LOCUS       NZ_JAEDWK010000010     10876 bp    DNA     linear   CON 12-MAY-2024
DEFINITION  Stenotrophomonas maltophilia strain 13_FDSW202186518-1r-8 356, whole
            genome shotgun sequence.
ACCESSION   NZ_JAEDWK010000010
VERSION     NZ_JAEDWK010000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Stenotrophomonas maltophilia
  ORGANISM  Stenotrophomonas maltophilia
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Stenotrophomonas; Stenotrophomonas maltophilia
            group.
REFERENCE   1  (bases 1 to 1470893)
  AUTHORS   Wang,Y. and Wang,L.
  TITLE     The antimicrobial resistance, molecular epidemiology of
            Stenotrophomonas maltophilia isolated from bacteremia patients in a
            tertiary hospital in China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1470893)
  AUTHORS   Wang,Y. and Wang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2020) Department of Clinical Laboratory, Chinese
            PLA General Hospital, 28 Fuxing Road, Beijing, Beijing 100853, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.21
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 20-49x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025461895.1-RS_2024_05_12
            Annotation Date                   :: 05/12/2024 16:00:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,541
            CDSs (total)                      :: 4,460
            Genes (coding)                    :: 4,414
            CDSs (with protein)               :: 4,414
            Genes (RNA)                       :: 81
            rRNAs                             :: 3, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 46
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 12 of 46
            Pseudo Genes (incomplete)         :: 40 of 46
            Pseudo Genes (internal stop)      :: 6 of 46
            Pseudo Genes (multiple problems)  :: 10 of 46
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:09:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 773299
            Orig. end                         :: 784175
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAEDWK010000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10876
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10876
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10876
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5876](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5876
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(212..226)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     misc_feature    463..476
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            944..1912
                     /gene="pstC"
                     /locus_tag="JAK51_RS05305"
                     /old_locus_tag="JAK51_05305"
     CDS             944..1912
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene="pstC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008572163.1"
                     /locus_tag="JAK51_RS05305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05305"
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="WP_106467557.1"
                     /transl_table=11
                     /translation="MNAIAQPVAAPSTRDTRDARNDKLFRWVLVGTVIFVLIALACAAL
                     SMLWGGRHALQMQGLSFFFSADWNPVENKFGALAPIYGTLVTALIAMVIAVPVSFGIAF
                     FLTEVAPRWLRGPVGTAIELLAGIPSIIYGMWGLFVLVPVMTEYVTPFLNETLGEWPII
                     GPLFQGPPLGIGMLTAGFVLAIMVIPFISSVMREVFLTVPTRLKESAYALGSTKWEVSW
                     DIVLPYTRSAVIGGIFLGLGRALGETMAVAFVIGNSVRLSPSLLEPGTTIAALIANDFG
                     EATETYRSALLLLGFVLFIVTFVVLAIARLMLMRLSRKEGN"
     gene            1912..2775
                     /gene="pstA"
                     /locus_tag="JAK51_RS05310"
                     /old_locus_tag="JAK51_05310"
     CDS             1912..2775
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene="pstA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005412770.1"
                     /locus_tag="JAK51_RS05310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05310"
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="WP_032127902.1"
                     /transl_table=11
                     /translation="MSTTADSLYLRRRIGNVVAITASCATALFGLFFLGWILFTLASKG
                     LAGINWDLFTKMTPPPMQEGGLANAFFGSAVMCALAIGIGTPLGVLAGTWLAEYGNARK
                     AGTVVRFVNDILLSAPSIVLGLFVYTLYVMQTGGNFSAFAGALSLAFIVLPVVVRTTDE
                     MLRLVPSQMREAALSLGIPQWKVIVQVLYRSASAGIITGILLALARISGETAPLLFTAF
                     GNQYWNNNIFQPMASVPVVMNQFAGSPYESWQVLAWAGALVLTVFVLLVSLAARGILLR
                     NRISHD"
     gene            2795..3625
                     /gene="pstB"
                     /locus_tag="JAK51_RS05315"
                     /old_locus_tag="JAK51_05315"
     CDS             2795..3625
                     /EC_number="7.3.2.1"
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene="pstB"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019237787.1"
                     /locus_tag="JAK51_RS05315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05315"
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="WP_262228836.1"
                     /transl_table=11
                     /translation="MNDLSNAVPMQRIAVPSSHESLHTPSPVKLAARGLDFYYDKFHAL
                     KGINLEIPEKRVTALIGPSGCGKSTLLRIFNRIYALYPKLEARGEVLLDGENILSPKYP
                     MNRLRSKVGMVFQKPVPFPMTIFENVAYGIRHHEKLSKADMADRVEQALRQGALWDEVK
                     DKLNQSALGLSGGQQQRLCIARAVALRPSVLLLDEPTSALDPISTSRIEQLVEELKHEY
                     TIVIVTHNMQQAARVSDYTAFMYLGDLIEHDRTEVIFSQPSQRQTEDYITGRFG"
     gene            3691..4398
                     /gene="phoU"
                     /locus_tag="JAK51_RS05320"
                     /old_locus_tag="JAK51_05320"
     CDS             3691..4398
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0051049 - regulation of transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="phoU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008265615.1"
                     /locus_tag="JAK51_RS05320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05320"
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="WP_262228837.1"
                     /transl_table=11
                     /translation="MNLPNDHIVKSYDEEQQRLVAEIVRMGEMAVAQLEASMDVIEKRD
                     ENAAHRIIANDEAIDALEQQISHDVMRLALRGPMARDLREILAGLRIPADIERIGDYAA
                     NVAKRSIALGKVPPLPQIQGLRALGRLAAQQVRRAIAAYRDNDADAALELRQDDARLDA
                     QYTALFRELLTYMMEDPRNITPCTHLLFMAKNLERVGDHATNIAENVWFLVHGEQPLPP
                     REKRDETSSTGQP"
     misc_feature    complement(3693..3713)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.67"
                     /tool="antismash"
     misc_feature    complement(3704..3719)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.97"
                     /tool="antismash"
     misc_feature    4529..4544
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     gene            4658..5014
                     /locus_tag="JAK51_RS05325"
                     /old_locus_tag="JAK51_05325"
     CDS             4658..5014
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014646537.1"
                     /locus_tag="JAK51_RS05325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05325"
                     /product="hypothetical protein"
                     /protein_id="WP_032127903.1"
                     /transl_table=11
                     /translation="MSSSNKTLSLLTATALAAGLGMTASASALSMSDLAQGYLVAGQAA
                     KASTDAKAADTKMAADATKHAEGKCGADGKSAEGKCGADKGKAAGAAAGAKAKSGDKKS
                     AEGKCGEGKCGAKH"
     gene            5001..5876
                     /locus_tag="JAK51_RS05330"
                     /old_locus_tag="JAK51_05330"
     CDS             5001..5876
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014036545.1"
                     /locus_tag="JAK51_RS05330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05330"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_262228838.1"
                     /sec_met_domain="DUF692 (E-value: 2.1e-117, bitscore:
                     387.5, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTDVRASAVHLRSPLRAAAAGLGLRRALLQDLRDAPAGDFDFL
                     ECAPENWIHVGGPAGDALAELAQRHPLSCHGLSLSLGGSAPLDTQLLEQVGQFLEKHRV
                     PLYSEHLSYCSDDGHLYDLLPIPFTDEAVRHTAARIARVQDLLGRRIAVENVSYYLAPE
                     PAMDELAFTNAVLAEADCDLLLDVNNVYVNACNHGYDADSFIAALPAERIVCLHVAGHL
                     DEAPDLKIDTHGSAVIDPVWDLLARTYARIGPRPTLLERDFNFPPYAELQGELQTIRRL
                     QATHAGVAHG"
     gene            5869..6624
                     /locus_tag="JAK51_RS05335"
                     /old_locus_tag="JAK51_05335"
     CDS             5869..6624
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019659082.1"
                     /locus_tag="JAK51_RS05335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05335"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_262228839.1"
                     /transl_table=11
                     /translation="MADTSHTLRAQQHAFTAHLRDPQAVAAPVGLEPRRVAVYQRLLFN
                     NLLGLLSNGFPVCLRLLGEPAWSDLVRYYFATHRCQTPLFTELAAEFVQWLQAQPQLPH
                     PALAELAHYEWVETALYQLPAEPLPAAGNIDPLQVPLQRSPLAWPLLYQWPVHRLGAED
                     APSQPPDEPTGLLVRREADGEVRFAVLSPLAVYLLSSIGEHPGLDGHAYLQHLAAAHGL
                     AKDALAGPGAALLQQFLQAGVIGPLAVPS"
     gene            6650..7171
                     /locus_tag="JAK51_RS05340"
                     /old_locus_tag="JAK51_05340"
     CDS             6650..7171
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014036543.1"
                     /locus_tag="JAK51_RS05340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05340"
                     /product="DoxX family protein"
                     /protein_id="WP_106467555.1"
                     /transl_table=11
                     /translation="MNTPTLANTRGQLDRLAPWLAPLGLRLLLAWEYFESGREKLHGQN
                     WFADLQDAFPFPFDQLPATLNWQLATWFELIGAVCLLVGFGTRFAAASLLVLTIVATYA
                     VHWPMEWNSLADLAMGYAITDQGFGNFKLPVLFMAMLLPLIFTGAGKLSVDAWLARRSP
                     SATPARPAVR"
     gene            7407..7991
                     /gene="rnt"
                     /locus_tag="JAK51_RS05345"
                     /old_locus_tag="JAK51_05345"
     CDS             7407..7991
                     /GO_function="GO:0016896 - RNA exonuclease activity,
                     producing 5'-phosphomonoesters [Evidence IEA]"
                     /GO_process="GO:0006364 - rRNA processing [Evidence IEA]"
                     /GO_process="GO:0042780 - tRNA 3'-end processing [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rnt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005408782.1"
                     /locus_tag="JAK51_RS05345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JAK51_05345"
                     /product="ribonuclease T"
                     /protein_id="WP_106467554.1"
                     /transl_table=11
                     /translation="MSQRFRGFLPVVVDVETGGFDSQRNALLEIAAVPIEMDENGLLYP
                     GQTASAHVVPAEGLEIDPKSLEVTGIILDHPFRLAKEEKPALDHIFTPVRAAMKKYGCQ
                     RAILVGHNAHFDLGFVNAAVARTGHKRNPFHPFSVFDTVTLAGIAYGQTVLARAATAAG
                     LGWDANEAHSAVYDTEQTARLFCTIANAWPR"
     misc_feature    complement(8174..8188)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.48"
                     /tool="antismash"
     misc_feature    complement(8634..8654)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     misc_feature    9859..9873
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.56"
                     /tool="antismash"
ORIGIN
        1 aagatcaact accagtcgat cggctccggc ggcggcatcg cccagatcaa ggccggcacc
       61 gtcgacttcg gttcctccga caagccgctg agcagcgaag agctggccca ggccggcctg
      121 gcccagttcc cgtccgccat cggcggcgtg gtcccggtgg tcaacatcga aggcctggaa
      181 gccggcaagc tgcgcctgag cggcgccctg ctggccgaca tcttcctggg caaggtcaag
      241 acctggaacg acccggccat cgtcgccgcc aacccgggcg tgaagctgcc ggaaggcaag
      301 atcaccctgg tccatcgttc ggacggttcg ggcaccacct tcaacttctc caactacctg
      361 tccaaggtca gcccggagtg gaagagcaag gtcggcgaag gcacctcggt gcagtggccg
      421 gacggcgttg gtggcaaggg caatgaaggc gtcgcttcct acgtgaagca gatcaagggc
      481 tcgatcggct acgtcgaact ggcctacgcg ctgcagaacg gcatgccgta caccgccatg
      541 cagaacgcag ccggcaactg ggtcgagccg agcgcggaaa ccttcgccgc tgcggccgcc
      601 agcgccgact gggccagcgc caaggacttc aacctggtca tcaccaacgc cccgggcgag
      661 caggcgtggc cgatcaccgc caccaacttc atgctgatgc agaagcagcc gaaggacgcc
      721 aagcgcaacc aggacaccct ggccttcttc aagtgggcct tcgagaacgg ccaggcccag
      781 gccaacgagc tgcactacgt gccgctgccg gccgaactgg tcaagcagat cgaggcctac
      841 tgggcgaccg acctgaagtg atggacacga cggtgcccgc cccgcgcggg caccgcctct
      901 tccacgccgt gccgccccgc cccttcctgg ccctgccgtc cccatgaatg ccatcgccca
      961 gcctgtagca gccccgtcca cgcgtgatac gcgtgatgcc cgcaacgaca aactgttccg
     1021 atgggtgctg gtcggcaccg tcatcttcgt cctgatcgcc ctggcctgcg ccgcgctgtc
     1081 gatgctgtgg ggcggccgtc atgccctgca gatgcagggc ctgagcttct ttttctccgc
     1141 cgactggaat ccggtcgaaa acaaattcgg cgccctcgct ccgatctacg gcaccctggt
     1201 caccgcgctc atcgcgatgg tcatcgccgt gccggtcagc ttcggcatcg ccttcttcct
     1261 caccgaagtc gcgccgcgct ggctgcgtgg cccggttggt accgccatcg aactgctggc
     1321 cggcatcccc tcgatcatct acggcatgtg gggcctgttc gtgctggtgc cggtgatgac
     1381 cgagtacgtc accccgttcc tcaacgaaac cctgggcgag tggccgatca tcggcccgct
     1441 gttccagggt ccgccgctgg gcatcggcat gctcaccgcc ggtttcgtgc tggccatcat
     1501 ggtcattccg ttcatctctt cggtgatgcg cgaagtgttc ctgaccgtac cgacccgcct
     1561 gaaggaatcg gcctacgcgc tcggctccac caagtgggaa gtgagctggg acatcgtcct
     1621 gccctacacc cgttctgcgg tgatcggcgg catcttcctc ggccttggcc gcgccctggg
     1681 cgagacgatg gcggtggcct tcgtgatcgg caacagcgtg cgcctgtcgc cgtcgctgct
     1741 ggaaccgggc accaccatcg ccgcgctgat cgccaacgat ttcggcgaag ccactgaaac
     1801 ctaccgctcg gccctgctgc tgctcggctt cgtcctcttc atcgtcacct tcgtggtgct
     1861 ggccatcgcc cgcctgatgc tgatgcgctt gtcccgcaag gagggcaact gatgtccacc
     1921 accgctgatt cgctgtacct gcgccgtcgc atcggcaacg tcgttgcgat caccgcctcc
     1981 tgcgccaccg ccctgttcgg cctgttcttc ctgggctgga tcctgttcac ccttgcttcc
     2041 aagggcctgg ccggcatcaa ctgggatctg ttcaccaaga tgacgccgcc gccgatgcag
     2101 gaaggcggcc ttgccaacgc cttcttcggt agcgcggtga tgtgtgcgct ggcgatcggc
     2161 atcggcacgc cgctgggcgt gctggccggc acctggctgg ccgagtacgg caacgcccgc
     2221 aaggccggca ccgtggtccg cttcgtcaac gacatcctgc tgtcggcccc atcgatcgtg
     2281 ctcggcctgt tcgtctacac gctgtacgtg atgcagaccg gcggcaactt ctcggcattc
     2341 gccggtgcgc tgtcgctggc cttcatcgtg ctgccggtgg tggtgcgcac caccgacgag
     2401 atgctgcgcc tggtgccctc gcagatgcgc gaagcggccc tgtcgctggg catcccgcag
     2461 tggaaggtga tcgtgcaggt gctgtaccgc agtgcctcgg ccggcatcat caccggcatc
     2521 ctgctggcgt tggcccgcat ctccggcgag accgcgccgc tgctgttcac tgccttcggc
     2581 aaccagtact ggaacaacaa catcttccag ccgatggcct cggtgccggt ggtgatgaac
     2641 cagttcgctg gcagtccgta tgaatcctgg caggtgctgg cctgggccgg tgccctggtg
     2701 ctgactgtct tcgtgttgct ggtcagcctt gccgcccgcg gcatcctgct gcgcaaccgt
     2761 atctcccatg actgaccttt ccgtggataa cgccatgaac gacctttcca acgccgtgcc
     2821 gatgcagcgc atcgccgtgc cgtcctcgca cgagagcctg cacacgccgt cgccggtgaa
     2881 gctggctgcg cgtggactgg acttctacta cgacaagttc cacgccctga agggcatcaa
     2941 cctggagatt ccggaaaagc gcgtgaccgc gctgatcggt ccctccggct gcggcaagtc
     3001 gaccctgctg cgcatcttca accgcatcta cgcgctgtac ccgaagctgg aagcgcgcgg
     3061 tgaagtgctg ctggacggcg agaacatcct gtcgccgaag tacccgatga accgcctgcg
     3121 cagcaaggtc ggcatggtgt tccagaagcc ggtgccgttc ccgatgacca tcttcgagaa
     3181 cgtggcctac ggcatccgcc accacgaaaa gctgagcaag gccgacatgg ccgaccgcgt
     3241 ggaacaggcc ctgcgccagg gcgcgctgtg ggacgaagtg aaggacaagc tgaaccagag
     3301 cgcgctgggc ctgtccggcg gccagcagca gcgtctgtgc atcgcccgtg ccgtggccct
     3361 gcgcccgtcg gtgctgctgc tggacgaacc gacctcggcg ctggacccga tctccaccag
     3421 ccgcatcgaa cagctggtgg aagaactcaa gcacgagtac accatcgtga tcgtcaccca
     3481 caacatgcag caggccgcgc gcgtgtccga ctacaccgcc ttcatgtacc tgggcgacct
     3541 gatcgaacac gaccgcaccg aagtgatctt ctcgcagccg tcgcaacggc agaccgagga
     3601 ttacatcacc ggtcgttttg gctgatcgac gccgttcctt cgccatatgt cccaaccagg
     3661 catggcctgg ctctacccgg attgcagacc atgaatcttc ccaacgacca tatcgtcaag
     3721 agctacgacg aagagcagca gcgcctggtg gccgaaatcg tgcgcatggg cgagatggcc
     3781 gtcgcccagc tcgaagcgtc gatggacgtg atcgagaagc gcgatgagaa cgccgcccat
     3841 cgcatcatcg ccaacgatga agccatcgat gcactggaac agcagatcag ccacgacgtg
     3901 atgcgcctgg ccctgcgtgg cccgatggcc cgcgacctgc gcgagatcct ggctggcctg
     3961 cgcattccgg ccgacatcga gcgcattggc gattacgccg ccaacgtggc caagcgttcc
     4021 atcgccctgg gcaaggtgcc gccgctgccg cagatccagg gcctgcgtgc cctgggccga
     4081 ctggccgcac agcaggtgcg ccgcgccatc gccgcctacc gcgacaacga cgccgacgcc
     4141 gcgctggaac tgcgccagga cgacgcccgc ctggacgcgc agtacaccgc gctgttccgc
     4201 gagctgttga cctacatgat ggaagacccg cgcaacatca ccccgtgcac ccacctgctg
     4261 ttcatggcca agaacctgga acgcgtgggc gaccacgcca ccaacatcgc cgagaacgtg
     4321 tggttcctgg tgcatggcga gcagccgctg ccgccgcgtg aaaagcgcga cgagacctcc
     4381 agcaccggcc agccctgacg ctgcactgca acaccggagt tgactccaag gtggccgctg
     4441 tcctggtgac agcggccttc ttgtttccgg gcattccggc gattcatcca cgcatggcgt
     4501 ggatctaccg ggaaccgtgt tccccttctg taacaaacct cacgaaaatt tgaggtcttg
     4561 gcgaggattc gttgagtagg atcgctgcac catcgattcc accggcaccc ctgccggcga
     4621 cccgggcacc cgcccacacc acccaggagc accaccgatg agcagttcca acaagaccct
     4681 gtccctgctg actgctaccg ccctggccgc cggcctgggc atgaccgcca gtgcctcggc
     4741 cctgagcatg agcgacctgg cccagggcta tctggtcgct ggccaggcgg ccaaggccag
     4801 caccgatgcc aaggcagcgg acaccaagat ggccgcggac gcgaccaagc acgccgaagg
     4861 caaatgtggt gccgacggca agagtgccga aggcaagtgc ggcgccgaca agggcaaggc
     4921 cgccggtgct gcggcaggcg ccaaggccaa gagcggcgac aagaagtcgg ccgagggcaa
     4981 gtgcggcgaa ggcaagtgcg gtgcgaagca ctgacgtccg cgccagtgcc gtccacctgc
     5041 ggtcgccgct tcgtgcggcg gccgccgggt tggggctgcg ccgggcgctg ctgcaggatc
     5101 tgcgcgatgc accggcgggt gacttcgatt tcctcgaatg cgcgccggaa aactggatcc
     5161 atgtcggtgg tcccgccggg gatgcactgg ccgaactggc gcagcgccat ccgttgagct
     5221 gccacggcct gtcgttgtcg ctgggcggca gcgcacccct ggatacgcag ctgctggaac
     5281 aggtcggcca gttcctcgaa aagcaccgcg tgccgctgta cagcgagcac ctgagctact
     5341 gcagcgacga cggccacctg tacgacctgc tgccgattcc gttcaccgac gaagcagtgc
     5401 gccataccgc cgcgcgcatc gcccgcgtgc aggacctgct gggtcgccgc atcgcggtgg
     5461 agaacgtgtc ctactatctg gcaccggaac cggcgatgga cgaactggcc ttcaccaatg
     5521 ccgtgctcgc cgaggccgac tgcgacctgt tgctggacgt caacaacgtc tacgtcaacg
     5581 cctgcaacca tggctacgac gccgacagct tcattgccgc gctgcccgca gagcgcatcg
     5641 tctgcctgca cgtggccggg cacctggacg aggcaccgga cctgaagatc gatacccatg
     5701 gcagcgcggt gatcgatccc gtctgggacc tgctggcgcg tacctacgcg cgcatcggcc
     5761 cgcgccccac cctgctcgaa cgcgatttca atttcccgcc ctatgcagaa ctgcagggcg
     5821 aactgcagac catccgccgc ctgcaggcca cgcatgccgg ggtcgcacat ggctgatacc
     5881 tcccacaccc tgcgcgcgca gcagcacgcg ttcaccgcgc acctgcgtga tccgcaggcg
     5941 gtggccgcac cggtaggact ggaaccccgc cgggtcgcgg tgtaccaacg gctgctgttc
     6001 aacaatctgc tcggcctgtt gagcaacggc ttcccggtct gcttgcgcct gctcggcgaa
     6061 ccggcctgga gcgacctggt gcgctattac ttcgccaccc atcgctgcca gacgccgctg
     6121 ttcaccgaac tggctgccga attcgtgcag tggctgcagg cacagccgca gctgccgcac
     6181 ccggcgttgg ccgagctggc ccactacgag tgggtggaaa ccgcgctgta ccagcttcct
     6241 gccgagccgc tgccggcggc gggcaacatc gatccgctgc aggtaccgct gcagcgctcg
     6301 ccgctggcgt ggccgctgct gtaccagtgg ccggtgcacc ggctcggtgc cgaggatgca
     6361 ccgtcacaac cgccggacga accgaccggc ctgctggtcc gccgcgaggc cgatggcgag
     6421 gtgcgctttg ccgtactcag cccgctggcg gtgtacctgc tgtccagcat cggggaacac
     6481 cccggccttg atgggcatgc ctacctgcag cacctggcag ccgcgcacgg cctggccaag
     6541 gatgcgctgg ccggacccgg tgccgcgctg ctgcagcagt tcctgcaggc cggcgtgatc
     6601 ggcccgctcg cagtccccag ctgacgcccc ttcccccgga gaaccgccga tgaacactcc
     6661 gaccctagcc aacacgcgtg gccagctgga ccgtctcgcc ccctggttgg ccccgctcgg
     6721 cctgcgcctg ctgctggcct gggaatactt cgaatccggc cgcgagaaac tgcacggcca
     6781 gaactggttc gccgacctgc aggacgcctt cccgttcccg ttcgaccagc tgccggccac
     6841 cctgaactgg cagctcgcca cgtggttcga actgatcggc gcggtctgcc tgctggttgg
     6901 ctttggcacc cggtttgccg cggccagcct gctggtgctg accattgtgg ccacctatgc
     6961 ggtgcattgg ccgatggagt ggaactcgct ggccgacctc gccatgggct acgcgatcac
     7021 tgaccagggc ttcggcaatt tcaagctgcc ggtgctgttc atggcgatgc tgctgccgct
     7081 gatcttcacc ggcgccggca agctgagtgt ggatgcgtgg ttggcgcggc ggtctccctc
     7141 ggccacacct gcgcggccag cggttcggta gttgccgacc ctggtcggcg cgcaccgtgc
     7201 caaccaaggt tggcacctac cggaatcctg agcgcgcggt gccccggtag gcgtcgacct
     7261 tggtcgacac acgcccgcgc agggaacgca tgcaccgaag gctggccggg cgctcagggt
     7321 cgctctgcta gaattcacgc atgactgacc ccacccccgc acctgccgcc gctcccgatt
     7381 ccgtagtacc ccaggcgcag cgcgcgatgt cacagcgctt ccgcggcttc ctgccggtgg
     7441 tggtggatgt ggaaaccggc ggcttcgaca gccagcgcaa tgcactgctg gaaatcgccg
     7501 ccgtgccgat cgagatggac gagaacggcc tgctctaccc cggccagacc gccagcgccc
     7561 acgtggtgcc ggccgagggc ctggaaatcg atccgaaatc actggaagtg accggcatca
     7621 ttctcgacca cccgttccgg ctggccaagg aagagaagcc ggcactggac cacattttca
     7681 cccccgtgcg tgcagcgatg aagaaatacg gctgccagcg cgcgatcctg gtcggccaca
     7741 acgctcattt cgacctgggc ttcgtcaatg cggcggtggc gcggaccggc cacaagcgca
     7801 acccgttcca tccgttcagc gtgttcgaca cggtgaccct ggccggtatc gcctatggcc
     7861 agaccgtgct ggcacgtgcc gccaccgccg cggggctggg ctgggatgcg aacgaggcgc
     7921 acagcgcggt gtacgacacc gagcagaccg cgcggttgtt ctgcacgatc gccaacgcct
     7981 ggccgcggtg aagcagccaa cggcggagcc cctcgtggcg ggctgacagc gattcctgat
     8041 agggccgggc gggtggactg cgcaggggac gctgcaagta cgtccctgta agctcggtcg
     8101 ccgcatccat gcggctcacg cccctgcgca gcccacccgc ccggccacgg acagtttcca
     8161 gcgggcgcca cggaaagatc agaaaaagcg ggagcaacag cgggtcgctg cgctcgttag
     8221 gggctgccga tcacctctgt ggtgggtcac ttctctggtg gatgccgacc gttggtacgg
     8281 caacacccgt agatccacgc cacgcgtgga tgcgatcaac caatgctggt tcgatcgcgg
     8341 ccgtcgctct tggcgcggta cagcgcgcgg tccgcgcgct ggtacagcag tgccggggtg
     8401 cggtcgtcgg catccagttc caccaggcct gcgctgaacg tcacgcgcag gccgtccacg
     8461 ccggcccagt ccgggtggtc atggaacagg ccgcgcaggc gcgcgcacag ctgtgcggct
     8521 tcctccaggc gggtgtcgtt gagcagcagc gcgaactctt cgccaccggt ccgcgccggc
     8581 aggtccgaat cgcggctggc ggcggcaatc aaccgcgcca cctgcaccag caccgcatcg
     8641 ccgatgctgt ggctgtggcg atcgttgacg tccttgaagt gatcgatgtc gagcaccacc
     8701 aggcacaacg gatggccact gcgctgtgag cgggcgaaat cgcgcgccag ggtttcatcg
     8761 aaggcacggc ggttggccag gccggtcagg gcgtcttcgc gcgcctggcg ctcgaaggcc
     8821 tcggcctgcc gcgccaaccg ttcggccagt tcggtctttt cctggttcag cgcctgcagg
     8881 tgcacggtct tggcctgcag gtcgaaggtg gcttcatcca cccgccgcgc caggcgcagg
     8941 ttgctggcct tcaactgctg caacagcagc cggtacagcg ccaccagccc ggccagcagc
     9001 aacaggccac ccagcacctg cacactgcgt cgctgccacc agaacggctc cacggtgaag
     9061 ctccataccg cttcctgctg gccccagctg ccactcggat gggcagcggc cacgtgcaag
     9121 gtgtagtcgc ccggcggcag gccgacgaat tcgacactgc gctgcgggcc gcgctcgacc
     9181 cagccggcat ccagtccgtc cagccgcgtg cggtagcgga tccggtcaga catcaggtag
     9241 ctcaggccga catagctcac cgtcaaccgg cggccgccgg gaatgtagtt gcggtccggg
     9301 ccttcccaat gcaccggtgc gccatccacc tgcacgcttt caatcgctgc cggcggtgaa
     9361 aggcgctcac ggaagcgctg caggcgttgc gggtcgacgg tgctcaggcc tccggcggtg
     9421 accacccaga acgtgccgtc ctggcgcagg atcgccgatg ggctggagct gccgttggcc
     9481 tgtgcattgg ccatgccgtc gatctcgttg tagcgctcca ccactacccg cggcgtgcgg
     9541 ccatcgccca ctgcattgag ggtcgccatg tcggtgcgca acacaccgcg gttgctgctg
     9601 atccacacat tgccaaggcg gtccggcacc agttggaaca ccgcatccac cggcatgccc
     9661 tgctccagcc ccacccgcgc cagcgtgccg ttgcgccagc ggtacaagcc acggtcgctg
     9721 ctgatccaca tcgcgtcgcc cagctggtga aaaccgaaca cactgcggcc gccgcccagc
     9781 ggcgccaggt cgatcgactg cacgtggtca ccgcgcagca cgcggattcc ctcgatggtg
     9841 ccaatccaca ggttgccttg gtgatcgtgt tcaagcgcgg tgatcaggcc gctgggcatg
     9901 cccggaacgc tcgacacctg cacgcggtcg ccgtcgatgc ggaccacgcc cttctgcgtg
     9961 ccggcccaga ccacgccctg cgggtccacg ctgatcgcac ggatgttgcc gcccggcatg
    10021 ccatcggcgg cggcatagtt gtgtcgcagc cggccatcgc ggccaagacg gtagacgcca
    10081 tcgccgaacg ttccaaccca caggtcaccg tccggaccct gcgccaggct gagcaccgaa
    10141 ggtgccttgc cgccgcggtt gtgcagcggc atcgcgcgga agcggccatc ggcggtctgc
    10201 aggtcgaggc cgctggcgct gccgacccac agctggcggt cgcggtcctc gaacacggtg
    10261 cgcacgtagt caccgctgag accgtcgcgc tcggtgtaac tgctgaacag cgtttcgcgc
    10321 aggcggtaca ggccgccgtt ggcgcccacc cagatgctgc cctcggcgtc ctcgcgcagg
    10381 ctgaccacgc gcccaccggg caggttcagg cccgctggca gccgctccag gccatgtgag
    10441 gagatgcgca gcagaccctg gttctcggtg cccagccaca ggtcaccgtg gcggtcctgc
    10501 agcatcgagg tcatgtgcag ctggcccggc aggcggtgca tcaataccag ctggtcatct
    10561 tccacccggt acaggcgctc accggcgacg atccacagcg cgccatccgg agcgcggtac
    10621 ggccacgaca ggccactgcc ggcgcccagc ccccacgccg cgggcgcccg cttgagcacg
    10681 ccgtcgttgt cgcgcagcac cagcccatcg agggtgccgg cccagacccg gtcctgcgca
    10741 tcgaccacca gcttggtgaa gctcatcgcc atcggcaggt cagcggccgg agcctggtag
    10801 acgatgccgg tgtccggcgt cagatagccg atgcccttgc cttcatacag cagccacagg
    10861 cggccctggc tgtcca
//
