLLGSVIAAMAPS
                     FAVLMIARVIQAIGAGILLPLMQFIVFMVFPVEKRGFAMGLTGIVAQSAPAIGPTLTGV
                     LIDFSSWHVPFIVVAVISLIAFGTGVFYVENLGQSKPTSLDKRSVVYSTVGFGLILYAF
                     SIVGHVGPLSPLFIISLIVGIGIVAIFTIRQCRIDAPLLSMSVLKNKTFTLSAFASMMI
                     YIGIVGPALLIPIYVQTGLGLSAFLSGLVILPGAVVNACMSTYTGKIYDRYGVRVLVIP
                     GFILLIIMTILHIFLTAETPFWYVVMIYAIRMFSVALLMMPLNTAGLNALENKEVSHGN
                     AIMNSLRIIAGAMGTAISITVLSIVSRNFMDAHGHSAKMMREATISGVDAAFIFTTVLI
                     VIGFVLSLFIRETKQSPLSQS"
     gene            6397..7626
                     /locus_tag="MUA95_RS01310"
                     /old_locus_tag="MUA95_01310"
     CDS             6397..7626
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002503250.1"
                     /locus_tag="MUA95_RS01310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01310"
                     /product="ArgE/DapE family deacylase"
                     /protein_id="WP_262626536.1"
                     /transl_table=11
                     /translation="MGVFTNEEKVQILKDVVAFKTVNDNELEVCHYFKALFQKHGIEAR
                     IDMVEGQRANLIAEIGEGSPVLGISGHMDVVAEGNHSEWTYDPFTLTEADGYLYGRGAG
                     DMKSGLVALAIAMIEIHESGALKRGRIKFMATTGEEMEQLGSKQLYENGEMDDVDALVI
                     AEPSEKMLVYAHKGSMDFRITSKGRAAHSSMPVIGQNAIKPLMQFVQHIDDEFEKISKA
                     LNCERLNFETFLDYIKPMLSENMDMDDVSRVLYGLVITNTIFNGGTQVNSVPGQASAEF
                     NVRTVPEYDNEQVKALFNYYLELMNSQGANLEQDVYLDLDPVITTGDNALVRLGVETAK
                     QHFEHDIIVSPTVGVTDASNLLRGKDEHFSFMIFGPGERAHQVDERVKKASYLNFIDYY
                     IALFTTYLSK"
     misc_feature    complement(7703..7714)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            7885..9279
                     /locus_tag="MUA95_RS01315"
                     /old_locus_tag="MUA95_01315"
     CDS             7885..9279
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017723775.1"
                     /locus_tag="MUA95_RS01315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01315"
                     /product="MFS transporter"
                     /protein_id="WP_105995326.1"
                     /transl_table=11
                     /translation="MEHNTEFEGNGRLIIGIVLGVITFWLFALSLVNVVPTLHKELGAN
                     FGLINVAVSLTSLFSGMFVVGAGGIADKYGPVKMTYVGLLLSVIGSLIIVVSPQIWPMI
                     IGRGIQGLSAAFVMPATLSIIKGYYHGRHRQAALSYWSIGSWGGGGVASFFGGITDTFL
                     GWRWIFIFSIMVAIAAMILIKGTPEVPRKASVARQKFDFAGLVLFLIFILSLNLIITQS
                     SDYGIGSPIILSLIALFIISIVIFVIMEKKRKNPLVDFEVFKDKGYTGATLSNFLMNAV
                     AGTLIVGNTFVQEDKGFTSAQAGYLSITYLVMVLITIRVGEKILQHLGAQKPMYIGSLL
                     NMVGIILISLTFLPTTAYVIACIVGYFIYGLGLGLYATPSMDTAIANANEEHIGMASGI
                     YKMSSSLGNAFGIALSTTIFAIGTSAFNMQVGAMFGLWFNVVIAFISFLLVAFLVPKSQ
                     GVQVEK"
     misc_feature    complement(7931..7946)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.16"
                     /tool="antismash"
     misc_feature    complement(9727..9742)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            9806..9937
                     /locus_tag="MUA95_RS01320"
                     /old_locus_tag="MUA95_01320"
     CDS             9806..9937
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020361779.1"
                     /locus_tag="MUA95_RS01320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01320"
                     /product="subtilosin A family bacteriocin"
                     /protein_id="WP_103346230.1"
                     /transl_table=11
                     /translation="MEQGVMVSNKGCSACAIGAACLADGPIPDFEVAGITGTFGIAS"
     CDS_motif       9806..9835
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MEQGVMVSNK"
                     /locus_tag="MUA95_RS01320_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       9836..9937
                     /prepeptide="core"
                     /locus_tag="MUA95_RS01320_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="29.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCSACAIGAACLADGPIPDFEVAGITGTFGIAS"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MEQGVMVSNK"
                     /leader_location="[9805:9835](+)"
     gene            10001..11335
                     /locus_tag="MUA95_RS01325"
                     /old_locus_tag="MUA95_01325"
     CDS             10001..11335
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020361780.1"
                     /locus_tag="MUA95_RS01325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01325"
                     /product="radical SAM protein"
                     /protein_id="WP_262618676.1"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 1.5e-28,
                     bitscore: 96.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="subtilosin (E-value: 2e-171, bitscore:
                     567.4, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.3e-41, bitscore:
                     139.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.6e-08, bitscore: 31.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5e-18, bitscore: 63.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-06, bitscore: 26.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.1e-11, bitscore:
                     39.7, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.6e-08, bitscore: 31.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRYIKFNENVRLHQLPEGGVIEMSFRDTKFDILEFEYLDLNSSA
                     FEVCTYFDGSKKIIDIIQEMCIKYDCELKDHINWYSNLIKDLYSKKLVELTQNNNTGPI
                     NLTGSKEYITPLHTTFEITHKCNLECKHCYLESSPSVKDTLSFNEFKKIADEMYNKGVL
                     TCEITGGETFVHQNAKEIIEYALNKFHKVGILTNATILREDVLDLLTKYKDKIIVGISL
                     DSVDPKVHNEFRQHPKAHQLTCKNIKRLVDRGIFVRVGMSIYEDNMWEIKEMAKLVREL
                     GAQAFAYNWIDDFGRGKSIDEVKLNKQNDISFKEFEVNVLKENKDIIPLIPINENKANN
                     CGAGWRSIVMDPNGNVRPCALFPKEFKIGNLKDSSYEEVFSSDIVNKLWKLQSPQSSSL
                     CSKECPFSDYCTGCYLKGLNTNKNHRKENCDWVIEQKLEPLMENI"
     aSDomain        10007..10282
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MUA95_RS01325_Subtilosin_rSAM_RRE.1"
                     /evalue="1.80E-30"
                     /identifier="RREFam018.1"
                     /label="MUA95_RS01325"
                     /locus_tag="MUA95_RS01325"
                     /protein_end="94"
                     /protein_start="2"
                     /score="96.2"
                     /tool="antismash"
                     /translation="RYIKFNENVRLHQLPEGGVIEMSFRDTKFDILEFEYLDLNSSAFE
                     VCTYFDGSKKIIDIIQEMCIKYDCELKDHINWYSNLIKDLYSKKLVE"
     gene            11494..12198
                     /locus_tag="MUA95_RS01330"
                     /old_locus_tag="MUA95_01330"
     CDS             11494..12198
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020364409.1"
                     /locus_tag="MUA95_RS01330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01330"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_103346228.1"
                     /transl_table=11
                     /translation="MIKISDLYVWYDKEFILENINLQLSSGEIYALIGKNGSGKTTLIN
                     TICGVLSSFKGSIVMGNTSFSAESHSKTIQSSKKERYYIADNPERIKYMNCLQYINLIL
                     DVYNTKKDHKLLQYYMERYQFSNHKNKIINDLSLGNLKKLNIICSYLINTRILIFDEPL
                     NGLDIQAIERFIEDIQLLKNKGYLIILSTHILDVIERFTNKIVLINNRKATELTFENAS
                     QIREVLGVNETT"
     gene            13425..14498
                     /locus_tag="MUA95_RS01335"
                     /old_locus_tag="MUA95_01335"
     CDS             13425..14498
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017044.4"
                     /locus_tag="MUA95_RS01335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01335"
                     /product="insulinase family protein"
                     /protein_id="WP_262618679.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 2.7e-05,
                     bitscore: 21.4, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFYIKNIKSSIYNSTMEIEILPDMDLNKLNYYQLLSYTFNELFG
                     KIDSYKYRRYTNLICYNNQFFWLHNVLSLDNNYDNCYFTNEDLNAAKEKAEKSLKEKIK
                     QYQLSPHNIHRNEYKEILSLEDIYGRYRYGKAEDFYLVDLQKKDINDVFLKNYEYKYTH
                     YNNLIKIDNPVIHKKYNLNNNFSLRNNISEVGIDNHPFYTLCWSIKTNCIEDICFYGNL
                     LQAYLSHYGHSKLFKELRIKAYQLYHFSSYFDNECNLFFIHFSSDIKEKNDIKNCVISI
                     MNNLWLSIEEFESIKTFLDTELRFLLDKQYGYNFYLFKLGQKYKKFAHPFCDIKKLNYL
                     EFNSMVKNMKFITLDEG"
     gene            14503..15459
                     /locus_tag="MUA95_RS01340"
                     /old_locus_tag="MUA95_01340"
     CDS             14503..15459
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012879.4"
                     /locus_tag="MUA95_RS01340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01340"
                     /product="insulinase family protein"
                     /protein_id="WP_262618681.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 4.9e-10, bitscore:
                     36.7, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDELDNNIMKIQFGELSGIGFHIKNSYINCISVKINFGGIDSKI
                     GYAHFLEHMKFWIGENNLYEEMKNISIVLNATTSGKSTYFTFFCVPCMTEDALNILLKY
                     LNNHDYLKKIFENEKKVVINEIKGYKSIQSQDVKLNIIRDRILGNEKDITQISLYNLHE
                     ISKKYYDRDNMSVYVVGDIKFNKDTNFSNYQNVVTKKKIITQDGECEIQGIEEVLFLKI
                     IFLNISNEKKLIYYNGGFLYYGPKQQLVKNITLYENNDTLANNIYKDILDKMSAVVRIK
                     NIVEFWNLHNNFFSNIQNICESEKLMDLINELKGELS"
     gene            15456..16082
                     /locus_tag="MUA95_RS01345"
                     /old_locus_tag="MUA95_01345"
     CDS             15456..16082
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUA95_RS01345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MUA95_01345"
                     /product="hypothetical protein"
                     /protein_id="WP_262618682.1"
                     /transl_table=11
                     /translation="MKLKYRFFIVALVVLGSYYIFGVNKYIDYWLTYFVIKNSWSEFVC
                     ISVINTLLVVPFYMYINSRIKQINHINEKFLKEKNKKDFDMEKFKKSVEIPSGNFIYKG
                     IIPIILLIGIGLKISNHFSFELPLGLIVLLYIFTFISTFYYSYSFVKNIINKRFTRYIV
                     LLIISAVVMYLLSVEEQLFLVIFSIIIYLSIRLRSIGKLTNITKI"
     gene            complement(16059..16745)
                     /locus_tag="MUA95_RS01350"
                     /old_locus_tag="MUA95_01350"
     CDS             complement(16059..16745)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024934.4"
                     /locus_tag="MUA95_RS01350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01350"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_262618684.1"
                     /transl_table=11
                     /translation="MLEFNNELFNLIKRYGECKNFKQNEIVYLNNEKNFLYAFEKGLTF
                     LKHTDITGKVLLSKICKNGSIYIETVDEYSQFQINYHLFFKENTTLYQVSINKLKEKID
                     NDDLNTLILKYSHNEIKKRELILRDYTFYNKKGMILSNLVRLANSFGKILNNGTILIDI
                     NLTHEDLSQLCGMSRERTTKTLSKLKSDNVLDYDKKSKKFILLDLDSIKNQINCEECPL
                     NFCNIC"
     gene            complement(17289..17495)
                     /locus_tag="MUA95_RS01355"
                     /old_locus_tag="MUA95_01355"
     CDS             complement(17289..17495)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012334.4"
                     /locus_tag="MUA95_RS01355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01355"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_103346400.1"
                     /transl_table=11
                     /translation="MNKHFVVTGGTSGLGLEIVRNLLHNNIKVTLLARDINKCKTLFNE
                     DGHYKIFTEKQSSKSGEHSSICL"
     misc_feature    17515..17528
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.3"
                     /tool="antismash"
     gene            complement(17565..18062)
                     /locus_tag="MUA95_RS01360"
                     /old_locus_tag="MUA95_01360"
     CDS             complement(17565..18062)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUA95_RS01360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MUA95_01360"
                     /product="hypothetical protein"
                     /protein_id="WP_262625631.1"
                     /transl_table=11
                     /translation="MNDLNKFILSGVVVLGSTLGMGHMADFNTHADAHAAQKPYYTYKG
                     YTSASSKFVLDKHFVNSFKYDNLVMNGYKITKTKQITQKEMKKDDQTFYNVSNKKANAV
                     MFALSPKTVSTKALVNVYGQPKQKPVESTQGSVYNYQIAKKTIEFFVKDGYVYAAQITT
                     MN"
     gene            complement(18133..18453)
                     /locus_tag="MUA95_RS01365"
                     /old_locus_tag="MUA95_01365"
     CDS             complement(18133..18453)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF027555.4"
                     /locus_tag="MUA95_RS01365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01365"
                     /product="DUF4889 domain-containing protein"
                     /protein_id="WP_262626537.1"
                     /transl_table=11
                     /translation="MKKLLLGIPFILILIILAYLFVSMYVLNKEEVYYGQVSNDNGLVK
                     TLVSNDSDNTKENFQLTKDGNLNVQKKDFIKIVFTDNGGVIKEQSKIKKSEVPKDLQKH
                     FQ"
     misc_feature    complement(18498..18512)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            complement(18664..20022)
                     /locus_tag="MUA95_RS01370"
                     /old_locus_tag="MUA95_01370"
     CDS             complement(18664..20022)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005283 - amino acid:sodium symporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1153: Amino acid carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017549730.1"
                     /locus_tag="MUA95_RS01370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUA95_01370"
                     /product="sodium:alanine symporter family protein"
                     /protein_id="WP_262625634.1"
                     /transl_table=11
                     /translation="MTAIKAFTEWLWGFPIVGLLLISSLFLTIYLKGVQFRHFGYMMKQ
                     TFGSINKTPRGEGTITPRQALTSALSSTVGAANIVGVPTAIMMGGPGAVFWMIVIAFLG
                     MALKFSENVLGIHYREKNAKGEFVGGPTYYMKNGFKNKKLGMIFASIFACALALEIIPS
                     VMVQGHSVASTVHDTFNVHGLITGFVIAALAALVVFGGVKRIATFTEFLVPIMVGLYLL
                     LGFIIIALNIQHFPSVVGLIIEKAFNPDAALGGSFGAALATTIRWGFARGIYSNEAGLG
                     TSPIAHAAAKTDHPVRQAFWAVSEIIVDTLIICSTTAFVVLMSGVYTASDANKKSAALT
                     SRAYEDTFGLFGSATISISMVFFVFSTIIVVMYYGSRMAEFLFGMWAGTLMKIIYTVSI
                     IIGSIGVNEILWNLLDLSLAIVLIPNIIAVILLAPQVKKLTNDFFTNYKGKRD"
     misc_feature    complement(21107..21123)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
ORIGIN
        1 taatgacata ggctttgatt ttcaactttc acaaagagtg ctctctaagg tcagaggatc
       61 acgtgaagaa ttgacggatt tagtgggaat ctatgatgcc gataatgatg aagttgtgaa
      121 ttctaaaatc attgatttga tggataagtt ttcatctatt tcagatttca cgaatgcgag
      181 aggtttaatt cgaaacaaag cgaaggaatt gaaaatcaat ggatacacat tctaaggtcg
      241 ctattgtgat tggaagcgat aataatgcaa ctataaaacc tttaaaattt tttgatagtc
      301 tacaaagtat agactttaac cgtgatattt ctcgcataaa agaatacact cattttaaat
      361 tgcacattaa tggggaggaa tcgattaagg tttattcaga tttgttcgag ttatacgatg
      421 atcataaaat tcaagttgat gaagataacc gaaattacat ggggaatggt gaaatagaca
      481 ttgtagatag cgacattgct aacaatctcg taccagggta ttatctttta acattaaaag
      541 aagagaatta taaatacgca gttatcgaga ttgttcccaa agatgtgagt aacgttgaat
      601 ggaaaacaat atatcaagac gtgaataatt atatcaaagg gttatcaaat tctttatatc
      661 ataaaaataa ttcaagtatt tctccaacag tgagaaataa caatattgtg gagaagatag
      721 actacttaga agtgaatttc actcatatta tttttgcttt gaaaaatata tatgattcac
      781 caaggtatca agttcagaaa aaatatgatt ggcgaccaat ttatacacaa cctaaagtag
      841 ataaaaacac tttaaaatat cgttcaaagc gccctgataa aacggatgag ctctactctt
      901 ataataagga gctcaattat aatctaaaag aaaatatatg gctgaaaaaa gtattgaaat
      961 ttctccaatt tgaattagtt gaaatcaaag attatttaaa tttggcggaa gaaattcatc
     1021 gtggacataa atcatctaaa tttagtagtg atgtgcttat cgcaacgaaa tcattagaaa
     1081 atatttggac tataagagaa aatatcaatc ggattcagca tatgatgaag atgattacag
     1141 agtctgattg gtatcaaaac atcaaaaata aacgacatgc ttctatcaca cattcggcat
     1201 taatggataa taaatacaat atcatttaca aatggtattc tgagttcaat aagtcatctt
     1261 tggaatttgt attttctcaa aaagtgaaaa attgctggaa aagaacagat gaactttatg
     1321 aaatatggtg ttttattaat gtattagagt tattgataag gaatggcttt gaccctattg
     1381 aaggatggat ctttgatgat tactcatata atgatttacc tgataatact gtcatcacac
     1441 tcaacaaaaa taatataatt ttgaaattgc acttcaactc gattatcaaa agtgaaagaa
     1501 atcaaactac aaaagaacat ccattatata ctggtaataa gaaaaataaa ccggatattc
     1561 gaatagatat tcatgtaaat gatatatata ttaaaagtat acctatggat gtaaaatatc
     1621 gaaaattaaa aaacataact agaaaagaaa aaggatcttt agaacaattg ttggcttatt
     1681 gggctcaccc taaatctaat ttgcatttag atggggctaa ggcgtttagg agaagaaacc
     1741 ataggattat ttcaaaagta gcggttctat atcctaaaga tcactccact aacaaacgaa
     1801 ttgataaatt ggcaattgat cataacttac attttttcga atttagtcct gattttaaag
     1861 atgaaaactt tacaaacatg gttaatgaag aaatcaatga agcttatgaa atttatgaag
     1921 atatatatag tttagaagga caatttgatg cgtaactacc aataatatga tgaagatata
     1981 tacgaataag taatgtggag acttagaaaa attttttatg gcgccaagta tacttacgaa
     2041 aattgaaaat gagcgtatta gaatacccta aattcactgt ttgatattat atgggttaaa
     2101 aaatttaaat aaatagaatt tatcacaaaa tcacagttcg gaacaaagaa tcaattaaag
     2161 ctttgttttt taagataaaa atttcgagag ttaattgaca ttattaaaac acatcaaaca
     2221 attaattctt atgacataaa acataacttt aaaattgttg aatgcatatt ataaaattaa
     2281 gtagagaaca atcatatttt tgaacttatg acttccatct gcttaaagaa aatgatatat
     2341 gctttgtaat ccatcaccgt cttcaactgt cactaatggg acgattgaag gcgtttttaa
     2401 tgttatatat ataacatcca tatgttgttc tacaccatag tgttgttagt gatggggcat
     2461 agattgatcg gtaatgattg tggtgaatgg tcgtttcaac tacttctttc atttacgtgc
     2521 ttagaaatta cgttttcaga catgattgaa ccccctcgat gacacgaggt ggtggtgtca
     2581 tacgaagggg ttagaaatga atgtgtaatc aggtaatact agggcataca acctagaatg
     2641 ggcatattgt gatataacag tactgcatct taagaggtgg ttctgctaaa acccaaaacg
     2701 gtgttatttc ttacgtctct tacactaaga atgaggttca tgtattagat tgacaggacc
     2761 tcatcagtgc ctgaagttga gtaatttcaa atgctctaag tgctgcttca aacctgggat
     2821 tgcttaattc actacaatga tatggatagg cgtgtaaaag attaacgtgt ggcgatgttt
     2881 ctgaagtttt gaatcttaac gggtgaaggt caatatgcgt gtgttcatga tatactgtga
     2941 tcaaaagtat agcgcatcaa caatagggga acgagttggc catggtctca atcatgcgtt
     3001 gaaaaacgtt ttgtatctct atagtgatta ctcaccgtaa attttgcgcg cattgagaat
     3061 gaaaaagtca tcattgcttt tcatacttaa acgataatca gacataggtg tcaaactcgg
     3121 caatcagtca tctttaatgt ttcattcgta acaccaccag ggtggatggc attgttacaa
     3181 taggttgtat gctgataaga atagatgaaa cattgatgtc gaatgtacgt gacctgctca
     3241 aaggtatggg ttaagatatt atttttaaat atgaatgagc agacatgtct acggtactcg
     3301 ataaagggca cagcccccat cgttccttaa gacactaaag ggcgattatc attacatacc
     3361 caatttagtt aataaaaggg gcacgtccgg tcataaatga agtcgcctgg tgatttgaag
     3421 ccttaaattg gaacaagatg acatatgcta agaaaatata tgttgtgtca taaattaagt
     3481 atgacaacat caaatatttt ctataacttg attataagaa gttttagtgt aaaaagcaac
     3541 ataaatttac ggaattttct taaaaattaa gtggcatata tctaaaatta agatgaaagt
     3601 gcattattct gtgcctccag aatgaagtac agcgatcatg agcctttgtg ttagaggatg
     3661 acggtacgga ctgtgtgaat taaaaataaa gtcataaaag taagcttgag aagtatcgca
     3721 taaaaagagt aacgctaaat atataaacaa acatccccgc acgctttgaa gtagtagggg
     3781 atgtttatta ttagatgcgc aagtagtgtt atttcacatg tgtcatttct aattgatgaa
     3841 ttagatgcgt taacatatcg ttgttcggag ttggtatgcc taactcatga ccatatttac
     3901 taatttggcc atttaaataa tcgacttctg ttaaacgccc atgatataag tcttggtgca
     3961 tagatggata gtgaagacct tgtgtttctt taggataagc accttcaatt ttttgaacga
     4021 gtgtttcttt atttaatacg atgccttttg ctttcgcgac agctacaatt tcttcgataa
     4081 tcggctcgat ttgttgacgt gcttctggat attctccaaa ttcaaaaatg gttttgtcta
     4141 aaattgtaca tagaggattt aatacactat ttaacgttgc tttcgtccaa acagtttgta
     4201 gtacattatc gctaacataa gcatttaagt ttgcttggtt aaacatatct gcaatgactt
     4261 gtgtacgcgc gtcggcttca ccatctgcac gttgtaaatc gatgcgccct gtaccttcta
     4321 ataaaatttg acctggaccg cgtaaacctg ctgtccacat ggttacagct aaaaatactt
     4381 gagattttgg aacaattttt tcaaaacgtt catcatgtcc aagtccattc atcattgtta
     4441 aaatagcggt attttcatga atagcaccgc gatctaatag cgtttggacc atcgtttcag
     4501 attgcattgc tttcgttaaa ataacaatta aatcatacgc tttttcagta tgttctggtt
     4561 tacatgcatc gattttcatg taatgggtat cagtttcggt ttgaatttct aatccatgtt
     4621 cattaatggc tttaatatgt tcatcccaaa agtcaatcaa tgtgacatca aagcctgctt
     4681 tttttaattg acttcctata cggccaccca tagcaccggc gcctgcaatc gcaatttgtt
     4741 tcatagtaat tcctccttag atagactgag ttgttgtata tttagcgtaa ttttaaacta
     4801 aaaagttgtc aatcttatgc gaagaaagtt accaaagttt ttataaaata ctgtggaact
     4861 agatttacat ataaatggtt tgctttgcta actataaagc gttaaaatat attttgtgaa
     4921 aataataatg aatggaggtt ggcgatttgt cagaaggttt gacgacagca aaaagaaatt
     4981 taatcgttac cattatgcta ttaagtgcat ttgtagcgat gttgaaccaa acgattttaa
     5041 atacagcgtt accagcgatg attgttgatt taggtatacc tgaaactact gcacaatggc
     5101 tgataaccgg ttttatgcta gtgaatggaa taatgattcc attgacggct tttttaattg
     5161 ataaatattc tacgggacag ctgtatattt tttcgatggc tgcgttttta ttaggctctg
     5221 tgattgcggc aatggcacca agtttcgcgg tattaatgat tgcgcgtgtc attcaagcta
     5281 tcggtgcagg tattttatta ccgctaatgc agtttatcgt atttatggtg tttcctgttg
     5341 aaaagagggg attcgcgatg gggctaacag gtattgtcgc gcagtcagct ccagcgatag
     5401 gcccaacgtt aactggtgtg ctcattgact tttcgagttg gcatgtgccg tttatcgttg
     5461 tcgctgtcat ttcactcatt gcatttggca cgggtgtatt ttatgtagaa aatttaggtc
     5521 aatctaaacc gacctcattg gataaacggt cagttgttta ttctacagtt ggatttggtt
     5581 tgatccttta tgcgttcagt attgtaggtc atgttggtcc attgtctcca ttatttatca
     5641 tcagtctcat tgtcggcatt ggtattgtgg caatatttac gatacgtcaa tgtcgtatcg
     5701 acgcaccgct tttaagtatg tcggtattaa aaaataaaac atttacacta tctgcgtttg
     5761 cttcaatgat gatttatatc ggtatcgtag gcccagcctt actcattcca atttatgttc
     5821 aaactggact tggcctctcc gcatttttat caggattggt cattttacca ggtgcggttg
     5881 tgaacgcatg tatgtcgacg tatactggta aaatttatga ccggtatggt gtccgtgtac
     5941 ttgtgattcc aggttttatt ttattaatca ttatgacaat attgcatatt ttcttaacgg
     6001 cagaaacgcc attttggtat gttgtcatga tttatgcgat tcgcatgttc tctgtggcgc
     6061 tattaatgat gccgttaaat acggcagggt taaatgcgtt agaaaataaa gaagtgtcac
     6121 atggcaatgc gattatgaat tcacttcgta ttattgccgg tgcgatggga actgcaatta
     6181 gcattactgt tctttctatc gtgtcacgaa actttatgga cgcacacggt cattcagcta
     6241 aaatgatgcg tgaagctacg attagcggtg tcgatgccgc atttattttt acgacagtat
     6301 taattgttat cggatttgtt ttatcactct ttatccgtga aacaaaacaa agcccgttat
     6361 cacaatcata agactcattt tgaaaggatg aacgttatgg gtgtttttac aaatgaagaa
     6421 aaggttcaaa ttttaaaaga tgttgtagct tttaaaacgg ttaatgataa tgaattagag
     6481 gtatgtcact attttaaagc attatttcaa aaacacggta ttgaagcgcg tattgatatg
     6541 gttgaagggc aacgcgcaaa ccttatagct gaaattggtg aaggctcccc agtacttggt
     6601 atatctggcc atatggatgt tgtagctgaa ggcaatcata gtgaatggac gtacgatcct
     6661 tttacactta cggaagcgga tggttactta tatggacgtg gcgctggaga tatgaaatct
     6721 ggacttgtcg ctttagccat agcaatgatt gaaattcatg aaagtggtgc tttaaaacgc
     6781 ggtagaatta aattcatggc gacaacaggt gaagaaatgg aacagcttgg ttcgaagcag
     6841 ttgtacgaaa atggagaaat ggatgacgtc gatgcccttg ttattgcgga accgtcagaa
     6901 aagatgttag tgtatgcgca taaaggatct atggatttcc gtatcacgtc taaaggtcgc
     6961 gctgcacaca gctcgatgcc agtgattgga caaaatgcga ttaaaccatt gatgcaattt
     7021 gttcaacata tagatgatga atttgaaaaa atttcgaaag cgttgaactg cgaacgttta
     7081 aatttcgaaa catttttgga ttacattaaa ccaatgttat ctgaaaacat ggatatggat
     7141 gatgtgtcac gcgtccttta tggtttagtt attacaaata caatatttaa tggaggcact
     7201 caagttaact ctgtacctgg acaagcgagt gcagaattca atgtgcgtac agtacctgag
     7261 tatgacaatg aacaagtcaa agcattattt aactactatt tagagctaat gaattcacag
     7321 ggtgcgaatc ttgaacaaga tgtctatctt gatttagacc ctgtcattac aacgggagat
     7381 aatgcgcttg tacgtctagg tgttgaaacc gcaaagcaac attttgagca tgatattatc
     7441 gtatcgccaa cggttggtgt tacggatgcc tcaaacttat tacggggtaa agatgaacat
     7501 ttctcattta tgatatttgg gccaggagag cgtgcgcatc aagtcgatga acgtgtgaaa
     7561 aaagcatctt atttaaactt catcgattat tatatcgcgt tatttacaac atatctttca
     7621 aaataatgat gatttaatgt gaaaagggga gcttaagttt aaatatttta acttaagttc
     7681 acctcttcta tttagcgctt ttgtaaacgc tttctattgt gcggaattgc ctctgatgct
     7741 tgtatataaa attgaaaaaa taacgcttgt agattaatat agtttgtata ttttatttat
     7801 gtagttgaag tgaatggaac tggaataacg cgttgattat tctaggcaca ttccaaatct
     7861 taactaaagg gatatgatga aatcatggaa cacaatacgg agtttgaagg aaatggacga
     7921 cttatcatag ggatcgttct aggcgtaatt acgttttggt tatttgcctt atctttagtc
     7981 aacgtcgtgc cgacattaca taaggagtta ggtgcaaatt tcggtttaat taatgtggcg
     8041 gtgagtctga cgtcactctt ttcaggtatg tttgtagtcg gggctggagg cattgcggat
     8101 aaatatggcc ctgtaaaaat gacttatgtc gggctattgt taagtgtaat tggctcactc
     8161 attattgtcg tttcaccaca aatttggcca atgattatcg ggcgtggcat tcaagggttg
     8221 tccgcagcat ttgtcatgcc ggcaacatta tctatcatta aagggtacta tcatggacgt
     8281 catcgtcaag cagcactcag ttattggtcc atcggctcat ggggtggcgg tggtgtggct
     8341 tcattttttg gaggcattac cgatacattt ttaggatggc gctggatttt tattttttca
     8401 attatggttg ccatcgcagc aatgatttta attaaaggga cgcctgaagt gccacgtaaa
     8461 gcaagtgttg cgcgtcaaaa atttgatttc gctggtttag tactattttt gatttttatt
     8521 ttaagtttaa atttaattat tacgcaaagt tcagattatg gtatcggttc acccatcatt
     8581 ttatctttaa tcgcactttt tattatttca attgtgattt ttgtcatcat ggagaaaaaa
     8641 cgtaaaaatc cattagtaga ttttgaagtg tttaaagaca agggctatac aggtgcaaca
     8701 ctttctaatt ttttaatgaa cgcggttgct ggaacattaa ttgttggtaa tacattcgtt
     8761 caagaagata aaggatttac gtcagcgcaa gcgggatacc tttcaattac ctatttagtg
     8821 atggtcttaa ttaccattcg tgtaggcgaa aagattttac aacatttagg tgcacaaaag
     8881 cccatgtata tcggcagttt actgaatatg gtcggtatca tattaatttc attgacattt
     8941 ttaccgacaa ccgcctatgt cattgcttgt atcgtaggtt attttatcta tggacttggc
     9001 ttaggcttat atgcgacacc atcgatggat actgcaattg ccaatgcgaa cgaagaacat
     9061 atcggtatgg catcaggaat ctataaaatg tcctcgtcac tcggtaacgc atttggtata
     9121 gcgttatcta caacaatctt tgcgattgga acatctgctt ttaacatgca agtgggtgcg
     9181 atgttcggac tatggttcaa tgtagttatt gcatttattt catttttact tgtggcattt
     9241 ttagtgccaa aatctcaagg tgtccaagtt gagaagtaat agaaggtgga atggttttga
     9301 aatgcttacc cacttaagta ttaaaattta attttcaaag atgtggtccg tttatcgacc
     9361 aaaacccctc gctatgtcgt tagtgagggg tttgttggtg tggatatagt ggtttataaa
     9421 ttaataatca ccttttcagt ctaatacgta aaatagcgta acaattaaga gacgtattgc
     9481 tgtggttgtg atatgatcaa ggatttcaca ctacattttt acgtaaaaag tgattactta
     9541 gaggaagtga ttctatttgt atatcccttg ctaattatta tattcgctta taataagttt
     9601 aattatgcca tgataaatga acttctatga gagtgtaata agtgataata aatacattac
     9661 tatacaatgg tattaaaatc taaaaaagta tttcgagcta tgatatttcg gaaaataata
     9721 attttatgtg actaacgtca cataaaatta taaatagata gtctaaaatt agaattggaa
     9781 gtcatacatg agaggaggaa gtgctatgga gcaaggggta atggttagca acaaaggttg
     9841 ctcggcatgc gcgattggtg ctgcttgtct agctgatggt cctattcctg actttgaggt
     9901 agcgggtatc acaggtacat tcggtatagc ttcttaattg aatatttact atgggtgtaa
     9961 cgacttgtcg ttgcactcga tttataaagg ggatctctat atgcaaaggt atataaagtt
    10021 taatgaaaat gttagattac atcaactccc agaaggcgga gtaatagaaa tgagcttcag
    10081 agatactaaa tttgatatat tagagtttga atatttagat ttgaattctt ctgcgtttga
    10141 agtatgtacc tactttgatg gtagcaaaaa gataatagat attattcaag agatgtgcat
    10201 taaatatgat tgtgaactta aggaccatat taattggtac agtaacttaa ttaaagattt
    10261 gtacagtaaa aaattagttg agctcacaca aaataataat acaggtccga ttaacttaac
    10321 aggttctaaa gagtatatca caccactgca tactactttt gaaataacgc ataaatgtaa
    10381 tttagagtgt aaacattgtt atttagaaag ctctccttct gttaaagata cactaagttt
    10441 taatgaattt aaaaaaatag ctgatgaaat gtataataaa ggtgttttaa catgtgaaat
    10501 tactggagga gaaacatttg ttcatcaaaa tgcaaaagaa ataatagagt atgcattaaa
    10561 taagtttcat aaagtaggta tattaactaa tgctactatt ttaagagaag acgtattaga
    10621 tttgcttaca aaatataagg ataagattat agttggtata tctttagata gtgttgatcc
    10681 aaaagtacat aatgaattcc gccaacatcc taaagcacat cagttaactt gtaaaaatat
    10741 taaaagacta gttgatagag gcatttttgt aagagtaggt atgtccattt acgaagataa
    10801 tatgtgggaa ataaaagaga tggctaagtt agttagagaa ttaggagcac aagcatttgc
    10861 ctacaactgg attgatgatt ttggtcgagg aaaatcaatt gatgaagtga aattaaataa
    10921 acaaaatgat atttctttca aagaattcga ggtaaatgtt ttaaaagaaa ataaagatat
    10981 catcccactt ataccgatta atgaaaataa agctaataat tgcggcgctg gatggcgatc
    11041 aatagttatg gatcctaacg gtaatgtaag accttgtgcg ttatttccga aagaatttaa
    11101 gattggtaat ttaaaagatt ctagctatga agaagtgttc tctagtgaca ttgtcaataa
    11161 attatggaaa ttacagtctc ctcaaagttc tagtttatgt tcaaaagaat gtccattcag
    11221 cgattactgt acaggatgtt atttgaaagg attaaataca aataaaaatc atcgaaaaga
    11281 gaattgtgac tgggtcatag aacaaaaact tgaacccttg atggaaaata tttaggagtg
    11341 gtaatatgtc aaaaaatttt ttgagattaa taatagttat aatttttgtg atttcaacgg
    11401 tagtgttcat attgaaaaat gattgggttt ttgccagtat ttttggaatt atctttatcg
    11461 tatttttatt aagattaata caaggtgtgt ataatgataa aaatcagtga tttatatgtt
    11521 tggtatgaca aggaatttat tttggaaaat ataaatttac aactttcgag tggagaaatt
    11581 tatgccttga ttggtaaaaa tggaagcggt aagactacac ttatcaatac aatttgtgga
    11641 gttttatcct catttaaagg aagtattgtt atgggcaata cttcctttag tgcagaaagc
    11701 cattcaaaaa caatacaaag tagtaaaaag gaaaggtatt atatagcaga taatccggaa
    11761 agaataaaat atatgaattg tttgcaatat ataaacttaa ttttagatgt atacaatacg
    11821 aaaaaagatc ataaactatt acagtattat atggaaagat accaattttc aaatcataaa
    11881 aataagataa ttaatgatct ttcacttgga aatctcaaga agctaaacat tatatgctct
    11941 tatttaataa atactaggat tttgattttt gatgaaccat taaatggatt agatattcaa
    12001 gccattgaaa ggtttataga agatatacaa ctattaaaaa ataaggggta tttaataatc
    12061 ttatctactc atattcttga tgtaattgaa aggtttacta ataaaattgt acttattaat
    12121 aatagaaaag ccacagaatt aacatttgag aatgctagtc aaattagaga ggttttgggt
    12181 gtaaatgaaa ctacataaat atctaaaata tatagttcta gctgagagta acaaatacaa
    12241 tttgaaatcg atatgtaaat tactaataag tgtattgatt ttgttgatgt ttgagttgta
    12301 tttaattttg aatagtggta ttgaaattac tatcattaaa catgcccatt ttaaattgat
    12361 tatttctttg acctcatttg ttttagcatt atcgttttgg agttctttta gaaatagtaa
    12421 tgtaaatagt atgtttaaac cattgccagt aaatataaaa aaattgtatc tatcaatggt
    12481 tgtatatatt tttttagagg tgggtctaaa gagaatgatt tttctatgga tattgcccat
    12541 atttttatat atacaattag gtattagttt gacaaccacc attatgttga tagtttcata
    12601 cgtattgaca attcttttaa cttttagttg cgtaattgtt ttttttgaaa caactgattt
    12661 gttgaaaaaa ataattttta cattcctttt attattagtg tcattatccc caatgttatt
    12721 tagctttata tttattatta taatgatagt tttaataaat gtttattttg atggtattaa
    12781 actgcttgaa aacaaaagtg ttaataaatt tttgaaaaag aatgaaaaag tatcgttatt
    12841 aaaaattgag atagaaaaat ggatttcaga taaaagtaat tggattaata gtctcatagc
    12901 agttattttt atagccataa taacatttaa tataaattct attgaaaata tagatccaaa
    12961 tattaattac tttttaatca tgataattat attagcaatg agtcctgtat acttattgtt
    13021 ttcaacagac aaaaattatc aaagactata tgtatattta cctataaata aaattaagat
    13081 atttttaatt aaatttttta tatgcatgtt tttaatgttg acgatattga caataagtct
    13141 agtaatttta tcgttaatta aacacaacct agattcaaga attgtaaaca tatatataat
    13201 catgtttatt tgtgcatttt ttagattaaa atttgatcaa aagtttccta tcttaaattg
    13261 gtcgtctaaa caggatatat ggaaaaatcc gaaaaaatat gtttctctaa tcattttaat
    13321 accatatgta tatttagcct taacttatag tatttgggtt acactccctt ttatgattgt
    13381 aatttttata ttaagtaaag ttaagtctaa taggagtgat tattttgtct ttctatatta
    13441 aaaatattaa atcttctata tataattcca ctatggaaat agaaatttta cccgatatgg
    13501 acttaaataa actgaattat tatcaattgt tatcctacac gtttaatgaa ctatttggaa
    13561 aaatagattc ctataaatat agaagataca ctaacctaat ttgttataat aatcagtttt
    13621 tctggttaca caatgtttta agtttagata ataattatga taattgttat ttcacaaatg
    13681 aagatttaaa tgcagctaaa gaaaaagcag aaaagagttt aaaagaaaag ataaagcaat
    13741 atcaattaag tcctcataac attcatagaa atgaatataa agagatcctt agtttagagg
    13801 atatatatgg aagatataga tatggaaaag cagaagattt ttatttagta gatttacaaa
    13861 agaaagatat caatgatgtc tttttgaaga attatgaata taagtatact cactataaca
    13921 atttaatcaa aatagataat cctgtaatac ataagaaata taatctcaat aataacttta
    13981 gcttaagaaa taacatttca gaagtaggaa tagataacca tcctttttac acactctgtt
    14041 ggagtattaa aaccaattgt attgaggaca tatgttttta cggaaattta ttacaagcat
    14101 atctttcgca ttatgggcat tcaaaattat ttaaagaact tagaataaag gcttaccaac
    14161 tataccattt tagttcatat tttgataatg aatgtaatct gttttttata cactttagtt
    14221 cggatattaa ggaaaaaaat gatattaaaa actgtgttat tagtataatg aataatttgt
    14281 ggttaagtat tgaagaattt gagagtatta aaactttttt agacaccgaa ttaaggtttt
    14341 tattagacaa acaatatggt tataacttct atttgtttaa gttagggcaa aaatataaaa
    14401 agtttgctca cccattttgt gacataaaaa aactaaacta tttagaattt aatagcatgg
    14461 ttaaaaatat gaaatttatc actttagatg aaggatgatc atatgctaga tgaattagat
    14521 aacaatatta tgaagattca atttggagaa cttagcggta taggttttca tataaaaaac
    14581 tcatatataa attgtatcag tgttaaaatt aattttggag ggatagatag taaaataggg
    14641 tatgctcact ttttggaaca tatgaaattt tggataggtg aaaataatct ttatgaagaa
    14701 atgaaaaata taagtattgt cttaaatgct accactagtg gaaagagtac ttattttaca
    14761 tttttctgtg ttccatgtat gacagaggat gctttaaata tacttttaaa gtatttgaac
    14821 aaccatgatt atttaaaaaa gatttttgaa aatgaaaaga aagtagttat taacgaaata
    14881 aaagggtata aaagtattca atctcaggac gttaaactta atatcataag agaccgaata
    14941 ctaggtaatg aaaaagacat cactcaaatt tcattatata atttacatga aatatcaaag
    15001 aagtattatg atagagataa tatgagtgtt tatgtcgttg gagatattaa attcaataaa
    15061 gataccaatt ttagtaatta tcaaaatgtt gtaactaaaa agaagattat tacacaggat
    15121 ggagagtgtg aaatacaagg gatcgaagaa gtgctttttt tgaaaattat ctttctaaat
    15181 atatccaatg aaaaaaaact aatatattat aatggtggat ttttatatta cggtccaaag
    15241 cagcaattag tgaaaaacat tactctatat gagaataatg acacattggc taataacatt
    15301 tataaagata ttttagataa aatgagtgca gttgttagaa taaaaaatat tgtagagttt
    15361 tggaacttgc ataataattt tttctcgaat atacaaaata tatgcgaaag tgaaaaatta
    15421 atggatttaa taaatgaact taagggtgag ttatcatgaa attaaaatac cgatttttta
    15481 ttgtagcatt ggtagtttta gggagttatt acatttttgg cgttaacaaa tatattgatt
    15541 attggttaac gtattttgtt attaaaaatt cctggtcaga atttgtatgt atatctgtaa
    15601 taaatacact tttagtcgtt ccgttttata tgtatattaa tagtaggata aagcaaatta
    15661 atcatattaa tgagaagttt ttgaaagaaa aaaacaaaaa agatttcgat atggagaaat
    15721 ttaaaaaaag tgtagaaatt cctagtggga attttattta taaaggtatc atccctataa
    15781 ttttattaat agggataggc ttaaaaattt caaatcactt ttcatttgag cttccgttag
    15841 ggcttattgt tttactgtat atattcactt ttataagtac attttattat agttatagtt
    15901 ttgttaaaaa tattattaac aaacgcttca ctaggtatat agtattactg attataagtg
    15961 cggttgttat gtatttactg tcagttgagg aacaactatt tttagtaatt ttttcaatca
    16021 taatttatct atctattcgc ttaaggtcta tagggaaatt aacaaatatt acaaaaattt
    16081 aaagggcact cttcacagtt aatttgattt ttaattgagt ctaaatctaa taggataaac
    16141 tttttgctct ttttatcata atcgagaaca ttatcgcttt ttaatttaga taaagttttg
    16201 gttgttcttt ctctactcat accacatagt tgcgaaagat cttcatgtgt taaattaata
    16261 tctattagta tggtcccatt gttgagaatt tttccaaaag aattggctaa tcgaactaga
    16321 ttagaaagaa tcattccctt tttattgtaa aaagtatagt ctctcaaaat taattctctc
    16381 tttttaattt cattatgtga atattttaaa atcaatgtat tgaggtcatc gttatcaatt
    16441 ttttccttta atttattaat tgagacttga tataaagtgg tattttcttt gaaaaataga
    16501 tggtagttta tttgaaattg actgtactca tcaaccgttt ctatgtaaat acttccattt
    16561 ttacatattt ttgataatag gactttacct gtgatgtctg tgtgctttaa aaaagttaat
    16621 cctttttcaa aggcatataa aaaattcttt tcattattta aataaacaat ttcattttgt
    16681 ttaaagtttt tacattcccc atatcttttt atgagattaa ataactcatt gttaaactct
    16741 aacatcaaga aacgtcccct ttaataagta agcttttaac ttcattactg aatctataat
    16801 attatggtat aatattatat taaaaaagtc aaaagcatac aacgatatta atttggtatg
    16861 tgttctcgta attaaaaaat tatataaaaa taaagagttt attaaaatgt ttattagagc
    16921 gatttaaaat aaagggctct attaccaagc cagaaaaaaa ctattcatta tcacatacac
    16981 attcataagt ttttagctta ctgctatata ttttaattca ctatgagaaa ttctcatttt
    17041 tatagaaaaa attgctttca attctttctt gttctaaatc cattgtaaaa tttgcatgac
    17101 taaatctttc aaaattaatc taaaaaggat tactatttac ttcattcatc attggaaggt
    17161 tggtagtcag caattgcaat catttgccat ttaatcactt acagttttaa taacttcata
    17221 ataattatgc tataaacaat ctttcgtcac cgcgtcaaag agaatttata ttctgataaa
    17281 ttcaatatct atagacagat cgagctatgt tcaccagatt tacttgattg tttctctgta
    17341 aatattttat agtgtccatc ctcattaaat aaagttttac atttattaat atctctagcg
    17401 agtagggtta cttttatatt attgtgtaat aaatttctaa caatttccaa gccaagacca
    17461 cttgttccgc cggttactac aaaatgttta ttcataatac ctccaaatga ttttatttta
    17521 tgaaaaaaga gggctttcaa atttgagccc tctgataatg cgtattaatt cattgttgtg
    17581 atttgtgcag cgtacacata accatctttt acaaaaaatt cgattgtttt cttagcaatt
    17641 tgatagttat aaactgaacc ttgtgttgat tcaacaggtt tttgtttagg ctgaccataa
    17701 acattcacta acgctttagt tgaaacagtc tttggactta acgcaaacat cacagcgttt
    17761 gcttttttat tacttacatt atagaaagtt tggtcatctt tcttcatttc tttttgagtg
    17821 atttgctttg tctttgtgat tttataaccg ttcataacta aattgtcgta tttaaagcta
    17881 tttacaaagt gtttgtcgag aacaaattta ctgctcgctg atgtataacc tttataagta
    17941 taatatggtt tttgtgcagc gtgtgcatcg gcgtgagtat tgaagtctgc catatggccc
    18001 attccaagag ttgatccaag taccacgaca ccagaaagaa tgaatttatt taagtcgttc
    18061 atattgattg ccaccttata tataattttt attaatgtta tttattttca gtacagtttt
    18121 aatacactta gattattgaa agtgtttttg taaatcttta ggaacttcag attttttgat
    18181 tttagattgt tctttaatga caccgccatt atccgtgaat acaattttga tgaaatcttt
    18241 tttttgtaca tttaaattgc catctttagt taattgaaag ttttctttgg tattatcact
    18301 atcgttagat actaaggttt taactaaacc attgtcatta cttacttgac cgtagtacac
    18361 ttcttcttta ttgaggacgt acatgcttac gaataaatat gccaaaatga ttaaaatcaa
    18421 aataaatggt atacctaata gtaacttttt catttttatt tacctccttg acaataatat
    18481 ataactttac gaatgaattg aaaccggtcc caatacctat atttgatttt aataataatt
    18541 taactatata tttctgtaat catttgatgt cgcttatcaa ttcacgtgct caatataata
    18601 gtggaatgaa tgacaaaacg aaaaagctag gagttagctc ctagctttga ttattgtatg
    18661 aagttaatca cgtttccctt tatagtttgt aaagaaatcg tttgttagtt ttttaacttg
    18721 tggtgcaagg agaatgacgg cgatgatatt tggaatcagt acaattgcta aagataaatc
    18781 tagtaaattc caaagaattt cgttcacacc aatcgaaccg atgattattg aaacggtata
    18841 gatgattttc atcagtgtgc ctgcccacat gccaaataaa aattctgcca tacgtgaacc
    18901 gtagtacatc acaacaatga ttgttgaaaa tacgaagaaa accatggaaa tagaaatggt
    18961 tgcactacca aaaaggccaa aagtatcctc ataagcgcgt gatgtaagtg cagcagattt
    19021 cttattggca tcacttgctg tgtaaacacc agacattaag acgacaaatg cagttgtcga
    19081 acaaatgatg agtgtatcaa caataatctc acttactgcc caaaacgctt gacgcacagg
    19141 atgatctgtt tttgctgcgg catgtgcaat cggtgacgtc cctaaaccag cttcattcga
    19201 atagatacct cgcgcaaaac cccaacgaat cgttgtcgca agtgcggcac caaaactacc
    19261 acctaaagcg gcatcagggt taaaagcttt ttcaataatt aaccctacaa cacttgggaa
    19321 atgttgaata tttaacgcaa taataataaa tcctaaaagt aagtaaagac ctaccataat
    19381 tggcactaaa aattcagtga atgttgcgat gcgttttaca ccgccgaata ctacaagtgc
    19441 cgctaacgca gcgataacga atccagttat taaaccgtgt acattaaacg tatcatgtac
    19501 agtgcttgct acagaatgtc cttggaccat gacacttgga ataatttcca atgctaatgc
    19561 acatgcaaaa atagatgcaa atatcatgcc taatttttta ttcttgaaac catttttcat
    19621 atagtacgtt ggaccaccaa cgaattcacc tttggcgttt ttctcacgat aatgtatacc
    19681 gagaacgttc tcgctaaatt ttagtgccat acctaaaaag gctatgacaa tcatccaaaa
    19741 gacagcgcca ggaccgccca tcataatagc agttgggacc ccaacaatgt ttgcggcacc
    19801 tactgtcgag gataacgcag aagtgagtgc ttgcctcggt gtaatggttc cttcaccgcg
    19861 tggtgtctta ttaatactgc caaaagtttg tttcatcatg taaccgaaat gacgaaattg
    19921 tacccctttt aaataaattg ttagaaataa acttgaaatc aatagcaatc ctacgatagg
    19981 aaagccccat aaccattctg tgaatgcttt aatcgcagtc atatttctcc ctctcctttg
    20041 aacttccaca tcaaatgtca ggtctctcta tgtatctcac ttaaacaaaa tattcctaat
    20101 aagtgtatcg tgacgtgatg caaaagtgta ttttttaaac cataccccta aataacgtac
    20161 atacttataa tttaaaacat attgcttaat aaattaagag ttttcggaca attcattgcg
    20221 gaaatttttt tattgtggtg acgaatgggg gataaataag ggtaaagtaa agcatcaaat
    20281 gttgattgac attggcattg agtaacaagg agatattctt agaaaatggc gttgaaatgc
    20341 gtatgatcaa gtatgaagat tgcttatgtt tagcattaaa ggattaaaag gtgataggat
    20401 agctttatgt acagaggagt taaacgaccg ctatatggat gttcagatga ctatgtgatg
    20461 cgtatgatat ggagtgtact gatgattaca gtttagcatt tgtcgtaccg ttgatacgct
    20521 gtcttatttc agcttcatgt caaatgccac gttggtttcg catgtgtaac tcccattata
    20581 aaaatagaga aatgtacatc aaaggacgtg aaaaacttgg aaaatcaaca aactaaaata
    20641 tggatagcgt ctggcgccat tactttaggg attgaattag gttctacaca cataaaaaca
    20701 gtagcggtag gaccagacta tcaaccactc gcttcagggg tttataaatg ggaaaatcaa
    20761 taccgtgatg gttattggac ctatgattta gatgatgttt ggattgggat ccaagaaagt
    20821 taccgtttaa tggcagaaca aatgaaacaa caatatgggc gtacattaag gaaaataaat
    20881 gcactcggta ttagtggcat gatgcacgga taccttgctt ttaatgaagc ggacgaattg
    20941 ctcgtgccat ttcgcacgtg gcgtaataat tatgcgaatt ttgcgagccg actcttaagt
    21001 tatcaatttc aagtcaatgt tcctgaaaga tggagtattg cccaatttga acaagccatt
    21061 atgaataaag aaccgcatgc gcatcacgtc gctaagttaa tgacacttgc gggttatgtg
    21121 cattggcagt taacgggcga acatgtcagt ggcattggag acgcatcagg aatgtttcct
    21181 atagatactg aaaaacaata ttatcgtgcg gatttaatgg accgctatga tcgtttgtta
    21241 gttgaagaag gttatgaaca aaagattgaa acaatgttac cacatatatt aaaggcgggg
    21301 gaatgtgccg gtacacttac tgaagcaggc gcaaa
//
