LOCUS       NZ_JAEDWK010000010     10846 bp    DNA     linear   CON 12-MAY-2024
DEFINITION  Stenotrophomonas maltophilia strain 13_FDSW202186518-1r-8 356, whole
            genome shotgun sequence.
ACCESSION   NZ_JAEDWK010000010
VERSION     NZ_JAEDWK010000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Stenotrophomonas maltophilia
  ORGANISM  Stenotrophomonas maltophilia
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Stenotrophomonas; Stenotrophomonas maltophilia
            group.
REFERENCE   1  (bases 1 to 1470893)
  AUTHORS   Wang,Y. and Wang,L.
  TITLE     The antimicrobial resistance, molecular epidemiology of
            Stenotrophomonas maltophilia isolated from bacteremia patients in a
            tertiary hospital in China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1470893)
  AUTHORS   Wang,Y. and Wang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2020) Department of Clinical Laboratory, Chinese
            PLA General Hospital, 28 Fuxing Road, Beijing, Beijing 100853, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.21
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 20-49x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025461895.1-RS_2024_05_12
            Annotation Date                   :: 05/12/2024 16:00:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,541
            CDSs (total)                      :: 4,460
            Genes (coding)                    :: 4,414
            CDSs (with protein)               :: 4,414
            Genes (RNA)                       :: 81
            rRNAs                             :: 3, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 46
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 12 of 46
            Pseudo Genes (incomplete)         :: 40 of 46
            Pseudo Genes (internal stop)      :: 6 of 46
            Pseudo Genes (multiple problems)  :: 10 of 46
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:09:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1064587
            Orig. end                         :: 1075433
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAEDWK010000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10846
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10846
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10846
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5846](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5846
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1502..2059
                     /locus_tag="JAK51_RS06630"
                     /old_locus_tag="JAK51_06630"
     CDS             1502..2059
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020345.4"
                     /locus_tag="JAK51_RS06630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06630"
                     /product="Mor transcription activator family protein"
                     /protein_id="WP_197619365.1"
                     /transl_table=11
                     /translation="MSSAVAFTNEGSGVMESLGGALAHALHKLNSEVDVPSVIGAAIQY
                     VAREYGGVNLCFPVSAEGAGRRSDTKARRDGFIAGLKAEVIRQLVIRGCDQDRREAAGA
                     AAVASVLTAFSGGSVYIPSMAAYRQAEQHAAIVSRYRAGERTHEIAASYGISERSVRRI
                     LQRNRERNRREGRSWKTTTDRP"
     gene            2119..2691
                     /locus_tag="JAK51_RS06635"
                     /old_locus_tag="JAK51_06635"
     CDS             2119..2691
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JAK51_RS06635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JAK51_06635"
                     /product="hypothetical protein"
                     /protein_id="WP_197619363.1"
                     /transl_table=11
                     /translation="MALRAFQIFRAGTWNSQSGSITIDKRAVTAVALNYSQAVKAAPLV
                     LGHPDVETNTFGQVRGLAEMDGELYAFADVADSLIGSVRNGSYKSVSASIYLPNSPGNP
                     MPGSYYLRHVGFLGAQAPAVKGMQPLSFAEPAHGGTPSVANFSAPIGYQVDRAQMQLYE
                     LARDVQHANPSIGFIQAAIMAQKAIQR"
     gene            2701..3495
                     /locus_tag="JAK51_RS06640"
                     /old_locus_tag="JAK51_06640"
     CDS             2701..3495
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JAK51_RS06640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JAK51_06640"
                     /product="hypothetical protein"
                     /protein_id="WP_197619361.1"
                     /transl_table=11
                     /translation="MNTITEIQSSIESLGAIKEKITAAVSERYQRLEVLAGERNRIVSQ
                     PVSRRDYTTLVWRMLDLKADHYRQRLTDELRISIFGSDGPGQMKPTVGAAMRFNTMKPD
                     DMLGTLPGRLRGAVYGGDFDRDPLSQLAATYFLLDEMKLATADALDGIAEWPKALPLKA
                     SLAKIGEIDREMLGIESELELLKKDAHRIGLTLPPKPVKVEPIQPGSWEWLNQLTESLE
                     RRRRQEAIDDPLRARSIVERDGVRGWMRMNLETGQEEFVPER"
     misc_feature    2732..2747
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.83"
                     /tool="antismash"
     gene            3932..4324
                     /locus_tag="JAK51_RS06645"
                     /old_locus_tag="JAK51_06645"
     CDS             3932..4324
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008266197.1"
                     /locus_tag="JAK51_RS06645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06645"
                     /product="hypothetical protein"
                     /protein_id="WP_049395540.1"
                     /transl_table=11
                     /translation="MNMTNSASQPPSRSLKLAASQAHDDLDTIAGALNGLRDALEVRGN
                     NDAINRDNLAMLFHATEARNLPEGVSDEGIGEARAAIIDLISPESNLNGISRARVWSLV
                     CLLAKLQEVAVHRLGEIVHGHPALDA"
     misc_feature    4380..4394
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.16"
                     /tool="antismash"
     gene            4456..4944
                     /locus_tag="JAK51_RS06650"
                     /old_locus_tag="JAK51_06650"
     CDS             4456..4944
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005412584.1"
                     /locus_tag="JAK51_RS06650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06650"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_315974155.1"
                     /transl_table=11
                     /translation="MARRYTVSTKNTPSSRLPRVGAIGIALAGGLLLAGQAAAIQPLAI
                     SAVAMSAAAEGKCGEGKCGASKATTGKPAGKARVAEGQCGEGKCGDASFARTDRDHDGK
                     VSRAEFNAVAAKRAAEFDRIDTDHDGYITEQEAHDYLRSVYTANGKPMPKGLFSRVAD"
     gene            5001..5846
                     /locus_tag="JAK51_RS06655"
                     /old_locus_tag="JAK51_06655"
     CDS             5001..5846
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014646321.1"
                     /locus_tag="JAK51_RS06655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06655"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_106467358.1"
                     /sec_met_domain="DUF692 (E-value: 2.3e-119, bitscore:
                     393.9, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLPLPSNAAGLGLRRGLIDELLAMPAGAIDFLEVAPDNWIGVGG
                     AHGAALRRLSERHPLTCHGLSLSLGGPDPLDRTLLAQTRDFLDLHQVRLYSEHLSYCAA
                     GGHVYDLLPLPFTAEAVHHVAGRITQVQDLLGRRIAVENISYYAVPGADMSEIDFINAV
                     LTEADCDLLLDVNNVFVNACNNGYDAFDFLAHVPSHRVASLHVAGHFDEDDGFKIDTHG
                     APVKGVVWALLREAYARVGVRPTLLERDFNFPPLAELLAEVAQIRQAQVEARWPEVAHG
                     "
     gene            5839..>6102
                     /locus_tag="JAK51_RS22720"
                     /pseudo=""
     CDS             5839..>6102
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021364.4"
                     /locus_tag="JAK51_RS22720"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="putative DNA-binding domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAESLATLQRRWADHVRDPAMAAPDGVEARRLAVYRRLCIDSLDT
                     LLAGTLPRLQHQLGTPRWRDTMEHYYASHTCRTPLFPQIAGEF"
     misc_feature    complement(6416..6431)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.98"
                     /tool="antismash"
     gene            6628..7266
                     /locus_tag="JAK51_RS22725"
                     /old_locus_tag="JAK51_06665"
     CDS             6628..7266
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005408497.1"
                     /locus_tag="JAK51_RS22725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06665"
                     /product="hypothetical protein"
                     /protein_id="WP_315974156.1"
                     /transl_table=11
                     /translation="MTVSNTSFLHGWRLFVAISVVLIAFALTAFALHPDAAEGSRAAIR
                     VTARTSFLLFLTVFTASSFASLLPGPFTRFLLRERRIIGLSFAFSHLLHAIAITSFGIL
                     NPAFWPARSALTNLPGTVGYIAILALAITSHRGLARRIGPTAWRRLHVTGMWIIAAVFT
                     YSYFKRVPGNFWYAVPSALLFTAFVVRWIATRVQALRRSTHARPPLRAA"
     gene            complement(7778..8914)
                     /locus_tag="JAK51_RS06665"
                     /old_locus_tag="JAK51_06670"
     CDS             complement(7778..8914)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004147841.1"
                     /locus_tag="JAK51_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06670"
                     /product="metallophosphoesterase"
                     /protein_id="WP_262228971.1"
                     /sec_met_domain="Metallophos_2 (E-value: 2.4e-09, bitscore:
                     33.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAVLSTIGFLMGLYVAWRLFWPLRMPAALKVVLSVLLVGVAVQL
                     RIVATFWGTMASPEIPKLAIATLATGSIAVLLLALVMLVLDAGLLLSRLSRWPRAVAAL
                     RARRLRPVAGVLALLVSGHGVSQGMAVPTPRQIEVSIAGLPAAFDGYRVLQLTDIHASR
                     LLTGDWVRKVVDESNALAPDLIVITGDLIDGSVEARRDDARPLADLRAPDGVVAITGNH
                     EYYAQYQAWMQAFRALHMQVLENSHLQVRRGDAALTIAGVTDPVAARYGLPLPDLGAAL
                     AGADPSAPVILLDHRPRNAREAAARGVKLQLSGHTHGGQIIGMDQLVKRANGGYVSGRY
                     DVDGMTLYVSNGAGLWAGFPARIGVPSEITLVTLRRAP"
     gene            complement(9037..10578)
                     /locus_tag="JAK51_RS06670"
                     /old_locus_tag="JAK51_06675"
     CDS             complement(9037..10578)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014036331.1"
                     /locus_tag="JAK51_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06675"
                     /product="TerC family protein"
                     /protein_id="WP_262228972.1"
                     /transl_table=11
                     /translation="MEWLADPSIWMGLATLVVLEIVLGIDNLVFIAILADKLPPHQRDR
                     ARVIGLALALLMRLVLLAALAWIMKLTEPLLTLFDHSFSGRDLILLGGGLFLLFKGTME
                     LHERLEGREHHEDGRKVYASFAMVVAQIVVLDAVFSLDSVITAVGMVDNLGVMYAAVTI
                     AMALMVVASKPLTRFVNKHPTVVVLCLGFLLMIGFSLVAEGLGYKIPKGYLYAAIAFSI
                     LVEAFNQWVRFNRERNERRQPFRQRTADAVLRMLGARPANGHDDEGVDEQVDAEERLQP
                     AEHEMIRSVLGLADRPVSSVMTVRADVQWIDLARGQEDVVARLVASPHTRLLVGDGDLD
                     SLRGVVQSRDLLADLLQGKPLQLEVNLREPQYVLSSASALQALELIRQHPVPLAVAVDE
                     YGSVEGLVTANDLLAAIAGDLVDTQDERYGVVAQGEDCWEADGALTLDDLQRLAGVSLP
                     RSADYMTISGLVLEQLGRLPDVGDAVEVTGVRVTVLAMEKRRIARLRVERLGTAP"
     gene            complement(10622..10846)
                     /locus_tag="JAK51_RS06675"
                     /old_locus_tag="JAK51_06680"
     CDS             complement(10622..10846)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012479411.1"
                     /locus_tag="JAK51_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_06680"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_106467351.1"
                     /transl_table=11
                     /translation="MAIVITLDRMLQERGMTLSELAGRIDITLANLSILKTGKARAIRF
                     STLDAICRELQCTPGDLLGYDPAQAQDAD"
ORIGIN
        1 gctgagggtg aattcaagaa cgccactgcg cgcacaaagc aagagctgtt ggacaaggca
       61 gcggagaaag acctggctga ccagcgcctt gatgctgagc ggcagctgct cggagtcagg
      121 gatcgaattg cccaattgca ggggcaaggc ccggatgcgg aactggcgaa gacccgccga
      181 gagctgaacc tactcaagca ggagttggaa cgtctgggcg aaaccgccaa agcggccgac
      241 gtcaccaaac tactcaacct gagcgaggcg agcacacgtt tcaagacgtt gcaggagacc
      301 tacaaccaga caatcggggc catcgcgctt gatcagcagc gtatccaggt tgagcttcag
      361 gcgggtctca ttactgaggc acaggctcaa gatcgcattg ttgcggtcta ccagaagaag
      421 ctcggcacca tcagggagat tgtccctgag atgcgcgaaa ttgcgttgac gctcaaggac
      481 ccggcagtca ttgcggcagt ggatcagatt gagctgaagc tccaggagat ggggcaaaca
      541 accagccttc tgcaacagtc gatccgcaac acccttgaag ggtcattcaa gaacctgttc
      601 atgtccctgg ttacgcaaac cgattcactc agtgattcga ttgccaactt cttctccagc
      661 ttggctctgg gtattgccga gttcgccgca gctcagcttg ctcaagccgc agccatgcgt
      721 cttatgagcc tgttccccgg ttcgagtggc ggtggagatg gggcgcaaga gatgaccaaa
      781 gcagcaactg ttgcggcagc agccggtgca gctattggcc ttggtgccgc gaagctggag
      841 acctctgcaa ccactctggg gtcctcggga ctcggcctgg tcatcggcgc gcaggcggtc
      901 agcaaggccg ctagccagat gcaggctgct gccgcggcta tggctgtgtc cagtgcagcc
      961 agctttgcaa ctggtggttg gaccgggcct ggtggtaagt acaaggctgc cggcatcgtg
     1021 catgccgatg aattcgtctt gcgccaggaa gtggttcgtc agtccggtgc caagacgttc
     1081 ctctcagcat tcaatcgagt gggcatggct gccatcggcg gctggcgcga cggctacgct
     1141 gagggcggcc ctgtcagcct tgggcagccc atgtcggtct cacagccaat ggcacggatg
     1201 gtggccactg ccgctcccgc gagccaggca ccgagcattg gattgcggat ggtgaatgtg
     1261 gtggagccga gcttgctggc gaactacctg gatgaccccg ggagtgacca cgtgtttatt
     1321 aacaagatca atcgcaattc ggatgcgatc cgccaggtgt tgggaggctg acgtgcaaga
     1381 tagaagctca aagacttgtg atcatccgct tctgggtggc gacgtgcctt cagacaggtg
     1441 tcagacacct gcaggcgggg gtgcagctga cgttgttcgg ggcaaaggtc aggcagcgaa
     1501 catgagcagc gcggtggctt tcacgaatga gggctcgggc gtgatggaga gcctgggtgg
     1561 cgctcttgcc catgcattgc acaagctgaa ctcagaggtg gacgttcctt cggtcattgg
     1621 agcggccata cagtacgtgg cccgtgagta tggcggggtc aatctgtgct ttccggtctc
     1681 tgccgaaggc gcgggacgcc gtagcgacac caaggctcgc cgggacgggt tcattgccgg
     1741 attgaaagcg gaggtcatcc gccaactggt aatccgtggg tgcgatcagg acagacgcga
     1801 ggcagctggt gcagcggccg tggcgtctgt gctgacggca ttctctgggg gatcggtcta
     1861 catcccatcg atggcggctt accgccaggc cgagcaacat gcggccatcg tttcccgcta
     1921 ccgagccgga gagaggactc acgaaattgc tgcgtcctac ggcatctctg agcgctcggt
     1981 ccgtcgaatt ttgcagcgaa accgcgaacg caatcgacgg gaaggtcgga gctggaaaac
     2041 tacgactgat aggccgtaac gccacgtcat cgctgcgtat gcagtcctct atttctaccc
     2101 tgtgacaggc atttcaatat ggcattgcgt gcatttcaaa tattccgagc tggaacatgg
     2161 aactctcagt ccggctcgat caccatcgac aagcgggccg tcaccgccgt tgccctcaac
     2221 tatagccagg cggtgaaggc tgcccccttg gtgctcggcc accctgatgt tgagacgaac
     2281 acctttggtc aggtgcgagg cttggctgaa atggatggcg agctctacgc ctttgccgat
     2341 gtggctgaca gcctgattgg gtcggtgcga aatggctcct acaagagcgt ctcagcttcg
     2401 atttaccttc ccaactcgcc aggcaaccca atgccgggca gctactacct ccggcatgtc
     2461 ggctttctag gtgcccaagc tcccgctgta aagggaatgc agccgttgag ctttgcagaa
     2521 cctgcgcatg gcggcactcc ctctgttgcg aacttctccg cacccatcgg gtaccaggtt
     2581 gatcgtgcgc agatgcagtt gtacgaactg gcgcgtgatg tgcaacacgc caacccatct
     2641 atcggcttta tccaagccgc gatcatggcc caaaaggcca ttcaacgata agaggtcccc
     2701 atgaacacca tcacggaaat ccagtccagc atcgaaagcc tgggcgcgat caaagagaaa
     2761 atcactgccg ccgtttctga gcgctaccag cgcttggagg tactggccgg ggaaaggaac
     2821 aggatcgtct cgcagcccgt gtcgcgcagg gactacacga cgctcgtgtg gcgtatgctg
     2881 gatttgaagg ctgatcacta tcgtcagagg ctcacggatg agctcaggat ctctatcttt
     2941 gggagcgatg gccccggcca gatgaagccc actgtagggg cggccatgcg cttcaacacg
     3001 atgaagcccg acgatatgct tggcaccctg ccggggcggc tgcgcggagc agtctacggc
     3061 ggtgattttg accgggatcc gctcagccag cttgccgcta cctacttcct cctggatgag
     3121 atgaagctgg cgaccgccga cgccctggat ggcatcgcag agtggcccaa ggccctcccg
     3181 ctaaaggctt cgctggcgaa gatcggtgag attgaccggg aaatgctcgg catcgagtcc
     3241 gagctggagt tgctgaaaaa ggatgcgcac cgcattggcc tgaccctgcc accgaagccg
     3301 gtgaaggtgg agccgatcca gccgggcagc tgggagtggt tgaaccagct gactgagagc
     3361 ttggagcgtc gtcggcgaca ggaggcgatt gacgatcccc tgcgcgctcg atcaatcgtt
     3421 gagcgggatg gcgtcagggg ctggatgcgc atgaacctgg aaaccggcca ggaagagttt
     3481 gttcccgagc gctgagccag gcgctaacgg acaagcggtg ggtgtccgtg ggccttggcc
     3541 tcaacaacga ccgcagggtg ggctgctctt tcggccgttg gccgttcgcc agattctccg
     3601 agggcgaagt cacggggcgg tgaccaccca accccccaga gctgttgcat atgcaaacct
     3661 gagggtgtag tgtctgtcac gtcgccccac atgggcggcc gggattggcg tcccgtatac
     3721 ctgaggcgca taaagcgccc atcgcccgat gaaggcgctt ttttgttgtc ccgcatcggg
     3781 cggggggctc tagtccaccg attctatggt gggcggtgcg cggggaccgc aaggtccacc
     3841 ggtcctcagg ccggcacgcc aaccgcgtac cgtccgccac cccaattggc gttgtgggct
     3901 ggcggtcact cacagacctg aggacccgac aatgaacatg accaattccg ccagccagcc
     3961 cccttcccgc tcgctcaagc tggcagcatc ccaagcccat gatgaccttg acaccattgc
     4021 cggagcgctg aatggcctgc gcgacgcact ggaagtccgg ggcaacaatg acgccatcaa
     4081 ccgggataac ctggcgatgc tcttccacgc cactgaggca cgcaacttgc cggagggggt
     4141 cagtgatgag gggattggcg aggcccgcgc tgcgatcatc gacttgatca gccccgaatc
     4201 caacttgaac ggcatctctc gcgcccgcgt gtggtcgctg gtctgcctgc tggccaagct
     4261 gcaagaggtt gctgtccacc ggctcggcga gatcgtgcac ggccatccag ctctggatgc
     4321 ttgaccgccc cattcggtcc gcagcagcct caacctgacg ccccggccat ccggggcgtt
     4381 tctgcatctg caaattcgtt acacgctacg caatctgcgg cagcatccat ttatcgcgca
     4441 ttccacgccc catttatcgc gcgccgctac accgtctcga ccaagaacac cccctcctcc
     4501 cgcctgccgc gcgtcggtgc catcggcatc gccctggccg gtggcctgct gctggccggc
     4561 caggccgcgg cgatccagcc gctggcgatc agcgcggtgg ccatgagcgc tgccgccgaa
     4621 ggcaagtgcg gtgaaggcaa gtgcggggcc agcaaggcca ccaccggcaa gcccgccggc
     4681 aaggccaggg tggccgaggg ccagtgcggc gaaggcaagt gcggcgacgc ctcgtttgcc
     4741 cgcaccgacc gtgaccacga cggcaaggtc tcgcgcgccg agttcaacgc tgtggccgcc
     4801 aagcgtgccg ccgagttcga ccgcatcgac accgaccacg acggctacat caccgagcag
     4861 gaagcgcacg actacctgcg cagcgtctac accgccaacg gcaagccgat gccgaagggc
     4921 ctgttctccc gcgttgccga ttgatcgacg ttcaaccggc gccgcctccg aggcggcgcc
     4981 ctcaccctgg agcatccgcc atgtccctgc ccctgccttc caatgccgcc ggtcttggcc
     5041 tgcgccgtgg cctgattgac gaactgctgg ccatgccggc cggtgccatc gacttcctcg
     5101 aagttgcgcc cgacaactgg atcggcgtcg gtggtgcaca cggtgcagcg ctgcgcaggt
     5161 tgagcgaacg tcaccccctg acctgccatg gcctgtcgct gtcgctgggc ggtcctgatc
     5221 cgctggaccg caccctgctg gcacagacgc gcgacttcct cgacctgcac caggtgcggt
     5281 tgtacagcga acacctgagc tactgcgccg ccggtggcca tgtctacgac ctgctgccgc
     5341 tgccgtttac cgccgaggcc gtacaccatg tcgccggtcg catcacccag gtgcaggacc
     5401 tgctgggccg acgcatcgcc gtggagaaca tctcctacta cgccgttccc ggcgcggaca
     5461 tgagcgagat cgacttcatc aacgccgtgc tcaccgaagc cgactgcgac ctgctgctgg
     5521 acgtcaataa cgtcttcgtc aacgcctgta acaacggtta cgacgccttt gatttcctgg
     5581 cccacgtgcc gtcccaccgt gtcgcctcgc tgcacgtggc gggccacttc gatgaagacg
     5641 atggcttcaa gatcgatacc cacggtgcgc cggtgaaagg tgtggtctgg gcgctgttgc
     5701 gcgaggccta tgcgcgggtg ggcgtgcgcc ccacgctgct cgaacgcgac ttcaacttcc
     5761 cgccgttggc agagttgctg gccgaggtcg cacagatccg ccaggcgcag gtcgaggcac
     5821 gttggcccga ggtggcccat ggctgagtcg ctggctaccc tgcaacggcg ctgggccgac
     5881 catgtgcgcg accctgcaat ggccgcaccc gatggcgtcg aggcgcgcag gctggcggta
     5941 taccgccgcc tgtgcatcga cagcctggac accctgctgg ctggcaccct gccacgcctg
     6001 caacaccagt tgggcacgcc gcgctggcgc gacacaatgg agcactacta tgccagccac
     6061 acctgtcgca ccccgttgtt cccacagatc gccggcgaat tcgcagcatg gctggcgatg
     6121 caggacgcgc tggcactgcc ggcctgggca gcggaactgg cgcactacga gagcacgcag
     6181 cagtcgctgc acattgaagc ccgtggcgcc gggcgtttgc tgcaccgcgt tccggtggac
     6241 agtgatgtgc tggcggtttc gccgctggtg cgggtgcttg gctaccggtg gccggtacat
     6301 gtggacgaga tgctggaacc gatgccggat gcagctccca cgctgctgct gatgcgccgc
     6361 atgcctgaat tcagtctgcg tgtcgaggaa ctggccccgc tggcctatgc ggtgctgttg
     6421 gccttcggcg atgacggcac acgtgtggat gacgtattgc agaccgtggc tgaaacacat
     6481 ggtgtcgcgc cggatgaact gcgtgcggcc tgcattccag tgctgcgcga cctctgcgcg
     6541 gcagccgttc tggttgcgtc gactgatccc cgggaacgcc ggccagcggc cggcactacc
     6601 cccctctcca ttcttcgagg cctgaccatg accgtttcca acacgtcctt cctgcacggc
     6661 tggcgcctgt tcgtagccat cagcgtggtc ctgatcgcgt tcgcactgac cgccttcgct
     6721 ctgcatcccg atgcagccga aggcagccgg gcggcgatcc gggtcactgc acgcacatcg
     6781 ttcctgctgt tcctgacggt gttcacggca tcgtcgttcg ccagcctgct gcccggcccg
     6841 ttcactcgtt tcctgctgcg cgaacggcgc atcatcggcc tgtccttcgc gttctcgcac
     6901 ctgctgcacg caatcgccat caccagtttc ggcatcctca acccggcgtt ctggccagca
     6961 cgctcagcgc tgaccaacct cccgggcacg gtgggttaca tcgccatcct ggcgctggcc
     7021 atcacctcgc accgggggct cgcccggcgc atcggaccca cggcctggcg tcgcctgcac
     7081 gtgaccggca tgtggatcat cgcagcggtg ttcacctact cgtacttcaa gcgcgtgccg
     7141 ggcaacttct ggtatgcggt gccatcggcg ctgctgttca ccgccttcgt ggtgcgctgg
     7201 atcgccacgc gggtgcaggc gctgcgccga agcacgcatg cgcggccgcc gctgcgggcg
     7261 gcctgacggg ccggggtcag atccctttgc caaaggcgaa gggatctgac cccgtgtggc
     7321 gcgataggca gcgtaggcat cgaggatctc ctgcagccgc gcgtgttgct tcgtccccat
     7381 ggctacccgt tgcacgcgct tcagcaacgt cttccacatg tatccggacc ggaagaaata
     7441 cggccgcact tcaaggaagg tcagcgcgac atccagcgta tctggatcat gttcggccag
     7501 ccgtttcagc gcgttggcgt agccgcccgg aaacgctaga cgcgcgtagt tctggtggaa
     7561 ttccgcacag gccgcagcgt gccgtgcctg ctcctccggc ccacgccaac gtgcaccagc
     7621 ggtatcgcgg atcacctggc ggagccggtt gatgtcatcg gcattggcgc ggatcaggcg
     7681 ttccatcggt gcacggggat gggccatggg tctttccaga tttgccatcg gccagatccc
     7741 ttccccaaaa gggaagggat ctgcccccac ttccgggtca cggcgcgcgg cgcagcgtca
     7801 ccagggtgat ctccgacggc acgccgatgc gcgccgggaa acccgcccag aggcctgcac
     7861 cattgctcac gtacagggtc atgccatcca cgtcgtagcg accggagaca tagccaccgt
     7921 tggcccgctt caccagctgg tccatgccga tgatctgccc gccatgggta tgcccggaca
     7981 gctgcagctt cacgccacgc gcggccgcct cacgtgcatt gcgcgggcga tggtcgagca
     8041 ggatcacggg ggcagatgga tcagcccccg ccagcgcagc acccaggtcc ggcagcggca
     8101 ggccgtagcg tgcggccacc gggtcggtaa ccccggcgat ggtcagcgcc gcatcaccgc
     8161 gccgcacctg caggtggctg ttctccagca cctgcatgtg cagcgcgcgg aacgcctgca
     8221 tccacgcctg gtactgcgcg tagtactcgt ggttgccggt gatggcaacg acgccatccg
     8281 gcgcccgtag gtccgcgagt gggcgcgcgt cgtcacggcg ggcctcgaca ctgccgtcga
     8341 tcagatcacc ggtgatcacg atcaggtccg gcgccagtgc gttgctctca tccacgacct
     8401 tgcgcaccca gtcgccggtc agcaggcggc tagcatggat gtcggtgagc tgcagcacgc
     8461 gatagccgtc gaacgcggcc ggcaatccgg cgatgctcac ctcgatctga cgtggcgtgg
     8521 gcactgccat gccctggctg acaccatgac cactgaccag cagggccagc acgccggcca
     8581 ccggtcgcag acgccgcgcg cgcaatgcgg ctaccgcgcg aggccagcgc gacagccgcg
     8641 aaagcagcag gccggcgtcc agcaccagca tcaccagcgc cagcagcaac accgcgatgg
     8701 agccggtggc cagcgtggcg atagccagct tcgggatctc gggcgaggcc atcgtgcccc
     8761 agaaggtggc gacgatgcgc agctgcacgg caacccccac cagcagcacc gacagcacga
     8821 ccttcaatgc ggcgggcatg cgcagtggcc agaacaggcg ccaggccaca tacaggccca
     8881 tcagaaaacc gatcgtactc agcactgcaa ccatcctgga aggaaaacgg gcccgccatg
     8941 gtgacggttg cgggaggtgt tgtgtagagc cgagcctgcg ctcggcttct caaaatgcag
     9001 ccgagcatgg cctcggctct acagggaacg cggcggctat ggcgccgtgc ccaggcgttc
     9061 aacccgcaga cgggcgatgc gacgtttctc cattgccagc acggtgacgc gtacaccggt
     9121 cacctccacc gcatcgccga cgtccggcag gcggcccagc tgctccagca ccaggccgga
     9181 gatggtcatg tagtcggcac tgcgcggcag cgagacgccg gccaggcgct gcaggtcgtc
     9241 cagagtcagc gcgccatcgg cctcccagca atcttcgccc tgcgcgacca cgccatagcg
     9301 ttcgtcctgg gtgtcgacca ggtcaccggc aatggccgcc agcaggtcgt tggcggtcac
     9361 caggccttcc acgctgccgt actcgtccac cgccaccgcc agcggcaccg ggtgctggcg
     9421 gatcagttcc agcgcctgca atgcgctggc actggacagc acgtactgcg gctcacgcag
     9481 attgacttcc agctgtagtg gcttgccctg cagcagatcg gccagcaggt cgcggctctg
     9541 caccacgccg cgcaggctgt ccagatcacc gtcgccgacc agcaggcggg tatgcggcga
     9601 tgccaccagg cgcgccacca cgtcctcctg cccacgtgcc aggtcgatcc attgcacgtc
     9661 ggcacgcacg gtcatcacgc tcgacaccgg ccgatcggcc aggcccagca cgctgcggat
     9721 catctcgtgt tcggccggct gcaggcgctc ttcggcgtct acctgctcgt ccacaccttc
     9781 gtcgtcgtgg ccgttggccg ggcgcgcgcc cagcatgcgc aacacggcat cggccgtgcg
     9841 ctggcggaac ggctggcggc gctcgttgcg ctcacgattg aagcgcaccc actggttgaa
     9901 ggcttcaacc aggatcgaga aggcgatcgc cgcgtacagg tagcccttcg ggatcttgta
     9961 gcccaggcct tcggccacca ggctgaaacc gatcatcaac aggaagccca ggcacagcac
    10021 gaccaccgtg ggatgcttgt tgacgaagcg ggtcagcggc ttgctggcca ccaccatcag
    10081 cgccatagca atggtcactg cggcgtacat cacgcccagg ttgtcgacca tgccaaccgc
    10141 ggtgatcacc gagtccagcg agaacaccgc gtcgagcacc acgatctgag ccaccaccat
    10201 cgcgaagctg gcatagacct tcctgccatc ctcgtgatgc tcgcggcctt ccaggcgttc
    10261 gtgcagctcc atggtgccct tgaacaacag gaacaggcca ccgcccagca ggatcaggtc
    10321 acgcccggag aagctgtggt cgaacagcgt gagcagcggt tcggtcagtt tcatgatcca
    10381 ggccagcgcg gccagcagca ccagccgcat cagcagggcc agcgccaggc cgatcacccg
    10441 cgcgcggtca cgctggtgcg gcggcagttt gtcggcaagg atcgcgatga acaccaggtt
    10501 gtcgatgccg agaacgatct ccagcacgac cagggttgca aggcccatcc atatcgaggg
    10561 gtcagccaac cattccattt caggtccgtt tcgtcagtag gcaagggaaa agagcagtca
    10621 ttcaatcggc gtcctgcgcc tgcgccgggt catacccgag caagtcgccg ggcgtgcact
    10681 gcagctcgcg gcagatcgca tcaagcgtgg aaaagcggat ggcgcgcgcc ttgccggttt
    10741 tcaggatcga caggttggcc agggtgatgt cgatgcgccc ggccagctcg gacagggtca
    10801 tgccccgttc ctgcagcatg cggtccaggg tgatgacgat cgccat
//
