LOCUS       NZ_CP104864            24529 bp    DNA     linear   CON 13-OCT-2024
DEFINITION  Streptomyces lusitanus strain FZ202 chromosome.
ACCESSION   NZ_CP104864
VERSION     NZ_CP104864.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lusitanus
  ORGANISM  Streptomyces lusitanus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7417890)
  AUTHORS   Zhang,F.
  TITLE     Streptomyces lusitanus FZ202
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7417890)
  AUTHORS   Zhang,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-SEP-2022) College of Life Science and Technology,
            Jinan University, Guangzhou, Guangzhou, Guangdong 510632, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAY-2021
            Assembly Method                   :: unicycler v. 3.14.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 213.8x
            Sequencing Technology             :: Illumina NovaSeq6000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025427835.1-RS_2024_10_11
            Annotation Date                   :: 10/11/2024 19:56:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,707
            CDSs (total)                      :: 6,615
            Genes (coding)                    :: 6,460
            CDSs (with protein)               :: 6,460
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 83 of 155
            Pseudo Genes (incomplete)         :: 88 of 155
            Pseudo Genes (internal stop)      :: 3 of 155
            Pseudo Genes (multiple problems)  :: 19 of 155
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:00:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 255709
            Orig. end                         :: 280238
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP104864.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zhang Fei,  College of Life
            Science and Technology.
FEATURES             Location/Qualifiers
     region          1..24529
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24529
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24529
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14529](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14529
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            99..1049
                     /locus_tag="N7E53_RS01030"
                     /pseudo=""
     CDS             99..1049
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894632.1"
                     /locus_tag="N7E53_RS01030"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPAAEPGLPEESWRWTEPTWRGHVDAVRAGRRLVPDRWPGGARAA
                     VALSFDSDHETIPLRDGETSPGRLAQGEYGARVGAPRILRLLAQHGVPATFFMPAVSAL
                     LHPEEARAYTEDGHELAVQAGSTSGTRCWAARTSGS"
     gene            1046..2371
                     /locus_tag="N7E53_RS01035"
     CDS             1046..2371
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523025.1"
                     /locus_tag="N7E53_RS01035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_261674473.1"
                     /transl_table=11
                     /translation="MNLKSDLSPGSPAAGGASEPQKLNAKQRKAIVAGTIGNTVEWVDW
                     ALYSIFAKIIADEFFPKGNGAVALLSTLAVFAVGFVMRPVGAAVLGAYADRHGRKKGMT
                     LTVALMAGAGFAIAVTPGYEHIGVLSPLLLLVARLMQGFSAGGEFGSSSAFLVESAARG
                     RRAFAGSWQQVSVAGGVLIASLLGTLTTSALSDEALHSWGWRVAFVFGGLLGLVGLWLR
                     VSVEDTESFARSQDGGRTRTNPVKAMFVEHPAATLRVVGITIAGTLTYYIWVNYLPTYA
                     NLTTGIPLKTALLSQTLCLVVFVIALPFAGLLSDRIGRRPTMAAFAGGFVVLAWPLLHL
                     LGDSFWSLFPVQLVGMLLILGYSSNCAVIMAEQFPAEVRATGIALPYALAVAVFGGTAP
                     YVTTWMHESGHSGLLWIYVSAASLISLVVYLTMPETKDKDFT"
     gene            2368..3201
                     /locus_tag="N7E53_RS01040"
     CDS             2368..3201
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (3-164). E-value: 1e-12. Score:
                     40.3. Matches aSDomain:
                     nrpspksdomains_N7E53_RS01040_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158266.1"
                     /locus_tag="N7E53_RS01040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_261674474.1"
                     /sec_met_domain="adh_short (E-value: 2e-31, bitscore:
                     108.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 8.8e-05, bitscore:
                     20.3, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.2e-30, bitscore:
                     103.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHILVTGAAGGIGSAIAEAFAARAAFLTLSDRDVDALRATAARI
                     EGSTAIRAADLSDPDAATDLVEQSWAAHGPVDVLVNAAGVYPSLDMADVDAESWDRLFA
                     VNLRAPVLATAALARLAAAAGRPASVVNISSGSALRSRPGGGPYASSKAALEMATRAAA
                     LELGALGIRVNAVSPGFVLVDSDVNPVSAEYARSIDVNPLGRPGTPEDVARAVCWLAGP
                     EASWITGETVRVDGGSSTGALHLPRIWQADGTRATRTTHAEAPVGAGTTTEEATR"
     aSDomain        2377..2859
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_N7E53_RS01040_PKS_KR.1"
                     /evalue="1.00E-12"
                     /label="N7E53_RS01040_PKS_KR.1"
                     /locus_tag="N7E53_RS01040"
                     /protein_end="164"
                     /protein_start="3"
                     /score="40.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ILVTGAAGGIGSAIAEAFAARAAFLTLSDRDVDALRATAARIEGS
                     TAIRAADLSDPDAATDLVEQSWAAHGPVDVLVNAAGVYPSLDMADVDAESWDRLFAVNL
                     RAPVLATAALARLAAAAGRPASVVNISSGSALRSRPGGGPYASSKAALEMATRAAAL"
     CDS_motif       2380..2445
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_N7E53_RS01040_0001"
                     /evalue="7.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="N7E53_RS01040"
                     /protein_end="26"
                     /protein_start="4"
                     /score="18.7"
                     /tool="antismash"
                     /translation="LVTGAAGGIGSAIAEAFAARAA"
     gene            3198..5408
                     /locus_tag="N7E53_RS01045"
     CDS             3198..5408
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523027.1"
                     /locus_tag="N7E53_RS01045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_261674475.1"
                     /transl_table=11
                     /translation="MSDITQDAAAYTVVGGGAIGGTLAFALARAGHPVTVVDADPAHVE
                     AIRTHGLVLARSDRRTSVPVRAVTPDAFDGRLGRVLLAVKAQATRGAVEWIAPRLEPDG
                     YVVSVQNGFNEDLIAEYVGIGRTVAAFVNIFADVVEPGVILDGGAGALVIGEPKGAPVG
                     ERVRSLVADLQSWGPARASDNVEGYLWAKAGFGAMLAATALADAPMADLIDRHRSAMAA
                     LTAEVFAVADRRGVTLQAFDAFDPEPFRQGADAGAREAAFDRLTAWLRTQSKDRSGIWR
                     DLAVRHRPVEVTTHYRDVIAYATELGLPTTLLRTVMDGLRELEGAPETMSEGRLDALDR
                     LTGPNLDDVDPGVRVRRWLEEHREEMVADLAAYTARGSASDDLDALDACLAWLRGWLDE
                     RLGAAESEEILGREDAGDVLVRRYPARDATTADARPVLLLGHYDTVWPTGTLESWPFRR
                     DGDTVTGPGVFDMKAGLVQAVWALRALDALGLPRPAVTLMLNGDEETGSLASRDAIVET
                     GRDCRLAMVFEAAVDGAIKTARKGVGLFTLTVTGSEAHAGLDPTAGASAVDELAYQILR
                     LAELRDLEAGTSLNVGVIEGGTRGNVTAGRASAHLDVRVASAAEQDRITRALADLRPVD
                     PGTRLEVTGDWNRPVFERGEQVAWAAGLAKDAARRLGHDLTEAAVGGASDGNFLAAAGV
                     PVLDGIGAVGHGAHARTECTSVAGMVFRSALTGGVLVRLAGE"
     gene            complement(5778..7841)
                     /locus_tag="N7E53_RS01050"
     CDS             complement(5778..7841)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125451.1"
                     /locus_tag="N7E53_RS01050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_261674476.1"
                     /transl_table=11
                     /translation="MNSPRPSSDLAAVTTWWNGLACNGFFVLPPPTRRRFTQADGHEEA
                     ALLLAARGGRGGTATDTTRPASFAYWHWDAHRNAFDRSGTLTGELLLHWGGDHATVAAG
                     LGEGPPGFGIVDGGPRSAFRLDRITHRDDDGLPDPSDPDGVRQFLSMLGEPVDRAAPRL
                     TYGPLSPAEAAWLHARLDEAPDVSAAARFAIPLEQRDELTADETERLLHAWQAEYAGRL
                     TEWNAGSAVLHALLRHGHAAAWDIVAVYGLRAYGVLSDVPTAQGLRVVREAALAGDRGA
                     LRAWLSLHRSLHEPDAVRAASALAAELTAHGASESSLRGLYEALIGAAVTDRRRDTGAG
                     PGSVDLHAGLAAVRFSTDERLPHALRVLAAAAARDRAELVREEALRPGSAVLTDTEQSE
                     ALAALDRYEAARDALSSATGPDLDTYEGALCAVWHHYRTLTDADAHWLRERVADPGTGL
                     QGLGFCLELLHSHGLAGRHEIEALLPHRLKDLTKKYETTYTEWRHPLVTLTCLALDLDH
                     PEAGRLVSWWNRARPVWKDKLRLLTHLGAPDETKAAELWDFVTSSAHDVGQLMTYVLVR
                     ARLDGEHPLLVADRLIGAPGIRDRVLHRVLLGVADPAQPLWHYAVKSSSRSWWQRAREV
                     AEDTRLSSEGRAIGLRAARDHALIRYSDRLKPPPSEAERAQALAWLTGHGES"
     gene            7970..8758
                     /locus_tag="N7E53_RS01055"
     CDS             7970..8758
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643304.1"
                     /locus_tag="N7E53_RS01055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_261674477.1"
                     /transl_table=11
                     /translation="MARGTVRGHRVVGAGLVLLLASAGCGSPAGDSGDGGATAAPPVRD
                     KGPVCVGEAPADGVRVLRGGGFRLPGGTGVQYAGASADGSSRTATLREGARYEEGQREW
                     KVAVGARVPLAGHAYTVRQVCSYRVVLEAASARDASALAEAPASMTSTGGEADAGLCFT
                     TNRAVLKAAADGSPAEGESLSLVGNGGVRRFPTGLSLTVSYLDAEAGTAGIAANCAAVP
                     VAAYEELRVGDPLELGGVLFEVTDVTEAVVRLTRPAAPRP"
     gene            complement(8768..9220)
                     /locus_tag="N7E53_RS01060"
     CDS             complement(8768..9220)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023580.5"
                     /locus_tag="N7E53_RS01060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3592 domain-containing protein"
                     /protein_id="WP_193454572.1"
                     /transl_table=11
                     /translation="MIATLFGLALVTLTAFLMFLLPGRSLVNDLRSRGISVVAEVTAAS
                     KNKYGDAGNVKVRFDGPDGTVETELHDWGGKRPEGLRAGAAVPVTYDPREPTRVLTTRW
                     VEDPPTATLPMLVTAVLTPLLLSGAVFLVVRRRRLLKAGEQADPTA"
     gene            9749..9910
                     /gene="lanA"
                     /locus_tag="N7E53_RS01070"
     CDS             9749..9910
                     /codon_start=1
                     /gene="lanA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) strep_PEQAXS"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978597.1"
                     /locus_tag="N7E53_RS01070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SCO0268 family class II lanthipeptide"
                     /protein_id="WP_058915350.1"
                     /sec_met_domain="strep_PEQAXS (E-value: 2.8e-40, bitscore:
                     134.7, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTEIVLSQDAPELDLDLDLRVSDLPEQAESFGQGTYTSPSSYAI
                     GTRCPVCC"
     CDS_motif       9749..9835
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRTEIVLSQDAPELDLDLDLRVSDLPEQA"
                     /locus_tag="N7E53_RS01070_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9836..9910
                     /prepeptide="core"
                     /locus_tag="N7E53_RS01070_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.70"
                     /molecular_weight="2388.6"
                     /monoisotopic_mass="2387.1"
                     /core_sequence="ESFGQGTYTSPSSYAIGTRCPVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRTEIVLSQDAPELDLDLDLRVSDLPEQA"
                     /leader_location="[9748:9835](+)"
                     /alternative_weights="2406.6"
                     /alternative_weights="2424.7"
                     /alternative_weights="2442.7"
                     /alternative_weights="2460.7"
     gene            10001..13156
                     /locus_tag="N7E53_RS01075"
     CDS             10001..13156
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978596.1"
                     /locus_tag="N7E53_RS01075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_261674478.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.5e-170,
                     bitscore: 565.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-15,
                     bitscore: 56.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.7e-28, bitscore:
                     97.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAECEAGQASAAFEVRDPVLVRMASRPRGTDLEGVDAADPVPGA
                     RRLAADPVLGQAVRVASGSLAHSLDRLTGDEGVAALGRKRTLSAARTLTRYARRAAARP
                     TPFGLFAGVGRARFGSAAKAEPGAGEVAVRLDGAWLRRRVMAWLAEPSVRRRVDVVLND
                     LCFVRDGRLCLRTGGQERSVRDNALVGAVRERTRTLVGYGDLLDTLTRRFPSLDAERLD
                     GQLAELVRRGFLLTSLTPHRIDTALLDGIEAVLDEALPDDARALRDIRAACARHERDSP
                     EAGGESWHRLLDEVRRLDVPGTDGDAQARPPVHVDLHMRGEFVLPETVGREVCRYAGAI
                     WSVTPEWTTLAYMRDYRDRFIERYGTACAVPLGELADPHRGLGLPPEYGAEPTYARTGP
                     GDEVDGPRRAFVGELIQEAVLSGGDLVLTDEVVRRLADVARHDPEAAPPRGLELCFQVL
                     ADSTAALDRGDFRLLGSPHIGAWAAGATAGRFAEAAGLTADLTRLAAETSGDPDGDVIA
                     AQVELLPREPRGLNIVQVPRLLPYRIPVGVPDDRDDPRCLDWRTLLVAAGSDGLRLLHP
                     ESGRPVRPVLPHMLALDAQAPPVARFLMDLATARPRVWSGWDWAGHDTLPYLPRVRYGR
                     VVVMPKRWLPGRRLRDAARAKGAEVWEEGLDAWRRRLTVPDRLHIARNDQMYPVDLRDR
                     WDRELLRSELTALHPQFVLYEDLTTDGAGLGWNGGHSTEIVVPLAGARPSGGATGTGSR
                     GQARTAPPVRLAPTRFHLPGEDWLFAKWYAEPSAHEALLADHLPAVLGEIEDDVDRWFF
                     VRYQDPDPHLRLRFHGDVEALNGRVLPALSRASRVLVESGALRSMTLDTYRPESDRYGG
                     EALQEAAERLFRTDSLSAVVHLRAARGAARGLPADVLAGLGHAVLLESLGDWDWCGWVD
                     RMFTKSEEHEVYQRQRALADRLITPGNVVASAVEALGAPALRSLWADSDEPRAYGRAVL
                     SAPEADRDEALLSLLHMRHNRHFGIDRSAEARGYAVLRGAVRSHLGRQRHRGDHGNGNG
                     SGR"
     aSDomain        10475..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_N7E53_RS01075_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="5.10E-18"
                     /identifier="RREFam001.1"
                     /label="N7E53_RS01075"
                     /locus_tag="N7E53_RS01075"
                     /protein_end="241"
                     /protein_start="158"
                     /score="56.5"
                     /tool="antismash"
                     /translation="VVLNDLCFVRDGRLCLRTGGQERSVRDNALVGAVRERTRTLVGYG
                     DLLDTLTRRFPSLDAERLDGQLAELVRRGFLLTSLTPH"
     gene            13153..14529
                     /locus_tag="N7E53_RS01080"
     CDS             13153..14529
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523032.1"
                     /locus_tag="N7E53_RS01080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_261674479.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-59, bitscore:
                     200.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGAADVSAKGGEARERADGAATRGLRERAGAVSAAILERLADPA
                     ATVAATRIPSEAADDGVAEPVWAELTLGSGSPGLALAFAGAARDPERQVPRAHAYLTAG
                     TRAVSGGPGAASGIFKGPGALAFAVLVAHRTTGGYVSALGRFDAYQRDLVRTVLPPVED
                     RPLSTIGHYEVVRGLTGVGRYLLARAETCEEPLTAVLDHLVRLSVGTVEHQGARVPRWW
                     ALDAPRTGSEEAFPGGHLNLGLSHGVAGPLALMALAWEQGVRVPGQQEAMEATAGLLRA
                     WAVTDRHGVFWPGHLSFAEWRRGPAAYDGRAKWPAWCYGAPGVSRALQLAGRALGRSDL
                     SDLARASVDRLLALPRSDWGINDHALCHGWAGALHQLGRLDEEWRDPRLARLRDDIASE
                     LVTAFDPALPFGLRFTMTKVPFGSDVSGYLDGAAGVALALDSYAVDGTPADWDMPLLLA
                     "
     gene            14625..15791
                     /locus_tag="N7E53_RS01085"
     CDS             14625..15791
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175331.1"
                     /locus_tag="N7E53_RS01085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_315968219.1"
                     /transl_table=11
                     /translation="MITRRRLLMSTAAAAVAGTAVPAAAATARSPSRSLQRDADALRDA
                     GVTGVAVRLDTPHGTVTARSGVRDLRSLGPVPEGGYLRLGSTTKTFVATVLLRLVGERR
                     VSLDQTVDDLLPAVVQGAGNDGRTITVRHLLRHTSGLPDYVPDVFPEQSAETYFARRWR
                     AYEAEELVRLAVRHRPTFPAGTGWAYSNTNYVLAGLIIERITGRGWEREVADRILRPLG
                     LRHTDTPGTRPFLPHPHTSNYQQFTEGGPLVDTTLPYRPFDSGADGSMTGTARDLNRFF
                     SALAGGRLLAPAELNAMRDTVEVPPGNGHPVGARAGLGLFHTPLSGGGGCLGHSGSGFG
                     YVVETATTLDGRRTVTVSAHSRSADPEQAARQETALRDLIDHALSRGD"
     gene            15863..16273
                     /locus_tag="N7E53_RS01090"
     CDS             15863..16273
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523034.1"
                     /locus_tag="N7E53_RS01090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RidA family protein"
                     /protein_id="WP_037643554.1"
                     /transl_table=11
                     /translation="MTAEITRINPPHLHATPGYHHITVVEAGRTAYLAGQCPLDASGKL
                     VGEGDLDAQIDQVAANALAALNAVGAGPEHVVRSVIYVVSDDVPVLGSAWRRLTSSVVG
                     PAFTTASTLLGVARLGFSGQLVEVDLTAALPH"
     misc_feature    15875..15889
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            complement(16338..16802)
                     /locus_tag="N7E53_RS01095"
     CDS             complement(16338..16802)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700030.1"
                     /locus_tag="N7E53_RS01095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_193466911.1"
                     /transl_table=11
                     /translation="MRAVKINDIVIRRAAGSDAAEVAEVWLRSFTAALPGVRRAHTDDE
                     VRAWIREVVVPGQETWVAAADGSVVATMVREGNDLDQLYVDPAWQGRGIGGRLVDVAKE
                     RSPSGLTLWTFQVNEAARRFYERHGFVARERTDGQRNEEREPDVRYEWRP"
     gene            <16926..17087
                     /locus_tag="N7E53_RS01100"
                     /pseudo=""
     CDS             <16926..17087
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641918.1"
                     /locus_tag="N7E53_RS01100"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="QPGQIMAAVALVRRVAEEGREVTEDDLDGIRNICRCGTYPRIREA
                     IRSAAGRM"
     gene            complement(17121..17678)
                     /locus_tag="N7E53_RS01105"
     CDS             complement(17121..17678)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132251.1"
                     /locus_tag="N7E53_RS01105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_037637687.1"
                     /transl_table=11
                     /translation="MLQTGSSVSTRESIHKAATRLFRSRGYSRTTVRQIAAEAGTDPAL
                     VIRHFKSKELLFLETMHLTLDDEPLLDVPLEHLGEGLAELLLDLGGSARGVFLALVHGS
                     NEPHIHDRLRDTHEHLFVEPLRRRLDGPDADVRARTAAAVAGGLLYALWVAGDQGLLRM
                     DRAELVSRYGALLQDVLTPRTS"
     gene            17954..18832
                     /locus_tag="N7E53_RS01110"
     CDS             17954..18832
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980729.1"
                     /locus_tag="N7E53_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_261674480.1"
                     /transl_table=11
                     /translation="MQKHVSRRNVMATSFALAGALALSLTAGGTAQASDPLQYVALGDS
                     YSAGSGVLPVDTSNLLCLRSTANYPHVIADRTGARLKDVTCGAAQTKDFTSSQYLGVPP
                     QVNALSADTDLVTLTIGGNDNGTFINAITSCGSAGLLTAGKGSPCKDKYGSKFADEIRN
                     NTYPALKNALNAVRAKAPNARVAVLGYPWITPEKADPSCYLKLPIASGDVPYLRDVQTH
                     LNAAVERASEETGATFVDFAEVSDGHDACTPLGTRWIEPLLFGTSLVPVHPNALGERRM
                     AEHTMEVLGLK"
     gene            complement(18957..19352)
                     /locus_tag="N7E53_RS01115"
     CDS             complement(18957..19352)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020392461.1"
                     /locus_tag="N7E53_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RidA family protein"
                     /protein_id="WP_093552335.1"
                     /transl_table=11
                     /translation="MERNAVNPVSWSVERGFNQGEVVSGHSRTLFISGQTAMSEDGKPE
                     HDGDMAAQLALSVDNVEAVLAEAGMSLANLVRLNVYTTDVDLLFRHYGVLAGRLGAAGV
                     APTTTMLGVTRLAIPGQMVELEGTAVA"
     gene            19468..20451
                     /locus_tag="N7E53_RS01120"
     CDS             19468..20451
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006349586.1"
                     /locus_tag="N7E53_RS01120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YafY family protein"
                     /protein_id="WP_203551479.1"
                     /transl_table=11
                     /translation="MRADRLVSLVLLLRQRGRMTAEALARELEVSTRTVLRDMEALSSA
                     GVPVYAERGRHGGFALLPDFRTALTGLTHDEALALLVAGSRRGAQLFGLGSALASAVLK
                     VVDALPDGLRETAAGAAQRLLVDPETDLLARPVAPEEVPDAVATQVRRAVFGGHRLRIH
                     YAAVNQLPRWRTVDPIGIVTVKDQGYLLARRGSEDRTYRLSRVLAAEQLDEPARRADSV
                     DLGRAWREREVRFRTGGDTTEVLVRADPARRERLAATALAVTGEGTDAEGRLRMTVVFQ
                     DARHAEWALWEHAPGAEVLAPEWLRTRLGERAREVARLYGDASPEP"
     gene            20495..21523
                     /locus_tag="N7E53_RS01125"
     CDS             20495..21523
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964313.1"
                     /locus_tag="N7E53_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S66 peptidase family protein"
                     /protein_id="WP_033274304.1"
                     /transl_table=11
                     /translation="MTVRYPSPLRPGDRVGVTSPSSGVPEALRARLEVALGDVRARGYE
                     VVVGRCMDGSGHVSASAAERADELMSMLTDPTVKAIVPPWGGETAIDLMPLLDWDRLRD
                     VEPTWVVGYSDMSTLITPLTLLTGTATLHGNNLMDTPYRVTEGLLSWFDIVAAPPGRSF
                     TQTPPGRHRTVGFDDFAAFPDVREYTLDTEGGWTRLDGEGDVEAEGRLIGGCVETLCNL
                     AGTPYLDVSAFTRDRAPEGLLVYVEVCDSDAFTVCRHLHGMKLAGFFEGANAVLVGRTG
                     APDSPSLTQHEAVLDALGSLGVPIVADVECGHVPPYMPIVNGAYGRVVHTAGRSALTQT
                     LR"
     gene            21556..22617
                     /locus_tag="N7E53_RS01130"
     CDS             21556..22617
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700031.1"
                     /locus_tag="N7E53_RS01130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_051724478.1"
                     /transl_table=11
                     /translation="MSRGARLAAHGAVSASLARHSDRELRELLHAGRPLGSGIGGERVL
                     LDVDGTPVFVKRVRLTDPERRPENLYSTRNLFELPLFCHYGVGAIGGPGFGAWRELAVH
                     RMATDWVVAGRYEGFPLLHHWRVLPDGGRPLPEELADVKRAVAYWGGGAEVRHRIEALQ
                     RSSASVLLFLEYLPWNLHDWLGERMAAGDEAAERACAMVDDELRAGIAFMNANGVLHFD
                     AHFENILTDGRRLFFSDFGLAFSSRFDLARAEAEFFEKHRVYDRCYAVTHLVNWLTVAL
                     LGHEPEERAAFVRACAEGARPTRMPASIADVVARYAPVAEVMGDFRHQFRTVSRTAPFP
                     FTAIRQRLEKCDQ"
     gene            22634..23170
                     /locus_tag="N7E53_RS01135"
     CDS             22634..23170
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048817.1"
                     /locus_tag="N7E53_RS01135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_033274306.1"
                     /transl_table=11
                     /translation="MDPVVPTPVADQLFGQVEIELDHEGGTLRVSGGGLPTVRIRRSPD
                     TEVATRVPIGTRDPARLTLLVDGVEETPRPAKGLLSRRSYRVEVVSATRDCRYVLVPNS
                     SDTSRLRRDKRRLGVFTSTGDGKVSAVWENGERRSTAAPEPYDAAVGYALAAAYGTGAE
                     PMWHEALDAVTELWP"
     misc_feature    22715..22717
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    22868..22870
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(23347..23361)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            23490..23978
                     /locus_tag="N7E53_RS01140"
     CDS             23490..23978
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123099.1"
                     /locus_tag="N7E53_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CbrC family protein"
                     /protein_id="WP_033274568.1"
                     /transl_table=11
                     /translation="MSDSLPHFRYHPDPVATGSIRASADRCVCCGRSRGWIYTATFYTA
                     CDVDGPFCPWCIADGSAAERFEGDFTDCYGLDDVSMDVVHEVTRRTPGFHGWQQPHWLT
                     HCGDAAALVGEVGHAELARHPEALAQLGDFAPHLGGDAAAVLFRCTVCGSHLAYADAS"
     gene            complement(23991..24371)
                     /locus_tag="N7E53_RS01145"
     CDS             complement(23991..24371)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521001.1"
                     /locus_tag="N7E53_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_037637698.1"
                     /transl_table=11
                     /translation="MGLMLFPGDGDVTSPDVEWTYSGFASFRGWLARIEGFTLDDMDGF
                     GGERPWSSVHTTLAPLLDHPDDHGELTPAQCAAILPRLEEVHDDHVADDSDPDVRQHVE
                     DVGRLITVLRICVAKDAELCFG"
ORIGIN
        1 ccccggcacg cgtcccggtc ccccgaaacc gctgccccct gccccttgca cgtccccgac
       61 ctgagcgtct cccgctcgta cacctcagga gcccacccat gcccgcagca gaaccaggtc
      121 tgcccgaaga gagctggcgc tggacggaac cgacgtggcg cggccacgtg gacgccgtgc
      181 gcgccggacg gcgtctcgtc ccggaccgct ggcccggcgg cgcccgtgcg gccgtcgccc
      241 tgtccttcga ctccgaccac gagacgatcc ccctccgtga cggcgagacc agcccgggac
      301 ggctggccca gggcgagtac ggcgcccgcg tcggcgcgcc gcgcatcttg cggctgctgg
      361 cgcagcacgg cgtccccgcc accttcttca tgcccgcggt gtcggccctg ctccaccccg
      421 aagaagcgcg cgcttacacg gaggacgggc acgagctggc ggtgcaggct ggatccacga
      481 gcggaacacg ctgctgggcc gcgaggacga gcgggagctg accgcgcggg ccctggacac
      541 gctcgacgcg ctgaccggcc gccgccccgt cggcatccgg actccgtcct gggacttctc
      601 cggctccacg ctcgccacga tgctggacct gggcttcggg tacgactcct cgctgatggc
      661 cgacgacgat ccgtacgaga tcgtcgccga gggacggccc accggtctgg tggagatccc
      721 cgtcgactgg atcagggacg acgcgccgta cttcacgatg gaccgcttcg gcgccgtccg
      781 cccccaacag ccgcccccgt gacgtggggg agatctggcg cgacgagttc gacgccgcct
      841 accgcgaggg cggggtgttc cagctcaccc tgcatcccca tgtcatcggt caccgctcgc
      901 gtctggtcgt gctgcgggaa ctgctcgacc acatcaaggc acaccacgac gtgtggttcg
      961 ccacccacgc ccagctcgcc gacaccgtcc gcaccgtgct cgacggcacc gccggcgccc
     1021 gtcccgtccc ctcggagcgc acgccatgaa cctgaagtcc gacctgtccc ccgggtcccc
     1081 cgcggcgggc ggcgcgtccg aaccgcagaa gctgaacgcg aagcagcgca aggccatcgt
     1141 cgcgggcacc atcggaaaca ccgtcgagtg ggtggactgg gccctctact cgatcttcgc
     1201 gaagatcatc gcggacgagt tcttccccaa gggcaacggc gcggtcgccc tgctgtcgac
     1261 gctcgccgtg ttcgccgtcg ggttcgtgat gcgtccggtc ggcgccgccg tgctcggcgc
     1321 gtacgccgac cggcacgggc gcaagaaggg catgacgctg accgtggcgc tgatggcggg
     1381 cgccggtttc gccatcgcag tcacgcccgg atacgagcac ataggggtgc tgtcaccgct
     1441 gctgctgctc gtcgcccgtc tcatgcaggg cttctccgcg ggcggggagt tcggttcgtc
     1501 gtccgccttc ctggtcgagt ccgcggcccg cggccgccgt gccttcgccg gatcgtggca
     1561 gcaggtgtcg gtcgccggcg gcgtgctgat cgcctccctg ctgggcaccc tgaccacgtc
     1621 cgcgctcagc gacgaggcgc tgcactcgtg gggctggcgc gtcgcgttcg tcttcggcgg
     1681 gctcctcggg ctggtgggcc tgtggctgcg ggtctccgtc gaggacaccg agtcgttcgc
     1741 ccgcagccag gacggcggcc ggacccgcac caaccccgtc aaggcgatgt tcgtcgagca
     1801 cccggcggcc acgctgcgcg tcgtcggcat cacgatcgcc ggcacgctca cgtactacat
     1861 ctgggtcaac tacctgccga cgtacgcgaa tctgacgacc ggcatcccgc tgaagaccgc
     1921 gctgctgtcg cagacgctgt gtctggtcgt gttcgtgatc gcgctgccgt tcgcggggct
     1981 gctgtccgac cggatcgggc gcaggccgac gatggcggcc ttcgccggcg ggttcgtcgt
     2041 gctggcctgg ccgctgctgc atctgctggg cgacagtttc tggtcgctgt tcccggtgca
     2101 gctcgtgggc atgctgctga tcctcggcta ctcgtccaac tgcgccgtca tcatggccga
     2161 gcagttcccc gccgaggtcc gcgccaccgg catcgccctg ccctacgcgc tcgccgtcgc
     2221 cgtcttcggc ggcaccgcgc cgtacgtcac gacgtggatg cacgagagcg gccacagcgg
     2281 cctgctgtgg atctacgtga gcgccgcctc gctgatctcc ctcgtcgtct acctcacgat
     2341 gcccgagacc aaggacaagg acttcacgtg acccacattc tcgtcaccgg ggccgcgggc
     2401 ggcatcggca gcgcgatcgc cgaggcgttc gccgcgcggg ccgcgttcct caccctgtcc
     2461 gaccgggacg tcgacgccct gcgcgccacg gccgcccgca tcgaggggag caccgcgatc
     2521 cgggcagccg acctgagcga ccccgacgcg gcgacggacc tcgtcgaaca gagctgggcg
     2581 gcgcacgggc cggtggacgt cctggtcaac gcggcgggtg tctacccctc cctcgacatg
     2641 gccgacgtcg acgcggagtc ctgggaccgg ctgttcgccg tcaacctgcg cgcccccgtc
     2701 ctggccacgg ccgcgctggc ccgcctcgcc gcggctgcgg gccggcccgc gtccgtcgtc
     2761 aacatctcct ccgggtccgc gctgcgctcc cgcccgggcg gcggccccta cgccagttcc
     2821 aaggcggccc tggagatggc gacgcgggcc gccgcgctcg aactgggcgc gctgggcatt
     2881 cgcgtcaacg cggtcagccc cggtttcgtc ctggtcgaca gcgacgtcaa cccggtgtcc
     2941 gccgagtacg ccaggagcat cgacgtcaat ccgctgggcc gccccgggac gcccgaggac
     3001 gtcgcccgcg cggtgtgctg gctcgcggga ccggaggcct cctggatcac cggtgagacc
     3061 gtacgcgtcg acggcgggtc gagcacgggg gcgctgcacc tgccgcggat ctggcaggcg
     3121 gacggcaccc gggcgactcg caccacgcac gcagaggcac cggtgggtgc cggcaccacg
     3181 acggaggaag ccacccgatg agcgacatca cccaggacgc ggccgcctac accgtcgtcg
     3241 gcggcggggc gatcggcggg accctcgcct tcgccctggc ccgcgcgggt cacccggtca
     3301 ccgtcgtgga cgccgacccg gcacacgtgg aggccatccg cacgcacggt ctcgtgctgg
     3361 cgcggagcga ccgccgtacg agcgtcccgg tgcgcgccgt gacgcccgac gccttcgacg
     3421 gcaggctcgg ccgggtcctg ctggcggtga aggcgcaggc cacccggggg gcggtcgagt
     3481 ggatcgcccc tcgcctggag cccgacggct acgtcgtctc cgtgcagaac ggcttcaacg
     3541 aggacctcat agcggagtac gtaggcatcg gccgtacggt cgcggcgttc gtcaacatct
     3601 tcgccgacgt cgtggagccg ggggtgatcc tggacggcgg cgcgggggcg ctggtgatcg
     3661 gcgagcccaa gggcgctccg gtcggggaac gcgtccggtc gctggtcgcc gacctgcaga
     3721 gctggggtcc ggcgcgggcg agcgacaacg tcgagggata tctgtgggcc aaggcgggct
     3781 tcggcgcgat gctcgcggcg accgctctcg cggacgctcc catggccgac ctgatcgacc
     3841 ggcaccggtc ggccatggcc gccctcacgg cggaggtctt cgcggtcgcc gaccggcgcg
     3901 gggtcacgct tcaggcgttc gacgccttcg acccggagcc gttccggcag ggtgcggatg
     3961 ccggagcgcg cgaggccgcc ttcgaccggc tgaccgcgtg gctgcgcacg cagagcaagg
     4021 accgcagcgg catctggcgt gacctggcgg tacggcaccg ccccgtggag gtcacgacgc
     4081 actaccgcga cgtcatcgcg tacgccacgg aactgggcct gcccacgacg ctgctgcgca
     4141 cggtgatgga cgggctgcgt gagctggagg gcgcgccgga gacgatgtcc gaggggcgtc
     4201 tcgacgcgct ggaccggctg accgggccga acctcgacga cgtggacccg ggcgttcggg
     4261 tgcggcgctg gctggaggag caccgcgagg agatggtcgc cgatctggcc gcgtacaccg
     4321 cgcggggcag tgcgagcgac gacctcgacg cgctggacgc gtgcctcgcc tggctgcgcg
     4381 gctggctcga cgagcggctg ggcgcggcgg agagcgagga gatcctcggg cgtgaggacg
     4441 ccggggacgt cctggtccgc cgctacccgg cgcgggacgc cacgacggcg gacgcgcggc
     4501 cggtgctgct gctcgggcac tacgacaccg tgtggcccac cggcacgctg gagtcgtggc
     4561 cgttccgccg cgacggcgac accgtcaccg ggcccggtgt cttcgacatg aaggcgggcc
     4621 tggtccaggc ggtgtgggcc ctgcgcgccc tcgacgccct cgggctgccc cgcccggccg
     4681 tcaccctcat gctcaacggc gacgaggaga cggggagcct cgcctcccgc gacgcgatcg
     4741 tggagacggg gcgggactgc cggctggcca tggtgttcga agcggcggtg gacggggcga
     4801 tcaagacggc ccgcaagggc gtgggcctgt tcacgctgac ggtcaccggc agcgaggcgc
     4861 acgcgggtct ggacccgacg gccggcgcga gcgcggtcga cgaactcgct taccagatac
     4921 tccggttggc ggaactgcgg gacctggagg cgggcacctc cctcaacgtc ggcgtgatcg
     4981 agggcggcac ccgcggcaac gtcacggcgg ggcgcgcctc ggcgcacctg gacgtccggg
     5041 tggccagtgc cgcggagcag gaccgcatca cgcgggcgct cgcggacctg cgccccgtgg
     5101 acccggggac gcggctggag gtcacgggcg actggaaccg tcccgtcttc gaacgcggcg
     5161 aacaggtcgc atgggcggcc gggctggcga aggacgcggc gcgccggctc ggacatgacc
     5221 tcacggaggc ggcggtcggc ggggcgagcg acggcaactt cctcgccgcc gcgggtgtgc
     5281 cggtgctgga cggcatcggg gcggtcgggc acggagcgca cgcgcggacg gagtgcacgt
     5341 cggtcgcggg catggtgttc cggtcggcgc tgacgggcgg ggtgctggtg cggctcgccg
     5401 gggagtgagc cgggcgtagc cgctgcggca cgccgcctgg accatgaccc tggggccacc
     5461 cccaggcctg gcgtccaccg actggtggac gccaggttca accggatgcc tctgtccggc
     5521 aactgccctg gccagccagg cttttcggca tgaagacaat ctctgtgcgc atggcgcgct
     5581 ggagcgcaca tcacccttgg cgggccatcg ccggctggct ggtgttcgtg gtgctctgcc
     5641 tggctgtagg cgccgcactc gggaccaaca gtgcgaagac ggcggactac cgggtcggtg
     5701 aggccggacg cgccgaggcg cttcgccggg agcggcacct ctgcgggaga cggcacctgt
     5761 gcgggaccgc gtcggcctca gctctcgccg tgtccggtga gccaggccag ggcctgcgcg
     5821 cgctcagcct cggacggggg cggtttcagc cggtccgagt agcggatcag ggcgtggtcg
     5881 cgggccgccc gcaggccgat cgcgcgacct tccgaggaga gccgggtgtc ctcggcgacc
     5941 tcccgggcgc gctgccacca gctccggctg ctggacttca cggcgtagtg ccagagcggc
     6001 tgcgcggggt cggccacgcc cagcagcacc cggtggagca cgcggtcgcg gatacccggc
     6061 gcgccgatca ggcggtcggc cacgaggagc ggatgctcgc cgtcgaggcg cgcccggacc
     6121 aggacgtacg tcatcagctg gcccacgtcg tgggcggacg aggtgacgaa gtcccacagc
     6181 tccgcggcct tggtctcgtc gggggcgccg aggtgcgtga gcagccggag cttgtccttc
     6241 cagacaggcc gggcccggtt ccaccaggag accagccgtc ccgcctccgg gtggtccagg
     6301 tcgagggcga ggcaggtcag tgtcaccagc gggtggcgcc actccgtgta cgtggtctcg
     6361 tacttcttgg tgaggtcctt caggcggtgg ggcaggagcg cctcgatctc gtgcctgccg
     6421 gcgaggccgt gggagtggag gagttcgagg cagaagccga gtccttggag gccggtcccc
     6481 gggtccgcga cccgttcgcg gagccagtgt gcgtccgcgt cggtgagggt gcggtagtgg
     6541 tgccacacgg cgcacagcgc gccctcgtag gtgtcgaggt cggggccggt ggcggacgac
     6601 agggcgtcgc gggcggcctc gtagcggtcg agggcggcca gcgcttcgga ctgttcggtg
     6661 tcggtgagca cggcggagcc tggccgaagt gcttcctcgc ggacgagttc cgcccggtcg
     6721 cgggcggcgg ccgcggcgag gacgcgcagg gcgtgcggga ggcgttcgtc ggtggagaac
     6781 cggaccgccg cgaggccggc atgcaggtcg acggagccgg gaccggcgcc cgtgtcacgg
     6841 cgccggtcgg tcacggcagc gccgatcagc gcttcgtaca gcccgcgtag tgagctctcc
     6901 gaagcgccgt gcgcggtcag ttcggcggcg agggcggacg cggctcgtac ggcgtcgggc
     6961 tcgtggagtg agcggtgcag cgacagccac gcgcggagcg caccgcggtc gcctgcgagc
     7021 gcggcctcac ggacgacgcg cagcccttgt gcggtgggca cgtcggacag gacgccgtac
     7081 gcccggaggc cgtacacggc gacgatgtcc cacgcggcgg cgtggccgtg gcgcagcagg
     7141 gcgtggagca cggcggaccc ggcgttccac tccgtcagcc gtccggcgta ctcggcctgc
     7201 caggcgtgca gcagtcgctc ggtctcgtcg gcggtgagtt cgtcccgctg ctccagcggg
     7261 atcgcgaagc gcgccgcggc ggagacgtcg ggggcctcgt cgaggcgggc gtggagccag
     7321 gcggcctccg ccggggacag cgggccgtac gtgaggcggg gcgcagcgcg gtccacgggt
     7381 tcgccgagca tgctgaggaa ctggcggacg ccgtcggggt ccgacgggtc cggcagcccg
     7441 tcgtcgtccc ggtgggtgat ccggtccagc cggaacgcgg acctgggtcc gccgtcgacg
     7501 atgccgaagc ccggcggtcc ttcaccgagc ccggcggcga cggtggcgtg gtcgccgccc
     7561 cagtgaagca gcagttcgcc tgtcagcgtg ccggagcggt cgaaggcgtt cctgtgggcg
     7621 tcccagtgcc agtaggcgaa ggaggcgggg cgggtggtgt cggtggcggt gccgcccctg
     7681 ccgcccctgg ccgcgaggag gagggcggcc tcctcgtgac cgtcggcctg ggtgaagcgg
     7741 cgtcgggtcg gcggcggcag gacgaagaag ccgttgcagg caaggccgtt ccaccacgtg
     7801 gtgacggcgg cgaggtccga cgacggacgc gggctgttca cgagctcccc cagcggttcc
     7861 ccctggccgg acgacgctcg gctcagggtc ggcgttcggc ctcaccttgc catacggcgt
     7921 cgccccgtag ggtgtcggag cacggtgtgg aacggacggg gaggtacgcg tggcgcgggg
     7981 gaccgtgagg ggacaccggg tcgtcggtgc cgggctggtg ctgttgctcg cgtcggccgg
     8041 ctgcggctcg ccggccggcg acagcggtga cggcggggcg accgccgctc cgccggtcag
     8101 ggacaagggg ccggtgtgtg tcggtgaggc gccggccgac ggggtgcggg tgctgcgagg
     8161 cggtggcttc cggctgccgg gcgggacggg tgtgcagtac gcgggggcgt cggcggacgg
     8221 cagcagccgc acggcgacgc tgcgcgaggg cgcccggtac gaggaggggc agcgcgagtg
     8281 gaaggtcgcg gtgggggcgc gggttccgct cgccggtcac gcgtacacgg tgcggcaggt
     8341 gtgctcctac cgtgtcgtgc tggaagcggc ctcggcgcgg gacgcgtcgg cgttggccga
     8401 ggctcccgcg tcgatgacgt cgacgggtgg ggaggccgac gcgggtctgt gcttcaccac
     8461 caaccgtgcc gtgctcaagg cggcggccga cggatccccc gccgagggtg agagcctgtc
     8521 cctggtcggc aacggcgggg tccggcgctt ccccacgggg ctgtcgctca ccgtgtccta
     8581 cctggacgcg gaggcgggga cggcgggcat cgcggcgaac tgcgcggccg tgccggtcgc
     8641 ggcgtacgag gagttgcgtg tcggtgatcc gctcgaactg gggggtgttc tcttcgaggt
     8701 caccgacgtc acggaggcgg tggtgcggct gacccgtccg gccgcgccac gcccctgaac
     8761 gccgtggtca cgctgtcggg tcggcttgct ccccggcctt cagcagtctg cggcgccgca
     8821 cgacgaggaa gacggcgccg ctgagcagca acggggtgag gacggcggtg acgagcatgg
     8881 ggagcgtggc ggtgggcggg tcctcgaccc agcgggtcgt cagcacccgc gtcggttccc
     8941 gagggtcgta ggtcaccggg accgcggctc cggcccggag gccctcgggg cgtttgcctc
     9001 cccagtcgtg cagctcggtc tcgaccgtgc cgtcgggacc gtcgaagcgc accttgacgt
     9061 tgcccgcgtc gccgtacttg ttcttcgacg cggcggtgac ctcggccacc acggatatgc
     9121 ctcgtgaccg taggtcgttc accagcgacc ggccggggag gaggaacatg aggaaggccg
     9181 tgagggtgac cagggccaga ccgaacaggg tggcgatcaa gcgcttctga ggcagaggcg
     9241 gtcggttcgg cgcagccctg gacctacgcc actcctcctc ggcggcccgc ctctccgccg
     9301 acaggggcgg acgcgtccag ttctcgcgac gcggccgtcg cttcttcttc ttgcccacgg
     9361 ggagcggctc cttcttctgc acgagcgggc ccctgtacac aaggaccgca acccgccaac
     9421 tgtcggggac gagttcggat catgacggac gactggcgga aagaccgtat cggtgctgcg
     9481 ccgcgcgggg acaacccgac cgtgacgcga aggcccgacg ccggcttcgc ggcgatcggt
     9541 gacgtccggt cgagggcggc catcggcgac ggacccggct tgctgcgggc gccggagtga
     9601 gtaggaaggc cgccctcctc ttaccgtgat caatggcttg atttcaccta ccacctatct
     9661 gcggcagccg cgaaggatac gcatgccgag ccaccacagc ggcccggcgc gttcgagtcc
     9721 gtgcaccccc aacacccgag ggagaagcat gcgtaccgag atcgttctgt cccaggatgc
     9781 ccccgagctg gacctcgacc tggacctccg tgtgtccgac ctgccggagc aggccgagtc
     9841 gttcgggcag ggcacctaca cctcgccgag cagctacgcg atcggcacgc gctgccctgt
     9901 ctgctgctga cgggttgaag cccctcaggg gctcttccga gcggggcggt gccggaaccg
     9961 ccccgctctt ccgtacgacg gcgacgagga gagcacacac gtggcggcgg agtgcgaagc
    10021 cgggcaggcg tctgcagcat tcgaagtgag ggatcccgta ctcgtccgca tggcgagccg
    10081 gccacgcggc accgacctgg aaggcgtcga cgccgccgat ccggtgcccg gggcacggcg
    10141 gctcgccgcc gacccggtgc tcggccaggc ggtgcgggtg gccagcggct ccctggcgca
    10201 cagcctggac cgtctgaccg gtgacgaggg tgtggccgcg ctggggcgca agcggacgct
    10261 gagcgccgcg cgcaccctga cgcggtacgc ccgccgggcc gcggcccgtc cgacgccgtt
    10321 cggtctgttc gccggcgtcg gcagggcccg cttcggttcc gcggccaagg cggaaccggg
    10381 ggccggtgag gtcgcggtcc ggctggacgg ggcgtggctg cggcggcgcg tgatggcctg
    10441 gctcgccgag ccgtccgtac gccggcgcgt ggacgtcgtg ctcaacgacc tgtgcttcgt
    10501 gcgcgacggg cggctgtgtc tgcgcaccgg cggacaagag cggtcggtgc gggacaacgc
    10561 gctggtgggc gcggtgcggg agcggacgcg gaccctggtg gggtacggcg acctgctcga
    10621 taccctcacc cggcgattcc cctcgctgga tgccgagcgg ctcgacgggc agctcgccga
    10681 gctcgtccgg cgcggcttcc tcctcacctc cctcaccccg caccggatcg acaccgcgct
    10741 gctcgacggc atcgaggcgg tgctcgacga ggcgcttccc gacgacgcgc gggcgttgcg
    10801 ggacatccgg gcggcctgtg cgcggcatga gcgggactcc ccggaggcgg gcggcgaatc
    10861 ctggcaccgg ctgctggacg aggtgcggcg tctcgacgtg cccggcacgg acggtgacgc
    10921 gcaggcccgg cctcccgtgc acgtggacct gcacatgcgc ggcgagttcg tcctcccgga
    10981 gaccgtcggg cgtgaggtgt gccggtacgc gggcgcgatc tggtcggtca ctccggagtg
    11041 gacgacgctg gcgtacatgc gggactaccg cgaccgcttc atcgaacgct acggcaccgc
    11101 ctgcgccgtg cccctgggcg agctggccga cccgcaccgc gggctcggtc tgcctcccga
    11161 gtacggcgcg gagcccacgt acgcgcgcac cggcccgggt gacgaggtgg acggtccgcg
    11221 gcgggcgttc gtcggtgagc tgatccagga ggccgtcctg tccggcggcg acctggtgct
    11281 gaccgacgag gtcgtacggc gtctcgcgga cgtcgcccgg cacgatccgg aggccgcgcc
    11341 gccacgcggc ctcgaactct gcttccaggt gctcgccgac agcaccgccg ccctggaccg
    11401 cggcgacttc cgcctgctcg gcagcccgca catcggggcc tgggcggcag gcgcgaccgc
    11461 ggggcgcttc gcggaggccg ccggtctcac cgcggacctg acccggctgg ccgccgagac
    11521 ctcgggcgat cccgacggcg acgtgatcgc ggcgcaggtg gaactgctcc cccgtgaacc
    11581 gcgcgggctc aacatcgtcc aggtgccccg gctgctgccg taccgcatcc ccgtcggtgt
    11641 gcccgacgac cgggacgacc cccgctgtct ggactggcgc accctgctcg tcgccgccgg
    11701 ttcggacggg ctgcggctgc tgcacccgga gagcgggcgc cctgtccggc cggtgctccc
    11761 gcacatgctg gccctggacg cgcaggcccc gccggtggcg cggttcctga tggatctggc
    11821 gacggcacgg ccgcgggtgt ggtcgggctg ggactgggcc gggcacgaca ccctgccgta
    11881 tctgccgcgc gtgcggtacg gccgggtggt cgtgatgccg aagcggtggc tgcccgggcg
    11941 ccggctgcgc gatgcggcgc gcgccaaggg cgccgaggta tgggaggagg gcctcgacgc
    12001 gtggcggcgg cgtctcaccg taccggaccg gctgcacatc gcgcgcaacg accagatgta
    12061 ccccgtcgac ctgcgcgacc ggtgggacag ggagctgctg cgctccgaac tgaccgccct
    12121 gcacccccag ttcgtcctct acgaagatct gaccaccgac ggcgcggggc tcggctggaa
    12181 cggcgggcac agcacggaga tcgtggtgcc cctcgccggg gcgcggccgt ccggcggggc
    12241 cacggggacg gggagccggg ggcaggcgcg aaccgcgccg ccggtccggc tggctcccac
    12301 ccggttccat ctgccgggcg aggactggct gttcgccaag tggtacgcgg agccgtcggc
    12361 ccacgaagcg ctgctcgcgg atcaccttcc cgccgtgctc ggcgagatcg aggacgacgt
    12421 cgaccgctgg ttcttcgtgc ggtaccagga ccccgacccg catctgcggc tgcgcttcca
    12481 cggcgacgtg gaggcgttga acggccgggt gctgcccgcg ctcagccgtg cgtcccgcgt
    12541 actcgtcgag agtggtgcgc tgcgttcgat gactctggac acctaccggc ccgagagcga
    12601 ccggtacggg ggcgaggccc tccaggaggc ggccgagcgt ctcttccgga cggacagcct
    12661 gtcggcggtc gtgcacctgc gtgcggcgcg cggcgcggcg cggggcctgc ccgccgacgt
    12721 cctcgccggg ctcggacacg cggtgcttct cgagtccctc ggggactggg actggtgcgg
    12781 ctgggtcgac cggatgttca ccaagtccga ggagcacgag gtctaccaac ggcagcgtgc
    12841 cctcgccgac cggctgatca cgccggggaa cgtggtcgcg tccgccgtgg aagcgctcgg
    12901 agcgcccgcg ctccgctcgc tgtgggccga ctccgacgag ccgcgtgcgt acgggcgggc
    12961 ggtcctctcc gccccggagg ccgaccggga cgaggcgctg ctgtctctgc tgcacatgcg
    13021 gcacaaccgt cacttcggca tcgaccggtc ggcggaggct cgcggatacg cggtgctgcg
    13081 gggtgcggta cggagtcatc tcgggcgaca gcggcatcgc ggtgaccacg gcaacgggaa
    13141 cgggagcggt cgatgagcgg ggcggcggac gtgagcgcca agggcggaga ggctcgcgag
    13201 cgtgcggacg gtgccgccac ccggggactg cgtgagcggg ccggtgccgt gtccgccgcg
    13261 atcctggaac ggctggccga tcccgccgcc accgtggcgg ccacccgcat cccgtccgag
    13321 gccgccgacg acggggtcgc cgagccggtc tgggcggagc tgaccctcgg cagcggaagt
    13381 ccgggactgg cgctcgcctt cgccggggcc gcccgggacc cggagcggca ggtcccgcgc
    13441 gcccatgcgt acctcacggc gggcacgcgc gccgtctccg gtgggccagg cgccgcgagc
    13501 gggatcttca aggggcccgg cgccctcgcg ttcgccgtgc tggtcgctca ccgcaccacc
    13561 ggcgggtacg tgtccgcgct cggccgcttc gacgcctacc agcgcgatct cgtacggacc
    13621 gtcctgccgc cggtcgagga ccggcccctg tcgaccatcg ggcactacga ggtggtgcgt
    13681 ggactgaccg gtgtgggccg ctatctgctg gcgcgtgcgg agacctgcga ggagccgctg
    13741 accgcggtgc tcgaccacct cgtgcgtctg tcggtgggca ccgtggagca tcagggggca
    13801 cgggtgccgc gctggtgggc gctggacgcg ccgcggaccg gctcggagga ggcgttcccc
    13861 ggtggtcatc tcaacctcgg cctgtcgcac ggcgtcgcgg gaccgctcgc gttgatggcc
    13921 ctggcatggg agcagggcgt gcgggtgccg gggcagcagg aggcgatgga ggccacggcc
    13981 ggcctgctgc gcgcctgggc ggtgacggac cggcacggtg tcttctggcc cggccacctc
    14041 tccttcgcag agtggcggcg cggtcccgcc gcgtacgacg gcagggccaa gtggccggcc
    14101 tggtgctacg gggctcccgg ggtgtcccgc gcgctgcaac tggcggggcg ggccctcggc
    14161 cggagcgacc tctccgacct ggcccgcgcc tcggtggacc ggctcctcgc cctcccccgg
    14221 tcggactggg ggatcaacga ccatgcgctg tgccacggtt gggccggagc cctgcaccag
    14281 ctcggccggc tcgacgagga gtggcgggac ccgcggctgg cccggctgcg ggacgacatc
    14341 gcctccgaac tcgtcaccgc cttcgacccg gcgctgccgt tcggactgcg gttcaccatg
    14401 accaaggtgc cgttcggctc cgacgtgtcc ggttatctgg acggcgcggc gggggtcgcg
    14461 ctcgcgctcg actcgtacgc ggtggacggc acgccggccg actgggacat gccgttgctg
    14521 ctggcctgac cacgagttgt ccacgtgtcc atgtggctgg caccagttcc cggcggggcg
    14581 ttcgccggat gggcggtggc ccccggtcct cctagcctcg gagcatgatc actcgtcgac
    14641 gcctcctgat gtcaactgcg gccgctgcgg tggccggcac ggccgtaccg gcggcagcgg
    14701 ccacggctcg gtcaccctca cggtcactgc agcgtgacgc cgacgcgctg cgggacgccg
    14761 gggtgaccgg ggtggccgtc cgcctggaca ccccgcacgg gacggtcacg gcccggtcgg
    14821 gcgtgaggga cctacggtcc ctcggcccgg tgccggaggg tgggtacctc cgtctgggca
    14881 gcacgacgaa gacgttcgtc gccaccgtgc tgctgcgact ggtgggcgag cgccgggtct
    14941 ctctggacca gacggtggac gatctgttgc cggcggtcgt acagggcgcg gggaacgacg
    15001 gccggaccat caccgtccgc catctgctgc ggcacaccag tggtctcccc gactacgtcc
    15061 ccgacgtctt ccccgagcag agcgccgaga cctacttcgc ccgccggtgg cgcgcgtacg
    15121 aggccgagga gctggtgcgc ctcgccgtgc gtcaccggcc caccttcccg gccgggacgg
    15181 ggtgggcgta ctccaacacc aactacgtgc tggccgggct gatcatcgag cggatcaccg
    15241 gacgcgggtg ggagcgggag gtcgccgacc gcattctccg cccgctcgga ctacggcaca
    15301 ccgacacccc cggcacccgg cccttccttc cgcacccgca cacgtccaac taccagcagt
    15361 tcaccgaggg cggcccgctg gtcgacacca cactccccta ccgtcccttc gacagcgggg
    15421 cggacgggtc gatgaccggc acggcacggg acctcaaccg cttcttctcc gcgctggcgg
    15481 gcgggcggct gctcgcgccc gccgaactga acgcgatgcg ggacaccgtg gaggtgccgc
    15541 cgggcaacgg gcaccccgtc ggggcgcggg cggggctggg gctgttccac acgcccttgt
    15601 ccggtggggg cggctgtctg ggacacagcg gaagcggatt cgggtacgtc gtcgagacgg
    15661 cgacgaccct ggacggccgg cgcaccgtca ctgtgtccgc gcacagccgt tcggccgatc
    15721 cggagcaggc ggcacgccag gagaccgcac tgcgtgacct catcgaccac gctctgagcc
    15781 gcggcgactg agacaccggc agcaggacag gcgggcggaa aaggtgatgc gccgaggccg
    15841 ccaggtcgtc agaatcacgc gcatgaccgc cgagatcaca cgcatcaatc cgccgcacct
    15901 ccatgcgact ccgggatacc accacatcac cgtcgtggag gcgggccgga cggcttacct
    15961 ggcggggcag tgcccgctcg acgcgtcggg gaagctcgtg ggcgagggtg acctggacgc
    16021 ccagatcgac caggtggccg ccaacgccct cgcggccctg aacgcggtgg gcgccgggcc
    16081 ggaacacgtc gtccgctccg tgatctacgt cgtcagcgac gacgtgccgg tcctgggctc
    16141 cgcctggcga cgcctgacct cgtcggtcgt gggaccggcg ttcaccaccg cgagcacgct
    16201 gctcggcgtc gcccggctcg gcttctcggg gcagctcgtc gaggtcgacc tgacggcggc
    16261 tctgccccac tgaccgggac gcccggacgt cccgtggctg aacagcccgg agtgaggtgc
    16321 gtcggcgccc tggccggtca ggggcgccac tcgtagcgga cgtccggctc gcgctcctcg
    16381 ttgcgctgac cgtcggtccg ctcccgggcc acgaagccgt gccgctcgta gaagcgccgc
    16441 gccgcctcgt tgacctggaa cgtccagagc gtcagccctg acggactgcg ttccttcgcc
    16501 acgtccacga ggcgtccgcc gatccccctg ccctgccatg ccgggtcgac gtagagctgg
    16561 tccaggtcgt ttccttcccg caccatcgtc gcgacgaccg agccgtccgc cgccgccacc
    16621 cacgtctcct ggccgggcac gaccacctcg cggatccagg cccgcacctc gtcgtccgta
    16681 tgcgcccggc gcacgcccgg aagcgccgcc gtgaaggacc gcagccacac ctcggccacc
    16741 tccgccgcgt cggagccggc cgcacggcga atgacgatgt cgttgatctt cacggcccgc
    16801 atgctcgcag atctccgctg ccggccgcac cggatttccc tcccacgccc tcggcgctcc
    16861 cgtcagtttt cgccgcgcac cacggatccg cccggcgccg cccccttgcg ggatcaggct
    16921 actgacagcc ggggcagatc atggccgcgg tcgcgctggt ccgccgggtc gcggaggagg
    16981 gcagggaggt gacggaggac gacctggacg gcatccggaa catctgccgc tgcggtacgt
    17041 atccgcggat ccgcgaggcg atcaggtccg cggccgggag gatgtgagcg gcagaggccg
    17101 ggcggtcccc gggccgtcgg tcaggaggtc cggggagtca gcacgtcttg gaggagggcg
    17161 ccgtaccgcg agaccagctc cgcgcggtcc atgcggagca ggccctggtc cccggccacc
    17221 cacagggcgt agaggagtcc tcccgccacg gctgccgccg tgcgcgcgcg gacgtcggcg
    17281 tcggggccgt cgaggcggcg gcgcaggggc tcgacgaaga gatgttcgtg tgtgtccctc
    17341 agccggtcgt ggatgtgcgg ctcgttgctg ccgtgaacca gcgcgaggaa gacgccgcgt
    17401 gcggagccgc cgaggtcgag gagaagttcg gcgaggcctt cgcccaggtg ctccaggggt
    17461 acgtcgagca gcggctcgtc gtcgagcgtc aggtgcatcg tctccaggaa cagcagttcc
    17521 ttgctcttga agtgacggat caccagagcg gggtccgtgc cggcctcggc ggcgatctga
    17581 cggacggtgg tccgtgagta gcccctgctc cggaagagcc gggtggcggc cttgtggatg
    17641 gactcgcggg tcgacacgct ggagccggtc tgcagcatgc gggccaggat aggcgtccgc
    17701 gcgcttcgca actgcgcgtt cacgcgttca cggcagccgg acgcagattg cgtgcgtgtt
    17761 tcaagaagtt cggtcaacaa tgttgactcc cgctcggggc ggctgcacat tacttgacgg
    17821 tagaaccaat cggtaaccgc tcgaccaggc actcttcccc gcctccgacc gccccgcccg
    17881 ttccatcggc acaccctgcc gccctgccgc cctccgcacc cgcagccccg ccctcccctc
    17941 ggaaagggat cacatgcaga agcatgtctc gcgccgcaat gtcatggcca cctcattcgc
    18001 actcgccggc gcgctcgccc tgagcctcac ggccggcggc acggcccagg cgtccgaccc
    18061 gttgcagtac gtcgccctcg gcgacagcta cagcgccggc tccggtgtcc tgcccgtgga
    18121 cacgagtaac ctgctctgcc tgcggtccac cgcgaactac ccgcacgtca tcgcggaccg
    18181 gacgggcgcc cgcctcaagg acgtgacctg cggtgcggcc cagacgaagg acttcacctc
    18241 gtcgcagtac ctgggcgtcc cgccccaggt gaacgcgctc agcgccgaca cggatctggt
    18301 gacgctgacg atcggcggca acgacaacgg caccttcatc aacgccatca cgtcctgcgg
    18361 cagcgcgggg ctgctgaccg ccggcaaggg cagcccgtgc aaggacaagt acggctcgaa
    18421 gttcgcggac gagatcagga acaacaccta cccggcgctg aagaacgccc tgaacgcggt
    18481 gcgcgccaag gcgcccaacg cccgtgtcgc tgtgctcggt tacccctgga tcacccccga
    18541 gaaggccgac ccgtcctgct acctgaagct gccgatcgcc tccggtgacg tgccgtacct
    18601 gcgggacgtg cagacccacc tgaacgcggc ggtcgaacgc gccagcgagg agacgggcgc
    18661 caccttcgtc gacttcgccg aggtctccga cggccatgac gcctgcacac cgctcggcac
    18721 ccgctggatc gaaccgctgc tcttcggcac gagcctggtg cccgtccacc cgaacgccct
    18781 cggggagcgg cggatggccg agcacacgat ggaggtactc ggcctgaagt agggcgccct
    18841 cacgacaccc tcggcgagcg gtccggtcac cgatcgtcgc cgggagccag gtgatgaaca
    18901 acgcctgtgg cggcggccgg agttcgcttc ggaccgccgc cgcaggtcaa ggagcgctac
    18961 gcgacagccg tcccttcgag ttccaccatc tgaccgggaa tggccaggcg ggtcacgccc
    19021 agcatggtgg tggtcggcgc cacgccggcg gcgccgagac ggcccgccag gacgccgtag
    19081 tgccggaaca gcaggtcgac gtcggtcgtg tagacgttca gccggacgag gttcgccagc
    19141 gacatgccgg cctcggcgag caccgcctcg acgttgtcga cgctcagcgc caactgggcc
    19201 gccatgtcac cgtcgtgctc gggcttgccg tcctcgctca tcgcggtctg gccggagatg
    19261 aagagggtgc gggaatgccc ggagacgacc tctccctggt tgaagcccct ctcgaccgac
    19321 cacgacacgg ggttgaccgc gttacgttcc atcaccgcat ctgctccatc cgtcaacgtg
    19381 tgggttggca ctgcctcgac gtcgtgcggt gaaccctcgc aggaaaacgt gacatctccg
    19441 gtcacgtatt tcgttagggt ctttcccatg cgagccgacc gtctggtgtc cctcgtgctc
    19501 ctgctgcgtc aacggggccg gatgaccgcg gaggcactcg cccgcgagct ggaggtgtcc
    19561 acccggaccg tgctgcggga catggaggcc ctgtcctcgg cgggcgtccc ggtgtacgcg
    19621 gagcgcggcc ggcacggcgg gttcgcgctg ctgccggact tccgcacggc gctcaccgga
    19681 ctgacccacg acgaggcgct cgccctcctc gtcgccggat cgcggcgcgg ggcgcagctg
    19741 ttcggcctcg ggtcggcgct cgcctctgcc gtgctgaagg tggtcgacgc gcttcccgac
    19801 ggcttgcggg agaccgccgc gggcgcggcg cagcggctgc tggtcgaccc ggagacggac
    19861 ctgctggccc ggccggtggc cccggaggag gtgcccgacg cggtggcgac gcaggtgcgg
    19921 cgggcggtct tcggcgggca ccggctgcgc atccactacg cggcggtgaa ccagctcccg
    19981 aggtggcgca ccgtggaccc gatcggcatc gtcaccgtca aggaccaggg ctacctgctc
    20041 gcccggcggg ggtcggagga ccgtacgtac cggctgtccc gcgtgctggc ggccgagcag
    20101 ctcgacgaac cggcccggcg cgcggactcc gtcgacctgg gccgcgcctg gcgggagcgg
    20161 gaggtgcggt tccgtacggg cggtgacacc acggaggtgc tggttcgggc ggatccggca
    20221 cgccgggagc ggctggccgc cacggctctg gcggtgaccg gcgaggggac ggacgcggaa
    20281 ggccggcttc ggatgacggt cgtcttccag gacgctcggc atgcggaatg ggctctgtgg
    20341 gagcacgctc cgggggcgga ggtgctggct ccggagtggt tgcggacgcg gctgggtgag
    20401 cgggcgcggg aggtggcacg gctctacggc gacgcgtcgc cggagccctg aaacccgctg
    20461 tccttccccc gccggccgtg ccaagatccc ccgcatgaca gtgcgctacc cctctcccct
    20521 gcgtcccggt gaccgtgtcg gtgtgacctc tccgtcgagc ggagtaccgg aggcactgcg
    20581 cgcacgactc gaggtggccc tcggtgacgt ccgcgcccgg gggtacgagg tcgtcgtcgg
    20641 acggtgcatg gacggttcgg ggcacgtcag cgcctcggcc gccgagcgtg cggacgagct
    20701 catgtcgatg ctgaccgacc ccaccgtcaa ggcgatcgtg ccgccgtggg gcggggagac
    20761 ggcgatcgac ctgatgccgc tgctggactg ggaccggctg cgggacgtgg aacccacgtg
    20821 ggtcgtcggg tactccgaca tgtcgaccct gatcacgccg ctcacgctgc tcaccggcac
    20881 ggcgaccctg cacgggaaca acctgatgga cacgccgtac cgcgtgacgg aggggctgtt
    20941 gtcgtggttc gacatcgtgg ccgcgccgcc gggtcggtcc ttcacgcaga caccgcccgg
    21001 acgccaccgc accgtcggtt tcgacgactt cgccgcgttc cccgacgtac gggagtacac
    21061 gctcgacacg gagggcggct ggacgcggct ggacggcgaa ggggacgtgg aggcggaggg
    21121 caggctgatc ggcggttgtg tcgagacgct gtgcaacctc gcgggcacgc cctacctcga
    21181 cgtgtcggcg ttcacccgtg acagggcgcc cgaagggctg ctcgtgtacg tcgaggtgtg
    21241 tgacagcgac gcgttcaccg tctgccgtca tctgcacggg atgaagctcg ccgggttctt
    21301 cgagggtgcg aacgcggtgc tggtcggccg gacgggcgcg ccggacagtc cgtccctcac
    21361 ccagcacgag gccgtcctcg acgcgctcgg ttccctcggt gtgccgatcg tcgccgacgt
    21421 ggagtgcggg cacgtcccgc cgtacatgcc gatcgtcaac ggcgcgtacg ggcgtgtggt
    21481 gcacacggcg ggacgcagcg cgttgacgca gacgttgcgg tgagggggcg ggaggcgaac
    21541 aaggagcgcg gtggcctgtc gcgtggtgcg cgcctcgccg cgcacggtgc cgtatccgcc
    21601 tcactggccc ggcacagtga ccgggagcta cgtgaactgc ttcacgcggg acgtccgttg
    21661 gggtcgggca tcggcggtga gcgggtgctg ctggacgtcg acggtacgcc ggtcttcgtc
    21721 aagcgggtac gactgaccga tccggagcgg cggccggaga atctgtactc cacgcggaac
    21781 ctcttcgagc tgccgctctt ctgtcactac ggggtcggcg cgatcggcgg cccgggcttc
    21841 ggtgcctgga gggagctggc cgtacaccgc atggcgacgg actgggtggt cgcggggcgg
    21901 tacgagggct tcccgctgct gcaccactgg cgggtgctgc cggacggcgg ccggccactc
    21961 cctgaggaac tggccgacgt gaaacgggcc gtggcctact ggggaggcgg ggcggaggta
    22021 cggcaccgca tcgaggcgct gcagcggtcc tcggcgagtg tgctcctgtt cctggagtac
    22081 ctcccatgga acctgcacga ctggctcggt gagcggatgg ccgccggcga tgaggccgcc
    22141 gagcgggcct gcgccatggt ggacgacgag ctgagagcgg gcatcgcgtt catgaacgcc
    22201 aacggggtgc tgcacttcga cgcgcacttc gagaacatcc tcaccgacgg ccggcggctg
    22261 ttcttctccg acttcgggct ggcgttctcg tcccgtttcg acctggcgcg ggcggaggcg
    22321 gagttcttcg agaaacaccg tgtgtacgac cggtgttacg ccgtcacaca tctcgtgaac
    22381 tggctgaccg tggctctgct cggacacgag ccggaggagc gcgcggcgtt cgtgcgggcg
    22441 tgcgcggaag gggcccggcc gacacggatg cccgcttcga tcgccgatgt cgtcgcccgg
    22501 tacgcgccgg tcgcggaggt gatgggggac ttccgccacc agttccggac ggtgagccgg
    22561 acggcgcctt tcccgttcac ggcgatccgg cagagactgg agaagtgcga tcagtgagga
    22621 gccagggagt tccatggatc cggtcgtgcc cacgcccgtc gcggatcagc tgttcgggca
    22681 ggtggagatc gaactcgatc acgagggcgg cacgttacgt gtgagcgggg gcggactgcc
    22741 gacggtcagg atccggcgca gcccggacac ggaggtggcg acgcgtgtgc cgatcggcac
    22801 gcgcgacccc gcacggctca ccttgctcgt cgacggtgtc gaggagacgc ctcgtcccgc
    22861 gaagggctta ctgtcccgga ggtcgtaccg ggtcgaggtc gtctcggcga cgcgggactg
    22921 ccggtatgtg ctggtgccga actcctccga caccagccgc ctgcggcggg acaagcggcg
    22981 gctcggcgtc ttcacctcga ccggcgacgg gaaggtctcg gccgtgtggg agaacggtga
    23041 gcgccgttca acggccgcac cggagccgta cgacgcggcc gtgggctacg ccctcgccgc
    23101 cgcctacggg accggagcgg aaccgatgtg gcacgaggcg ttggacgcgg tgacggaact
    23161 ctggccctga ggctccaccg cacggtggct gactgccact cctcttccgg caggccgagg
    23221 aggcgttccg tctcctgggg ggcggcaggg gcccccggag cggcgtcggg ctgcaaggtc
    23281 gcccacctgc cgggaccggg cgatgcggcg gatcgccggc tctgcccgag cgaggcgaag
    23341 accgacatcg acattcttga caacggctcc ggcaagacct gtcgccgggc cgatcagcaa
    23401 aagaacgcct tgtggtgcta ctcgatggac gtcgcgtcct tcggcacgat ggactttcct
    23461 catggcaagt ggtactgcct gtacgggtga tgagtgacag ccttccccac ttccgctatc
    23521 acccggaccc cgtggccacc gggtccatcc gcgcgtccgc cgaccggtgc gtgtgttgcg
    23581 ggcgcagcag gggatggatc tacacggcca ccttctacac cgcctgcgac gtcgacgggc
    23641 ccttctgccc gtggtgcatc gcggacggca gcgcggccga acgcttcgag ggtgacttca
    23701 ccgactgcta cgggctcgac gacgtcagca tggacgtcgt ccacgaggtc acccgacgca
    23761 cccccggctt ccacggctgg cagcagccgc actggcttac ccactgcggg gacgcggcgg
    23821 ccttggtcgg cgaggtcggc cacgcggaac tggcgcgaca cccggaagcc cttgcgcagc
    23881 tcggcgactt cgcacctcat ctgggcggtg atgccgctgc ggtgctgttc cgctgcacgg
    23941 tgtgcggcag ccatctcgcc tacgcggacg cctcctgagg acgtccacag ctacccgaag
    24001 cagagttccg cgtccttcgc cacgcagatg cgcaggactg tgatcagccg gccgacgtcc
    24061 tcgacgtgtt gccggacgtc gggatcgctg tcgtcggcca cgtgatcgtc gtggacttcc
    24121 tcgagccgcg gcagtatcgc cgcgcattgg gcaggtgtga gttccccatg gtcgtccggg
    24181 tggtcgagca gtggcgccaa cgtcgtgtgc acactggacc acgggcgttc tccaccgaag
    24241 ccgtccatgt cgtcgagcgt gaacccctcg atccgggcca gccatcctcg gaacgaggcg
    24301 aaaccggagt aggtccattc gacgtccggg ctcgtcacgt cgccgtcgcc cgggaagagc
    24361 atcagcccca tgtcacaccc ctctgtcggc ttccaacccg tgctggaccc gcggcacacg
    24421 cgggagcacc gaaggcatac ttcatcccca tgacgatcgc atacgagtgg cgcggtgacg
    24481 tcgacaacgg tgtcctcaac gccttgcacg ccgaagggtt cggcggggc
//
