LOCUS       NZ_CP104794            11863 bp    DNA     linear   CON 09-JUL-2024
DEFINITION  Streptomyces sp. FZ201 chromosome, complete genome.
ACCESSION   NZ_CP104794
VERSION     NZ_CP104794.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. FZ201
  ORGANISM  Streptomyces sp. FZ201
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8604396)
  AUTHORS   Zhang,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2022) College of Life Science and Technology,
            Jinan University, Guangzhou, Guangzhou, Guangdong 510632, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAY-2021
            Assembly Method                   :: unicycler v. 3.14.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.1x
            Sequencing Technology             :: Illumina NovaSeq6000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025402955.1-RS_2024_07_09
            Annotation Date                   :: 07/09/2024 06:54:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,471
            Genes (coding)                    :: 7,336
            CDSs (with protein)               :: 7,336
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 135
            CDSs (without protein)            :: 135
            Pseudo Genes (ambiguous residues) :: 0 of 135
            Pseudo Genes (frameshifted)       :: 55 of 135
            Pseudo Genes (incomplete)         :: 92 of 135
            Pseudo Genes (internal stop)      :: 7 of 135
            Pseudo Genes (multiple problems)  :: 18 of 135
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:45:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8041047
            Orig. end                         :: 8052910
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP104794.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zhang Fei, College of Life
            Science and Technology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11863
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="31"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11863
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11863
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6863](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6863
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(471..1100)
                     /locus_tag="N6J21_RS35360"
     CDS             complement(471..1100)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="N6J21_RS35360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_261720280.1"
                     /transl_table=11
                     /translation="MPGVGVEAERARLRRELHDGLGPSLSGIGLCAQALAELLDGSGTD
                     TERALLDRIRAEVALATAEVRRLLDGLAPAALASHGLVEALRRHARSVSPATAVEIVES
                     SLPNLPPPLQATAYRIVTEAVTNVVRHAGARHARVTLAGRRRSLLIGVADDGRGTGRVS
                     PGVGLTSMRQRAEAAGGRFSLRSTPGGGTEVRVRLPLERPRAAQPV"
     gene            complement(1103..1348)
                     /locus_tag="N6J21_RS35365"
     CDS             complement(1103..1348)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N6J21_RS35365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_093722908.1"
                     /transl_table=11
                     /translation="MTDILTAARAEALFSSDLVTGSAPTRAEIASAIRRAIRRHGGSLG
                     CAGTLARAYGEQPETAVPRMRWALSQVRSAYPRRRV"
     gene            1732..4623
                     /locus_tag="N6J21_RS35370"
     CDS             1732..4623
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="N6J21_RS35370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_261720698.1"
                     /transl_table=11
                     /translation="MTGRERFDGLRFQVLGPLRAWRDGAELDLGPSQRRVVLAVLLLRA
                     GRPMNRERLVEAVWGDALPARAANLVQRHVSALRRVLEPERAPRSPSGLLAWTEAGYLL
                     TLGAHQSDLRRCEELIGRAHTARARGDLSATAECLRAALRLWQGPLCEGLASPLLDAER
                     DRLAERRLSVLEERIEVDLALGDDFDLAGEVRQLTEAHPLREGLHGLLMLALHRSGRQA
                     EALAAYHRARRLLRDELGIEPGQRLRRLHTRILAADPDLDTGEAQPTRPRADAARTEPP
                     ASVVPAQLPHPVAGFVGREEALALLDALLPTDPDGPKQAMAVITAIGGTAGVGKTTLAV
                     HWAHRVRHRFADGQLYVNLRGFDPGGPAVHPAEAVRGFLDALGVPPRRIPVNPDGQIGL
                     YRSLLANRRMLVVLDNAQDTDQVRPLLPGSPHCCTVITSRNLLTGLVITDGARPVTLGL
                     MSRAEATDVLGHRIGGHRLTGDPDALEDIIASCARLPLALAIVGAHAATQPQLPLASVA
                     KELRAAGSALDLLDGGDAATDVRKVFSWSYRRLTEPAARLFRLLGLHPGPDIGTAAVTG
                     IAGLPAEQVRSQLAELTASHLLFSPAADRYAGHDLLSAYAAELARTHDTSADRTAAVRR
                     MLDHYLHSAYRASLHLSPHRDDPIALAPPRAPVTGERFAGHDEALSWFLREHAVLLSVQ
                     RLAVDHGLDGHAWQLAWALQPYFDRAGHWHDSAAAHERALAAARRAGSTHGQAVVHGCL
                     AYAYMRLSRYEEVATHMRQALHLYETLGDVLGQAHTHRTLCWLNDEKGQYEQGLDHARR
                     ALELFSAAGHRTGRARALNALGWFCSRLGRHQEALTHCEQALRLLEEADDRFDQGDTWD
                     SLGHIHRHLHHYEQAAECFERALALYRETGDRYNEADTLYSLGDLHLTAGDRGAATAAW
                     RRSADVLDELGHRRAAQVRARLTTETESKSPEN"
     misc_feature    1918..1920
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4297..4299
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4681..4696)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.44"
                     /tool="antismash"
     gene            4692..4985
                     /locus_tag="N6J21_RS35375"
     CDS             4692..4985
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N6J21_RS35375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_261720281.1"
                     /transl_table=11
                     /translation="MEKEEVDWRDIVGLAEKLERVDIFTDAEIKALRLVFDVAGNILVP
                     DTPVAQTLGTLLPGSDSERTRRAFKVYELYSAEPVTAEPPEFDPPDSGPGRC"
     gene            5001..6863
                     /locus_tag="N6J21_RS35380"
     CDS             5001..6863
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="N6J21_RS35380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_261720282.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.3e-188, bitscore:
                     626.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTAHDAWPVVLVCMPFMDDRRPSLQAGLLAALARAEGFPARTLH
                     ANLDFAAGIGVETYRTLAGRPGQLAGDWLFSLEAFGPAAPDPRGDYLDLCADDLAREHG
                     IPADRLRERLLRIRQREVPAYLDALADAPFWQDTQVVGFTSTFQQNNASIALARRLRQR
                     HPHLFTVFGGANFDAPMGPELVRTVDCVDAAVIGEADTAFPHLLRTLATGGDLGSVPAL
                     ARRVDGKVVTGPPAPPTRNLDDLPMPDYDEYFRRAENLGLLPRTASRAVHLPVETARGC
                     WWGAKHHCTFCGLNAQTMNFRSKSGPRVLDELAHLARRYRSFRFEAVDNILDMRYFRTL
                     FPALVESEASYDLFHEVKANLARAQIELLAAAGVTRIQPGIESLSTRVLSLMRKGVTVA
                     QNVNLLRWARHYGIEVDWNLLWGFPGERPEDCSAQAALMPHLWHLTPPGDAGRLAMQRF
                     SPLFTDREGILRDLRPAPPYRYVYPADTDLDRVAYFFSYRLDGALPDDAYAGLRTAVTD
                     WQEAWSDSGAPPVLEYRRAPHYVQIHDSRRSDGAGTHVFEGTAADLYLACCDRPVTADA
                     VRARLGPREPADDVRRVLDTFTEAGLVLRDGPRYLALAVPAARH"
     gene            6882..8315
                     /locus_tag="N6J21_RS35385"
     CDS             6882..8315
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="N6J21_RS35385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_093722905.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.8e-19, bitscore:
                     68.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYRIDGRLPSLVYAQASPRSQGGESVFDAGEIRADNVEDYLATD
                     VVTQRAERELAAAGFTVLDSSPAGINIAGPPELYDRYFETTLITEEREVIQPGAVELRR
                     TRTFLDTARADRPGLISTRGLPAAEFLEGVALEQPATTLHGTAAPVPKPDYWHLTTDMV
                     AEYLGARAAHDQGITGAGVRLVMVDTGWEPHPYFRERGLRGTVVLGPGTADPEVDEDGH
                     GTCESANAFAVAPGIDFTMVKAKDTNLLAAFNTALRQQPDIISMSLEYHVKTPEEAIEP
                     MLAVAVSLAVRSGVVVVCAAGNGHYAFPAQHPGVIAVGGVHRDEHGVHRASDYASAFTS
                     TLFLGRVVPDVCGLVGMRPGATYILLPAPRGSSIDQHRAAKPYPDGDGTTPGDGWVVLS
                     GTSAAAPQVAGVCALLRQADRELTPRRIRTLLQDSALDIDQGAGNPDTGGLTALAPDGT
                     HRFKLVRADRALSLLGRRP"
     gene            complement(8339..9088)
                     /locus_tag="N6J21_RS35390"
     CDS             complement(8339..9088)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N6J21_RS35390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_093722904.1"
                     /transl_table=11
                     /translation="MPTPTSQSTVAVWTTGVLALIPPVLAAAAGLLLHSQDAERVAQLA
                     AVLTALITAGVPVLHRSTGADCRRAADDCGHVTHLTGPLPRIVPSATTVALSLALGVAA
                     FWLLYLLSTWLGLGSLGYWSGEYPSDPSEVYRKVALRGLPVLVPGVFAIGVAMAHRLHG
                     LARPVLLLTSVLFTVSVLVSNAVLVRHRRSEPLPEDVYVPLLLGALAWLVCLAARAYAA
                     RTQRLFDLMQAVRLEYRRTAESADSRA"
     gene            9226..9942
                     /locus_tag="N6J21_RS35395"
     CDS             9226..9942
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486414.1"
                     /locus_tag="N6J21_RS35395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_261720283.1"
                     /transl_table=11
                     /translation="MSEGIGPVRVVIADDHPMFRYGLVAALSSSGDVWVVGEAADGDGL
                     LAAVDRTAPDVVVTDLAMPGLDGTAATRALAARRPAPAVLVLTMHEDDEALFGALRAGA
                     RGYLLKDADSTEIARAVLAVAAGNAVYGRAVARRIADFFTGAHRDYAAQVFPELTERER
                     EVLDLIALGLGNHQIAARLVLAEKTVRNHVSAILYKLQVSDRAAAVARARDAGLGGPPK
                     RPDGLRPPGRPRSPGS"
     gene            complement(9905..11107)
                     /locus_tag="N6J21_RS35400"
     CDS             complement(9905..11107)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129019.1"
                     /locus_tag="N6J21_RS35400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_261720284.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 8.5e-17, bitscore:
                     60.7, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFSLGIVGAGQFSGGFAKLFRAHPGVSDVYVTDLLPERAEQLAV
                     AEGLSGTFPSYEAMLESPSVDAVAVFTQRWTHGPLVLQGLSAGKHVYSAVPMAITTEEI
                     AAIIEAVRATGLTYMMGETSQYNPATVHARNQIAKGAFGRLFYAEGDYVHDMDLGFYEA
                     YQYSGGENWKATASYPPLLYPTHAVGGVLGAWQTHAVSVSAIGVVDERGDGVFDKDVSR
                     FGNDVSNATALFEVAGGGSFRTNEFRRVGYPSHIRESRFRFFGTEASMEQLATVALWQD
                     KTGVEDISELLEPKPTLAPDDPSLQHIAPDLRAAFTSGSAPVHDRARLPRVFDNLPNGH
                     EGSHHFLVDDFVTAVNTRTLPSVNAWVAARYTLPGIIAHESARQGGARLTIPDFGDAPE
                     A"
     misc_feature    11180..11195
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
ORIGIN
        1 taggtcagct ggaccagcag cgcgtacgtg cggccggcct ggaggttcga caggacgatg
       61 tcgcgctggt agtcgccccc gttcatcggt acggaggcgg gcgccgcggg ctcggggaag
      121 tcgtccgagc cgcccatctc gtcgaccttg acctggacgt accaggtgcc ggagagcagc
      181 ggaacgagga agccggtgag gtgccagtcg atccgtacgg tgaccggggt gcccttgttg
      241 acgacatcgg cggggttgcc gtccgggtcc aggacgatgg cgccgatacg gccgtcgagg
      301 gccgtggtgg ggacggggag cgactggaag gtgccagagg ccatgggatg actccttgtc
      361 ggaactgacc ggtgatggac gcctcaacgg tccggcgccc ggaaccttcg cagcagaggc
      421 aggtgtcccg acccgggcgg gccgttgtcc ggggccgacc gggcgccgga tcacaccggt
      481 tgggccgcgc ggggccgttc cagcggcagc cggacccgta cctcggtgcc ccctccgggt
      541 gtactgcgca gggagaaccg cccgcccgcc gcctcggcgc gctgccgcat cgaggtcagg
      601 cccacacccg ggctgacccg cccggtccca cggccgtcgt cggcgacacc gatcagcagg
      661 gaccgccgcc gtcccgccag cgtgacccgg gcgtgccggg cacccgcgtg ccgtacgaca
      721 ttggtcaccg cctccgtcac gatccggtac gccgtcgcct gcaggggcgg gggcaggttc
      781 ggcagtgacg actcgacgat ctccacggcc gtcgcggggg agaccgaccg ggcgtgccgg
      841 cgcaatgcct cgaccagccc gtgcgaggcg agcgcggcgg gcgcgagccc gtcgaggagc
      901 cggcggacct ccgcggtcgc cagggccacc tcggcgcgga tacggtccag cagcgcccgc
      961 tcggtgtccg tgccgctgcc gtccagcagc tccgccaggg cctgcgcgca caggccgatc
     1021 ccggagagcg aagggcccag cccgtcgtgg agttcgcggc ggaggcgggc gcgctcggcc
     1081 tccaccccaa ccccgggcat gctcataccc gtcggcgcgg gtaggcggac cgcacctggc
     1141 tcagcgccca gcgcatccgc ggtaccgcgg tctcgggctg ctcgccgtag gcgcgggcca
     1201 gggtgcccgc gcagccaagg ctgccgccgt gccggcggat cgcccgccgg atcgccgagg
     1261 cgatctcggc gcgggtcggc gccgagccgg tcaccaggtc gctgctgaac agcgcctcgg
     1321 cgcgggccgc ggtcaggatg tccgtcatgg gtactcccgg tcctcggggg cggtgcctgt
     1381 gctcgccccg gttcgggcac cagcgtgcga tcccgggttg cagtcaccac tgcaccggcc
     1441 gctgcaccac tgggtcgtgt ccgcgaagtc ccgcccgccg ccccatgccg ggcacgccct
     1501 ggccgcaccg gcgtgccgca ggtgcgtggg cgtccgtccg gagcacctcc tggcccttcg
     1561 aaccggggga gacccccgga gcacgaggcc ccacggggca cccccatgcc gctgtccggc
     1621 ccgccctccg ggctgacgac gcgacttcgc acgtacacga cctggcgggc ggtgccggta
     1681 ccggttcggc gctagcttgg acggcagggg acgagggtgg gggcccgtgt gatgactggg
     1741 cgagagcggt tcgacggtct gcggttccag gtgctcggac cgctgcgcgc ctggcgggac
     1801 ggggcggagc tggatctcgg gccctcgcag cggcgcgtgg tgctcgccgt gctgctcctg
     1861 cgcgccggac ggcccatgaa ccgggagcgg ctcgtcgaag ccgtctgggg cgacgcctta
     1921 ccggcgcggg ccgcgaacct ggtgcagcgg catgtctccg cgctgcgccg ggtgctggaa
     1981 cccgagcgcg ccccgcgcag cccgtcgggg ctgctcgcct ggaccgaggc cgggtacctg
     2041 ctgaccctgg gggcgcacca gtcggacctg cgcaggtgcg aggagctgat cgggcgggcg
     2101 cataccgcac gggcccgggg cgacctctcc gcgaccgcgg agtgcctgcg cgccgccctg
     2161 cgcctgtggc agggcccgct ctgcgagggg ctggcgagcc cgctgctcga cgcggagcgc
     2221 gaccggctgg ccgaacggcg gctgagcgtg ctggaggagc gcatcgaggt cgacctggcg
     2281 ctcggcgacg atttcgacct cgccggcgag gtacggcagc tcaccgaggc gcacccgctg
     2341 cgggaagggc tgcacgggct gctcatgctc gccctgcacc gctccggacg gcaggccgag
     2401 gccctggccg cctatcaccg ggcccgccgg ctgctgcggg acgaactcgg catcgaaccg
     2461 ggacaacgac tgcggcgcct gcacacgagg atcctggccg ccgacccgga cctcgacacc
     2521 ggggaagcac aacccacccg tccgcgtgcg gacgcggctc gcacggaacc gcccgcctcg
     2581 gtcgtacccg cccaactccc ccaccccgtc gcgggtttcg tcggccgcga ggaggcactc
     2641 gcgctgctcg acgccctgct gccgacggac ccggacggcc cgaaacaggc catggccgtg
     2701 atcaccgcca tcggcggcac cgcgggcgtc ggcaagacga ccctcgccgt gcactgggcc
     2761 caccgcgtcc gccaccgctt cgccgacggc cagctctacg tcaacctccg gggcttcgac
     2821 cccggcggcc ccgccgtcca ccccgccgag gcggtccgcg gcttcctgga cgccctcggc
     2881 gtcccgcccc gccgtatccc ggtcaacccg gacggccaga tcgggctcta ccgcagcctg
     2941 ctggccaacc ggcgcatgct cgtcgtcctc gacaacgccc aggacaccga ccaggtacgc
     3001 ccgctgctgc ccggctcacc gcactgctgc accgtcatca ccagccgcaa cctgctcacc
     3061 ggcctggtga tcaccgacgg cgcccggccc gtcaccctcg gcctgatgtc ccgcgccgag
     3121 gccacggacg tcctcggcca ccgcatcggc ggccaccggc tcaccggcga cccggacgcg
     3181 ctggaggaca tcatcgcctc ctgcgcgcgg ctcccgctcg ccctggccat cgtcggcgcg
     3241 cacgccgcca cccagccgca actgcccctc gcctcggtcg cgaaggaact gcgggccgcg
     3301 ggcagcgccc tggacctgct cgacggcggc gacgcggcca ccgacgtgcg caaggtgttc
     3361 tcctggtcct accgtcgcct caccgaaccc gccgcccggc tgttccgcct gctcggcctg
     3421 cacccgggcc ccgacatcgg cacggccgcc gtcaccggaa tcgccggact gcccgccgag
     3481 caggtccgtt cacagctcgc cgaattgacg gcaagtcacc tgctgttctc gccggccgcc
     3541 gaccgatacg ccggccacga cctgctgagc gcctacgccg ccgaactcgc ccgtacgcac
     3601 gacacttccg ccgaccgcac ggccgcggtg cgccgcatgc tcgaccacta cctgcacagc
     3661 gcctaccgcg ccagcctcca cctgagcccg caccgggacg accccatcgc cctcgccccg
     3721 ccccgggcac ccgtcaccgg ggagcggttc gcgggacacg acgaggccct ctcctggttc
     3781 ctgcgcgaac acgccgtact gctgtcggtg cagcggctgg ccgtggacca cggactcgac
     3841 ggccacgcct ggcagttggc ctgggcgctc cagccgtact tcgaccgcgc cgggcactgg
     3901 cacgactccg ccgccgcgca cgaacgggcg ctggccgccg cccggcgcgc cgggagcacc
     3961 cacggacagg ccgtggtgca cggctgcctg gcgtatgcgt acatgaggct cagccgctat
     4021 gaggaggtcg ccacccacat gcggcaggcc ctccacctgt acgagacgct cggcgacgtc
     4081 ctcggtcagg cccacaccca tcggacgctg tgctggctca atgacgagaa aggacagtac
     4141 gaacaggggc ttgaccacgc ccgccgggca ctggagttgt tcagcgcggc cggccaccgc
     4201 acggggcggg cgcgggcgct caacgcactc ggctggttct gctcccggct gggccgccac
     4261 caggaggcac tcacccactg cgaacaggca ctccggttac tggaggaggc cgacgaccgc
     4321 ttcgaccagg gcgacacctg ggacagcctc ggtcacatcc accgacatct gcaccactac
     4381 gagcaggccg ccgagtgctt cgagcgggcg ctcgccctct accgggagac cggcgaccgc
     4441 tacaacgagg ccgacaccct ctactccctg ggcgacctgc acctgaccgc gggggaccgc
     4501 ggtgcggcga ccgcggcctg gcggcggtcg gccgacgtgc tggacgaact cggacaccgc
     4561 cgagccgccc aggtgcgcgc ccgcctcacc accgaaacgg aatccaagtc gccggaaaat
     4621 tgactccctt gacgcaagga tggcgcgtcg tcagactccc cgccattcca tgcacgacag
     4681 ggggaaagat cgtggaaaag gaagaagtcg actggcggga catcgtgggc ctcgccgaga
     4741 aactggaacg ggtggatata ttcaccgacg ccgagatcaa ggcattgcgt ctggtgttcg
     4801 acgtagcggg aaatatcctc gtcccggaca caccggtggc gcagacgctc ggcacgctcc
     4861 tgcccggctc cgattccgag cggacccggc gcgcgttcaa ggtgtacgag ctctactcgg
     4921 cggaaccggt gacggccgaa ccaccggaat tcgacccacc cgactccgga cccgggcggt
     4981 gctgacccgg ggcccgcgcg atgcccacgg cccacgacgc ctggccggtc gtcctggtgt
     5041 gcatgccctt catggacgac cgccgcccct ccctccaagc cggtctcctc gccgcgctcg
     5101 cccgcgccga gggcttcccg gcccgtaccc tccacgccaa cctggacttc gcggccggga
     5161 tcggcgtgga gacgtaccgg accctcgccg gccggcccgg ccagctggcg ggggactggc
     5221 tgttctccct ggaggcgttc gggcccgcgg cacccgatcc gcggggcgac tacctggacc
     5281 tctgcgccga cgacctggca cgggaacacg gcatccccgc cgaccgcctg cgcgagcgcc
     5341 ttctgcgcat ccggcagcgg gaggtccccg cctacctcga cgcgctcgcc gacgcgccgt
     5401 tctggcagga cacccaggtc gtcggcttca cctcgacgtt ccagcagaac aacgcctcca
     5461 tcgcgctcgc ccggcggctg cggcagcgcc atccgcacct gttcacggtc ttcggcggcg
     5521 ccaacttcga cgcccccatg ggcccggaac tggtccgcac cgtcgactgc gtggacgccg
     5581 ccgtcatcgg ggaggccgac accgccttcc cccacctgct gaggaccctc gccaccggcg
     5641 gcgacctcgg ctccgtaccc gcgctggccc gccgcgtgga cggcaaggtc gtcacgggac
     5701 caccggcacc accgacacgg aacctcgacg acctgccgat gccggactac gacgagtact
     5761 tccggcgggc cgagaacctc gggctgctgc cccgcacggc gtcccgcgcc gtccacctcc
     5821 ccgtggaaac cgcgcgcggc tgctggtggg gcgcgaaaca ccactgcacc ttctgcggcc
     5881 tcaacgccca gaccatgaac ttccgttcca agtccggccc gcgcgttctc gacgaactgg
     5941 cccacctggc ccgcagatac cgcagtttcc gtttcgaggc ggtcgacaac atcctcgaca
     6001 tgcgctactt ccggactctt ttcccggccc tcgtggaaag cgaggcgagt tacgaccttt
     6061 tccacgaggt gaaggcgaat ctcgcccggg cccagatcga actcctcgcc gccgcgggcg
     6121 tgacccggat ccagcccgga atcgaatcac tcagcacccg cgtactgagt ctgatgcgca
     6181 agggcgtgac agtcgcccag aacgtcaatc tcctacgctg ggcgcggcat tacggaatcg
     6241 aggtggactg gaacctgctg tggggatttc ccggtgagcg gcccgaggac tgctccgcac
     6301 aggccgccct gatgccccac ctgtggcatc tgacaccacc gggggacgcc ggacgcctcg
     6361 ccatgcagcg cttcagcccg ctcttcaccg accgggaggg catcctgcgc gacctgcgcc
     6421 ccgcaccgcc ctaccgctac gtctatcccg ccgacaccga tctcgaccgt gtcgcctact
     6481 tcttcagtta ccggctcgac ggcgcgctcc ccgacgacgc ctacgcaggc ctgcgcacgg
     6541 cggtcaccga ctggcaggag gcctggagcg acagcggggc accgcccgta ctggagtacc
     6601 ggcgggcacc ccactacgtg cagatccacg acagcagacg aagcgacggc gcgggcaccc
     6661 acgtcttcga gggaacagcg gccgatctgt acctcgcctg ctgcgaccgg ccggtgacgg
     6721 cggacgccgt gcgcgcacgg ctcggaccgc gcgaaccggc ggacgacgtg cggcgcgtcc
     6781 tggacacctt cacggaggcc gggctcgtcc tgcgcgacgg accgcgctac ctggcactgg
     6841 ccgtaccggc cgcacgccac tgacctttgg gggaaccaca catggcctac aggatcgacg
     6901 gacggctgcc cagcctggtg tacgcgcagg cgtcaccgcg ctcgcagggc ggcgagtccg
     6961 tcttcgacgc cggtgagatc agggcggaca acgtggagga ctacctcgcc acggacgtgg
     7021 tcacgcagcg cgcggaacgg gaactggccg ccgccggatt caccgtcctc gacagctcac
     7081 cggccggcat caacatcgcc ggtccgcccg agctgtacga ccgctacttc gagaccaccc
     7141 tgatcacgga ggaacgcgag gtcatccagc ccggcgcggt ggaactgcgc aggacccgca
     7201 ccttcctcga caccgcccgc gccgaccggc ccggactgat ctccacccgg gggctgcccg
     7261 ccgccgagtt cctggagggc gtggccctgg aacagccggc caccaccctg cacggcaccg
     7321 ccgcccccgt ccccaagccc gactactggc acctgactac cgacatggtc gccgagtacc
     7381 tgggcgcccg cgccgcccac gaccagggca tcaccggcgc cggagtccgg ctcgtcatgg
     7441 tggacaccgg ctgggagccc catccgtact tccgggaacg cggcctgcgc ggcaccgtcg
     7501 tcctcgggcc gggcaccgcc gaccccgagg tggacgagga cgggcacggc acctgtgagt
     7561 ccgccaacgc cttcgcggtc gcgcccggca tcgacttcac catggtcaag gccaaggaca
     7621 ccaatctgct ggcggccttc aacaccgcgc tccggcagca gccggacatc atcagcatga
     7681 gcctggagta ccacgtcaag acacccgagg aggccatcga gcccatgctg gcggtcgccg
     7741 tctccctcgc ggtccgctcc ggggtcgtcg tggtgtgcgc ggcgggcaac ggccactacg
     7801 ccttccccgc gcagcacccc ggcgtcatcg ccgtcggcgg ggtccaccgc gacgagcacg
     7861 gcgtgcaccg ggcctccgac tacgcgagcg ccttcaccag caccctgttc ctcggccggg
     7921 tcgtgcccga cgtgtgcggc ctggtcggga tgcggcccgg cgccacgtac atcctgctgc
     7981 ccgcgccccg cggctccagc atcgaccagc accgggccgc caagccgtac cccgacggcg
     8041 acggaaccac ccccggcgac ggctgggtgg tgctcagcgg cacctcggcg gcggcacccc
     8101 aagtcgccgg agtctgcgcc ctgttgcggc aggccgaccg ggagctgacc ccgcgccgga
     8161 tccgcaccct gctccaggac agcgcgctgg acatcgacca gggcgccggc aacccggaca
     8221 ccggcggcct gaccgccctc gcccccgacg gcacacaccg gttcaagctc gtacgggccg
     8281 accgggcgct gagcctgctc ggccgccggc cgtgagcaga accgggcgcc gaggggtctc
     8341 aggcccggct gtccgccgat tccgcggtgc ggcggtactc cagccgcacc gcctgcatca
     8401 ggtcgaacag ccgctgggtg cgggccgcgt acgcgcgggc ggcgaggcag accagccacg
     8461 ccaacgcgcc cagcagcagc ggcacataca catcctccgg cagcggctcg ctgcgccggt
     8521 ggcggaccag caccgcattg ctgaccagca ccgacacggt gaacagcacg ctcgtcagca
     8581 gcagaacggg ccgcgccaga ccgtgcagcc ggtgcgccat ggccacgcct atggcgaaga
     8641 caccggggac caggaccggc agaccgcgca gcgcgacctt gcggtagacc tccgaggggt
     8701 cactggggta ctcgccgctc cagtagccga ggctgcccag accgagccag gtactcagca
     8761 ggtacagcag ccagaacgcg gcgaccccga gcgccagcga cagcgcgacc gtcgtggcgc
     8821 tcggcacgat cctcggcaac gggcccgtca gatgggtgac atgaccgcag tcgtcggcgg
     8881 cccggcggca gtcggcgccg gtcgagcggt gcagcaccgg cacaccggcc gtgatcagcg
     8941 cggtgagcac ggcggcgagc tgggcgaccc gctcggcgtc ctgcgagtgc agcagcagcc
     9001 ccgccgcggc ggcgaggacg ggcgggatca gagccagcac accggtcgtc cagacggcga
     9061 cagtgctctg ggaggtgggc gtcggcatgg cgctcccacg ggtgggttcg ggtgcgggac
     9121 gcagcacatg gtcgccgccc gccgccgcac cggcctgagg cacaggtcct cacccggccg
     9181 ggcgggccgc cctcgtacgg cgggaccggg acaccgggag gatccatgag cgaggggatc
     9241 ggccccgtcc gcgtggtcat cgccgacgac caccccatgt tccgctacgg ccttgttgcc
     9301 gccctgagtt cgagcggtga cgtctgggtc gtcggcgagg ccgccgacgg cgacggcctg
     9361 ctcgccgccg tcgaccgcac ggcacccgat gtcgtggtca ccgacctcgc catgcccggc
     9421 ctcgacggca ccgccgccac ccgcgccctc gccgcccgcc gccccgcacc ggccgtgctg
     9481 gtcctgacga tgcacgagga cgacgaggcc ctgttcggtg ccctgcgcgc cggggccagg
     9541 ggctacctcc tcaaggacgc cgacagcacc gagatcgccc gcgccgtcct cgccgtcgcc
     9601 gcgggcaacg ccgtgtacgg ccgcgccgtc gcccgccgga tcgccgactt cttcaccggc
     9661 gcccaccgcg actacgcggc gcaggtcttc cccgaactga ccgagcggga aagggaagtg
     9721 ctcgacctga tcgccctcgg tctgggcaac caccagatcg cggcgcggct ggtgctggcc
     9781 gagaagaccg tccgcaacca tgtctcggcg atcctgtaca agctccaggt ctccgaccgg
     9841 gccgcggcgg tggcccgcgc ccgcgacgcg ggcctgggcg ggccaccgaa gcggccggac
     9901 ggactcaggc ctccggggcg tccccgaagt ccgggatcgt gaggcgggcc ccgccctgcc
     9961 gggccgactc gtgggcgatg atgcccggca gggtgtagcg ggcggcgacc caggcgttca
    10021 cggacggcag ggtgcgggtg ttgaccgcgg tcacgaagtc gtccaccagg aagtgatggc
    10081 tgccctcatg gccgttgggg aggttgtcga acacccgcgg cagacgggcg cggtcgtgca
    10141 ccggggccga acccgaggtg aacgccgcgc gcaggtccgg cgcgatgtgc tgcagcgagg
    10201 ggtcgtccgg cgccaacgtg ggcttcggct ccagcagttc gctgatgtcc tccaccccgg
    10261 tcttgtcctg ccacagggcg accgtggcga gttgctccat gctcgcctcc gtgccgaaga
    10321 aacggaaacg ggactcgcgg atgtgcgagg ggtagccgac ccgccggaac tcgttggtgc
    10381 ggaacgagcc gccgcccgcg acctcgaaca gcgcggtggc gttggagacg tcgttgccga
    10441 accggctgac atccttgtcg aagacgccgt cgccgcgctc gtcgacgacc ccgatcgcgg
    10501 agacgctcac cgcgtgggtc tgccaggcgc cgagcacccc gcccaccgcg tgggtcgggt
    10561 acagcagcgg cggataggag gcggtggcct tccagttctc gccgccgctg tactggtacg
    10621 cctcgtagaa ccccaggtcc atgtcgtgga cgtagtcgcc ctcggcgtag aagagccgtc
    10681 cgaaggcgcc cttggcgatc tggttgcggg cgtgcacggt cgccgggttg tactggctgg
    10741 tctcgcccat catgtaggtc agtccggtcg ccctgaccgc ctcgatgatc gcggcgatct
    10801 cttccgtggt gatcgccatc gggaccgcgg agtagacgtg ctttccggcg ctcaggccct
    10861 ggagcaccag cgggccgtgg gtccagcgct gggtgaagac ggcgaccgcg tcgaccgatg
    10921 gtgactccag catcgcctcg tacgagggga aggtgcccga cagcccttcg gcgacggcca
    10981 gttgttcggc gcgctccggc aggaggtcgg tgacgtagac gtcgctgaca ccggggtggg
    11041 cccggaacag cttggcgaag ccgccggaga actggccggc gccgacgatg ccgagggaga
    11101 acgtcatgga gtgagtgcct ttcactggcc gaggatgaga ttgatctggt cgttggtcct
    11161 ggacaggtcg ctcaccgggg cgccgttggc gtacacgtcc tgcatcgcgg gccgcatcag
    11221 ggcgtacacg tccgccgcgt agtcggtgac cgggaaggag aaggtcaggg agtcccggcg
    11281 gccggtgacc ggttcggtga aggcggacac gtcgatgccc ttcttctcgt acgcggccac
    11341 cgccgcccgc gtgccctcgg gggtcgccgg gaagacgatg ccgtagcggc ccaccgtgcg
    11401 ctggcactcg tcggaggcca ggtacttgac ccatttgcgg gcgccggact tgttgtcggc
    11461 gttcttggtg atggagtcgg cgaggccgtt catcatcgtg gcgcgcttgc cggtggggcc
    11521 ggtgggcgtg agggcggtgc cgacgtcgag gcccttggtg ccgtagtacg tggagatcat
    11581 ccacgcgccg tcgaaggagg ccgcggcctt gccggaggcg agctgggcgc tggccgggtt
    11641 ggcgccgtcg gtgtagtcgg tgaagggcgc gagatagccc ttctcggcca ggccgaagta
    11701 ccagtcgatc acctgctgga aggtacggtc gccgtactgg tactcggtgc cccagcgggc
    11761 cttgtcggtg tagtgccagc ccgccgacgc ggtgaacggg ctccaggtgg tctgcccgtc
    11821 gccgtccccg gcgccaccgg tggccaggcc gtacaccttg acg
//
