GCF_025449215.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP104900.1 (Shewanella seohaensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	arylpolyene	147,734	191,601	Low	APE Vf	other:other
Region 2	RiPP-like	1,255,863	1,268,049
Region 3	terpene-precursor	1,938,768	1,959,649
Region 4	hglE-KS,PUFA	2,002,704	2,058,981	High	eicosapentaenoic acid	PKS
Region 5	RiPP-like	2,467,983	2,478,822
Region 6	betalactone	3,317,794	3,349,201	Low	corynecin III/corynecin I/corynecin II	other:other
Region 7	lanthipeptide-class-i	3,419,774	3,444,166
Region 8	NI-siderophore	3,517,774	3,547,662	Low	desferrioxamine E	other:other
Region 9	RiPP-like	4,096,460	4,107,341

NZ_CP104900.1 - Region 1 - arylpolyene

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Location: 147,734 - 191,601 nt. (total: 43,868 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

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NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

N7V09_RS00735: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

N7V09_RS00845: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: acyltransferase halogenase

N7V09_RS00660: acyltransferase

smcogs: SMCOG1141: acyltransferase

N7V09_RS00715: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Lyases: cyclase

N7V09_RS00830: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: ligase synthase

N7V09_RS00680: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

N7V09_RS00690: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

N7V09_RS00725: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

N7V09_RS00740: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

N7V09_RS00710: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.75	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000836.5	0.63	other (other)	APE Ec	Escherichia coli CFT073
BGC0002008.3	0.62	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000866.5	0.53	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000837.4	0.50	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0001197.5	0.48	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002711.2	0.48	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002547.2	0.48	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis
BGC0000840.5	0.47	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.75	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000836.5	0.63	other (other)	APE Ec	Escherichia coli CFT073
BGC0002008.3	0.62	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000866.5	0.53	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000837.4	0.50	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0001197.5	0.48	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002711.2	0.48	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002547.2	0.48	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis
BGC0000840.5	0.47	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.40 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 21.55

Confidence: medium

Additional weak hits (13):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.99 out of 26.33

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.67 out of 29.38

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.42 out of 29.72

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.86 out of 21.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.10 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.85 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 29.41 out of 39.62

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.88 out of 21.55

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.17 out of 33.14

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.79 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.31 out of 35.63

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.16 out of 36.53

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

N7V09_RS00680: X

AMP-binding (130..350): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: THQ-----LFKWISFSSGGIEIFGSTETGGIAYR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP104900.1 - Region 2 - RiPP-like

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Location: 1,255,863 - 1,268,049 nt. (total: 12,187 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

N7V09_RS05760: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001285.5	0.31	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001791.4	0.23	NRPS	sunshinamide	Gynuella sunshinyii YC6258
BGC0002044.2	0.22	NRPS	empedopeptin	Massilia sp. YMA4
BGC0001586.3	0.19	saccharide	EPS273	Pseudomonas stutzeri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001285.5	0.31	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001791.4	0.23	NRPS	sunshinamide	Gynuella sunshinyii YC6258
BGC0002044.2	0.22	NRPS	empedopeptin	Massilia sp. YMA4
BGC0001586.3	0.19	saccharide	EPS273	Pseudomonas stutzeri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.96 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.74 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_CP104900.1 - Region 3 - terpene-precursor

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Location: 1,938,768 - 1,959,649 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase synthetase

N7V09_RS08705: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

N7V09_RS08710: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001361.3	0.46	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.46	terpene	sodorifen	Serratia plymuthica
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000668.5	0.36	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001594.3	0.36	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000666.5	0.35	terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0001501.5	0.34	other (other)	ambiguine P	Fischerella sp. TAU

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001361.3	0.46	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.46	terpene	sodorifen	Serratia plymuthica
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000668.5	0.36	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001594.3	0.36	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000666.5	0.35	terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0001501.5	0.34	other (other)	ambiguine P	Fischerella sp. TAU

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

N7V09_RS08710: PT_FPPS_like

Domain 1 (31 - 292): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.67 out of 27.78

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.87 out of 27.78

Confidence: medium

Additional weak hits (3):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.81 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.48 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.07 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_CP104900.1 - Region 4 - PUFA,hglE-KS

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Location: 2,002,704 - 2,058,981 nt. (total: 56,278 nt) Show pHMM detection rules used

hglE-KS: (hglE or hglD)
PUFA: PUFA_KS

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase acylase formyltransferase phosphotransferase

N7V09_RS09045: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

N7V09_RS09070: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

N7V09_RS09150: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

N7V09_RS09155: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Isomerases: mutase

N7V09_RS08995: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthase

N7V09_RS09050: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

N7V09_RS09060: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002648.2	1.09	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000861.5	1.08	other (other)	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000862.3	0.71	other (other)	eicosapentaenoic acid	Shewanella pneumatophori
BGC0001276.3	0.51	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.51	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000863.3	0.50	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0001254.3	0.49	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.48	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.48	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000869.5	0.45	other (other)	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002648.2	0.81	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000861.5	0.81	other (other)	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000862.3	0.68	other (other)	eicosapentaenoic acid	Shewanella pneumatophori
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000863.3	0.59	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0001254.3	0.58	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000869.5	0.55	other (other)	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.83 out of 20.47

Confidence: medium

Additional weak hits (11):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.49 out of 30.22

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 36.53

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.31 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.28 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.73 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.16 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.94 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.93 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.87 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 2002703 - 2058981:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

N7V09_RS09055: pk

PKS_AT (366..670): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

N7V09_RS09060: mal

PKS_AT (604..911): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 89.5
inactive: 36.4
Methoxymalonyl-CoA: 29.4
Methylmalonyl-CoA: 22.0
Isobutyryl-CoA: 14.0
fatty_acid: 11.5
Propionyl-CoA: 4.2
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP104900.1 - Region 5 - RiPP-like

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Location: 2,467,983 - 2,478,822 nt. (total: 10,840 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: esterase

N7V09_RS11060: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0002669.2		0.22	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001387.5		0.20	other (other)	nucleocidin	Streptomyces calvus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0002669.2		0.22	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001387.5		0.20	other (other)	nucleocidin	Streptomyces calvus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 25.29 out of 29.25

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.05 out of 26.85

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

Additional weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.19 out of 26.06

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.99 out of 29.38

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.96 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MexT	Global virulence regulator
RutR	Regulator of the pyrimidine and purine metabolism
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis

NZ_CP104900.1 - Region 6 - betalactone

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Location: 3,317,794 - 3,349,201 nt. (total: 31,408 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

N7V09_RS14860: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

N7V09_RS14905: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

N7V09_RS14930: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase

N7V09_RS14935: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

N7V09_RS14945: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

N7V09_RS14940: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

N7V09_RS14915: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

N7V09_RS14950: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.54	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000234.5	0.45	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001778.5	0.43	other (other)	showdomycin	Streptomyces showdoensis
BGC0000207.5	0.42	PKS	chartreusin	Streptomyces chartreusis
BGC0000597.4	0.41	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000253.4	0.41	PKS	oviedomycin	Streptomyces antibioticus
BGC0000913.3	0.40	other (other)	MK-8	Enterobacter cloacae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.54	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000234.5	0.45	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001778.5	0.43	other (other)	showdomycin	Streptomyces showdoensis
BGC0000207.5	0.42	PKS	chartreusin	Streptomyces chartreusis
BGC0000597.4	0.41	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000253.4	0.41	PKS	oviedomycin	Streptomyces antibioticus
BGC0000913.3	0.40	other (other)	MK-8	Enterobacter cloacae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.75 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.04 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.62 out of 20.97

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.83 out of 24.78

Confidence: medium

Additional weak hits (5):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.79 out of 31.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.48 out of 29.65

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.71 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.44 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CP104900.1 - Region 7 - lanthipeptide-class-i

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Location: 3,419,774 - 3,444,166 nt. (total: 24,393 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

N7V09_RS15380: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase

N7V09_RS15395: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

Lyases: cyclase dehydratase

N7V09_RS15410: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

N7V09_RS15415: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

N7V09_RS15420: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002640.2	0.71	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0001555.4	0.49	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002005.2	0.48	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000590.5	0.48	ribosomal	microcin N	Escherichia coli
BGC0001289.5	0.47	ribosomal	penisin	Paenibacillus ehimensis
BGC0000588.5	0.46	ribosomal	microcin L	Escherichia coli
BGC0000540.5	0.46	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000542.3	0.46	ribosomal	paenicidin B	Paenibacillus terrae
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002640.2	0.71	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0001555.4	0.49	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002005.2	0.48	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000590.5	0.48	ribosomal	microcin N	Escherichia coli
BGC0001289.5	0.47	ribosomal	penisin	Paenibacillus ehimensis
BGC0000588.5	0.46	ribosomal	microcin L	Escherichia coli
BGC0000540.5	0.46	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000542.3	0.46	ribosomal	paenicidin B	Paenibacillus terrae
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for N7V09_RS15415

allorf_3429438_3429629

Leader:

MMELKLKKTELVNLSQDKKVLPSELTPQ

Core:

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

Core with dehydrations:

IAGGVGDhbRDhaCysGEIDhbANAYDhbCysPDhaDRDhbGDhaDhbLRCysCysQIP

antiSMASH-DB 4.0 matches for allorf_3429438_3429629

100.0%

NZ_CP104900.1and 1 other:

NZ_CP104900.1 Lanthipeptides: allorf_3429438_3429629_lanthipeptide

Lanthipeptides: allorf_3429438_3429629_lanthipeptide

1

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

1

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

85.7%

NZ_JAAPAV010000001.1and 1 other:

NZ_QNSC01000013.1 Lanthipeptides: DET47_RS16520_lanthipeptide

Lanthipeptides: HUB64_RS17000_lanthipeptide

1

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

+AGGV TR+CGE+TANAYTCPSDRTGST RCCQIP

1

VAGGVITRACGELTANAYTCPSDRTGSTHRCCQIP

35

40.5%

NZ_FUWZ01000001.1:

Lanthipeptides: B5D63_RS07910_lanthipeptide

1

IAGGVGTRS--CGEITANAYTCPSDRTGSTLRCCQIP

35

+ GGV TR C E T +C + R CCQIP

1

LVGGVATRDIVCMEDTRYISSCRATRPSPNSPCCQIP

37

with 11 more sequence matches

Only the first 10 are displayed here.

35.1%

NZ_CP073766.1:

Lanthipeptides: KD145_RS08715_lanthipeptide

1

IAGGVGTR--SCGEITANAYTCPSDRTGSTLRCCQIP

35

+ GG+ T +C E T +C + R CCQIP

1

LVGGINTLYLTCTEDTRAISSCRATRPSPNATCCQIP

37

34.9%

NZ_CP051204.2and 1 other:

NZ_CP051205.1 Lanthipeptides: HF329_RS14580_lanthipeptide

Lanthipeptides: HF324_RS23005_lanthipeptide

1

IAGGVGTRS--CGEITANAYTCPSDRTGSTLRCCQIP

35

+ GGV TR C E T +C + R CCQIP

7

LVGGVATRDIVCMEDTRYISSCVATRPSPNSPCCQIP

43

34.3%

NZ_LR655208.1:

Lanthipeptides: FS985_RS23940_lanthipeptide

1

IAGG--VGTRSCGEITANAYTCPSD

23

IAGG V T S + N TCP D

2

IAGGMPVTTWSVCCVKTNEATCPDD

26

34.1%

NZ_JAGPNM010000006.1:

Lanthipeptides: J3B89_RS14930_lanthipeptide

1

IAGGVGTRSCGEITANAYTCP----SDRTGSTLRCCQIP

35

+ GG T C + + ++ P SD TG T CCQIP

6

VGGGAVTEWCPQPSVDSPNRPGCRISDPTGMTSPCCQIP

44

33.3%

NZ_LR655208.1:

Lanthipeptides: FS985_RS23945_lanthipeptide

1

IAGGVGTRS-CGEITANAYTCPSDRTGSTLRCCQIP

35

+ GG G C + T +C + G+ CCQIP

1

LLGGFGVSVLCTDDTRQISSCRATSPGTGRPCCQIP

36

31.7%

NZ_JAABOK010000018.1:

Lanthipeptides: GWG06_RS26535_lanthipeptide

1

IAGG--VGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

+AGG V S E T +C + R + CC IP

5

LAGGFIVTVTSACEDTRQISSCIATRPRPNMTCCMIP

41

25.7%

NZ_NVEA01000022.1:

Lanthipeptides: COL15_RS32130_lanthipeptide

16

NAYTCPSDRTGSTLRC

31

N YTCPS T T++C

16

NLYTCPS--TPCTIQC

29

25.7%

NZ_QLLL01000002.1:

Lanthipeptides: LX64_RS25750_lanthipeptide

19

TCPSDRTGSTLRCCQIP

35

+C + R ST CCQIP

15

SCIATRPSSTRPCCQIP

31

20.0%

NZ_JANAVO010000004.1and 3 others:

NZ_JANAVO010000004.1 Lanthipeptides: NLX83_RS25550_lanthipeptideNZ_JANAVO010000004.1 Lanthipeptides: NLX83_RS25550_lanthipeptideNZ_JANAVO010000004.1 Lanthipeptides: NLX83_RS25550_lanthipeptide

Lanthipeptides: NLX83_RS25550_lanthipeptide

17

AYTCPSDRTGSTLRCCQI

34

A+T PS R+ + CC +

6

AFTFPSIRSMMPIGCCSL

23

13.6%

NZ_JALBFU010000003.1:

Lanthipeptides: allorf_286151_286330_lanthipeptide

12

EITANAYTCP

21

E ANA+ CP

6

EFAANAHRCP

15

Lanthipeptide(s) for N7V09_RS15420

allorf_3429438_3429629

Leader:

MMELKLKKTELVNLSQDKKVLPSELTPQ

Core:

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

Core with dehydrations:

IAGGVGDhbRDhaCysGEIDhbANAYDhbCysPDhaDRDhbGDhaDhbLRCysCysQIP

antiSMASH-DB 4.0 matches for allorf_3429438_3429629

100.0%

NZ_CP104900.1and 1 other:

NZ_CP104900.1 Lanthipeptides: allorf_3429438_3429629_lanthipeptide

Lanthipeptides: allorf_3429438_3429629_lanthipeptide

1

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

1

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

85.7%

NZ_JAAPAV010000001.1and 1 other:

NZ_QNSC01000013.1 Lanthipeptides: DET47_RS16520_lanthipeptide

Lanthipeptides: HUB64_RS17000_lanthipeptide

1

IAGGVGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

+AGGV TR+CGE+TANAYTCPSDRTGST RCCQIP

1

VAGGVITRACGELTANAYTCPSDRTGSTHRCCQIP

35

40.5%

NZ_FUWZ01000001.1:

Lanthipeptides: B5D63_RS07910_lanthipeptide

1

IAGGVGTRS--CGEITANAYTCPSDRTGSTLRCCQIP

35

+ GGV TR C E T +C + R CCQIP

1

LVGGVATRDIVCMEDTRYISSCRATRPSPNSPCCQIP

37

with 11 more sequence matches

Only the first 10 are displayed here.

35.1%

NZ_CP073766.1:

Lanthipeptides: KD145_RS08715_lanthipeptide

1

IAGGVGTR--SCGEITANAYTCPSDRTGSTLRCCQIP

35

+ GG+ T +C E T +C + R CCQIP

1

LVGGINTLYLTCTEDTRAISSCRATRPSPNATCCQIP

37

34.9%

NZ_CP051204.2and 1 other:

NZ_CP051205.1 Lanthipeptides: HF329_RS14580_lanthipeptide

Lanthipeptides: HF324_RS23005_lanthipeptide

1

IAGGVGTRS--CGEITANAYTCPSDRTGSTLRCCQIP

35

+ GGV TR C E T +C + R CCQIP

7

LVGGVATRDIVCMEDTRYISSCVATRPSPNSPCCQIP

43

34.3%

NZ_LR655208.1:

Lanthipeptides: FS985_RS23940_lanthipeptide

1

IAGG--VGTRSCGEITANAYTCPSD

23

IAGG V T S + N TCP D

2

IAGGMPVTTWSVCCVKTNEATCPDD

26

34.1%

NZ_JAGPNM010000006.1:

Lanthipeptides: J3B89_RS14930_lanthipeptide

1

IAGGVGTRSCGEITANAYTCP----SDRTGSTLRCCQIP

35

+ GG T C + + ++ P SD TG T CCQIP

6

VGGGAVTEWCPQPSVDSPNRPGCRISDPTGMTSPCCQIP

44

33.3%

NZ_LR655208.1:

Lanthipeptides: FS985_RS23945_lanthipeptide

1

IAGGVGTRS-CGEITANAYTCPSDRTGSTLRCCQIP

35

+ GG G C + T +C + G+ CCQIP

1

LLGGFGVSVLCTDDTRQISSCRATSPGTGRPCCQIP

36

31.7%

NZ_JAABOK010000018.1:

Lanthipeptides: GWG06_RS26535_lanthipeptide

1

IAGG--VGTRSCGEITANAYTCPSDRTGSTLRCCQIP

35

+AGG V S E T +C + R + CC IP

5

LAGGFIVTVTSACEDTRQISSCIATRPRPNMTCCMIP

41

25.7%

NZ_NVEA01000022.1:

Lanthipeptides: COL15_RS32130_lanthipeptide

16

NAYTCPSDRTGSTLRC

31

N YTCPS T T++C

16

NLYTCPS--TPCTIQC

29

25.7%

NZ_QLLL01000002.1:

Lanthipeptides: LX64_RS25750_lanthipeptide

19

TCPSDRTGSTLRCCQIP

35

+C + R ST CCQIP

15

SCIATRPSSTRPCCQIP

31

20.0%

NZ_JANAVO010000004.1and 3 others:

NZ_JANAVO010000004.1 Lanthipeptides: NLX83_RS25550_lanthipeptideNZ_JANAVO010000004.1 Lanthipeptides: NLX83_RS25550_lanthipeptideNZ_JANAVO010000004.1 Lanthipeptides: NLX83_RS25550_lanthipeptide

Lanthipeptides: NLX83_RS25550_lanthipeptide

17

AYTCPSDRTGSTLRCCQI

34

A+T PS R+ + CC +

6

AFTFPSIRSMMPIGCCSL

23

13.6%

NZ_JALBFU010000003.1:

Lanthipeptides: allorf_286151_286330_lanthipeptide

12

EITANAYTCP

21

E ANA+ CP

6

EFAANAHRCP

15

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

Additional weak hits (2):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.74 out of 30.22

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.14 out of 25.75

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

allorf_3429438_3429629 - Class I

Cleavage pHMM score: -6.50

RODEO score: 18

Monoisotopic mass: 3413.6 Da

Molecular weight: 3415.8 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3433.8 Da N = 1; 3451.9 Da N = 2; 3469.9 Da N = 3; 3487.9 Da N = 4

allorf_3429438_3429629 - Class I

Cleavage pHMM score: -6.50

RODEO score: 18

Monoisotopic mass: 3413.6 Da

Molecular weight: 3415.8 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3433.8 Da N = 1; 3451.9 Da N = 2; 3469.9 Da N = 3; 3487.9 Da N = 4

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 162 - 239; Score: 34.1

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP104900.1 - Region 8 - NI-siderophore

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Location: 3,517,774 - 3,547,662 nt. (total: 29,889 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

N7V09_RS15795: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

N7V09_RS15860: aldehyde oxidase and xanthine dehydrogenase

smcogs: SMCOG1293: aldehyde oxidase and xanthine dehydrogenase

Isomerases: isomerase

N7V09_RS15755: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase

N7V09_RS15760: carbamoyl phosphate synthase small subunit

smcogs: SMCOG1249: carbamoyl phosphate synthase small subunit

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.3	0.61	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0001478.5	0.60	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.59	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002464.3	0.57	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002305.2	0.57	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.51	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.51	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0002469.2	0.50	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002031.3	0.49	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.3	0.61	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0001478.5	0.60	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.59	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002464.3	0.57	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002305.2	0.57	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.51	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.51	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0002469.2	0.50	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002031.3	0.49	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.38 out of 26.33

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.69 out of 30.25

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.41 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.11 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.09 out of 29.38

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.73 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.73 out of 30.25

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.71 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.44 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
ColR	Phenol-responsive regulator

NZ_CP104900.1 - Region 9 - RiPP-like

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Location: 4,096,460 - 4,107,341 nt. (total: 10,882 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description